CDC25B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid segregation (GO:0000070)7.10183043
2sister chromatid segregation (GO:0000819)6.85909038
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.65520122
4protoporphyrinogen IX metabolic process (GO:0046501)5.71619273
5mitotic chromosome condensation (GO:0007076)5.65579858
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.46333573
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.46333573
8positive regulation of mitotic sister chromatid separation (GO:1901970)5.46333573
9protoporphyrinogen IX biosynthetic process (GO:0006782)5.26143357
10protein localization to chromosome, centromeric region (GO:0071459)5.17399422
11protein localization to kinetochore (GO:0034501)5.13388319
12positive regulation of chromosome segregation (GO:0051984)5.06362096
13DNA unwinding involved in DNA replication (GO:0006268)4.58890652
14mitotic metaphase plate congression (GO:0007080)4.58845817
15kinetochore organization (GO:0051383)4.46842115
16regulation of exit from mitosis (GO:0007096)4.46431224
17regulation of spindle organization (GO:0090224)4.45025396
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33999095
19regulation of mitotic spindle organization (GO:0060236)4.32469452
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.29394552
21establishment of chromosome localization (GO:0051303)4.24488507
22protein localization to chromosome (GO:0034502)4.15876285
23metaphase plate congression (GO:0051310)4.11774335
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09378095
25negative regulation of cell killing (GO:0031342)4.09378095
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08676911
27microtubule depolymerization (GO:0007019)4.05297659
28regulation of chromosome segregation (GO:0051983)4.05114276
29thymic T cell selection (GO:0045061)4.04635718
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.01121744
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96850593
32attachment of spindle microtubules to kinetochore (GO:0008608)3.80975706
33leukocyte aggregation (GO:0070486)3.79124851
34chromosome segregation (GO:0007059)3.76720171
35antigen processing and presentation of endogenous antigen (GO:0019883)3.75694013
36mitotic nuclear envelope disassembly (GO:0007077)3.71985857
37meiotic chromosome segregation (GO:0045132)3.71099258
38kinetochore assembly (GO:0051382)3.71066361
39DNA topological change (GO:0006265)3.66510351
40spindle assembly checkpoint (GO:0071173)3.62015420
41chromosome condensation (GO:0030261)3.61746812
42negative regulation of chromosome segregation (GO:0051985)3.61481394
43spindle checkpoint (GO:0031577)3.59576076
44establishment of mitotic spindle localization (GO:0040001)3.57541606
45erythrocyte maturation (GO:0043249)3.56944520
46positive regulation of Cdc42 GTPase activity (GO:0043089)3.55530759
47regulation of histone H3-K27 methylation (GO:0061085)3.55068901
48negative thymic T cell selection (GO:0045060)3.54666936
49mitotic spindle assembly checkpoint (GO:0007094)3.54242831
50activation of Rac GTPase activity (GO:0032863)3.53441062
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.51302709
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.51220260
53negative regulation of sister chromatid segregation (GO:0033046)3.51220260
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.51220260
55negative regulation of mitotic sister chromatid segregation (GO:0033048)3.51220260
56negative T cell selection (GO:0043383)3.50914160
57response to laminar fluid shear stress (GO:0034616)3.45826160
58membrane disassembly (GO:0030397)3.44574394
59nuclear envelope disassembly (GO:0051081)3.44574394
60regulation of sister chromatid segregation (GO:0033045)3.43830371
61regulation of mitotic sister chromatid separation (GO:0010965)3.43830371
62regulation of mitotic sister chromatid segregation (GO:0033047)3.43830371
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.42706563
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40098260
65mitotic spindle checkpoint (GO:0071174)3.39835260
66positive regulation of gamma-delta T cell activation (GO:0046645)3.35353301
67DNA strand elongation involved in DNA replication (GO:0006271)3.34653150
68DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.34468210
69mitotic cytokinesis (GO:0000281)3.32985751
70CENP-A containing nucleosome assembly (GO:0034080)3.31191731
71regulation of sister chromatid cohesion (GO:0007063)3.29695481
72T cell selection (GO:0045058)3.29608871
73porphyrin-containing compound biosynthetic process (GO:0006779)3.25171166
74negative regulation of histone methylation (GO:0031061)3.23633083
75DNA replication-independent nucleosome organization (GO:0034724)3.19440947
76DNA replication-independent nucleosome assembly (GO:0006336)3.19440947
77DNA strand elongation (GO:0022616)3.16844611
78regulation of extracellular matrix disassembly (GO:0010715)3.15786873
79signal complex assembly (GO:0007172)3.15693003
80regulation of early endosome to late endosome transport (GO:2000641)3.14668427
81mitotic recombination (GO:0006312)3.14304138
82regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13745212
83chromatin remodeling at centromere (GO:0031055)3.13627460
84apoptotic process involved in morphogenesis (GO:0060561)3.13392889
85negative regulation of erythrocyte differentiation (GO:0045647)3.13191853
86COPI coating of Golgi vesicle (GO:0048205)3.13006618
87Golgi transport vesicle coating (GO:0048200)3.13006618
88telomere maintenance via semi-conservative replication (GO:0032201)3.12533261
89negative regulation of phagocytosis (GO:0050765)3.10782721
90heme biosynthetic process (GO:0006783)3.09257006
91chromatin assembly or disassembly (GO:0006333)3.09037308
