ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	5.99970871
2	mitotic sister chromatid segregation (GO:0000070)	5.97196711
3	sister chromatid segregation (GO:0000819)	5.59464007
4	mitotic metaphase plate congression (GO:0007080)	5.56834702
5	mitotic chromosome condensation (GO:0007076)	5.33386081
6	CENP-A containing nucleosome assembly (GO:0034080)	5.12896367
7	chromatin remodeling at centromere (GO:0031055)	5.04009900
8	kinetochore organization (GO:0051383)	4.95155966
9	metaphase plate congression (GO:0051310)	4.89557365
10	protein localization to kinetochore (GO:0034501)	4.83066995
11	protein localization to chromosome, centromeric region (GO:0071459)	4.69110688
12	establishment of integrated proviral latency (GO:0075713)	4.53186181
13	spindle checkpoint (GO:0031577)	4.48440627
14	histone exchange (GO:0043486)	4.37615844
15	negative regulation of chromosome segregation (GO:0051985)	4.34884964
16	mitotic spindle checkpoint (GO:0071174)	4.33588013
17	DNA ligation (GO:0006266)	4.32370540
18	negative regulation of sister chromatid segregation (GO:0033046)	4.30918955
19	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	4.30918955
20	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	4.30918955
21	negative regulation of mitotic sister chromatid segregation (GO:0033048)	4.30918955
22	negative regulation of mitotic sister chromatid separation (GO:2000816)	4.30918955
23	proteasome assembly (GO:0043248)	4.29889560
24	establishment of chromosome localization (GO:0051303)	4.28590161
25	DNA topological change (GO:0006265)	4.25955441
26	regulation of chromosome segregation (GO:0051983)	4.23697834
27	kinetochore assembly (GO:0051382)	4.23490623
28	DNA strand elongation involved in DNA replication (GO:0006271)	4.16993783
29	mitotic spindle assembly checkpoint (GO:0007094)	4.16119882
30	regulation of mitotic spindle organization (GO:0060236)	4.11190659
31	DNA replication-independent nucleosome assembly (GO:0006336)	4.11134867
32	DNA replication-independent nucleosome organization (GO:0034724)	4.11134867
33	spindle assembly checkpoint (GO:0071173)	4.09611625
34	mitotic nuclear envelope disassembly (GO:0007077)	4.04362211
35	DNA unwinding involved in DNA replication (GO:0006268)	4.02252003
36	regulation of spindle organization (GO:0090224)	4.01570105
37	DNA strand elongation (GO:0022616)	4.01313017
38	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.99194166
39	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.99194166
40	attachment of spindle microtubules to kinetochore (GO:0008608)	3.97793670
41	telomere maintenance via semi-conservative replication (GO:0032201)	3.91764132
42	regulation of sister chromatid segregation (GO:0033045)	3.85549685
43	regulation of mitotic sister chromatid separation (GO:0010965)	3.85549685
44	regulation of mitotic sister chromatid segregation (GO:0033047)	3.85549685
45	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.83850869
46	nuclear pore complex assembly (GO:0051292)	3.81827303
47	nuclear envelope disassembly (GO:0051081)	3.77188120
48	membrane disassembly (GO:0030397)	3.77188120
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.76245387
50	ribosome assembly (GO:0042255)	3.71462761
51	regulation of centriole replication (GO:0046599)	3.65986593
52	chromosome segregation (GO:0007059)	3.64412159
53	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.59541535
54	positive regulation of chromosome segregation (GO:0051984)	3.56079591
55	regulation of centrosome cycle (GO:0046605)	3.54118473
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.54043550
57	negative regulation of mitosis (GO:0045839)	3.49447875
58	DNA double-strand break processing (GO:0000729)	3.45805823
59	chromosome condensation (GO:0030261)	3.42149719
60	IMP biosynthetic process (GO:0006188)	3.39384129
61	mitotic recombination (GO:0006312)	3.38345817
62	DNA replication checkpoint (GO:0000076)	3.38140880
63	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.35934951
64	negative regulation of ligase activity (GO:0051352)	3.35934951
65	nuclear pore organization (GO:0006999)	3.35408157
66	protein localization to chromosome (GO:0034502)	3.34643960
67	microtubule depolymerization (GO:0007019)	3.34485711
68	ventricular cardiac muscle cell development (GO:0055015)	3.33605821
69	establishment of viral latency (GO:0019043)	3.33426461
70	telomere maintenance via recombination (GO:0000722)	3.29978294
