CDC25C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.16279036
2protein localization to kinetochore (GO:0034501)5.94768168
3kinetochore organization (GO:0051383)5.55485721
4metaphase plate congression (GO:0051310)5.42557895
5protein localization to chromosome, centromeric region (GO:0071459)5.36269564
6CENP-A containing nucleosome assembly (GO:0034080)5.19589012
7kinetochore assembly (GO:0051382)5.13979153
8establishment of chromosome localization (GO:0051303)5.10088709
9mitotic sister chromatid segregation (GO:0000070)5.07839019
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.05990952
11chromatin remodeling at centromere (GO:0031055)5.05823975
12attachment of spindle microtubules to kinetochore (GO:0008608)5.00570126
13regulation of spindle organization (GO:0090224)4.88782851
14mitotic chromosome condensation (GO:0007076)4.82907295
15sister chromatid segregation (GO:0000819)4.66069496
16DNA replication-independent nucleosome organization (GO:0034724)4.46071235
17DNA replication-independent nucleosome assembly (GO:0006336)4.46071235
18DNA replication checkpoint (GO:0000076)4.43534906
19spindle checkpoint (GO:0031577)4.42195960
20establishment of integrated proviral latency (GO:0075713)4.41942563
21histone exchange (GO:0043486)4.37556095
22meiotic chromosome segregation (GO:0045132)4.27830395
23mitotic nuclear envelope disassembly (GO:0007077)4.27450043
24regulation of mitotic spindle organization (GO:0060236)4.19071264
25nuclear pore organization (GO:0006999)4.15998410
26positive regulation of chromosome segregation (GO:0051984)4.14847154
27spindle assembly checkpoint (GO:0071173)4.05533544
28regulation of chromosome segregation (GO:0051983)4.05068583
29DNA strand elongation involved in DNA replication (GO:0006271)4.02289080
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.95240919
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.95240919
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.95240919
33microtubule depolymerization (GO:0007019)3.94963179
34nuclear envelope disassembly (GO:0051081)3.93499641
35membrane disassembly (GO:0030397)3.93499641
36negative regulation of chromosome segregation (GO:0051985)3.92923324
37nuclear pore complex assembly (GO:0051292)3.92622828
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.92084212
39negative regulation of sister chromatid segregation (GO:0033046)3.92084212
40negative regulation of mitotic sister chromatid separation (GO:2000816)3.92084212
41negative regulation of mitotic sister chromatid segregation (GO:0033048)3.92084212
42mitotic spindle checkpoint (GO:0071174)3.88120061
43regulation of mitotic metaphase/anaphase transition (GO:0030071)3.87919317
44mitotic sister chromatid cohesion (GO:0007064)3.87295134
45protein localization to chromosome (GO:0034502)3.86506294
46mitotic spindle assembly checkpoint (GO:0007094)3.86059808
47DNA strand elongation (GO:0022616)3.84596115
48chromosome segregation (GO:0007059)3.83048452
49DNA replication initiation (GO:0006270)3.82691841
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80983919
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.80215835
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.78842956
53telomere maintenance via semi-conservative replication (GO:0032201)3.77469871
54nucleobase biosynthetic process (GO:0046112)3.75798434
55regulation of mitotic sister chromatid separation (GO:0010965)3.73266396
56regulation of mitotic sister chromatid segregation (GO:0033047)3.73266396
57regulation of sister chromatid segregation (GO:0033045)3.73266396
58purine nucleobase biosynthetic process (GO:0009113)3.73212534
59regulation of centriole replication (GO:0046599)3.67978727
60mitotic recombination (GO:0006312)3.60475815
61telomere maintenance via recombination (GO:0000722)3.57915528
62ATP-dependent chromatin remodeling (GO:0043044)3.54161562
63maturation of SSU-rRNA (GO:0030490)3.53448644
64DNA unwinding involved in DNA replication (GO:0006268)3.51583645
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50315851
66replication fork processing (GO:0031297)3.45215162
67mitotic G2/M transition checkpoint (GO:0044818)3.42624409
68non-recombinational repair (GO:0000726)3.41228918
69double-strand break repair via nonhomologous end joining (GO:0006303)3.41228918
70DNA replication-dependent nucleosome assembly (GO:0006335)3.40968202
71DNA replication-dependent nucleosome organization (GO:0034723)3.40968202
72DNA topological change (GO:0006265)3.30860397
73chromatin assembly or disassembly (GO:0006333)3.30533000