92regulation of defense response to virus by virus (GO:0050690)3.08964064
93DNA damage response, signal transduction resulting in transcription (GO:0042772)3.07149867
94ATP-dependent chromatin remodeling (GO:0043044)3.01984455
95V(D)J recombination (GO:0033151)3.01581609
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98565740
97regulation of histone H3-K9 methylation (GO:0051570)2.97846168
98positive T cell selection (GO:0043368)2.97180875
99DNA packaging (GO:0006323)2.97100933
100negative regulation of cell size (GO:0045792)2.97066049
101DNA replication initiation (GO:0006270)2.96010961
102negative regulation of RNA splicing (GO:0033119)2.92857642
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.92799887
104NIK/NF-kappaB signaling (GO:0038061)2.91554308
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91132482
106regulation of T cell tolerance induction (GO:0002664)2.88984194
107regulation of centrosome cycle (GO:0046605)2.85786175
108telomere maintenance via recombination (GO:0000722)2.85160245
109cytoskeleton-dependent cytokinesis (GO:0061640)2.84640846
110regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84492267
111protein localization to endosome (GO:0036010)2.83921276
1123-UTR-mediated mRNA stabilization (GO:0070935)2.82671094
113modulation by virus of host process (GO:0019054)2.82307948
114mitotic sister chromatid cohesion (GO:0007064)2.80752866
115modulation by symbiont of host cellular process (GO:0044068)2.80069670
116histone-serine phosphorylation (GO:0035404)2.79093067
117nuclear envelope organization (GO:0006998)2.78389715
118antigen processing and presentation via MHC class Ib (GO:0002475)2.76012553
119focal adhesion assembly (GO:0048041)2.75240320
120cell-substrate adherens junction assembly (GO:0007045)2.75240320
121regulation of telomere maintenance via telomerase (GO:0032210)2.73660617
122tetrapyrrole biosynthetic process (GO:0033014)2.73623028
123cytokinetic process (GO:0032506)2.71713285
124DNA replication checkpoint (GO:0000076)2.71538208
125DNA replication-dependent nucleosome assembly (GO:0006335)2.71189581
126DNA replication-dependent nucleosome organization (GO:0034723)2.71189581
127histone exchange (GO:0043486)2.69706879
128B cell receptor signaling pathway (GO:0050853)2.68739296
129regulation of chromatin binding (GO:0035561)2.68631947
130DNA conformation change (GO:0071103)2.66720705
131cellular response to interleukin-4 (GO:0071353)2.66622476
132DNA geometric change (GO:0032392)2.66026375
133protein-DNA complex disassembly (GO:0032986)2.65397474
134nucleosome disassembly (GO:0006337)2.65397474
135positive regulation of keratinocyte differentiation (GO:0045618)2.64961213
136positive thymic T cell selection (GO:0045059)2.64585866
137chromatin assembly (GO:0031497)2.64453799
138DNA duplex unwinding (GO:0032508)2.64285406
139erythrocyte development (GO:0048821)2.64100065
140* mitotic cell cycle (GO:0000278)2.63865615
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.63440592
142negative regulation of chromosome organization (GO:2001251)2.62413428
143mannose metabolic process (GO:0006013)2.60193886
144adherens junction assembly (GO:0034333)2.59590521
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59212069
146intracellular estrogen receptor signaling pathway (GO:0030520)2.57636741
147cellular response to virus (GO:0098586)2.56808462
148pentose-phosphate shunt (GO:0006098)2.51066864
149regulation of NFAT protein import into nucleus (GO:0051532)2.49268332
150barbed-end actin filament capping (GO:0051016)2.49071615
151positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.45548611
152negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43841154
153regulation of B cell receptor signaling pathway (GO:0050855)2.43728053
154cellular response to epidermal growth factor stimulus (GO:0071364)2.42674467
155regulation of gamma-delta T cell differentiation (GO:0045586)2.42030782
156response to interleukin-4 (GO:0070670)2.37825210
157response to interleukin-15 (GO:0070672)2.37206438
158negative regulation of viral release from host cell (GO:1902187)2.37155388
159positive regulation of histone deacetylation (GO:0031065)2.36037573
160maternal placenta development (GO:0001893)2.35931053
161embryonic process involved in female pregnancy (GO:0060136)2.34488008
162modulation by symbiont of host immune response (GO:0052553)2.34275663
163positive regulation by symbiont of host defense response (GO:0052509)2.34275663
164modulation by symbiont of host defense response (GO:0052031)2.34275663
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34275663
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34275663
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.34275663
168retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32349294
169negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31694072
170regulation of gamma-delta T cell activation (GO:0046643)2.31633073
171modulation by virus of host morphology or physiology (GO:0019048)2.31127561
172negative regulation of necroptotic process (GO:0060546)2.31005113
173positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.29729745
174tolerance induction (GO:0002507)2.29177367
175T cell migration (GO:0072678)2.28172810
176cell-substrate junction assembly (GO:0007044)2.27221577
177response to muramyl dipeptide (GO:0032495)2.26656625
178regulation of necroptotic process (GO:0060544)2.25928165
179positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.24631309
180glucose 6-phosphate metabolic process (GO:0051156)2.24450108
181protein retention in ER lumen (GO:0006621)2.20164461
182activation of JUN kinase activity (GO:0007257)2.19453867
183hepatocyte apoptotic process (GO:0097284)2.18507552
184negative regulation of skeletal muscle tissue development (GO:0048642)2.13994297
