CDC20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.20832194
2protein localization to kinetochore (GO:0034501)4.91550940
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.82564121
4establishment of integrated proviral latency (GO:0075713)4.73125884
5mitotic sister chromatid segregation (GO:0000070)4.65846438
6regulation of spindle organization (GO:0090224)4.60716583
7protein localization to chromosome, centromeric region (GO:0071459)4.48305737
8nucleobase biosynthetic process (GO:0046112)4.40115153
9metaphase plate congression (GO:0051310)4.37807612
10purine nucleobase biosynthetic process (GO:0009113)4.29415080
11mitotic nuclear envelope disassembly (GO:0007077)4.29377339
12DNA strand elongation involved in DNA replication (GO:0006271)4.29297549
13DNA replication initiation (GO:0006270)4.28649018
14DNA unwinding involved in DNA replication (GO:0006268)4.23352848
15DNA topological change (GO:0006265)4.23104852
16ribosome assembly (GO:0042255)4.20331295
17sister chromatid segregation (GO:0000819)4.14327036
18DNA replication checkpoint (GO:0000076)4.12916594
19DNA strand elongation (GO:0022616)4.06011971
20DNA ligation (GO:0006266)4.05117694
21formation of translation preinitiation complex (GO:0001731)4.02765357
22establishment of chromosome localization (GO:0051303)4.02090789
23chromosome condensation (GO:0030261)4.00339587
24nuclear envelope disassembly (GO:0051081)3.97591912
25membrane disassembly (GO:0030397)3.97591912
26regulation of mitotic spindle organization (GO:0060236)3.94046439
27DNA replication-dependent nucleosome organization (GO:0034723)3.92580873
28DNA replication-dependent nucleosome assembly (GO:0006335)3.92580873
29positive regulation of chromosome segregation (GO:0051984)3.89974865
30kinetochore organization (GO:0051383)3.88680951
31maturation of SSU-rRNA (GO:0030490)3.86919674
32CENP-A containing nucleosome assembly (GO:0034080)3.82729011
33telomere maintenance via semi-conservative replication (GO:0032201)3.79192651
34chromatin remodeling at centromere (GO:0031055)3.77513902
35kinetochore assembly (GO:0051382)3.74103074
36ribosome biogenesis (GO:0042254)3.73760276
37mitotic chromosome condensation (GO:0007076)3.72485558
38establishment of viral latency (GO:0019043)3.70692129
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70660967
40nuclear pore organization (GO:0006999)3.68942452
41attachment of spindle microtubules to kinetochore (GO:0008608)3.67693616
42* regulation of chromosome segregation (GO:0051983)3.60567378
43* spindle checkpoint (GO:0031577)3.55670419
44DNA replication-independent nucleosome organization (GO:0034724)3.55190353
45DNA replication-independent nucleosome assembly (GO:0006336)3.55190353
46DNA deamination (GO:0045006)3.52014094
47folic acid-containing compound biosynthetic process (GO:0009396)3.48256786
48* negative regulation of chromosome segregation (GO:0051985)3.47495876
49spliceosomal snRNP assembly (GO:0000387)3.47321685
50DNA packaging (GO:0006323)3.43909552
51* negative regulation of mitotic sister chromatid separation (GO:2000816)3.40099052
52* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40099052
53* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40099052
54* negative regulation of sister chromatid segregation (GO:0033046)3.40099052
55histone exchange (GO:0043486)3.37630503
56telomere maintenance via recombination (GO:0000722)3.36574341
57regulation of centrosome cycle (GO:0046605)3.36562669
58* mitotic spindle checkpoint (GO:0071174)3.36005793
59protein localization to chromosome (GO:0034502)3.35629360
60ribonucleoprotein complex biogenesis (GO:0022613)3.35469486
61* spindle assembly checkpoint (GO:0071173)3.35343218
62* mitotic spindle assembly checkpoint (GO:0007094)3.34579675
63ventricular cardiac muscle cell development (GO:0055015)3.33192354
64* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33032114
65* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32016190
66heterochromatin organization (GO:0070828)3.32012302
67nuclear pore complex assembly (GO:0051292)3.30929491
68mitotic recombination (GO:0006312)3.30073125
69IMP biosynthetic process (GO:0006188)3.29813475
70pore complex assembly (GO:0046931)3.29598299
71folic acid metabolic process (GO:0046655)3.26970571
72telomere maintenance via telomere lengthening (GO:0010833)3.25786285
73* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24601206
74regulation of translational fidelity (GO:0006450)3.24256494
75ribosomal large subunit biogenesis (GO:0042273)3.22716698
76nuclear envelope organization (GO:0006998)3.21364438
