CDC40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)4.17229376
2cell wall macromolecule catabolic process (GO:0016998)4.08770457
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.04086019
4cell wall macromolecule metabolic process (GO:0044036)4.01064586
5DNA ligation (GO:0006266)3.94403178
6DNA topological change (GO:0006265)3.87272881
7regulation of mitotic spindle checkpoint (GO:1903504)3.83268026
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.83268026
9nuclear pore complex assembly (GO:0051292)3.81904059
10mitotic sister chromatid cohesion (GO:0007064)3.78357554
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75599878
12leukocyte aggregation (GO:0070486)3.74611964
13regulation of B cell receptor signaling pathway (GO:0050855)3.71234604
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71175143
15V(D)J recombination (GO:0033151)3.68492559
16DNA deamination (GO:0045006)3.67148418
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65341014
18translational termination (GO:0006415)3.64356111
19cellular response to ethanol (GO:0071361)3.59510084
20viral transcription (GO:0019083)3.58829710
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57666314
22negative regulation of phagocytosis (GO:0050765)3.56074646
23kinetochore assembly (GO:0051382)3.55247711
24DNA double-strand break processing (GO:0000729)3.51022157
25mitotic metaphase plate congression (GO:0007080)3.44845906
26mast cell activation (GO:0045576)3.41535734
27ribosomal small subunit biogenesis (GO:0042274)3.38360304
28ribosomal large subunit biogenesis (GO:0042273)3.37480533
29establishment of chromosome localization (GO:0051303)3.34939648
30germinal center formation (GO:0002467)3.33175701
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.29764456
32pore complex assembly (GO:0046931)3.29206422
33metaphase plate congression (GO:0051310)3.27368026
34response to pheromone (GO:0019236)3.26024255
35regulation of DNA endoreduplication (GO:0032875)3.25298789
36pseudouridine synthesis (GO:0001522)3.22509713
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20466032
38cotranslational protein targeting to membrane (GO:0006613)3.19496868
39DNA unwinding involved in DNA replication (GO:0006268)3.18901859
40organelle disassembly (GO:1903008)3.18154821
41protein targeting to ER (GO:0045047)3.16300960
42nuclear pore organization (GO:0006999)3.12683432
43mast cell degranulation (GO:0043303)3.12522813
44mast cell activation involved in immune response (GO:0002279)3.12522813
45ribosomal small subunit assembly (GO:0000028)3.11624776
46histone mRNA metabolic process (GO:0008334)3.09377760
47centriole replication (GO:0007099)3.09275679
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08567204
49mitotic chromosome condensation (GO:0007076)3.06652883
50transcription from mitochondrial promoter (GO:0006390)3.06030510
51somatic cell DNA recombination (GO:0016444)3.04556513
52somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.04556513
53poly(A)+ mRNA export from nucleus (GO:0016973)3.04522623
54B cell receptor signaling pathway (GO:0050853)3.01319083
55attachment of spindle microtubules to kinetochore (GO:0008608)2.98197505
56translational initiation (GO:0006413)2.97424353
57protein K11-linked deubiquitination (GO:0035871)2.96499422
58T cell homeostasis (GO:0043029)2.95021726
59translational elongation (GO:0006414)2.94950819
60positive regulation of histone H3-K4 methylation (GO:0051571)2.94360042
61CENP-A containing nucleosome assembly (GO:0034080)2.94214805
62DNA demethylation (GO:0080111)2.93792105
63cellular response to interleukin-15 (GO:0071350)2.90827713
64neural tube formation (GO:0001841)2.90644165
65protein localization to endoplasmic reticulum (GO:0070972)2.90398336
66DNA replication initiation (GO:0006270)2.89848717
67ribonucleoprotein complex disassembly (GO:0032988)2.88879132
68monoubiquitinated protein deubiquitination (GO:0035520)2.88537742
69sister chromatid cohesion (GO:0007062)2.87323294
70macrophage differentiation (GO:0030225)2.86894818
71regulation of meiosis I (GO:0060631)2.85525299
72histone mRNA catabolic process (GO:0071044)2.85467419
73mitotic sister chromatid segregation (GO:0000070)2.84944783
74somatic diversification of immune receptors (GO:0002200)2.84137238
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.83762743
76NADH dehydrogenase complex assembly (GO:0010257)2.83762743
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83762743
78regulation of spindle organization (GO:0090224)2.83276190
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82836309
80protein localization to kinetochore (GO:0034501)2.81609369
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80156607
82DNA replication checkpoint (GO:0000076)2.80089871
83chaperone-mediated protein transport (GO:0072321)2.79513967
84DNA strand elongation involved in DNA replication (GO:0006271)2.79378102
85meiotic chromosome segregation (GO:0045132)2.77792232
86histone H2A monoubiquitination (GO:0035518)2.77384674
87sister chromatid segregation (GO:0000819)2.77335101
88spliceosomal complex assembly (GO:0000245)2.76422367
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75070229
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72818505
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72818505
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.72818505
93neutrophil activation involved in immune response (GO:0002283)2.72237069
94nucleobase biosynthetic process (GO:0046112)2.71294346
95respiratory chain complex IV assembly (GO:0008535)2.70761008
96protein K6-linked ubiquitination (GO:0085020)2.70509968
97positive regulation of chromosome segregation (GO:0051984)2.70466980
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70167375
