CDC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.57603146
2chromosome organization involved in meiosis (GO:0070192)7.35359844
3synaptonemal complex assembly (GO:0007130)7.14395687
4synaptonemal complex organization (GO:0070193)6.15492984
5male meiosis I (GO:0007141)6.13816060
6regulation of meiosis I (GO:0060631)5.91007247
7meiotic chromosome segregation (GO:0045132)5.68562449
8sister chromatid cohesion (GO:0007062)5.61587961
9piRNA metabolic process (GO:0034587)5.52536211
10meiosis I (GO:0007127)5.23546740
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21400150
12histone H3-K9 demethylation (GO:0033169)5.16542354
13regulation of histone H3-K9 methylation (GO:0051570)5.07620073
14male meiosis (GO:0007140)5.06449732
15DNA unwinding involved in DNA replication (GO:0006268)5.05324976
16regulation of chromatin binding (GO:0035561)5.00775987
17meiotic nuclear division (GO:0007126)4.95682725
18histone H3-K36 demethylation (GO:0070544)4.91048216
19DNA synthesis involved in DNA repair (GO:0000731)4.85794972
20embryonic body morphogenesis (GO:0010172)4.75785195
21DNA methylation involved in gamete generation (GO:0043046)4.61069736
22body morphogenesis (GO:0010171)4.53946345
23meiotic cell cycle process (GO:1903046)4.19775527
24regulation of transcription from RNA polymerase I promoter (GO:0006356)4.09145283
25DNA strand elongation involved in DNA replication (GO:0006271)3.96158674
26regulation of RNA export from nucleus (GO:0046831)3.95023566
27formation of translation preinitiation complex (GO:0001731)3.82032147
28DNA replication initiation (GO:0006270)3.77907425
29DNA strand elongation (GO:0022616)3.73604536
30protein localization to kinetochore (GO:0034501)3.72719044
31interkinetic nuclear migration (GO:0022027)3.62573978
32DNA replication-dependent nucleosome assembly (GO:0006335)3.60399804
33DNA replication-dependent nucleosome organization (GO:0034723)3.60399804
34mitotic nuclear envelope disassembly (GO:0007077)3.50669978
35paraxial mesoderm development (GO:0048339)3.49289244
36mitotic metaphase plate congression (GO:0007080)3.44862796
37nuclear pore organization (GO:0006999)3.44482349
38regulation of DNA endoreduplication (GO:0032875)3.43640666
39Golgi transport vesicle coating (GO:0048200)3.41894494
40COPI coating of Golgi vesicle (GO:0048205)3.41894494
41peptidyl-arginine omega-N-methylation (GO:0035247)3.41674028
42reciprocal DNA recombination (GO:0035825)3.37758460
43reciprocal meiotic recombination (GO:0007131)3.37758460
44positive regulation of response to oxidative stress (GO:1902884)3.36307087
45positive regulation of cellular response to oxidative stress (GO:1900409)3.36307087
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36288598
47nucleobase biosynthetic process (GO:0046112)3.36111459
48nuclear envelope disassembly (GO:0051081)3.34307310
49membrane disassembly (GO:0030397)3.34307310
50DNA damage induced protein phosphorylation (GO:0006975)3.33268218
51folic acid-containing compound biosynthetic process (GO:0009396)3.31912890
52telomere maintenance via semi-conservative replication (GO:0032201)3.28097937
53purine nucleobase biosynthetic process (GO:0009113)3.22423057
54positive regulation of SMAD protein import into nucleus (GO:0060391)3.22327927
55IMP biosynthetic process (GO:0006188)3.20317029
56metaphase plate congression (GO:0051310)3.16749080
57regulation of spindle organization (GO:0090224)3.15335485
58nuclear pore complex assembly (GO:0051292)3.10471024
59mitotic recombination (GO:0006312)3.10218419
60negative regulation of RNA splicing (GO:0033119)3.09446259
61regulation of nucleobase-containing compound transport (GO:0032239)3.09106436
62DNA replication checkpoint (GO:0000076)3.07221403
63negative regulation of gene silencing (GO:0060969)3.06799222
64positive regulation of meiosis (GO:0045836)3.05862102
65DNA duplex unwinding (GO:0032508)3.05352978
66peptidyl-arginine methylation (GO:0018216)3.04939325
67peptidyl-arginine N-methylation (GO:0035246)3.04939325
68resolution of meiotic recombination intermediates (GO:0000712)3.04739948
69ribosome assembly (GO:0042255)3.04517125
70* mitotic spindle assembly checkpoint (GO:0007094)3.04449934
71mitotic chromosome condensation (GO:0007076)3.04188380
72DNA geometric change (GO:0032392)3.03442624
73* negative regulation of mitotic sister chromatid separation (GO:2000816)3.01054984
74* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01054984
75* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01054984
76* negative regulation of sister chromatid segregation (GO:0033046)3.01054984
77positive regulation of histone methylation (GO:0031062)3.00993909
78* spindle assembly checkpoint (GO:0071173)3.00983416
79translesion synthesis (GO:0019985)3.00552843
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.99497337
81* negative regulation of chromosome segregation (GO:0051985)2.98324856
82histone H4-K16 acetylation (GO:0043984)2.96550063
83protein localization to chromosome, centromeric region (GO:0071459)2.96549969
84telomere maintenance via recombination (GO:0000722)2.94998438
85CENP-A containing nucleosome assembly (GO:0034080)2.94593941
86mitotic sister chromatid cohesion (GO:0007064)2.93626238
87negative regulation of histone methylation (GO:0031061)2.93575376
88histone arginine methylation (GO:0034969)2.92408688
89DNA replication-independent nucleosome assembly (GO:0006336)2.92290754
90DNA replication-independent nucleosome organization (GO:0034724)2.92290754
91ribosomal small subunit assembly (GO:0000028)2.91417149
92chromatin assembly (GO:0031497)2.90302037
93* spindle checkpoint (GO:0031577)2.90273240
94chromatin remodeling at centromere (GO:0031055)2.90124049
95* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89708461
96maturation of SSU-rRNA (GO:0030490)2.89523885
