CDC20B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.78667005
2epithelial cilium movement (GO:0003351)9.77406714
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.50140228
4sperm motility (GO:0030317)9.31447412
5cilium movement (GO:0003341)8.64347344
6acrosome reaction (GO:0007340)8.36649512
7fusion of sperm to egg plasma membrane (GO:0007342)7.91469129
8sperm-egg recognition (GO:0035036)7.83179971
9cell wall macromolecule catabolic process (GO:0016998)7.79757265
10cell wall macromolecule metabolic process (GO:0044036)7.79757265
11acrosome assembly (GO:0001675)7.33760398
12binding of sperm to zona pellucida (GO:0007339)7.32145352
13male meiosis I (GO:0007141)7.19328560
14regulation of cilium movement (GO:0003352)7.15215818
15cell-cell recognition (GO:0009988)7.12560440
16spermatid development (GO:0007286)6.77771432
17multicellular organism reproduction (GO:0032504)6.41922546
18meiosis I (GO:0007127)6.19819536
19centriole replication (GO:0007099)6.00247476
20plasma membrane fusion (GO:0045026)5.81217624
21reproduction (GO:0000003)5.70178600
22male meiosis (GO:0007140)5.51971763
23synaptonemal complex organization (GO:0070193)5.32976941
24interferon-gamma production (GO:0032609)5.31848025
25cytolysis (GO:0019835)5.25307049
26glucocorticoid receptor signaling pathway (GO:0042921)5.16288758
27piRNA metabolic process (GO:0034587)5.16035344
28spermatogenesis (GO:0007283)5.09930558
29male gamete generation (GO:0048232)5.08163150
30synaptonemal complex assembly (GO:0007130)5.06215596
31negative regulation of inclusion body assembly (GO:0090084)5.04728562
32L-fucose catabolic process (GO:0042355)4.74408756
33fucose catabolic process (GO:0019317)4.74408756
34L-fucose metabolic process (GO:0042354)4.74408756
35behavioral response to nicotine (GO:0035095)4.67966815
36gamete generation (GO:0007276)4.67317108
37chromosome condensation (GO:0030261)4.65928259
38base-excision repair, AP site formation (GO:0006285)4.58860174
39single fertilization (GO:0007338)4.50258367
40DNA packaging (GO:0006323)4.47271254
41meiotic nuclear division (GO:0007126)4.40025136
42microtubule depolymerization (GO:0007019)4.39124286
43sperm capacitation (GO:0048240)4.33309098
44activated T cell proliferation (GO:0050798)4.25295728
45protein refolding (GO:0042026)4.23999120
46regulation of microtubule-based movement (GO:0060632)4.13311064
47spermatid nucleus differentiation (GO:0007289)4.12250249
48intraciliary transport (GO:0042073)4.09729930
49corticosteroid receptor signaling pathway (GO:0031958)4.09306210
50sequestering of actin monomers (GO:0042989)4.08989622
51GTP biosynthetic process (GO:0006183)4.05343013
52left/right pattern formation (GO:0060972)4.02745057
53axoneme assembly (GO:0035082)4.02132536
54protein polyglutamylation (GO:0018095)3.97697464
55organic cation transport (GO:0015695)3.95267289
56fertilization (GO:0009566)3.95241429
57ventricular system development (GO:0021591)3.83519427
58cilium organization (GO:0044782)3.82721779
59cilium assembly (GO:0042384)3.81772364
60germ cell development (GO:0007281)3.76300007
61microtubule severing (GO:0051013)3.75484124
62UTP biosynthetic process (GO:0006228)3.72739709
63regulation of inclusion body assembly (GO:0090083)3.71012290
64neural tube formation (GO:0001841)3.67661911
65response to pheromone (GO:0019236)3.67400287
66chromosome organization involved in meiosis (GO:0070192)3.64104239
67multicellular organismal reproductive process (GO:0048609)3.63241301
68cellular process involved in reproduction in multicellular organism (GO:0022412)3.60191162
69cellular response to interleukin-15 (GO:0071350)3.56719460
70calcium ion-dependent exocytosis (GO:0017156)3.55951094
71cilium morphogenesis (GO:0060271)3.55462947
72nonmotile primary cilium assembly (GO:0035058)3.54752815
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53961667
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53559425
75seminiferous tubule development (GO:0072520)3.52436628
76nucleoside diphosphate phosphorylation (GO:0006165)3.51406685
77protein localization to cilium (GO:0061512)3.50650284
78regulation of DNA endoreduplication (GO:0032875)3.47314030
79UTP metabolic process (GO:0046051)3.43039313
80regulation of centriole replication (GO:0046599)3.42816015
81photoreceptor cell maintenance (GO:0045494)3.37980067
82CTP biosynthetic process (GO:0006241)3.36562809
83CTP metabolic process (GO:0046036)3.36562809
84cell recognition (GO:0008037)3.27121283
85RNA-dependent DNA replication (GO:0006278)3.26491342
86indole-containing compound catabolic process (GO:0042436)3.25144341
87indolalkylamine catabolic process (GO:0046218)3.25144341
88tryptophan catabolic process (GO:0006569)3.25144341
89DNA methylation involved in gamete generation (GO:0043046)3.24111964
90cellular component assembly involved in morphogenesis (GO:0010927)3.22690529
91meiotic cell cycle (GO:0051321)3.22684250
92DNA deamination (GO:0045006)3.20954873
93indolalkylamine metabolic process (GO:0006586)3.20945594
94sexual reproduction (GO:0019953)3.19074791
95pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17239067
96meiotic cell cycle process (GO:1903046)3.17134006
97regulation of chromatin binding (GO:0035561)3.15019199
98kynurenine metabolic process (GO:0070189)3.12853867
99detection of light stimulus involved in sensory perception (GO:0050962)3.12282888
100detection of light stimulus involved in visual perception (GO:0050908)3.12282888
101negative T cell selection (GO:0043383)3.09914002
102regulation of natural killer cell mediated immunity (GO:0002715)3.06878237
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06878237
104negative thymic T cell selection (GO:0045060)3.06875397
105microtubule bundle formation (GO:0001578)3.05688823
106microtubule-based movement (GO:0007018)3.02931334
107chaperone-mediated protein complex assembly (GO:0051131)3.00702387
108pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.98432560
109cellular ketone body metabolic process (GO:0046950)2.97783866
110cornea development in camera-type eye (GO:0061303)2.97163122