185stress fiber assembly (GO:0043149)2.13621964
186regulation of extracellular matrix organization (GO:1903053)2.12725200
187histone phosphorylation (GO:0016572)2.12637734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human9.33926043
2E2F7_22180533_ChIP-Seq_HELA_Human9.10327379
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.57954149
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21822546
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56946966
6MYC_22102868_ChIP-Seq_BL_Human3.29376955
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.98287496
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.61973174
9VDR_21846776_ChIP-Seq_THP-1_Human2.48758820
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41072962
11LXR_22292898_ChIP-Seq_THP-1_Human2.25474910
12CIITA_25753668_ChIP-Seq_RAJI_Human2.13630402
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.10599603
14AR_21909140_ChIP-Seq_LNCAP_Human2.06456929
15RACK7_27058665_Chip-Seq_MCF-7_Human1.98416794
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98187764
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.95844804
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95810319
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95069507
20* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93163462
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77169981
22XRN2_22483619_ChIP-Seq_HELA_Human1.74731795
23SCL_19346495_ChIP-Seq_HPC-7_Human1.73730248
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71437273
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70459402
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64302032
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63494184
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63022044
29MAF_26560356_Chip-Seq_TH1_Human1.61121238
30UTX_26944678_Chip-Seq_JUKART_Human1.60785894
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60478997
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60053324
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57940025
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54903535
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52528720
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50568317
37MYB_26560356_Chip-Seq_TH2_Human1.49670506
38TCF7_22412390_ChIP-Seq_EML_Mouse1.49287081
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46887073
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43977966
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40606791
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.39142763
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37566224
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37405412
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36204524
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36092061
47ZNF263_19887448_ChIP-Seq_K562_Human1.35551710
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33956122
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33441876
50* KDM2B_26808549_Chip-Seq_DND41_Human1.33093583
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32955900
52KDM2B_26808549_Chip-Seq_K562_Human1.32515833
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32279068
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31486005
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30734692
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30601296
57FOXP3_21729870_ChIP-Seq_TREG_Human1.30497412
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.30100496
59MYB_26560356_Chip-Seq_TH1_Human1.29824516
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29422947
61* P68_20966046_ChIP-Seq_HELA_Human1.29279200
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28936243
63VDR_24763502_ChIP-Seq_THP-1_Human1.26875038
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.26034052
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25926158
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24846260
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.24678881
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.23218264
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22716363
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22676817
71VDR_23849224_ChIP-Seq_CD4+_Human1.22067123
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21879407
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21587766
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21394261
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21214545
76GATA1_19941826_ChIP-Seq_K562_Human1.19889368
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19576996
78* ATF3_27146783_Chip-Seq_COLON_Human1.19231351
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18048769
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.16924047
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16751811
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16238851
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16047625
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.15667177
85* MAF_26560356_Chip-Seq_TH2_Human1.15642761
86SMC4_20622854_ChIP-Seq_HELA_Human1.15269167
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15197514
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14894087
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14054690
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14009625
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13738668
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13698974
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13556953
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13302750
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12882457
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12561350
