CDC42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.05884162
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84318883
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95686011
4regulation of B cell receptor signaling pathway (GO:0050855)3.74107527
5histamine secretion (GO:0001821)3.70956556
6detection of other organism (GO:0098543)3.70161066
7Arp2/3 complex-mediated actin nucleation (GO:0034314)3.61252571
8regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.54727281
9neutrophil activation (GO:0042119)3.51360082
10antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.48202134
11respiratory burst (GO:0045730)3.40985474
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38335573
13negative regulation of interleukin-12 production (GO:0032695)3.32027766
14granulocyte activation (GO:0036230)3.31037997
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29078676
16neutrophil mediated immunity (GO:0002446)3.28236529
17protein neddylation (GO:0045116)3.26879509
18negative regulation of interleukin-17 production (GO:0032700)3.25696394
19phagosome maturation (GO:0090382)3.24091957
20leukocyte aggregation (GO:0070486)3.22834703
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.18754285
22detection of bacterium (GO:0016045)3.16248037
23production of molecular mediator involved in inflammatory response (GO:0002532)3.13609020
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11952940
25antigen processing and presentation of endogenous antigen (GO:0019883)3.06297439
26protein localization to endosome (GO:0036010)3.05360359
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01000337
28ATP synthesis coupled proton transport (GO:0015986)3.01000337
29positive regulation of monocyte chemotaxis (GO:0090026)2.99985126
30positive regulation by symbiont of host defense response (GO:0052509)2.98061057
31modulation by symbiont of host defense response (GO:0052031)2.98061057
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98061057
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98061057
34positive regulation by organism of defense response of other organism involved in symbiotic interact2.98061057
35modulation by symbiont of host immune response (GO:0052553)2.98061057
36myeloid leukocyte mediated immunity (GO:0002444)2.95960981
37detection of molecule of bacterial origin (GO:0032490)2.94355594
38negative regulation of cell killing (GO:0031342)2.91899421
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91899421
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91784948
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91784948
42detection of external biotic stimulus (GO:0098581)2.89736862
43immunoglobulin mediated immune response (GO:0016064)2.88144901
44signal peptide processing (GO:0006465)2.86986141
45negative regulation of protein autophosphorylation (GO:0031953)2.84506231
46platelet dense granule organization (GO:0060155)2.84146886
47antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83914531
48activated T cell proliferation (GO:0050798)2.83821764
49thrombin receptor signaling pathway (GO:0070493)2.83005358
50activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.82654149
51myeloid cell activation involved in immune response (GO:0002275)2.82072139
52positive regulation of cellular amide metabolic process (GO:0034250)2.81322256
53Rap protein signal transduction (GO:0032486)2.78823790
54mast cell activation (GO:0045576)2.77063448
55actin nucleation (GO:0045010)2.75550673
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.74509349
57response to peptidoglycan (GO:0032494)2.71388597
58sequestering of actin monomers (GO:0042989)2.69600709
59leukocyte degranulation (GO:0043299)2.68613895
60T cell migration (GO:0072678)2.68525998
61interferon-gamma production (GO:0032609)2.68403379
62regulation of tolerance induction (GO:0002643)2.67140488
63myeloid dendritic cell activation (GO:0001773)2.67105528
64regulation of B cell differentiation (GO:0045577)2.66255082
65positive regulation of mast cell activation (GO:0033005)2.62780763
66macrophage activation (GO:0042116)2.61669109
67negative regulation of T cell mediated immunity (GO:0002710)2.60469859
68histamine transport (GO:0051608)2.60407467
69microglial cell activation (GO:0001774)2.60212434
70antigen processing and presentation via MHC class Ib (GO:0002475)2.60080004
71interferon-gamma-mediated signaling pathway (GO:0060333)2.59631727
72regulation of mast cell activation (GO:0033003)2.58607233
73regulation of interferon-beta biosynthetic process (GO:0045357)2.57705360
74positive regulation of leukocyte degranulation (GO:0043302)2.56737922
75leukocyte migration involved in inflammatory response (GO:0002523)2.54647026
76positive regulation of macrophage differentiation (GO:0045651)2.53889389
77myeloid dendritic cell differentiation (GO:0043011)2.53711404
78regulation of monocyte chemotaxis (GO:0090025)2.52464161
79B cell receptor signaling pathway (GO:0050853)2.51160114
80negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.50945337
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50488763
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50154835
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49914038