111pyrimidine nucleotide catabolic process (GO:0006244)2.95405307
112polyketide metabolic process (GO:0030638)2.95190595
113doxorubicin metabolic process (GO:0044598)2.95190595
114daunorubicin metabolic process (GO:0044597)2.95190595
115negative regulation of mast cell activation (GO:0033004)2.94916522
116gamma-aminobutyric acid transport (GO:0015812)2.91329356
117guanosine-containing compound biosynthetic process (GO:1901070)2.89120300
118respiratory chain complex IV assembly (GO:0008535)2.88655290
119glycerol ether metabolic process (GO:0006662)2.83991476
120L-methionine salvage (GO:0071267)2.83845537
121L-methionine biosynthetic process (GO:0071265)2.83845537
122amino acid salvage (GO:0043102)2.83845537
123S-adenosylmethionine metabolic process (GO:0046500)2.83568917
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82237224
125preassembly of GPI anchor in ER membrane (GO:0016254)2.82224031
126response to interleukin-15 (GO:0070672)2.81486248
127left/right axis specification (GO:0070986)2.81120507
128protein K11-linked deubiquitination (GO:0035871)2.80254073
129negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.79402201
130platelet dense granule organization (GO:0060155)2.79209943
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78070683
132negative regulation of cell killing (GO:0031342)2.78070683
133protein complex biogenesis (GO:0070271)2.74508434
134tryptophan metabolic process (GO:0006568)2.74044670
135retinal cone cell development (GO:0046549)2.69769745
136ketone body metabolic process (GO:1902224)2.69663284
137pyrimidine nucleobase catabolic process (GO:0006208)2.68719694
138sulfation (GO:0051923)2.66135149
139water-soluble vitamin biosynthetic process (GO:0042364)2.65737890
140amine catabolic process (GO:0009310)2.65105657
141cellular biogenic amine catabolic process (GO:0042402)2.65105657
142cell projection assembly (GO:0030031)2.63436416
143cytochrome complex assembly (GO:0017004)2.63362384
144negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62964276
145inner ear receptor stereocilium organization (GO:0060122)2.61826753
146neuronal action potential (GO:0019228)2.61551800
147transmission of nerve impulse (GO:0019226)2.61457891
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.60464814
149NADH dehydrogenase complex assembly (GO:0010257)2.60464814
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60464814
151regulation of action potential (GO:0098900)2.57845402
152rhodopsin mediated signaling pathway (GO:0016056)2.57607335
153photoreceptor cell development (GO:0042461)2.57509432
154behavioral response to ethanol (GO:0048149)2.57373488
155mannosylation (GO:0097502)2.57264104
156auditory receptor cell stereocilium organization (GO:0060088)2.55299610
157reflex (GO:0060004)2.54348130
158negative regulation of telomere maintenance (GO:0032205)2.54186711
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54173408
160smoothened signaling pathway (GO:0007224)2.53988821
161regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49865509
162mitochondrial respiratory chain complex assembly (GO:0033108)2.46334389
163dopamine transport (GO:0015872)2.45201491
164determination of left/right symmetry (GO:0007368)2.44035860
165microtubule polymerization or depolymerization (GO:0031109)2.43197464
166drug catabolic process (GO:0042737)2.40157712
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.39393138
168rRNA catabolic process (GO:0016075)2.39129741
169embryonic epithelial tube formation (GO:0001838)2.38747568
170exogenous drug catabolic process (GO:0042738)2.37758627
171regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36955598
172motile cilium assembly (GO:0044458)13.3780222
173centriole assembly (GO:0098534)12.2126324
174axonemal dynein complex assembly (GO:0070286)11.5459676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.58642243
2EZH2_22144423_ChIP-Seq_EOC_Human3.64231751
3GATA1_26923725_Chip-Seq_HPCs_Mouse3.38802421
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15037653
5GBX2_23144817_ChIP-Seq_PC3_Human2.88917050
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.85288678
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85172719
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64862140
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.57869404
10IGF1R_20145208_ChIP-Seq_DFB_Human2.54147842
11ELK4_26923725_Chip-Seq_MESODERM_Mouse2.48855032
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35997213
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.35027173
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29800767
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26514170
16TAF15_26573619_Chip-Seq_HEK293_Human2.25916342
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22884134
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10795847
19FUS_26573619_Chip-Seq_HEK293_Human2.06023804
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05523828
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97648510
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.96961424
23EWS_26573619_Chip-Seq_HEK293_Human1.96406902
24P300_19829295_ChIP-Seq_ESCs_Human1.93392543
25MYB_26560356_Chip-Seq_TH2_Human1.91537743
26ER_23166858_ChIP-Seq_MCF-7_Human1.87499726
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81552851
28SOX2_22085726_ChIP-Seq_NPCs_Mouse1.76804241
29SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.70549128
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68990488
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67747224
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64601334
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60642821
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.60441290
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.59102728
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.56496718
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55486285
38BCAT_22108803_ChIP-Seq_LS180_Human1.54460499
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52191931
40VDR_22108803_ChIP-Seq_LS180_Human1.51791386
