CDC26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.19604632
2maturation of SSU-rRNA (GO:0030490)6.17484702
3chaperone-mediated protein transport (GO:0072321)6.15606201
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.01096796
5ribosomal small subunit biogenesis (GO:0042274)5.90500889
6viral transcription (GO:0019083)5.81500247
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.68780213
8translational termination (GO:0006415)5.59585335
9respiratory electron transport chain (GO:0022904)5.26349130
10electron transport chain (GO:0022900)5.15891772
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08046695
12cotranslational protein targeting to membrane (GO:0006613)5.03055451
13protein targeting to ER (GO:0045047)4.97015049
14ribosomal large subunit biogenesis (GO:0042273)4.79870631
15mitochondrial respiratory chain complex assembly (GO:0033108)4.77506587
16translational elongation (GO:0006414)4.77065707
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.71331163
18protein localization to endoplasmic reticulum (GO:0070972)4.68049455
19proteasome assembly (GO:0043248)4.59501210
20polyketide metabolic process (GO:0030638)4.54755116
21doxorubicin metabolic process (GO:0044598)4.54755116
22daunorubicin metabolic process (GO:0044597)4.54755116
23NADH dehydrogenase complex assembly (GO:0010257)4.42996568
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42996568
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.42996568
26viral life cycle (GO:0019058)4.39300477
27transcription elongation from RNA polymerase III promoter (GO:0006385)4.38709525
28termination of RNA polymerase III transcription (GO:0006386)4.38709525
29cellular protein complex disassembly (GO:0043624)4.32503265
30translational initiation (GO:0006413)4.29113158
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28927086
32DNA deamination (GO:0045006)4.10095035
33respiratory chain complex IV assembly (GO:0008535)4.00917958
34regulation of cellular amino acid metabolic process (GO:0006521)3.99819944
35establishment of integrated proviral latency (GO:0075713)3.98841377
36telomere maintenance via semi-conservative replication (GO:0032201)3.92455626
37cytochrome complex assembly (GO:0017004)3.92208840
38translation (GO:0006412)3.86826477
39ribonucleoprotein complex biogenesis (GO:0022613)3.83619145
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74239200
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74239200
42protein complex disassembly (GO:0043241)3.72301499
43protein targeting to mitochondrion (GO:0006626)3.65439574
44rRNA modification (GO:0000154)3.64228249
45CENP-A containing nucleosome assembly (GO:0034080)3.63437394
46DNA strand elongation involved in DNA replication (GO:0006271)3.62285864
47chromatin remodeling at centromere (GO:0031055)3.59897647
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59351426
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.59351426
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.58581382
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.56441602
52macromolecular complex disassembly (GO:0032984)3.54778300
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50635736
54rRNA processing (GO:0006364)3.50179512
55* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.49823160
56water-soluble vitamin biosynthetic process (GO:0042364)3.48017143
57inner mitochondrial membrane organization (GO:0007007)3.47632179
58transcription-coupled nucleotide-excision repair (GO:0006283)3.47257736
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47030075
60DNA strand elongation (GO:0022616)3.46017526
61establishment of protein localization to mitochondrion (GO:0072655)3.44846500
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44270808
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44270808
64protein localization to mitochondrion (GO:0070585)3.44214373
65telomere maintenance via recombination (GO:0000722)3.43338617
66ATP biosynthetic process (GO:0006754)3.42848360
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.39248184
68cullin deneddylation (GO:0010388)3.38633310
69telomere maintenance via telomere lengthening (GO:0010833)3.37053037
70rRNA metabolic process (GO:0016072)3.36788153
71DNA double-strand break processing (GO:0000729)3.36654320
72* positive regulation of ligase activity (GO:0051351)3.34716560
73DNA damage response, detection of DNA damage (GO:0042769)3.34537309
74hydrogen ion transmembrane transport (GO:1902600)3.32188150
75spliceosomal snRNP assembly (GO:0000387)3.28272944
767-methylguanosine mRNA capping (GO:0006370)3.28191001
777-methylguanosine RNA capping (GO:0009452)3.27380377
78RNA capping (GO:0036260)3.27380377
79purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26825933
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.26578717
81protein deneddylation (GO:0000338)3.26313001
82cellular component biogenesis (GO:0044085)3.26085819
83regulation of mitochondrial translation (GO:0070129)3.24158394
84transcription elongation from RNA polymerase I promoter (GO:0006362)3.24132216