84* dendritic cell migration (GO:0036336)2.49148620
85eosinophil chemotaxis (GO:0048245)2.49048482
86response to interleukin-15 (GO:0070672)2.49006380
87hepatocyte apoptotic process (GO:0097284)2.48412521
88regulation of MHC class II biosynthetic process (GO:0045346)2.48081590
89positive regulation of antigen processing and presentation (GO:0002579)2.47214035
90cellular response to nerve growth factor stimulus (GO:1990090)2.47204307
91response to nerve growth factor (GO:1990089)2.47204307
92regulation of interleukin-17 production (GO:0032660)2.46888514
93positive regulation of gamma-delta T cell activation (GO:0046645)2.46028184
94positive regulation of interferon-alpha production (GO:0032727)2.45317742
95membrane raft organization (GO:0031579)2.44910216
96oligosaccharide catabolic process (GO:0009313)2.44788481
97regulation of mast cell degranulation (GO:0043304)2.42722665
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42246414
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.42201977
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.41444749
101tolerance induction (GO:0002507)2.41323881
102detection of biotic stimulus (GO:0009595)2.40956837
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40462842
104response to host immune response (GO:0052572)2.40462842
105neutrophil chemotaxis (GO:0030593)2.40064332
106regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40035956
107positive regulation of actin filament polymerization (GO:0030838)2.39962714
108myeloid leukocyte activation (GO:0002274)2.39434554
109transferrin transport (GO:0033572)2.38934553
110ATP hydrolysis coupled proton transport (GO:0015991)2.38550017
111energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.38550017
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38450597
113negative regulation of type 2 immune response (GO:0002829)2.37503092
114leukocyte mediated cytotoxicity (GO:0001909)2.37469967
115positive regulation of glycoprotein metabolic process (GO:1903020)2.37405205
116regulation of T cell migration (GO:2000404)2.37132719
117amino sugar catabolic process (GO:0046348)2.36796945
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35466006
119cellular response to interferon-beta (GO:0035458)2.35329211
120regulation of T cell tolerance induction (GO:0002664)2.35227938
121neutrophil migration (GO:1990266)2.34942266
122negative regulation of microtubule polymerization (GO:0031115)2.34916387
123cellular defense response (GO:0006968)2.34561812
124regulation of cellular amino acid metabolic process (GO:0006521)2.34109503
125regulation of interferon-alpha production (GO:0032647)2.33890986
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.33576700
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.33576700
128regulation of lymphocyte migration (GO:2000401)2.33449047
129regulation of mast cell activation involved in immune response (GO:0033006)2.33345260
130positive regulation of lamellipodium assembly (GO:0010592)2.33170897
131superoxide anion generation (GO:0042554)2.32598188
132response to interferon-beta (GO:0035456)2.32475011
133negative regulation of mast cell activation (GO:0033004)2.32346648
134cellular response to zinc ion (GO:0071294)2.31884898
135positive regulation of T cell migration (GO:2000406)2.30481624
136neural tube formation (GO:0001841)2.30359890
137cellular extravasation (GO:0045123)2.30029438
138positive regulation of tolerance induction (GO:0002645)2.29679918
139positive regulation of chemokine biosynthetic process (GO:0045080)2.29542649
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29380167
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.29293304
142positive regulation of mast cell degranulation (GO:0043306)2.29293304
143positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.28668405
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28649752
145positive regulation of B cell differentiation (GO:0045579)2.28555822
146granulocyte chemotaxis (GO:0071621)2.28544927
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.27937285
148negative regulation of ligase activity (GO:0051352)2.27937285
149positive regulation of regulated secretory pathway (GO:1903307)2.27800402
150positive regulation of T cell chemotaxis (GO:0010820)2.27561995
151regulation of T cell chemotaxis (GO:0010819)2.27561995
152eosinophil migration (GO:0072677)2.27095676
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.26985202
154macrophage activation involved in immune response (GO:0002281)2.26963738
155cellular response to interleukin-15 (GO:0071350)2.26924657
156positive regulation of actin filament depolymerization (GO:0030836)2.26377025
157positive regulation of T-helper 1 type immune response (GO:0002827)2.26258810
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.25992110
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.25992110
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.25992110
161T-helper 1 type immune response (GO:0042088)2.24582048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.45977240
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.38912018
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34473135
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.32337655