41SMAD4_21799915_ChIP-Seq_A2780_Human1.51145549
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49742518
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49052932
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.48964914
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48691632
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.48665467
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48238172
48AR_25329375_ChIP-Seq_VCAP_Human1.47552825
49MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46860236
50STAT3_23295773_ChIP-Seq_U87_Human1.46821223
51TP53_22573176_ChIP-Seq_HFKS_Human1.46419627
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45961479
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45363834
54RUNX_20019798_ChIP-Seq_JUKART_Human1.43196508
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42462976
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42077815
57* TCF4_23295773_ChIP-Seq_U87_Human1.40757087
58MYB_26560356_Chip-Seq_TH1_Human1.39392223
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39349828
60GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38554082
61IRF1_19129219_ChIP-ChIP_H3396_Human1.38304009
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37638945
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37242511
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36540126
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36449494
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36021006
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35910490
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34575891
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.34575891
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33047723
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.33047171
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32792431
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31727383
74TCF4_22108803_ChIP-Seq_LS180_Human1.30896765
75SOX2_19829295_ChIP-Seq_ESCs_Human1.30463859
76NANOG_19829295_ChIP-Seq_ESCs_Human1.30463859
77MAF_26560356_Chip-Seq_TH1_Human1.29667562
78CBP_20019798_ChIP-Seq_JUKART_Human1.28618712
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28618712
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27834892
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26833137
82MYC_18940864_ChIP-ChIP_HL60_Human1.26584710
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.26521505
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26466963
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.25808977
86GATA3_27048872_Chip-Seq_THYMUS_Human1.25733707
87ZNF274_21170338_ChIP-Seq_K562_Hela1.25504139
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25152385
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25133378
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24675927
91NCOR_22424771_ChIP-Seq_293T_Human1.24574743
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.22517963
93RUNX2_22187159_ChIP-Seq_PCA_Human1.22149664
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22004338
95RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20845083
96FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20690256
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.20646503
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.18876240
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18771134
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17965517
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17321040
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16856655
103STAT1_17558387_ChIP-Seq_HELA_Human1.15068819
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.14988220
105GF1_26923725_Chip-Seq_HPCs_Mouse1.13225771
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.11963091
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.11499574
108HOXB7_26014856_ChIP-Seq_BT474_Human1.10105761
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09867891
110ERG_20517297_ChIP-Seq_VCAP_Human1.09612208
111AR_20517297_ChIP-Seq_VCAP_Human1.09559512
112GATA3_21867929_ChIP-Seq_CD8_Mouse1.09206075
113FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08613739
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07710786
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06725039
116CTCF_20526341_ChIP-Seq_ESCs_Human1.06690313
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.06671482
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.05615492
119FLI1_21867929_ChIP-Seq_CD8_Mouse1.05580668
120KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05432357
121MYC_19829295_ChIP-Seq_ESCs_Human1.05238257
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04975805
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04682047
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04312728
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03297896
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.03116164
127AR_21572438_ChIP-Seq_LNCaP_Human1.02984110
128SMC4_20622854_ChIP-Seq_HELA_Human1.02561588
129P53_22387025_ChIP-Seq_ESCs_Mouse1.01775797
130EGR1_19374776_ChIP-ChIP_THP-1_Human1.01718382
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01224895
132ESET_19884257_ChIP-Seq_ESCs_Mouse1.00832714
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00758338
134ETS1_21867929_ChIP-Seq_TH2_Mouse1.00695280
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00261603
136DROSHA_22980978_ChIP-Seq_HELA_Human0.99537573
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.99492576
138TCF7_22412390_ChIP-Seq_EML_Mouse0.99469717
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98059581
140CDX2_22108803_ChIP-Seq_LS180_Human0.97800623
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97193056
142RNF2_27304074_Chip-Seq_NSC_Mouse0.96825167
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96384804
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96325013
145FOXH1_21741376_ChIP-Seq_EPCs_Human0.94811363
146NANOG_20526341_ChIP-Seq_ESCs_Human0.94709726
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.94447270
