CDC37P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)5.56691065
2nephron epithelium morphogenesis (GO:0072088)5.33059727
3nephron tubule morphogenesis (GO:0072078)5.33059727
4regulation of integrin activation (GO:0033623)5.27289740
5negative regulation of inclusion body assembly (GO:0090084)5.24877530
6negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.18940810
7positive regulation of actin filament depolymerization (GO:0030836)5.04283366
8astrocyte differentiation (GO:0048708)5.03858675
9regulation of hydrogen peroxide metabolic process (GO:0010310)5.02772217
10neuron remodeling (GO:0016322)4.90028333
11pattern specification involved in kidney development (GO:0061004)4.58869344
12protein refolding (GO:0042026)4.50471959
13response to peptidoglycan (GO:0032494)4.44378329
14ubiquinone biosynthetic process (GO:0006744)4.43595353
15adenine nucleotide transport (GO:0051503)4.34259641
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26522066
17chaperone mediated protein folding requiring cofactor (GO:0051085)4.26247470
18neuron fate determination (GO:0048664)4.23027383
19purine-containing compound salvage (GO:0043101)4.15798757
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.10260811
21regulation of mesenchymal cell apoptotic process (GO:2001053)4.08319190
22purine ribonucleotide transport (GO:0015868)4.07824711
23negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.03139536
24radial glial cell differentiation (GO:0060019)3.92565866
25ubiquinone metabolic process (GO:0006743)3.91811661
26response to muramyl dipeptide (GO:0032495)3.89579794
27nephron tubule formation (GO:0072079)3.85582129
28response to gravity (GO:0009629)3.77274870
29UV protection (GO:0009650)3.76797592
30macroautophagy (GO:0016236)3.70586754
31ATP synthesis coupled proton transport (GO:0015986)3.67007968
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67007968
33protein insertion into membrane (GO:0051205)3.65242244
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.60734245
35negative regulation of alcohol biosynthetic process (GO:1902931)3.60563946
36amyloid precursor protein catabolic process (GO:0042987)3.60202438
37regulation of inositol phosphate biosynthetic process (GO:0010919)3.59176161
38nucleoside transport (GO:0015858)3.45563573
39quinone biosynthetic process (GO:1901663)3.44891103
40gap junction assembly (GO:0016264)3.38569367
41platelet aggregation (GO:0070527)3.36266131
42regulation of inclusion body assembly (GO:0090083)3.36111743
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35119265
44neuronal stem cell maintenance (GO:0097150)3.34474866
45positive regulation of protein depolymerization (GO:1901881)3.31909336
46mature B cell differentiation involved in immune response (GO:0002313)3.25752978
47oligodendrocyte development (GO:0014003)3.24692102
48NAD biosynthetic process (GO:0009435)3.22255750
49protein maturation by protein folding (GO:0022417)3.21324721
50proteasome assembly (GO:0043248)3.20003529
51GDP-mannose metabolic process (GO:0019673)3.19437578
52regulation of monocyte differentiation (GO:0045655)3.17991670
53positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.14912212
54purine nucleotide transport (GO:0015865)3.14306420
55positive regulation of extracellular matrix organization (GO:1903055)3.12354449
56renal tubule morphogenesis (GO:0061333)3.07383940
57positive regulation of male gonad development (GO:2000020)3.04818818
58positive regulation of receptor biosynthetic process (GO:0010870)2.98610416
59response to interferon-beta (GO:0035456)2.96642020
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93320823
61positive regulation of triglyceride biosynthetic process (GO:0010867)2.92908095
62regulation of histone phosphorylation (GO:0033127)2.92864353
63galactose catabolic process (GO:0019388)2.90864816
64protein kinase C signaling (GO:0070528)2.90367725
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.88790884
66regulation of glycogen (starch) synthase activity (GO:2000465)2.88309046
67regulation of metalloenzyme activity (GO:0048552)2.86590190
68telencephalon development (GO:0021537)2.84094592
69mitochondrion morphogenesis (GO:0070584)2.81196208