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43214017
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21705228
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.08528256
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.98982851
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97010739
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88886374
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75573918
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67866848
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62476358
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62338100
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58063396
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43723499
17* SPI1_23547873_ChIP-Seq_NB4_Human2.42743282
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41828497
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41773054
20* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40575637
21ELK1_19687146_ChIP-ChIP_HELA_Human2.37048356
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20167019
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18006041
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.08485056
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01322721
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00333488
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95398303
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91397902
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90270691
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.89198600
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87473973
32MYB_26560356_Chip-Seq_TH2_Human1.81930248
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81655232
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81246310
35RUNX_20019798_ChIP-Seq_JUKART_Human1.78075771
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.76670669
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63745407
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.56755691
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55337522
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54494487
41* VDR_23849224_ChIP-Seq_CD4+_Human1.54003283
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53817581
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.52313056
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51486556
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47409327
46TAF15_26573619_Chip-Seq_HEK293_Human1.46715304
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46563205
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45331459
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45244876
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.44579768
51GBX2_23144817_ChIP-Seq_PC3_Human1.44323822
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.43973370
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43670334
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43263430
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39545641
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38934506
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38406915
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.36980257
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35401072
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.32431556
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31453927
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30690430
63GATA3_26560356_Chip-Seq_TH2_Human1.28619595
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28304379
65VDR_24763502_ChIP-Seq_THP-1_Human1.25687118
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25623391
67GATA3_27048872_Chip-Seq_THYMUS_Human1.24862505
68P53_22387025_ChIP-Seq_ESCs_Mouse1.24697857
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24477314
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23786426
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.23732340
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23404164
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.22465258
74* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21586725
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.20264102
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19876313
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19860585
78VDR_24787735_ChIP-Seq_THP-1_Human1.18075761
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17363796
80PU_27001747_Chip-Seq_BMDM_Mouse1.17313047
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.16826459
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16419309
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.16274296
84* BRD4_25478319_ChIP-Seq_HGPS_Human1.13657179
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12757717
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11324782
87VDR_22108803_ChIP-Seq_LS180_Human1.11295676
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11139746
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11079024
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11029845
91IGF1R_20145208_ChIP-Seq_DFB_Human1.10687503
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10531231