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20378011
78mitotic sister chromatid cohesion (GO:0007064)3.20056787
79nucleobase-containing small molecule interconversion (GO:0015949)3.18885777
80* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18758495
81rRNA processing (GO:0006364)3.16616457
82regulation of sister chromatid cohesion (GO:0007063)3.13602614
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11376349
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11376349
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.11376349
86regulation of telomere maintenance via telomerase (GO:0032210)3.11149025
87* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10692974
88chromosome segregation (GO:0007059)3.09301135
89proteasome assembly (GO:0043248)3.09073219
90ribosomal small subunit biogenesis (GO:0042274)3.08671979
91* regulation of sister chromatid segregation (GO:0033045)3.07642713
92* regulation of mitotic sister chromatid separation (GO:0010965)3.07642713
93* regulation of mitotic sister chromatid segregation (GO:0033047)3.07642713
94rRNA metabolic process (GO:0016072)3.07168825
95regulation of gene silencing by RNA (GO:0060966)3.04874295
96regulation of posttranscriptional gene silencing (GO:0060147)3.04874295
97regulation of gene silencing by miRNA (GO:0060964)3.04874295
98regulation of translational termination (GO:0006449)3.04361074
99* negative regulation of ligase activity (GO:0051352)3.02984428
100* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02984428
101* mitotic cell cycle (GO:0000278)3.02946333
102DNA conformation change (GO:0071103)3.02482270
103ATP-dependent chromatin remodeling (GO:0043044)3.02103381
104* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01886834
105translational initiation (GO:0006413)3.01089798
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.98824455
107* negative regulation of mitosis (GO:0045839)2.97662868
108nucleotide-excision repair, DNA gap filling (GO:0006297)2.96400476
109protein complex localization (GO:0031503)2.95766287
110ribosomal small subunit assembly (GO:0000028)2.95183890
111* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94992927
112DNA duplex unwinding (GO:0032508)2.94922367
113cellular protein complex localization (GO:0034629)2.94730862
114chromatin assembly or disassembly (GO:0006333)2.94497874
115mitotic cytokinesis (GO:0000281)2.93971662
116DNA geometric change (GO:0032392)2.93848717
117histone-serine phosphorylation (GO:0035404)2.93470234
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.91725425
119viral mRNA export from host cell nucleus (GO:0046784)2.91698538
120rRNA modification (GO:0000154)2.87593651
121protein K6-linked ubiquitination (GO:0085020)2.87462596
122microtubule depolymerization (GO:0007019)2.86867892
123spliceosomal complex assembly (GO:0000245)2.86726675
124translational termination (GO:0006415)2.86428961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74264608
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.54391738
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.18357791
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73848077
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54560623
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53841622
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10251649
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89441672
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81963192
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.77595611
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77459023
12* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71367116
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.70111345
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66556263
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63727149
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.50280166
17AR_21909140_ChIP-Seq_LNCAP_Human2.46432017
18* XRN2_22483619_ChIP-Seq_HELA_Human2.37681213
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35635090
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17687515
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13823100
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07695056
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06150953
24VDR_23849224_ChIP-Seq_CD4+_Human2.01830658
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00346550
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98200970
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95384008
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.90323889