71	DNA replication initiation (GO:0006270)	3.28858892
72	purine nucleobase biosynthetic process (GO:0009113)	3.27825633
73	DNA replication-dependent nucleosome assembly (GO:0006335)	3.27555829
74	DNA replication-dependent nucleosome organization (GO:0034723)	3.27555829
75	mitotic sister chromatid cohesion (GO:0007064)	3.27099022
76	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.24658855
77	ATP-dependent chromatin remodeling (GO:0043044)	3.23966942
78	protein complex localization (GO:0031503)	3.17417988
79	mitotic spindle organization (GO:0007052)	3.16230730
80	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.15193313
81	nucleobase biosynthetic process (GO:0046112)	3.14228580
82	negative regulation of nuclear division (GO:0051784)	3.10956231
83	deoxyribonucleotide biosynthetic process (GO:0009263)	3.10815979
84	chromatin assembly or disassembly (GO:0006333)	3.08108459
85	mitotic cell cycle (GO:0000278)	3.08007927
86	meiotic chromosome segregation (GO:0045132)	3.07299009
87	negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)	3.06781499
88	DNA packaging (GO:0006323)	3.05474953
89	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.05292893
90	positive regulation of ligase activity (GO:0051351)	3.01804106
91	cellular protein complex localization (GO:0034629)	2.98718422
92	regulation of centrosome duplication (GO:0010824)	2.97226154
93	negative regulation of cell division (GO:0051782)	2.96963691
94	synapsis (GO:0007129)	2.95046839
95	regulation of ligase activity (GO:0051340)	2.94368447
96	regulation of sister chromatid cohesion (GO:0007063)	2.93282084
97	IMP metabolic process (GO:0046040)	2.92573716
98	telomere maintenance via telomere lengthening (GO:0010833)	2.91817267
99	nuclear envelope organization (GO:0006998)	2.91421460
100	G1/S transition of mitotic cell cycle (GO:0000082)	2.89012308

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.68928704
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	6.83668900
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.93899849
4	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.72082004
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35229549
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.57510304
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17656710
8	AR_21909140_ChIP-Seq_LNCAP_Human	3.12863346
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.06930191
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.03089514
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.94183692
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.85502921
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.81502923
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.74815438
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.70736423
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70541013
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.62356630
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.54318244
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.48109563
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44453267
21	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.42217339
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.38195237
23	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.37568955
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35184257
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.32692788
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.25381645
27	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.10705101
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.08794995
29	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07105305
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.95749273
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.95601331
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.91898722
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.90757938
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89212834
35	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.88880923
36	VDR_23849224_ChIP-Seq_CD4+_Human	1.82102822
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.80894253
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.80573536
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.69897996
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.69493544
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.66143757