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.10219596
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09943059
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09835089
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09021233
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09021233
98SMAD4_21799915_ChIP-Seq_A2780_Human1.08095155
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.07796856
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07298383
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.07285948
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07067125
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06584370
104P300_18555785_Chip-Seq_ESCs_Mouse1.06251367
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05986870
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05731134
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04293495
108DCP1A_22483619_ChIP-Seq_HELA_Human1.04285601
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04092241
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03415962
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03118816
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.02014028
113CJUN_26792858_Chip-Seq_BT549_Human1.02008554
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01320753
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00554956
116TRIM28_21343339_ChIP-Seq_HEK293_Human1.00409751
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.00248704
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99715803
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99514381
120EWS_26573619_Chip-Seq_HEK293_Human0.99119582
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99018122
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98988145
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98778914
124* TP63_23658742_ChIP-Seq_EP156T_Human0.98650269
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98331822
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97903286
127TP53_18474530_ChIP-ChIP_U2OS_Human0.97840536
128TFEB_21752829_ChIP-Seq_HELA_Human0.97668701
129CDX2_22108803_ChIP-Seq_LS180_Human0.97324750
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.97098083
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.96682128
132FUS_26573619_Chip-Seq_HEK293_Human0.96597949
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.96504260
134* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96377190
135BCAT_22108803_ChIP-Seq_LS180_Human0.95791808
136SOX2_20726797_ChIP-Seq_SW620_Human0.95528461
137* MYB_26560356_Chip-Seq_TH1_Human0.94388918
138NMYC_18555785_Chip-Seq_ESCs_Mouse0.93667260
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93664787
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92361299
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92322566
142SCL_19346495_ChIP-Seq_HPC-7_Human0.91684503
143* SPI1_23127762_ChIP-Seq_K562_Human0.91220922
144P300_19829295_ChIP-Seq_ESCs_Human0.91133815
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90128133
146SALL4_22934838_ChIP-ChIP_CD34+_Human0.88284163
147ER_23166858_ChIP-Seq_MCF-7_Human0.87500938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05361507
2MP0010234_abnormal_vibrissa_follicle3.50388675
3MP0009785_altered_susceptibility_to3.44053023
4MP0002148_abnormal_hypersensitivity_rea3.36156663
5MP0005671_abnormal_response_to3.23935318
6MP0005000_abnormal_immune_tolerance2.84552679
7MP0003436_decreased_susceptibility_to2.78994963
8MP0002419_abnormal_innate_immunity2.61585496
9MP0006082_CNS_inflammation2.49312784
10MP0005025_abnormal_response_to2.46179547
11MP0003724_increased_susceptibility_to2.45214612
12MP0002452_abnormal_antigen_presenting2.40791523
13MP0001790_abnormal_immune_system2.35023501
14MP0005387_immune_system_phenotype2.35023501
15MP0000685_abnormal_immune_system2.34272845
16MP0002420_abnormal_adaptive_immunity2.27924171
17MP0001819_abnormal_immune_cell2.27602660
18MP0003191_abnormal_cellular_cholesterol2.24001626
19MP0002723_abnormal_immune_serum2.23385246
20MP0001800_abnormal_humoral_immune2.20353453
21MP0003828_pulmonary_edema2.10720270
22MP0003303_peritoneal_inflammation2.01081366
23MP0005248_abnormal_Harderian_gland1.99019530
24MP0006054_spinal_hemorrhage1.94167481
25MP0002006_tumorigenesis1.89501806
26MP0002166_altered_tumor_susceptibility1.86514980
27MP0005058_abnormal_lysosome_morphology1.84721663
28MP0000343_altered_response_to1.79937678
29MP0001533_abnormal_skeleton_physiology1.78053013
30MP0005084_abnormal_gallbladder_morpholo1.76435105
31MP0003448_altered_tumor_morphology1.74997385
32MP0003880_abnormal_central_pattern1.71974519
33MP0009333_abnormal_splenocyte_physiolog1.71903708
34MP0002405_respiratory_system_inflammati1.69331116
35MP0003221_abnormal_cardiomyocyte_apopto1.64720406
36MP0003183_abnormal_peptide_metabolism1.61818934
37MP0000716_abnormal_immune_system1.59900833
38MP0002398_abnormal_bone_marrow1.58264319
39MP0005464_abnormal_platelet_physiology1.51414924
40MP0000465_gastrointestinal_hemorrhage1.50665464
41MP0008438_abnormal_cutaneous_collagen1.45995250
42MP0002877_abnormal_melanocyte_morpholog1.43714582
43MP0001845_abnormal_inflammatory_respons1.41657391