99chromatin remodeling at centromere (GO:0031055)2.69893886
100positive regulation of gamma-delta T cell activation (GO:0046645)2.67628310
101viral mRNA export from host cell nucleus (GO:0046784)2.67219279
102piRNA metabolic process (GO:0034587)2.66260539
103negative regulation of interleukin-1 beta production (GO:0032691)2.64987960
104protein complex biogenesis (GO:0070271)2.64860990
105T cell migration (GO:0072678)2.63944409
106DNA strand elongation (GO:0022616)2.63910714
107histone H2A ubiquitination (GO:0033522)2.63616431
108rRNA metabolic process (GO:0016072)2.63575489
109viral life cycle (GO:0019058)2.63414387
110IMP biosynthetic process (GO:0006188)2.63068514
111ribosome assembly (GO:0042255)2.63033306
112mitotic nuclear envelope disassembly (GO:0007077)2.62527557
113positive regulation of B cell differentiation (GO:0045579)2.62237371
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.62162339
115mitochondrial respiratory chain complex assembly (GO:0033108)2.62080055
116rRNA processing (GO:0006364)2.61991898
117ATP synthesis coupled proton transport (GO:0015986)2.61825222
118energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61825222
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61467088
120cellular protein complex disassembly (GO:0043624)2.60309891
121B cell homeostasis (GO:0001782)2.60307744
122response to interleukin-15 (GO:0070672)2.60079404
123megakaryocyte development (GO:0035855)2.59809266
124regulation of B cell differentiation (GO:0045577)2.58850888
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.58077938
126termination of RNA polymerase III transcription (GO:0006386)2.58077938
127translation (GO:0006412)2.56642237
128DNA replication-dependent nucleosome organization (GO:0034723)2.55066794
129DNA replication-dependent nucleosome assembly (GO:0006335)2.55066794
130somatic recombination of immunoglobulin gene segments (GO:0016447)2.54418309
131telomere maintenance via recombination (GO:0000722)2.54201127
132regulation of helicase activity (GO:0051095)2.54182048
133rRNA catabolic process (GO:0016075)2.54064043
134purine nucleobase biosynthetic process (GO:0009113)2.53658611
135peptidyl-threonine dephosphorylation (GO:0035970)2.53283165
136recombinational repair (GO:0000725)2.53214158
137rRNA methylation (GO:0031167)2.52958857
138DNA replication-independent nucleosome assembly (GO:0006336)2.52890202
139DNA replication-independent nucleosome organization (GO:0034724)2.52890202
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52693096
141double-strand break repair via homologous recombination (GO:0000724)2.52596379
142positive regulation of granulocyte differentiation (GO:0030854)2.51520460
143regulation of T cell receptor signaling pathway (GO:0050856)2.51432908
144formation of translation preinitiation complex (GO:0001731)2.50764157
145interferon-gamma production (GO:0032609)2.50724029
146mitotic recombination (GO:0006312)2.50467661
147regulation of DNA-dependent DNA replication (GO:0090329)2.49581392
148lymphocyte homeostasis (GO:0002260)2.49221734
149mRNA catabolic process (GO:0006402)2.49078279
150DNA dealkylation (GO:0035510)2.48940842
151nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48467273
152regulation of translation in response to stress (GO:0043555)2.47435584
153mitochondrial RNA metabolic process (GO:0000959)2.47304758
154* mRNA export from nucleus (GO:0006406)2.46038300
155nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.45334149
156DNA-dependent DNA replication (GO:0006261)2.44436091
157histone exchange (GO:0043486)2.43291564
158telomere maintenance via semi-conservative replication (GO:0032201)2.42082009
159negative regulation of B cell proliferation (GO:0030889)2.42065541
160cytochrome complex assembly (GO:0017004)2.41278303
161spindle checkpoint (GO:0031577)2.41079629
162DNA catabolic process, exonucleolytic (GO:0000738)2.40744074
163regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.40708069
164rRNA modification (GO:0000154)2.40348689
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.39915850
166maturation of SSU-rRNA (GO:0030490)2.39391827
167somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39254226
168isotype switching (GO:0045190)2.39254226
169somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39254226
170replication fork processing (GO:0031297)2.38933505
171intra-S DNA damage checkpoint (GO:0031573)2.38871833
172telomere maintenance (GO:0000723)2.37882457
173leukocyte degranulation (GO:0043299)2.37764551
174regulation of centriole replication (GO:0046599)2.37666831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.32194475
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.06077231
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80636718
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25413821
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25258860
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15208432
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00960151
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.96408367
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92135677
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74224272
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.70207658
12SCL_19346495_ChIP-Seq_HPC-7_Human2.66896132
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60059234
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56839686
15IGF1R_20145208_ChIP-Seq_DFB_Human2.53047073
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.49584391
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43152389
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30914944
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27182633
