CDC37L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.20783084
2axon ensheathment in central nervous system (GO:0032291)9.20783084
3fatty acid elongation (GO:0030497)5.43825594
4myelination (GO:0042552)5.42798680
5axon ensheathment (GO:0008366)5.40601199
6ensheathment of neurons (GO:0007272)5.40601199
7regulation of meiosis I (GO:0060631)5.25410248
8myelin maintenance (GO:0043217)4.65625779
9cytoplasmic mRNA processing body assembly (GO:0033962)4.40428614
10creatine metabolic process (GO:0006600)4.31720514
11negative regulation of protein localization to cell surface (GO:2000009)4.29145509
12response to methylmercury (GO:0051597)4.22585313
13L-amino acid import (GO:0043092)4.19637075
14establishment of mitochondrion localization (GO:0051654)4.17024225
15negative regulation of neurotransmitter secretion (GO:0046929)3.96438387
16long-chain fatty acid biosynthetic process (GO:0042759)3.82406654
17actin-myosin filament sliding (GO:0033275)3.79711321
18muscle filament sliding (GO:0030049)3.79711321
19photoreceptor cell differentiation (GO:0046530)3.77893361
20eye photoreceptor cell differentiation (GO:0001754)3.77893361
21negative regulation of neurotransmitter transport (GO:0051589)3.74088320
22lipid particle organization (GO:0034389)3.63630682
23L-methionine salvage (GO:0071267)3.63380952
24L-methionine biosynthetic process (GO:0071265)3.63380952
25amino acid salvage (GO:0043102)3.63380952
26glycerophospholipid catabolic process (GO:0046475)3.60565726
27asymmetric protein localization (GO:0008105)3.54702210
28piRNA metabolic process (GO:0034587)3.54173931
29import into cell (GO:0098657)3.49203671
30regulation of cell communication by electrical coupling (GO:0010649)3.45699571
31apical protein localization (GO:0045176)3.45572614
32L-phenylalanine catabolic process (GO:0006559)3.44613509
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.44613509
34sex differentiation (GO:0007548)3.40698250
35amino acid import (GO:0043090)3.38764259
36myelination in peripheral nervous system (GO:0022011)3.37586545
37peripheral nervous system axon ensheathment (GO:0032292)3.37586545
38glyoxylate metabolic process (GO:0046487)3.35818042
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33936351
40actin-mediated cell contraction (GO:0070252)3.33303851
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.32099955
42membrane tubulation (GO:0097320)3.31254275
43protein neddylation (GO:0045116)3.30888112
44oligodendrocyte differentiation (GO:0048709)3.28372282
45ADP metabolic process (GO:0046031)3.22464758
46long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.16429493
47neuronal action potential propagation (GO:0019227)3.13490279
48response to redox state (GO:0051775)3.11932286
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.09147695
50oxidative demethylation (GO:0070989)3.08707588
51regulation of relaxation of muscle (GO:1901077)3.08290284
52bile acid biosynthetic process (GO:0006699)3.07388602
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.06693951
54fatty-acyl-CoA biosynthetic process (GO:0046949)3.03696280
55regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.02779817
56methionine biosynthetic process (GO:0009086)3.02403302
57methionine metabolic process (GO:0006555)3.02080835
58astrocyte development (GO:0014002)3.01172266
59regulation of lipoprotein metabolic process (GO:0050746)2.99200249
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.98172725
61regulation of sequestering of triglyceride (GO:0010889)2.96786113
62peptidyl-tyrosine autophosphorylation (GO:0038083)2.96366723
63kynurenine metabolic process (GO:0070189)2.96002151
64adult walking behavior (GO:0007628)2.95234583
65thioester biosynthetic process (GO:0035384)2.94552179
66acyl-CoA biosynthetic process (GO:0071616)2.94552179
67regulation of collateral sprouting (GO:0048670)2.93917292
68presynaptic membrane organization (GO:0097090)2.93692185
69cerebellar Purkinje cell differentiation (GO:0021702)2.91426099
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90902754
71L-phenylalanine metabolic process (GO:0006558)2.90902754
72pyrimidine nucleobase catabolic process (GO:0006208)2.90607631
73proteasome assembly (GO:0043248)2.90408857
74glycine transport (GO:0015816)2.90273602
75substantia nigra development (GO:0021762)2.89957431
76regulation of coenzyme metabolic process (GO:0051196)2.88935591
77regulation of cofactor metabolic process (GO:0051193)2.88935591
78positive regulation of meiosis (GO:0045836)2.87888432
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87582644
80neuron cell-cell adhesion (GO:0007158)2.87157614
81very long-chain fatty acid metabolic process (GO:0000038)2.86470488
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85841024
83potassium ion import (GO:0010107)2.85708318
84water-soluble vitamin biosynthetic process (GO:0042364)2.83451753
85aspartate family amino acid catabolic process (GO:0009068)2.83023867
86acrosome assembly (GO:0001675)2.82946087
87nerve growth factor signaling pathway (GO:0038180)2.82248121
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.80632977
89mitochondrion transport along microtubule (GO:0047497)2.80632977
90dicarboxylic acid catabolic process (GO:0043649)2.80402469
91long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80324873
92fatty-acyl-CoA metabolic process (GO:0035337)2.79874619
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.78970439
94CENP-A containing nucleosome assembly (GO:0034080)2.78357416
95cellular response to epinephrine stimulus (GO:0071872)2.77406270
96response to epinephrine (GO:0071871)2.75412810
97chromatin remodeling at centromere (GO:0031055)2.74826359
98regulation of skeletal muscle contraction (GO:0014819)2.74228613
99negative regulation of inclusion body assembly (GO:0090084)2.73355185
100cholesterol biosynthetic process (GO:0006695)2.72748038