97establishment of integrated proviral latency (GO:0075713)2.88157037
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88137803
99* mitotic spindle checkpoint (GO:0071174)2.88116728
100face development (GO:0060324)2.86903970
101* regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85725051
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85277833
103signal complex assembly (GO:0007172)2.85210047
104intraciliary transport (GO:0042073)2.83189861
105IMP metabolic process (GO:0046040)2.81318221
106gene silencing by RNA (GO:0031047)2.80795624
107sister chromatid segregation (GO:0000819)2.79451897
108* regulation of chromosome segregation (GO:0051983)2.78811656
109* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77373764
110spliceosomal snRNP assembly (GO:0000387)2.75501912
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.74740791
112postreplication repair (GO:0006301)2.74584349
113negative regulation of mRNA processing (GO:0050686)2.73702136
114pre-miRNA processing (GO:0031054)2.73027722
115regulation of DNA damage checkpoint (GO:2000001)2.72260032
116SMAD protein complex assembly (GO:0007183)2.72114372
117establishment of chromosome localization (GO:0051303)2.72061293
118regulation of histone methylation (GO:0031060)2.71861414
119mRNA splicing, via spliceosome (GO:0000398)2.71081814
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71081814
121peptidyl-lysine dimethylation (GO:0018027)2.70845757
122positive regulation of meiotic cell cycle (GO:0051446)2.70246545
123telomere maintenance via telomere lengthening (GO:0010833)2.69708815
124regulation of sister chromatid cohesion (GO:0007063)2.69295776
125RNA splicing, via transesterification reactions (GO:0000375)2.69234004
126histone H2A acetylation (GO:0043968)2.68344713
127nuclear envelope organization (GO:0006998)2.67359572
128viral mRNA export from host cell nucleus (GO:0046784)2.66985271
129ATP-dependent chromatin remodeling (GO:0043044)2.66483985
130translational termination (GO:0006415)2.65404698
131translational initiation (GO:0006413)2.63883202
132regulation of translational fidelity (GO:0006450)2.63590861
133regulation of mitotic spindle organization (GO:0060236)2.62584915
134DNA topological change (GO:0006265)2.62306849
135DNA methylation (GO:0006306)2.61535939
136DNA alkylation (GO:0006305)2.61535939
137kinetochore organization (GO:0051383)2.61223476
138* regulation of mitotic sister chromatid separation (GO:0010965)2.60148486
139* regulation of mitotic sister chromatid segregation (GO:0033047)2.60148486
140* regulation of sister chromatid segregation (GO:0033045)2.60148486
141viral transcription (GO:0019083)2.59811533
142reproductive system development (GO:0061458)2.59601427
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59428187
144cilium or flagellum-dependent cell motility (GO:0001539)2.58867697
145tRNA aminoacylation for protein translation (GO:0006418)2.58648500
146heterochromatin organization (GO:0070828)2.57591496
147female gamete generation (GO:0007292)2.57455043
148metanephric mesenchyme development (GO:0072075)2.57337134
149protein localization to chromosome (GO:0034502)2.57135390
150histone lysine demethylation (GO:0070076)2.56925695
151pyrimidine nucleotide catabolic process (GO:0006244)2.55965260
152translational elongation (GO:0006414)2.55934975
153spindle assembly involved in mitosis (GO:0090307)2.55794694
154regulation of NFAT protein import into nucleus (GO:0051532)2.55448573
155chromatin assembly or disassembly (GO:0006333)2.54806839
156mating behavior (GO:0007617)2.53803548
157histone H4 deacetylation (GO:0070933)2.53742859
158attachment of spindle microtubules to kinetochore (GO:0008608)2.53356693
159dosage compensation (GO:0007549)2.53007198
160histone exchange (GO:0043486)2.52795841
161DNA conformation change (GO:0071103)2.51407454
162regulation of SMAD protein import into nucleus (GO:0060390)2.50955889
163camera-type eye morphogenesis (GO:0048593)2.48912345
164regulation of centrosome cycle (GO:0046605)2.48858355
165amino acid activation (GO:0043038)2.48630082
166hypotonic response (GO:0006971)2.47972466
167histone H4-K12 acetylation (GO:0043983)2.46523024
168motile cilium assembly (GO:0044458)2.44643298
169genitalia morphogenesis (GO:0035112)2.44614429
170establishment of apical/basal cell polarity (GO:0035089)2.44236652
171snRNA transcription (GO:0009301)2.44178974
172regulation of early endosome to late endosome transport (GO:2000641)2.43330442
173chromosome organization (GO:0051276)2.43235059
174positive regulation of gene expression, epigenetic (GO:0045815)2.42680623
175centriole assembly (GO:0098534)2.42184657
176ribosomal large subunit biogenesis (GO:0042273)2.41838984
177nucleus localization (GO:0051647)2.40968971
178negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.40823840
179suckling behavior (GO:0001967)2.39271136
180axonemal dynein complex assembly (GO:0070286)2.38660449
181regulation of double-strand break repair (GO:2000779)2.38261181
182regulation of stem cell maintenance (GO:2000036)2.38216105
183histone demethylation (GO:0016577)2.38086390
184left/right axis specification (GO:0070986)2.32933295
185establishment or maintenance of monopolar cell polarity (GO:0061339)2.31422514
186establishment of monopolar cell polarity (GO:0061162)2.31422514
187regulation of double-strand break repair via homologous recombination (GO:0010569)2.31417086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37824920
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45860411
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.26697894
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77082790
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65178166
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.12791808