44MP0002933_joint_inflammation1.37382359
45MP0001879_abnormal_lymphatic_vessel1.37349383
46MP0002163_abnormal_gland_morphology1.35173679
47MP0004484_altered_response_of1.34275581
48MP0001905_abnormal_dopamine_level1.31164713
49MP0002102_abnormal_ear_morphology1.30317551
50MP0005310_abnormal_salivary_gland1.30239493
51MP0000858_altered_metastatic_potential1.30130369
52MP0000372_irregular_coat_pigmentation1.29281423
53MP0002429_abnormal_blood_cell1.27770831
54MP0001853_heart_inflammation1.27747897
55MP0003763_abnormal_thymus_physiology1.25040124
56MP0005164_abnormal_response_to1.24846205
57MP0003172_abnormal_lysosome_physiology1.24144307
58MP0001542_abnormal_bone_strength1.22956745
59MP0000604_amyloidosis1.20585929
60MP0004510_myositis1.19704228
61MP0004883_abnormal_blood_vessel1.19359272
62MP0000920_abnormal_myelination1.19312323
63MP0001529_abnormal_vocalization1.19109683
64MP0000689_abnormal_spleen_morphology1.18898826
65MP0002722_abnormal_immune_system1.17928214
66MP0001851_eye_inflammation1.16967987
67MP0000015_abnormal_ear_pigmentation1.15699818
68MP0010678_abnormal_skin_adnexa1.14097003
69MP0010352_gastrointestinal_tract_polyps1.14055395
70MP0010155_abnormal_intestine_physiology1.11688121
71MP0010386_abnormal_urinary_bladder1.06644675
72MP0005174_abnormal_tail_pigmentation1.05632156
73MP0002009_preneoplasia1.03700557
74MP0003195_calcinosis1.02784322
75MP0001958_emphysema1.02239505
76MP0004947_skin_inflammation1.01045536
77MP0002909_abnormal_adrenal_gland1.00191233
78MP0005166_decreased_susceptibility_to0.98414063
79MP0002998_abnormal_bone_remodeling0.98005491
80MP0003866_abnormal_defecation0.96517025
81MP0000569_abnormal_digit_pigmentation0.95441048
82MP0008260_abnormal_autophagy0.95091621
83MP0002928_abnormal_bile_duct0.94500548
84MP0008469_abnormal_protein_level0.93562462
85MP0005167_abnormal_blood-brain_barrier0.91539371
86MP0001873_stomach_inflammation0.90257973
87MP0009379_abnormal_foot_pigmentation0.90091501
88MP0005390_skeleton_phenotype0.87975212
89MP0005171_absent_coat_pigmentation0.87782449
90MP0003300_gastrointestinal_ulcer0.86009509
91MP0002277_abnormal_respiratory_mucosa0.85856408
92MP0001915_intracranial_hemorrhage0.84135463
93MP0002736_abnormal_nociception_after0.84046277
94MP0002332_abnormal_exercise_endurance0.82724581
95MP0000249_abnormal_blood_vessel0.79687350
96MP0009840_abnormal_foam_cell0.79535775
97MP0005165_increased_susceptibility_to0.79376707
98MP0009763_increased_sensitivity_to0.78516168
99MP0003566_abnormal_cell_adhesion0.77527672
100MP0002396_abnormal_hematopoietic_system0.77136564
101MP0000703_abnormal_thymus_morphology0.76821721
102MP0004272_abnormal_basement_membrane0.76410670
103MP0001968_abnormal_touch/_nociception0.76165482
104MP0003075_altered_response_to0.75850227
105MP0000681_abnormal_thyroid_gland0.75673041
106MP0002090_abnormal_vision0.75412805
107MP0000516_abnormal_urinary_system0.75298426
108MP0005367_renal/urinary_system_phenotyp0.75298426
109MP0009764_decreased_sensitivity_to0.71487883
110MP0002693_abnormal_pancreas_physiology0.71470291
111MP0004808_abnormal_hematopoietic_stem0.70691565
112MP0006276_abnormal_autonomic_nervous0.70239869
113MP0005379_endocrine/exocrine_gland_phen0.70202338
114MP0003091_abnormal_cell_migration0.69437112
115MP0003279_aneurysm0.68904233
116MP0002295_abnormal_pulmonary_circulatio0.68621172
117MP0002095_abnormal_skin_pigmentation0.67144227
118MP0005397_hematopoietic_system_phenotyp0.66942810
119MP0001545_abnormal_hematopoietic_system0.66942810
120MP0000647_abnormal_sebaceous_gland0.66855809
121MP0002168_other_aberrant_phenotype0.66540529
122MP0004782_abnormal_surfactant_physiolog0.66314214
123MP0003329_amyloid_beta_deposits0.65691074
124MP0000427_abnormal_hair_cycle0.65152770
125MP0003795_abnormal_bone_structure0.65007306
126MP0000490_abnormal_crypts_of0.64388087
127MP0003656_abnormal_erythrocyte_physiolo0.63390969
128MP0008004_abnormal_stomach_pH0.62905651
129MP0003690_abnormal_glial_cell0.62724707
130MP0003045_fibrosis0.61941224
131MP0009765_abnormal_xenobiotic_induced0.57300596

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.37461574
2Elevated erythrocyte sedimentation rate (HP:0003565)4.47116954
3Recurrent bacterial skin infections (HP:0005406)4.46003861
4Eczematoid dermatitis (HP:0000976)4.32126590
5Myositis (HP:0100614)3.95108872
6Abnormality of macrophages (HP:0004311)3.92806082
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.41483767
8Increased cerebral lipofuscin (HP:0011813)3.35346033
9Vacuolated lymphocytes (HP:0001922)3.28255214
10Mediastinal lymphadenopathy (HP:0100721)3.21523258
11Optic neuritis (HP:0100653)3.21468549
12Retrobulbar optic neuritis (HP:0100654)3.21468549
13Orchitis (HP:0100796)3.12646104
14Obstructive lung disease (HP:0006536)3.11284163
15Chronic obstructive pulmonary disease (HP:0006510)3.11284163
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95778724
17Disinhibition (HP:0000734)2.95626340
18Acute necrotizing encephalopathy (HP:0006965)2.90122438
19T lymphocytopenia (HP:0005403)2.89151295
20IgM deficiency (HP:0002850)2.88897325
21Abnormality of T cell number (HP:0011839)2.86072529
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.84264822
23Myocardial infarction (HP:0001658)2.75989300