85regulation of mitotic spindle checkpoint (GO:1903504)3.23306517
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23306517
87mRNA catabolic process (GO:0006402)3.22982403
88intracellular protein transmembrane import (GO:0044743)3.21552768
89histone exchange (GO:0043486)3.21031309
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.20788925
91kinetochore assembly (GO:0051382)3.18544249
92termination of RNA polymerase I transcription (GO:0006363)3.18261343
93histone mRNA metabolic process (GO:0008334)3.18090601
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17577927
95establishment of viral latency (GO:0019043)3.16079265
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14815021
97* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13907513
98mitotic recombination (GO:0006312)3.13765615
99kinetochore organization (GO:0051383)3.12657751
100DNA replication-independent nucleosome organization (GO:0034724)3.12633601
101DNA replication-independent nucleosome assembly (GO:0006336)3.12633601
102* regulation of ubiquitin-protein transferase activity (GO:0051438)3.10334812
103DNA replication initiation (GO:0006270)3.07631653
104rRNA methylation (GO:0031167)3.06199359
105spliceosomal complex assembly (GO:0000245)3.05651117
106DNA ligation (GO:0006266)3.05338234
107transcription from RNA polymerase I promoter (GO:0006360)3.05037435
108pseudouridine synthesis (GO:0001522)3.04266537
109platelet dense granule organization (GO:0060155)3.04148236
110oxidative phosphorylation (GO:0006119)3.04009150
111mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.03110888
112viral mRNA export from host cell nucleus (GO:0046784)3.03098426
113RNA catabolic process (GO:0006401)3.02125303
114protein targeting to membrane (GO:0006612)3.01492229
115proton transport (GO:0015992)3.00637456
116* regulation of ligase activity (GO:0051340)2.99371112
117protein neddylation (GO:0045116)2.98880903
118mitochondrial transport (GO:0006839)2.97515993
119DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95684090
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.94802906
121deoxyribonucleotide biosynthetic process (GO:0009263)2.92259074
122* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91026813
123DNA catabolic process, exonucleolytic (GO:0000738)2.90021541
124* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89847758
125antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89632190
126GTP biosynthetic process (GO:0006183)2.89307097
127DNA-templated transcription, termination (GO:0006353)2.87924495
128DNA replication checkpoint (GO:0000076)2.87814213
129regulation of DNA methylation (GO:0044030)2.87785461
130* negative regulation of ligase activity (GO:0051352)2.86280698
131* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86280698
132ATP synthesis coupled proton transport (GO:0015986)2.85794763
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85794763
134formation of translation preinitiation complex (GO:0001731)2.85729108
135protein complex biogenesis (GO:0070271)2.81777779
136* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81676413
137ncRNA processing (GO:0034470)2.81459590
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78962516
139preassembly of GPI anchor in ER membrane (GO:0016254)2.78852131
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78583663
141signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78583663
142signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78583663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.29801126
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62300105
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31253923
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.19157638
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.91114962
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.83549309
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41785646
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34518690
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32882691
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.24624360
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05505051
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91613018
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85196832
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84885482
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81082777
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79734713
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77326643
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68626840
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61093916
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59095107
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.41906852
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41850404
23VDR_23849224_ChIP-Seq_CD4+_Human2.41472837
24ELK1_19687146_ChIP-ChIP_HELA_Human2.38769364
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34673987
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27544098