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25990258
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.21632125
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.16838340
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13670772
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.11657115
25ZNF274_21170338_ChIP-Seq_K562_Hela2.10634155
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06645055
27GATA1_22025678_ChIP-Seq_K562_Human2.01078331
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.98232767
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97493896
30VDR_23849224_ChIP-Seq_CD4+_Human1.93682071
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93476895
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.91639616
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90216201
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90111628
35ELK1_19687146_ChIP-ChIP_HELA_Human1.88593962
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82835623
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81589287
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77584513
39* SPI1_23547873_ChIP-Seq_NB4_Human1.77215235
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76362012
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.76061659
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.75398009
43P300_19829295_ChIP-Seq_ESCs_Human1.69312467
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65740723
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63095000
46TAF15_26573619_Chip-Seq_HEK293_Human1.63076122
47* FUS_26573619_Chip-Seq_HEK293_Human1.62137811
48FOXP3_21729870_ChIP-Seq_TREG_Human1.59675352
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57605278
50* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55275233
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.54929801
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54706266
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54098569
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52958834
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52573284
56MYB_26560356_Chip-Seq_TH2_Human1.51606474
57ER_23166858_ChIP-Seq_MCF-7_Human1.48916607
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48777500
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48160597
60EWS_26573619_Chip-Seq_HEK293_Human1.47243075
61* EZH2_27294783_Chip-Seq_NPCs_Mouse1.45209048
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44465272
63MYC_22102868_ChIP-Seq_BL_Human1.44233924
64MYB_26560356_Chip-Seq_TH1_Human1.43714267
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43029226
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41774884
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41766894
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41529659
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.40690245
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37874812
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37549523
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37389073
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34482492
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33568820
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32405974
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31364813
77* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31001330
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28708588
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28291111
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27650702
81RUNX_20019798_ChIP-Seq_JUKART_Human1.27008137
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26915109
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26133896
84AR_21909140_ChIP-Seq_LNCAP_Human1.25867405
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.25497994
86GATA3_26560356_Chip-Seq_TH2_Human1.25392842
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24524217
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24219871
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24004056
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20758837
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19796862
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19610821
93CBP_20019798_ChIP-Seq_JUKART_Human1.19610821
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19416046
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17788195
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.17202374
97* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17037774
98XRN2_22483619_ChIP-Seq_HELA_Human1.16097350
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.15991194
100* CRX_20693478_ChIP-Seq_RETINA_Mouse1.15537420
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14829748
102TP53_22573176_ChIP-Seq_HFKS_Human1.12493235
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12114090
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11805066
105IRF1_19129219_ChIP-ChIP_H3396_Human1.10918387
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10577488
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10233599
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07287058
109DCP1A_22483619_ChIP-Seq_HELA_Human1.06736682
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.05055823
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04748172
112* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03168176
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03168071
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02194729
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01074516
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01074516