70regulation of mast cell degranulation (GO:0043304)2.78749987
71positive regulation of vasculogenesis (GO:2001214)2.75580654
72negative regulation of B cell apoptotic process (GO:0002903)2.73343385
73positive regulation of macrophage differentiation (GO:0045651)2.72826755
74cellular response to interferon-beta (GO:0035458)2.71436137
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71394065
76GMP metabolic process (GO:0046037)2.71170000
77pinocytosis (GO:0006907)2.70953062
78UTP biosynthetic process (GO:0006228)2.70664318
79pentose metabolic process (GO:0019321)2.69622096
80positive regulation of protein complex disassembly (GO:0043243)2.65329405
81heart valve formation (GO:0003188)2.65157965
82negative regulation by host of viral transcription (GO:0043922)2.64661784
83rRNA catabolic process (GO:0016075)2.63384154
84purine nucleobase metabolic process (GO:0006144)2.62866147
85positive regulation of mast cell degranulation (GO:0043306)2.62649690
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.62649690
87Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62643690
88regulation of mast cell activation involved in immune response (GO:0033006)2.62093543
89auditory receptor cell differentiation (GO:0042491)2.59603994
90autophagic vacuole fusion (GO:0000046)2.58273090
91electron transport chain (GO:0022900)2.57882240
92homotypic cell-cell adhesion (GO:0034109)2.57377974
93respiratory electron transport chain (GO:0022904)2.56192157
94estrogen biosynthetic process (GO:0006703)2.55902508
95mature B cell differentiation (GO:0002335)2.54650533
96response to misfolded protein (GO:0051788)2.50739972
97relaxation of smooth muscle (GO:0044557)2.50713129
98negative regulation of viral transcription (GO:0032897)2.50141382
99cellular metabolic compound salvage (GO:0043094)2.48065652
100positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.45912262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.50816472
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64152400
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.94421997
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52174315
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38318416
6GATA1_22025678_ChIP-Seq_K562_Human2.25880626
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17105610
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11485730
9SCL_19346495_ChIP-Seq_HPC-7_Human2.05160783
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96993455
11LXR_22292898_ChIP-Seq_THP-1_Human1.90234272
12CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88423605
13MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87163986
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86756764
15SRF_21415370_ChIP-Seq_HL-1_Mouse1.86373454
16GATA1_19941826_ChIP-Seq_K562_Human1.84936223
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.79363174
18ZNF263_19887448_ChIP-Seq_K562_Human1.78934046
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78874674
20P68_20966046_ChIP-Seq_HELA_Human1.76640741
21HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.76131675
22E2F1_20622854_ChIP-Seq_HELA_Human1.70576192
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.70516591
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70238007
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70172138
26GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.68208650
27BCL6_27268052_Chip-Seq_Bcells_Human1.67883800
28VDR_21846776_ChIP-Seq_THP-1_Human1.65521716
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59548496
30TP53_22127205_ChIP-Seq_IMR90_Human1.59270697
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57760333
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57304673
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.54781671
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53682285
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53489902
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.52935113
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52322111
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51855585
39CTCF_26484167_Chip-Seq_Bcells_Mouse1.50851240