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24387445
28XRN2_22483619_ChIP-Seq_HELA_Human2.17242388
29IRF1_19129219_ChIP-ChIP_H3396_Human2.15739004
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14615693
31FOXP3_21729870_ChIP-Seq_TREG_Human2.12726492
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.10605532
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09249239
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09249239
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09249239
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08578334
37* TTF2_22483619_ChIP-Seq_HELA_Human2.07273701
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01970680
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95991865
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94669603
41* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87692412
42DCP1A_22483619_ChIP-Seq_HELA_Human1.83237148
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81098385
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80993051
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80202582
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.77457408
47GABP_19822575_ChIP-Seq_HepG2_Human1.61190046
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59523621
49* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59489149
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.55090598
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54718129
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.53844625
53MYC_18940864_ChIP-ChIP_HL60_Human1.53777412
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53070311
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52086212
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49539612
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44623839
58ZNF274_21170338_ChIP-Seq_K562_Hela1.43227829
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43095882
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39643240
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37791370
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37610124
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.31826874
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31606638
65FUS_26573619_Chip-Seq_HEK293_Human1.31114689
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29053215
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27996481
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27369909
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25498403
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24000619
71CIITA_25753668_ChIP-Seq_RAJI_Human1.22890548
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.19283429
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18386210
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.18254754
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15148115
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13531395
77EWS_26573619_Chip-Seq_HEK293_Human1.13315532
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12252002
79* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10874787
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09002707
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08887780
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08258534
83VDR_22108803_ChIP-Seq_LS180_Human1.07466208
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.06573129
85TP53_22573176_ChIP-Seq_HFKS_Human1.06339251
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05141697
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02238814
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01552931
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00303764
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99185526
91IGF1R_20145208_ChIP-Seq_DFB_Human0.97835776
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97707864
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.97384318
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94468340
95P300_19829295_ChIP-Seq_ESCs_Human0.93503191
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92848840
97HTT_18923047_ChIP-ChIP_STHdh_Human0.92770008
98SPI1_23547873_ChIP-Seq_NB4_Human0.90190791
99SOX2_19829295_ChIP-Seq_ESCs_Human0.89266178
100NANOG_19829295_ChIP-Seq_ESCs_Human0.89266178
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.88960106
102AR_20517297_ChIP-Seq_VCAP_Human0.85311541
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85004375
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84430945
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.84430945
106* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83978592
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83939275
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83876248
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83505263
110* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82351615
111AR_21909140_ChIP-Seq_LNCAP_Human0.82191283
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81889968
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81114298
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.79836768
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78556068
116RBPJ_21746931_ChIP-Seq_IB4_Human0.76409684
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75185218
118TAF15_26573619_Chip-Seq_HEK293_Human0.74570909
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74031966
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.73682733
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.73442085
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.70142346
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69340042
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68568493
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68065654
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67945926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.37519891
2MP0008877_abnormal_DNA_methylation4.22588658
3MP0006292_abnormal_olfactory_placode3.53577852
4MP0003111_abnormal_nucleus_morphology3.21417510
5MP0003693_abnormal_embryo_hatching3.20245175
6MP0008058_abnormal_DNA_repair2.88804589
7MP0010094_abnormal_chromosome_stability2.82414414
8MP0005409_darkened_coat_color2.54909832
9MP0001188_hyperpigmentation2.49831771
10MP0000516_abnormal_urinary_system2.47143757
11MP0005367_renal/urinary_system_phenotyp2.47143757
12MP0008007_abnormal_cellular_replicative2.41351354
13MP0000566_synostosis2.30254611
14MP0008057_abnormal_DNA_replication2.28053501
15MP0006036_abnormal_mitochondrial_physio2.23015694
16MP0005670_abnormal_white_adipose2.21821170
17MP0002132_abnormal_respiratory_system2.21585533
18MP0003077_abnormal_cell_cycle2.21454294
19MP0004957_abnormal_blastocyst_morpholog2.15869325
20MP0008932_abnormal_embryonic_tissue2.11666477
21MP0002938_white_spotting1.98762976
22MP0002638_abnormal_pupillary_reflex1.96999516
23MP0005084_abnormal_gallbladder_morpholo1.96046234
24MP0004381_abnormal_hair_follicle1.94952516
25MP0002102_abnormal_ear_morphology1.91881791
26MP0005671_abnormal_response_to1.91770422
27MP0003195_calcinosis1.88233645
28MP0003136_yellow_coat_color1.82369455
29MP0005174_abnormal_tail_pigmentation1.77473936
30MP0008789_abnormal_olfactory_epithelium1.67767812
31MP0005075_abnormal_melanosome_morpholog1.67131149
32MP0002277_abnormal_respiratory_mucosa1.63547577
33MP0003123_paternal_imprinting1.55747283
34MP0002837_dystrophic_cardiac_calcinosis1.55616812
35MP0002736_abnormal_nociception_after1.53159200
36MP0004133_heterotaxia1.48819118
37MP0000049_abnormal_middle_ear1.45336658
38MP0004147_increased_porphyrin_level1.39524172
39MP0010030_abnormal_orbit_morphology1.37510876
40MP0003315_abnormal_perineum_morphology1.37171189
41MP0003786_premature_aging1.36000277
42MP0002396_abnormal_hematopoietic_system1.35280419
43MP0000015_abnormal_ear_pigmentation1.34258772
44MP0003567_abnormal_fetal_cardiomyocyte1.34118206
45MP0002095_abnormal_skin_pigmentation1.34081915
46MP0001835_abnormal_antigen_presentation1.31306668
47MP0003718_maternal_effect1.30675367
48MP0005171_absent_coat_pigmentation1.30391798
49MP0002148_abnormal_hypersensitivity_rea1.28217711
50MP0009785_altered_susceptibility_to1.28010456
51MP0002751_abnormal_autonomic_nervous1.26081024
52MP0005408_hypopigmentation1.23024685
53MP0001986_abnormal_taste_sensitivity1.22467090
54MP0002234_abnormal_pharynx_morphology1.21903939
55MP0001764_abnormal_homeostasis1.21700299
56MP0003878_abnormal_ear_physiology1.19289745
57MP0005377_hearing/vestibular/ear_phenot1.19289745
58MP0008875_abnormal_xenobiotic_pharmacok1.16864042
59MP0002735_abnormal_chemical_nociception1.14490790
60MP0001286_abnormal_eye_development1.14099897
61MP0003938_abnormal_ear_development1.13324988
62MP0001905_abnormal_dopamine_level1.11897249
63MP0003941_abnormal_skin_development1.10942511
64MP0001485_abnormal_pinna_reflex1.10847844
65MP0005394_taste/olfaction_phenotype1.08603965
66MP0005499_abnormal_olfactory_system1.08603965
67MP0008872_abnormal_physiological_respon1.08206195
68MP0000490_abnormal_crypts_of1.06510937
69MP0003724_increased_susceptibility_to1.06446122
70MP0003890_abnormal_embryonic-extraembry1.06425291
71MP0001293_anophthalmia1.04926521
72MP0000372_irregular_coat_pigmentation1.00962645
73MP0005551_abnormal_eye_electrophysiolog1.00509558
74MP0003937_abnormal_limbs/digits/tail_de0.99884339
75MP0006072_abnormal_retinal_apoptosis0.97977397
76MP0005410_abnormal_fertilization0.97877154
77MP0004808_abnormal_hematopoietic_stem0.97698038
78MP0003186_abnormal_redox_activity0.93123956
79MP0002233_abnormal_nose_morphology0.93121627
80MP0009250_abnormal_appendicular_skeleto0.92313271
81MP0006054_spinal_hemorrhage0.91778627
82MP0009697_abnormal_copulation0.90452751
83MP0001186_pigmentation_phenotype0.87986332
84MP0000762_abnormal_tongue_morphology0.87791594
85MP0002177_abnormal_outer_ear0.86316028
86MP0001919_abnormal_reproductive_system0.85170579
87MP0005645_abnormal_hypothalamus_physiol0.84972777
88MP0000613_abnormal_salivary_gland0.84774535
89MP0001929_abnormal_gametogenesis0.82502931
90MP0003763_abnormal_thymus_physiology0.82275193
91MP0009765_abnormal_xenobiotic_induced0.81986985
92MP0005646_abnormal_pituitary_gland0.81851282
93MP0006035_abnormal_mitochondrial_morpho0.81695089
94MP0005389_reproductive_system_phenotype0.80057855
95MP0003011_delayed_dark_adaptation0.79053434
96MP0003806_abnormal_nucleotide_metabolis0.78728468
97MP0002090_abnormal_vision0.78395344
98MP0001529_abnormal_vocalization0.78388286
99MP0005636_abnormal_mineral_homeostasis0.77643832
100MP0001853_heart_inflammation0.76988650
101MP0005395_other_phenotype0.76684338
102MP0000653_abnormal_sex_gland0.76645832
103MP0009333_abnormal_splenocyte_physiolog0.76568408
104MP0000313_abnormal_cell_death0.76192478
105MP0002254_reproductive_system_inflammat0.76101964
106MP0003787_abnormal_imprinting0.75853491
107MP0003121_genomic_imprinting0.74446479
108MP0005332_abnormal_amino_acid0.73913659
109MP0004215_abnormal_myocardial_fiber0.73716782
110MP0000350_abnormal_cell_proliferation0.73096490
111MP0000703_abnormal_thymus_morphology0.72547349
112MP0004142_abnormal_muscle_tone0.72255159
113MP0003137_abnormal_impulse_conducting0.71787334
114MP0002282_abnormal_trachea_morphology0.71232434
115MP0005391_vision/eye_phenotype0.71177786
116MP0000358_abnormal_cell_content/0.70523501
117MP0002210_abnormal_sex_determination0.70390301
118MP0000647_abnormal_sebaceous_gland0.69768650
119MP0006082_CNS_inflammation0.68587920
120MP0008873_increased_physiological_sensi0.67357704
121MP0002098_abnormal_vibrissa_morphology0.66880818
122MP0002160_abnormal_reproductive_system0.66683679
123MP0005253_abnormal_eye_physiology0.66576103
124MP0001145_abnormal_male_reproductive0.66417925
125MP0002697_abnormal_eye_size0.64550904
126MP0005379_endocrine/exocrine_gland_phen0.64228027
127MP0001873_stomach_inflammation0.64066895
128MP0000026_abnormal_inner_ear0.62477031
129MP0000569_abnormal_digit_pigmentation0.62158311
130MP0002163_abnormal_gland_morphology0.62051268
131MP0008995_early_reproductive_senescence0.61581204
132MP0004134_abnormal_chest_morphology0.61164381
133MP0002111_abnormal_tail_morphology0.60569862
134MP0002116_abnormal_craniofacial_bone0.59790942
135MP0002075_abnormal_coat/hair_pigmentati0.59604937
136MP0001346_abnormal_lacrimal_gland0.59392645
137MP0003385_abnormal_body_wall0.58615690
138MP0000631_abnormal_neuroendocrine_gland0.58513131
139MP0001119_abnormal_female_reproductive0.58222111
140MP0001984_abnormal_olfaction0.57632334

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.87277747
2Abnormality of cells of the erythroid lineage (HP:0012130)4.81931355
3Abnormal number of erythroid precursors (HP:0012131)4.60920348
4Cerebral edema (HP:0002181)4.08052897
5Macrocytic anemia (HP:0001972)3.82776677
6Increased intramyocellular lipid droplets (HP:0012240)3.49813153
7Cerebellar dysplasia (HP:0007033)3.41816872
8Pallor (HP:0000980)3.30930325
9Poor head control (HP:0002421)3.10506819
10Methylmalonic acidemia (HP:0002912)3.09686766
11Birth length less than 3rd percentile (HP:0003561)3.07753446
123-Methylglutaconic aciduria (HP:0003535)3.02818503
13Abnormality of the pons (HP:0007361)3.01985848
14Increased hepatocellular lipid droplets (HP:0006565)3.01600113
15Aplastic anemia (HP:0001915)3.00928044
16Lactic acidosis (HP:0003128)2.99181962
17Type I transferrin isoform profile (HP:0003642)2.98535090
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96121819
19Respiratory failure (HP:0002878)2.93314338
20Breast hypoplasia (HP:0003187)2.92808292
21Hypoplasia of the pons (HP:0012110)2.89462541
22Meckel diverticulum (HP:0002245)2.88196894
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87934408
24Renal Fanconi syndrome (HP:0001994)2.86161103
25Increased muscle lipid content (HP:0009058)2.83220442
26Microvesicular hepatic steatosis (HP:0001414)2.83017552
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82633923
28Mitochondrial inheritance (HP:0001427)2.79152796
29Optic disc pallor (HP:0000543)2.77530188
30Severe visual impairment (HP:0001141)2.74566565
31Acute necrotizing encephalopathy (HP:0006965)2.74117571
32Leukodystrophy (HP:0002415)2.73732042
33Abnormality of the preputium (HP:0100587)2.73552510
34Abnormality of the ileum (HP:0001549)2.73093067
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68919082
36Chromsome breakage (HP:0040012)2.67241638
37Methylmalonic aciduria (HP:0012120)2.66797190
38Triphalangeal thumb (HP:0001199)2.63524778
39Abnormality of renal resorption (HP:0011038)2.63301274
40Intestinal atresia (HP:0011100)2.62768991
41Respiratory difficulties (HP:0002880)2.57056925
42Lethargy (HP:0001254)2.55808702
43Type II lissencephaly (HP:0007260)2.54460732
44Lipid accumulation in hepatocytes (HP:0006561)2.50209657
45Hepatocellular necrosis (HP:0001404)2.48213142
4611 pairs of ribs (HP:0000878)2.42784796
47Abnormality of midbrain morphology (HP:0002418)2.38782445
48Molar tooth sign on MRI (HP:0002419)2.38782445
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.37948720
50Pancreatic fibrosis (HP:0100732)2.34894303
51Abnormal mitochondria in muscle tissue (HP:0008316)2.33152219
52Abnormality of methionine metabolism (HP:0010901)2.32886456
53Abnormality of secondary sexual hair (HP:0009888)2.32105407
54Abnormality of the axillary hair (HP:0100134)2.32105407
55Duplicated collecting system (HP:0000081)2.31768032
56Septo-optic dysplasia (HP:0100842)2.30705971
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29691180
58True hermaphroditism (HP:0010459)2.27865455
59Abnormality of chromosome stability (HP:0003220)2.26759768
60Abnormal lung lobation (HP:0002101)2.25713937
61Increased CSF lactate (HP:0002490)2.25580999
62Exertional dyspnea (HP:0002875)2.24504679
63Abnormality of urine glucose concentration (HP:0011016)2.20734402
64Glycosuria (HP:0003076)2.20734402
65Reduced antithrombin III activity (HP:0001976)2.20269913
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19934878
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19934878
68Calf muscle hypertrophy (HP:0008981)2.19803752
69Abnormality of the renal collecting system (HP:0004742)2.18653835
70Cerebral hypomyelination (HP:0006808)2.16546855
71Congenital, generalized hypertrichosis (HP:0004540)2.11442489
72Bone marrow hypocellularity (HP:0005528)2.09245086
73Hepatic necrosis (HP:0002605)2.09235418
74Progressive macrocephaly (HP:0004481)2.06785539
75Oral leukoplakia (HP:0002745)2.05503777
76Generalized aminoaciduria (HP:0002909)2.05498144
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01415724
78Medial flaring of the eyebrow (HP:0010747)2.01258576
79Absent radius (HP:0003974)2.00722928
80Absent thumb (HP:0009777)2.00048171
81CNS demyelination (HP:0007305)1.99869043
82Duodenal stenosis (HP:0100867)1.99275648
83Small intestinal stenosis (HP:0012848)1.99275648
84Cleft eyelid (HP:0000625)1.98463980
85Nonprogressive disorder (HP:0003680)1.98221199
86Increased serum lactate (HP:0002151)1.97825936
87Stenosis of the external auditory canal (HP:0000402)1.97232450
88Aplasia/hypoplasia of the uterus (HP:0008684)1.96712155
89Muscle hypertrophy of the lower extremities (HP:0008968)1.96630117
90Abnormality of the duodenum (HP:0002246)1.96038253
91IgG deficiency (HP:0004315)1.96029255
92Hyperphosphaturia (HP:0003109)1.95208461
93Abnormal protein glycosylation (HP:0012346)1.94731131
94Abnormal glycosylation (HP:0012345)1.94731131
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94731131
96Abnormal protein N-linked glycosylation (HP:0012347)1.94731131
97Rough bone trabeculation (HP:0100670)1.94128076
98Acute encephalopathy (HP:0006846)1.93713875
99X-linked dominant inheritance (HP:0001423)1.93330742
100Supernumerary spleens (HP:0009799)1.90979911
101Absent forearm bone (HP:0003953)1.90899524
102Aplasia involving forearm bones (HP:0009822)1.90899524
103Myelodysplasia (HP:0002863)1.90483061
104Abnormality of vitamin B metabolism (HP:0004340)1.89646071
105Pendular nystagmus (HP:0012043)1.88476862
106Abnormality of placental membranes (HP:0011409)1.87995549
107Amniotic constriction ring (HP:0009775)1.87995549
108Nephronophthisis (HP:0000090)1.87729522
109Abnormality of the vitamin B12 metabolism (HP:0004341)1.87202147
110Abnormality of the labia minora (HP:0012880)1.85672826
111Sparse eyelashes (HP:0000653)1.85505996
112Exercise intolerance (HP:0003546)1.84772668
113Medulloblastoma (HP:0002885)1.84705893
114Colon cancer (HP:0003003)1.84624931
115Hypoplasia of the radius (HP:0002984)1.84539169
116Premature graying of hair (HP:0002216)1.83296855
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.82954706
118Abnormality of serum amino acid levels (HP:0003112)1.82575431
119Megaloblastic anemia (HP:0001889)1.81340519
120Pancytopenia (HP:0001876)1.81335525
121Patellar aplasia (HP:0006443)1.80652332
122Shoulder girdle muscle weakness (HP:0003547)1.80268979
123Severe combined immunodeficiency (HP:0004430)1.79410334
124Hyperglycinemia (HP:0002154)1.76744495
125Absent septum pellucidum (HP:0001331)1.76432995
126Abnormal number of incisors (HP:0011064)1.76149946
127Renal hypoplasia (HP:0000089)1.76033518
128Nephroblastoma (Wilms tumor) (HP:0002667)1.75096708
129Progressive external ophthalmoplegia (HP:0000590)1.74765459
130Abnormality of eosinophils (HP:0001879)1.74523459
131Abnormal sex determination (HP:0012244)1.74115675
132Sex reversal (HP:0012245)1.74115675
133Cellular immunodeficiency (HP:0005374)1.73343321
134Horseshoe kidney (HP:0000085)1.73187506
135Aplasia/Hypoplasia of the patella (HP:0006498)1.73147849
136Dicarboxylic aciduria (HP:0003215)1.72807709
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72807709
138Type 2 muscle fiber atrophy (HP:0003554)1.72495558
139Asplenia (HP:0001746)1.72415629
140Pancreatic cysts (HP:0001737)1.72188105
141Clubbing of toes (HP:0100760)1.72014414
142Parakeratosis (HP:0001036)1.70380393
143Sclerocornea (HP:0000647)1.68820501
144Blindness (HP:0000618)1.67772587
145Optic nerve hypoplasia (HP:0000609)1.66756980
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65128802
147Congenital stationary night blindness (HP:0007642)1.65002510
148Abnormality of the fovea (HP:0000493)1.63588969
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.62645827
150Hypoplasia of the fovea (HP:0007750)1.62645827
151IgM deficiency (HP:0002850)1.61305595
152Increased serum pyruvate (HP:0003542)1.59335380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.69908480
2VRK24.66557656
3BUB13.24591075
4SRPK12.96821407
5TLK12.77378558
6VRK12.73369533
7IRAK32.64971546
8BCKDK2.53806055
9PLK42.53120676
10MKNK12.30728200
11MKNK22.26687321
12NME22.25599706
13IRAK42.16013233
14CDK192.15129996
15EIF2AK12.06997964
16WNK31.97402360
17PBK1.91156774
18IRAK11.89103111
19ZAK1.87973948
20WEE11.87721093
21MAP4K21.77134817
22MAP3K121.68255776
23IRAK21.66127756
24CDC71.63892251
25EIF2AK31.55793713
26NEK11.45917403
27TRIM281.45049410
28TNIK1.42122761
29YES11.36640480
30DYRK31.35212174
31ACVR1B1.35039617
32BMPR1B1.33736810
33INSRR1.33489599
34KDR1.31251800
35NME11.25914567
36MST41.22641685
37RPS6KA41.22055602
38TAF11.19938076
39PASK1.16346982
40CDK71.09864524
41EIF2AK21.08511428
42TESK21.08245818
43RPS6KB21.06355985
44DYRK21.05435714
45PLK11.03800008
46TXK1.02633276
47AURKB1.01102969
48PLK30.99786972
49CLK10.96585807
50TAOK30.95267389
51TEC0.92398465
52TIE10.92386642
53PIM20.91396930
54TGFBR10.89595225
55TTK0.88682935
56TSSK60.86922836
57ATR0.86375190
58EPHA20.85600836
59CASK0.82620973
60MUSK0.81434810
61FRK0.81260939
62RPS6KA50.79508612
63PIK3CG0.79276309
64NLK0.78862224
65CDK80.78031612
66STK40.71447756
67BRD40.71354450
68LYN0.70977399
69PDK20.67947232
70GRK10.67395395
71CSNK2A10.66234437
72BTK0.65449685
73CHEK20.64657148
74AURKA0.64209708
75MYLK0.59406905
76BCR0.59312680
77CSNK1G20.59136475
78NUAK10.58683202
79CDK30.58333030
80CSNK2A20.57692157
81STK38L0.54834714
82PRKCI0.54555846
83MAP2K70.53457702
84ERBB30.53024813
85DAPK10.52693359
86CHEK10.51645681
87CSNK1G30.50595909
88PNCK0.50097683
89FLT30.50010917
90ABL20.48702492
91BRSK10.47345060
92OXSR10.47065768
93IKBKB0.47013232
94ILK0.46712587
95MATK0.45686186
96BRSK20.45451206
97ATM0.45035528
98KIT0.43078281
99PRKCG0.42184844
100MAPK130.41119047
101PRKCE0.40441619
102CSNK1G10.40352033
103MAP3K40.40317372
104MARK10.39979880
105ABL10.39787416
106NEK60.39756129
107GRK70.39596478
108BLK0.37124670
109PIM10.35458539
110EPHB20.34869723
111GRK50.34781258
112PAK40.33837275
113CDK20.33643960
114CDK10.32923576
115PRKCQ0.32423966
116CSNK1A1L0.32384392
117STK100.32062361
118CCNB10.31803848
119STK30.31800700
120MAP2K60.30793398
121CSNK1A10.30448049
122ADRBK10.30403860
123ADRBK20.29947217
124STK390.29300252
125FGFR10.27934907
126PLK20.27455149
127BMPR20.27329672
128CDK90.26999497
129TRPM70.26894265
130MAPK150.26364109
131LCK0.25729424
132OBSCN0.25312173
133MAP4K10.23723553
134AKT30.23677576

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.37081221
2RNA polymerase_Homo sapiens_hsa030203.97037894
3Protein export_Homo sapiens_hsa030603.93044252
4DNA replication_Homo sapiens_hsa030303.61787176
5Homologous recombination_Homo sapiens_hsa034403.45099462
6Proteasome_Homo sapiens_hsa030503.43169318
7Mismatch repair_Homo sapiens_hsa034303.20170555
8Spliceosome_Homo sapiens_hsa030402.93022171
9Pyrimidine metabolism_Homo sapiens_hsa002402.65306136
10Nucleotide excision repair_Homo sapiens_hsa034202.44217696
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40171578
12Fanconi anemia pathway_Homo sapiens_hsa034602.36859949
13Base excision repair_Homo sapiens_hsa034102.13762557
14Oxidative phosphorylation_Homo sapiens_hsa001902.12188037
15Non-homologous end-joining_Homo sapiens_hsa034502.05117653
16Basal transcription factors_Homo sapiens_hsa030222.03998231
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91868575
18RNA transport_Homo sapiens_hsa030131.90001986
19Parkinsons disease_Homo sapiens_hsa050121.81211598
20RNA degradation_Homo sapiens_hsa030181.74103322
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69413731
22Huntingtons disease_Homo sapiens_hsa050161.58850173
23Purine metabolism_Homo sapiens_hsa002301.53793637
24One carbon pool by folate_Homo sapiens_hsa006701.51271808
25* Cell cycle_Homo sapiens_hsa041101.41746133
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38983750
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36397453
28Propanoate metabolism_Homo sapiens_hsa006401.22962732
29Alzheimers disease_Homo sapiens_hsa050101.12330483
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04011670
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97314413
32Systemic lupus erythematosus_Homo sapiens_hsa053220.96685671
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94374400
34p53 signaling pathway_Homo sapiens_hsa041150.93266501
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92587496
36Fatty acid elongation_Homo sapiens_hsa000620.87052613
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86161801
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81383925
39mRNA surveillance pathway_Homo sapiens_hsa030150.81074248
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.80377020
41Pyruvate metabolism_Homo sapiens_hsa006200.79786201
42Arachidonic acid metabolism_Homo sapiens_hsa005900.79627224
43Sulfur metabolism_Homo sapiens_hsa009200.78434435
44Epstein-Barr virus infection_Homo sapiens_hsa051690.77649094
45Peroxisome_Homo sapiens_hsa041460.77466086
46Glutathione metabolism_Homo sapiens_hsa004800.77272150
47Sphingolipid metabolism_Homo sapiens_hsa006000.76620647
48Type I diabetes mellitus_Homo sapiens_hsa049400.75622824
49Rheumatoid arthritis_Homo sapiens_hsa053230.69618559
50Chemical carcinogenesis_Homo sapiens_hsa052040.68274940
51Primary immunodeficiency_Homo sapiens_hsa053400.67948136
52Folate biosynthesis_Homo sapiens_hsa007900.67430142
53Ether lipid metabolism_Homo sapiens_hsa005650.66847437
54Butanoate metabolism_Homo sapiens_hsa006500.66382989
55Collecting duct acid secretion_Homo sapiens_hsa049660.65979859
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64606647
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62544038
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61179577
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60922061
60Selenocompound metabolism_Homo sapiens_hsa004500.58411265
61Metabolic pathways_Homo sapiens_hsa011000.56431822
62Nitrogen metabolism_Homo sapiens_hsa009100.55405989
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.54918042
64Vibrio cholerae infection_Homo sapiens_hsa051100.54917884
65Hematopoietic cell lineage_Homo sapiens_hsa046400.52444130
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.50828539
67Herpes simplex infection_Homo sapiens_hsa051680.49368988
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49305856
69Linoleic acid metabolism_Homo sapiens_hsa005910.48942701
70Autoimmune thyroid disease_Homo sapiens_hsa053200.48124648
71Sulfur relay system_Homo sapiens_hsa041220.46856539
72Asthma_Homo sapiens_hsa053100.46212791
73Caffeine metabolism_Homo sapiens_hsa002320.44264091
74Allograft rejection_Homo sapiens_hsa053300.44163055
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.43921063
76Tryptophan metabolism_Homo sapiens_hsa003800.43880726
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43220333
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.41022397
79Phototransduction_Homo sapiens_hsa047440.40028284
80Regulation of autophagy_Homo sapiens_hsa041400.39299852
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37537137
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37379561
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36850568
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36748471
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.35938124
86Steroid biosynthesis_Homo sapiens_hsa001000.35296525
87Mineral absorption_Homo sapiens_hsa049780.34704231
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33771910
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33433148
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32031983
91* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31807005
92Graft-versus-host disease_Homo sapiens_hsa053320.31699509
93Arginine and proline metabolism_Homo sapiens_hsa003300.30855428
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30820492
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.30274006
96Other glycan degradation_Homo sapiens_hsa005110.29028644
97Alcoholism_Homo sapiens_hsa050340.28203249
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27882868
99Fatty acid degradation_Homo sapiens_hsa000710.27165009
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26768881
101beta-Alanine metabolism_Homo sapiens_hsa004100.26749594
102Antigen processing and presentation_Homo sapiens_hsa046120.26312059
103MicroRNAs in cancer_Homo sapiens_hsa052060.25512961
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24589227
105Cardiac muscle contraction_Homo sapiens_hsa042600.24529182
106* Oocyte meiosis_Homo sapiens_hsa041140.24393503
107Viral carcinogenesis_Homo sapiens_hsa052030.24329111
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24252890
109Retinol metabolism_Homo sapiens_hsa008300.23138921
110N-Glycan biosynthesis_Homo sapiens_hsa005100.23068028
111Carbon metabolism_Homo sapiens_hsa012000.21720641
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21518306
113Basal cell carcinoma_Homo sapiens_hsa052170.21083562
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19861190
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.19602527
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18926037
117Notch signaling pathway_Homo sapiens_hsa043300.18756788
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18593171
119Vitamin digestion and absorption_Homo sapiens_hsa049770.17850993
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17255338
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17079266
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16984668
123* HTLV-I infection_Homo sapiens_hsa051660.16969074
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16650162
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15663417
126Phagosome_Homo sapiens_hsa041450.14783363
127Histidine metabolism_Homo sapiens_hsa003400.14336622

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