101histone exchange (GO:0043486)2.72323639
102gamma-aminobutyric acid transport (GO:0015812)2.72044597
103ribosome assembly (GO:0042255)2.71545932
104response to inactivity (GO:0014854)2.70047156
105cullin deneddylation (GO:0010388)2.69559165
106tryptophan catabolic process (GO:0006569)2.68626557
107indole-containing compound catabolic process (GO:0042436)2.68626557
108indolalkylamine catabolic process (GO:0046218)2.68626557
109magnesium ion transport (GO:0015693)2.68288316
110aspartate family amino acid biosynthetic process (GO:0009067)2.68227558
111presynaptic membrane assembly (GO:0097105)2.67462004
112serine family amino acid catabolic process (GO:0009071)2.67287698
113positive regulation of oligodendrocyte differentiation (GO:0048714)2.66286752
114negative regulation of potassium ion transmembrane transport (GO:1901380)2.66211474
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64960767
116neurotransmitter uptake (GO:0001504)2.63799657
117neuronal ion channel clustering (GO:0045161)2.63229956
118otic vesicle formation (GO:0030916)2.62650381
119positive regulation of meiotic cell cycle (GO:0051446)2.62182137
120C4-dicarboxylate transport (GO:0015740)2.59847583
121locomotory exploration behavior (GO:0035641)2.59519054
122response to muscle activity (GO:0014850)2.56506277
123response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.55441920
124cerebellar granule cell differentiation (GO:0021707)2.55403381
125protein deneddylation (GO:0000338)2.54415591
126anterior/posterior axis specification, embryo (GO:0008595)2.53179551
127cell migration involved in gastrulation (GO:0042074)2.52568895
128heart contraction (GO:0060047)2.52411283
129heart process (GO:0003015)2.52411283
130protein palmitoylation (GO:0018345)2.51151403
131cellular ketone body metabolic process (GO:0046950)2.50935869
132drug catabolic process (GO:0042737)2.50408684
133synaptic vesicle maturation (GO:0016188)2.49168527
134skeletal muscle contraction (GO:0003009)2.48999751
135tryptophan metabolic process (GO:0006568)2.48760385
136nucleobase catabolic process (GO:0046113)2.48656127
137exogenous drug catabolic process (GO:0042738)2.48589465
138aspartate family amino acid metabolic process (GO:0009066)2.47290199
139positive regulation of action potential (GO:0045760)2.46760350
140protein localization to endosome (GO:0036010)2.46600140
141positive regulation of potassium ion transport (GO:0043268)2.45700497
142sterol biosynthetic process (GO:0016126)2.45031478
143somite rostral/caudal axis specification (GO:0032525)2.44797429
144iron coordination entity transport (GO:1901678)2.44737027
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44195018
146macroautophagy (GO:0016236)2.44060147
147striated muscle contraction (GO:0006941)2.43811706
148myotube cell development (GO:0014904)2.43006623
149regulation of establishment of cell polarity (GO:2000114)2.41881816
150transmission of nerve impulse (GO:0019226)2.39993989
151synaptic transmission, cholinergic (GO:0007271)2.38627401
152regulation of membrane repolarization (GO:0060306)2.37436614
153regulation of sarcomere organization (GO:0060297)2.37285405
154organelle transport along microtubule (GO:0072384)2.37052466
155sarcoplasmic reticulum calcium ion transport (GO:0070296)2.36152736
156negative regulation of receptor-mediated endocytosis (GO:0048261)2.35526270
157male meiosis I (GO:0007141)2.35464156
158Golgi to plasma membrane protein transport (GO:0043001)2.34801803
159cardiac muscle hypertrophy (GO:0003300)2.34272437
160S-adenosylmethionine metabolic process (GO:0046500)2.33489434
161dendrite morphogenesis (GO:0048813)2.33279000
162cellular potassium ion homeostasis (GO:0030007)2.32889838
163sarcomere organization (GO:0045214)2.32295774
164protein K48-linked ubiquitination (GO:0070936)2.31292122
165amino-acid betaine metabolic process (GO:0006577)2.31142194
166sulfur amino acid biosynthetic process (GO:0000097)2.29860051
167single strand break repair (GO:0000012)2.29605572
168DNA methylation involved in gamete generation (GO:0043046)2.28347993
169establishment of protein localization to Golgi (GO:0072600)2.28314541
170membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28185087
171heme transport (GO:0015886)2.28027592
172regulation of actin filament-based movement (GO:1903115)2.27637171
173aromatic amino acid family catabolic process (GO:0009074)2.27441903
174regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.26727569
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.26420303
176cellular response to monoamine stimulus (GO:0071868)2.26186446
177cellular response to catecholamine stimulus (GO:0071870)2.26186446
178cerebral cortex radially oriented cell migration (GO:0021799)2.24924279
179negative regulation of Rho protein signal transduction (GO:0035024)2.24712398
180protein targeting to Golgi (GO:0000042)2.24029514
181positive regulation of neurological system process (GO:0031646)2.23404850
182Golgi to endosome transport (GO:0006895)2.22907050
183neuromuscular junction development (GO:0007528)2.22201627
184negative regulation of axonogenesis (GO:0050771)2.21672322
185positive regulation of potassium ion transmembrane transport (GO:1901381)2.21588315
186short-chain fatty acid metabolic process (GO:0046459)2.21186446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.10671758
2EZH2_22144423_ChIP-Seq_EOC_Human2.98386798
3GBX2_23144817_ChIP-Seq_PC3_Human2.95743945
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87659165
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.59876038
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.59541444
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36216335
8AR_21572438_ChIP-Seq_LNCaP_Human2.27233831
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24397120
10IGF1R_20145208_ChIP-Seq_DFB_Human2.14935551