74establishment of viral latency (GO:0019043)3.30133252
75regulation of centrosome cycle (GO:0046605)3.29668777
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.29376157
77ribosome biogenesis (GO:0042254)3.29334618
78chromosome condensation (GO:0030261)3.26580287
79DNA double-strand break processing (GO:0000729)3.26207548
80telomere maintenance via telomere lengthening (GO:0010833)3.25828236
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24898052
82IMP biosynthetic process (GO:0006188)3.24059814
83formation of translation preinitiation complex (GO:0001731)3.23462516
84regulation of DNA endoreduplication (GO:0032875)3.19917491
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18541904
86negative regulation of mitosis (GO:0045839)3.17936330
87histone-serine phosphorylation (GO:0035404)3.17874109
88spliceosomal snRNP assembly (GO:0000387)3.17827211
89microtubule polymerization or depolymerization (GO:0031109)3.16713749
90resolution of meiotic recombination intermediates (GO:0000712)3.15263860
91regulation of exit from mitosis (GO:0007096)3.14615774
92DNA ligation (GO:0006266)3.13410204
93* mitotic cell cycle (GO:0000278)3.12762100
94DNA strand renaturation (GO:0000733)3.12582648
95negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.11881712
96pore complex assembly (GO:0046931)3.09221272
97negative regulation of cell division (GO:0051782)3.08770204
98proteasome assembly (GO:0043248)3.07225034
99protein K6-linked ubiquitination (GO:0085020)3.06333119
100viral mRNA export from host cell nucleus (GO:0046784)3.05995268
101negative regulation of nuclear division (GO:0051784)3.05453663
102DNA conformation change (GO:0071103)3.05314319
103ventricular cardiac muscle cell development (GO:0055015)3.04883205
104maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02493481
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02004879
106DNA packaging (GO:0006323)3.01271643
107spliceosomal complex assembly (GO:0000245)3.00423507
108nuclear envelope organization (GO:0006998)2.99622436
109nucleotide-excision repair, DNA gap filling (GO:0006297)2.98352598
110maturation of 5.8S rRNA (GO:0000460)2.97942464
111ribosome assembly (GO:0042255)2.97103831
112regulation of mitotic spindle checkpoint (GO:1903504)2.95325899
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95325899
114regulation of telomere maintenance via telomerase (GO:0032210)2.93900209
115ribosomal small subunit assembly (GO:0000028)2.93334613
116ribonucleoprotein complex biogenesis (GO:0022613)2.89980918
117regulation of sister chromatid cohesion (GO:0007063)2.89575597
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89378640
119* mitotic nuclear division (GO:0007067)2.88208175
120transcription-coupled nucleotide-excision repair (GO:0006283)2.87992825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59732230
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.98652381
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61395911
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.49878933
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.98714214
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50945425
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11212812
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.00625245
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92668301
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86570786
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76936994
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76437391
13AR_21909140_ChIP-Seq_LNCAP_Human2.69517487
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66030599
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.63176476
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61933396
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.60989370
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51067998
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41365984
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38582862
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33080394
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29856485
23XRN2_22483619_ChIP-Seq_HELA_Human2.28824512
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19093841
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.18692425
26VDR_23849224_ChIP-Seq_CD4+_Human2.10526237
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06432970
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92733431
29DCP1A_22483619_ChIP-Seq_HELA_Human1.92334498