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.65796926
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.64181283
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.60743169
45	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52635349
46	EWS_26573619_Chip-Seq_HEK293_Human	1.51690166
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49792936
48	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.42629885
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38399501
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.35839227
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.33175089
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.33134770
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.33103296
54	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.32884135
55	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.27233337
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.26956547
57	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26637973
58	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.23813197
59	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.22739852
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20344560
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.18463082
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15859482
63	KDM5A_27292631_Chip-Seq_BREAST_Human	1.12062694
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10029177
65	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06337584
66	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02364566
67	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02074244
68	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.99557226
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97424053
70	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.95541811
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91683519
72	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.91667310
73	IGF1R_20145208_ChIP-Seq_DFB_Human	0.90849668
74	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.89145996
75	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87170291
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87138855
77	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.86441951
78	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.85810447
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.83538093
80	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.82574179
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.82041978
82	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.81937397
83	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.79969645
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.79900771
85	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.79005081
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.77796794
87	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.77161720
88	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.73444193
89	FUS_26573619_Chip-Seq_HEK293_Human	0.73405930
90	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.73148668
91	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.71868122
92	TFEB_21752829_ChIP-Seq_HELA_Human	0.71645307
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.70313252
94	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.70067595
95	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.69942604
96	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.69518982
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.69242774
98	SOX9_26525672_Chip-Seq_HEART_Mouse	0.69043585
99	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.66621611
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.66302767

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	5.08641538
2	MP0003693_abnormal_embryo_hatching	5.01855047
3	MP0003111_abnormal_nucleus_morphology	4.85913194
4	MP0004957_abnormal_blastocyst_morpholog	4.72742388
5	MP0003077_abnormal_cell_cycle	3.82046054
6	MP0008058_abnormal_DNA_repair	3.79286760
7	MP0008057_abnormal_DNA_replication	3.22448963
8	MP0008932_abnormal_embryonic_tissue	3.11312067
9	MP0002102_abnormal_ear_morphology	2.47944741
10	MP0003718_maternal_effect	2.46416932
11	MP0008007_abnormal_cellular_replicative	2.32694638
12	MP0003941_abnormal_skin_development	2.17867969
13	MP0001730_embryonic_growth_arrest	2.09232527
14	MP0003890_abnormal_embryonic-extraembry	1.99839700