24Tetraparesis (HP:0002273)2.75495674
25Subacute progressive viral hepatitis (HP:0006572)2.70721580
26Recurrent skin infections (HP:0001581)2.68805526
27Chronic otitis media (HP:0000389)2.67013125
28Progressive macrocephaly (HP:0004481)2.63980978
29Diminished motivation (HP:0000745)2.63950870
30Parakeratosis (HP:0001036)2.63788589
31Abnormal mitochondria in muscle tissue (HP:0008316)2.63015017
32Recurrent gram-negative bacterial infections (HP:0005420)2.58836299
33Urticaria (HP:0001025)2.58821694
34Mitochondrial inheritance (HP:0001427)2.57844759
35Amyotrophic lateral sclerosis (HP:0007354)2.57183750
36Mutism (HP:0002300)2.57165320
37Heterochromia iridis (HP:0001100)2.52938027
38Interstitial pulmonary disease (HP:0006530)2.50627371
39Recurrent fungal infections (HP:0002841)2.47853215
40Stomatitis (HP:0010280)2.47686254
41Episodic fever (HP:0001954)2.46556089
42Pheochromocytoma (HP:0002666)2.45198906
43Spontaneous hematomas (HP:0007420)2.44236646
44Exertional dyspnea (HP:0002875)2.43972232
45Chronic diarrhea (HP:0002028)2.42376761
46Apathy (HP:0000741)2.41045283
47Thyroid carcinoma (HP:0002890)2.39788143
48Papillary thyroid carcinoma (HP:0002895)2.39429573
49Vasculitis (HP:0002633)2.39052115
50Petechiae (HP:0000967)2.38306425
51Increased hepatocellular lipid droplets (HP:0006565)2.37152966
52Increased CSF protein (HP:0002922)2.33502385
53Arterial tortuosity (HP:0005116)2.32537561
54Limb dystonia (HP:0002451)2.31094633
55Abnormality of glycolipid metabolism (HP:0010969)2.31033105
56Abnormality of liposaccharide metabolism (HP:0010968)2.31033105
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.31033105
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29949646
59Prolonged bleeding time (HP:0003010)2.29612917
60Recurrent viral infections (HP:0004429)2.29429848
61Cerebral hemorrhage (HP:0001342)2.28672741
62Gingival bleeding (HP:0000225)2.28376896
63Hypothermia (HP:0002045)2.25958833
64Meningitis (HP:0001287)2.25872868
65Chest pain (HP:0100749)2.24918804
66Hypergammaglobulinemia (HP:0010702)2.24268115
67Increased IgM level (HP:0003496)2.23766353
68Hepatosplenomegaly (HP:0001433)2.23704968
69Papilledema (HP:0001085)2.22564156
70Hematochezia (HP:0002573)2.22143956
71Polyphagia (HP:0002591)2.21771865
72Increased serum pyruvate (HP:0003542)2.21428961
73Abnormality of glycolysis (HP:0004366)2.21428961
74Curly hair (HP:0002212)2.21157325
75Recurrent bronchitis (HP:0002837)2.17646720
76Vascular tortuosity (HP:0004948)2.16688580
77Agnosia (HP:0010524)2.15779331
78Recurrent pneumonia (HP:0006532)2.15380296
79Cellulitis (HP:0100658)2.13772681
80Orthostatic hypotension (HP:0001278)2.13064141
81Neuroendocrine neoplasm (HP:0100634)2.12877694
82Thrombocytosis (HP:0001894)2.11628485
83Pulmonary infiltrates (HP:0002113)2.09402651
84IgG deficiency (HP:0004315)2.08855879
85Leukocytosis (HP:0001974)2.08086723
86Transitional cell carcinoma of the bladder (HP:0006740)2.06080570
87Poor head control (HP:0002421)2.05214814
88Abnormal platelet volume (HP:0011876)2.05008226
89Joint swelling (HP:0001386)2.02826152
90Amyloidosis (HP:0011034)2.02704743
91Bladder carcinoma (HP:0002862)2.01717306
92Bladder neoplasm (HP:0009725)2.01717306
93Muscle fibrillation (HP:0010546)2.01631772
94Osteomyelitis (HP:0002754)2.00178842
95Conjunctival hamartoma (HP:0100780)1.97880915
96Mucosal telangiectasiae (HP:0100579)1.96942229
97Hip dysplasia (HP:0001385)1.96653533
98Dysostosis multiplex (HP:0000943)1.96307928
99Progressive neurologic deterioration (HP:0002344)1.95638882
100Systemic lupus erythematosus (HP:0002725)1.95312590
101Thyroiditis (HP:0100646)1.95243245
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95200443
103Agitation (HP:0000713)1.94861024
104Gastrointestinal stroma tumor (HP:0100723)1.94528262
105Gastrointestinal infarctions (HP:0005244)1.93053228
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.91185258
107Encephalitis (HP:0002383)1.91119301
108Inappropriate behavior (HP:0000719)1.90916552
109Keratoconjunctivitis sicca (HP:0001097)1.90776737
110Xerostomia (HP:0000217)1.90445629
111Basal ganglia calcification (HP:0002135)1.88729717
112Gingivitis (HP:0000230)1.88148483
113Vertebral compression fractures (HP:0002953)1.87637350
114Autoimmune thrombocytopenia (HP:0001973)1.87587501
115Increased CSF lactate (HP:0002490)1.87440398
116Micronodular cirrhosis (HP:0001413)1.86779378
117Renal Fanconi syndrome (HP:0001994)1.86239636
118Glomerulopathy (HP:0100820)1.85407004
119Arterial thrombosis (HP:0004420)1.85389898
120Abnormality of binocular vision (HP:0011514)1.84640706
121Diplopia (HP:0000651)1.84640706
122Hepatocellular necrosis (HP:0001404)1.84374928
123Epistaxis (HP:0000421)1.83053218
124Recurrent lower respiratory tract infections (HP:0002783)1.82722159
125Lipid accumulation in hepatocytes (HP:0006561)1.82628449
126Increased mean platelet volume (HP:0011877)1.82446163
127Insidious onset (HP:0003587)1.79457736
128Termporal pattern (HP:0011008)1.79457736
129Recurrent cutaneous fungal infections (HP:0011370)1.78785216
130Chronic mucocutaneous candidiasis (HP:0002728)1.78785216
131Abnormality of T cells (HP:0002843)1.78249200
132Pustule (HP:0200039)1.78222549
133Periodontitis (HP:0000704)1.78082187