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08549714
98DCP1A_22483619_ChIP-Seq_HELA_Human1.08403824
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07499162
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.07103347
101SPI1_23547873_ChIP-Seq_NB4_Human1.06085797
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05698227
103CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05542927
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05536880
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05084470
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.03774353
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03075279
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02261886
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02128813
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01765289
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.00529665
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00079873
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99850308
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99756570
115TTF2_22483619_ChIP-Seq_HELA_Human0.99328040
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98739130
117CREB1_26743006_Chip-Seq_LNCaP_Human0.98502338
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98167364
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.97384034
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97138552
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96112949
122* BCOR_27268052_Chip-Seq_Bcells_Human0.96043977
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.96038788
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.95831836
125GABP_19822575_ChIP-Seq_HepG2_Human0.95736627
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95004910
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94813795
128NCOR1_26117541_ChIP-Seq_K562_Human0.94572926
129* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93537898
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93242584
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90754221
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89435661
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88420255
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88125485
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87660498
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86476954
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86169447
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85933095
139E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84794053
140RUNX_20019798_ChIP-Seq_JUKART_Human0.83965773
141* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82599344
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.82059766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.61722935
2MP0003693_abnormal_embryo_hatching4.02073814
3MP0010094_abnormal_chromosome_stability3.76461892
4MP0003077_abnormal_cell_cycle3.72464976
5MP0003656_abnormal_erythrocyte_physiolo3.50983388
6MP0004957_abnormal_blastocyst_morpholog2.86819090
7MP0004147_increased_porphyrin_level2.83874478
8MP0002877_abnormal_melanocyte_morpholog2.71495997
9MP0005451_abnormal_body_composition2.55281096
10MP0008260_abnormal_autophagy2.55248332
11MP0000685_abnormal_immune_system2.43963401
12MP0002396_abnormal_hematopoietic_system2.24190387
13MP0004808_abnormal_hematopoietic_stem2.22067439
14MP0005076_abnormal_cell_differentiation2.20515130
15MP0002398_abnormal_bone_marrow2.19141831
16MP0000569_abnormal_digit_pigmentation2.08363826
17MP0005058_abnormal_lysosome_morphology2.07565340
18MP0004381_abnormal_hair_follicle2.01318892
19MP0003763_abnormal_thymus_physiology2.01205448
20MP0003191_abnormal_cellular_cholesterol1.99910955
21MP0008057_abnormal_DNA_replication1.99880266
22MP0005671_abnormal_response_to1.99863376
23MP0008438_abnormal_cutaneous_collagen1.99863074
24MP0000703_abnormal_thymus_morphology1.96872122
25MP0004185_abnormal_adipocyte_glucose1.94725751
26MP0000350_abnormal_cell_proliferation1.94278881
27MP0008961_abnormal_basal_metabolism1.93118495
28MP0001800_abnormal_humoral_immune1.90889596
29MP0008007_abnormal_cellular_replicative1.89984651
30MP0002722_abnormal_immune_system1.85799805
31MP0001730_embryonic_growth_arrest1.84856731
32MP0001348_abnormal_lacrimal_gland1.83306580
33MP0000490_abnormal_crypts_of1.82061885
34MP0000689_abnormal_spleen_morphology1.80868257
35MP0010307_abnormal_tumor_latency1.80336221
36MP0008058_abnormal_DNA_repair1.79855794
37MP0009278_abnormal_bone_marrow1.71139921
38MP0010030_abnormal_orbit_morphology1.70736472
39MP0005397_hematopoietic_system_phenotyp1.64820987
40MP0001545_abnormal_hematopoietic_system1.64820987
41MP0003453_abnormal_keratinocyte_physiol1.62952822
42MP0003091_abnormal_cell_migration1.62105232
43MP0006054_spinal_hemorrhage1.59513625
44MP0010352_gastrointestinal_tract_polyps1.57457016
45MP0002429_abnormal_blood_cell1.56642687
46MP0002019_abnormal_tumor_incidence1.55567303
47MP0004858_abnormal_nervous_system1.55425362
48MP0008932_abnormal_embryonic_tissue1.54884131
49MP0009333_abnormal_splenocyte_physiolog1.53727397
50MP0000716_abnormal_immune_system1.53697694
51MP0003300_gastrointestinal_ulcer1.50071653
52MP0002420_abnormal_adaptive_immunity1.49688280
53MP0001819_abnormal_immune_cell1.45898572
54MP0002452_abnormal_antigen_presenting1.45082529
55MP0001835_abnormal_antigen_presentation1.39630249
56MP0003705_abnormal_hypodermis_morpholog1.38153865
57MP0003172_abnormal_lysosome_physiology1.34615787
58MP0003123_paternal_imprinting1.34543347
59MP0005387_immune_system_phenotype1.34494671
60MP0001790_abnormal_immune_system1.34494671
61MP0002796_impaired_skin_barrier1.34470475
62MP0003303_peritoneal_inflammation1.33752763