15	MP0009697_abnormal_copulation	1.94878967
16	MP0000350_abnormal_cell_proliferation	1.79152405
17	MP0003786_premature_aging	1.72278177
18	MP0010030_abnormal_orbit_morphology	1.67637657
19	MP0005380_embryogenesis_phenotype	1.67393226
20	MP0001672_abnormal_embryogenesis/_devel	1.67393226
21	MP0001697_abnormal_embryo_size	1.66821426
22	MP0010307_abnormal_tumor_latency	1.60704856
23	MP0002085_abnormal_embryonic_tissue	1.58598550
24	MP0003937_abnormal_limbs/digits/tail_de	1.56517678
25	MP0002080_prenatal_lethality	1.52126560
26	MP0001293_anophthalmia	1.48341537
27	MP0001529_abnormal_vocalization	1.45619474
28	MP0006035_abnormal_mitochondrial_morpho	1.44456306
29	MP0006292_abnormal_olfactory_placode	1.43339347
30	MP0000372_irregular_coat_pigmentation	1.41696293
31	MP0010352_gastrointestinal_tract_polyps	1.40892990
32	MP0002084_abnormal_developmental_patter	1.36936863
33	MP0009672_abnormal_birth_weight	1.32102737
34	MP0003984_embryonic_growth_retardation	1.29449087
35	MP0002796_impaired_skin_barrier	1.27790323
36	MP0002210_abnormal_sex_determination	1.25273371
37	MP0002088_abnormal_embryonic_growth/wei	1.24225187
38	MP0003806_abnormal_nucleotide_metabolis	1.22809152
39	MP0008877_abnormal_DNA_methylation	1.21466364
40	MP0001929_abnormal_gametogenesis	1.20316450
41	MP0010234_abnormal_vibrissa_follicle	1.18893902
42	MP0000313_abnormal_cell_death	1.17488053
43	MP0002111_abnormal_tail_morphology	1.15975337
44	MP0001188_hyperpigmentation	1.15894514
45	MP0003119_abnormal_digestive_system	1.14289972
46	MP0006036_abnormal_mitochondrial_physio	1.12956638
47	MP0003123_paternal_imprinting	1.12850855
48	MP0002234_abnormal_pharynx_morphology	1.10357329
49	MP0002938_white_spotting	1.09452037
50	MP0002736_abnormal_nociception_after	1.08418829
51	MP0002086_abnormal_extraembryonic_tissu	1.07377762
52	MP0000579_abnormal_nail_morphology	1.05655147
53	MP0001661_extended_life_span	1.05083952
54	MP0009703_decreased_birth_body	1.03261678
55	MP0004197_abnormal_fetal_growth/weight/	1.02228542
56	MP0001145_abnormal_male_reproductive	0.97340628
57	MP0003755_abnormal_palate_morphology	0.97162166
58	MP0005501_abnormal_skin_physiology	0.96158005
59	MP0002233_abnormal_nose_morphology	0.95946080
60	MP0000358_abnormal_cell_content/	0.94497146
61	MP0000647_abnormal_sebaceous_gland	0.92257934
62	MP0002160_abnormal_reproductive_system	0.90964580
63	MP0000653_abnormal_sex_gland	0.90784295
64	MP0002697_abnormal_eye_size	0.89800848
65	MP0000537_abnormal_urethra_morphology	0.85368384
66	MP0008789_abnormal_olfactory_epithelium	0.85298697
67	MP0003861_abnormal_nervous_system	0.82827058
68	MP0000049_abnormal_middle_ear	0.81937922
69	MP0001286_abnormal_eye_development	0.81000596
70	MP0003698_abnormal_male_reproductive	0.79432929
71	MP0001177_atelectasis	0.78776933
72	MP0004147_increased_porphyrin_level	0.78296485
73	MP0006054_spinal_hemorrhage	0.78062138
74	MP0003935_abnormal_craniofacial_develop	0.77654990
75	MP0004233_abnormal_muscle_weight	0.76731420
76	MP0000490_abnormal_crypts_of	0.76727600
77	MP0005395_other_phenotype	0.76308956
78	MP0000428_abnormal_craniofacial_morphol	0.74791202
79	MP0002161_abnormal_fertility/fecundity	0.74362493
80	MP0002060_abnormal_skin_morphology	0.74219907
81	MP0003567_abnormal_fetal_cardiomyocyte	0.73912802
82	MP0003385_abnormal_body_wall	0.73910407
83	MP0003137_abnormal_impulse_conducting	0.73587130
84	MP0002396_abnormal_hematopoietic_system	0.70880359
85	MP0003950_abnormal_plasma_membrane	0.70399024
86	MP0004185_abnormal_adipocyte_glucose	0.69796830
87	MP0002019_abnormal_tumor_incidence	0.69011058
88	MP0002177_abnormal_outer_ear	0.67760344
89	MP0001727_abnormal_embryo_implantation	0.67401396
90	MP0003699_abnormal_female_reproductive	0.64756114
91	MP0000432_abnormal_head_morphology	0.62095305
92	MP0003221_abnormal_cardiomyocyte_apopto	0.61781138
93	MP0002095_abnormal_skin_pigmentation	0.61465474
94	MP0000462_abnormal_digestive_system	0.60428391
95	MP0002877_abnormal_melanocyte_morpholog	0.59641378
96	MP0001119_abnormal_female_reproductive	0.59549757
97	MP0002269_muscular_atrophy	0.59340075
98	MP0002114_abnormal_axial_skeleton	0.58755872
99	MP0002751_abnormal_autonomic_nervous	0.58467216
100	MP0002092_abnormal_eye_morphology	0.57414582

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	3.98642434
2	Increased serum pyruvate (HP:0003542)	3.72454026
3	Abnormal lung lobation (HP:0002101)	3.66493950