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89718051
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89465766
31DCP1A_22483619_ChIP-Seq_HELA_Human1.80479594
32FOXP3_21729870_ChIP-Seq_TREG_Human1.79194465
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.78377910
34GABP_19822575_ChIP-Seq_HepG2_Human1.77430061
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76538587
36TTF2_22483619_ChIP-Seq_HELA_Human1.72218577
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71020125
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70331952
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68219935
40CIITA_25753668_ChIP-Seq_RAJI_Human1.56929574
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52061464
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51917983
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.51491118
44MYC_22102868_ChIP-Seq_BL_Human1.51444115
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50982711
46KDM5A_27292631_Chip-Seq_BREAST_Human1.47090566
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45405067
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43186490
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41853686
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39312487
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38377699
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37593458
53* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35720686
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35543593
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.31744788
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31643292
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29676356
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29432987
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29210221
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26333155
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24958346
62ELK1_19687146_ChIP-ChIP_HELA_Human1.24568252
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24480072
64* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21869023
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21248030
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18593714
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16133397
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14112459
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13719682
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13719682
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13719682
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12637768
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12092014
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11954028
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11504346
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05619261
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04876946
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.04770485
79TFEB_21752829_ChIP-Seq_HELA_Human1.04362069
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.03815651
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03559114
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03277791
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01103989
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00643679
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97695772
86SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97458190
87OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96620731
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93713267
89* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93321977
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93064078
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92340709
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92011930
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91526252
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89224417
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89222095
96ZNF263_19887448_ChIP-Seq_K562_Human0.88094147
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86329284
98* VDR_21846776_ChIP-Seq_THP-1_Human0.86317660
99CHD1_26751641_Chip-Seq_LNCaP_Human0.85901635
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85532037
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85495224
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85172710
103MYC_18940864_ChIP-ChIP_HL60_Human0.84775051
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84684766