63MP0005409_darkened_coat_color1.29292000
64MP0000678_abnormal_parathyroid_gland1.29134157
65MP0000313_abnormal_cell_death1.28865525
66MP0000733_abnormal_muscle_development1.25105832
67MP0002080_prenatal_lethality1.24706664
68MP0002095_abnormal_skin_pigmentation1.24626354
69MP0010234_abnormal_vibrissa_follicle1.24207884
70MP0001697_abnormal_embryo_size1.22876383
71MP0002060_abnormal_skin_morphology1.21512825
72MP0005380_embryogenesis_phenotype1.20767041
73MP0001672_abnormal_embryogenesis/_devel1.20767041
74MP0002723_abnormal_immune_serum1.20640027
75MP0001873_stomach_inflammation1.19662379
76MP0003866_abnormal_defecation1.19591117
77MP0001958_emphysema1.19113978
78MP0002085_abnormal_embryonic_tissue1.17900774
79MP0009840_abnormal_foam_cell1.13930718
80MP0002419_abnormal_innate_immunity1.13826092
81MP0002653_abnormal_ependyma_morphology1.13597568
82MP0002405_respiratory_system_inflammati1.13195039
83MP0005000_abnormal_immune_tolerance1.12717364
84MP0005623_abnormal_meninges_morphology1.11749902
85MP0005257_abnormal_intraocular_pressure1.09575756
86MP0000015_abnormal_ear_pigmentation1.09156672
87MP0004233_abnormal_muscle_weight1.08714215
88MP0003984_embryonic_growth_retardation1.07846426
89MP0005464_abnormal_platelet_physiology1.06749835
90MP0002088_abnormal_embryonic_growth/wei1.06403189
91MP0002086_abnormal_extraembryonic_tissu1.05524276
92MP0002166_altered_tumor_susceptibility1.05093208
93MP0002249_abnormal_larynx_morphology1.04824461
94MP0001851_eye_inflammation1.04058211
95MP0001853_heart_inflammation1.01934212
96MP0003436_decreased_susceptibility_to1.01601716
97MP0001533_abnormal_skeleton_physiology1.00855691
98MP0010155_abnormal_intestine_physiology0.98814841
99MP0003787_abnormal_imprinting0.97472019
100MP0002084_abnormal_developmental_patter0.96986338
101MP0003279_aneurysm0.96433305
102MP0000858_altered_metastatic_potential0.96401249
103MP0004947_skin_inflammation0.95331080
104MP0004197_abnormal_fetal_growth/weight/0.92970113
105MP0005501_abnormal_skin_physiology0.91879444
106MP0005023_abnormal_wound_healing0.90748799
107MP0000465_gastrointestinal_hemorrhage0.89576526
108MP0003121_genomic_imprinting0.86189076
109MP0002751_abnormal_autonomic_nervous0.86121348
110MP0002998_abnormal_bone_remodeling0.86051262
111MP0002009_preneoplasia0.85617228
112MP0003890_abnormal_embryonic-extraembry0.85603952
113MP0004133_heterotaxia0.85300456
114MP0001216_abnormal_epidermal_layer0.84837930
115MP0002089_abnormal_postnatal_growth/wei0.84709728
116MP0000767_abnormal_smooth_muscle0.84158480
117MP0005621_abnormal_cell_physiology0.83956332
118MP0001243_abnormal_dermal_layer0.82832769
119MP0008789_abnormal_olfactory_epithelium0.82397868
120MP0005666_abnormal_adipose_tissue0.82019290
121MP0003448_altered_tumor_morphology0.81420031
122MP0003115_abnormal_respiratory_system0.81254112
123MP0003786_premature_aging0.80226017
124MP0005025_abnormal_response_to0.79824311
125MP0008770_decreased_survivor_rate0.79265924
126MP0002933_joint_inflammation0.78389765
127MP0002282_abnormal_trachea_morphology0.77920239
128MP0002006_tumorigenesis0.76738415
129MP0005174_abnormal_tail_pigmentation0.74674773
130MP0008877_abnormal_DNA_methylation0.74047991
131MP0001849_ear_inflammation0.73225977
132MP0004264_abnormal_extraembryonic_tissu0.72722411
133MP0003315_abnormal_perineum_morphology0.71844684
134MP0000566_synostosis0.71826030
135MP0009931_abnormal_skin_appearance0.71811501
136MP0003183_abnormal_peptide_metabolism0.70568901
137MP0003566_abnormal_cell_adhesion0.70479024
138MP0005384_cellular_phenotype0.69984215
139MP0002932_abnormal_joint_morphology0.68892735
140MP0000477_abnormal_intestine_morphology0.65581644

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.05930933
2Poikilocytosis (HP:0004447)4.74933125
3Hypochromic microcytic anemia (HP:0004840)3.50373774
4Verrucae (HP:0200043)3.50275341
5Papilloma (HP:0012740)3.50275341
6Cellulitis (HP:0100658)3.34113757
7Agammaglobulinemia (HP:0004432)3.31331816
8Reticulocytosis (HP:0001923)3.23278189
9Broad face (HP:0000283)3.20232403
10Eczematoid dermatitis (HP:0000976)3.16560705
11Hypochromic anemia (HP:0001931)3.08008782
12Acanthocytosis (HP:0001927)3.07416794
13Abnormality of the fingertips (HP:0001211)3.03487122
14Abnormality of the intervertebral disk (HP:0005108)2.95551572
15Protrusio acetabuli (HP:0003179)2.92555440
16Abnormality of cells of the erythroid lineage (HP:0012130)2.87748488
17Combined immunodeficiency (HP:0005387)2.85442433
18Abnormality of reticulocytes (HP:0004312)2.84556610
19Vertebral compression fractures (HP:0002953)2.78299913
20Premature rupture of membranes (HP:0001788)2.76070311
21Basal cell carcinoma (HP:0002671)2.71461113
22Obstructive sleep apnea (HP:0002870)2.70471116
23Recurrent bronchitis (HP:0002837)2.67650714
24Increased nuchal translucency (HP:0010880)2.67117286
25Abnormal number of erythroid precursors (HP:0012131)2.63589766
26Volvulus (HP:0002580)2.58778906
27Patellar aplasia (HP:0006443)2.58758446
28Cerebral aneurysm (HP:0004944)2.57035998
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.56292854
30T lymphocytopenia (HP:0005403)2.55541067
31Recurrent viral infections (HP:0004429)2.53075229
32Short middle phalanx of the 5th finger (HP:0004220)2.51087142
33Insomnia (HP:0100785)2.49405386
34B lymphocytopenia (HP:0010976)2.48063452
35Abnormality of B cell number (HP:0010975)2.48063452
36Thyroiditis (HP:0100646)2.45995801
37Increased connective tissue (HP:0009025)2.39844787
38Dislocated radial head (HP:0003083)2.39650891
39Abnormality of chromosome segregation (HP:0002916)2.39562883
40Abnormality of T cell number (HP:0011839)2.38595147
41IgM deficiency (HP:0002850)2.36434861
42Panhypogammaglobulinemia (HP:0003139)2.35226653
43Aplasia/Hypoplasia of the patella (HP:0006498)2.35129266