117SOX2_19829295_ChIP-Seq_ESCs_Human1.00706847
118NANOG_19829295_ChIP-Seq_ESCs_Human1.00706847
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00554923
120* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99893530
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99039703
122* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97965222
123VDR_21846776_ChIP-Seq_THP-1_Human0.97293926
124MYC_18940864_ChIP-ChIP_HL60_Human0.97041854
125TTF2_22483619_ChIP-Seq_HELA_Human0.97031106
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96751147
127CDX2_22108803_ChIP-Seq_LS180_Human0.95823430
128PU_27001747_Chip-Seq_BMDM_Mouse0.94808837
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94265621
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.94265621
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93722826
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93043635
133SRF_21415370_ChIP-Seq_HL-1_Mouse0.92356119
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92233937
135AR_20517297_ChIP-Seq_VCAP_Human0.92063477
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92018510
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.91505529
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91394422
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.91015725
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90969316
141GBX2_23144817_ChIP-Seq_PC3_Human0.90865032
142KDM5A_27292631_Chip-Seq_BREAST_Human0.90494360
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90284763
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84763631
145GABP_19822575_ChIP-Seq_HepG2_Human0.84001261
146GATA3_27048872_Chip-Seq_THYMUS_Human0.83233284
147VDR_22108803_ChIP-Seq_LS180_Human0.82847901
148SALL4_22934838_ChIP-ChIP_CD34+_Human0.81745483
149VDR_24763502_ChIP-Seq_THP-1_Human0.81548468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.30695963
2MP0002396_abnormal_hematopoietic_system3.69740507
3MP0008057_abnormal_DNA_replication3.68300418
4MP0006054_spinal_hemorrhage3.62773101
5MP0008877_abnormal_DNA_methylation3.40719187
6MP0010094_abnormal_chromosome_stability3.22023203
7MP0005409_darkened_coat_color2.93249734
8MP0001835_abnormal_antigen_presentation2.85914976
9MP0006292_abnormal_olfactory_placode2.60484751
10MP0003693_abnormal_embryo_hatching2.53944172
11MP0003763_abnormal_thymus_physiology2.52385144
12MP0003077_abnormal_cell_cycle2.44830521
13MP0005671_abnormal_response_to2.37584924
14MP0008058_abnormal_DNA_repair2.36906369
15MP0003880_abnormal_central_pattern2.36539815
16MP0003787_abnormal_imprinting2.32860057
17MP0004808_abnormal_hematopoietic_stem2.28312075
18MP0003111_abnormal_nucleus_morphology2.22152370
19MP0002398_abnormal_bone_marrow2.17823541
20MP0006072_abnormal_retinal_apoptosis2.14207172
21MP0001800_abnormal_humoral_immune2.12838249
22MP0003436_decreased_susceptibility_to2.04558316
23MP0004957_abnormal_blastocyst_morpholog2.02560864
24MP0002420_abnormal_adaptive_immunity1.99195055
25MP0002452_abnormal_antigen_presenting1.97507256
26MP0008007_abnormal_cellular_replicative1.96164096
27MP0001819_abnormal_immune_cell1.94335113
28MP0000685_abnormal_immune_system1.91349622
29MP0001545_abnormal_hematopoietic_system1.88487653
30MP0005397_hematopoietic_system_phenotyp1.88487653
31MP0002723_abnormal_immune_serum1.86591482
32MP0000703_abnormal_thymus_morphology1.83336647
33MP0000716_abnormal_immune_system1.80459171
34MP0000689_abnormal_spleen_morphology1.80411116
35MP0003718_maternal_effect1.79335062
36MP0005000_abnormal_immune_tolerance1.74799565
37MP0002722_abnormal_immune_system1.74796535
38MP0002148_abnormal_hypersensitivity_rea1.74198911
39MP0002277_abnormal_respiratory_mucosa1.73227013
40MP0009785_altered_susceptibility_to1.71165956
41MP0002419_abnormal_innate_immunity1.68545248
42MP0005025_abnormal_response_to1.64013599
43MP0002837_dystrophic_cardiac_calcinosis1.61080205
44MP0000465_gastrointestinal_hemorrhage1.59263597
45MP0005387_immune_system_phenotype1.58219739
46MP0001790_abnormal_immune_system1.58219739
47MP0002876_abnormal_thyroid_physiology1.56023255
48MP0002429_abnormal_blood_cell1.54854834
49MP0009333_abnormal_splenocyte_physiolog1.49451140
50MP0008995_early_reproductive_senescence1.48241897
51MP0000015_abnormal_ear_pigmentation1.47179837
52MP0010307_abnormal_tumor_latency1.45171387
53MP0003890_abnormal_embryonic-extraembry1.44465391
54MP0004147_increased_porphyrin_level1.43536582
55MP0005174_abnormal_tail_pigmentation1.42758278
56MP0010352_gastrointestinal_tract_polyps1.40644520
57MP0003195_calcinosis1.40435612
58MP0001853_heart_inflammation1.36520709
59MP0000490_abnormal_crypts_of1.34191197
60MP0003567_abnormal_fetal_cardiomyocyte1.33860268
61MP0002006_tumorigenesis1.33060773
62MP0002009_preneoplasia1.31844880
63MP0005464_abnormal_platelet_physiology1.31833597
64MP0005253_abnormal_eye_physiology1.31262680
65MP0001293_anophthalmia1.29392594
66MP0002166_altered_tumor_susceptibility1.28808668
67MP0001851_eye_inflammation1.25271447
68MP0001188_hyperpigmentation1.23903490
69MP0002405_respiratory_system_inflammati1.23160770
70MP0004142_abnormal_muscle_tone1.22662875
71MP0003136_yellow_coat_color1.22279795
72MP0010155_abnormal_intestine_physiology1.20464705
73MP0005551_abnormal_eye_electrophysiolog1.19214009
74MP0009379_abnormal_foot_pigmentation1.16971626
75MP0002019_abnormal_tumor_incidence1.16182195
76MP0001929_abnormal_gametogenesis1.15476086
77MP0001915_intracranial_hemorrhage1.11949590
78MP0005075_abnormal_melanosome_morpholog1.10270415
79MP0000631_abnormal_neuroendocrine_gland1.08151942
80MP0005408_hypopigmentation1.07257651
81MP0006036_abnormal_mitochondrial_physio1.06953496
82MP0003252_abnormal_bile_duct1.06317979
83MP0002095_abnormal_skin_pigmentation1.04833615