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84142149
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83163517
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82892588
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82696648
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82461592
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82324724
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81720843
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81353480
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78448564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.11331154
2* MP0003111_abnormal_nucleus_morphology5.08887326
3MP0004957_abnormal_blastocyst_morpholog4.58160052
4MP0010094_abnormal_chromosome_stability4.46902769
5* MP0003077_abnormal_cell_cycle4.16909056
6MP0008057_abnormal_DNA_replication3.38119265
7MP0008932_abnormal_embryonic_tissue2.98312893
8MP0008058_abnormal_DNA_repair2.90054048
9MP0008007_abnormal_cellular_replicative2.83113196
10MP0010030_abnormal_orbit_morphology2.73185839
11MP0001730_embryonic_growth_arrest2.69826855
12MP0003123_paternal_imprinting2.50536538
13* MP0000350_abnormal_cell_proliferation2.33578582
14MP0010352_gastrointestinal_tract_polyps2.10470647
15MP0001672_abnormal_embryogenesis/_devel2.03614714
16MP0005380_embryogenesis_phenotype2.03614714
17MP0002877_abnormal_melanocyte_morpholog2.02096937
18MP0010307_abnormal_tumor_latency1.96466929
19MP0003786_premature_aging1.94537074
20MP0000566_synostosis1.91410631
21* MP0001697_abnormal_embryo_size1.90095988
22MP0002085_abnormal_embryonic_tissue1.80020471
23MP0003984_embryonic_growth_retardation1.78692294
24* MP0002080_prenatal_lethality1.77147626
25MP0008877_abnormal_DNA_methylation1.75882389
26MP0002088_abnormal_embryonic_growth/wei1.74828801
27* MP0003718_maternal_effect1.72962337
28MP0009697_abnormal_copulation1.72256795
29MP0002084_abnormal_developmental_patter1.68613436
30MP0002396_abnormal_hematopoietic_system1.56127717
31MP0002086_abnormal_extraembryonic_tissu1.56125881
32MP0006292_abnormal_olfactory_placode1.55175175
33MP0001293_anophthalmia1.46240817
34MP0004197_abnormal_fetal_growth/weight/1.44623790
35MP0000490_abnormal_crypts_of1.43343298
36* MP0000313_abnormal_cell_death1.39116628
37MP0003941_abnormal_skin_development1.38897903
38MP0000537_abnormal_urethra_morphology1.32733132
39MP0002653_abnormal_ependyma_morphology1.32026107
40MP0003567_abnormal_fetal_cardiomyocyte1.31734073
41MP0005076_abnormal_cell_differentiation1.29925240
42MP0001346_abnormal_lacrimal_gland1.28783456
43MP0003119_abnormal_digestive_system1.28089675
44MP0002210_abnormal_sex_determination1.25522309
45MP0009053_abnormal_anal_canal1.25257646
46MP0002697_abnormal_eye_size1.23137925
47* MP0002019_abnormal_tumor_incidence1.23079002
48MP0003315_abnormal_perineum_morphology1.22939648
49MP0005623_abnormal_meninges_morphology1.22567029
50MP0004185_abnormal_adipocyte_glucose1.18816140
51MP0006035_abnormal_mitochondrial_morpho1.16034821
52MP0003806_abnormal_nucleotide_metabolis1.16004719
53MP0001145_abnormal_male_reproductive1.15289733
54MP0003937_abnormal_limbs/digits/tail_de1.14768434
55MP0002102_abnormal_ear_morphology1.13225400
56MP0004133_heterotaxia1.13096536
57MP0000428_abnormal_craniofacial_morphol1.12245623
58MP0009379_abnormal_foot_pigmentation1.07638835
59MP0004808_abnormal_hematopoietic_stem1.06056541
60MP0010234_abnormal_vibrissa_follicle1.05646134
61MP0002796_impaired_skin_barrier1.04380855
62MP0002111_abnormal_tail_morphology1.03181042
63MP0003283_abnormal_digestive_organ1.01787766
64* MP0001929_abnormal_gametogenesis1.01602766
65MP0003121_genomic_imprinting0.99714113
66MP0009333_abnormal_splenocyte_physiolog0.99263617
67MP0002938_white_spotting0.99072941
68MP0002160_abnormal_reproductive_system0.96965004
69MP0001545_abnormal_hematopoietic_system0.95716870
70MP0005397_hematopoietic_system_phenotyp0.95716870
71MP0001661_extended_life_span0.95339972
72MP0000653_abnormal_sex_gland0.94285471
73MP0002092_abnormal_eye_morphology0.93703328
74MP0009672_abnormal_birth_weight0.91888215
75MP0003890_abnormal_embryonic-extraembry0.91397121
76MP0003186_abnormal_redox_activity0.90178924
77MP0000358_abnormal_cell_content/0.89803667
78MP0003938_abnormal_ear_development0.89463620
79MP0003705_abnormal_hypodermis_morpholog0.88279440
80MP0000762_abnormal_tongue_morphology0.87032079
81MP0001727_abnormal_embryo_implantation0.86540507
82MP0003385_abnormal_body_wall0.86489418
83MP0005377_hearing/vestibular/ear_phenot0.85765519
84MP0003878_abnormal_ear_physiology0.85765519
85MP0009840_abnormal_foam_cell0.83242739