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49922888
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49698641
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47322876
43XRN2_22483619_ChIP-Seq_HELA_Human1.47298450
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45181995
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44739372
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43891264
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.43605083
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.42557691
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41932456
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41583260
51BCOR_27268052_Chip-Seq_Bcells_Human1.40049511
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39981817
53DCP1A_22483619_ChIP-Seq_HELA_Human1.39846602
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38262048
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37516305
56VDR_22108803_ChIP-Seq_LS180_Human1.36690821
57MAF_26560356_Chip-Seq_TH1_Human1.36495974
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.36295028
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35536490
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34486340
61PHF8_20622854_ChIP-Seq_HELA_Human1.33354547
62RACK7_27058665_Chip-Seq_MCF-7_Human1.31823950
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.29409397
64VDR_24763502_ChIP-Seq_THP-1_Human1.26102490
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25510341
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.23665414
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23260567
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.23018384
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22983228
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.22749400
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20310169
72TTF2_22483619_ChIP-Seq_HELA_Human1.20001691
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19980324
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19566759
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17278605
76MAF_26560356_Chip-Seq_TH2_Human1.15690841
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15107640
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.11319195
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.11261385
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.10390769
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.09693343
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09500414
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09464349
84CTCF_21964334_Chip-Seq_Bcells_Human1.08755710
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07468085
86SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07003465
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06653949
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06028618
89STAT1_20625510_ChIP-Seq_HELA_Human1.05609040
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05600305
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04410867
92NCOR1_26117541_ChIP-Seq_K562_Human1.03231546
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03153022
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03086023
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03067843
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.02016876
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01793079
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01093702
99CLOCK_20551151_ChIP-Seq_293T_Human1.00506315
100SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99781563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.90377185
2MP0009384_cardiac_valve_regurgitation3.36167933
3MP0000749_muscle_degeneration3.35345753
4MP0005397_hematopoietic_system_phenotyp3.08621262
5MP0001545_abnormal_hematopoietic_system3.08621262
6MP0005464_abnormal_platelet_physiology2.92145031
7MP0002653_abnormal_ependyma_morphology2.70471846
8MP0002282_abnormal_trachea_morphology2.62299135
9MP0005451_abnormal_body_composition2.56100169
10MP0003828_pulmonary_edema2.55391559
11MP0003191_abnormal_cellular_cholesterol2.54521327
12MP0005058_abnormal_lysosome_morphology2.49740062