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31743134
45Mitral regurgitation (HP:0001653)2.31203894
46Severe combined immunodeficiency (HP:0004430)2.29737633
47Long palpebral fissure (HP:0000637)2.28772499
48Pustule (HP:0200039)2.28175161
49Chromsome breakage (HP:0040012)2.27841664
50Abnormality of the radial head (HP:0003995)2.25661139
51Micronodular cirrhosis (HP:0001413)2.25433404
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25279575
53Short 4th metacarpal (HP:0010044)2.25279575
54Ulnar bowing (HP:0003031)2.25111704
55Hyperacusis (HP:0010780)2.20676353
56Subacute progressive viral hepatitis (HP:0006572)2.18936036
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.17833228
58Disproportionate tall stature (HP:0001519)2.17814066
59Ankle contracture (HP:0006466)2.17110039
60Increased IgE level (HP:0003212)2.16803982
61Achilles tendon contracture (HP:0001771)2.15807127
62Reticulocytopenia (HP:0001896)2.15718246
63Cafe-au-lait spot (HP:0000957)2.15077376
64Chronic otitis media (HP:0000389)2.13323164
65Abnormality of macrophages (HP:0004311)2.12369267
66Small epiphyses (HP:0010585)2.12273574
67Thin bony cortex (HP:0002753)2.11648332
68Recurrent abscess formation (HP:0002722)2.10927268
69Trismus (HP:0000211)2.10199638
70Myelodysplasia (HP:0002863)2.09657265
71Long eyelashes (HP:0000527)2.09387444
72Ectopic kidney (HP:0000086)2.09146476
73Fragile skin (HP:0001030)2.09128212
74Distal lower limb amyotrophy (HP:0008944)2.08381972
75Duodenal stenosis (HP:0100867)2.06790030
76Small intestinal stenosis (HP:0012848)2.06790030
77Heterotopia (HP:0002282)2.05874462
78High pitched voice (HP:0001620)2.05633871
79Spinal cord lesions (HP:0100561)2.05484719
80Syringomyelia (HP:0003396)2.05484719
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04744375
82Cervical subluxation (HP:0003308)2.01983986
83Slow saccadic eye movements (HP:0000514)2.01568163
84Paralysis (HP:0003470)2.01449235
85Vertebral arch anomaly (HP:0008438)2.01310865
86Ependymoma (HP:0002888)2.00654700
87Dilatation of the ascending aorta (HP:0005111)2.00246496
88Overlapping toe (HP:0001845)2.00101271
89Recurrent bacterial skin infections (HP:0005406)2.00092725
90Biconcave vertebral bodies (HP:0004586)1.99135507
91Meningitis (HP:0001287)1.98985642
92Shallow orbits (HP:0000586)1.98395807
93Increased density of long bones (HP:0006392)1.98151016
94Hypercortisolism (HP:0001578)1.97887444
95Colitis (HP:0002583)1.97872202
96Asymmetry of the thorax (HP:0001555)1.96588801
97Microcytic anemia (HP:0001935)1.95752502
98Birth length less than 3rd percentile (HP:0003561)1.95611714
99Distal lower limb muscle weakness (HP:0009053)1.95605340
100Cutis marmorata (HP:0000965)1.94133919
101Lymphoma (HP:0002665)1.93824463
102Generalized amyotrophy (HP:0003700)1.92951219
103Cutaneous photosensitivity (HP:0000992)1.92576037
104Distal upper limb amyotrophy (HP:0007149)1.92556324
105Upper limb amyotrophy (HP:0009129)1.92556324
106Easy fatigability (HP:0003388)1.92066242
107Abnormality of cells of the lymphoid lineage (HP:0012140)1.91676520
108Short 5th finger (HP:0009237)1.91255267
109Broad palm (HP:0001169)1.90429441
110Poikiloderma (HP:0001029)1.89080578
111Selective tooth agenesis (HP:0001592)1.88819436
112Abnormality of chromosome stability (HP:0003220)1.88638546
113Broad distal phalanx of finger (HP:0009836)1.88089465
114Recurrent sinusitis (HP:0011108)1.87838455
115Viral hepatitis (HP:0006562)1.87589282
116Abnormal number of incisors (HP:0011064)1.85872857
117Cutaneous melanoma (HP:0012056)1.85291464
118Lymphopenia (HP:0001888)1.83490976
119Abnormality of the Achilles tendon (HP:0005109)1.83292334
120Abnormality of T cells (HP:0002843)1.83291645
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82803102
122Absent epiphyses (HP:0010577)1.82803102
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.82713814
124Osteolytic defects of the hand bones (HP:0009699)1.82713814
125Aneurysm (HP:0002617)1.82532604
126Osteomyelitis (HP:0002754)1.80684111
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.79761863
128Abnormality of oral frenula (HP:0000190)1.79006131
129Petechiae (HP:0000967)1.78164396
130Deep palmar crease (HP:0006191)1.77936862
131Hyperparathyroidism (HP:0000843)1.77605472
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.77230182
133Medulloblastoma (HP:0002885)1.75813708
134Diaphragmatic weakness (HP:0009113)1.75571407
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.75195385
136Elbow flexion contracture (HP:0002987)1.74934252
137Gastrointestinal inflammation (HP:0004386)1.74909786
138Increased variability in muscle fiber diameter (HP:0003557)1.74200854
139Renal duplication (HP:0000075)1.74038222
14011 pairs of ribs (HP:0000878)1.73668795
141Proximal placement of thumb (HP:0009623)1.73575485
142Abnormality of the duodenum (HP:0002246)1.71383895
143Meckel diverticulum (HP:0002245)1.71350009
144IgG deficiency (HP:0004315)1.70596153
145Abnormality of the ileum (HP:0001549)1.70497817
146Inflammation of the large intestine (HP:0002037)1.69925673
147J-shaped sella turcica (HP:0002680)1.69765633
148Interstitial pulmonary disease (HP:0006530)1.69562824
149Blue sclerae (HP:0000592)1.69375290
150Prominent nose (HP:0000448)1.69339277
151Recurrent otitis media (HP:0000403)1.69247475
152Aplasia/Hypoplasia of the thymus (HP:0010515)1.69222718
153Pallor (HP:0000980)1.68807723
154Deviation of the thumb (HP:0009603)1.68337547
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68258810
156Abnormality of the distal phalanges of the toes (HP:0010182)1.68247748
157Fatigue (HP:0012378)1.67886556
158Emphysema (HP:0002097)1.67330156
159Entropion (HP:0000621)1.66920599
160Short nail (HP:0001799)1.66806576
161Abnormality of the phalanges of the hallux (HP:0010057)1.64731825