86MP0005384_cellular_phenotype0.80800122
87MP0009278_abnormal_bone_marrow0.80717316
88MP0005621_abnormal_cell_physiology0.80218705
89MP0003115_abnormal_respiratory_system0.80083041
90MP0000703_abnormal_thymus_morphology0.79688941
91MP0005389_reproductive_system_phenotype0.79001182
92MP0005451_abnormal_body_composition0.78675776
93MP0005023_abnormal_wound_healing0.78318095
94MP0000579_abnormal_nail_morphology0.76185622
95MP0006036_abnormal_mitochondrial_physio0.76121817
96MP0002234_abnormal_pharynx_morphology0.74711649
97MP0002163_abnormal_gland_morphology0.72958422
98MP0000678_abnormal_parathyroid_gland0.72706219
99MP0001286_abnormal_eye_development0.72594705
100MP0004272_abnormal_basement_membrane0.72009321
101MP0001849_ear_inflammation0.71927143
102MP0008260_abnormal_autophagy0.69726440
103MP0002233_abnormal_nose_morphology0.69561785
104MP0002060_abnormal_skin_morphology0.69296705
105MP0000750_abnormal_muscle_regeneration0.69193764
106MP0001119_abnormal_female_reproductive0.68241152
107MP0000049_abnormal_middle_ear0.68052444
108MP0001881_abnormal_mammary_gland0.67225250
109MP0009703_decreased_birth_body0.67164581
110MP0008789_abnormal_olfactory_epithelium0.66519936
111MP0003942_abnormal_urinary_system0.65852972
112MP0002722_abnormal_immune_system0.65578029
113MP0003221_abnormal_cardiomyocyte_apopto0.65224331
114MP0005257_abnormal_intraocular_pressure0.63714700
115MP0002132_abnormal_respiratory_system0.63195830
116MP0001529_abnormal_vocalization0.63004105
117MP0003755_abnormal_palate_morphology0.62112099
118MP0000733_abnormal_muscle_development0.62051832
119MP0000432_abnormal_head_morphology0.61661599
120MP0001915_intracranial_hemorrhage0.61484363
121MP0000858_altered_metastatic_potential0.61127002
122MP0002249_abnormal_larynx_morphology0.60764839
123* MP0003699_abnormal_female_reproductive0.60567259
124MP0003861_abnormal_nervous_system0.60500365
125MP0000477_abnormal_intestine_morphology0.59565218
126MP0003566_abnormal_cell_adhesion0.58778094
127MP0002089_abnormal_postnatal_growth/wei0.58610262
128MP0003935_abnormal_craniofacial_develop0.58221841
129MP0004233_abnormal_muscle_weight0.57588705
130MP0005501_abnormal_skin_physiology0.57483520
131MP0004264_abnormal_extraembryonic_tissu0.56076108

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.67964216
2Breast hypoplasia (HP:0003187)4.56499834
3Carpal bone hypoplasia (HP:0001498)3.91031436
4Absent radius (HP:0003974)3.78574893
5Reticulocytopenia (HP:0001896)3.60454972
6Patellar aplasia (HP:0006443)3.59840082
7Aplasia involving forearm bones (HP:0009822)3.56793639
8Absent forearm bone (HP:0003953)3.56793639
9Aplasia/Hypoplasia of the patella (HP:0006498)3.48716885
10Selective tooth agenesis (HP:0001592)3.42291596
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.39764620
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33511269
13Impulsivity (HP:0100710)3.26968386
14Chromsome breakage (HP:0040012)3.25628201
15Rough bone trabeculation (HP:0100670)3.24285721
16Abnormality of the anterior horn cell (HP:0006802)3.18890029
17Degeneration of anterior horn cells (HP:0002398)3.18890029
18Cerebral hypomyelination (HP:0006808)3.18742931
19Oral leukoplakia (HP:0002745)3.14314454
20Ependymoma (HP:0002888)3.10480897
21Meckel diverticulum (HP:0002245)3.05206851
22Microvesicular hepatic steatosis (HP:0001414)2.95487902
23Abnormality of the ileum (HP:0001549)2.91921064
24Cortical dysplasia (HP:0002539)2.85217429
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.84760657
26Abnormality of the preputium (HP:0100587)2.83120660
27Colon cancer (HP:0003003)2.82912606
28Abnormality of cells of the erythroid lineage (HP:0012130)2.78202202
29Small intestinal stenosis (HP:0012848)2.77811808
30Duodenal stenosis (HP:0100867)2.77811808
31Broad distal phalanx of finger (HP:0009836)2.75997723
32Absent thumb (HP:0009777)2.74455554
33Trismus (HP:0000211)2.74362537
34Abnormality of chromosome stability (HP:0003220)2.65011084
35Medulloblastoma (HP:0002885)2.64657972
36Abnormality of glycolysis (HP:0004366)2.64577586
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.64283754
38Premature ovarian failure (HP:0008209)2.62143479
39Abnormal number of erythroid precursors (HP:0012131)2.61130767
40Nephroblastoma (Wilms tumor) (HP:0002667)2.59680199
41Abnormality of the labia minora (HP:0012880)2.58760680
42Increased nuchal translucency (HP:0010880)2.57958752
43Neoplasm of the pancreas (HP:0002894)2.51266343
44Abnormal gallbladder physiology (HP:0012438)2.44901325
45Cholecystitis (HP:0001082)2.44901325
46Atresia of the external auditory canal (HP:0000413)2.44410648
47Embryonal renal neoplasm (HP:0011794)2.41497836
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40073374
49Progressive muscle weakness (HP:0003323)2.38254224
50Secondary amenorrhea (HP:0000869)2.35525558
51Microretrognathia (HP:0000308)2.35273566
52Horseshoe kidney (HP:0000085)2.34635548
53Triphalangeal thumb (HP:0001199)2.33256718
54Abnormality of the duodenum (HP:0002246)2.33050093
55Supernumerary spleens (HP:0009799)2.32927100
56Abnormal number of incisors (HP:0011064)2.32847964
57High anterior hairline (HP:0009890)2.32485453
58Proximal placement of thumb (HP:0009623)2.31475724
59Agnosia (HP:0010524)2.30128316
60Ureteral duplication (HP:0000073)2.29058985
61Increased serum pyruvate (HP:0003542)2.28497346
62Macrocytic anemia (HP:0001972)2.26445358
63Abnormal trabecular bone morphology (HP:0100671)2.25930330
64Myelodysplasia (HP:0002863)2.25305101
65Multiple enchondromatosis (HP:0005701)2.23240532
66Bone marrow hypocellularity (HP:0005528)2.22913419
67Aplasia/hypoplasia of the humerus (HP:0006507)2.21294905
6811 pairs of ribs (HP:0000878)2.20288252
69Sloping forehead (HP:0000340)2.20082402
70Deviation of the thumb (HP:0009603)2.18797622
71Rhabdomyosarcoma (HP:0002859)2.16609177
72Facial cleft (HP:0002006)2.15429232
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.13832676
74Hypoplasia of the radius (HP:0002984)2.13545955
75Tracheoesophageal fistula (HP:0002575)2.12737545
76Duplicated collecting system (HP:0000081)2.11195102
77Abnormal lung lobation (HP:0002101)2.06757018
78Glioma (HP:0009733)2.06626538
79Premature graying of hair (HP:0002216)2.06154255
80Ectopic kidney (HP:0000086)2.05737841
81Abnormality of the umbilical cord (HP:0010881)2.04690478
82Abnormal umbilical cord blood vessels (HP:0011403)2.03347953
83Single umbilical artery (HP:0001195)2.03347953
84Abnormality of the fetal cardiovascular system (HP:0010948)2.03347953
85Aplasia/Hypoplasia of the earlobes (HP:0009906)2.03258588
86Hyperacusis (HP:0010780)2.00694768
87Aplastic anemia (HP:0001915)1.99179013
88Pallor (HP:0000980)1.98996826
89Abnormality of abdominal situs (HP:0011620)1.97765321
90Abdominal situs inversus (HP:0003363)1.97765321
91Short thumb (HP:0009778)1.95963416
92Spastic diplegia (HP:0001264)1.95784807
93Progressive external ophthalmoplegia (HP:0000590)1.94968418
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.94303921
95Cellular immunodeficiency (HP:0005374)1.93428187
96Personality changes (HP:0000751)1.93225363
97Cafe-au-lait spot (HP:0000957)1.92612819
98Overlapping toe (HP:0001845)1.91423271
99Basal cell carcinoma (HP:0002671)1.91052206
100Insomnia (HP:0100785)1.89599361
101Abnormality of the astrocytes (HP:0100707)1.89533703
102Astrocytoma (HP:0009592)1.89533703
103Choanal atresia (HP:0000453)1.88942625
104Missing ribs (HP:0000921)1.88756965
105Duplication of thumb phalanx (HP:0009942)1.85972716
106Facial hemangioma (HP:0000329)1.85090204
107Hypoplastic pelvis (HP:0008839)1.82647512
108Squamous cell carcinoma (HP:0002860)1.82450806
109Glossoptosis (HP:0000162)1.82308922
110Shoulder girdle muscle weakness (HP:0003547)1.81918982
111Sparse eyelashes (HP:0000653)1.81899566
112Ulnar bowing (HP:0003031)1.81751767
113Abnormality of reticulocytes (HP:0004312)1.78864094
114Abnormalities of placenta or umbilical cord (HP:0001194)1.78767889
115Cleft eyelid (HP:0000625)1.78670849
116Abnormality of the carotid arteries (HP:0005344)1.78641099
117Spinal muscular atrophy (HP:0007269)1.78227710
118Oligodactyly (HP:0012165)1.77296335
119CNS hypomyelination (HP:0003429)1.76805397
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76615521
121Absent epiphyses (HP:0010577)1.76615521
122Entropion (HP:0000621)1.76562774
123Ragged-red muscle fibers (HP:0003200)1.76292955
124Abnormality of pyrimidine metabolism (HP:0004353)1.75642177
125Abnormality of the salivary glands (HP:0010286)1.75488758
126Type I transferrin isoform profile (HP:0003642)1.74501667
127Poikiloderma (HP:0001029)1.74470520
128Overriding aorta (HP:0002623)1.73838330
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.73778229
130Pelvic girdle muscle weakness (HP:0003749)1.73511678
131Breast aplasia (HP:0100783)1.73037423
132Reduced antithrombin III activity (HP:0001976)1.66319926
133Abnormality of the distal phalanges of the toes (HP:0010182)1.63596933
134Abnormality of the calcaneus (HP:0008364)1.62663956
135Embryonal neoplasm (HP:0002898)1.61242308
136Neoplasm of the colon (HP:0100273)1.60793267
137Pancytopenia (HP:0001876)1.60050617
138Small epiphyses (HP:0010585)1.58332424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.82018076
2* BUB13.72941555
3NEK23.69372561
4CDC73.59160751
5TTK3.11766065
6VRK23.08516887
7EIF2AK12.72362913
8EPHA22.59982244
9PLK42.59240410
10NEK12.58414808
11TSSK62.56906744
12SMG12.44660183
13PLK12.39615570
14TESK22.16419406
15BRSK22.14143067
16SRPK12.04861750
17AURKB1.88293379
18STK161.85433868
19TLK11.82445285
20DYRK31.79239676
21RPS6KB21.74582248
22PLK31.73946972
23AURKA1.70856253
24BRSK11.69688858
25CDK71.62045244
26MAP3K81.59914317
27CHEK21.59485056
28ACVR1B1.55379062
29EEF2K1.53079878
30STK101.52241441
31CDK121.49066931
32ATR1.48822219
33NME21.46647599
34CDK41.44786201
35MKNK11.42704278
36PAK41.38375944
37ZAK1.34843424
38RPS6KA41.34305360
39MAP3K101.33812197
40CHEK11.30405065
41VRK11.30168250
42PASK1.29057537
43TAF11.27567799
44MST1R1.27380788
45EIF2AK31.27330579
46MKNK21.16065857
47STK41.12227259
48PNCK1.07802989
49CCNB11.04019815
50ICK1.03250420
51MELK1.00409085
52LATS20.97355442
53PAK10.91885843
54SCYL20.91105007
55CDK20.89709336
56BRAF0.83715805
57TESK10.82308910
58ALK0.78094355
59STK30.77335324
60ATM0.77259205
61AKT30.76687353
62MET0.74616596
63CDK80.74227182
64CLK10.73722551
65PDK40.73098991
66PDK30.73098991
67KDR0.72702130
68MST40.72025300
69ARAF0.71818735
70PRKCI0.70603405
71MAPKAPK30.66270243
72* CDK10.66001289
73PIM10.62942991
74TGFBR10.61892953
75STK38L0.60579565
76CSNK2A20.58884329
77MTOR0.57319475
78TRIM280.56551757
79AKT20.56427674
80CSNK2A10.55863433
81ERBB40.55849095
82PKN20.55321076
83FGFR10.54176732
84BRD40.52801930
85PTK20.52273173
86CDK60.51277146
87LRRK20.50912504
88MAP3K110.50155765
89PBK0.47942246
90CDK90.47638837
91BCKDK0.46531586
92EIF2AK20.43384458
93LIMK10.43026978
94CSNK1E0.41777062
95PDK20.40497691
96FLT30.39801325
97TTN0.39021377
98IRAK30.35941211
99RPS6KA50.35315957
100BMX0.35232241
101DAPK10.35172263
102RAF10.34158328
103GRK60.30325519
104PIM20.29831906
105PRKDC0.29161113
106MAP3K90.28934949
107SIK10.27793295
108PAK20.26648804
109IRAK20.26221114
110CDK11A0.25752878
111DYRK20.24361284
112LATS10.23973587
113CDK150.23034264
114TRIB30.22694098
115TAOK20.22138685
116ILK0.21931502
117MAP2K20.21738933
118NME10.19618495
119CDK180.19508164
120MARK30.19278850
121CDK140.18321102

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.65504574
2Mismatch repair_Homo sapiens_hsa034303.92884712
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.88718587
4RNA transport_Homo sapiens_hsa030133.47261862
5Spliceosome_Homo sapiens_hsa030403.45665055
6RNA polymerase_Homo sapiens_hsa030203.30219821
7Proteasome_Homo sapiens_hsa030503.30052710
8Base excision repair_Homo sapiens_hsa034103.08839534
9* Cell cycle_Homo sapiens_hsa041103.03994319
10Ribosome_Homo sapiens_hsa030102.92345958
11Homologous recombination_Homo sapiens_hsa034402.78594774
12Nucleotide excision repair_Homo sapiens_hsa034202.73159229
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62846171
14One carbon pool by folate_Homo sapiens_hsa006702.48923621
15Pyrimidine metabolism_Homo sapiens_hsa002402.40489087
16Vitamin B6 metabolism_Homo sapiens_hsa007502.27633113
17Fanconi anemia pathway_Homo sapiens_hsa034602.23524512
18p53 signaling pathway_Homo sapiens_hsa041151.94311896
19Basal transcription factors_Homo sapiens_hsa030221.93904507
20mRNA surveillance pathway_Homo sapiens_hsa030151.82573186
21RNA degradation_Homo sapiens_hsa030181.75463284
22Non-homologous end-joining_Homo sapiens_hsa034501.64946081
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32570484
24* Oocyte meiosis_Homo sapiens_hsa041141.31260629
25Purine metabolism_Homo sapiens_hsa002301.28785768
26Epstein-Barr virus infection_Homo sapiens_hsa051691.23146035
27Pyruvate metabolism_Homo sapiens_hsa006201.20924438
28Systemic lupus erythematosus_Homo sapiens_hsa053221.18916408
29Folate biosynthesis_Homo sapiens_hsa007901.14947825
30Pentose phosphate pathway_Homo sapiens_hsa000301.14620916
31Biosynthesis of amino acids_Homo sapiens_hsa012301.13638350
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10952675
33* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10787616
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.09391170
35Fatty acid elongation_Homo sapiens_hsa000621.03098382
36Parkinsons disease_Homo sapiens_hsa050120.99885253
37Selenocompound metabolism_Homo sapiens_hsa004500.97614479
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95719924
39* Viral carcinogenesis_Homo sapiens_hsa052030.92200632
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.83918755
41Basal cell carcinoma_Homo sapiens_hsa052170.79369318
42Oxidative phosphorylation_Homo sapiens_hsa001900.78997271
43MicroRNAs in cancer_Homo sapiens_hsa052060.76942297
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76709810
45Hedgehog signaling pathway_Homo sapiens_hsa043400.76109863
46* HTLV-I infection_Homo sapiens_hsa051660.73236747
47Antigen processing and presentation_Homo sapiens_hsa046120.72713452
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72154378
49Hippo signaling pathway_Homo sapiens_hsa043900.71914918
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.69533976
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68694752
52Herpes simplex infection_Homo sapiens_hsa051680.65910880
53Sulfur relay system_Homo sapiens_hsa041220.65387369
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65251029
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64916978
56Notch signaling pathway_Homo sapiens_hsa043300.64383944
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63139439
58Carbon metabolism_Homo sapiens_hsa012000.63074467
59Bladder cancer_Homo sapiens_hsa052190.62270191
60Small cell lung cancer_Homo sapiens_hsa052220.60616735
61Steroid biosynthesis_Homo sapiens_hsa001000.60544287
62Lysine degradation_Homo sapiens_hsa003100.58031009
63Fructose and mannose metabolism_Homo sapiens_hsa000510.57283642
64Glutathione metabolism_Homo sapiens_hsa004800.55793305
65Thyroid cancer_Homo sapiens_hsa052160.52253513
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51210303
67Protein export_Homo sapiens_hsa030600.50697908
68Alzheimers disease_Homo sapiens_hsa050100.48326429
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47457003
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.42083026
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41604691
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41441854
73Apoptosis_Homo sapiens_hsa042100.41214754
74TGF-beta signaling pathway_Homo sapiens_hsa043500.41158012
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39848392
76Regulation of autophagy_Homo sapiens_hsa041400.37044363
77Alcoholism_Homo sapiens_hsa050340.36177531
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35785611
79Colorectal cancer_Homo sapiens_hsa052100.34768312
80Legionellosis_Homo sapiens_hsa051340.34701539
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33184011
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32002951
83Pancreatic cancer_Homo sapiens_hsa052120.31883151
84mTOR signaling pathway_Homo sapiens_hsa041500.31036415
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30004163
86Huntingtons disease_Homo sapiens_hsa050160.29475214
87Pathways in cancer_Homo sapiens_hsa052000.27882599
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27698820
89HIF-1 signaling pathway_Homo sapiens_hsa040660.26714273
90Arginine biosynthesis_Homo sapiens_hsa002200.25729474
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25696359
92Tight junction_Homo sapiens_hsa045300.24949602
93Non-small cell lung cancer_Homo sapiens_hsa052230.23735196
94Shigellosis_Homo sapiens_hsa051310.23451208
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21852631
96Galactose metabolism_Homo sapiens_hsa000520.21707430
97N-Glycan biosynthesis_Homo sapiens_hsa005100.21369184
98Chronic myeloid leukemia_Homo sapiens_hsa052200.20723546
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.20508519
100Hepatitis B_Homo sapiens_hsa051610.19406317
101Arginine and proline metabolism_Homo sapiens_hsa003300.19362248
102Metabolic pathways_Homo sapiens_hsa011000.19245144
103Vitamin digestion and absorption_Homo sapiens_hsa049770.19150181
104Sulfur metabolism_Homo sapiens_hsa009200.18967603
105Phenylalanine metabolism_Homo sapiens_hsa003600.18908090
106Adherens junction_Homo sapiens_hsa045200.18785430
107Renin-angiotensin system_Homo sapiens_hsa046140.17323579
108Fatty acid metabolism_Homo sapiens_hsa012120.17031146
109Wnt signaling pathway_Homo sapiens_hsa043100.14678359
110FoxO signaling pathway_Homo sapiens_hsa040680.13525987
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12101205
112Prostate cancer_Homo sapiens_hsa052150.10322593
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10203955
114Proteoglycans in cancer_Homo sapiens_hsa052050.08464867
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07253226
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04176162
117AMPK signaling pathway_Homo sapiens_hsa041520.02720410
118Melanoma_Homo sapiens_hsa052180.02495715
119Acute myeloid leukemia_Homo sapiens_hsa052210.02158926
120Primary immunodeficiency_Homo sapiens_hsa053400.01944049

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