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92085679
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89988532
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89836938
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89408130
34ELK1_19687146_ChIP-ChIP_HELA_Human1.84321976
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81059363
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79828350
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79290487
38TTF2_22483619_ChIP-Seq_HELA_Human1.76448727
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.73412770
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72663658
41GABP_19822575_ChIP-Seq_HepG2_Human1.71844998
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.66675746
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63523779
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58366803
45CIITA_25753668_ChIP-Seq_RAJI_Human1.58274627
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57686743
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53526634
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50000706
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49368541
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47150062
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44358000
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.43861636
53KDM5A_27292631_Chip-Seq_BREAST_Human1.42544930
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41946888
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40206472
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.35118787
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35003110
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32552451
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29715011
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27256992
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25202347
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18640109
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14771017
64MYC_18940864_ChIP-ChIP_HL60_Human1.12665686
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07573046
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06939971
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04734318
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02753343
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02280037
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02191114
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01883354
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.01078578
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00156223
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99914951
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98002727
76STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97638456
77NANOG_21062744_ChIP-ChIP_HESCs_Human0.95448251
78MYC_22102868_ChIP-Seq_BL_Human0.94713243
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93761151
80* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92078559
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87481047
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87469835
83TFEB_21752829_ChIP-Seq_HELA_Human0.87373965
84EWS_26573619_Chip-Seq_HEK293_Human0.85429007
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85252362
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85166661
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83977418
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83855428
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81605500
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80770284
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80403573
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80166186
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.78533465
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77835959
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76475935
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.76430286
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74827927
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74679711
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.74349367
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.73777045
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.73069845
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71599200
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67379955
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66716006