84MP0009697_abnormal_copulation1.04753844
85MP0003806_abnormal_nucleotide_metabolis1.03141543
86MP0002938_white_spotting1.01761448
87MP0005310_abnormal_salivary_gland1.00570405
88MP0002163_abnormal_gland_morphology1.00409215
89MP0001986_abnormal_taste_sensitivity0.99434779
90MP0003950_abnormal_plasma_membrane0.98511534
91MP0001873_stomach_inflammation0.98243724
92MP0002928_abnormal_bile_duct0.96327230
93MP0008932_abnormal_embryonic_tissue0.96168171
94MP0000350_abnormal_cell_proliferation0.95478071
95MP0009046_muscle_twitch0.90775122
96MP0005646_abnormal_pituitary_gland0.90126658
97MP0001845_abnormal_inflammatory_respons0.89888410
98MP0000313_abnormal_cell_death0.89679899
99MP0003866_abnormal_defecation0.89160926
100MP0003786_premature_aging0.88686654
101MP0005084_abnormal_gallbladder_morpholo0.88378116
102MP0004742_abnormal_vestibular_system0.88189778
103MP0000653_abnormal_sex_gland0.87843044
104MP0000681_abnormal_thyroid_gland0.87608292
105MP0005410_abnormal_fertilization0.86727759
106MP0001730_embryonic_growth_arrest0.86292381
107MP0003724_increased_susceptibility_to0.85651897
108MP0001145_abnormal_male_reproductive0.85649821
109MP0003698_abnormal_male_reproductive0.85248868
110MP0006035_abnormal_mitochondrial_morpho0.85220358
111MP0003943_abnormal_hepatobiliary_system0.84992355
112MP0000372_irregular_coat_pigmentation0.84224247
113MP0003123_paternal_imprinting0.84052878
114MP0004381_abnormal_hair_follicle0.84008594
115MP0003186_abnormal_redox_activity0.83630686
116MP0002210_abnormal_sex_determination0.82810993
117MP0003121_genomic_imprinting0.82012011
118MP0002638_abnormal_pupillary_reflex0.81677483
119MP0003984_embryonic_growth_retardation0.81078954
120MP0001324_abnormal_eye_pigmentation0.78853672
121MP0008872_abnormal_physiological_respon0.77184562
122MP0005389_reproductive_system_phenotype0.76484074
123MP0001533_abnormal_skeleton_physiology0.75563542
124MP0001764_abnormal_homeostasis0.74787152
125MP0002933_joint_inflammation0.73625121
126MP0001697_abnormal_embryo_size0.73483320
127MP0008961_abnormal_basal_metabolism0.73266811
128MP0002088_abnormal_embryonic_growth/wei0.72458214
129MP0005380_embryogenesis_phenotype0.70948154
130MP0001672_abnormal_embryogenesis/_devel0.70948154
131MP0000383_abnormal_hair_follicle0.70905572
132MP0000858_altered_metastatic_potential0.70902871
133MP0003828_pulmonary_edema0.70343899
134MP0005395_other_phenotype0.70297456
135MP0001663_abnormal_digestive_system0.69862406
136MP0006276_abnormal_autonomic_nervous0.69716937
137MP0001984_abnormal_olfaction0.69208680
138MP0004883_abnormal_blood_vessel0.67194114
139MP0003656_abnormal_erythrocyte_physiolo0.65568694
140MP0000604_amyloidosis0.65292016
141MP0003329_amyloid_beta_deposits0.62616688
142MP0002086_abnormal_extraembryonic_tissu0.62382806
143MP0003075_altered_response_to0.60399577
144MP0002102_abnormal_ear_morphology0.60015651
145MP0009764_decreased_sensitivity_to0.58394880
146MP0000249_abnormal_blood_vessel0.56624066
147MP0002089_abnormal_postnatal_growth/wei0.56171656
148MP0008469_abnormal_protein_level0.55869493

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)5.40369038
2Spinal cord lesions (HP:0100561)4.84418012
3Syringomyelia (HP:0003396)4.84418012
4Metaphyseal dysplasia (HP:0100255)4.22894396
5Absent frontal sinuses (HP:0002688)4.11809672
6Volvulus (HP:0002580)3.98890330
7Recurrent abscess formation (HP:0002722)3.94555198
8Recurrent bacterial skin infections (HP:0005406)3.86561858
9Prostate neoplasm (HP:0100787)3.72947322
10Reticulocytopenia (HP:0001896)3.46763332
11Pancreatic cysts (HP:0001737)3.40701717
12Abnormality of the prostate (HP:0008775)3.29638910
13Short middle phalanx of the 5th finger (HP:0004220)3.28486861
14Abnormality of the parietal bone (HP:0002696)3.21734872
15Pancreatic fibrosis (HP:0100732)3.17898877
16Aplastic anemia (HP:0001915)3.04763337
17Abnormality of B cell number (HP:0010975)3.01271000
18B lymphocytopenia (HP:0010976)3.01271000
19Spondylolisthesis (HP:0003302)2.86974985
20IgM deficiency (HP:0002850)2.84775415
21Abnormality of the phalanges of the 2nd finger (HP:0009541)2.84004087
22IgG deficiency (HP:0004315)2.81318131
23Abnormality of midbrain morphology (HP:0002418)2.79523238
24Molar tooth sign on MRI (HP:0002419)2.79523238
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.75811167
26Recurrent viral infections (HP:0004429)2.73267151
27Supernumerary ribs (HP:0005815)2.70816845
28Supernumerary bones of the axial skeleton (HP:0009144)2.66461893
29Stomach cancer (HP:0012126)2.63123253
30Chromsome breakage (HP:0040012)2.62612427
31Abnormal hair whorl (HP:0010721)2.61632073
32Birth length less than 3rd percentile (HP:0003561)2.61222509
33Bile duct proliferation (HP:0001408)2.59691915
34Abnormal biliary tract physiology (HP:0012439)2.59691915
35Thrombocytosis (HP:0001894)2.57088843
36True hermaphroditism (HP:0010459)2.55588122
37Mediastinal lymphadenopathy (HP:0100721)2.55560292
38Constricted visual fields (HP:0001133)2.52783860
39Macrocytic anemia (HP:0001972)2.47582088
40Acute necrotizing encephalopathy (HP:0006965)2.47163308
41Abnormality of chromosome stability (HP:0003220)2.45083082
42Abnormality of the renal cortex (HP:0011035)2.44755289
43Eczematoid dermatitis (HP:0000976)2.41304038
44Abnormality of the fingertips (HP:0001211)2.41217675
45Abnormality of the frontal sinuses (HP:0002687)2.39453428
46Nephronophthisis (HP:0000090)2.38977901
47Hypoplastic iliac wings (HP:0002866)2.35863106
48Facial hemangioma (HP:0000329)2.35050005
49Increased CSF lactate (HP:0002490)2.33652863
50Mitochondrial inheritance (HP:0001427)2.32600089
51Absent thumb (HP:0009777)2.32037033
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.30591114
53Oligodactyly (hands) (HP:0001180)2.29784053
54Progressive macrocephaly (HP:0004481)2.29614080
553-Methylglutaconic aciduria (HP:0003535)2.29040242
56Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.27777267
57Increased hepatocellular lipid droplets (HP:0006565)2.26251866
58Long clavicles (HP:0000890)2.23703597
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.22200598
60Abnormality of lateral ventricle (HP:0030047)2.21583151
61Acute myeloid leukemia (HP:0004808)2.20856152
62Pallor (HP:0000980)2.20316050
63Spontaneous hematomas (HP:0007420)2.18721367
64Exertional dyspnea (HP:0002875)2.18164958
65Congenital stationary night blindness (HP:0007642)2.17761817
66T lymphocytopenia (HP:0005403)2.16629943
67Disinhibition (HP:0000734)2.13677731
68Recurrent skin infections (HP:0001581)2.12854581
69Abnormality of the renal medulla (HP:0100957)2.12339160
70Myositis (HP:0100614)2.11452517
71Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11311022
72Myelodysplasia (HP:0002863)2.10930452
73Lymphoma (HP:0002665)2.09938720
74Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.09813748
75Stenosis of the external auditory canal (HP:0000402)2.09573594
76Methylmalonic acidemia (HP:0002912)2.09303626
77Abnormality of T cell number (HP:0011839)2.08009977
78Abnormality of male internal genitalia (HP:0000022)2.07653110
79Recurrent cutaneous fungal infections (HP:0011370)2.07475652
80Chronic mucocutaneous candidiasis (HP:0002728)2.07475652
81Abnormal number of erythroid precursors (HP:0012131)2.07395092
82Recurrent fungal infections (HP:0002841)2.05600986
83Chronic obstructive pulmonary disease (HP:0006510)2.05048089
84Obstructive lung disease (HP:0006536)2.05048089
85Abnormality of the intervertebral disk (HP:0005108)2.04431444
86Acute encephalopathy (HP:0006846)2.04011726
87Respiratory difficulties (HP:0002880)2.03096306
88Abnormal mitochondria in muscle tissue (HP:0008316)2.02615247
89Medulloblastoma (HP:0002885)2.00271003
90Abnormality of the columella (HP:0009929)2.00151959
91Clubbing of toes (HP:0100760)1.99574667
92Meckel diverticulum (HP:0002245)1.99111818
93Thyroiditis (HP:0100646)1.98772535
94Recurrent pneumonia (HP:0006532)1.98754849
95Capillary hemangiomas (HP:0005306)1.98591847
96Deep philtrum (HP:0002002)1.96511989
97Attenuation of retinal blood vessels (HP:0007843)1.96133884
98Keratoconjunctivitis sicca (HP:0001097)1.95679823
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95666661
100Abnormality of homocysteine metabolism (HP:0010919)1.95363104
101Homocystinuria (HP:0002156)1.95363104
102Fair hair (HP:0002286)1.94836139
103Ectopic kidney (HP:0000086)1.93579965
104Meningitis (HP:0001287)1.93240222
105Colon cancer (HP:0003003)1.92720625
106Abnormal spermatogenesis (HP:0008669)1.92088259
107Abnormality of the ileum (HP:0001549)1.90641203
108Granulocytopenia (HP:0001913)1.90599195
109Elevated erythrocyte sedimentation rate (HP:0003565)1.90142015
110Flared metaphyses (HP:0003015)1.89841134
111Abnormality of methionine metabolism (HP:0010901)1.89638681
112Abnormal protein glycosylation (HP:0012346)1.89404175
113Abnormal glycosylation (HP:0012345)1.89404175
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89404175
115Abnormal protein N-linked glycosylation (HP:0012347)1.89404175
116Abnormality of T cells (HP:0002843)1.89107833
117Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88727878
118Abnormality of cells of the erythroid lineage (HP:0012130)1.87202488
119Eosinophilia (HP:0001880)1.87008386
120Thickened calvaria (HP:0002684)1.86950202
121Inappropriate behavior (HP:0000719)1.86043942
122Abnormality of T cell physiology (HP:0011840)1.85291647
123Congenital, generalized hypertrichosis (HP:0004540)1.84332410
124Panhypogammaglobulinemia (HP:0003139)1.83298136
125Neutropenia (HP:0001875)1.83232076
126Type II lissencephaly (HP:0007260)1.83141188
127Cerebral edema (HP:0002181)1.81919494
128Stomatitis (HP:0010280)1.81887582
129Recurrent bronchitis (HP:0002837)1.81245073
130Abnormality of the preputium (HP:0100587)1.80992439
131Methylmalonic aciduria (HP:0012120)1.80662479
132Medial flaring of the eyebrow (HP:0010747)1.80098983
133Renal Fanconi syndrome (HP:0001994)1.80089271
134Pulmonary fibrosis (HP:0002206)1.79533701
135Breast hypoplasia (HP:0003187)1.79419674
136Renal cortical cysts (HP:0000803)1.79145266
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.78626550
138Abnormality of macular pigmentation (HP:0008002)1.77254692
139Chronic otitis media (HP:0000389)1.76950861
140Asplenia (HP:0001746)1.76634511
141Type I transferrin isoform profile (HP:0003642)1.76432088
142Aplasia/Hypoplasia of the spleen (HP:0010451)1.75590718
143Lipid accumulation in hepatocytes (HP:0006561)1.75406685
144Short tibia (HP:0005736)1.75363538
145Abnormality of DNA repair (HP:0003254)1.74737125
146Short femoral neck (HP:0100864)1.72247360
147Abolished electroretinogram (ERG) (HP:0000550)1.71647956
148Abnormal rod and cone electroretinograms (HP:0008323)1.71603865
149Abnormality of the phalanges of the 5th finger (HP:0004213)1.71031903
150Furrowed tongue (HP:0000221)1.70121561
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70048830
152Keratoconjunctivitis (HP:0001096)1.69839525
153Lymphopenia (HP:0001888)1.69818808
154Cutaneous melanoma (HP:0012056)1.69161401
155Febrile seizures (HP:0002373)1.68924529
156Abnormality of the labia minora (HP:0012880)1.68724322
157Leukocytosis (HP:0001974)1.68438488
158Abnormal lung lobation (HP:0002101)1.68305106
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67357784
160Intestinal atresia (HP:0011100)1.66740289
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66666586
162Increased serum lactate (HP:0002151)1.66587354
163Septo-optic dysplasia (HP:0100842)1.65824342
164Pendular nystagmus (HP:0012043)1.65740134
165Duplicated collecting system (HP:0000081)1.64749661
166Cellulitis (HP:0100658)1.64712886
167Sloping forehead (HP:0000340)1.64477478
168Hepatic necrosis (HP:0002605)1.64457500
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64340983
170Short 4th metacarpal (HP:0010044)1.64340983
171Encephalitis (HP:0002383)1.63264247
172Neoplasm of the adrenal cortex (HP:0100641)1.63253091
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.62151283
174Hypochromic microcytic anemia (HP:0004840)1.61944874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.00224407
2CLK12.58725940
3FRK2.54128299
4EPHA42.51241735
5MAP4K12.50711764
6CDC72.25668370
7BUB12.12338351
8TXK2.10945829
9BMPR22.00254496
10JAK31.93583591
11NUAK11.93522127
12GRK61.90473806
13MKNK21.84359050
14MKNK11.76818990
15LATS11.74863314
16PLK31.74258845
17STK161.73252216
18GRK11.71568661
19TEC1.67695887
20IRAK41.64923201
21BLK1.63820384
22PLK21.62913504
23ACVR1B1.58577123
24EIF2AK31.57945947
25BRSK21.57899591
26FES1.56358157
27EIF2AK11.55662756
28MAP3K121.52625513
29SIK31.51049242
30WEE11.49165266
31VRK11.48785810
32CDK191.47333062
33IRAK21.47242317
34TTK1.46455339
35DAPK11.45683584
36MAP4K21.45369767
37PLK41.43469553
38ADRBK21.39768457
39IRAK11.37647894
40RAF11.35990272
41SRPK11.34179787
42SYK1.30448232
43OXSR11.28081897
44CDK121.25985314
45TAOK31.25639850
46BTK1.24377434
47MAP3K141.22264759
48ATR1.22178484
49PNCK1.17316796
50MAP3K41.14786314
51FLT31.12461263
52CDK41.07627000
53NTRK31.05617914
54PIM11.05269326
55TRIM281.04536480
56STK241.03486191
57KIT1.02862038
58STK101.01697907
59CAMKK21.01488820
60PINK10.99753372
61MAP2K30.99512885
62RPS6KA40.99071885
63MAP3K80.99019027
64NEK20.98633213
65IKBKE0.97945281
66BMPR1B0.97838548
67EEF2K0.97454517
68BRD40.96944290
69TNIK0.95432896
70MARK30.95376025
71TAF10.92542440
72MAP3K130.92001381
73PIM20.88871274
74GRK50.88576554
75CCNB10.87567509
76PASK0.87286223
77LYN0.86292453
78STK40.85611937
79MAP3K60.85040373
80NEK60.84997042
81TSSK60.83667552
82MELK0.82361868
83MAP2K70.82027327
84DYRK1A0.81380801
85EIF2AK20.81192655
86ERBB30.81082391
87NLK0.79953029
88LCK0.79709005
89CHEK20.79565074
90PLK10.79213956
91WNK30.77568826
92ATM0.76828191
93STK390.75991606
94ZAP700.73973862
95BRSK10.72113377
96DYRK20.70087040
97DYRK30.69268768
98TGFBR10.68643110
99STK38L0.68409795
100AURKB0.68181102
101FGFR20.67041172
102ITK0.66846100
103NEK10.66223938
104RPS6KB10.65220283
105PIK3CG0.64975098
106SIK20.64834631
107MST40.63676472
108RPS6KA50.62858508
109CSF1R0.62258989
110CDK80.61723087
111ZAK0.61698516
112CDK70.61317674
113CDK30.61265431
114MAPK130.60966957
115CHEK10.60746208
116IKBKB0.60069618
117BRAF0.58031872
118PRKCQ0.57414490
119IRAK30.57401380
120DAPK20.57364342
121CHUK0.55698470
122TYK20.55524650
123RPS6KA60.55328322
124MAP2K20.55000204
125CDK90.54912678
126CAMK1G0.54785508
127TRPM70.54433944
128PIK3CA0.54080212
129TLK10.53297157
130FGFR30.52232884
131RPS6KL10.51902328
132RPS6KC10.51902328
133PAK30.50856767
134VRK20.49118130
135INSRR0.48489909
136YES10.47826164
137STK30.47677350
138CDK20.47415880
139CDK60.47010348
140SGK20.42583095
141CAMK1D0.39409702

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.25534053
2DNA replication_Homo sapiens_hsa030303.11238569
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66212037
4RNA polymerase_Homo sapiens_hsa030202.65575617
5Protein export_Homo sapiens_hsa030602.64940239
6Oxidative phosphorylation_Homo sapiens_hsa001902.58602738
7Homologous recombination_Homo sapiens_hsa034402.52321752
8RNA degradation_Homo sapiens_hsa030182.39790768
9* Spliceosome_Homo sapiens_hsa030402.38560555
10Primary immunodeficiency_Homo sapiens_hsa053402.30668446
11Mismatch repair_Homo sapiens_hsa034302.19780612
12Cell cycle_Homo sapiens_hsa041102.18694279
13Base excision repair_Homo sapiens_hsa034102.18167465
14Parkinsons disease_Homo sapiens_hsa050122.08631831
15Basal transcription factors_Homo sapiens_hsa030221.91166770
16RNA transport_Homo sapiens_hsa030131.89388586
17Type I diabetes mellitus_Homo sapiens_hsa049401.85244421
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78764445
19Herpes simplex infection_Homo sapiens_hsa051681.77754493
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76778246
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75536191
22Ribosome_Homo sapiens_hsa030101.72765450
23Fanconi anemia pathway_Homo sapiens_hsa034601.71109335
24Leishmaniasis_Homo sapiens_hsa051401.69542543
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.68883314
26Nucleotide excision repair_Homo sapiens_hsa034201.64615316
27Phototransduction_Homo sapiens_hsa047441.57882339
28B cell receptor signaling pathway_Homo sapiens_hsa046621.54967115
29Selenocompound metabolism_Homo sapiens_hsa004501.54113593
30mRNA surveillance pathway_Homo sapiens_hsa030151.51022148
31Pyrimidine metabolism_Homo sapiens_hsa002401.46730025
32p53 signaling pathway_Homo sapiens_hsa041151.46568538
33Huntingtons disease_Homo sapiens_hsa050161.46451691
34Measles_Homo sapiens_hsa051621.42433331
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.39402184
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38759948
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31744822
38Osteoclast differentiation_Homo sapiens_hsa043801.28158975
39Propanoate metabolism_Homo sapiens_hsa006401.25869322
40T cell receptor signaling pathway_Homo sapiens_hsa046601.25827873
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25762575
42Alzheimers disease_Homo sapiens_hsa050101.24529423
43Long-term potentiation_Homo sapiens_hsa047201.22394760
44Graft-versus-host disease_Homo sapiens_hsa053321.19698307
45Oocyte meiosis_Homo sapiens_hsa041141.19363458
46Hematopoietic cell lineage_Homo sapiens_hsa046401.17592681