148* P53_21459846_ChIP-Seq_SAOS-2_Human0.93048095
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.91834347
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.91830079
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90885093
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90479851
153UTX_26944678_Chip-Seq_JUKART_Human0.90086953
154MAF_26560356_Chip-Seq_TH2_Human0.89757295
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89728657
156AR_21909140_ChIP-Seq_LNCAP_Human0.89446192
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88223455
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86890956
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86538974
160RUNX1_27514584_Chip-Seq_MCF-7_Human0.86406635
161KDM2B_26808549_Chip-Seq_REH_Human0.86086812
162REST_21632747_ChIP-Seq_MESCs_Mouse0.85123701
163GATA3_21867929_ChIP-Seq_TH1_Mouse0.85002473
164MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84962949
165OCT1_27270436_Chip-Seq_PROSTATE_Human0.84464020
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83993760
167SOX2_21211035_ChIP-Seq_LN229_Human0.83805629
168CTCF_26484167_Chip-Seq_Bcells_Mouse0.83388418
169MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82814319
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82625188
171TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82625188
172GATA3_26560356_Chip-Seq_TH1_Human0.82549563
173MYC_27129775_Chip-Seq_CORNEA_Mouse0.82267946
174TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80382055
175CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79553567
176NFYB_21822215_ChIP-Seq_K562_Human0.79091355
177FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78448005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.52414204
2MP0001929_abnormal_gametogenesis4.30624279
3MP0006082_CNS_inflammation3.51236930
4MP0008877_abnormal_DNA_methylation3.46957516
5MP0005671_abnormal_response_to3.39534487
6MP0002210_abnormal_sex_determination2.94331633
7MP0005551_abnormal_eye_electrophysiolog2.47541016
8MP0002161_abnormal_fertility/fecundity2.43921973
9MP0001145_abnormal_male_reproductive2.42803432
10MP0002102_abnormal_ear_morphology2.39829684
11MP0003763_abnormal_thymus_physiology2.30487090
12MP0005397_hematopoietic_system_phenotyp2.28556669
13MP0001545_abnormal_hematopoietic_system2.28556669
14MP0008875_abnormal_xenobiotic_pharmacok2.21264468
15MP0004808_abnormal_hematopoietic_stem2.20488839
16MP0000569_abnormal_digit_pigmentation2.18959836
17MP0006292_abnormal_olfactory_placode2.17482758
18MP0005645_abnormal_hypothalamus_physiol2.12730023
19MP0003880_abnormal_central_pattern2.07816502
20MP0003195_calcinosis2.06675572
21MP0002132_abnormal_respiratory_system2.04918230
22MP0004782_abnormal_surfactant_physiolog2.04895317
23MP0001968_abnormal_touch/_nociception2.04782274
24MP0000653_abnormal_sex_gland2.02577129
25MP0005410_abnormal_fertilization10.9483090
26MP0002876_abnormal_thyroid_physiology1.97564362
27MP0003448_altered_tumor_morphology1.90752813
28MP0009046_muscle_twitch1.89617715
29MP0009745_abnormal_behavioral_response1.85680375
30MP0008872_abnormal_physiological_respon1.83424590
31MP0002837_dystrophic_cardiac_calcinosis1.81478058
32MP0003136_yellow_coat_color1.76966410
33MP0000537_abnormal_urethra_morphology1.75648500
34MP0002234_abnormal_pharynx_morphology1.74744544
35MP0006276_abnormal_autonomic_nervous1.72157177
36MP0005646_abnormal_pituitary_gland1.70588282
37MP0004142_abnormal_muscle_tone1.69891235
38MP0010307_abnormal_tumor_latency1.69769283
39MP0002638_abnormal_pupillary_reflex1.63625064
40MP0002938_white_spotting1.63236619
41MP0000372_irregular_coat_pigmentation1.62857794
42MP0004885_abnormal_endolymph1.60865012
43MP0002272_abnormal_nervous_system1.59831597
44MP0002736_abnormal_nociception_after1.57434325
45MP0005623_abnormal_meninges_morphology1.57247028
46MP0002160_abnormal_reproductive_system1.56484188
47MP0001485_abnormal_pinna_reflex1.56354193
48MP0004043_abnormal_pH_regulation1.55799713
49MP0003115_abnormal_respiratory_system1.52760539
50MP0001486_abnormal_startle_reflex1.51301706
51MP0000631_abnormal_neuroendocrine_gland1.51261879
52MP0001986_abnormal_taste_sensitivity1.50331480
53MP0003011_delayed_dark_adaptation1.48811834
54MP0003123_paternal_imprinting1.47441524
55MP0003077_abnormal_cell_cycle1.44380139
56MP0000858_altered_metastatic_potential1.39230279
57MP0001501_abnormal_sleep_pattern1.38677951
58MP0000427_abnormal_hair_cycle1.37410742
59MP0000566_synostosis1.37079912
60MP0006072_abnormal_retinal_apoptosis1.36805589
61MP0002796_impaired_skin_barrier1.36435660
62MP0008057_abnormal_DNA_replication1.35653481
63MP0005084_abnormal_gallbladder_morpholo1.34382702
64MP0002557_abnormal_social/conspecific_i1.32883626
65MP0002127_abnormal_cardiovascular_syste1.32352157
66MP0002282_abnormal_trachea_morphology1.28217840
67MP0001970_abnormal_pain_threshold1.27165861
68MP0004147_increased_porphyrin_level1.26393288
69MP0002138_abnormal_hepatobiliary_system1.24727585
70MP0002572_abnormal_emotion/affect_behav1.22263087
71MP0002653_abnormal_ependyma_morphology1.21863508
72MP0002064_seizures1.21112724
73MP0004742_abnormal_vestibular_system1.19912543
74MP0002735_abnormal_chemical_nociception1.17274001
75MP0001905_abnormal_dopamine_level1.15866855
76MP0003941_abnormal_skin_development1.15457101
77MP0000703_abnormal_thymus_morphology1.12979118
78MP0003718_maternal_effect1.12313407
79MP0000026_abnormal_inner_ear1.12113194
80MP0002734_abnormal_mechanical_nocicepti1.10959780
81MP0003878_abnormal_ear_physiology1.10881874
82MP0005377_hearing/vestibular/ear_phenot1.10881874
83MP0002405_respiratory_system_inflammati1.09908846
84MP0002398_abnormal_bone_marrow1.09664237
85MP0005670_abnormal_white_adipose1.08483229
86MP0005367_renal/urinary_system_phenotyp1.08001553
87MP0000516_abnormal_urinary_system1.08001553
88MP0001873_stomach_inflammation1.06079305
89MP0003787_abnormal_imprinting1.05803004
90MP0002733_abnormal_thermal_nociception1.05487275
91MP0003693_abnormal_embryo_hatching1.05306928
92MP0004197_abnormal_fetal_growth/weight/1.04541071