13MP0008007_abnormal_cellular_replicative2.43460855
14MP0000465_gastrointestinal_hemorrhage2.30990899
15MP0009278_abnormal_bone_marrow2.30232955
16MP0003172_abnormal_lysosome_physiology2.16380988
17MP0005257_abnormal_intraocular_pressure2.02543262
18MP0008961_abnormal_basal_metabolism1.99469962
19MP0000343_altered_response_to1.98989762
20MP0004272_abnormal_basement_membrane1.93314152
21MP0006054_spinal_hemorrhage1.90524456
22MP0004808_abnormal_hematopoietic_stem1.83390483
23MP0004142_abnormal_muscle_tone1.82010358
24MP0000566_synostosis1.77152028
25MP0000751_myopathy1.77149558
26MP0004510_myositis1.75567719
27MP0005623_abnormal_meninges_morphology1.69839572
28MP0003718_maternal_effect1.67906784
29MP0009379_abnormal_foot_pigmentation1.60169180
30MP0005394_taste/olfaction_phenotype1.56945165
31MP0005499_abnormal_olfactory_system1.56945165
32MP0003315_abnormal_perineum_morphology1.54041732
33MP0003436_decreased_susceptibility_to1.48003277
34MP0003950_abnormal_plasma_membrane1.47100661
35MP0004742_abnormal_vestibular_system1.37707077
36MP0003566_abnormal_cell_adhesion1.33777368
37MP0001853_heart_inflammation1.33619962
38MP0009250_abnormal_appendicular_skeleto1.29399579
39MP0000358_abnormal_cell_content/1.27023875
40MP0001542_abnormal_bone_strength1.26833287
41MP0003329_amyloid_beta_deposits1.20888525
42MP0005584_abnormal_enzyme/coenzyme_acti1.20417522
43MP0002736_abnormal_nociception_after1.19705652
44MP0005165_increased_susceptibility_to1.18021741
45MP0006138_congestive_heart_failure1.12329875
46MP0003786_premature_aging1.12306949
47MP0000750_abnormal_muscle_regeneration1.10778260
48MP0008789_abnormal_olfactory_epithelium1.09110480
49MP0002733_abnormal_thermal_nociception1.07376434
50MP0003656_abnormal_erythrocyte_physiolo1.06046458
51MP0000003_abnormal_adipose_tissue1.03757509
52MP0000516_abnormal_urinary_system0.99981139
53MP0005367_renal/urinary_system_phenotyp0.99981139
54MP0003959_abnormal_lean_body0.99628200
55MP0003137_abnormal_impulse_conducting0.96325684
56MP0004185_abnormal_adipocyte_glucose0.96122254
57MP0008775_abnormal_heart_ventricle0.95907585
58MP0001968_abnormal_touch/_nociception0.94457862
59MP0001851_eye_inflammation0.93507278
60MP0002148_abnormal_hypersensitivity_rea0.92722813
61MP0003787_abnormal_imprinting0.92616669
62MP0006072_abnormal_retinal_apoptosis0.91753266
63MP0002089_abnormal_postnatal_growth/wei0.90772224
64MP0000049_abnormal_middle_ear0.90510918
65MP0001984_abnormal_olfaction0.87421246
66MP0000747_muscle_weakness0.85424833
67MP0002332_abnormal_exercise_endurance0.85387549
68MP0005164_abnormal_response_to0.83467791
69MP0008995_early_reproductive_senescence0.82604457
70MP0010030_abnormal_orbit_morphology0.82420876
71MP0000534_abnormal_ureter_morphology0.82108870
72MP0000490_abnormal_crypts_of0.80942581
73MP0000604_amyloidosis0.79500786
74MP0005025_abnormal_response_to0.77671466
75MP0002396_abnormal_hematopoietic_system0.75808587
76MP0009931_abnormal_skin_appearance0.74254864
77MP0002419_abnormal_innate_immunity0.74188461
78MP0001986_abnormal_taste_sensitivity0.73783698
79MP0000689_abnormal_spleen_morphology0.72280388
80MP0001533_abnormal_skeleton_physiology0.72280377
81MP0001835_abnormal_antigen_presentation0.71481818
82MP0000249_abnormal_blood_vessel0.70596669
83MP0006036_abnormal_mitochondrial_physio0.69290210
84MP0003866_abnormal_defecation0.68558987
85MP0008877_abnormal_DNA_methylation0.67046296
86MP0008260_abnormal_autophagy0.65672258
87MP0009333_abnormal_splenocyte_physiolog0.62407929
88MP0001849_ear_inflammation0.62127824
89MP0005595_abnormal_vascular_smooth0.60348416
90MP0000350_abnormal_cell_proliferation0.60282564
91MP0005390_skeleton_phenotype0.60116209
92MP0000230_abnormal_systemic_arterial0.59137080
93MP0002398_abnormal_bone_marrow0.58979325
94MP0005384_cellular_phenotype0.58794963
95MP0002452_abnormal_antigen_presenting0.58120141
96MP0005330_cardiomyopathy0.57401937
97MP0001663_abnormal_digestive_system0.56775333
98MP0005023_abnormal_wound_healing0.56649378
99MP0002420_abnormal_adaptive_immunity0.55102797
100MP0002723_abnormal_immune_serum0.55033333

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)5.68285641
2Focal motor seizures (HP:0011153)5.29745935