4	Abnormality of glycolysis (HP:0004366)	3.62757940
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.55833745
6	Birth length less than 3rd percentile (HP:0003561)	3.28017811
7	Increased nuchal translucency (HP:0010880)	3.27796586
8	Chromsome breakage (HP:0040012)	3.24355002
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.12319516
10	Abnormality of the preputium (HP:0100587)	3.06369227
11	Meckel diverticulum (HP:0002245)	3.04607699
12	Progressive external ophthalmoplegia (HP:0000590)	3.01373128
13	Abnormality of chromosome stability (HP:0003220)	2.95832024
14	Small intestinal stenosis (HP:0012848)	2.93638237
15	Duodenal stenosis (HP:0100867)	2.93638237
16	Abnormality of the ileum (HP:0001549)	2.84649963
17	Colon cancer (HP:0003003)	2.80204660
18	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.75011826
19	Embryonal renal neoplasm (HP:0011794)	2.67102230
20	Nephroblastoma (Wilms tumor) (HP:0002667)	2.57021265
21	Abnormality of the labia minora (HP:0012880)	2.56007989
22	Increased hepatocellular lipid droplets (HP:0006565)	2.51479289
23	Prominent metopic ridge (HP:0005487)	2.50858283
24	Abnormality of the duodenum (HP:0002246)	2.48499143
25	Cerebral hypomyelination (HP:0006808)	2.45821316
26	Cortical dysplasia (HP:0002539)	2.45216138
27	Multiple enchondromatosis (HP:0005701)	2.40415911
28	Microvesicular hepatic steatosis (HP:0001414)	2.39306758
29	Hypoplastic pelvis (HP:0008839)	2.35045603
30	Acute encephalopathy (HP:0006846)	2.35000843
31	Facial cleft (HP:0002006)	2.32413637
32	Myelodysplasia (HP:0002863)	2.30128772
33	Sloping forehead (HP:0000340)	2.28588191
34	Glioma (HP:0009733)	2.27217432
35	Acute necrotizing encephalopathy (HP:0006965)	2.26819858
36	Ependymoma (HP:0002888)	2.25598449
37	Abnormal umbilical cord blood vessels (HP:0011403)	2.19922160
38	Single umbilical artery (HP:0001195)	2.19922160
39	Abnormality of the fetal cardiovascular system (HP:0010948)	2.19922160
40	Abnormality of the umbilical cord (HP:0010881)	2.16985064
41	Urethral obstruction (HP:0000796)	2.15077635
42	Myelomeningocele (HP:0002475)	2.14813146
43	Lipid accumulation in hepatocytes (HP:0006561)	2.14209971
44	Medulloblastoma (HP:0002885)	2.13368587
45	Horseshoe kidney (HP:0000085)	2.11002670
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.10184327
47	Abnormality of the metopic suture (HP:0005556)	2.10160862
48	Increased serum lactate (HP:0002151)	2.08621377
49	Hypoplasia of the pons (HP:0012110)	2.08241472
50	Abnormality of the carotid arteries (HP:0005344)	2.07535027
51	Astrocytoma (HP:0009592)	2.06867402
52	Abnormality of the astrocytes (HP:0100707)	2.06867402
53	Increased CSF lactate (HP:0002490)	2.04163360
54	Pancreatic islet-cell hyperplasia (HP:0004510)	2.01871152
55	Postnatal microcephaly (HP:0005484)	2.00058956
56	Squamous cell carcinoma (HP:0002860)	1.98628596
57	Proximal placement of thumb (HP:0009623)	1.97526711
58	Rhabdomyosarcoma (HP:0002859)	1.97250292
59	Clubbing of toes (HP:0100760)	1.96707247
60	Small hand (HP:0200055)	1.96570900
61	Absent radius (HP:0003974)	1.95751896
62	Aplasia/Hypoplasia of the patella (HP:0006498)	1.90995215
63	Abnormality of the pons (HP:0007361)	1.90775546
64	Bifid tongue (HP:0010297)	1.90428014
65	Abnormality of alanine metabolism (HP:0010916)	1.88955332
66	Hyperalaninemia (HP:0003348)	1.88955332
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88955332
68	Progressive muscle weakness (HP:0003323)	1.88387806
69	Aplasia involving forearm bones (HP:0009822)	1.88000453
70	Absent forearm bone (HP:0003953)	1.88000453
71	Patellar aplasia (HP:0006443)	1.87294406
72	Degeneration of anterior horn cells (HP:0002398)	1.87108964
73	Abnormality of the anterior horn cell (HP:0006802)	1.87108964
74	CNS hypomyelination (HP:0003429)	1.86271137
75	Selective tooth agenesis (HP:0001592)	1.85801853
76	Breast hypoplasia (HP:0003187)	1.84529911
77	Rough bone trabeculation (HP:0100670)	1.83556090
78	Neoplasm of the colon (HP:0100273)	1.81468895
79	Choanal atresia (HP:0000453)	1.81069547
80	Mitochondrial inheritance (HP:0001427)	1.80352453
81	Deviation of the thumb (HP:0009603)	1.75555629
82	Premature ovarian failure (HP:0008209)	1.75186938
83	Progressive macrocephaly (HP:0004481)	1.75084398
84	Abnormalities of placenta or umbilical cord (HP:0001194)	1.74520422
85	Dandy-Walker malformation (HP:0001305)	1.71685202
86	Preaxial hand polydactyly (HP:0001177)	1.71396074