93MP0005174_abnormal_tail_pigmentation1.04313238
94MP0008058_abnormal_DNA_repair1.03516745
95MP0005195_abnormal_posterior_eye1.02892159
96MP0004924_abnormal_behavior1.02441547
97MP0005386_behavior/neurological_phenoty1.02441547
98MP0001919_abnormal_reproductive_system1.02308460
99MP0002752_abnormal_somatic_nervous1.01161261
100MP0002067_abnormal_sensory_capabilities1.00033291
101MP0003122_maternal_imprinting0.99384042
102MP0003950_abnormal_plasma_membrane0.98411407
103MP0000490_abnormal_crypts_of0.97492493
104MP0001730_embryonic_growth_arrest0.97343956
105MP0002420_abnormal_adaptive_immunity0.97290050
106MP0000778_abnormal_nervous_system0.95219919
107MP0003635_abnormal_synaptic_transmissio0.93707086
108MP0008007_abnormal_cellular_replicative0.93672133
109MP0005423_abnormal_somatic_nervous0.93639657
110MP0001819_abnormal_immune_cell0.93586247
111MP0000383_abnormal_hair_follicle0.93234957
112MP0010386_abnormal_urinary_bladder0.93208818
113MP0005085_abnormal_gallbladder_physiolo0.92465647
114MP0001963_abnormal_hearing_physiology0.92447734
115MP0001293_anophthalmia0.90669608
116MP0010094_abnormal_chromosome_stability0.89585098
117MP0005379_endocrine/exocrine_gland_phen0.88989369
118MP0002063_abnormal_learning/memory/cond0.87767734
119MP0002909_abnormal_adrenal_gland0.87636920
120MP0002163_abnormal_gland_morphology0.87209140
121MP0003121_genomic_imprinting0.85745274
122MP0008995_early_reproductive_senescence0.85567048
123MP0005025_abnormal_response_to0.84885049
124MP0008789_abnormal_olfactory_epithelium0.84256181
125MP0005389_reproductive_system_phenotype0.82298219
126MP0002751_abnormal_autonomic_nervous0.81329840
127MP0003943_abnormal_hepatobiliary_system0.81323870
128MP0000716_abnormal_immune_system0.79283784
129MP0002229_neurodegeneration0.78804805
130MP0003567_abnormal_fetal_cardiomyocyte0.78718357
131MP0001502_abnormal_circadian_rhythm0.78225859
132MP0003938_abnormal_ear_development0.77735013
133MP0001800_abnormal_humoral_immune0.77539379
134MP0001849_ear_inflammation0.75493987
135MP0003119_abnormal_digestive_system0.75282126
136MP0005253_abnormal_eye_physiology0.74364067
137MP0000350_abnormal_cell_proliferation0.74082250
138MP0003942_abnormal_urinary_system0.72793989
139MP0000685_abnormal_immune_system0.69720651
140MP0001984_abnormal_olfaction0.68853879
141MP0009053_abnormal_anal_canal0.68715230
142MP0005083_abnormal_biliary_tract0.68696574
143MP0002722_abnormal_immune_system0.66811605
144MP0000613_abnormal_salivary_gland0.66139986
145MP0003646_muscle_fatigue0.65770105
146MP0005076_abnormal_cell_differentiation0.65086971
147MP0004957_abnormal_blastocyst_morpholog0.64688851
148MP0001529_abnormal_vocalization0.64421570
149MP0003221_abnormal_cardiomyocyte_apopto0.64092667
150MP0002723_abnormal_immune_serum0.63856338
151MP0009333_abnormal_splenocyte_physiolog0.61325504
152MP0005394_taste/olfaction_phenotype0.61099460
153MP0005499_abnormal_olfactory_system0.61099460
154MP0002429_abnormal_blood_cell0.60644014
155MP0000534_abnormal_ureter_morphology0.60292629
156MP0010352_gastrointestinal_tract_polyps0.58375023
157MP0005408_hypopigmentation0.57864635
158MP0002086_abnormal_extraembryonic_tissu0.57323271
159MP0002019_abnormal_tumor_incidence0.56794029
160MP0003861_abnormal_nervous_system0.56476175
161MP0002084_abnormal_developmental_patter0.56149636
162MP0001915_intracranial_hemorrhage0.54917381
163MP0004272_abnormal_basement_membrane0.54564190
164MP0002928_abnormal_bile_duct0.54159981
165MP0002233_abnormal_nose_morphology0.53552692
166MP0000689_abnormal_spleen_morphology0.53386230
167MP0005391_vision/eye_phenotype0.52690639
168MP0004133_heterotaxia0.52593374
169MP0001286_abnormal_eye_development0.51556702
170MP0009785_altered_susceptibility_to0.50589299
171MP0002697_abnormal_eye_size0.49985675
172MP0003111_abnormal_nucleus_morphology0.49621146

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.30982136
2Abnormal respiratory motile cilium morphology (HP:0005938)8.33606027
3Abnormal respiratory epithelium morphology (HP:0012253)8.33606027
4Abnormal ciliary motility (HP:0012262)7.78414628
5Rhinitis (HP:0012384)7.74444380
6Nasal polyposis (HP:0100582)7.31807292
7Chronic bronchitis (HP:0004469)6.57244357
8Abnormality of the nasal mucosa (HP:0000433)5.86678534
9Infertility (HP:0000789)5.63548305
10Bronchiectasis (HP:0002110)5.61720582
11Bronchitis (HP:0012387)3.92334718
12Chronic hepatic failure (HP:0100626)3.72944330
13Supernumerary spleens (HP:0009799)3.72565495
14Nephronophthisis (HP:0000090)3.64779196
15Chronic sinusitis (HP:0011109)3.58367173
16Tubulointerstitial nephritis (HP:0001970)3.31017049
17Recurrent otitis media (HP:0000403)3.15811463
18Type II lissencephaly (HP:0007260)3.11403879
19Congenital stationary night blindness (HP:0007642)3.10715529
20Abnormality of the renal medulla (HP:0100957)2.80579241
21Abnormal drinking behavior (HP:0030082)2.77230171
22Polydipsia (HP:0001959)2.77230171
23Abnormal rod and cone electroretinograms (HP:0008323)2.71926228
24Attenuation of retinal blood vessels (HP:0007843)2.71667322
25Hyperventilation (HP:0002883)2.67813913
26Medial flaring of the eyebrow (HP:0010747)2.66380082
27Bile duct proliferation (HP:0001408)2.50828515
28Abnormal biliary tract physiology (HP:0012439)2.50828515
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47766255
30Abolished electroretinogram (ERG) (HP:0000550)2.47316349
31Furrowed tongue (HP:0000221)2.46221929
32Decreased central vision (HP:0007663)2.45285925
33Tetraplegia (HP:0002445)2.44340281
34Increased CSF protein (HP:0002922)2.44145420
35Male infertility (HP:0003251)2.41786391
36Pancreatic fibrosis (HP:0100732)2.38190312
37Male pseudohermaphroditism (HP:0000037)2.37680219
38Tubulointerstitial abnormality (HP:0001969)2.37047075
39Hemiplegia (HP:0002301)2.31571047
40Facial cleft (HP:0002006)2.29076683
41Hypoproteinemia (HP:0003075)2.27908771
42Occipital encephalocele (HP:0002085)2.25089780
43Pendular nystagmus (HP:0012043)2.22627321
44Postaxial foot polydactyly (HP:0001830)2.20691157
45Recurrent bronchitis (HP:0002837)2.15728292
46Menstrual irregularities (HP:0000858)2.14360808