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66205370
106* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65398053
107IRF1_19129219_ChIP-ChIP_H3396_Human0.64975226
108CHD1_26751641_Chip-Seq_LNCaP_Human0.64250824
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.63457520
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.63104995
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.63104995
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.63104995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62224781
2MP0003111_abnormal_nucleus_morphology5.11966965
3MP0010094_abnormal_chromosome_stability4.85624811
4MP0003077_abnormal_cell_cycle4.48000190
5MP0004957_abnormal_blastocyst_morpholog4.32375525
6MP0008057_abnormal_DNA_replication4.00686509
7MP0008058_abnormal_DNA_repair3.56830738
8MP0008007_abnormal_cellular_replicative3.41204101
9MP0003123_paternal_imprinting2.77508313
10MP0008932_abnormal_embryonic_tissue2.71664485
11MP0001730_embryonic_growth_arrest2.41389559
12MP0000350_abnormal_cell_proliferation2.24261896
13MP0008877_abnormal_DNA_methylation2.12443451
14MP0003786_premature_aging2.09515757
15MP0010030_abnormal_orbit_morphology2.01841459
16MP0002396_abnormal_hematopoietic_system1.97669854
17MP0005380_embryogenesis_phenotype1.87351581
18MP0001672_abnormal_embryogenesis/_devel1.87351581
19MP0010307_abnormal_tumor_latency1.84990237
20MP0001697_abnormal_embryo_size1.79237631
21MP0003941_abnormal_skin_development1.73678659
22MP0003718_maternal_effect1.73443657
23MP0003984_embryonic_growth_retardation1.65854761
24MP0002085_abnormal_embryonic_tissue1.62549827
25MP0002088_abnormal_embryonic_growth/wei1.61472281
26MP0003121_genomic_imprinting1.59418647
27MP0006292_abnormal_olfactory_placode1.54265172
28MP0002080_prenatal_lethality1.52842778
29MP0003315_abnormal_perineum_morphology1.49639527
30MP0003136_yellow_coat_color1.48692803
31MP0000313_abnormal_cell_death1.39421792
32MP0002084_abnormal_developmental_patter1.39067838
33MP0002086_abnormal_extraembryonic_tissu1.36862082
34MP0005076_abnormal_cell_differentiation1.35580130
35MP0002210_abnormal_sex_determination1.34922458
36MP0004808_abnormal_hematopoietic_stem1.33633687
37MP0001293_anophthalmia1.32570483
38MP0009053_abnormal_anal_canal1.31127323
39MP0010352_gastrointestinal_tract_polyps1.28928811
40MP0003890_abnormal_embryonic-extraembry1.28837289
41MP0004197_abnormal_fetal_growth/weight/1.28382784
42MP0000566_synostosis1.26579046
43MP0003567_abnormal_fetal_cardiomyocyte1.23424823
44MP0008789_abnormal_olfactory_epithelium1.22849297
45MP0003937_abnormal_limbs/digits/tail_de1.22783778
46MP0000490_abnormal_crypts_of1.21380587
47MP0002019_abnormal_tumor_incidence1.16337863
48MP0001929_abnormal_gametogenesis1.15456989
49MP0001145_abnormal_male_reproductive1.12514797
50MP0001346_abnormal_lacrimal_gland1.11124235
51MP0006035_abnormal_mitochondrial_morpho1.08214667
52MP0002938_white_spotting1.08051321
53MP0002233_abnormal_nose_morphology1.07177108
54MP0001119_abnormal_female_reproductive1.06645694
55MP0002132_abnormal_respiratory_system1.06472212
56MP0000653_abnormal_sex_gland1.02399633
57MP0009672_abnormal_birth_weight0.98243665
58MP0005394_taste/olfaction_phenotype0.97040339
59MP0005499_abnormal_olfactory_system0.97040339
60MP0005408_hypopigmentation0.97015539
61MP0003119_abnormal_digestive_system0.94804782
62MP0002234_abnormal_pharynx_morphology0.94320734
63MP0001529_abnormal_vocalization0.93592052
64MP0000358_abnormal_cell_content/0.92575817
65MP0005395_other_phenotype0.91218187
66MP0008995_early_reproductive_senescence0.91160577
67MP0000537_abnormal_urethra_morphology0.90918236
68MP0002160_abnormal_reproductive_system0.89508080
69MP0006072_abnormal_retinal_apoptosis0.89443563
70MP0003806_abnormal_nucleotide_metabolis0.88684089
71MP0003115_abnormal_respiratory_system0.87938780
72MP0002102_abnormal_ear_morphology0.86704630
73MP0000372_irregular_coat_pigmentation0.83358374
74MP0002111_abnormal_tail_morphology0.82161676
75MP0001286_abnormal_eye_development0.81493607
76MP0000703_abnormal_thymus_morphology0.80874252
77MP0005389_reproductive_system_phenotype0.78889548
78MP0003186_abnormal_redox_activity0.76237856
79MP0006036_abnormal_mitochondrial_physio0.75281487
80MP0001545_abnormal_hematopoietic_system0.74002932
81MP0005397_hematopoietic_system_phenotyp0.74002932
82MP0003385_abnormal_body_wall0.73883463
83MP0003938_abnormal_ear_development0.73131280
84MP0000647_abnormal_sebaceous_gland0.72897380
85MP0000428_abnormal_craniofacial_morphol0.72033825