134Congenital ichthyosiform erythroderma (HP:0007431)1.77799782
135Pulmonary embolism (HP:0002204)1.77552402
136Loss of speech (HP:0002371)1.77243580
137Autoimmune hemolytic anemia (HP:0001890)1.76678276
138Hemoptysis (HP:0002105)1.76375215
139Chronic sinusitis (HP:0011109)1.74866596
140Tongue fasciculations (HP:0001308)1.74725276
141Neoplasm of the peripheral nervous system (HP:0100007)1.74555847
142Amaurosis fugax (HP:0100576)1.74398997
143Abnormality of the musculature of the pelvis (HP:0001469)1.73283757
144Abnormality of the hip-girdle musculature (HP:0001445)1.73283757
145Fatigue (HP:0012378)1.73238632
146Albinism (HP:0001022)1.72589336
147Purpura (HP:0000979)1.72480951
148Keratoconjunctivitis (HP:0001096)1.71792825
149Cortical dysplasia (HP:0002539)1.71279051
150Abnormality of eosinophils (HP:0001879)1.69637595
151Abnormal hair whorl (HP:0010721)1.68942402
152Eosinophilia (HP:0001880)1.68551544
153Lymphopenia (HP:0001888)1.68306982
154Acute encephalopathy (HP:0006846)1.66327117
155Abnormality of the lumbar spine (HP:0100712)1.66239012
156Abnormality of the vocal cords (HP:0008777)1.65587970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.46655917
2TRIM283.86031879
3MST43.15348535
4RIPK42.67556208
5LIMK12.32810998
6BLK2.32667247
7IRAK42.20969193
8PIM22.06548710
9PBK1.97452570
10TESK21.95475760
11KIT1.93943041
12TXK1.91045425
13MAP4K11.82264192
14MAP3K141.82184502
15TBK11.81225554
16STK241.80985806
17ERBB31.80450803
18KSR11.77520578
19TESK11.75965113
20KDR1.69349394
21BCR1.67151919
22TGFBR21.61224494
23BMPR1B1.59896648
24ZAP701.58964097
25FER1.57506237
26JAK31.54251242
27PLK21.53943385
28GRK71.51046444
29SYK1.50007525
30TGFBR11.49345975
31FGR1.46462918
32TYK21.46073977
33FES1.42080988
34ARAF1.41086388
35TEC1.37870004
36MAP3K61.35039756
37MAP3K41.34775655
38CDK191.33767756
39NME21.30986232
40MYLK1.30813542
41SCYL21.29282670
42MAP3K21.26415863
43CSF1R1.25136093
44LRRK21.24949583
45ITK1.18578112
46BTK1.17818247
47BUB11.17533607
48SIK31.15006228
49LCK1.14107797
50BMPR21.10214676
51WNK31.08444099
52TSSK61.08110850
53PAK41.08064285
54EPHB11.06699727
55STK161.06086946
56EIF2AK11.01788660
57EPHA30.99805658
58CAMKK20.99448904
59CDK60.99116652
60LYN0.98654102
61EIF2AK30.98279420
62MAP3K50.97413686
63GRK60.97190189
64CSNK1G10.95074341
65PAK30.91852017
66DAPK10.90786912
67ADRBK20.89435822
68IKBKB0.87772419
69STK100.87320899
70DYRK20.86346471
71ACVR1B0.86106583
72MINK10.85847718
73JAK20.83111995
74ILK0.82855766
75MAP2K40.80873076
76MAPKAPK50.80096509
77IKBKE0.78350738
78CASK0.74971959
79CSNK1G30.74434134
80FGFR30.73825268
81HCK0.71587833
82TAOK30.69226766
83CLK10.67051564
84MAP3K10.66878337
85VRK10.66471738
86JAK10.66451701
87RPS6KA40.65353474
88CSK0.64891906
89MAP4K20.63669384
90YES10.62747157
91TNIK0.62115409
92GRK50.61820166
93MAP2K70.60713548
94NME10.60156268
95MOS0.59072171
96MAPK130.58981246
97ABL10.58781467
98FRK0.57716790
99PRKCD0.57581294
100MARK10.57358013
101CDK140.56660661
102MAP3K30.55505748
103PTK2B0.55092635
104MKNK20.53786446
105NEK90.53127686
106ABL20.52989648
107MAP3K130.52629441
108ROCK20.51183940
109CCNB10.51071503
110FYN0.48794762
111TRPM70.46442426
112MAPKAPK20.46306168
113MAP2K30.46190129
114ADRBK10.45382258
115EGFR0.45005019
116MATK0.43882400
117CSNK1G20.43364406
118TIE10.41259572
119CSNK1A1L0.41047194
120DAPK30.40252239
121OXSR10.40016994
122PRKCQ0.40005175
123INSR0.39938852
124PRKCE0.39589871
125STK38L0.38391664
126STK390.37881031
127IGF1R0.36807830
128IRAK10.32017546

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.06887474
2Graft-versus-host disease_Homo sapiens_hsa053322.31211636
3Rheumatoid arthritis_Homo sapiens_hsa053232.17879111
4Oxidative phosphorylation_Homo sapiens_hsa001902.13121082
5Leishmaniasis_Homo sapiens_hsa051402.05102360
6Phagosome_Homo sapiens_hsa041452.00660135
7* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.97974628
8Collecting duct acid secretion_Homo sapiens_hsa049661.89060915
9Protein export_Homo sapiens_hsa030601.84730927
10Vibrio cholerae infection_Homo sapiens_hsa051101.76789159
11Parkinsons disease_Homo sapiens_hsa050121.72925765
12Pertussis_Homo sapiens_hsa051331.71604169
13Allograft rejection_Homo sapiens_hsa053301.67343974
14Antigen processing and presentation_Homo sapiens_hsa046121.64743137
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60982294
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60881814
17Legionellosis_Homo sapiens_hsa051341.58727174
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53676658
19* Shigellosis_Homo sapiens_hsa051311.48719380
20Osteoclast differentiation_Homo sapiens_hsa043801.47611722
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47519377
22Tuberculosis_Homo sapiens_hsa051521.45833063
23Sulfur metabolism_Homo sapiens_hsa009201.42920892
24Lysosome_Homo sapiens_hsa041421.42732841
25Ribosome_Homo sapiens_hsa030101.42153063
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41755636
27Alzheimers disease_Homo sapiens_hsa050101.40720000
28* Salmonella infection_Homo sapiens_hsa051321.38883657
29Malaria_Homo sapiens_hsa051441.36397840
30* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33001318
31Type I diabetes mellitus_Homo sapiens_hsa049401.28207049
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23829118