87	Abnormality of chromosome segregation (HP:0002916)	1.68260967
88	Progressive inability to walk (HP:0002505)	1.68132162
89	Arteriovenous malformation (HP:0100026)	1.67564611
90	Posterior subcapsular cataract (HP:0007787)	1.67520534
91	Lactic acidosis (HP:0003128)	1.67475201
92	Anal atresia (HP:0002023)	1.67201076
93	Cafe-au-lait spot (HP:0000957)	1.66717208
94	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.66639132
95	Abnormality of abdominal situs (HP:0011620)	1.66354972
96	Abdominal situs inversus (HP:0003363)	1.66354972
97	Carpal bone hypoplasia (HP:0001498)	1.66339823
98	Cerebral edema (HP:0002181)	1.66276667
99	Neoplasm of the adrenal cortex (HP:0100641)	1.65649718
100	Short middle phalanx of the 5th finger (HP:0004220)	1.63431898

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	7.04097464
2	NEK1	6.09527099
3	PLK4	3.32562378
4	TTK	3.28988186
5	NEK2	2.99312264
6	VRK2	2.91889542
7	WEE1	2.87994368
8	CDC7	2.78294800
9	EIF2AK1	2.44488031
10	TSSK6	2.41329953
11	PLK3	2.35045541
12	EIF2AK3	2.24842409
13	SRPK1	2.13045006
14	MKNK2	2.09732297
15	PBK	1.99540507
16	PLK1	1.84855909
17	MST4	1.79247207
18	VRK1	1.75678437
19	ZAK	1.71759605
20	MKNK1	1.71285661
21	TRIM28	1.69946299
22	TNIK	1.62677975
23	BRAF	1.46706518
24	AURKB	1.27656554
25	BRSK1	1.26919844
26	NUAK1	1.25661126
27	CHEK2	1.23758546
28	STK10	1.16544339
29	BRSK2	1.13594823
30	CCNB1	1.12866097
31	MAP3K10	1.08853370
32	STK16	1.07234684
33	ATR	1.05202034
34	EPHA4	1.03876356
35	TAF1	1.01748909
36	AURKA	1.01519900
37	EIF2AK2	0.98325285
38	MAP3K8	0.96451983
39	STK3	0.88637689
40	NME2	0.85480458
41	CHEK1	0.84227281
42	MAP4K2	0.83015454
43	ERBB3	0.82137370
44	SMG1	0.79259497
45	WNK3	0.74205375
46	CDK7	0.73335006
47	NTRK3	0.68611058
48	DYRK3	0.68077836
49	BCR	0.67951832
50	ATM	0.66972397
51	RPS6KA4	0.66298202
52	MAPK13	0.64786550
53	NME1	0.64449474
54	PDK2	0.63419386
55	PNCK	0.62725834
56	SCYL2	0.59989421
57	PAK4	0.59763017
58	ALK	0.58248389
59	LATS2	0.57305244
60	STK4	0.56590608
61	CDK1	0.55526390
62	MST1R	0.53826918
63	CLK1	0.50070361
64	TLK1	0.49532629
65	CDK2	0.46649739
66	CSNK1E	0.42892276
67	PLK2	0.41289067
68	SIK3	0.41101799
69	MARK3	0.40713957
70	CSNK2A1	0.40422254
71	MAPKAPK5	0.37085931
72	UHMK1	0.36512954
73	PAK1	0.35720963
74	MINK1	0.35306139
75	CSNK2A2	0.35095642
76	NEK6	0.35087943
77	RPS6KB2	0.34934404
78	CDK3	0.34801434
79	CDK8	0.34319359
80	PRKCI	0.33137129
81	CDK9	0.32594574
82	EEF2K	0.32212656
83	DMPK	0.32194852
84	CDK18	0.31942481
85	PASK	0.31851568
86	IRAK2	0.31106434
87	CSNK1G3	0.30233222
88	IRAK3	0.30001858
89	AKT2	0.29202931
90	BRD4	0.28785847
91	CDK4	0.28640162
92	ROCK2	0.28276615
93	CDK14	0.27363453
94	CDK15	0.26058648
95	CDK6	0.25276881
96	MELK	0.25211773
97	CDK11A	0.25076311
98	CSNK1G1	0.24749517
99	ILK	0.22229171
100	YES1	0.19415467

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.06378792
2	DNA replication_Homo sapiens_hsa03030	4.06184157
3	Mismatch repair_Homo sapiens_hsa03430	3.58207650
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.20261323
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.18417312
6	Cell cycle_Homo sapiens_hsa04110	2.98883344
7	Homologous recombination_Homo sapiens_hsa03440	2.96198517
8	RNA transport_Homo sapiens_hsa03013	2.59062912
9	Spliceosome_Homo sapiens_hsa03040	2.53747468
10	Base excision repair_Homo sapiens_hsa03410	2.46910982
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.44649466
12	RNA polymerase_Homo sapiens_hsa03020	2.42660047
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.35107860
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26578255
15	Basal transcription factors_Homo sapiens_hsa03022	2.24338820
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.12379684
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.07598548
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99768873
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.86565630
20	One carbon pool by folate_Homo sapiens_hsa00670	1.86524949
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86429789
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.84546690
23	RNA degradation_Homo sapiens_hsa03018	1.81168111
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.56115129
25	mRNA surveillance pathway_Homo sapiens_hsa03015	1.54839201
26	Oocyte meiosis_Homo sapiens_hsa04114	1.47067685
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46913988
28	p53 signaling pathway_Homo sapiens_hsa04115	1.45401692
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.44462678
30	Protein export_Homo sapiens_hsa03060	1.34534924
31	Ribosome_Homo sapiens_hsa03010	1.30757672
32	Propanoate metabolism_Homo sapiens_hsa00640	1.29686844
33	Parkinsons disease_Homo sapiens_hsa05012	1.28114710
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27996446
35	Purine metabolism_Homo sapiens_hsa00230	1.26725396
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.26405320
37	Huntingtons disease_Homo sapiens_hsa05016	1.14318521
38	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09513463
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.08658573
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.08318841
41	Fatty acid elongation_Homo sapiens_hsa00062	1.06570585
42	Carbon metabolism_Homo sapiens_hsa01200	1.01376907
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00850243
44	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.99273297
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.97223192
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.96486329
47	Sulfur relay system_Homo sapiens_hsa04122	0.92906048
48	Glutathione metabolism_Homo sapiens_hsa00480	0.91528546
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.85264252
50	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.79558805
51	Sulfur metabolism_Homo sapiens_hsa00920	0.75416506
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71702737
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71667756
54	Alzheimers disease_Homo sapiens_hsa05010	0.66456130
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.64219401
56	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.63642215
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61171541
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58297281
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.54442938
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.50498487
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50224012
62	Metabolic pathways_Homo sapiens_hsa01100	0.48933881
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.48637992
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.47569273
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.46465014
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43953436
67	Folate biosynthesis_Homo sapiens_hsa00790	0.43119679
68	Phototransduction_Homo sapiens_hsa04744	0.42270243
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42246952
70	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.41532134
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41473585
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.37956236
73	Butanoate metabolism_Homo sapiens_hsa00650	0.37404787
74	MicroRNAs in cancer_Homo sapiens_hsa05206	0.31868114
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.31811758
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31548747
77	Colorectal cancer_Homo sapiens_hsa05210	0.30976206
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.27922916
79	Lysine degradation_Homo sapiens_hsa00310	0.26569961
80	HTLV-I infection_Homo sapiens_hsa05166	0.25893648
81	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.24262627
82	Adherens junction_Homo sapiens_hsa04520	0.23228634
83	Taste transduction_Homo sapiens_hsa04742	0.22053949
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20914769
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20051849
86	Alcoholism_Homo sapiens_hsa05034	0.19192694
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.19123352
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.18088997
89	Tight junction_Homo sapiens_hsa04530	0.17724413
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.17193698
91	Thyroid cancer_Homo sapiens_hsa05216	0.12813579
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.12809094
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.11462759
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.11317324
95	Prostate cancer_Homo sapiens_hsa05215	0.09938383
96	Small cell lung cancer_Homo sapiens_hsa05222	0.08122905
97	Melanoma_Homo sapiens_hsa05218	0.07459934
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.02864098
99	Fatty acid degradation_Homo sapiens_hsa00071	0.02794199
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.00477009

CDC20P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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