47Polyuria (HP:0000103)2.14016602
48Keratoconus (HP:0000563)2.13871468
49Increased corneal curvature (HP:0100692)2.13871468
50Heterotopia (HP:0002282)2.12272425
51Bony spicule pigmentary retinopathy (HP:0007737)2.11619288
52Median cleft lip (HP:0000161)2.09733128
53True hermaphroditism (HP:0010459)2.08852630
54Gait imbalance (HP:0002141)2.08185583
55Absent speech (HP:0001344)2.06889849
56Cerebellar dysplasia (HP:0007033)2.06799873
57Abnormality of midbrain morphology (HP:0002418)2.06290194
58Molar tooth sign on MRI (HP:0002419)2.06290194
59Tubular atrophy (HP:0000092)2.05107581
60Tubulointerstitial fibrosis (HP:0005576)2.04880571
61Abnormal spermatogenesis (HP:0008669)2.04168016
62Congenital primary aphakia (HP:0007707)2.02092631
63Anencephaly (HP:0002323)2.01907842
64Progressive cerebellar ataxia (HP:0002073)2.01338967
65Abnormality of dentin (HP:0010299)2.00770508
66Dynein arm defect of respiratory motile cilia (HP:0012255)11.2669126
67Absent/shortened dynein arms (HP:0200106)11.2669126
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6526474
69Gaze-evoked nystagmus (HP:0000640)1.99262540
70Stomach cancer (HP:0012126)1.97501758
71Short 4th metacarpal (HP:0010044)1.94707542
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94707542
73Nephrogenic diabetes insipidus (HP:0009806)1.90052176
74T lymphocytopenia (HP:0005403)1.88244645
75Truncal obesity (HP:0001956)1.87852868
76Retinal dysplasia (HP:0007973)1.87241006
77Lissencephaly (HP:0001339)1.86249743
78Optic nerve hypoplasia (HP:0000609)1.81490398
79Retinitis pigmentosa (HP:0000510)1.81348828
80Decreased circulating renin level (HP:0003351)1.80963147
81Inability to walk (HP:0002540)1.80733355
82Vaginal atresia (HP:0000148)1.80541693
83Congenital hepatic fibrosis (HP:0002612)1.79900757
84Recurrent sinusitis (HP:0011108)1.79663584
85Abnormality of T cell number (HP:0011839)1.78199379
86Papillary thyroid carcinoma (HP:0002895)1.78190705
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.78033643
88Renal cortical cysts (HP:0000803)1.77800306
89Double outlet right ventricle (HP:0001719)1.77036706
90Congenital malformation of the right heart (HP:0011723)1.77036706
91Abnormality of macular pigmentation (HP:0008002)1.75540577
92Absent eyebrow (HP:0002223)1.75382998
93Narrow forehead (HP:0000341)1.74934231
94Decreased testicular size (HP:0008734)1.74833560
95Large for gestational age (HP:0001520)1.74753406
96Genital tract atresia (HP:0001827)1.74749014
97Genetic anticipation (HP:0003743)1.74235266
98Pancreatic cysts (HP:0001737)1.73962370
99Abnormality of the labia minora (HP:0012880)1.73812823
100Abnormal urine output (HP:0012590)1.73444892
101Cystic liver disease (HP:0006706)1.73067523
102Optic disc pallor (HP:0000543)1.72970336
103Dandy-Walker malformation (HP:0001305)1.72703221
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72338009
105Postaxial hand polydactyly (HP:0001162)1.71379326
106Mitochondrial inheritance (HP:0001427)1.71320454
107Aganglionic megacolon (HP:0002251)1.69634895
108Concave nail (HP:0001598)1.68185317
109Bell-shaped thorax (HP:0001591)1.67102524
110Broad-based gait (HP:0002136)1.66036085
111Intestinal atresia (HP:0011100)1.64372125
112Anosmia (HP:0000458)1.64343164
1133-Methylglutaconic aciduria (HP:0003535)1.64111324
114Asplenia (HP:0001746)1.63441798
115Congenital, generalized hypertrichosis (HP:0004540)1.61786169
116Increased CSF lactate (HP:0002490)1.61337497
117Multicystic kidney dysplasia (HP:0000003)1.61154556
118Prominent nasal bridge (HP:0000426)1.59413976
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59205918
120Abnormality of alanine metabolism (HP:0010916)1.59205918
121Hyperalaninemia (HP:0003348)1.59205918
122Poor coordination (HP:0002370)1.58256197
123Midline defect of the nose (HP:0004122)1.56231945
124Retrobulbar optic neuritis (HP:0100654)1.51531967
125Optic neuritis (HP:0100653)1.51531967
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.51011149
127Broad distal phalanx of finger (HP:0009836)1.48875201
128Omphalocele (HP:0001539)1.46303986
129Encephalitis (HP:0002383)1.45632336
130Joint swelling (HP:0001386)1.43897904
131Sclerocornea (HP:0000647)1.43560276
132Impulsivity (HP:0100710)1.42591009
133Abnormality of the phalanges of the hallux (HP:0010057)1.42516334
134Stage 5 chronic kidney disease (HP:0003774)1.38368361
135Bifid tongue (HP:0010297)1.36098194
136Increased serum ferritin (HP:0003281)1.34884406
137Deformed sella turcica (HP:0002681)1.34867129
138Preaxial hand polydactyly (HP:0001177)1.33392980
139Abnormal albumin level (HP:0012116)1.31245398
140Hypoalbuminemia (HP:0003073)1.31245398
141Oculomotor apraxia (HP:0000657)1.31041287
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.30935286
143Constricted visual fields (HP:0001133)1.30672440
144Abnormal lung lobation (HP:0002101)1.29930667
145Short ribs (HP:0000773)1.28495656
146Aplasia/Hypoplasia of the lens (HP:0008063)1.27015698
147Abnormality of intracranial pressure (HP:0012640)1.26950879
148Increased intracranial pressure (HP:0002516)1.26950879
149Subcapsular cataract (HP:0000523)1.25739871
15011 pairs of ribs (HP:0000878)1.25449818
151Buphthalmos (HP:0000557)1.25188295
152Abnormality of the renal cortex (HP:0011035)1.24063938
153Hypertriglyceridemia (HP:0002155)1.22952676
154Striae distensae (HP:0001065)1.22812312
155Amyotrophic lateral sclerosis (HP:0007354)1.21359917
156Taurodontia (HP:0000679)1.20875087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.86487310
2PDK45.64164069
3PDK35.64164069
4FRK5.07060271
5PRKD33.75334563
6GRK73.70493300
7PDK23.26106571
8MAP4K23.02223027
9TXK2.85133098
10PLK42.71635581
11WNK32.62957841
12NEK22.59658516
13BMPR1B2.59304169
14ZAK2.58492171
15STK102.33399213
16PINK12.28767887
17PNCK2.28364191
18ICK2.23980167
19GRK12.20287590
20MAPK132.08542756
21TAOK32.01321445
22NUAK11.99798848
23CDC71.98779171
24ACVR1B1.94022223
25LMTK21.85288115
26INSRR1.81286893
27MAP4K11.80705761
28TRIM281.79947515
29TLK11.76881941
30MAP3K41.74612087
31CASK1.68073320
32MAPK151.62665453
33ITK1.60830472
34OXSR11.56150642