33Measles_Homo sapiens_hsa051621.23707273
34Viral myocarditis_Homo sapiens_hsa054161.22927234
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20505423
36Primary immunodeficiency_Homo sapiens_hsa053401.20319900
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20100000
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.17088598
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.16647179
40Hematopoietic cell lineage_Homo sapiens_hsa046401.12466604
41B cell receptor signaling pathway_Homo sapiens_hsa046621.11724345
42* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08066346
43Regulation of autophagy_Homo sapiens_hsa041401.07078463
44Autoimmune thyroid disease_Homo sapiens_hsa053201.06597150
45* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04047015
46Asthma_Homo sapiens_hsa053101.02665353
47* Chemokine signaling pathway_Homo sapiens_hsa040621.02352470
48Huntingtons disease_Homo sapiens_hsa050161.00742614
49Toxoplasmosis_Homo sapiens_hsa051451.00115953
50* Leukocyte transendothelial migration_Homo sapiens_hsa046700.99399945
51Epstein-Barr virus infection_Homo sapiens_hsa051690.98649195
52African trypanosomiasis_Homo sapiens_hsa051430.95969443
53* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95167180
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95075724
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94938046
56RNA polymerase_Homo sapiens_hsa030200.92278548
57Synaptic vesicle cycle_Homo sapiens_hsa047210.91346617
58* T cell receptor signaling pathway_Homo sapiens_hsa046600.87549235
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85477156
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83657013
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83180101
62Apoptosis_Homo sapiens_hsa042100.83029711
63Other glycan degradation_Homo sapiens_hsa005110.82558353
64TNF signaling pathway_Homo sapiens_hsa046680.81386646
65Influenza A_Homo sapiens_hsa051640.80622628
66Platelet activation_Homo sapiens_hsa046110.79759028
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79130733
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.79113774
69Hepatitis B_Homo sapiens_hsa051610.78025317
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74529208
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73252954
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.68323604
73* Endocytosis_Homo sapiens_hsa041440.68183707
74Herpes simplex infection_Homo sapiens_hsa051680.67375973
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65443818
76Sphingolipid metabolism_Homo sapiens_hsa006000.63388212
77* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62583938
78Prolactin signaling pathway_Homo sapiens_hsa049170.61109861
79Endometrial cancer_Homo sapiens_hsa052130.59000379
80Serotonergic synapse_Homo sapiens_hsa047260.58781109
81Colorectal cancer_Homo sapiens_hsa052100.58116279
82Steroid biosynthesis_Homo sapiens_hsa001000.57691017
83Renin-angiotensin system_Homo sapiens_hsa046140.56929753
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55790766
85Hepatitis C_Homo sapiens_hsa051600.55774375
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55420019
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54945929
88Fatty acid elongation_Homo sapiens_hsa000620.54658967
89N-Glycan biosynthesis_Homo sapiens_hsa005100.54578921
90Dorso-ventral axis formation_Homo sapiens_hsa043200.50167194
91HIF-1 signaling pathway_Homo sapiens_hsa040660.50164108
92Staphylococcus aureus infection_Homo sapiens_hsa051500.49658208
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48632501
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.48289672
95Renin secretion_Homo sapiens_hsa049240.47205017
96Amoebiasis_Homo sapiens_hsa051460.47162001
97* Ras signaling pathway_Homo sapiens_hsa040140.46802949
98* Pancreatic cancer_Homo sapiens_hsa052120.45781737
99* Neurotrophin signaling pathway_Homo sapiens_hsa047220.44743261
100Long-term depression_Homo sapiens_hsa047300.43502726
101* Viral carcinogenesis_Homo sapiens_hsa052030.43009041
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42138222
103Dopaminergic synapse_Homo sapiens_hsa047280.40842636
104* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40598201
105Spliceosome_Homo sapiens_hsa030400.39249023
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36777542
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36231440
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35330888
109Morphine addiction_Homo sapiens_hsa050320.35168958
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34453491
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34239350
112Long-term potentiation_Homo sapiens_hsa047200.33707633
113* Rap1 signaling pathway_Homo sapiens_hsa040150.32566442
114GABAergic synapse_Homo sapiens_hsa047270.32308480
115Nicotine addiction_Homo sapiens_hsa050330.32261201
116Inositol phosphate metabolism_Homo sapiens_hsa005620.31398404
117* Renal cell carcinoma_Homo sapiens_hsa052110.31001002
118Alcoholism_Homo sapiens_hsa050340.30175886
119* Proteoglycans in cancer_Homo sapiens_hsa052050.29410977
120Basal transcription factors_Homo sapiens_hsa030220.28818642

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »