ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	7.36485871
2	diol metabolic process (GO:0034311)	6.56872149
3	meiotic chromosome segregation (GO:0045132)	6.51242656
4	behavioral response to nicotine (GO:0035095)	6.37740752
5	sphingoid metabolic process (GO:0046519)	6.34846510
6	positive regulation of meiosis (GO:0045836)	5.23459881
7	regulation of meiosis I (GO:0060631)	4.96668774
8	positive regulation of meiotic cell cycle (GO:0051446)	4.84202144
9	piRNA metabolic process (GO:0034587)	4.60868440
10	response to pheromone (GO:0019236)	4.55308094
11	negative regulation of telomere maintenance (GO:0032205)	4.52153089
12	DNA methylation involved in gamete generation (GO:0043046)	4.49607635
13	sulfate transmembrane transport (GO:1902358)	4.40685992
14	DNA deamination (GO:0045006)	4.35993736
15	neurotransmitter metabolic process (GO:0042133)	4.29942311
16	protein-chromophore linkage (GO:0018298)	4.19929978
17	organic cation transport (GO:0015695)	4.18072394
18	sulfate transport (GO:0008272)	4.17450302
19	neurotransmitter biosynthetic process (GO:0042136)	4.14811429
20	kynurenine metabolic process (GO:0070189)	4.10053591
21	drug transmembrane transport (GO:0006855)	4.04099587
22	lipopolysaccharide biosynthetic process (GO:0009103)	4.01531527
23	reciprocal DNA recombination (GO:0035825)	3.88336547
24	reciprocal meiotic recombination (GO:0007131)	3.88336547
25	indole-containing compound catabolic process (GO:0042436)	3.82187065
26	indolalkylamine catabolic process (GO:0046218)	3.82187065
27	tryptophan catabolic process (GO:0006569)	3.82187065
28	rRNA catabolic process (GO:0016075)	3.78317542
29	sulfation (GO:0051923)	3.73886208
30	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.65151734
31	histamine transport (GO:0051608)	3.62464513
32	exogenous drug catabolic process (GO:0042738)	3.60525626
33	aromatic amino acid family catabolic process (GO:0009074)	3.59318042
34	resolution of meiotic recombination intermediates (GO:0000712)	3.56429077
35	histone-serine phosphorylation (GO:0035404)	3.53572238
36	cilium or flagellum-dependent cell motility (GO:0001539)	3.53338331
37	indolalkylamine metabolic process (GO:0006586)	3.50086036
38	cellular ketone body metabolic process (GO:0046950)	3.41936957
39	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.34909333
40	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.34687418
41	adaptation of signaling pathway (GO:0023058)	3.34461131
42	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.33590392
43	L-phenylalanine catabolic process (GO:0006559)	3.33590392
44	C4-dicarboxylate transport (GO:0015740)	3.31859417
45	lipopolysaccharide metabolic process (GO:0008653)	3.31504265
46	protein K11-linked deubiquitination (GO:0035871)	3.29082091
47	positive regulation of fatty acid oxidation (GO:0046321)	3.27635907
48	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.26282241
49	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.26147840
50	sulfur compound transport (GO:0072348)	3.25353162
51	regulation of pigment cell differentiation (GO:0050932)	3.22170192
52	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.17267164
53	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.16542347
54	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.11656277
55	regulation of protein glycosylation (GO:0060049)	3.11583679
56	drug catabolic process (GO:0042737)	3.08617381
57	auditory receptor cell stereocilium organization (GO:0060088)	3.07586712
58	ketone body metabolic process (GO:1902224)	3.03995122
59	flavonoid metabolic process (GO:0009812)	3.03133162
60	negative regulation by host of viral transcription (GO:0043922)	3.02957699
61	tryptophan metabolic process (GO:0006568)	3.02381207
62	gamma-aminobutyric acid transport (GO:0015812)	3.01138360
63	positive regulation of developmental pigmentation (GO:0048087)	2.98250593
64	quaternary ammonium group transport (GO:0015697)	2.96405477
65	tooth mineralization (GO:0034505)	2.96287269
66	cornea development in camera-type eye (GO:0061303)	2.96261334
67	rhodopsin mediated signaling pathway (GO:0016056)	2.96016587
68	gonadal mesoderm development (GO:0007506)	2.95567338
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.95155632
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.91848881
71	aromatic amino acid family metabolic process (GO:0009072)	2.88250207
72	regulation of activation of Janus kinase activity (GO:0010533)	2.87486923
73	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.86972303
74	detection of light stimulus involved in sensory perception (GO:0050962)	2.85473695
75	detection of light stimulus involved in visual perception (GO:0050908)	2.85473695
76	regulation of B cell receptor signaling pathway (GO:0050855)	2.83957558
77	primary amino compound metabolic process (GO:1901160)	2.82107558
78	fucose catabolic process (GO:0019317)	2.80794267
79	L-fucose metabolic process (GO:0042354)	2.80794267
80	L-fucose catabolic process (GO:0042355)	2.80794267
81	proline transport (GO:0015824)	2.80203961
82	coenzyme catabolic process (GO:0009109)	2.79840359
83	cellular biogenic amine catabolic process (GO:0042402)	2.75844845
84	amine catabolic process (GO:0009310)	2.75844845
85	indole-containing compound metabolic process (GO:0042430)	2.74856544
86	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.69971009
87	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.69606954
88	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.69136373
89	regulation of natural killer cell mediated immunity (GO:0002715)	2.69136373
90	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.68703044
91	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.67976010
92	cytidine deamination (GO:0009972)	2.65575777
93	cytidine metabolic process (GO:0046087)	2.65575777
94	cytidine catabolic process (GO:0006216)	2.65575777
95	tachykinin receptor signaling pathway (GO:0007217)	2.62750934
96	signal peptide processing (GO:0006465)	2.60738454
97	synaptonemal complex assembly (GO:0007130)	2.59764087
98	azole transport (GO:0045117)	2.58980387
99	cellular response to exogenous dsRNA (GO:0071360)	2.58917330
100	tyrosine metabolic process (GO:0006570)	2.58554958

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.37706067
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.56277704
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41407411
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96518996
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.76552187
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.48877450
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.37152383
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.34829450
9	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.29167809
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.14891365
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12470925
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10988267
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.03027361
14	NANOG_19829295_ChIP-Seq_ESCs_Human	1.91245083
15	SOX2_19829295_ChIP-Seq_ESCs_Human	1.91245083
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.89479596
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82612946
18	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.78254057
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.77320116
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73716180
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73047723
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72854378
23	P300_19829295_ChIP-Seq_ESCs_Human	1.72482318
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70192441
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.62550485
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61328283
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.56860860
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.55887880
29	NCOR_22424771_ChIP-Seq_293T_Human	1.46304139
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.44244007
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.44212351
32	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.44202379
33	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.43083193
34	TCF4_23295773_ChIP-Seq_U87_Human	1.41746621
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37518866
36	STAT3_23295773_ChIP-Seq_U87_Human	1.36302226
37	AR_25329375_ChIP-Seq_VCAP_Human	1.36281914
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.35703825
39	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.34628000
40	OCT4_20526341_ChIP-Seq_ESCs_Human	1.34607186
41	HOXB7_26014856_ChIP-Seq_BT474_Human	1.33738918
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32106160
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31306435
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29682588
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29497009
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29497009
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28095663
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24741380
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23194085
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22296428
51	RAC3_21632823_ChIP-Seq_H3396_Human	1.21979182
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21533377
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21336249
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.21336249
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.20822457
56	AR_20517297_ChIP-Seq_VCAP_Human	1.20735771
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20353327
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19951511
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.19866228
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19251369
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18413318
62	EWS_26573619_Chip-Seq_HEK293_Human	1.18275038
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17859861
64	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.17361103
65	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17161983
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.16798541
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16623205
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16043326
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15672883
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15672883
71	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13993657
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13021434
73	FUS_26573619_Chip-Seq_HEK293_Human	1.12531709
74	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12414131
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.12293505
76	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11887168
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11862434
78	CEBPB_22108803_ChIP-Seq_LS180_Human	1.10693486
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10685591
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09836835
81	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09492961
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09348002
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.08298231
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07352336
85	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.07129743
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06542555
87	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06516628
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05637363
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04913915
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04700577
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.03751095
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02224741
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01645456
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01582262
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01559568
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01263432
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00795455
98	BCAT_22108803_ChIP-Seq_LS180_Human	1.00282326
99	ERA_21632823_ChIP-Seq_H3396_Human	1.00134021
100	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99740134

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.86205437
2	MP0002837_dystrophic_cardiac_calcinosis	5.63186514
3	MP0003646_muscle_fatigue	4.94563115
4	MP0005171_absent_coat_pigmentation	3.40436125
5	MP0003045_fibrosis	2.96949390
6	MP0003806_abnormal_nucleotide_metabolis	2.94200853
7	MP0003195_calcinosis	2.54045330
8	MP0002653_abnormal_ependyma_morphology	2.48999830
9	MP0005085_abnormal_gallbladder_physiolo	2.47110247
10	MP0001501_abnormal_sleep_pattern	2.33202285
11	MP0005551_abnormal_eye_electrophysiolog	2.31286095
12	MP0004381_abnormal_hair_follicle	2.19752101
13	MP0004147_increased_porphyrin_level	2.15998429
14	MP0008872_abnormal_physiological_respon	2.03827798
15	MP0002138_abnormal_hepatobiliary_system	1.99473287
16	MP0004043_abnormal_pH_regulation	1.88311265
17	MP0001968_abnormal_touch/_nociception	1.85025901
18	MP0003879_abnormal_hair_cell	1.84212580
19	MP0001873_stomach_inflammation	1.82651222
