ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingoid metabolic process (GO:0046519)	8.18790215
2	sphingosine metabolic process (GO:0006670)	7.76897812
3	diol metabolic process (GO:0034311)	7.37888686
4	DNA methylation involved in gamete generation (GO:0043046)	5.99961780
5	protein-chromophore linkage (GO:0018298)	5.85829479
6	piRNA metabolic process (GO:0034587)	5.65065609
7	regulation of pigment cell differentiation (GO:0050932)	5.39206536
8	indolalkylamine metabolic process (GO:0006586)	4.98148328
9	positive regulation of developmental pigmentation (GO:0048087)	4.93731358
10	regulation of hippo signaling (GO:0035330)	4.82466320
11	regulation of meiosis I (GO:0060631)	4.77543721
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.71669697
13	sulfate transmembrane transport (GO:1902358)	4.57554539
14	tachykinin receptor signaling pathway (GO:0007217)	4.50515263
15	cilium or flagellum-dependent cell motility (GO:0001539)	4.38227717
16	regulation of gene silencing by RNA (GO:0060966)	4.31318929
17	regulation of posttranscriptional gene silencing (GO:0060147)	4.31318929
18	regulation of gene silencing by miRNA (GO:0060964)	4.31318929
19	indole-containing compound catabolic process (GO:0042436)	4.31231532
20	indolalkylamine catabolic process (GO:0046218)	4.31231532
21	tryptophan catabolic process (GO:0006569)	4.31231532
22	sulfate transport (GO:0008272)	4.20798346
23	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	4.04893546
24	lipopolysaccharide biosynthetic process (GO:0009103)	4.00534135
25	photoreceptor cell maintenance (GO:0045494)	3.95365998
26	regulation of protein glycosylation (GO:0060049)	3.94508365
27	meiotic chromosome segregation (GO:0045132)	3.86666512
28	kynurenine metabolic process (GO:0070189)	3.85037015
29	cellular biogenic amine catabolic process (GO:0042402)	3.79177166
30	amine catabolic process (GO:0009310)	3.79177166
31	flavonoid metabolic process (GO:0009812)	3.69526820
32	opioid receptor signaling pathway (GO:0038003)	3.69516480
33	behavioral response to nicotine (GO:0035095)	3.64086585
34	aromatic amino acid family catabolic process (GO:0009074)	3.61571342
35	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.60177345
36	reflex (GO:0060004)	3.51182835
37	indole-containing compound metabolic process (GO:0042430)	3.48612982
38	positive regulation of cAMP-mediated signaling (GO:0043950)	3.48125780
39	serotonin metabolic process (GO:0042428)	3.45516793
40	rhodopsin mediated signaling pathway (GO:0016056)	3.45466902
41	aromatic amino acid family metabolic process (GO:0009072)	3.45243115
42	positive regulation of meiosis (GO:0045836)	3.45088362
43	tryptophan metabolic process (GO:0006568)	3.41822212
44	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.40984847
45	lipopolysaccharide metabolic process (GO:0008653)	3.35309300
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.31215186
47	signal peptide processing (GO:0006465)	3.29683917
48	behavioral response to ethanol (GO:0048149)	3.24697838
49	positive regulation of meiotic cell cycle (GO:0051446)	3.21220576
50	SMAD protein complex assembly (GO:0007183)	3.20578367
51	retinal cone cell development (GO:0046549)	3.19815931
52	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.18544797
53	primary amino compound metabolic process (GO:1901160)	3.15380878
54	tyrosine metabolic process (GO:0006570)	3.11328727
55	centriole replication (GO:0007099)	3.07504556
56	cellular response to sterol (GO:0036315)	3.05713799
57	fucose catabolic process (GO:0019317)	3.03501180
58	L-fucose metabolic process (GO:0042354)	3.03501180
59	L-fucose catabolic process (GO:0042355)	3.03501180
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.96445245
61	detection of light stimulus involved in visual perception (GO:0050908)	2.96445245
62	regulation of keratinocyte proliferation (GO:0010837)	2.96333776
63	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.92564922
64	sulfation (GO:0051923)	2.91715508
65	gonadal mesoderm development (GO:0007506)	2.91377310
66	phasic smooth muscle contraction (GO:0014821)	2.91349816
67	serotonin receptor signaling pathway (GO:0007210)	2.90065311
68	snRNA transcription (GO:0009301)	2.88718326
69	righting reflex (GO:0060013)	2.86400247
70	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.85700829
71	interkinetic nuclear migration (GO:0022027)	2.83228170
72	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.83203627
73	L-phenylalanine catabolic process (GO:0006559)	2.83203627
74	gene silencing by RNA (GO:0031047)	2.83109191
75	cAMP catabolic process (GO:0006198)	2.82181006
76	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.79940117
77	protein K48-linked deubiquitination (GO:0071108)	2.77867650
78	detection of mechanical stimulus (GO:0050982)	2.74420581
79	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.70047259
80	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.68345534
81	positive regulation of vascular permeability (GO:0043117)	2.68274615
82	NAD biosynthetic process (GO:0009435)	2.67962154
83	transmission of nerve impulse (GO:0019226)	2.67247429
84	benzene-containing compound metabolic process (GO:0042537)	2.65527835
85	reciprocal DNA recombination (GO:0035825)	2.63747279
86	reciprocal meiotic recombination (GO:0007131)	2.63747279
87	notochord development (GO:0030903)	2.63309755
88	heme transport (GO:0015886)	2.63229507
89	negative regulation of keratinocyte proliferation (GO:0010839)	2.61306461
90	pantothenate metabolic process (GO:0015939)	2.59563669
91	neural tube formation (GO:0001841)	2.57887190
92	monoubiquitinated protein deubiquitination (GO:0035520)	2.56834490
93	peristalsis (GO:0030432)	2.56591384
94	central nervous system neuron axonogenesis (GO:0021955)	2.56118125
95	cellular response to gamma radiation (GO:0071480)	2.55522094
96	dopamine transport (GO:0015872)	2.53853597
97	regulation of female gonad development (GO:2000194)	2.53265294
98	central nervous system projection neuron axonogenesis (GO:0021952)	2.52119253
99	cyclic nucleotide catabolic process (GO:0009214)	2.50896339
100	regulation of sarcomere organization (GO:0060297)	2.50862979

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.76595716
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.79780440
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.65184374
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.07516897
5	VDR_22108803_ChIP-Seq_LS180_Human	2.93340409
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.74877072
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.71179484
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70647510
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29290720
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27460646
11	P300_19829295_ChIP-Seq_ESCs_Human	2.13933992
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11516210
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10074968
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.99467587
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95516632
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.94789389
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.93188499
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90671760
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85453901
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83466871
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.82911462
22	STAT3_23295773_ChIP-Seq_U87_Human	1.81332871
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80485400
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79673893
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73333733
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73166826
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69877764
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69877764
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68507172
30	FUS_26573619_Chip-Seq_HEK293_Human	1.66135201
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62640064
32	TCF4_23295773_ChIP-Seq_U87_Human	1.62080228
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62035375
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58624279
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54740767
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.51774446
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.51655361
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47703255
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47703255
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45233678
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42721133
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42215614
43	AR_25329375_ChIP-Seq_VCAP_Human	1.41576891
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41163909
45	EWS_26573619_Chip-Seq_HEK293_Human	1.38140881
46	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.34890998
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.33650413
48	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.29132375
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28877999
50	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.27208034
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26980605
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26036064
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23636547
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23429644
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.22369190
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19218376
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17793120
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17787252
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17449054
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15101087
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14082800
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.14082800
63	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13948365
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13442108
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12266172
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12005478
67	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11712671
68	AR_19668381_ChIP-Seq_PC3_Human	1.09912237
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09074720
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08599863
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08356315
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08139138
73	CJUN_26792858_Chip-Seq_BT549_Human	1.07887277
74	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.07336231
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06947270
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06538949
77	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06467331
78	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.06066587
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.05193656
80	RXR_22108803_ChIP-Seq_LS180_Human	1.05026481
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04916931
82	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03222918
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02730457
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02730457
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02628395
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02619054
87	TP53_16413492_ChIP-PET_HCT116_Human	1.02044909
88	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.01039177
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99100999
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99043036
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98226963
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98223886
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98194220
94	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98081497
95	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98005155
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97834922
97	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.97701040
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97645857
99	KDM2B_26808549_Chip-Seq_REH_Human	0.97633195
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.97445785

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	7.28954364
2	MP0000569_abnormal_digit_pigmentation	5.28025604
3	MP0002837_dystrophic_cardiac_calcinosis	5.27036753
4	MP0005171_absent_coat_pigmentation	5.09096291
5	MP0003646_muscle_fatigue	3.81483685
6	MP0003045_fibrosis	3.29362815
7	MP0005085_abnormal_gallbladder_physiolo	3.13018431
8	MP0002653_abnormal_ependyma_morphology	2.98007059
9	MP0002138_abnormal_hepatobiliary_system	2.91164585
10	MP0003879_abnormal_hair_cell	2.90819016
11	MP0003890_abnormal_embryonic-extraembry	2.78277041
12	MP0005083_abnormal_biliary_tract	2.45840666
13	MP0001501_abnormal_sleep_pattern	2.40675080
14	MP0003195_calcinosis	2.36497725
15	MP0005670_abnormal_white_adipose	2.28131383
16	MP0004381_abnormal_hair_follicle	2.00483240
17	MP0004147_increased_porphyrin_level	1.86644685
18	MP0005551_abnormal_eye_electrophysiolog	1.84846290
19	MP0001968_abnormal_touch/_nociception	1.84081180
20	MP0002736_abnormal_nociception_after	1.77437928
21	MP0002735_abnormal_chemical_nociception	1.68304224
22	MP0005365_abnormal_bile_salt	1.67182336
23	MP0002938_white_spotting	1.63034128
24	MP0005174_abnormal_tail_pigmentation	1.59688521
25	MP0002168_other_aberrant_phenotype	1.57422224
26	MP0008872_abnormal_physiological_respon	1.53705050
27	MP0006276_abnormal_autonomic_nervous	1.45631991
28	MP0005423_abnormal_somatic_nervous	1.42591322
29	MP0000427_abnormal_hair_cycle	1.36502627
30	MP0009046_muscle_twitch	1.32527538
31	MP0002102_abnormal_ear_morphology	1.32187006
32	MP0003950_abnormal_plasma_membrane	1.29217032
33	MP0005646_abnormal_pituitary_gland	1.29088727
34	MP0002095_abnormal_skin_pigmentation	1.26413877
35	MP0009745_abnormal_behavioral_response	1.25157743
36	MP0005075_abnormal_melanosome_morpholog	1.24819713
37	MP0005395_other_phenotype	1.20056372
38	MP0005410_abnormal_fertilization	1.18961633
39	MP0003252_abnormal_bile_duct	1.18554162
40	MP0008004_abnormal_stomach_pH	1.16818147
41	MP0002572_abnormal_emotion/affect_behav	1.12259447
42	MP0001486_abnormal_startle_reflex	1.11149057
43	MP0003183_abnormal_peptide_metabolism	1.08960769
44	MP0008057_abnormal_DNA_replication	1.06358183
45	MP0005253_abnormal_eye_physiology	1.04825344
46	MP0004130_abnormal_muscle_cell	1.00800088
47	MP0003718_maternal_effect	0.99967165
48	MP0002272_abnormal_nervous_system	0.99597432
49	MP0001664_abnormal_digestion	0.98429374
50	MP0001485_abnormal_pinna_reflex	0.96903709
51	MP0003937_abnormal_limbs/digits/tail_de	0.96044163
52	MP0000383_abnormal_hair_follicle	0.95619341
53	MP0001970_abnormal_pain_threshold	0.95556283
54	MP0003943_abnormal_hepatobiliary_system	0.94890559
55	MP0002733_abnormal_thermal_nociception	0.90709456
56	MP0004233_abnormal_muscle_weight	0.90580984
57	MP0002160_abnormal_reproductive_system	0.90388413
58	MP0000230_abnormal_systemic_arterial	0.90210694
59	MP0004043_abnormal_pH_regulation	0.90164991
60	MP0002075_abnormal_coat/hair_pigmentati	0.89263227
61	MP0003959_abnormal_lean_body	0.88427367
62	MP0006072_abnormal_retinal_apoptosis	0.87925749
63	MP0006054_spinal_hemorrhage	0.84640250
64	MP0002064_seizures	0.84636657
65	MP0002234_abnormal_pharynx_morphology	0.84261269
66	MP0003137_abnormal_impulse_conducting	0.83326271
67	MP0001764_abnormal_homeostasis	0.82289635
68	MP0004142_abnormal_muscle_tone	0.81929119
69	MP0001324_abnormal_eye_pigmentation	0.80929388
70	MP0002928_abnormal_bile_duct	0.80070568
71	MP0008877_abnormal_DNA_methylation	0.79076731
72	MP0002876_abnormal_thyroid_physiology	0.78954128
73	MP0002067_abnormal_sensory_capabilities	0.77745825
74	MP0002229_neurodegeneration	0.75521312
75	MP0003698_abnormal_male_reproductive	0.74729349
76	MP0009053_abnormal_anal_canal	0.73836181
77	MP0005464_abnormal_platelet_physiology	0.73051438
78	MP0001963_abnormal_hearing_physiology	0.71496816
79	MP0005377_hearing/vestibular/ear_phenot	0.71476510
80	MP0003878_abnormal_ear_physiology	0.71476510
81	MP0002184_abnormal_innervation	0.71466448
82	MP0003011_delayed_dark_adaptation	0.71318416
83	MP0003635_abnormal_synaptic_transmissio	0.70790568
84	MP0000749_muscle_degeneration	0.70778804
85	MP0004742_abnormal_vestibular_system	0.70006552
86	MP0000026_abnormal_inner_ear	0.69196136
87	MP0005266_abnormal_metabolism	0.67605876
88	MP0000470_abnormal_stomach_morphology	0.67488205
89	MP0002638_abnormal_pupillary_reflex	0.66803425
90	MP0000015_abnormal_ear_pigmentation	0.66747161
91	MP0005647_abnormal_sex_gland	0.66140395
92	MP0002752_abnormal_somatic_nervous	0.63943485
93	MP0008569_lethality_at_weaning	0.60431106
94	MP0005195_abnormal_posterior_eye	0.60196161
95	MP0008875_abnormal_xenobiotic_pharmacok	0.58455655
96	MP0003705_abnormal_hypodermis_morpholog	0.57739525
97	MP0001440_abnormal_grooming_behavior	0.57658373
98	MP0000778_abnormal_nervous_system	0.54269353
99	MP0004085_abnormal_heartbeat	0.54152264
100	MP0002210_abnormal_sex_determination	0.53943740

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	5.71955700
2	Focal motor seizures (HP:0011153)	5.22227459
3	Pancreatic cysts (HP:0001737)	4.76664253
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.04118198
5	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.03114084
6	Acanthocytosis (HP:0001927)	3.71504616
7	Abnormality of the renal cortex (HP:0011035)	3.69079217
8	Cerebellar dysplasia (HP:0007033)	3.53552218
9	Attenuation of retinal blood vessels (HP:0007843)	3.32654430
10	Congenital stationary night blindness (HP:0007642)	3.30158532
11	Pancreatic fibrosis (HP:0100732)	3.29722795
12	Focal seizures (HP:0007359)	3.27078358
13	Type II lissencephaly (HP:0007260)	3.16206637
14	Congenital sensorineural hearing impairment (HP:0008527)	3.16076139
15	Tubular atrophy (HP:0000092)	3.15519689
16	Dialeptic seizures (HP:0011146)	3.13705854
17	Increased cerebral lipofuscin (HP:0011813)	3.09017594
18	True hermaphroditism (HP:0010459)	3.03841290
19	Progressive inability to walk (HP:0002505)	3.01951931
20	Abnormality of the renal medulla (HP:0100957)	2.99328607
21	Cystic liver disease (HP:0006706)	2.99107015
22	Nephronophthisis (HP:0000090)	2.98950745
23	Bony spicule pigmentary retinopathy (HP:0007737)	2.97548621
24	Keratoconus (HP:0000563)	2.93771062
25	Increased corneal curvature (HP:0100692)	2.93771062
26	Gaze-evoked nystagmus (HP:0000640)	2.91140731
27	Difficulty walking (HP:0002355)	2.90391723
28	Hematochezia (HP:0002573)	2.89467412
29	Inability to walk (HP:0002540)	2.88301313
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.86314789
31	Tubulointerstitial fibrosis (HP:0005576)	2.85244586
32	Central scotoma (HP:0000603)	2.84573938
33	Spontaneous hematomas (HP:0007420)	2.83548495
34	Abolished electroretinogram (ERG) (HP:0000550)	2.73178994
35	Polydipsia (HP:0001959)	2.68651828
36	Abnormal drinking behavior (HP:0030082)	2.68651828
37	Molar tooth sign on MRI (HP:0002419)	2.68133627
38	Abnormality of midbrain morphology (HP:0002418)	2.68133627
39	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.68076147
40	Clumsiness (HP:0002312)	2.66509998
41	Ileus (HP:0002595)	2.64725360
42	Severe visual impairment (HP:0001141)	2.64474538
43	Conjunctival telangiectasia (HP:0000524)	2.63823493
44	Colon cancer (HP:0003003)	2.52107333
45	Genetic anticipation (HP:0003743)	2.51412757
46	Decreased circulating renin level (HP:0003351)	2.41336832
47	Potter facies (HP:0002009)	2.35863544
48	Facial shape deformation (HP:0011334)	2.35863544
49	Parakeratosis (HP:0001036)	2.34756477
50	Hypoplastic iliac wings (HP:0002866)	2.34559748
51	Abnormality of macular pigmentation (HP:0008002)	2.34399746
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33532244
53	Petechiae (HP:0000967)	2.30432400
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.29574234
55	Retinal dysplasia (HP:0007973)	2.27055411
56	Enlarged kidneys (HP:0000105)	2.23936518
57	Scotoma (HP:0000575)	2.23829216
58	Febrile seizures (HP:0002373)	2.23497649
59	Hyperventilation (HP:0002883)	2.22103571
60	Pendular nystagmus (HP:0012043)	2.21546303
61	Thyroid-stimulating hormone excess (HP:0002925)	2.21294004
62	Small hand (HP:0200055)	2.20719622
63	Fair hair (HP:0002286)	2.20243042
64	Abnormal ciliary motility (HP:0012262)	2.19389524
65	Poikilocytosis (HP:0004447)	2.19147850
66	Chromsome breakage (HP:0040012)	2.18189614
67	Protruding tongue (HP:0010808)	2.18185442
68	Aplastic anemia (HP:0001915)	2.16607008
69	Congenital hepatic fibrosis (HP:0002612)	2.15584097
70	Progressive cerebellar ataxia (HP:0002073)	2.14428634
71	Large for gestational age (HP:0001520)	2.10181141
72	Abnormality of the ischium (HP:0003174)	2.06052963
73	Stomach cancer (HP:0012126)	2.03524405
74	Menorrhagia (HP:0000132)	2.03440641
75	Overlapping toe (HP:0001845)	2.03344229
76	Hyperalaninemia (HP:0003348)	2.03024805
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03024805
78	Abnormality of alanine metabolism (HP:0010916)	2.03024805
79	Congenital, generalized hypertrichosis (HP:0004540)	2.02226137
80	Hyperlipoproteinemia (HP:0010980)	1.96331544
81	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.96017257
82	Polyuria (HP:0000103)	1.94814036
83	Concave nail (HP:0001598)	1.94275447
84	Progressive visual loss (HP:0000529)	1.91468973
85	Prolonged bleeding time (HP:0003010)	1.91369426
86	Increased density of long bones (HP:0006392)	1.89635878
87	Furrowed tongue (HP:0000221)	1.88996599
88	Short foot (HP:0001773)	1.88612717
89	Retinitis pigmentosa (HP:0000510)	1.87816312
90	Abnormal albumin level (HP:0012116)	1.87517167
91	Hypoalbuminemia (HP:0003073)	1.87517167
92	Hydroxyprolinuria (HP:0003080)	1.85894687
93	Abnormality of proline metabolism (HP:0010907)	1.85894687
94	Hypoplasia of the pons (HP:0012110)	1.83964121
95	Increased mean platelet volume (HP:0011877)	1.82456724
96	Decreased central vision (HP:0007663)	1.81957716
97	Hypoplastic ischia (HP:0003175)	1.81581310
98	Optic nerve hypoplasia (HP:0000609)	1.80127179
99	Constricted visual fields (HP:0001133)	1.79875669
100	Hypokalemia (HP:0002900)	1.79119450

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	8.67012635
2	FRK	6.20838318
3	STK38L	5.04804678
4	ACVR1B	4.26610261
5	LATS2	3.41852057
6	BMPR1B	3.07084792
7	ZAK	2.78082699
8	INSRR	2.49640728
9	ADRBK2	2.47867549
10	STK3	2.00405046
11	MELK	1.75818049
12	NUAK1	1.71496716
13	PNCK	1.67269265
14	TGFBR1	1.61160837
15	STK38	1.60301266
16	NTRK3	1.53657101
17	MAP2K2	1.48616022
18	PRKD3	1.45767841
19	NME1	1.39698344
20	PIK3CG	1.38822213
21	ADRBK1	1.31772513
22	TLK1	1.26353330
23	PINK1	1.25299959
24	NLK	1.21403946
25	TAOK3	1.15860014
26	NTRK2	1.14462641
27	TAF1	1.13828055
28	GRK1	1.02482199
29	PTK2B	1.00630490
30	TEC	0.94787311
31	PRKAA2	0.93128894
32	CASK	0.89663027
33	EIF2AK3	0.87966779
34	BMX	0.84568774
35	TNK2	0.83329300
36	NEK2	0.82014816
37	CHEK2	0.81290840
38	MAP2K1	0.68296469
39	GRK5	0.62968345
40	MKNK2	0.61633824
41	STK39	0.61491971
42	OXSR1	0.60867006
43	TNIK	0.60853817
44	PRKCG	0.60169843
45	MAPK13	0.58960254
46	DAPK2	0.57069679
47	WNK3	0.55644334
48	WEE1	0.52799856
49	PRKCE	0.52425560
50	MAPKAPK3	0.52236255
51	GRK7	0.45299614
52	PKN1	0.39170032
53	CAMK2A	0.39009828
54	TXK	0.38743175
55	PDPK1	0.38035452
56	LMTK2	0.37956731
57	PIM1	0.36115417
58	TIE1	0.34204074
59	PIM2	0.33894410
60	RPS6KB2	0.32681627
61	ERBB3	0.28777888
62	CDC7	0.27124851
63	MUSK	0.24810737
64	NEK9	0.24349368
65	PRKACA	0.23435955
66	MAPK15	0.22858030
67	BRD4	0.22487626
68	ERBB4	0.22426107
69	PRKD1	0.22267185
70	WNK4	0.21979800
71	MAP3K4	0.21471439
72	FLT3	0.21139366
73	CSF1R	0.20111356
74	PLK1	0.19296933
75	CSNK1D	0.18674659
76	KIT	0.18569448
77	PRKACB	0.18422576
78	PHKG1	0.16282561
79	PHKG2	0.16282561
80	CSNK1A1L	0.16191136
81	STK11	0.16119022
82	MAP3K7	0.15707272
83	PRKCB	0.15699840
84	PRKCI	0.14935409
85	MYLK	0.14688941
86	RPS6KA6	0.14611769
87	MAPK3	0.14586554
88	VRK1	0.14352876
89	MAP3K2	0.14300065
90	MAPKAPK5	0.14246420
91	PRKCH	0.14125039
92	IRAK3	0.14114380
93	AKT2	0.13425508
94	AKT1	0.11980525
95	PRKG2	0.10912448
96	AKT3	0.10641132
97	PRKCA	0.09192773
98	SYK	0.08988100
99	MARK3	0.08730169
100	CDK12	0.08528034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.49518249
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.88617331
3	Nicotine addiction_Homo sapiens_hsa05033	2.78000199
4	Sphingolipid metabolism_Homo sapiens_hsa00600	2.75009434
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.67527767
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.52958612
7	ABC transporters_Homo sapiens_hsa02010	2.39749216
8	Taste transduction_Homo sapiens_hsa04742	2.39187158
9	Morphine addiction_Homo sapiens_hsa05032	2.36840491
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.22706522
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.15321925
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.09035460
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04721726
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03085768
15	Butanoate metabolism_Homo sapiens_hsa00650	1.98878020
16	Histidine metabolism_Homo sapiens_hsa00340	1.82806892
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80900947
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.80571404
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.75442160
20	Olfactory transduction_Homo sapiens_hsa04740	1.67079843
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66325427
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.65807972
23	Serotonergic synapse_Homo sapiens_hsa04726	1.63278198
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.63244686
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.61644983
26	One carbon pool by folate_Homo sapiens_hsa00670	1.55944831
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.53829761
28	GABAergic synapse_Homo sapiens_hsa04727	1.42489545
29	Salivary secretion_Homo sapiens_hsa04970	1.40032109
30	Circadian entrainment_Homo sapiens_hsa04713	1.34892094
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.34408268
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32925182
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.31602169
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28564144
35	Homologous recombination_Homo sapiens_hsa03440	1.27168135
36	Bile secretion_Homo sapiens_hsa04976	1.18484460
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18248788
38	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.17751220
39	Retinol metabolism_Homo sapiens_hsa00830	1.16877917
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14760539
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10216642
42	Platelet activation_Homo sapiens_hsa04611	1.10172971
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08998462
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.08350231
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04623735
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01902764
47	ECM-receptor interaction_Homo sapiens_hsa04512	0.97854226
48	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.93004771
49	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.91847024
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91492922
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.88858514
52	Long-term depression_Homo sapiens_hsa04730	0.87015872
53	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.87004384
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.86880000
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83388200
56	Gastric acid secretion_Homo sapiens_hsa04971	0.80293139
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79165279
58	Lysine degradation_Homo sapiens_hsa00310	0.78151169
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77907294
60	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74761531
61	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.73519058
62	Fatty acid degradation_Homo sapiens_hsa00071	0.73395416
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.72418375
64	Caffeine metabolism_Homo sapiens_hsa00232	0.65970948
65	Basal transcription factors_Homo sapiens_hsa03022	0.60351251
66	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59900832
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59822200
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57708575
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57593304
70	Pancreatic secretion_Homo sapiens_hsa04972	0.57548252
71	Insulin secretion_Homo sapiens_hsa04911	0.56382916
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56213409
73	Cholinergic synapse_Homo sapiens_hsa04725	0.55652701
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.55197640
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51797841
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48700938
77	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44286737
78	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.43730530
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43432986
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43204144
81	Renin secretion_Homo sapiens_hsa04924	0.42863220
82	Purine metabolism_Homo sapiens_hsa00230	0.42557458
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41822738
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.41551537
85	Alcoholism_Homo sapiens_hsa05034	0.40508656
86	Circadian rhythm_Homo sapiens_hsa04710	0.39641880
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39317287
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37351297
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.36157569
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32655132
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30506612
92	African trypanosomiasis_Homo sapiens_hsa05143	0.29864630
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28528083
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27470818
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26762820
96	Gap junction_Homo sapiens_hsa04540	0.25728860
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.22431837
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.20759415
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.20662554
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.20655324

CDC27P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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