47Hepatitis B_Homo sapiens_hsa051611.17148020
48Regulation of autophagy_Homo sapiens_hsa041401.16830549
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15957130
50Shigellosis_Homo sapiens_hsa051311.13779437
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13191698
52Proteasome_Homo sapiens_hsa030501.13018891
53Purine metabolism_Homo sapiens_hsa002301.08152056
54Epstein-Barr virus infection_Homo sapiens_hsa051691.08088316
55Tuberculosis_Homo sapiens_hsa051521.07228662
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.06154711
57Allograft rejection_Homo sapiens_hsa053301.02309582
58Nitrogen metabolism_Homo sapiens_hsa009101.01546784
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01059557
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00683196
61Influenza A_Homo sapiens_hsa051641.00479959
62Butanoate metabolism_Homo sapiens_hsa006501.00289907
63Asthma_Homo sapiens_hsa053100.99393699
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98942897
65Systemic lupus erythematosus_Homo sapiens_hsa053220.96410439
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93297197
67Linoleic acid metabolism_Homo sapiens_hsa005910.92571791
68Platelet activation_Homo sapiens_hsa046110.91169813
69Nicotine addiction_Homo sapiens_hsa050330.89862917
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87708246
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82985267
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82763518
73Chemokine signaling pathway_Homo sapiens_hsa040620.82249311
74Legionellosis_Homo sapiens_hsa051340.81130413
75Pancreatic cancer_Homo sapiens_hsa052120.79626168
76One carbon pool by folate_Homo sapiens_hsa006700.78406630
77Olfactory transduction_Homo sapiens_hsa047400.76335891
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75762832
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75321067
80HTLV-I infection_Homo sapiens_hsa051660.72672903
81Antigen processing and presentation_Homo sapiens_hsa046120.71817394
82Pertussis_Homo sapiens_hsa051330.70683574
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69723778
84Taste transduction_Homo sapiens_hsa047420.69684419
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69260497
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68143448
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68113593
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67680062
89Caffeine metabolism_Homo sapiens_hsa002320.66897157
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65648589
91Colorectal cancer_Homo sapiens_hsa052100.64328778
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64058296
93Tryptophan metabolism_Homo sapiens_hsa003800.63868694
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63670968
95Toxoplasmosis_Homo sapiens_hsa051450.63030483
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.62775876
97TNF signaling pathway_Homo sapiens_hsa046680.59349900
98Ether lipid metabolism_Homo sapiens_hsa005650.57573750
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57424897
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57257466
101African trypanosomiasis_Homo sapiens_hsa051430.56898673
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.56484110
103Circadian entrainment_Homo sapiens_hsa047130.56250732
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56047388
105Autoimmune thyroid disease_Homo sapiens_hsa053200.55582674
106Collecting duct acid secretion_Homo sapiens_hsa049660.55551158
107Thyroid cancer_Homo sapiens_hsa052160.55316314
108Staphylococcus aureus infection_Homo sapiens_hsa051500.53375543
109Amphetamine addiction_Homo sapiens_hsa050310.53066837
110Salmonella infection_Homo sapiens_hsa051320.52311931
111Viral myocarditis_Homo sapiens_hsa054160.51239216
112MicroRNAs in cancer_Homo sapiens_hsa052060.51028398
113Circadian rhythm_Homo sapiens_hsa047100.50392462
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.48350402
115Glutamatergic synapse_Homo sapiens_hsa047240.47087638
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.46705125
117Viral carcinogenesis_Homo sapiens_hsa052030.46518114
118Non-small cell lung cancer_Homo sapiens_hsa052230.46114822
119Chemical carcinogenesis_Homo sapiens_hsa052040.46093228
120Rheumatoid arthritis_Homo sapiens_hsa053230.45934804
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45318450
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45178558
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44079228
124Peroxisome_Homo sapiens_hsa041460.43876927
125Morphine addiction_Homo sapiens_hsa050320.43373506
126VEGF signaling pathway_Homo sapiens_hsa043700.43095155
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41361630
128Cardiac muscle contraction_Homo sapiens_hsa042600.41149511
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40909168
130Hepatitis C_Homo sapiens_hsa051600.40112228
131Calcium signaling pathway_Homo sapiens_hsa040200.39182179
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38900233
133Acute myeloid leukemia_Homo sapiens_hsa052210.36460694
134Long-term depression_Homo sapiens_hsa047300.35681362
135Serotonergic synapse_Homo sapiens_hsa047260.35659337
136Oxytocin signaling pathway_Homo sapiens_hsa049210.35218748
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35011946
138Retinol metabolism_Homo sapiens_hsa008300.34871608
139Malaria_Homo sapiens_hsa051440.34625446
140FoxO signaling pathway_Homo sapiens_hsa040680.34212707
141Apoptosis_Homo sapiens_hsa042100.33973326
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33409036
143Metabolic pathways_Homo sapiens_hsa011000.29752575
144Arachidonic acid metabolism_Homo sapiens_hsa005900.26974213

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