35PTK2B1.52192676
36DYRK1B1.51763903
37WNK41.50859704
38TNIK1.48895291
39MST41.32656945
40DYRK31.26026769
41DYRK21.25870316
42STK391.20668994
43MARK11.17195197
44TIE11.16398716
45BRSK21.12561887
46ADRBK21.07864627
47STK381.04764921
48JAK11.04108432
49BRSK11.03209414
50ZAP701.02832984
51PLK21.02223734
52BCKDK0.98068208
53MAP2K70.97897467
54ADRBK10.97895367
55PIK3CG0.97692283
56PRKCG0.95981167
57PRKCE0.95856273
58VRK10.94651110
59LIMK10.93593490
60NTRK30.92781335
61CAMKK20.92414111
62PASK0.91094210
63MAPKAPK30.90851934
64ERBB30.89200873
65DAPK20.85916392
66SRPK10.83449750
67MAP3K20.79882130
68TGFBR20.77526940
69CSK0.77303503
70EEF2K0.77132575
71MAP3K120.77000121
72TYRO30.75981080
73MAP3K100.75777800
74MKNK20.73410239
75CDK120.72969143
76CSNK1G20.72504316
77CDK190.71329556
78TGFBR10.71107697
79CDK40.70931733
80PRKCH0.69621830
81PRKCQ0.69570891
82CSNK1G30.69329124
83RPS6KB20.68646608
84CSNK1G10.68482388
85STK30.66416370
86SIK30.63603995
87PDK10.62812861
88CDK60.62583516
89PAK40.61754294
90PIK3CA0.61634200
91STK240.60627813
92TESK20.60196271
93ERBB20.60121704
94STK110.58163414
95PLK30.56102748
96RPS6KA50.55900534
97FER0.55724600
98SIK20.55700579
99MAP3K110.55580229
100CSNK1A1L0.55236407
101MUSK0.54959975
102CAMK2A0.53378265
103IKBKB0.52194106
104PRKACA0.51808678
105PKN10.50354219
106CHUK0.49949405
107MAP2K60.49913382
108KIT0.48540833
109DYRK1A0.47970457
110IRAK10.47826517
111AURKA0.47006811
112FGFR20.46497925
113CSNK1A10.46227628
114WNK10.45554750
115CAMK10.43732652
116LRRK20.43412969
117MKNK10.42083166
118PRKCZ0.41193330
119LCK0.40580300
120NEK60.40392478
121PRKCA0.39614507
122PAK10.39330502
123TNK20.39315820
124FLT30.39168664
125PDGFRB0.38656068
126ALK0.38435973
127TEC0.37205532
128MARK30.36951510
129CHEK10.36873476
130MINK10.35569544
131MELK0.34920793
132PRKAA10.34892071
133EPHA40.34597320
134TRPM70.34192411
135CSNK1D0.34075009
136EPHA30.33897347
137MAPKAPK50.33025814
138TRIB30.31967737
139ABL10.29366655
140PIM10.28008458
141BCR0.27830162
142EPHB10.27182163
143NTRK20.26894079
144TTN0.24257740
145FES0.24227843
146CLK10.22561456
147PAK30.22272102
148OBSCN0.21716587
149PLK10.21329424
150ATM0.20882239
151ILK0.20104570
152STK38L0.19704696
153AURKB0.19546844
154INSR0.19389763
155WEE10.19179887
156IGF1R0.17861275
157TAOK10.17798787
158PTK60.16221526
159PRKG10.15585674
160RPS6KA10.15122099
161PHKG20.14834492
162PHKG10.14834492
163PAK60.13676422
164GRK60.13244503
165MAPKAPK20.12743376
166PRKCI0.12209884

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.81668340
2Allograft rejection_Homo sapiens_hsa053304.13151650
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.36359074
4Phototransduction_Homo sapiens_hsa047443.35377224
5Type I diabetes mellitus_Homo sapiens_hsa049403.23244315
6Autoimmune thyroid disease_Homo sapiens_hsa053203.15067929
7Basal transcription factors_Homo sapiens_hsa030222.64660523
8Nitrogen metabolism_Homo sapiens_hsa009102.55476721
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51813690
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49439645
11Antigen processing and presentation_Homo sapiens_hsa046122.45499129
12Viral myocarditis_Homo sapiens_hsa054162.29526338
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28778268
14Butanoate metabolism_Homo sapiens_hsa006502.26740013
15Oxidative phosphorylation_Homo sapiens_hsa001902.17648636
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06285896
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.05483991
18Nicotine addiction_Homo sapiens_hsa050332.04650655
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02389322
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89947480
21Protein export_Homo sapiens_hsa030601.89182566
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.84118698
23Caffeine metabolism_Homo sapiens_hsa002321.80083842
24Ether lipid metabolism_Homo sapiens_hsa005651.75044145
25RNA polymerase_Homo sapiens_hsa030201.73377569
26Glucagon signaling pathway_Homo sapiens_hsa049221.71594396
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62447233
28Parkinsons disease_Homo sapiens_hsa050121.61825334
29Huntingtons disease_Homo sapiens_hsa050161.61571055
30Tryptophan metabolism_Homo sapiens_hsa003801.60310877
31T cell receptor signaling pathway_Homo sapiens_hsa046601.57185423
32Pyruvate metabolism_Homo sapiens_hsa006201.55430902
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55413673
34Olfactory transduction_Homo sapiens_hsa047401.52009029
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47875776
36mRNA surveillance pathway_Homo sapiens_hsa030151.47328873
37Homologous recombination_Homo sapiens_hsa034401.45338431
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45269586
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43113563
40Taste transduction_Homo sapiens_hsa047421.41336364
41Selenocompound metabolism_Homo sapiens_hsa004501.41185780
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35555275
43Peroxisome_Homo sapiens_hsa041461.31557053
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.27805184
45Fatty acid biosynthesis_Homo sapiens_hsa000611.27126355
46Morphine addiction_Homo sapiens_hsa050321.26056878
47Oocyte meiosis_Homo sapiens_hsa041141.25460491
48Acute myeloid leukemia_Homo sapiens_hsa052211.23849657
49ABC transporters_Homo sapiens_hsa020101.23791735
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.23667376
51Epstein-Barr virus infection_Homo sapiens_hsa051691.21963365
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.17799513
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15717777
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13987346
55Retinol metabolism_Homo sapiens_hsa008301.13705107
56Cell cycle_Homo sapiens_hsa041101.13451161
57Regulation of autophagy_Homo sapiens_hsa041401.12314771
58Viral carcinogenesis_Homo sapiens_hsa052031.08536982
59Cardiac muscle contraction_Homo sapiens_hsa042601.03568457
60Spliceosome_Homo sapiens_hsa030401.01793388
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01716967
62Collecting duct acid secretion_Homo sapiens_hsa049661.00254992