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04089605
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03508155
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03451941
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.92048974
11AR_21909140_ChIP-Seq_LNCAP_Human2.88018547
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81802979
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.68755354
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.64748468
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63958230
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51250099
17XRN2_22483619_ChIP-Seq_HELA_Human2.46655140
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34161426
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34045049
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31359045
21* GABP_17652178_ChIP-ChIP_JURKAT_Human2.23637586
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.23589887
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.22609387
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17536452
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.13822902
26ZFX_18555785_ChIP-Seq_MESCs_Mouse2.11987183
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05265313
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03313016
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02197890
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00644418
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00532751
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94336731
33TTF2_22483619_ChIP-Seq_HELA_Human1.91574620
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91382693
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91272958
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90396134
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.88316784
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87783078
39DCP1A_22483619_ChIP-Seq_HELA_Human1.84131614
40* GABP_19822575_ChIP-Seq_HepG2_Human1.80815326
41MYC_22102868_ChIP-Seq_BL_Human1.79706047
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76841806
43* VDR_23849224_ChIP-Seq_CD4+_Human1.75311190
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74459324
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72740866
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71175410
47CIITA_25753668_ChIP-Seq_RAJI_Human1.68589800
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.64816127
49ELK1_19687146_ChIP-ChIP_HELA_Human1.62620097
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60419454
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59672321
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.51636443
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51300885
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50474976
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50201970
56FOXP3_21729870_ChIP-Seq_TREG_Human1.50184184
57CLOCK_20551151_ChIP-Seq_293T_Human1.48649791
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48488094
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47038774
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43957281
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43316440
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43033980
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41177072
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40132356
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39685004
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39541895
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37727246
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35235990
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33196393
70CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32960470
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.30065129
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27946742
73KDM5A_27292631_Chip-Seq_BREAST_Human1.26893218
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25635288
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24617930
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24129838
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22341258
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21608090
79* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20540358
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20274837
81TFEB_21752829_ChIP-Seq_HELA_Human1.19982340
82* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19799218
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19091504
84BRD4_25478319_ChIP-Seq_HGPS_Human1.17479805
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17326011
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17088025
87* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15087779
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15047281
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14613232
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.13933811
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11583852
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09920333
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09914567
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08742234
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07552671
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06612155
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06255201
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.05622524
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05477281
100CHD1_26751641_Chip-Seq_LNCaP_Human1.04483360
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04333261
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04263193
103* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04051993
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03335708
105NFI_21473784_ChIP-Seq_ESCs_Mouse1.01618389
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.01549317
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01170033
108* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01058019
109* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00063344
110NCOR1_26117541_ChIP-Seq_K562_Human0.99945701
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.99182150
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98970785
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.98967317
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98050229
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97681454
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97452736
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95409620
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94872912
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94231357
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93443520
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91452724
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90831287
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.90168887
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89353298
125* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89269689
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88592883
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87051792
128RNF2_27304074_Chip-Seq_NSC_Mouse0.86810857
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.86706801
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86682062
131GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85155356
132SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.82603724
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79184312
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77910687
135KLF4_18555785_Chip-Seq_ESCs_Mouse0.76660303
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.76340880
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75982669
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75181761
139MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74783141
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74322150
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72905810
142FUS_26573619_Chip-Seq_HEK293_Human0.72621035
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72614511
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.71175170
145KDM2B_26808549_Chip-Seq_K562_Human0.70861154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.68905113
2MP0005499_abnormal_olfactory_system3.21605574
3MP0005394_taste/olfaction_phenotype3.21605574
4MP0010030_abnormal_orbit_morphology3.11710480
5MP0003693_abnormal_embryo_hatching3.07379120
6MP0006292_abnormal_olfactory_placode3.06511406
7MP0008438_abnormal_cutaneous_collagen2.86789278
8MP0004957_abnormal_blastocyst_morpholog2.79355333
9MP0000537_abnormal_urethra_morphology2.76008960
10MP0010094_abnormal_chromosome_stability2.68822734
11MP0003941_abnormal_skin_development2.51731473
12MP0003705_abnormal_hypodermis_morpholog2.51570202
13MP0003111_abnormal_nucleus_morphology2.46982211
14MP0008007_abnormal_cellular_replicative2.43992927
15MP0003077_abnormal_cell_cycle2.39228268
16MP0003121_genomic_imprinting2.37830399
17MP0005257_abnormal_intraocular_pressure2.34395471
18MP0006054_spinal_hemorrhage2.33957809
19MP0002210_abnormal_sex_determination2.27775194
20MP0010352_gastrointestinal_tract_polyps2.25878128
21MP0003122_maternal_imprinting2.21992037
22MP0002160_abnormal_reproductive_system2.13264752
23MP0005503_abnormal_tendon_morphology2.11984052
24MP0008932_abnormal_embryonic_tissue1.93236915
25MP0003787_abnormal_imprinting1.90281888
26MP0003942_abnormal_urinary_system1.82777771
27MP0004197_abnormal_fetal_growth/weight/1.80996205
28MP0001730_embryonic_growth_arrest1.78214211
29MP0009053_abnormal_anal_canal1.77586741
30MP0003283_abnormal_digestive_organ1.70220139
31MP0003119_abnormal_digestive_system1.65815906
32MP0000350_abnormal_cell_proliferation1.62793759
33MP0001929_abnormal_gametogenesis1.61151348
34MP0004272_abnormal_basement_membrane1.61047094
35MP0008058_abnormal_DNA_repair1.60942798
36MP0003385_abnormal_body_wall1.59096424
37MP0001145_abnormal_male_reproductive1.59049075
38MP0001697_abnormal_embryo_size1.54567000
39MP0000428_abnormal_craniofacial_morphol1.53899575
40MP0005275_abnormal_skin_tensile1.53895843
41MP0009250_abnormal_appendicular_skeleto1.52900140
42MP0002084_abnormal_developmental_patter1.52451439
43MP0000049_abnormal_middle_ear1.52083235
44MP0002085_abnormal_embryonic_tissue1.51727043
45MP0005380_embryogenesis_phenotype1.50293875
46MP0001672_abnormal_embryogenesis/_devel1.50293875
47MP0003937_abnormal_limbs/digits/tail_de1.47018100
48MP0003890_abnormal_embryonic-extraembry1.46068668
49MP0005666_abnormal_adipose_tissue1.46019135
50MP0004185_abnormal_adipocyte_glucose1.44903739
51MP0003567_abnormal_fetal_cardiomyocyte1.43994852
52MP0003984_embryonic_growth_retardation1.42861421
53MP0002088_abnormal_embryonic_growth/wei1.41885103
54MP0003115_abnormal_respiratory_system1.40569056
55MP0005409_darkened_coat_color1.40495520
56MP0003279_aneurysm1.40083598
57MP0000534_abnormal_ureter_morphology1.37202071
58MP0005174_abnormal_tail_pigmentation1.36057444
59MP0000653_abnormal_sex_gland1.35142392
60MP0002938_white_spotting1.35088657
61MP0002282_abnormal_trachea_morphology1.34516249
62MP0002080_prenatal_lethality1.33913342
63MP0008057_abnormal_DNA_replication1.33816762
64MP0001293_anophthalmia1.28690946
65MP0002111_abnormal_tail_morphology1.27958552
66MP0002086_abnormal_extraembryonic_tissu1.25675421
67MP0003315_abnormal_perineum_morphology1.25148495