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14036685
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08279908
13* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02384205
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00072283
15EZH2_27294783_Chip-Seq_NPCs_Mouse2.00058614
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.93596125
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92726412
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85523043
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.85343295
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84732340
21EWS_26573619_Chip-Seq_HEK293_Human1.84231447
22TAF15_26573619_Chip-Seq_HEK293_Human1.83762092
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82667075
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81089017
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78858067
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75686212
27DROSHA_22980978_ChIP-Seq_HELA_Human1.71113497
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69991357
29ER_23166858_ChIP-Seq_MCF-7_Human1.68987786
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68379711
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65170535
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59264664
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58912684
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56049332
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55646784
36CRX_20693478_ChIP-Seq_RETINA_Mouse1.54078794
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.52320352
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51712013
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.51667558
40STAT3_23295773_ChIP-Seq_U87_Human1.50580367
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49880562
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49728676
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49182824
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49084700
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49084700
46CBP_20019798_ChIP-Seq_JUKART_Human1.47833723
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47833723
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47301334
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46859887
50SMAD4_21799915_ChIP-Seq_A2780_Human1.46467417
51* GABP_17652178_ChIP-ChIP_JURKAT_Human1.46333037
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45276799
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45276799
54P53_22387025_ChIP-Seq_ESCs_Mouse1.44678503
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.44403322
56BCAT_22108803_ChIP-Seq_LS180_Human1.39785826
57SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.38739737
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36638297
59TP53_16413492_ChIP-PET_HCT116_Human1.36620267
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.36364276
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36197007
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35751901
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35118080
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34397578
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34384303
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32546175
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32044796
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31926290
69FUS_26573619_Chip-Seq_HEK293_Human1.31476893
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.30916794
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30131753
72P300_18555785_Chip-Seq_ESCs_Mouse1.30100666
73TCF4_23295773_ChIP-Seq_U87_Human1.29923384
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29322119
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.29306140
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28332697
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.28010614
78P300_19829295_ChIP-Seq_ESCs_Human1.27739157
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.27215864
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26090928
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25651639
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25549138
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.25143904
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25044783
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24109544
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.23946989
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23386065
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21522674
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21006413
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20929070
91REST_21632747_ChIP-Seq_MESCs_Mouse1.20350043
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.19008796
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18253654
94ELK1_19687146_ChIP-ChIP_HELA_Human1.18065917
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.17722486
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17617892
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17070325
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.16936273
99CDX2_22108803_ChIP-Seq_LS180_Human1.16793076
100NANOG_19829295_ChIP-Seq_ESCs_Human1.16732221
101SOX2_19829295_ChIP-Seq_ESCs_Human1.16732221
102* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15696309
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15251408
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14748629
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12811139
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12759872
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11909025
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.10719748
109RUNX2_22187159_ChIP-Seq_PCA_Human1.09267750
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.08452842
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.07855397
112TCF4_22108803_ChIP-Seq_LS180_Human1.07823507
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07761747
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.07583461
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05940918
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05257500
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05031770
118TBL1_22424771_ChIP-Seq_293T_Human1.04662060
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.04647018
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04451285
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04111139
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03944744
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02999667
124PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02773108
125AHR_22903824_ChIP-Seq_MCF-7_Human1.02495852
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01629666
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00918651
128ZNF274_21170338_ChIP-Seq_K562_Hela1.00238992
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99747317
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99437858
131PU1_27457419_Chip-Seq_LIVER_Mouse0.99373278
132HTT_18923047_ChIP-ChIP_STHdh_Human0.99348752
133RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99187656
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99157763
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.98241588
136LXR_22158963_ChIP-Seq_LIVER_Mouse0.98017876
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.97823536
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.97014804
139CBP_21632823_ChIP-Seq_H3396_Human0.96782575
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.96653446
141AR_19668381_ChIP-Seq_PC3_Human0.96450451
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95725088
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.95471539
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.94824964
145SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94601078
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93997148
147AR_25329375_ChIP-Seq_VCAP_Human0.93943615
148EOMES_21245162_ChIP-Seq_HESCs_Human0.93575338
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93243277
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.93240097
151* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93151507
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92913948
153ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92846424
154VDR_22108803_ChIP-Seq_LS180_Human0.92539016
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.91959096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.15138369
2MP0003950_abnormal_plasma_membrane3.45365841
3MP0008877_abnormal_DNA_methylation3.21780923
4MP0003880_abnormal_central_pattern3.14879158
5MP0004270_analgesia2.94367823
6MP0003690_abnormal_glial_cell2.89656127
7MP0003011_delayed_dark_adaptation2.85424012
8MP0003329_amyloid_beta_deposits2.74420972
9MP0004859_abnormal_synaptic_plasticity2.62834893
10MP0002837_dystrophic_cardiac_calcinosis2.54315423
11MP0004885_abnormal_endolymph2.41965285
12MP0001188_hyperpigmentation2.33588125
13MP0003890_abnormal_embryonic-extraembry2.31103359
14MP0002272_abnormal_nervous_system2.27768623
15MP0004043_abnormal_pH_regulation2.26515779
16MP0004145_abnormal_muscle_electrophysio2.21072129
17MP0001486_abnormal_startle_reflex2.17751347
18MP0004036_abnormal_muscle_relaxation2.03690780
19MP0002064_seizures2.03264964
20MP0000751_myopathy2.01266600
21MP0001485_abnormal_pinna_reflex1.96927904
22MP0003634_abnormal_glial_cell1.92873913
23MP0003635_abnormal_synaptic_transmissio1.92451615
24MP0003718_maternal_effect1.91142856
25MP0001529_abnormal_vocalization1.83591738
26MP0000747_muscle_weakness1.81487604
27MP0009697_abnormal_copulation1.80001536
28MP0004742_abnormal_vestibular_system1.79715716
29MP0009046_muscle_twitch1.76550175
30MP0002229_neurodegeneration1.76157007
31MP0004142_abnormal_muscle_tone1.71589182
32MP0004215_abnormal_myocardial_fiber1.71547134
33MP0000749_muscle_degeneration1.69847194
34MP0001984_abnormal_olfaction1.69156981
35MP0002822_catalepsy1.68262711
36MP0002102_abnormal_ear_morphology1.68168753
37MP0003806_abnormal_nucleotide_metabolis1.68127467
38MP0003941_abnormal_skin_development1.67823147
39MP0002638_abnormal_pupillary_reflex1.67655824
40MP0003632_abnormal_nervous_system1.66472019
41MP0006036_abnormal_mitochondrial_physio1.65930978
42MP0005410_abnormal_fertilization1.61693214
43MP0000778_abnormal_nervous_system1.61524874
44MP0003868_abnormal_feces_composition1.60566726
45MP0009745_abnormal_behavioral_response1.60394596
46MP0003186_abnormal_redox_activity1.52444566
47MP0001299_abnormal_eye_distance/1.52067168
48MP0002734_abnormal_mechanical_nocicepti1.51695264
49MP0004185_abnormal_adipocyte_glucose1.50972319
50MP0006035_abnormal_mitochondrial_morpho1.50007197
51MP0001905_abnormal_dopamine_level1.49689791
52MP0002139_abnormal_hepatobiliary_system1.48902003
53MP0004084_abnormal_cardiac_muscle1.48320516
54MP0003195_calcinosis1.47763946
55MP0005171_absent_coat_pigmentation1.42726078
56MP0003631_nervous_system_phenotype1.40941949
57MP0003137_abnormal_impulse_conducting1.40073889
58MP0002138_abnormal_hepatobiliary_system1.39456931
59MP0008569_lethality_at_weaning1.37988749
60MP0005423_abnormal_somatic_nervous1.36710410
61MP0002332_abnormal_exercise_endurance1.36076062
62MP0003633_abnormal_nervous_system1.35934164
63MP0000955_abnormal_spinal_cord1.34857781
64MP0002063_abnormal_learning/memory/cond1.34381010
65MP0005330_cardiomyopathy1.34121781
66MP0003646_muscle_fatigue1.33945156
67MP0004130_abnormal_muscle_cell1.31631320
68MP0000604_amyloidosis1.31340956
69MP0005551_abnormal_eye_electrophysiolog1.31323386
70MP0000750_abnormal_muscle_regeneration1.29902315
71MP0003221_abnormal_cardiomyocyte_apopto1.28583580
72MP0002736_abnormal_nociception_after1.27433973
73MP0005409_darkened_coat_color1.26981346
74MP0002067_abnormal_sensory_capabilities1.25331936
75MP0004924_abnormal_behavior1.25083042
76MP0005386_behavior/neurological_phenoty1.25083042
77MP0002572_abnormal_emotion/affect_behav1.24658992
78MP0006276_abnormal_autonomic_nervous1.23491530
79MP0003656_abnormal_erythrocyte_physiolo1.22562144
80MP0001440_abnormal_grooming_behavior1.22525608
81MP0005451_abnormal_body_composition1.22223319
82MP0005620_abnormal_muscle_contractility1.21812310
83MP0000462_abnormal_digestive_system1.19485903
84MP0006072_abnormal_retinal_apoptosis1.19211549
85MP0002882_abnormal_neuron_morphology1.17670690
86MP0002066_abnormal_motor_capabilities/c1.16943098
87MP0000569_abnormal_digit_pigmentation1.15605747
88MP0004147_increased_porphyrin_level1.15264715
89MP0010678_abnormal_skin_adnexa1.14427575
90MP0004087_abnormal_muscle_fiber1.14241775
91MP0001661_extended_life_span1.12774085
92MP0001666_abnormal_nutrient_absorption1.10920624
93MP0004085_abnormal_heartbeat1.09956646
94MP0005253_abnormal_eye_physiology1.08850513
95MP0008775_abnormal_heart_ventricle1.07390049
96MP0008058_abnormal_DNA_repair1.07355694
97MP0005266_abnormal_metabolism1.06696937
98MP0005187_abnormal_penis_morphology1.05060796
99MP0009780_abnormal_chondrocyte_physiolo1.04934659
100MP0001764_abnormal_homeostasis1.04250593
101MP0004134_abnormal_chest_morphology1.03720769
102MP0002269_muscular_atrophy1.03635564
103MP0002972_abnormal_cardiac_muscle1.03225201
104MP0005666_abnormal_adipose_tissue1.02006501
105MP0002735_abnormal_chemical_nociception1.00061179
106MP0005646_abnormal_pituitary_gland0.99347966
107MP0001177_atelectasis0.96288851
108MP0008875_abnormal_xenobiotic_pharmacok0.93889962
109MP0003567_abnormal_fetal_cardiomyocyte0.93644167
110MP0005385_cardiovascular_system_phenoty0.92632123
111MP0001544_abnormal_cardiovascular_syste0.92632123
112MP0003136_yellow_coat_color0.92328484
113MP0005365_abnormal_bile_salt0.91930553
114MP0002277_abnormal_respiratory_mucosa0.91749985
115MP0001501_abnormal_sleep_pattern0.91624014
116MP0004484_altered_response_of0.91495555
117MP0005332_abnormal_amino_acid0.91153387
118MP0000003_abnormal_adipose_tissue0.89517749
119MP0001970_abnormal_pain_threshold0.88972059
120MP0002106_abnormal_muscle_physiology0.88170849
121MP0005375_adipose_tissue_phenotype0.87987306
122MP0001963_abnormal_hearing_physiology0.86655661
123MP0006138_congestive_heart_failure0.86309809
124MP0002118_abnormal_lipid_homeostasis0.86299417
125MP0002210_abnormal_sex_determination0.85894327
126MP0002752_abnormal_somatic_nervous0.85639601
127MP0001968_abnormal_touch/_nociception0.85159030
128MP0002254_reproductive_system_inflammat0.84931800
129MP0005360_urolithiasis0.82913594
130MP0005085_abnormal_gallbladder_physiolo0.82149539
131MP0000013_abnormal_adipose_tissue0.82136178
132MP0000759_abnormal_skeletal_muscle0.81698949
133MP0005369_muscle_phenotype0.81575779
134MP0004233_abnormal_muscle_weight0.81344090
135MP0002090_abnormal_vision0.80329298
136MP0001986_abnormal_taste_sensitivity0.80188020
137MP0008260_abnormal_autophagy0.79939180
138MP0008789_abnormal_olfactory_epithelium0.79359020
139MP0002152_abnormal_brain_morphology0.77998178
140MP0003252_abnormal_bile_duct0.77141675
141MP0001502_abnormal_circadian_rhythm0.75765537
142MP0000579_abnormal_nail_morphology0.73409644
143MP0005623_abnormal_meninges_morphology0.72367835
144MP0002733_abnormal_thermal_nociception0.72123475

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.05891165
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.05891165
3Nemaline bodies (HP:0003798)5.26074753
4Muscle fiber inclusion bodies (HP:0100299)5.22132044
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.09355899
6Neurofibrillary tangles (HP:0002185)4.96793310
7Abnormality of the corticospinal tract (HP:0002492)4.80892803
8Insidious onset (HP:0003587)4.08471791
9Termporal pattern (HP:0011008)4.08471791
10Peripheral hypomyelination (HP:0007182)3.88306773
11Spastic gait (HP:0002064)3.87992967
12Cerebral inclusion bodies (HP:0100314)3.75090907
13Rimmed vacuoles (HP:0003805)3.55318699
14Genetic anticipation (HP:0003743)3.44399018
15Onion bulb formation (HP:0003383)3.38480304
16Intention tremor (HP:0002080)3.33766535
17Scanning speech (HP:0002168)3.28416353
18Dysmetria (HP:0001310)3.23110900
19Supranuclear gaze palsy (HP:0000605)3.21389358
20Ankle clonus (HP:0011448)3.17114042
21Abnormal auditory evoked potentials (HP:0006958)3.13801931
22Shoulder girdle muscle weakness (HP:0003547)3.10788970
23Cerebral hypomyelination (HP:0006808)3.10688500
24Pheochromocytoma (HP:0002666)3.09125777
25Muscle fiber splitting (HP:0003555)3.06278245
26Hyporeflexia of lower limbs (HP:0002600)3.05618056
27Myokymia (HP:0002411)3.05042339
28Type 1 muscle fiber predominance (HP:0003803)2.98239315
29Muscle hypertrophy of the lower extremities (HP:0008968)2.87119097
30Exercise-induced myalgia (HP:0003738)2.85918702
31Progressive cerebellar ataxia (HP:0002073)2.83321148
32Lower limb muscle weakness (HP:0007340)2.82854337
33Distal arthrogryposis (HP:0005684)2.82612032
34Leukodystrophy (HP:0002415)2.76511309
35Focal motor seizures (HP:0011153)2.74565166
36Sensory axonal neuropathy (HP:0003390)2.70800333
37Urinary urgency (HP:0000012)2.70709158
38Abnormality of the musculature of the pelvis (HP:0001469)2.63468392
39Abnormality of the hip-girdle musculature (HP:0001445)2.63468392
40Neuroendocrine neoplasm (HP:0100634)2.60704535
41Abnormality of alanine metabolism (HP:0010916)2.58735588
42Hyperalaninemia (HP:0003348)2.58735588
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58735588
44Atonic seizures (HP:0010819)2.57461916
45Absence seizures (HP:0002121)2.56429555
46Difficulty running (HP:0009046)2.55012681
47Alacrima (HP:0000522)2.51877588
48Action tremor (HP:0002345)2.50060094
49CNS hypomyelination (HP:0003429)2.48814875
50Slow saccadic eye movements (HP:0000514)2.48123687
51Gowers sign (HP:0003391)2.47832253
52Impaired vibratory sensation (HP:0002495)2.47221504
53Abnormality of the left ventricular outflow tract (HP:0011103)2.46433196
54Subaortic stenosis (HP:0001682)2.46433196
55Foot dorsiflexor weakness (HP:0009027)2.45991074
56Calf muscle hypertrophy (HP:0008981)2.45586011
57Hyperglycinuria (HP:0003108)2.45203694
58Areflexia of lower limbs (HP:0002522)2.40800577
59Dialeptic seizures (HP:0011146)2.40258370
60Abnormality of glycolysis (HP:0004366)2.38231719
61Increased serum pyruvate (HP:0003542)2.38231719
62Poor speech (HP:0002465)2.37899442
63Spastic tetraparesis (HP:0001285)2.36975816
64Increased circulating renin level (HP:0000848)2.36752249
65Retinal dysplasia (HP:0007973)2.36648716
66Hyperglycinemia (HP:0002154)2.35735735
67Exercise-induced muscle cramps (HP:0003710)2.35462910
68Urinary bladder sphincter dysfunction (HP:0002839)2.34935735
69Dysmetric saccades (HP:0000641)2.34461351
70Intrahepatic cholestasis (HP:0001406)2.33845372
71Clonus (HP:0002169)2.33420469
72Pelvic girdle muscle weakness (HP:0003749)2.33369318
73Fair hair (HP:0002286)2.31450112
74Abnormality of the foot musculature (HP:0001436)2.30610642
75Abnormality of serum amino acid levels (HP:0003112)2.29692390
76Abnormality of serine family amino acid metabolism (HP:0010894)2.28536085
77Abnormality of glycine metabolism (HP:0010895)2.28536085
78Cerebral hemorrhage (HP:0001342)2.26106246
79Abnormality of the labia minora (HP:0012880)2.25891142
80Choreoathetosis (HP:0001266)2.25451158
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25249272
82Inability to walk (HP:0002540)2.24812740
83Dysdiadochokinesis (HP:0002075)2.24618612
84Aplasia involving bones of the upper limbs (HP:0009823)2.23069128
85Aplasia of the phalanges of the hand (HP:0009802)2.23069128
86Aplasia involving bones of the extremities (HP:0009825)2.23069128
87Anteriorly placed anus (HP:0001545)2.22539665
88Spastic paraparesis (HP:0002313)2.18407807
89Impaired vibration sensation in the lower limbs (HP:0002166)2.16896046
90Febrile seizures (HP:0002373)2.16794284
91Prolonged partial thromboplastin time (HP:0003645)2.16502235
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14434803
93Megalencephaly (HP:0001355)2.13719164
94Morphological abnormality of the inner ear (HP:0011390)2.13029546
95Progressive inability to walk (HP:0002505)2.12707037
96Bundle branch block (HP:0011710)2.11461027
97Sudden death (HP:0001699)2.10578086
98Clumsiness (HP:0002312)2.10130669
99Morphological abnormality of the pyramidal tract (HP:0002062)2.07010200
100Acute encephalopathy (HP:0006846)2.06935744
101Postural instability (HP:0002172)2.06751815
102Papillary thyroid carcinoma (HP:0002895)2.06722859
103Thickened helices (HP:0000391)2.06324065
104Hammertoe (HP:0001765)2.05009361
105Spastic paraplegia (HP:0001258)2.02499598
106Metabolic alkalosis (HP:0200114)1.96356350
107Confusion (HP:0001289)1.95393765
108Generalized aminoaciduria (HP:0002909)1.94900114
109Hypokalemic alkalosis (HP:0001949)1.94877582
110Hypobetalipoproteinemia (HP:0003563)1.94659703
111Decreased motor nerve conduction velocity (HP:0003431)1.94456397
112EMG: myopathic abnormalities (HP:0003458)1.91906971
113Lipid accumulation in hepatocytes (HP:0006561)1.91646616
114Focal seizures (HP:0007359)1.91304846
115Hyperlipoproteinemia (HP:0010980)1.90336669
116Decreased lacrimation (HP:0000633)1.89439004
117Autoamputation (HP:0001218)1.87608995
118Long clavicles (HP:0000890)1.87181876
119Scapular winging (HP:0003691)1.87116900
120Increased hepatocellular lipid droplets (HP:0006565)1.86991352
121Rhabdomyolysis (HP:0003201)1.86031684
122Methylmalonic acidemia (HP:0002912)1.85379319
123Hyperventilation (HP:0002883)1.83887642
124Acute necrotizing encephalopathy (HP:0006965)1.83561587
125Paraparesis (HP:0002385)1.83496005
126Premature skin wrinkling (HP:0100678)1.81598562
127Facial diplegia (HP:0001349)1.81083398
128Bowel incontinence (HP:0002607)1.80256923
129Split foot (HP:0001839)1.79825332
130Stridor (HP:0010307)1.79332599
131Increased CSF lactate (HP:0002490)1.79152606
132Myoglobinuria (HP:0002913)1.79079688
133Abnormality of the calf musculature (HP:0001430)1.78765895
134Broad-based gait (HP:0002136)1.78693731
135Paraplegia (HP:0010550)1.77258797
136Chorioretinal atrophy (HP:0000533)1.77212954
137Prolonged QT interval (HP:0001657)1.76929918
138Abnormality of saccadic eye movements (HP:0000570)1.76710586
139Atrial fibrillation (HP:0005110)1.76471808
140Decreased muscle mass (HP:0003199)1.76103339
141Gaze-evoked nystagmus (HP:0000640)1.75092880
142Postnatal microcephaly (HP:0005484)1.73812233
143Inappropriate behavior (HP:0000719)1.73672203
144Generalized myoclonic seizures (HP:0002123)1.73487536
145Epileptic encephalopathy (HP:0200134)1.72700374
146Mitochondrial inheritance (HP:0001427)1.72523987
147Ketosis (HP:0001946)1.72009419
148Segmental peripheral demyelination/remyelination (HP:0003481)1.70714614
149Urinary incontinence (HP:0000020)1.70217369
150Distal sensory impairment (HP:0002936)1.70181347
151Absent phalangeal crease (HP:0006109)1.70116545
152Pendular nystagmus (HP:0012043)1.69820513
153Palpitations (HP:0001962)1.69077755
154Abnormality of the salivary glands (HP:0010286)1.68883585
155Drooling (HP:0002307)1.68855947
156Methylmalonic aciduria (HP:0012120)1.68798095
157Hypoglycemic coma (HP:0001325)1.68710673
158Poor eye contact (HP:0000817)1.68153768
159Synostosis involving the elbow (HP:0003938)1.67993932
160Humeroradial synostosis (HP:0003041)1.67993932
161Hepatic necrosis (HP:0002605)1.67807569
162Gonadotropin excess (HP:0000837)1.67316814
163Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.66996048
164Abnormality of the renal cortex (HP:0011035)1.65306005
165Hypochromic microcytic anemia (HP:0004840)1.65171193
166Abnormality of the shoulder girdle musculature (HP:0001435)1.64696259
167Progressive macrocephaly (HP:0004481)1.63817339
168Renal cortical cysts (HP:0000803)1.63245643
169Poor suck (HP:0002033)1.63210966
170Abnormality of the vitamin B12 metabolism (HP:0004341)1.63006848
171Fetal akinesia sequence (HP:0001989)1.62481933
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62185526
173Heart block (HP:0012722)1.60731455
174Abnormality of methionine metabolism (HP:0010901)1.60138464
175Hepatocellular necrosis (HP:0001404)1.58633727
176Cerebral edema (HP:0002181)1.58048392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.13659613
2OXSR13.70398285
3ACVR1B3.28683823
4FRK2.96137699
5TRIM282.74570578
6PKN12.59764790
7WNK42.50591860
8EPHB12.42729483
9WNK12.31464032
10MKNK22.25873767
11FGFR22.23135292
12AKT32.17749328
13BMPR1B2.15840864
14EIF2AK32.14219473
15TSSK62.09603875
16MAPKAPK52.06842097
17STK242.03265632
18STK161.95359315
19PHKG21.93458403
20PHKG11.93458403
21MUSK1.89168641
22EPHA41.85287983
23BCR1.83421462
24MET1.79375703
25TYRO31.77948666
26LIMK11.77896306
27PINK11.65277544
28ERBB31.65112987
29SGK4941.64142577
30SGK2231.64142577
31PAK61.60775591
32NTRK11.56960822
33PAK31.55694845
34MKNK11.55563946
35CDK191.50274794
36NEK61.46286974
37MAP3K41.42533076
38CAMK2B1.40322068
39CAMK2D1.37486809
40OBSCN1.37352949
41ROCK21.33011260
42ZAK1.30217155
43CSNK1A1L1.29366405
44MST41.27268122
45ERBB41.27232974
46PRKD31.25323101
47INSRR1.24443404
48TNIK1.23879436
49UHMK11.23694060
50PDK31.23376721
51PDK41.23376721
52LATS21.22692881
53KSR21.22453250
54CSNK1G21.21812811
55PNCK1.21458906
56MARK11.19089999
57CSNK1G31.16570271
58STK38L1.15131327
59CAMK2G1.14965599
60PDK21.13090658
61NTRK31.12983656
62MARK21.10773317
63LMTK21.08672341
64PRKD11.07451053
65STK31.06517115
66PLK31.06292543
67DMPK1.04494094
68EIF2AK11.03692776
69SRPK11.02175453
70MAP3K131.01001984
71MAP4K21.00846275
72NUAK10.98211115
73BRAF0.97996382
74PRKCG0.97463015
75ICK0.97212838
76PIK3CA0.97084296
77CAMK2A0.95691651
78PBK0.93496560
79MAPK130.92131356
80CSNK1G10.91800453
81TTN0.90072269
82PIK3CG0.89884882
83PLK20.88548116
84GRK10.88421150
85NTRK20.86120434
86TTK0.84377411
87MAP3K20.83014292
88CDK50.82866008
89DYRK30.81480865
90PRKCQ0.80712444
91PDPK10.78729240
92TGFBR10.78046981
93TAF10.72888236
94FGR0.71592170
95PLK40.71261833
96MAP3K90.70629468
97CAMK1G0.68640337
98RET0.67523315
99ADRBK20.67299691
100PDGFRB0.67292615
101PRPF4B0.65635267
102LATS10.65431875
103SGK20.64941684
104PRKCH0.64368869
105EIF2AK20.64015087
106DYRK20.62979327
107BCKDK0.62809867
108CSNK1D0.61155805
109BUB10.61131870
110TRPM70.60826512
111PDK10.59790096
112NEK10.59736091
113PRKACB0.58222893
114MAP2K40.57903716
115CCNB10.57052537
116PRKCE0.56251950
117FES0.55454535
118ROCK10.54650843
119BRSK20.53255889
120PLK10.51715964
121SIK30.51055683
122CASK0.50794072
123MAP3K70.49951022
124PRKAA20.49502379
125CDK140.49441167
126MAP2K70.48282217
127PRKG10.46337164
128STK110.46252840
129SGK10.46196476
130CDK150.45694638
131NEK90.45313513
132MINK10.44645626
133MAPKAPK30.43964720
134TESK20.42905767
135NME10.42714978
136MAPK100.42657494
137PRKAA10.42584711
138MAP3K50.42244364
139DYRK1A0.41538646
140IRAK20.41518742
141MAPK120.41001491
142FYN0.40142074
143PRKACA0.39817810
144CSNK1E0.39091631
145CDK180.38645867
146WNK30.38534185
147RPS6KA30.38083768
148GSK3A0.37383864
149SGK30.36679620
150KSR10.36155531
151GRK70.34522141
152VRK10.33309022

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.20341007
2Fatty acid elongation_Homo sapiens_hsa000623.16617646
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.84471794
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63984109
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60353996
6Caffeine metabolism_Homo sapiens_hsa002322.50567719
7Propanoate metabolism_Homo sapiens_hsa006402.21627692
8Butanoate metabolism_Homo sapiens_hsa006502.16139628
9Circadian rhythm_Homo sapiens_hsa047102.10495858
10Steroid biosynthesis_Homo sapiens_hsa001002.10374612
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04866000
12Vitamin B6 metabolism_Homo sapiens_hsa007502.03137768
13Ether lipid metabolism_Homo sapiens_hsa005651.95958424
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91994149
15Sulfur metabolism_Homo sapiens_hsa009201.89277333
16Retinol metabolism_Homo sapiens_hsa008301.82369291
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81163521
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72193650
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70502408
20Fatty acid metabolism_Homo sapiens_hsa012121.68425528
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53200845
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52103725
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49274356
24Basal transcription factors_Homo sapiens_hsa030221.44461123
25GABAergic synapse_Homo sapiens_hsa047271.43838575
26Fatty acid degradation_Homo sapiens_hsa000711.38453788
27Glutamatergic synapse_Homo sapiens_hsa047241.34422917
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34211128
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.33762389
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32177302
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29823641
32RNA polymerase_Homo sapiens_hsa030201.25303176
33Pyruvate metabolism_Homo sapiens_hsa006201.23352028
34Arginine and proline metabolism_Homo sapiens_hsa003301.23169050
35Arginine biosynthesis_Homo sapiens_hsa002201.22243030
36Chemical carcinogenesis_Homo sapiens_hsa052041.20381700
37Cardiac muscle contraction_Homo sapiens_hsa042601.19845054
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15211023
39Fatty acid biosynthesis_Homo sapiens_hsa000611.15164364
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14685371
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14420137
42Histidine metabolism_Homo sapiens_hsa003401.09476664
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07565710
44RNA degradation_Homo sapiens_hsa030181.05368257
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02458158
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01627321
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00336004
48Circadian entrainment_Homo sapiens_hsa047130.99651744
49Peroxisome_Homo sapiens_hsa041460.96401957
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95339629
51Linoleic acid metabolism_Homo sapiens_hsa005910.95131266
52Gastric acid secretion_Homo sapiens_hsa049710.94889278
53Axon guidance_Homo sapiens_hsa043600.94493916
54Dorso-ventral axis formation_Homo sapiens_hsa043200.93592120
55Morphine addiction_Homo sapiens_hsa050320.93507427
56Selenocompound metabolism_Homo sapiens_hsa004500.92252071
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92084939
58Long-term depression_Homo sapiens_hsa047300.90793315
59Regulation of autophagy_Homo sapiens_hsa041400.90459882
60Salivary secretion_Homo sapiens_hsa049700.90365854
61Renal cell carcinoma_Homo sapiens_hsa052110.88454573
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88328540
63Dilated cardiomyopathy_Homo sapiens_hsa054140.88278684
64Sphingolipid metabolism_Homo sapiens_hsa006000.88115879
65Oxidative phosphorylation_Homo sapiens_hsa001900.87358063
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.84716343
67Nicotine addiction_Homo sapiens_hsa050330.84203411
68Sulfur relay system_Homo sapiens_hsa041220.83468670
69Complement and coagulation cascades_Homo sapiens_hsa046100.83077146
70Bile secretion_Homo sapiens_hsa049760.82233694
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81410241
72Serotonergic synapse_Homo sapiens_hsa047260.80519830
73PPAR signaling pathway_Homo sapiens_hsa033200.78718570
74Insulin secretion_Homo sapiens_hsa049110.78146448
75Oocyte meiosis_Homo sapiens_hsa041140.77528413
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.76871422
77Cocaine addiction_Homo sapiens_hsa050300.76860945
78Phototransduction_Homo sapiens_hsa047440.76371663
79Cholinergic synapse_Homo sapiens_hsa047250.76252582
80beta-Alanine metabolism_Homo sapiens_hsa004100.76078685
81Proteasome_Homo sapiens_hsa030500.74443362
82Dopaminergic synapse_Homo sapiens_hsa047280.74187951
83Olfactory transduction_Homo sapiens_hsa047400.71223672
84Ovarian steroidogenesis_Homo sapiens_hsa049130.70692919
85Tryptophan metabolism_Homo sapiens_hsa003800.70673170
86RNA transport_Homo sapiens_hsa030130.70500770
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70399335
88Long-term potentiation_Homo sapiens_hsa047200.69963331
89Synaptic vesicle cycle_Homo sapiens_hsa047210.69553725
90Amphetamine addiction_Homo sapiens_hsa050310.69268827
91Phenylalanine metabolism_Homo sapiens_hsa003600.68020914
92Carbon metabolism_Homo sapiens_hsa012000.68019673
93Mineral absorption_Homo sapiens_hsa049780.66573302
94Alzheimers disease_Homo sapiens_hsa050100.66506418
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66465996
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66435250
97Tight junction_Homo sapiens_hsa045300.66175747
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.65749377
99ABC transporters_Homo sapiens_hsa020100.65523120
100Parkinsons disease_Homo sapiens_hsa050120.65061775
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64151970
102One carbon pool by folate_Homo sapiens_hsa006700.63629511
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62967067
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62908715
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.62834354
106Starch and sucrose metabolism_Homo sapiens_hsa005000.61651134
107cAMP signaling pathway_Homo sapiens_hsa040240.59733361
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59666993
109Renin secretion_Homo sapiens_hsa049240.59104976
110Biosynthesis of amino acids_Homo sapiens_hsa012300.58697191
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55755345
112Metabolic pathways_Homo sapiens_hsa011000.55754019
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.55681409
114Taste transduction_Homo sapiens_hsa047420.55544562
115Oxytocin signaling pathway_Homo sapiens_hsa049210.54713893
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54084747
117mRNA surveillance pathway_Homo sapiens_hsa030150.53029816
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52622709
119Pancreatic secretion_Homo sapiens_hsa049720.51927882
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51724205
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50893923
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.50579874
123Protein export_Homo sapiens_hsa030600.50489982
124Type II diabetes mellitus_Homo sapiens_hsa049300.50307509
125Choline metabolism in cancer_Homo sapiens_hsa052310.49573593
126ErbB signaling pathway_Homo sapiens_hsa040120.47978045
127Gap junction_Homo sapiens_hsa045400.47142376
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46543085
129Glycerolipid metabolism_Homo sapiens_hsa005610.45696825
130Collecting duct acid secretion_Homo sapiens_hsa049660.45473785
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.43482388
132Endocytosis_Homo sapiens_hsa041440.43404757
133Thyroid hormone synthesis_Homo sapiens_hsa049180.41923609
134Calcium signaling pathway_Homo sapiens_hsa040200.41756217
135Huntingtons disease_Homo sapiens_hsa050160.41713219
136Folate biosynthesis_Homo sapiens_hsa007900.41698934
137GnRH signaling pathway_Homo sapiens_hsa049120.40519099
138Purine metabolism_Homo sapiens_hsa002300.39799606

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