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99939848
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96846404
65RNA transport_Homo sapiens_hsa030130.95949918
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94754207
67Insulin secretion_Homo sapiens_hsa049110.94503225
68Notch signaling pathway_Homo sapiens_hsa043300.94221310
69Serotonergic synapse_Homo sapiens_hsa047260.92070414
70Circadian entrainment_Homo sapiens_hsa047130.91651319
71Alzheimers disease_Homo sapiens_hsa050100.91299185
72GABAergic synapse_Homo sapiens_hsa047270.89442631
73Hedgehog signaling pathway_Homo sapiens_hsa043400.88085889
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86908347
75Propanoate metabolism_Homo sapiens_hsa006400.83977050
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82612684
77Glutamatergic synapse_Homo sapiens_hsa047240.82598539
78Asthma_Homo sapiens_hsa053100.82130484
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81788764
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81514926
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79963315
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76170563
83Amphetamine addiction_Homo sapiens_hsa050310.76049695
84Dorso-ventral axis formation_Homo sapiens_hsa043200.75569717
85Salivary secretion_Homo sapiens_hsa049700.75508037
86Glutathione metabolism_Homo sapiens_hsa004800.75025198
87beta-Alanine metabolism_Homo sapiens_hsa004100.74911843
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74022630
89Primary immunodeficiency_Homo sapiens_hsa053400.73291493
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73172557
91Endocytosis_Homo sapiens_hsa041440.71897665
92Fat digestion and absorption_Homo sapiens_hsa049750.71579878
93Circadian rhythm_Homo sapiens_hsa047100.70627877
94Tight junction_Homo sapiens_hsa045300.70149919
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69152136
96Measles_Homo sapiens_hsa051620.67765399
97Long-term potentiation_Homo sapiens_hsa047200.67557875
98Ovarian steroidogenesis_Homo sapiens_hsa049130.66232421
99Histidine metabolism_Homo sapiens_hsa003400.66017902
100Metabolic pathways_Homo sapiens_hsa011000.65895740
101Fanconi anemia pathway_Homo sapiens_hsa034600.65436800
102Basal cell carcinoma_Homo sapiens_hsa052170.64272790
103HTLV-I infection_Homo sapiens_hsa051660.64173307
104Legionellosis_Homo sapiens_hsa051340.64005926
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63853300
106Vitamin B6 metabolism_Homo sapiens_hsa007500.63570906
107Fatty acid degradation_Homo sapiens_hsa000710.63198329
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62868990
109Shigellosis_Homo sapiens_hsa051310.60943915
110Chemical carcinogenesis_Homo sapiens_hsa052040.60928637
111Calcium signaling pathway_Homo sapiens_hsa040200.60595494
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.60572307
113Arachidonic acid metabolism_Homo sapiens_hsa005900.59980697
114Estrogen signaling pathway_Homo sapiens_hsa049150.59464634
115Hippo signaling pathway_Homo sapiens_hsa043900.56148708
116Sulfur metabolism_Homo sapiens_hsa009200.54805955
117RNA degradation_Homo sapiens_hsa030180.54805454
118Adherens junction_Homo sapiens_hsa045200.54706688
119Chronic myeloid leukemia_Homo sapiens_hsa052200.54200673
120Dopaminergic synapse_Homo sapiens_hsa047280.52428945
121VEGF signaling pathway_Homo sapiens_hsa043700.52131733
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51824271
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51238394
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51123319
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50179817
126Apoptosis_Homo sapiens_hsa042100.49957431
127Toxoplasmosis_Homo sapiens_hsa051450.49923793
128Alcoholism_Homo sapiens_hsa050340.49271600
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48257167
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46845975
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.45222005
132Cocaine addiction_Homo sapiens_hsa050300.44673989
133Renin secretion_Homo sapiens_hsa049240.44137894
134One carbon pool by folate_Homo sapiens_hsa006700.43357470
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43141747
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43021723
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42793347
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41877735
139B cell receptor signaling pathway_Homo sapiens_hsa046620.41851163
140TGF-beta signaling pathway_Homo sapiens_hsa043500.41266571
141Wnt signaling pathway_Homo sapiens_hsa043100.41065115
142Proteasome_Homo sapiens_hsa030500.41018794
143AMPK signaling pathway_Homo sapiens_hsa041520.40180755
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39431729
145Linoleic acid metabolism_Homo sapiens_hsa005910.39154847
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38990915
147Hepatitis B_Homo sapiens_hsa051610.37605963
148Mineral absorption_Homo sapiens_hsa049780.35771797
149Malaria_Homo sapiens_hsa051440.34981183
150Fatty acid metabolism_Homo sapiens_hsa012120.32014670
151Focal adhesion_Homo sapiens_hsa045100.31409728
152Synaptic vesicle cycle_Homo sapiens_hsa047210.30960702
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29978013
154Ribosome_Homo sapiens_hsa030100.28940643
155Purine metabolism_Homo sapiens_hsa002300.27931695
156Pyrimidine metabolism_Homo sapiens_hsa002400.27716842
157Insulin signaling pathway_Homo sapiens_hsa049100.27642988
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27636605
159Endometrial cancer_Homo sapiens_hsa052130.26265108
160Colorectal cancer_Homo sapiens_hsa052100.25735053
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25586591
162Glycerolipid metabolism_Homo sapiens_hsa005610.24097763
163Intestinal immune network for IgA production_Homo sapiens_hsa046720.22643627
164Salmonella infection_Homo sapiens_hsa051320.22214026
165Pathways in cancer_Homo sapiens_hsa052000.21798167
166Non-homologous end-joining_Homo sapiens_hsa034500.21093791
167Systemic lupus erythematosus_Homo sapiens_hsa053220.21072254

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