68MP0005464_abnormal_platelet_physiology1.24624348
69MP0002932_abnormal_joint_morphology1.23549410
70MP0004233_abnormal_muscle_weight1.22281904
71MP0003755_abnormal_palate_morphology1.20087762
72MP0009384_cardiac_valve_regurgitation1.19081159
73MP0003935_abnormal_craniofacial_develop1.18333205
74MP0003698_abnormal_male_reproductive1.18265287
75MP0000013_abnormal_adipose_tissue1.18197495
76MP0004808_abnormal_hematopoietic_stem1.16815485
77MP0005076_abnormal_cell_differentiation1.15632880
78MP0005508_abnormal_skeleton_morphology1.14316555
79MP0001542_abnormal_bone_strength1.13713940
80MP0005389_reproductive_system_phenotype1.12674735
81MP0005023_abnormal_wound_healing1.11835733
82MP0010368_abnormal_lymphatic_system1.11718228
83MP0002638_abnormal_pupillary_reflex1.11006361
84MP0009672_abnormal_birth_weight1.10340998
85MP0005623_abnormal_meninges_morphology1.10280404
86MP0001661_extended_life_span1.08354411
87MP0000015_abnormal_ear_pigmentation1.06963048
88MP0002396_abnormal_hematopoietic_system1.06358491
89MP0002249_abnormal_larynx_morphology1.05805024
90MP0000733_abnormal_muscle_development1.04682776
91MP0000163_abnormal_cartilage_morphology1.03855842
92MP0002877_abnormal_melanocyte_morpholog1.03540705
93MP0008877_abnormal_DNA_methylation1.03235315
94MP0005220_abnormal_exocrine_pancreas1.02445265
95MP0002116_abnormal_craniofacial_bone1.01577621
96MP0005375_adipose_tissue_phenotype1.00954595
97MP0001958_emphysema0.99145715
98MP0002114_abnormal_axial_skeleton0.99086001
99MP0010307_abnormal_tumor_latency0.99073920
100MP0000432_abnormal_head_morphology0.99051155
101MP0002109_abnormal_limb_morphology0.97022461
102MP0003566_abnormal_cell_adhesion0.95562253
103MP0002971_abnormal_brown_adipose0.94969138
104MP0002233_abnormal_nose_morphology0.94217360
105MP0009703_decreased_birth_body0.93220674
106MP0001915_intracranial_hemorrhage0.92784505
107MP0002697_abnormal_eye_size0.92057092
108MP0000427_abnormal_hair_cycle0.92045866
109MP0001286_abnormal_eye_development0.91692641
110MP0000383_abnormal_hair_follicle0.90906711
111MP0002089_abnormal_postnatal_growth/wei0.89962750
112MP0002113_abnormal_skeleton_development0.89871465
113MP0004264_abnormal_extraembryonic_tissu0.89187967
114MP0004133_heterotaxia0.88896860
115MP0008789_abnormal_olfactory_epithelium0.88176750
116MP0002751_abnormal_autonomic_nervous0.88095660
117MP0009379_abnormal_foot_pigmentation0.87997500
118MP0001119_abnormal_female_reproductive0.87887843
119MP0000490_abnormal_crypts_of0.87527077
120MP0002060_abnormal_skin_morphology0.87234740
121MP0003453_abnormal_keratinocyte_physiol0.86473578
122MP0000778_abnormal_nervous_system0.85684531
123MP0002092_abnormal_eye_morphology0.85607724
124MP0002115_abnormal_skeleton_extremities0.85516009
125MP0008004_abnormal_stomach_pH0.84689012
126MP0000003_abnormal_adipose_tissue0.83606317
127MP0005248_abnormal_Harderian_gland0.83466941
128MP0000678_abnormal_parathyroid_gland0.83230308
129MP0002234_abnormal_pharynx_morphology0.81806197
130MP0000762_abnormal_tongue_morphology0.81661815
131MP0001849_ear_inflammation0.81242884
132MP0003936_abnormal_reproductive_system0.80674439
133MP0002925_abnormal_cardiovascular_devel0.80249928
134MP0000569_abnormal_digit_pigmentation0.80099794
135MP0001879_abnormal_lymphatic_vessel0.79801638
136MP0001299_abnormal_eye_distance/0.79416869
137MP0003861_abnormal_nervous_system0.77523960
138MP0010678_abnormal_skin_adnexa0.77327007
139MP0002177_abnormal_outer_ear0.76804605
140MP0005384_cellular_phenotype0.74885022
141MP0005621_abnormal_cell_physiology0.73377725
142MP0003172_abnormal_lysosome_physiology0.71575308
143MP0003699_abnormal_female_reproductive0.70151415
144MP0009697_abnormal_copulation0.69863093
145MP0006276_abnormal_autonomic_nervous0.69838305

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.36190875
2Abnormality of the lower motor neuron (HP:0002366)3.83594839
3Vertebral arch anomaly (HP:0008438)3.65553943
4Colon cancer (HP:0003003)3.40190492
5Upper motor neuron abnormality (HP:0002127)3.18824199
6Volvulus (HP:0002580)3.17227405
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13416178
8Short 4th metacarpal (HP:0010044)3.13416178
9Premature rupture of membranes (HP:0001788)3.08713011
10Abnormality of the corticospinal tract (HP:0002492)3.00083533
11Hand muscle atrophy (HP:0009130)2.99512218
12Mitral regurgitation (HP:0001653)2.94287955
13Selective tooth agenesis (HP:0001592)2.89511054
14Ectopic kidney (HP:0000086)2.86600714
15Chromsome breakage (HP:0040012)2.81813949
16Ankle contracture (HP:0006466)2.78325599
17Papillary thyroid carcinoma (HP:0002895)2.73375727
18Hepatoblastoma (HP:0002884)2.72935002
19Renal duplication (HP:0000075)2.68439912
20Shallow orbits (HP:0000586)2.66580806
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63404394
22Birth length less than 3rd percentile (HP:0003561)2.62445568
23Male infertility (HP:0003251)2.61334739
24Distal upper limb amyotrophy (HP:0007149)2.52180187
25Upper limb amyotrophy (HP:0009129)2.52180187
2611 pairs of ribs (HP:0000878)2.49486465
27Soft skin (HP:0000977)2.49231827
28Abnormality of the calcaneus (HP:0008364)2.41186355
29Deviation of the thumb (HP:0009603)2.38630034
30Short nail (HP:0001799)2.38043465
31Proximal placement of thumb (HP:0009623)2.33091996
32Rimmed vacuoles (HP:0003805)2.32915256
33Amyotrophic lateral sclerosis (HP:0007354)2.31496635
34Rhabdomyosarcoma (HP:0002859)2.30457519
35Abnormality of the 4th metacarpal (HP:0010012)2.30323194
36Medulloblastoma (HP:0002885)2.27513398
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.27410503
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27410503
39Abnormal respiratory epithelium morphology (HP:0012253)2.27174161
40Abnormal respiratory motile cilium morphology (HP:0005938)2.27174161
41Conjunctival telangiectasia (HP:0000524)2.27139599
42Diastasis recti (HP:0001540)2.24513472
43Abnormality of dentin (HP:0010299)2.19726745
44Ependymoma (HP:0002888)2.18175518
45Increased nuchal translucency (HP:0010880)2.16264514
46Patellar aplasia (HP:0006443)2.15828929
47Broad palm (HP:0001169)2.14535120
48Slender long bone (HP:0003100)2.14447819
49Bladder diverticulum (HP:0000015)2.12111415
50Short 5th finger (HP:0009237)2.11685350
51Chronic bronchitis (HP:0004469)2.11307596
52Pelvic girdle muscle weakness (HP:0003749)2.09346818
53Shoulder girdle muscle weakness (HP:0003547)2.08879492
54Bowel diverticulosis (HP:0005222)2.08510761
55Impaired vibration sensation in the lower limbs (HP:0002166)2.07643460
56Broad long bones (HP:0005622)2.07258294
57Abnormality of the labia minora (HP:0012880)2.07222744
58Biconcave vertebral bodies (HP:0004586)2.06554047
59Aplasia/Hypoplasia of the patella (HP:0006498)2.06511299
60Atresia of the external auditory canal (HP:0000413)2.05882594
61Mesomelia (HP:0003027)2.04738693
62Limb-girdle muscle weakness (HP:0003325)2.04016250
63Irregular epiphyses (HP:0010582)2.03201015
64Abnormality of the anterior horn cell (HP:0006802)2.03014076
65Degeneration of anterior horn cells (HP:0002398)2.03014076
66Gonadotropin excess (HP:0000837)2.02938064
67Ankyloglossia (HP:0010296)2.02582219
68Broad phalanges of the hand (HP:0009768)2.01121264
69Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00719225
70Broad thumb (HP:0011304)2.00646828
71Neonatal short-limb short stature (HP:0008921)2.00620230
72Genu recurvatum (HP:0002816)1.99239701
73Broad phalanx (HP:0006009)1.99238456
74Deep palmar crease (HP:0006191)1.99214701
75Calcaneovalgus deformity (HP:0001848)1.99101528
76Failure to thrive in infancy (HP:0001531)1.98819516
77Cervical subluxation (HP:0003308)1.97995256
78Abnormal ciliary motility (HP:0012262)1.97783160
79Fragile skin (HP:0001030)1.97767067
80Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96688354
81Relative macrocephaly (HP:0004482)1.96054659
82Broad finger (HP:0001500)1.95520629
83Broad distal phalanx of finger (HP:0009836)1.94683348
84Epiphyseal dysplasia (HP:0002656)1.94053413
85Abnormal number of incisors (HP:0011064)1.93724728
86Spinal rigidity (HP:0003306)1.91806295
87Mitral valve prolapse (HP:0001634)1.91707167
88Rhizomelia (HP:0008905)1.91350427
89Abnormality of DNA repair (HP:0003254)1.89901746
90Aortic valve stenosis (HP:0001650)1.89464090
91Aortic dissection (HP:0002647)1.89390446
92Truncal obesity (HP:0001956)1.89128790
93Abnormality of the musculature of the hand (HP:0001421)1.89061605
94Reticulocytopenia (HP:0001896)1.89001027
95Spinal cord lesions (HP:0100561)1.88924388
96Syringomyelia (HP:0003396)1.88924388
97Overgrowth (HP:0001548)1.87681344
98Rectal prolapse (HP:0002035)1.85541016
99Turricephaly (HP:0000262)1.85056762
100Neoplasm of the pancreas (HP:0002894)1.83962579
101Missing ribs (HP:0000921)1.83517955
102Basal cell carcinoma (HP:0002671)1.83170236
103Aortic aneurysm (HP:0004942)1.82367357
104Deformed tarsal bones (HP:0008119)1.82223899
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81820362
106Biliary tract neoplasm (HP:0100574)1.80612856
107Metaphyseal cupping (HP:0003021)1.80354682
108Abnormality of the musculature of the pelvis (HP:0001469)1.80043206
109Abnormality of the hip-girdle musculature (HP:0001445)1.80043206
110Increased density of long bones (HP:0006392)1.79851378
111Atelectasis (HP:0100750)1.79442549
112Progressive external ophthalmoplegia (HP:0000590)1.78982107
113Dilatation of the ascending aorta (HP:0005111)1.78980703
114Embryonal renal neoplasm (HP:0011794)1.78608162
115Heterotopia (HP:0002282)1.78599098
116Asymmetric growth (HP:0100555)1.78219918
117Facial hemangioma (HP:0000329)1.77438773
118Abnormality of the thoracic spine (HP:0100711)1.77334583
119Dynein arm defect of respiratory motile cilia (HP:0012255)1.77100676
120Absent/shortened dynein arms (HP:0200106)1.77100676
121Capillary hemangiomas (HP:0005306)1.76837173
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.76529951
123Wrist flexion contracture (HP:0001239)1.76053046
124Short middle phalanx of the 5th finger (HP:0004220)1.75760009
125Wormian bones (HP:0002645)1.75078747
126Thoracic kyphosis (HP:0002942)1.73265775
127Abnormality of the astrocytes (HP:0100707)1.73099358
128Astrocytoma (HP:0009592)1.73099358
129Joint laxity (HP:0001388)1.73079369
130Glossoptosis (HP:0000162)1.71915754
131Carpal bone hypoplasia (HP:0001498)1.70611511
132Microglossia (HP:0000171)1.70389143
133Nephroblastoma (Wilms tumor) (HP:0002667)1.70066795
134Blue sclerae (HP:0000592)1.69687069
135Intestinal polyp (HP:0005266)1.68655763
136Abnormal respiratory motile cilium physiology (HP:0012261)1.67798915
137Metaphyseal dysplasia (HP:0100255)1.67610111
138Increased variability in muscle fiber diameter (HP:0003557)1.67470210
139Microretrognathia (HP:0000308)1.67323692
140Breast hypoplasia (HP:0003187)1.67221097
141Hip dysplasia (HP:0001385)1.67024930
142Horizontal nystagmus (HP:0000666)1.66333600
143Neonatal hypoglycemia (HP:0001998)1.66249270
144High anterior hairline (HP:0009890)1.66048430
145Optic nerve coloboma (HP:0000588)1.65804966
146Glioma (HP:0009733)1.65558823
147Deviation of the hallux (HP:0010051)1.64283573
148Intestinal polyposis (HP:0200008)1.63811995
149Rhinitis (HP:0012384)1.63538639
150Pseudobulbar signs (HP:0002200)1.63238361
151Atrophic scars (HP:0001075)1.63235896
152High pitched voice (HP:0001620)1.62818400
153Thoracolumbar scoliosis (HP:0002944)1.62584150
154Infertility (HP:0000789)1.62326558
155Broad metatarsal (HP:0001783)1.62197032
156Overlapping toe (HP:0001845)1.61974873
157Mild short stature (HP:0003502)1.61774922
158Neoplasm of the adrenal cortex (HP:0100641)1.61498625
159Abnormality of cochlea (HP:0000375)1.60659102
160Large hands (HP:0001176)1.60578190
161Recurrent sinusitis (HP:0011108)1.59360642
162Abnormality of the acetabulum (HP:0003170)1.59164683
163Lip pit (HP:0100267)1.59032873
164Abnormal lung lobation (HP:0002101)1.58652479
165Ovarian neoplasm (HP:0100615)1.58297697
166Broad toe (HP:0001837)1.58137709
167Hallux valgus (HP:0001822)1.56806914
168Radial bowing (HP:0002986)1.56209068
169Exostoses (HP:0100777)1.55414488
170Vitreoretinal degeneration (HP:0000655)1.55286990
171Abnormality of abdominal situs (HP:0011620)1.55058051
172Abdominal situs inversus (HP:0003363)1.55058051
173Carpal synostosis (HP:0009702)1.54083172
174Abnormality of the phalanges of the hallux (HP:0010057)1.53242611
175Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.53044304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.85853493
2CDK194.01489524
3BUB13.66314973
4CDC73.51944655
5CAMK1G3.51570805
6WEE13.35046680
7BMX2.81708737
8PASK2.76396427
9PKN22.73830762
10EIF2AK12.42014747
11SCYL22.39824254
12PRKD32.32733399
13PTK2B2.27219500
14TGFBR12.25611957
15ACVR1B2.23128379
16NEK22.13965692
17SRPK12.10800065
18MKNK12.10352277
19TRIB32.05536637
20TAF12.01586012
21NEK11.94746077
22BRSK21.92468496
23FLT31.81520515
24TTK1.80375190
25RPS6KA41.75895947
26EIF2AK31.74753310
27ERBB31.68896849
28DYRK31.67150008
29FGR1.64232887
30LATS21.64169283
31PLK31.62880021
32EEF2K1.56101820
33* PLK11.50206079
34RPS6KB21.48489369
35MAP3K131.47615532
36CSF1R1.47576593
37LATS11.44118082
38AURKB1.42998111
39MAP3K101.42708215
40ATR1.42256906
41PDGFRB1.41248420
42CASK1.39012217
43PAK41.38606303
44MAP3K81.33400433
45DMPK1.32825119
46BMPR1B1.32273607
47DDR21.31437659
48PDGFRA1.30209851
49MKNK21.28632725
50TESK21.26228947
51CDK71.24680941
52TLK11.21006180
53TSSK61.20926691
54TESK11.20238933
55PRPF4B1.20012613
56CHEK21.19290653
57FGFR11.12624270
58BRSK11.12027906
59NTRK11.07951429
60LIMK11.07629766
61LRRK21.05966838
62MAP3K21.04644498
63STK241.04265184
64PAK21.03578697
65EPHA21.03523634
66WNK11.02989755
67CDK81.01908055
68AURKA1.01689730
69KSR21.00216882
70RIPK40.99413690
71NME20.98647147
72CDK40.98050525
73PTK60.98030483
74STK38L0.97356142
75KSR10.94713433
76CHEK10.94501463
77STK380.93441955
78KDR0.92934791
79VRK10.92667218
80NEK90.91437956
81CDK90.89796589
82MAP3K30.89776044
83TAOK20.89649924
84CDK30.88322424
85DYRK1B0.87632817
86TTN0.85691218
87EPHB20.84659982
88ILK0.84480028
89TYRO30.79503947
90ZAK0.78345505
91PLK40.77702144
92RET0.77597770
93CDK60.77208571
94NLK0.76254914
95STK30.75378965
96SMG10.72450584
97MAP2K30.71706852
98MAP3K40.71689492
99FER0.70320570
100CDK20.69874784
101MTOR0.69856186
102ATM0.68351920
103CCNB10.67179993
104BCKDK0.66899436
105DYRK1A0.65557535
106MAP3K60.65287190
107STK100.64887690
108* CSNK1E0.64201020
109TEC0.61482534
110MELK0.60953217
111DYRK20.60856116
112PAK10.59802939
113YES10.57892362
114MARK20.57461307
115* CDK10.56273813
116MAP3K90.53482187
117SGK10.52652000
118STK160.52525887
119PDK20.51456205
120CDK120.51389734
121PTK20.50634653
122OXSR10.50065451
123MOS0.49226921
124RIPK10.46272041
125MYLK0.46121018
126STK110.45416248
127CDK11A0.45296323
128PRKD20.45066631
129MAP2K20.44427212
130HIPK20.43740412
131MAPKAPK30.42727837
132BTK0.42718921
133CAMK10.42180614
134CSNK2A10.41900170
135PRKCI0.41556589
136NTRK30.41242127
137ARAF0.41202077
138CDC42BPA0.40794412
139CSNK2A20.40694588
140RPS6KB10.40655080
141PIK3CG0.39649873
142BRD40.39173492
143ALK0.38896098
144BRAF0.38746715
145FGFR30.38112139
146AKT20.37800306
147STK40.35362364
148GSK3B0.33585158
149ROCK10.33331159
150* PRKDC0.31991225
151MET0.31727425
152SIK10.31264535
153ERBB20.30044245
154CDK140.29879845
155AKT10.28555875
156PLK20.26114093
157RPS6KA50.24765988

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39891223
2Mismatch repair_Homo sapiens_hsa034303.70053150
3Spliceosome_Homo sapiens_hsa030403.37303597
4* Cell cycle_Homo sapiens_hsa041103.24410581
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01788896
6RNA transport_Homo sapiens_hsa030133.00396653
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64917776
8Nucleotide excision repair_Homo sapiens_hsa034202.60053795
9Base excision repair_Homo sapiens_hsa034102.52839324
10Proteasome_Homo sapiens_hsa030502.42148539
11Ribosome_Homo sapiens_hsa030102.40173673
12One carbon pool by folate_Homo sapiens_hsa006702.34301715
13Homologous recombination_Homo sapiens_hsa034402.24101626
14RNA polymerase_Homo sapiens_hsa030201.96898054
15Dorso-ventral axis formation_Homo sapiens_hsa043201.96834625
16RNA degradation_Homo sapiens_hsa030181.87835920
17Pyrimidine metabolism_Homo sapiens_hsa002401.87263850
18p53 signaling pathway_Homo sapiens_hsa041151.82544576
19mRNA surveillance pathway_Homo sapiens_hsa030151.81444732
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78924668
21Non-homologous end-joining_Homo sapiens_hsa034501.46613069
22Basal cell carcinoma_Homo sapiens_hsa052171.41542979
23Hippo signaling pathway_Homo sapiens_hsa043901.41278439
24Fanconi anemia pathway_Homo sapiens_hsa034601.40979161
25* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40390706
26ErbB signaling pathway_Homo sapiens_hsa040121.40155633
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38022449
28Basal transcription factors_Homo sapiens_hsa030221.37603655
29Systemic lupus erythematosus_Homo sapiens_hsa053221.32798582
30* Oocyte meiosis_Homo sapiens_hsa041141.30258528
31* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28542090
32Thyroid cancer_Homo sapiens_hsa052161.25442128
33Viral carcinogenesis_Homo sapiens_hsa052031.24918666
34Bladder cancer_Homo sapiens_hsa052191.24189867
35Small cell lung cancer_Homo sapiens_hsa052221.21027277
36MicroRNAs in cancer_Homo sapiens_hsa052061.20955151
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20902247
38Hedgehog signaling pathway_Homo sapiens_hsa043401.17145447
39N-Glycan biosynthesis_Homo sapiens_hsa005101.16849258
40TGF-beta signaling pathway_Homo sapiens_hsa043501.16617022
41Protein export_Homo sapiens_hsa030601.15708367
42ECM-receptor interaction_Homo sapiens_hsa045121.15534478
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15057629
44* HTLV-I infection_Homo sapiens_hsa051661.13926354
45Colorectal cancer_Homo sapiens_hsa052101.13144252
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07512268
47Choline metabolism in cancer_Homo sapiens_hsa052311.06397138
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04632654
49Renal cell carcinoma_Homo sapiens_hsa052111.03961312
50Adherens junction_Homo sapiens_hsa045201.03060237
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03003179
52Epstein-Barr virus infection_Homo sapiens_hsa051691.00677880
53B cell receptor signaling pathway_Homo sapiens_hsa046621.00025996
54Selenocompound metabolism_Homo sapiens_hsa004500.99982043
55Purine metabolism_Homo sapiens_hsa002300.99863685
56Amoebiasis_Homo sapiens_hsa051460.97157328
57Alcoholism_Homo sapiens_hsa050340.95226460
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.94515259
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.92258445
60Proteoglycans in cancer_Homo sapiens_hsa052050.90337344
61Focal adhesion_Homo sapiens_hsa045100.90150098
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.88116324
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88105683
64Acute myeloid leukemia_Homo sapiens_hsa052210.87510918
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84170415
66Wnt signaling pathway_Homo sapiens_hsa043100.83433670
67Notch signaling pathway_Homo sapiens_hsa043300.82580405
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78674373
69Chronic myeloid leukemia_Homo sapiens_hsa052200.78387482
70Protein digestion and absorption_Homo sapiens_hsa049740.77035022
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.76603152
72Dilated cardiomyopathy_Homo sapiens_hsa054140.74674186
73VEGF signaling pathway_Homo sapiens_hsa043700.74585036
74Pyruvate metabolism_Homo sapiens_hsa006200.74139172
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.73474211
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73300836
77Pathways in cancer_Homo sapiens_hsa052000.69998265
78Biosynthesis of amino acids_Homo sapiens_hsa012300.69151570
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68176989
80Gap junction_Homo sapiens_hsa045400.66392522
81Other glycan degradation_Homo sapiens_hsa005110.66222216
82Platelet activation_Homo sapiens_hsa046110.65480883
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65223146
84Pentose phosphate pathway_Homo sapiens_hsa000300.63200727
85Prostate cancer_Homo sapiens_hsa052150.62599886
86Herpes simplex infection_Homo sapiens_hsa051680.61507527
87Endometrial cancer_Homo sapiens_hsa052130.60695587
88Folate biosynthesis_Homo sapiens_hsa007900.60078634
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57796772
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56625964
91Retinol metabolism_Homo sapiens_hsa008300.56488721
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56334960
93Shigellosis_Homo sapiens_hsa051310.54720635
94Tight junction_Homo sapiens_hsa045300.54662176
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54432667
96mTOR signaling pathway_Homo sapiens_hsa041500.53998637
97Antigen processing and presentation_Homo sapiens_hsa046120.52700744
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.52571312
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.52285024
100Regulation of autophagy_Homo sapiens_hsa041400.51950658
101Endocytosis_Homo sapiens_hsa041440.51816241
102Melanoma_Homo sapiens_hsa052180.51729256
103HIF-1 signaling pathway_Homo sapiens_hsa040660.49126105
104Ras signaling pathway_Homo sapiens_hsa040140.49079194
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48889126
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48617591
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47805466
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47001480
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46750623
110Axon guidance_Homo sapiens_hsa043600.46374801
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46177492
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45471920
113Hepatitis B_Homo sapiens_hsa051610.44812263
114Galactose metabolism_Homo sapiens_hsa000520.43991758
115Viral myocarditis_Homo sapiens_hsa054160.43592968
116Legionellosis_Homo sapiens_hsa051340.43210349
117Pancreatic cancer_Homo sapiens_hsa052120.40188844
118Sulfur relay system_Homo sapiens_hsa041220.39393040
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37236011
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36422975
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.36416238
122Non-small cell lung cancer_Homo sapiens_hsa052230.35729128
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35576017
124Carbon metabolism_Homo sapiens_hsa012000.34667163
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.33177170
126Lysine degradation_Homo sapiens_hsa003100.32886876
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.31517107
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28138689
129FoxO signaling pathway_Homo sapiens_hsa040680.27645613
130Melanogenesis_Homo sapiens_hsa049160.26524961
131AMPK signaling pathway_Homo sapiens_hsa041520.24934910
132Glioma_Homo sapiens_hsa052140.23183405
133Apoptosis_Homo sapiens_hsa042100.22913087
134Glutathione metabolism_Homo sapiens_hsa004800.20343534
135Rap1 signaling pathway_Homo sapiens_hsa040150.19686862
136Insulin signaling pathway_Homo sapiens_hsa049100.19434960

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