311 pairs of ribs (HP:0000878)5.19365352
4Axonal loss (HP:0003447)4.23547161
5Vacuolated lymphocytes (HP:0001922)3.77737051
6Bronchomalacia (HP:0002780)3.69467019
7Chronic otitis media (HP:0000389)3.57887967
8Hypoplastic iliac wings (HP:0002866)3.57776148
9Dysostosis multiplex (HP:0000943)3.47991966
10Male infertility (HP:0003251)3.37415686
11Nuclear cataract (HP:0100018)3.20850763
12Mesangial abnormality (HP:0001966)3.19606962
13Petechiae (HP:0000967)3.18416353
14Distal lower limb muscle weakness (HP:0009053)3.13220694
15Dialeptic seizures (HP:0011146)3.13050898
16Progressive hearing impairment (HP:0001730)3.04929437
17Glossoptosis (HP:0000162)2.98904338
18Delusions (HP:0000746)2.98349816
19Absence seizures (HP:0002121)2.92635068
20Thin ribs (HP:0000883)2.77635177
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.77100460
22Prominent supraorbital ridges (HP:0000336)2.75232597
23Abnormality of polysaccharide metabolism (HP:0011012)2.67083580
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67083580
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67083580
26Type II lissencephaly (HP:0007260)2.62074184
27Mucopolysacchariduria (HP:0008155)2.59988008
28Urinary glycosaminoglycan excretion (HP:0003541)2.59988008
29Xerostomia (HP:0000217)2.58363967
30Conjugated hyperbilirubinemia (HP:0002908)2.52817521
31Distal lower limb amyotrophy (HP:0008944)2.52700863
32Increased cerebral lipofuscin (HP:0011813)2.50997844
33Progressive sensorineural hearing impairment (HP:0000408)2.49995428
34Upper limb muscle weakness (HP:0003484)2.49949474
35Cerebral hypomyelination (HP:0006808)2.43190752
36Missing ribs (HP:0000921)2.42316414
37Molar tooth sign on MRI (HP:0002419)2.38339561
38Abnormality of midbrain morphology (HP:0002418)2.38339561
39Personality changes (HP:0000751)2.36704872
40Broad face (HP:0000283)2.35171185
41Premature ovarian failure (HP:0008209)2.34928961
42Glucose intolerance (HP:0000833)2.32491801
43Increased intramyocellular lipid droplets (HP:0012240)2.30626687
44Abnormality of skull ossification (HP:0002703)2.29001006
45Lower limb amyotrophy (HP:0007210)2.28378384
46Testicular atrophy (HP:0000029)2.25520185
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19714333
48Vertebral hypoplasia (HP:0008417)2.19714333
49Abnormality of iron homeostasis (HP:0011031)2.17876376
50Metaphyseal irregularity (HP:0003025)2.17778675
51Progressive neurologic deterioration (HP:0002344)2.17000351
52Increased serum ferritin (HP:0003281)2.16148008
53Hypoplastic ilia (HP:0000946)2.15899766
54Unsteady gait (HP:0002317)2.12368977
55Abnormal number of erythroid precursors (HP:0012131)2.12325106
56Generalized aminoaciduria (HP:0002909)2.11835104
57Neonatal short-limb short stature (HP:0008921)2.10526779
58Decreased skull ossification (HP:0004331)2.09938407
59Easy fatigability (HP:0003388)2.09164033
60Abnormality of cells of the erythroid lineage (HP:0012130)2.08413095
61Retinal dysplasia (HP:0007973)2.08249225
62Ovoid vertebral bodies (HP:0003300)2.07961964
63Muscle stiffness (HP:0003552)2.07454337
64Diaphragmatic weakness (HP:0009113)2.06877097
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05240583
66True hermaphroditism (HP:0010459)2.03809094
67Purpura (HP:0000979)2.02795218
68Increased muscle lipid content (HP:0009058)2.02107072
69Menorrhagia (HP:0000132)2.01563845
70Inability to walk (HP:0002540)2.01133358
71Rapidly progressive (HP:0003678)2.00246518
72Trismus (HP:0000211)2.00170903
73Abnormality of the sella turcica (HP:0002679)1.98369084
74J-shaped sella turcica (HP:0002680)1.95225649
75Progressive inability to walk (HP:0002505)1.95018874
76Focal segmental glomerulosclerosis (HP:0000097)1.93178561
77Joint stiffness (HP:0001387)1.89187677
78Disproportionate short-trunk short stature (HP:0003521)1.87915321
79Morphological abnormality of the inner ear (HP:0011390)1.87893430
80Reduced antithrombin III activity (HP:0001976)1.85961939
81Tracheomalacia (HP:0002779)1.85836367
82Elevated erythrocyte sedimentation rate (HP:0003565)1.85719448
83Bradycardia (HP:0001662)1.85448833
84Generalized amyotrophy (HP:0003700)1.85107552
85Generalized tonic-clonic seizures (HP:0002069)1.82831072