162Gastrointestinal dysmotility (HP:0002579)1.64603704
163Arterial tortuosity (HP:0005116)1.64599026
164Spinal rigidity (HP:0003306)1.64082904
165Growth hormone excess (HP:0000845)1.63867243
166Thin ribs (HP:0000883)1.63843393
167Pointed chin (HP:0000307)1.63588423
168Flat acetabular roof (HP:0003180)1.62789650
169Recurrent fungal infections (HP:0002841)1.62760921
170Abnormality of the distal phalanx of the thumb (HP:0009617)1.60997917
171Vascular tortuosity (HP:0004948)1.60505250
172Abnormality of the thoracic spine (HP:0100711)1.60478118
173Reduced subcutaneous adipose tissue (HP:0003758)1.59997626
174Premature skin wrinkling (HP:0100678)1.59219685
175Abnormality of the humeroradial joint (HP:0100744)1.58450149
176Elevated erythrocyte sedimentation rate (HP:0003565)1.57690014
177Myositis (HP:0100614)1.57521423
178Cholecystitis (HP:0001082)1.56860639
179Abnormal gallbladder physiology (HP:0012438)1.56860639
180Genu recurvatum (HP:0002816)1.56807765
181Gingivitis (HP:0000230)1.56779018
182Polygenic inheritance (HP:0010982)1.55968158
183Supranuclear gaze palsy (HP:0000605)1.54514236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63246907
2MAP3K104.03378850
3STK103.88040843
4PRPF4B3.66677992
5SMG13.37123821
6NEK23.36406270
7CDC73.28702956
8EEF2K3.13393983
9MAP4K12.99848047
10TRIB32.89859938
11CDK122.66771589
12BRSK22.42026997
13ICK2.29250023
14IRAK32.20882530
15EIF2AK12.16353680
16GRK61.99030081
17WEE11.86129142
18PKN21.84955581
19AURKB1.77487449
20EPHB11.74968917
21CDK41.69442476
22PLK11.65998099
23MST1R1.64735504
24UHMK11.63705617
25TTK1.63032764
26MAP3K81.61805992
27STK41.55770440
28EPHA21.55194234
29MAP3K131.47325761
30TESK11.46355292
31TLK11.42817152
32BRD41.41962149
33RPS6KA41.36621112
34RPS6KB21.35012555
35IRAK41.32732726
36LRRK21.30217605
37MARK31.29486594
38CCNB11.27580701
39SIK21.27502932
40* BRSK11.27133554
41RIPK11.26761082
42TAOK21.23511596
43CHEK21.22439239
44DYRK31.15510685
45SYK1.14528342
46ATR1.13560537
47ERN11.13498915
48CDK81.11473242
49CDK91.09811044
50MAP3K31.09622281
51* AURKA1.07572393
52PRKD21.05243443
53CDK61.03367678
54CLK11.00701375
55KSR20.99632498
56RIPK40.94693778
57TAOK10.94418976
58PTK20.92464645
59MARK20.91686160
60PRKD30.88646873
61PASK0.88500479
62CDK70.87848798
63PLK30.87728129
64* CHEK10.86625871
65DYRK1B0.85465035
66TESK20.84909406
67PIM10.84089781
68CSK0.83788843
69NEK10.83084612
70BTK0.82527700
71MAP3K10.79739074
72KSR10.79487520
73JAK30.78660429
74TNK20.78179280
75MAP3K110.77019888
76BRAF0.76508739
77* MELK0.76457907
78ITK0.75094826
79TBK10.74006080
80CSF1R0.73473112
81MAP2K20.72202141
82IRAK20.70489249
83LMTK20.70065078
84BLK0.68433774
85NME20.67974172
86MET0.66452110
87CAMKK10.66423119
88BMX0.66377956
89TYRO30.64839756
90SCYL20.64254993
91ZAP700.63821192
92ARAF0.62944091
93MOS0.62809965
94PDPK10.62664029
95STK380.62497908
96LYN0.62374537
97CDK20.60857489
98SIK30.60626716
99TYK20.59399600
100STK30.57800642
101JAK10.57512712
102MAP3K140.57026580
103FGFR40.56041014
104LIMK10.55809922
105ATM0.55506341
106MKNK10.55505994
107PAK10.55066041
108* CDK10.53085000
109MAPKAPK30.52450885
110TTN0.50302126
111TGFBR10.49666596
112PAK40.49091876
113SRPK10.48368931
114LCK0.48025971
115PDK10.46164420
116HCK0.44526349
117ILK0.44123025
118RPS6KL10.43840958
119RPS6KC10.43840958
120TRPM70.43694482
121* MAPKAPK20.42276166
122FGFR30.40554842
123FGFR20.40214348
124PDGFRB0.39654491
125AKT20.39437254
126CHUK0.38553304
127MAP3K70.38023958
128* MAPK110.37762037
129RPS6KA20.37759647
130FES0.37487593
131VRK10.37034849
132* CDC42BPA0.36800430
133SIK10.36439275
134MAP2K30.35942991
135PTK60.35076266
136NEK60.34839686
137IKBKE0.34652540
138MAP3K90.33566441
139HIPK20.33359004
140MTOR0.32834818
141PBK0.32146805
142ALK0.31295880
143RAF10.24793782
144PDGFRA0.23323090
145KIT0.21981616
146PRKCI0.21151284
147PRKCQ0.21108553
148PRKCH0.21044065
149PLK40.20858741
150RPS6KA50.20470419
151MKNK20.20448972

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.76272869
2* Cell cycle_Homo sapiens_hsa041103.39725163
3Base excision repair_Homo sapiens_hsa034103.19077609
4Mismatch repair_Homo sapiens_hsa034302.83175427
5Primary immunodeficiency_Homo sapiens_hsa053402.66529519
6Spliceosome_Homo sapiens_hsa030402.46580469
7Homologous recombination_Homo sapiens_hsa034402.09988845
8Systemic lupus erythematosus_Homo sapiens_hsa053221.98495391
9Non-homologous end-joining_Homo sapiens_hsa034501.97387884
10B cell receptor signaling pathway_Homo sapiens_hsa046621.96953882
11RNA transport_Homo sapiens_hsa030131.83475695
12Other glycan degradation_Homo sapiens_hsa005111.77672562
13p53 signaling pathway_Homo sapiens_hsa041151.76357368
14Fanconi anemia pathway_Homo sapiens_hsa034601.75763737
15Notch signaling pathway_Homo sapiens_hsa043301.73953436
16Nucleotide excision repair_Homo sapiens_hsa034201.73374509
17Chronic myeloid leukemia_Homo sapiens_hsa052201.68592514
18* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65727691
19Ribosome_Homo sapiens_hsa030101.57253864
20mRNA surveillance pathway_Homo sapiens_hsa030151.53088409
21Non-small cell lung cancer_Homo sapiens_hsa052231.51198680
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46943154
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44867899
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41911525
25Oocyte meiosis_Homo sapiens_hsa041141.39685243
26Pancreatic cancer_Homo sapiens_hsa052121.38517415
27Viral carcinogenesis_Homo sapiens_hsa052031.38194444
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35748271
29HTLV-I infection_Homo sapiens_hsa051661.35274454
30T cell receptor signaling pathway_Homo sapiens_hsa046601.34302974
31Herpes simplex infection_Homo sapiens_hsa051681.30321603
32Hepatitis B_Homo sapiens_hsa051611.29983038
33Small cell lung cancer_Homo sapiens_hsa052221.25026612
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.25021865
35* MicroRNAs in cancer_Homo sapiens_hsa052061.24863188
36Hematopoietic cell lineage_Homo sapiens_hsa046401.23216842
37Epstein-Barr virus infection_Homo sapiens_hsa051691.21579386
38Antigen processing and presentation_Homo sapiens_hsa046121.20524816
39Apoptosis_Homo sapiens_hsa042101.16254457
40Measles_Homo sapiens_hsa051621.15933239
41Colorectal cancer_Homo sapiens_hsa052101.14727238
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.11189514
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10019270
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09198126
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08689722
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08219644
47ErbB signaling pathway_Homo sapiens_hsa040121.07247149
48Alcoholism_Homo sapiens_hsa050341.06399606
49RNA degradation_Homo sapiens_hsa030181.03166961
50Inositol phosphate metabolism_Homo sapiens_hsa005621.02445567
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02388202
52Hepatitis C_Homo sapiens_hsa051601.01540083
53Bladder cancer_Homo sapiens_hsa052191.00589609
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00007030
55Prion diseases_Homo sapiens_hsa050200.98784986
56One carbon pool by folate_Homo sapiens_hsa006700.98420373
57Endocytosis_Homo sapiens_hsa041440.97920290
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97884759
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97662720
60TNF signaling pathway_Homo sapiens_hsa046680.94182809
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.92248939
62Leishmaniasis_Homo sapiens_hsa051400.92103864
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.90653903
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90290035
65Choline metabolism in cancer_Homo sapiens_hsa052310.88946319
66Pyrimidine metabolism_Homo sapiens_hsa002400.88603060
67Osteoclast differentiation_Homo sapiens_hsa043800.88547073
68Shigellosis_Homo sapiens_hsa051310.87190252
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87123470
70Glioma_Homo sapiens_hsa052140.87056499
71Insulin signaling pathway_Homo sapiens_hsa049100.86905855
72FoxO signaling pathway_Homo sapiens_hsa040680.86305308
73Acute myeloid leukemia_Homo sapiens_hsa052210.85516962
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84419082
75mTOR signaling pathway_Homo sapiens_hsa041500.84194517
76Focal adhesion_Homo sapiens_hsa045100.83302190
77VEGF signaling pathway_Homo sapiens_hsa043700.83282630
78Fructose and mannose metabolism_Homo sapiens_hsa000510.82035515
79Platelet activation_Homo sapiens_hsa046110.79305753
80Viral myocarditis_Homo sapiens_hsa054160.79106166
81Influenza A_Homo sapiens_hsa051640.77131983
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.75759931
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.73915608
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.73686595
85RNA polymerase_Homo sapiens_hsa030200.73001939
86Sulfur relay system_Homo sapiens_hsa041220.72475750
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70331377
88Vitamin B6 metabolism_Homo sapiens_hsa007500.70033127
89Prostate cancer_Homo sapiens_hsa052150.68994148
90Galactose metabolism_Homo sapiens_hsa000520.67243363
91Endometrial cancer_Homo sapiens_hsa052130.66825585
92GnRH signaling pathway_Homo sapiens_hsa049120.66672124
93Estrogen signaling pathway_Homo sapiens_hsa049150.65479261
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63824464
95Chemokine signaling pathway_Homo sapiens_hsa040620.63344473
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62286567
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61054024
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.58232744
99Toxoplasmosis_Homo sapiens_hsa051450.58087099
100Proteoglycans in cancer_Homo sapiens_hsa052050.58046894
101Lysine degradation_Homo sapiens_hsa003100.57751566
102Salmonella infection_Homo sapiens_hsa051320.57444761
103Insulin resistance_Homo sapiens_hsa049310.57328967
104Amoebiasis_Homo sapiens_hsa051460.57261383
105AMPK signaling pathway_Homo sapiens_hsa041520.56604136
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56463982
107Graft-versus-host disease_Homo sapiens_hsa053320.53145711
108Autoimmune thyroid disease_Homo sapiens_hsa053200.52765265
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51016847
110Long-term potentiation_Homo sapiens_hsa047200.50059528
111Renal cell carcinoma_Homo sapiens_hsa052110.49620608
112Pathways in cancer_Homo sapiens_hsa052000.49155043
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47144349
114Proteasome_Homo sapiens_hsa030500.46965847
115Thyroid cancer_Homo sapiens_hsa052160.46029441
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45735436
117Adherens junction_Homo sapiens_hsa045200.45382566
118HIF-1 signaling pathway_Homo sapiens_hsa040660.44933952
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.43709268
120Prolactin signaling pathway_Homo sapiens_hsa049170.43534533
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43040701
122Tuberculosis_Homo sapiens_hsa051520.42921408
123Basal cell carcinoma_Homo sapiens_hsa052170.41551095
124Malaria_Homo sapiens_hsa051440.40559355
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38708231
126Hippo signaling pathway_Homo sapiens_hsa043900.38487536
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38038907
128Pentose phosphate pathway_Homo sapiens_hsa000300.36208593
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35614399
130TGF-beta signaling pathway_Homo sapiens_hsa043500.35584679
131Dorso-ventral axis formation_Homo sapiens_hsa043200.35318346
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35245084

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