86MP0004133_heterotaxia0.70983941
87MP0009333_abnormal_splenocyte_physiolog0.70780770
88MP0002653_abnormal_ependyma_morphology0.70144912
89MP0009703_decreased_birth_body0.69686821
90MP0005391_vision/eye_phenotype0.69300999
91MP0000432_abnormal_head_morphology0.68884694
92MP0000858_altered_metastatic_potential0.68646632
93MP0005384_cellular_phenotype0.68039132
94MP0005621_abnormal_cell_physiology0.66597573
95MP0003942_abnormal_urinary_system0.64878977
96MP0003221_abnormal_cardiomyocyte_apopto0.64611073
97MP0003935_abnormal_craniofacial_develop0.64332913
98MP0003699_abnormal_female_reproductive0.63748526
99MP0002398_abnormal_bone_marrow0.63742486
100MP0003755_abnormal_palate_morphology0.62264530
101MP0002722_abnormal_immune_system0.62049546
102MP0009697_abnormal_copulation0.61901509
103MP0005367_renal/urinary_system_phenotyp0.61887716
104MP0000516_abnormal_urinary_system0.61887716
105MP0002092_abnormal_eye_morphology0.61667198
106MP0003698_abnormal_male_reproductive0.61633592
107MP0000049_abnormal_middle_ear0.61610675
108MP0001849_ear_inflammation0.60709473
109MP0002161_abnormal_fertility/fecundity0.59645378
110MP0000579_abnormal_nail_morphology0.59639570
111MP0001727_abnormal_embryo_implantation0.58792174
112MP0003943_abnormal_hepatobiliary_system0.58502530
113MP0004147_increased_porphyrin_level0.58031775
114MP0003950_abnormal_plasma_membrane0.57703830
115MP0002282_abnormal_trachea_morphology0.56694897
116MP0000689_abnormal_spleen_morphology0.55702107
117MP0003861_abnormal_nervous_system0.54172038
118MP0001919_abnormal_reproductive_system0.54085434
119MP0002751_abnormal_autonomic_nervous0.53743379
120MP0005623_abnormal_meninges_morphology0.53735990
121MP0002697_abnormal_eye_size0.52345175
122MP0004084_abnormal_cardiac_muscle0.51755349
123MP0002932_abnormal_joint_morphology0.51577277
124MP0002114_abnormal_axial_skeleton0.51058306

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.34938721
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.31108672
3Birth length less than 3rd percentile (HP:0003561)4.35550829
4Meckel diverticulum (HP:0002245)3.87095367
5Patellar aplasia (HP:0006443)3.84546555
6Abnormal lung lobation (HP:0002101)3.82242967
7Breast hypoplasia (HP:0003187)3.80730263
8Impulsivity (HP:0100710)3.77280245
9Reticulocytopenia (HP:0001896)3.72743328
10Abnormality of chromosome stability (HP:0003220)3.70229664
11Carpal bone hypoplasia (HP:0001498)3.69917927
12Aplasia/Hypoplasia of the patella (HP:0006498)3.65575356
13Abnormality of the ileum (HP:0001549)3.64291579
14Abnormality of the preputium (HP:0100587)3.52013642
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.51087458
16Small intestinal stenosis (HP:0012848)3.41789761
17Duodenal stenosis (HP:0100867)3.41789761
18Ectopic kidney (HP:0000086)3.15058859
19Cortical dysplasia (HP:0002539)3.13560817
20Duplicated collecting system (HP:0000081)3.11620654
21Absent radius (HP:0003974)3.11149676
22Oral leukoplakia (HP:0002745)3.01710943
23Colon cancer (HP:0003003)3.00114833
24Abnormality of the renal collecting system (HP:0004742)2.90180772
25Absent forearm bone (HP:0003953)2.89072385
26Aplasia involving forearm bones (HP:0009822)2.89072385
27Myelodysplasia (HP:0002863)2.82310259
28Sloping forehead (HP:0000340)2.81623192
29Abnormality of the duodenum (HP:0002246)2.78569634
30Nephroblastoma (Wilms tumor) (HP:0002667)2.76363963
31Abnormality of the labia minora (HP:0012880)2.75998292
3211 pairs of ribs (HP:0000878)2.73794558
33Absent thumb (HP:0009777)2.73378958
34Horseshoe kidney (HP:0000085)2.72603460
35Medulloblastoma (HP:0002885)2.69433011
36Bone marrow hypocellularity (HP:0005528)2.66433314
37Selective tooth agenesis (HP:0001592)2.62749902
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62449582
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.60583705
40Degeneration of anterior horn cells (HP:0002398)2.58698069
41Abnormality of the anterior horn cell (HP:0006802)2.58698069
42Embryonal renal neoplasm (HP:0011794)2.57121890
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54874101
44Rough bone trabeculation (HP:0100670)2.45787405
45Supernumerary spleens (HP:0009799)2.43359731
46Hypoplastic pelvis (HP:0008839)2.42590930
47Triphalangeal thumb (HP:0001199)2.35618962
48Clubbing of toes (HP:0100760)2.35079148
49Abnormality of the carotid arteries (HP:0005344)2.33814259
50Aplastic anemia (HP:0001915)2.31769373
51Abnormality of cochlea (HP:0000375)2.30505878
52Increased nuchal translucency (HP:0010880)2.30153809
53Abnormality of DNA repair (HP:0003254)2.30118499
54Multiple enchondromatosis (HP:0005701)2.25964777
55Tracheoesophageal fistula (HP:0002575)2.24622130
56Short thumb (HP:0009778)2.22628821
57Choanal atresia (HP:0000453)2.19126654
58Abnormal number of erythroid precursors (HP:0012131)2.17500701
59Ependymoma (HP:0002888)2.17421772
60Premature graying of hair (HP:0002216)2.16719286
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16638848
62Short 4th metacarpal (HP:0010044)2.16638848
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.14869390
64Cellular immunodeficiency (HP:0005374)2.14840006
65Abnormality of cells of the erythroid lineage (HP:0012130)2.14418953
66Septo-optic dysplasia (HP:0100842)2.13951695
67Neoplasm of the pancreas (HP:0002894)2.13769460
68Atresia of the external auditory canal (HP:0000413)2.13745222
69Ureteral duplication (HP:0000073)2.13401232
70Increased hepatocellular lipid droplets (HP:0006565)2.13384042
71Embryonal neoplasm (HP:0002898)2.12869115
72Absent septum pellucidum (HP:0001331)2.12301918
73Abnormality of the septum pellucidum (HP:0007375)2.11315468
74Rhabdomyosarcoma (HP:0002859)2.10545805
75Cleft eyelid (HP:0000625)2.09936254
76Short middle phalanx of the 5th finger (HP:0004220)2.09497375
77Abnormality of glycolysis (HP:0004366)2.09258702
78Increased serum pyruvate (HP:0003542)2.06709563
79Abnormal number of incisors (HP:0011064)2.03650302
80Cafe-au-lait spot (HP:0000957)2.03483918
81Duplication of thumb phalanx (HP:0009942)2.02385246
82Overlapping toe (HP:0001845)1.98587368
83Cerebral hypomyelination (HP:0006808)1.96808484
84Facial cleft (HP:0002006)1.96008716
85Broad distal phalanx of finger (HP:0009836)1.94712368
86Abnormality of pyrimidine metabolism (HP:0004353)1.94195639
87Facial hemangioma (HP:0000329)1.90189412
88Agnosia (HP:0010524)1.87471504
89Lipid accumulation in hepatocytes (HP:0006561)1.85524878
90Absent epiphyses (HP:0010577)1.84812239
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84812239
92Hemivertebrae (HP:0002937)1.84799318
93Morphological abnormality of the inner ear (HP:0011390)1.84088748
94Abnormality of methionine metabolism (HP:0010901)1.82775535
95Squamous cell carcinoma (HP:0002860)1.79906312
96Acute encephalopathy (HP:0006846)1.79853682
97Neoplasm of the colon (HP:0100273)1.79555521
98Acute necrotizing encephalopathy (HP:0006965)1.78516385
99Breast aplasia (HP:0100783)1.78223090
100Holoprosencephaly (HP:0001360)1.78005311
101High anterior hairline (HP:0009890)1.77758967
102Aplasia/Hypoplasia of the breasts (HP:0010311)1.77526735
103Missing ribs (HP:0000921)1.77385364
104Abnormal trabecular bone morphology (HP:0100671)1.77073044
105Microretrognathia (HP:0000308)1.75559313
106Esophageal atresia (HP:0002032)1.73247278
107Optic nerve coloboma (HP:0000588)1.72323248
108Bifid tongue (HP:0010297)1.71546580
109Microvesicular hepatic steatosis (HP:0001414)1.71411028
110Abnormal spermatogenesis (HP:0008669)1.71242758
111Arteriovenous malformation (HP:0100026)1.70970726
112Deviation of the thumb (HP:0009603)1.70951762
113Shawl scrotum (HP:0000049)1.70211860
114Irregular epiphyses (HP:0010582)1.69320435
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68653973
116Preaxial hand polydactyly (HP:0001177)1.68246533
117Oligodactyly (hands) (HP:0001180)1.68062887
118Acute lymphatic leukemia (HP:0006721)1.67907616
119Pallor (HP:0000980)1.67347122
120Volvulus (HP:0002580)1.66994225
121Abnormal umbilical cord blood vessels (HP:0011403)1.66367573
122Single umbilical artery (HP:0001195)1.66367573
123Abnormality of the fetal cardiovascular system (HP:0010948)1.66367573
124Abnormality of the umbilical cord (HP:0010881)1.66162594
125Proximal placement of thumb (HP:0009623)1.65840382
126Glioma (HP:0009733)1.64843404
127Capillary hemangiomas (HP:0005306)1.64618394
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.64434583
129Dandy-Walker malformation (HP:0001305)1.63928777
130Abnormal mitochondria in muscle tissue (HP:0008316)1.63874956
131Small epiphyses (HP:0010585)1.63543829
132Hypoplasia of the pons (HP:0012110)1.63535742
133Abnormality of chromosome segregation (HP:0002916)1.62297490
134Oligodactyly (HP:0012165)1.61869486
135Macrocytic anemia (HP:0001972)1.61166953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.81087706
2WEE14.54175262
3CDC73.63494940
4NEK23.29022968
5PLK42.91425712
6SRPK12.86686648
7TTK2.78662191
8EIF2AK12.74843184
9VRK22.73070119
10* PLK12.54802555
11NEK12.47927339
12CCNB12.38027880
13AURKB2.21937795
14MKNK12.18790828
15* PLK31.95933650
16STK38L1.93642386
17* BRSK11.88146973
18ZAK1.84916390
19MKNK21.83573434
20VRK11.78077024
21STK41.70458635
22AURKA1.69107448
23ATR1.65617365
24TAF11.64011327
25STK101.58509583
26CDK71.53650019
27* BRSK21.53431838
28EIF2AK31.45458367
29TLK11.44645997
30ACVR1B1.43550735
31PASK1.41787588
32RPS6KA41.40266410
33* CHEK21.38876657
34PBK1.37104351
35TSSK61.33628384
36PNCK1.33343241
37MELK1.31804398
38MAP3K81.30295514
39* CHEK11.27056114
40CDK121.24074703
41TESK21.21131818
42STK161.19634789
43EIF2AK21.16866864
44TRIM281.15595622
45DYRK31.11180104
46STK31.09829845
47CDK41.06801352
48NME21.06764691
49NME11.04146546
50ATM1.02301946
51CLK10.97609102
52TNIK0.95710913
53CDK80.92404811
54RPS6KB20.92228938
55* CDK20.86609495
56* CDK10.79823360
57SMG10.78585009
58BRAF0.78121794
59WNK30.75834425
60EPHA20.75667802
61LATS20.73745964
62STK240.72430291
63PAK10.72204438
64PAK40.69032089
65TGFBR10.67618397
66PRKCI0.65733739
67PDK30.62165691
68PDK40.62165691
69SCYL20.61501920
70PIM10.61196943
71* CSNK2A10.60921970
72LATS10.59686153
73AKT30.55415732
74BMPR1B0.53628818
75CDK60.52643333
76NUAK10.51238751
77BRD40.50236720
78OBSCN0.50104750
79TESK10.48935459
80CSNK2A20.48651719
81ERBB40.48074437
82NEK60.48041177
83RPS6KA50.46584485
84ERBB30.44841891
85PDK20.44223706
86FGFR10.41607839
87CDK180.41585934
88AKT20.40850388
89CDK150.39671422
90DYRK20.39222449
91CDK11A0.39137673
92PLK20.38928461
93FLT30.36630469
94NEK90.35806067
95TAOK20.35739899
96DMPK0.34626561
97MAP3K100.32972940
98RAF10.32016576
99PRKDC0.31890079
100CDK90.31605863
101CDK140.30504922
102YES10.29070401
103CDK30.27488224
104MAPKAPK50.27387448
105BCR0.25061395
106CHUK0.24241115
107* MAPK140.23561147
108EEF2K0.23312815
109CSNK1G10.23099491
110AKT10.21471420
111ALK0.21025946
112UHMK10.20873123
113MINK10.19131069
114MET0.18969697
115TRPM70.18247737
116RPS6KA60.17551694
117RPS6KC10.16492980
118RPS6KL10.16492980
119GSK3B0.16198919
120MAPK110.15639864
121RPS6KB10.14934253
122MST40.13660563
123CSNK1E0.13344384
124MAP2K30.12983358

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59763127
2Mismatch repair_Homo sapiens_hsa034304.08586032
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.72171335
4RNA polymerase_Homo sapiens_hsa030203.52098381
5* Cell cycle_Homo sapiens_hsa041103.47337078
6Homologous recombination_Homo sapiens_hsa034403.44317060
7RNA transport_Homo sapiens_hsa030133.33541251
8Spliceosome_Homo sapiens_hsa030403.30384346
9Base excision repair_Homo sapiens_hsa034103.09941868
10Proteasome_Homo sapiens_hsa030502.98963782
11Fanconi anemia pathway_Homo sapiens_hsa034602.87718054
12Nucleotide excision repair_Homo sapiens_hsa034202.84340135
13Ribosome_Homo sapiens_hsa030102.61935725
14Pyrimidine metabolism_Homo sapiens_hsa002402.41779291
15Basal transcription factors_Homo sapiens_hsa030222.41195997
16Non-homologous end-joining_Homo sapiens_hsa034502.33842900
17One carbon pool by folate_Homo sapiens_hsa006702.22890193
18RNA degradation_Homo sapiens_hsa030182.21648227
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14348360
20p53 signaling pathway_Homo sapiens_hsa041151.99297482
21mRNA surveillance pathway_Homo sapiens_hsa030151.91839051
22Vitamin B6 metabolism_Homo sapiens_hsa007501.63256425
23* Oocyte meiosis_Homo sapiens_hsa041141.44228575
24Purine metabolism_Homo sapiens_hsa002301.40092629
25Pyruvate metabolism_Homo sapiens_hsa006201.39376751
26Steroid biosynthesis_Homo sapiens_hsa001001.35375756
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31165386
28Systemic lupus erythematosus_Homo sapiens_hsa053221.30279358
29Epstein-Barr virus infection_Homo sapiens_hsa051691.25832575
30* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25692371
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13096246
32Propanoate metabolism_Homo sapiens_hsa006401.06284398
33Fatty acid elongation_Homo sapiens_hsa000620.95819433
34Viral carcinogenesis_Homo sapiens_hsa052030.95739882
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92727836
36Herpes simplex infection_Homo sapiens_hsa051680.91896545
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91168797
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89185047
39Selenocompound metabolism_Homo sapiens_hsa004500.81024360
40HTLV-I infection_Homo sapiens_hsa051660.78456486
41Pentose phosphate pathway_Homo sapiens_hsa000300.77014612
42Antigen processing and presentation_Homo sapiens_hsa046120.75297340
43* MicroRNAs in cancer_Homo sapiens_hsa052060.75255464
44Huntingtons disease_Homo sapiens_hsa050160.71125795
45Biosynthesis of amino acids_Homo sapiens_hsa012300.68626883
46Lysine degradation_Homo sapiens_hsa003100.67947091
47Thyroid cancer_Homo sapiens_hsa052160.66276952
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66094766
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65568749
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65545865
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65023332
52Hippo signaling pathway_Homo sapiens_hsa043900.63443966
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62923079
54TGF-beta signaling pathway_Homo sapiens_hsa043500.62763071
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.61507948
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59837763
57Small cell lung cancer_Homo sapiens_hsa052220.59626402
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.56837159
59Alzheimers disease_Homo sapiens_hsa050100.53975785
60Basal cell carcinoma_Homo sapiens_hsa052170.51086018
61Protein export_Homo sapiens_hsa030600.47762039
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47412520
63Glutathione metabolism_Homo sapiens_hsa004800.47340074
64Fatty acid metabolism_Homo sapiens_hsa012120.46165112
65Alcoholism_Homo sapiens_hsa050340.45557056
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44919538
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43624459
68Carbon metabolism_Homo sapiens_hsa012000.41343253
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40942067
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40376044
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40017894
72Legionellosis_Homo sapiens_hsa051340.39950134
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39282671
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38568237
75Arginine and proline metabolism_Homo sapiens_hsa003300.37300897
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.36008794
77Parkinsons disease_Homo sapiens_hsa050120.34818526
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33049131
79Folate biosynthesis_Homo sapiens_hsa007900.31429192
80Colorectal cancer_Homo sapiens_hsa052100.31193736
81Apoptosis_Homo sapiens_hsa042100.30345095
82Arachidonic acid metabolism_Homo sapiens_hsa005900.30066158
83Notch signaling pathway_Homo sapiens_hsa043300.29671393
84Hepatitis B_Homo sapiens_hsa051610.29270327
85Adherens junction_Homo sapiens_hsa045200.27358180
86Galactose metabolism_Homo sapiens_hsa000520.27191669
87FoxO signaling pathway_Homo sapiens_hsa040680.26697423
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25903258
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25595384
90Hedgehog signaling pathway_Homo sapiens_hsa043400.24915037
91Butanoate metabolism_Homo sapiens_hsa006500.24689601
92HIF-1 signaling pathway_Homo sapiens_hsa040660.24087225
93Bladder cancer_Homo sapiens_hsa052190.23096731
94Pathways in cancer_Homo sapiens_hsa052000.23022658
95Influenza A_Homo sapiens_hsa051640.22896584
96Primary immunodeficiency_Homo sapiens_hsa053400.20376903
97Fructose and mannose metabolism_Homo sapiens_hsa000510.19828196
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18897807
99Metabolic pathways_Homo sapiens_hsa011000.18789002
100Measles_Homo sapiens_hsa051620.18513010
101N-Glycan biosynthesis_Homo sapiens_hsa005100.17997119
102Vitamin digestion and absorption_Homo sapiens_hsa049770.17819140
103Prostate cancer_Homo sapiens_hsa052150.16972965
104Fatty acid degradation_Homo sapiens_hsa000710.16924098
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14244674
106Wnt signaling pathway_Homo sapiens_hsa043100.14011064
107Chronic myeloid leukemia_Homo sapiens_hsa052200.12779718
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12262543
109Tight junction_Homo sapiens_hsa045300.12066060
110Shigellosis_Homo sapiens_hsa051310.11838453
111Arginine biosynthesis_Homo sapiens_hsa002200.11483932
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.11107359
113Melanoma_Homo sapiens_hsa052180.10924776
114Sulfur relay system_Homo sapiens_hsa041220.09472945
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09259706
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07863203
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.07690324
118Non-small cell lung cancer_Homo sapiens_hsa052230.07472904
119Hematopoietic cell lineage_Homo sapiens_hsa046400.07327046
120Fat digestion and absorption_Homo sapiens_hsa049750.06763476
121Cardiac muscle contraction_Homo sapiens_hsa042600.05258750
122Oxidative phosphorylation_Homo sapiens_hsa001900.04726694
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.04257785

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