86Absent/shortened dynein arms (HP:0200106)1.81009693
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.81009693
88Hepatic necrosis (HP:0002605)1.80734771
89Renal Fanconi syndrome (HP:0001994)1.80606389
90Delayed CNS myelination (HP:0002188)1.80409081
91Epistaxis (HP:0000421)1.80120604
92Abnormality of transition element cation homeostasis (HP:0011030)1.78702414
93Psychosis (HP:0000709)1.78458937
94Hypertensive crisis (HP:0100735)1.77749374
95Limb-girdle muscle atrophy (HP:0003797)1.75176979
96Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70890950
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70890950
98Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.69962456
99Neonatal respiratory distress (HP:0002643)1.69520174
100Hepatocellular necrosis (HP:0001404)1.68746977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK15.52169924
2TSSK65.37048695
3TESK13.74069644
4SCYL23.12829826
5PNCK3.06243592
6TAF12.98026713
7MST42.96551338
8MAP2K72.78295902
9WEE12.64089014
10VRK22.57727569
11NME22.27870643
12MAPKAPK52.03650663
13STK161.99022909
14TIE11.94658211
15LIMK11.86759143
16MAPK151.70739972
17MAP3K111.68195367
18MAP4K21.65995863
19EPHA21.62419292
20CAMKK21.53542159
21IRAK31.44352197
22MOS1.42868389
23LATS21.38433057
24DAPK21.27662661
25EPHA31.20048999
26ICK1.17494925
27TESK21.13392832
28MAP3K11.10749991
29TAOK31.08697018
30BRSK21.06195764
31CDK81.05482353
32MAP3K121.01936261
33MAPKAPK30.98934642
34BCKDK0.97549427
35PIM20.96822067
36CCNB10.95139383
37PTK2B0.94923059
38ARAF0.92745464
39MAP2K30.92691574
40MARK10.92629579
41TBK10.92379878
42ABL20.92051949
43MAP3K60.88972113
44SMG10.84192612
45CLK10.80923053
46DAPK10.77799239
47LMTK20.72606121
48ZAK0.72226264
49MAP4K10.71258899
50FES0.71104852
51ERBB40.71038095
52MAP3K90.69414387
53BRSK10.66857658
54EPHB10.65128415
55LRRK20.63543099
56KDR0.61781737
57AURKA0.61609064
58PRKD20.59378980
59PAK40.58885961
60MUSK0.57702908
61TAOK10.56627124
62ERN10.55889610
63ZAP700.55226752
64SIK10.55052427
65PAK20.54440580
66MAP2K20.53551022
67VRK10.50278888
68MARK30.49038816
69NEK20.48569287
70ADRBK20.45646131
71RPS6KB20.45578614
72DYRK30.44861281
73STK100.43570449
74BUB10.43427311
75EIF2AK20.40753673
76TTN0.40048491
77PAK10.39642537
78KSR10.38094546
79MAPK130.36648359
80MELK0.36332329
81ADRBK10.36175334
82MAPKAPK20.35289117
83MST1R0.32645986
84TEC0.31819852
85TYK20.31530425
86STK110.30516579
87HIPK20.30455950
88PRKG20.30080140
89MAP2K40.29934602
90CSF1R0.29261912
91ROCK10.27947935
92PKN10.27497499
93PRKCI0.26943158
94JAK30.26652103
95TRPM70.26214739
96TGFBR20.25697293
97MYLK0.24516573
98GRK70.24081131
99PLK30.23719256
100MAPK110.22462357

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.37519527
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.38620971
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.92319155
4Antigen processing and presentation_Homo sapiens_hsa046122.62457719
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61013925
6Oxidative phosphorylation_Homo sapiens_hsa001902.46601538
7Parkinsons disease_Homo sapiens_hsa050122.43055070
8Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.31317436
9Fructose and mannose metabolism_Homo sapiens_hsa000512.28500699
10Ribosome_Homo sapiens_hsa030102.23558586
11Alzheimers disease_Homo sapiens_hsa050102.09910683
12Huntingtons disease_Homo sapiens_hsa050161.84984492
13Notch signaling pathway_Homo sapiens_hsa043301.81701871
14Other glycan degradation_Homo sapiens_hsa005111.72198973
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63145671
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54450352
17Bladder cancer_Homo sapiens_hsa052191.53767579
18Regulation of autophagy_Homo sapiens_hsa041401.49789429
19Lysosome_Homo sapiens_hsa041421.49445840
20Butanoate metabolism_Homo sapiens_hsa006501.48469291
21Legionellosis_Homo sapiens_hsa051341.43587269
22Platelet activation_Homo sapiens_hsa046111.32516078
23Asthma_Homo sapiens_hsa053101.30996394
24Spliceosome_Homo sapiens_hsa030401.27332117
25Hematopoietic cell lineage_Homo sapiens_hsa046401.25737539
26Pyrimidine metabolism_Homo sapiens_hsa002401.25711566
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25023069
28Cocaine addiction_Homo sapiens_hsa050301.17797602
29Viral myocarditis_Homo sapiens_hsa054161.16846896
30Prion diseases_Homo sapiens_hsa050201.16604324
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.13292850
32Toxoplasmosis_Homo sapiens_hsa051451.13124092
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13087491
34Estrogen signaling pathway_Homo sapiens_hsa049151.10926537
35Protein export_Homo sapiens_hsa030601.06202273
36Galactose metabolism_Homo sapiens_hsa000521.05274704
37Autoimmune thyroid disease_Homo sapiens_hsa053201.02940580
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98706861
39Cardiac muscle contraction_Homo sapiens_hsa042600.93638324
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91885549
41VEGF signaling pathway_Homo sapiens_hsa043700.91747954
42Epstein-Barr virus infection_Homo sapiens_hsa051690.90440830
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89956846
44Phagosome_Homo sapiens_hsa041450.87135317
45Arachidonic acid metabolism_Homo sapiens_hsa005900.86189875
46Graft-versus-host disease_Homo sapiens_hsa053320.84160629
47Renin secretion_Homo sapiens_hsa049240.81910988
48Proteasome_Homo sapiens_hsa030500.81725620
49Allograft rejection_Homo sapiens_hsa053300.81652129
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81104043
51N-Glycan biosynthesis_Homo sapiens_hsa005100.78511770
52Pentose phosphate pathway_Homo sapiens_hsa000300.73916367
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72829846
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72548335
55Influenza A_Homo sapiens_hsa051640.71985790
56Type I diabetes mellitus_Homo sapiens_hsa049400.69816435
57Ovarian steroidogenesis_Homo sapiens_hsa049130.68023780
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65853993
59RNA polymerase_Homo sapiens_hsa030200.65144303
60MAPK signaling pathway_Homo sapiens_hsa040100.63774773
61Endocytosis_Homo sapiens_hsa041440.63533865
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59752775
63Ether lipid metabolism_Homo sapiens_hsa005650.58379123
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56499993
65Dopaminergic synapse_Homo sapiens_hsa047280.56469848
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56343260
67Tuberculosis_Homo sapiens_hsa051520.55432967
68Serotonergic synapse_Homo sapiens_hsa047260.54689100
69Alcoholism_Homo sapiens_hsa050340.52773835
70Fatty acid elongation_Homo sapiens_hsa000620.52160897
71African trypanosomiasis_Homo sapiens_hsa051430.49910622
72Taste transduction_Homo sapiens_hsa047420.49098727
73Leishmaniasis_Homo sapiens_hsa051400.47552801
74Sulfur relay system_Homo sapiens_hsa041220.47506103
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.46164657
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45895110
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45303459
78Rheumatoid arthritis_Homo sapiens_hsa053230.45182900
79Homologous recombination_Homo sapiens_hsa034400.44724055
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44091931
81Dilated cardiomyopathy_Homo sapiens_hsa054140.43800180
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42296122
83Purine metabolism_Homo sapiens_hsa002300.40439507
84Basal transcription factors_Homo sapiens_hsa030220.40251037
85Measles_Homo sapiens_hsa051620.40136715
86Herpes simplex infection_Homo sapiens_hsa051680.39895870
87Metabolic pathways_Homo sapiens_hsa011000.38869465
88Amphetamine addiction_Homo sapiens_hsa050310.37298650
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.36779448
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35831863
91Biosynthesis of amino acids_Homo sapiens_hsa012300.34620627
92Peroxisome_Homo sapiens_hsa041460.33999471
93GnRH signaling pathway_Homo sapiens_hsa049120.33760956
94Calcium signaling pathway_Homo sapiens_hsa040200.33306463
95Gap junction_Homo sapiens_hsa045400.31623067
96Circadian entrainment_Homo sapiens_hsa047130.31457074
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.30999972
98Shigellosis_Homo sapiens_hsa051310.30912801
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30845929
100Folate biosynthesis_Homo sapiens_hsa007900.30446088

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