20	MP0005365_abnormal_bile_salt	1.81151614
21	MP0002160_abnormal_reproductive_system	1.80388554
22	MP0003011_delayed_dark_adaptation	1.79731055
23	MP0005671_abnormal_response_to	1.77663666
24	MP0008875_abnormal_xenobiotic_pharmacok	1.71166874
25	MP0005410_abnormal_fertilization	1.60499642
26	MP0000372_irregular_coat_pigmentation	1.54398803
27	MP0006276_abnormal_autonomic_nervous	1.48884661
28	MP0004142_abnormal_muscle_tone	1.47770185
29	MP0005670_abnormal_white_adipose	1.47573214
30	MP0009745_abnormal_behavioral_response	1.44589844
31	MP0009046_muscle_twitch	1.42875784
32	MP0005645_abnormal_hypothalamus_physiol	1.40440580
33	MP0002909_abnormal_adrenal_gland	1.40338338
34	MP0002733_abnormal_thermal_nociception	1.40037061
35	MP0003137_abnormal_impulse_conducting	1.38451600
36	MP0002168_other_aberrant_phenotype	1.36134475
37	MP0005167_abnormal_blood-brain_barrier	1.32412205
38	MP0002736_abnormal_nociception_after	1.27841963
39	MP0005389_reproductive_system_phenotype	1.25706453
40	MP0005075_abnormal_melanosome_morpholog	1.25633613
41	MP0000569_abnormal_digit_pigmentation	1.22372424
42	MP0005253_abnormal_eye_physiology	1.20280530
43	MP0004145_abnormal_muscle_electrophysio	1.17510887
44	MP0000427_abnormal_hair_cycle	1.17029945
45	MP0002938_white_spotting	1.16951101
46	MP0006072_abnormal_retinal_apoptosis	1.14662484
47	MP0003252_abnormal_bile_duct	1.13690974
48	MP0001970_abnormal_pain_threshold	1.13038427
49	MP0001986_abnormal_taste_sensitivity	1.12067424
50	MP0004742_abnormal_vestibular_system	1.11563496
51	MP0001486_abnormal_startle_reflex	1.10431995
52	MP0003890_abnormal_embryonic-extraembry	1.09616370
53	MP0005360_urolithiasis	1.07129209
54	MP0002095_abnormal_skin_pigmentation	1.05811191
55	MP0002272_abnormal_nervous_system	1.05030311
56	MP0001485_abnormal_pinna_reflex	1.03772173
57	MP0001664_abnormal_digestion	1.03610840
58	MP0001764_abnormal_homeostasis	1.03494830
59	MP0002735_abnormal_chemical_nociception	1.03383645
60	MP0004130_abnormal_muscle_cell	1.01539347
61	MP0002102_abnormal_ear_morphology	0.99830845
62	MP0001963_abnormal_hearing_physiology	0.98270587
63	MP0002064_seizures	0.96904771
64	MP0002638_abnormal_pupillary_reflex	0.93336465
65	MP0005266_abnormal_metabolism	0.92081400
66	MP0004019_abnormal_vitamin_homeostasis	0.89009892
67	MP0010386_abnormal_urinary_bladder	0.86873811
68	MP0002163_abnormal_gland_morphology	0.86769490
69	MP0002572_abnormal_emotion/affect_behav	0.86249130
70	MP0002277_abnormal_respiratory_mucosa	0.85281033
71	MP0000230_abnormal_systemic_arterial	0.84402835
72	MP0002876_abnormal_thyroid_physiology	0.83877416
73	MP0008877_abnormal_DNA_methylation	0.83368079
74	MP0001919_abnormal_reproductive_system	0.83065457
75	MP0003698_abnormal_male_reproductive	0.82409335
76	MP0005395_other_phenotype	0.82198945
77	MP0006036_abnormal_mitochondrial_physio	0.81914086
78	MP0002210_abnormal_sex_determination	0.80578859
79	MP0005084_abnormal_gallbladder_morpholo	0.77714037
80	MP0001800_abnormal_humoral_immune	0.75400399
81	MP0003763_abnormal_thymus_physiology	0.75183695
82	MP0005646_abnormal_pituitary_gland	0.74612468
83	MP0004233_abnormal_muscle_weight	0.73370186
84	MP0002229_neurodegeneration	0.72335611
85	MP0003183_abnormal_peptide_metabolism	0.71806595
86	MP0005195_abnormal_posterior_eye	0.70993304
87	MP0009764_decreased_sensitivity_to	0.70164949
88	MP0010329_abnormal_lipoprotein_level	0.69338201
89	MP0005174_abnormal_tail_pigmentation	0.69258124
90	MP0005377_hearing/vestibular/ear_phenot	0.67018043
91	MP0003878_abnormal_ear_physiology	0.67018043
92	MP0000631_abnormal_neuroendocrine_gland	0.66894124
93	MP0005448_abnormal_energy_balance	0.66759082
94	MP0000015_abnormal_ear_pigmentation	0.66669350
95	MP0003638_abnormal_response/metabolism_	0.66426100
96	MP0006082_CNS_inflammation	0.65813515
97	MP0001440_abnormal_grooming_behavior	0.63924838
98	MP0002693_abnormal_pancreas_physiology	0.63822160
99	MP0003718_maternal_effect	0.62905195
100	MP0001790_abnormal_immune_system	0.62524159

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bilateral microphthalmos (HP:0007633)	4.37940040
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.35932177
3	Hypoplasia of the fovea (HP:0007750)	4.35932177
4	Amelogenesis imperfecta (HP:0000705)	4.22029891
5	Unilateral renal agenesis (HP:0000122)	4.21546531
6	Pancreatic cysts (HP:0001737)	3.82959874
7	Aplastic anemia (HP:0001915)	3.81939664
8	Abnormality of the renal cortex (HP:0011035)	3.78477048
9	Progressive inability to walk (HP:0002505)	3.68151029
10	Decreased central vision (HP:0007663)	3.48844511
11	Focal motor seizures (HP:0011153)	3.45717240
12	Abnormality of the fovea (HP:0000493)	3.45195804
13	Abolished electroretinogram (ERG) (HP:0000550)	3.27442134
14	Pendular nystagmus (HP:0012043)	3.21613430
15	Tubular atrophy (HP:0000092)	3.21604193
16	3-Methylglutaconic aciduria (HP:0003535)	3.19713344
17	Increased corneal curvature (HP:0100692)	3.12520439
18	Keratoconus (HP:0000563)	3.12520439
19	Attenuation of retinal blood vessels (HP:0007843)	3.07192438
20	Congenital stationary night blindness (HP:0007642)	3.06862127
21	Conjugated hyperbilirubinemia (HP:0002908)	3.04163040
22	Nephronophthisis (HP:0000090)	3.01914665
23	True hermaphroditism (HP:0010459)	3.01493353
24	Inability to walk (HP:0002540)	2.95381707
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.93518517
26	Abnormality of midbrain morphology (HP:0002418)	2.90100369
27	Molar tooth sign on MRI (HP:0002419)	2.90100369
28	Pancreatic fibrosis (HP:0100732)	2.79800391
29	Severe visual impairment (HP:0001141)	2.75086122
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.68401910
31	Abnormality of the renal medulla (HP:0100957)	2.66330150
32	Abnormal drinking behavior (HP:0030082)	2.62510610
33	Polydipsia (HP:0001959)	2.62510610
34	Lissencephaly (HP:0001339)	2.61867758
35	Aplasia/Hypoplasia of the macula (HP:0008059)	2.60224274
36	Hypoalbuminemia (HP:0003073)	2.58601089
37	Abnormal albumin level (HP:0012116)	2.58601089
38	Tubulointerstitial fibrosis (HP:0005576)	2.56460936
39	Colon cancer (HP:0003003)	2.53006201
40	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.50960456
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.49583355
42	Gaze-evoked nystagmus (HP:0000640)	2.47484976
43	Parakeratosis (HP:0001036)	2.45527055
44	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.43169759
45	Decreased circulating renin level (HP:0003351)	2.40158642
46	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.35169529
47	Cystic liver disease (HP:0006706)	2.32219998
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27541971
49	Hypoproteinemia (HP:0003075)	2.27280233
50	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.25569920
51	Type I transferrin isoform profile (HP:0003642)	2.24592301
52	Type II lissencephaly (HP:0007260)	2.22204006
53	Congenital hepatic fibrosis (HP:0002612)	2.16719479
54	Hydroxyprolinuria (HP:0003080)	2.16580729
55	Abnormality of proline metabolism (HP:0010907)	2.16580729
56	Cerebellar dysplasia (HP:0007033)	2.15454750
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11564555
58	Autoimmune hemolytic anemia (HP:0001890)	2.10442969
59	Renal cortical cysts (HP:0000803)	2.07440669
60	CNS hypomyelination (HP:0003429)	2.03431603
61	Central scotoma (HP:0000603)	2.02955136
62	Abnormal protein glycosylation (HP:0012346)	2.01256846
63	Abnormal glycosylation (HP:0012345)	2.01256846
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01256846
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.01256846
66	Furrowed tongue (HP:0000221)	2.01246257
67	IgG deficiency (HP:0004315)	1.98136402
68	Sensory axonal neuropathy (HP:0003390)	1.97507710
69	Hyperglycinuria (HP:0003108)	1.96146108
70	Polyuria (HP:0000103)	1.96135674
71	Abnormality of alanine metabolism (HP:0010916)	1.95317595
72	Hyperalaninemia (HP:0003348)	1.95317595
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95317595
74	Progressive cerebellar ataxia (HP:0002073)	1.93545565
75	Abnormality of macular pigmentation (HP:0008002)	1.93380219
76	Stomach cancer (HP:0012126)	1.93335375
77	Increased cerebral lipofuscin (HP:0011813)	1.88173102
78	Abnormality of transition element cation homeostasis (HP:0011030)	1.86551999
79	Concave nail (HP:0001598)	1.86118960
80	Abnormality of the pons (HP:0007361)	1.85234021
81	Radial bowing (HP:0002986)	1.83714788
82	Constricted visual fields (HP:0001133)	1.83256012
83	Hypoplasia of the pons (HP:0012110)	1.82385154
84	Generalized aminoaciduria (HP:0002909)	1.81942218
85	Severe muscular hypotonia (HP:0006829)	1.81741852
86	Acanthocytosis (HP:0001927)	1.81703895
87	Macular degeneration (HP:0000608)	1.80313230
88	Cerebral palsy (HP:0100021)	1.76750169
89	Partial agenesis of the corpus callosum (HP:0001338)	1.73459447
90	Retinitis pigmentosa (HP:0000510)	1.72808855
91	Abnormal rod and cone electroretinograms (HP:0008323)	1.72534908
92	Thyroid-stimulating hormone excess (HP:0002925)	1.72436352
93	Aplasia cutis congenita (HP:0001057)	1.72212652
94	Abnormality of the prostate (HP:0008775)	1.70939113
95	Photophobia (HP:0000613)	1.70604741
96	Clumsiness (HP:0002312)	1.70389188
97	Mixed hearing impairment (HP:0000410)	1.70270989
98	Pigmentary retinal degeneration (HP:0001146)	1.69836914
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68883649
100	Short tibia (HP:0005736)	1.68513880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	4.93591598
2	STK38L	4.40739656
3	FRK	4.23700778
4	ZAK	3.26997486
5	TXK	3.08766161
6	ACVR1B	3.07476076
7	RIPK4	2.94906040
8	TLK1	2.94789991
9	PINK1	2.79219084
10	ADRBK2	2.69461843
11	LATS2	2.57103336
12	PRKD3	2.21910078
13	BMPR2	2.13725971
14	STK38	1.99459147
15	BMPR1B	1.95616506
16	MELK	1.88092781
17	DAPK2	1.87308352
18	INSRR	1.74919855
19	KDR	1.61508468
20	NME1	1.59376144
21	LIMK1	1.49420349
22	NEK2	1.45253871
23	GRK1	1.40178527
24	TAF1	1.34561736
25	MAP3K7	1.32216186
26	VRK2	1.31044410
27	STK3	1.29315654
28	PRKAA2	1.24423843
29	VRK1	1.20000372
30	DAPK1	1.18711408
31	MAP2K2	1.18193957
32	CDK19	1.16671545
33	ADRBK1	1.14616286
34	MAP3K4	1.12107752
35	ITK	1.07009938
36	TIE1	1.06485077
37	TRPM7	1.04963028
38	BCKDK	1.02694181
39	WNK3	1.00055666
40	TAOK3	0.98186643
41	NUAK1	0.93648490
42	TEC	0.93303917
43	STK11	0.92094908
44	MAPKAPK5	0.91650531
45	MAPKAPK3	0.89506959
46	PIK3CG	0.85925127
47	ERBB3	0.83544328
48	PTK2B	0.81076689
49	NLK	0.76012601
50	ERBB2	0.75179487
51	CAMKK2	0.73401895
52	SYK	0.72681002
53	WNK4	0.71553728
54	MAPK13	0.70979146
55	BTK	0.69898702
56	OXSR1	0.67412867
57	MAP3K11	0.66610971
58	PRKCG	0.62709291
59	TGFBR1	0.59791117
60	GRK5	0.58496036
61	MAP4K1	0.56039844
62	GRK7	0.55720713
63	CAMK1	0.52946425
64	NEK9	0.51104672
65	MAP2K1	0.49748275
66	SIK2	0.49233164
67	TNK2	0.48921229
68	PRKCQ	0.48231996
69	MAP3K12	0.47768338
70	MAP3K2	0.46961941
71	MAP4K2	0.46276149
72	TESK2	0.44455092
73	CSNK1A1L	0.43972428
74	PRKAA1	0.43546512
75	SIK3	0.41878570
76	PLK4	0.41148255
77	CAMK2A	0.40434087
78	PIK3CA	0.40239687
79	PRKCE	0.39614118
80	CHEK2	0.37955960
81	CSF1R	0.36893738
82	PRKCH	0.36843003
83	BCR	0.35647080
84	RPS6KA5	0.35181886
85	BMX	0.34243558
86	PRKCA	0.32991610
87	PRKACA	0.31978262
88	PDPK1	0.31466464
89	PLK1	0.31419812
90	EIF2AK3	0.30717162
91	PRKCB	0.29453846
92	PIM1	0.25028161
93	EPHA4	0.24600052
94	PKN1	0.23966072
95	CAMK4	0.23217680
96	CSNK1D	0.21749301
97	EIF2AK1	0.21656333
98	PRKCI	0.21648331
99	LCK	0.21492354
100	MYLK	0.21305315

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.69404026
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.79047971
3	Olfactory transduction_Homo sapiens_hsa04740	2.78622247
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41054564
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31557221
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29401132
7	Nicotine addiction_Homo sapiens_hsa05033	2.24373031
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.04797694
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00317911
10	Butanoate metabolism_Homo sapiens_hsa00650	1.97120049
11	Histidine metabolism_Homo sapiens_hsa00340	1.95779858
12	Sphingolipid metabolism_Homo sapiens_hsa00600	1.93910857
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.90596153
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.85875541
15	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.83740549
16	Taste transduction_Homo sapiens_hsa04742	1.80186449
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.80030405
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.79265682
19	ABC transporters_Homo sapiens_hsa02010	1.78685952
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.77253827
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74531085
22	One carbon pool by folate_Homo sapiens_hsa00670	1.73539825
23	Morphine addiction_Homo sapiens_hsa05032	1.71287663
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.66102455
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.63730376
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57793538
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.54175700
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.46525700
29	Retinol metabolism_Homo sapiens_hsa00830	1.41036356
30	Homologous recombination_Homo sapiens_hsa03440	1.37622228
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36326668
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.30557451
33	GABAergic synapse_Homo sapiens_hsa04727	1.27883062
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.26404740
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.22109766
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19213532
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.18641318
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.17824268
39	Basal transcription factors_Homo sapiens_hsa03022	1.16046664
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13684259
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13632944
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.12456888
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.11214451
44	Sulfur relay system_Homo sapiens_hsa04122	1.08430811
45	Peroxisome_Homo sapiens_hsa04146	1.05932086
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05479626
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.02750577
48	Glutamatergic synapse_Homo sapiens_hsa04724	1.00830315
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99896584
50	Salivary secretion_Homo sapiens_hsa04970	0.98278590
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96173473
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96060044
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.94161454
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.94118178
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90033603
56	Serotonergic synapse_Homo sapiens_hsa04726	0.88120967
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86177886
58	Circadian entrainment_Homo sapiens_hsa04713	0.84080774
59	Propanoate metabolism_Homo sapiens_hsa00640	0.80793117
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.80053750
61	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75480061
62	Caffeine metabolism_Homo sapiens_hsa00232	0.75370231
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74777972
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72828956
65	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.72794831
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71742223
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69861809
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68981854
69	Allograft rejection_Homo sapiens_hsa05330	0.66854391
70	RNA polymerase_Homo sapiens_hsa03020	0.65591639
71	Purine metabolism_Homo sapiens_hsa00230	0.62952881
72	Parkinsons disease_Homo sapiens_hsa05012	0.62648278
73	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61934051
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61410462
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59965776
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59464699
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59272492
78	Huntingtons disease_Homo sapiens_hsa05016	0.56955745
79	Antigen processing and presentation_Homo sapiens_hsa04612	0.55625257
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55605622
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55334924
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.53713612
83	Bile secretion_Homo sapiens_hsa04976	0.53131470
84	Fatty acid elongation_Homo sapiens_hsa00062	0.52405768
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52157066
86	Mineral absorption_Homo sapiens_hsa04978	0.50935380
87	Metabolic pathways_Homo sapiens_hsa01100	0.50634113
88	African trypanosomiasis_Homo sapiens_hsa05143	0.49433326
89	Regulation of autophagy_Homo sapiens_hsa04140	0.48506119
90	Circadian rhythm_Homo sapiens_hsa04710	0.47142572
91	Insulin secretion_Homo sapiens_hsa04911	0.45112909
92	Alzheimers disease_Homo sapiens_hsa05010	0.44965609
93	RNA degradation_Homo sapiens_hsa03018	0.44298298
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44253326
95	Gastric acid secretion_Homo sapiens_hsa04971	0.42309911
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41690793
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40005020
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38880390
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.38502305
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.37446786

CDC27P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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