CDC42BPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.14319512
2locomotory exploration behavior (GO:0035641)4.98698000
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91548112
4vocalization behavior (GO:0071625)4.84565668
5synaptic vesicle maturation (GO:0016188)4.82723253
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.54050057
7glutamate secretion (GO:0014047)4.50622928
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43365354
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37923048
10synaptic vesicle exocytosis (GO:0016079)4.29559798
11regulation of synaptic vesicle exocytosis (GO:2000300)4.20947175
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.14709933
13regulation of glutamate receptor signaling pathway (GO:1900449)4.10104391
14neuronal action potential propagation (GO:0019227)3.96584746
15neurotransmitter-gated ion channel clustering (GO:0072578)3.95081200
16protein localization to synapse (GO:0035418)3.94068898
17glutamate receptor signaling pathway (GO:0007215)3.83549965
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83162482
19synaptic transmission, glutamatergic (GO:0035249)3.82763649
20neuron cell-cell adhesion (GO:0007158)3.82646587
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76552519
22regulation of synaptic vesicle transport (GO:1902803)3.70738010
23neurotransmitter secretion (GO:0007269)3.70433755
24regulation of neuronal synaptic plasticity (GO:0048168)3.69654219
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66545710
26exploration behavior (GO:0035640)3.64860001
27neuron-neuron synaptic transmission (GO:0007270)3.62370157
28gamma-aminobutyric acid transport (GO:0015812)3.59805475
29cerebellar granule cell differentiation (GO:0021707)3.51022878
30cerebellar Purkinje cell differentiation (GO:0021702)3.50908507
31dendritic spine morphogenesis (GO:0060997)3.43281699
32presynaptic membrane assembly (GO:0097105)3.38193180
33cellular potassium ion homeostasis (GO:0030007)3.37541220
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36268453
35long-term memory (GO:0007616)3.35551675
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33523577
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32472551
38regulation of synapse structural plasticity (GO:0051823)3.27719258
39layer formation in cerebral cortex (GO:0021819)3.26303077
40postsynaptic membrane organization (GO:0001941)3.23623743
41positive regulation of membrane potential (GO:0045838)3.23082100
42regulation of postsynaptic membrane potential (GO:0060078)3.22229463
43transmission of nerve impulse (GO:0019226)3.19890415
44presynaptic membrane organization (GO:0097090)3.18490951
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.17289055
46auditory behavior (GO:0031223)3.15445216
47dendrite morphogenesis (GO:0048813)3.14960145
48positive regulation of protein autophosphorylation (GO:0031954)3.12854985
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.12402241
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12379009
51long-term synaptic potentiation (GO:0060291)3.12014600
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08189979
53regulation of dendritic spine morphogenesis (GO:0061001)3.07024185
54neuron recognition (GO:0008038)3.05419740
55regulation of synaptic plasticity (GO:0048167)3.04730548
56positive regulation of synapse maturation (GO:0090129)3.03478677
57synaptic vesicle endocytosis (GO:0048488)3.01462581
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.01256067
59membrane depolarization during action potential (GO:0086010)3.00512247
60regulation of neurotransmitter secretion (GO:0046928)3.00375750
61neurotransmitter transport (GO:0006836)3.00207056
62proline transport (GO:0015824)2.99344362
63neuromuscular process controlling balance (GO:0050885)2.98289359
64axonal fasciculation (GO:0007413)2.98025386
65activation of protein kinase A activity (GO:0034199)2.98016097
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97288901
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96790145
68glycine transport (GO:0015816)2.88674313
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86817750
70positive regulation of cardiac muscle hypertrophy (GO:0010613)2.86627171
71positive regulation of muscle hypertrophy (GO:0014742)2.86627171
72response to auditory stimulus (GO:0010996)2.83204257
73membrane depolarization (GO:0051899)2.83075644
74innervation (GO:0060384)2.82315984
75membrane hyperpolarization (GO:0060081)2.80850057
76mechanosensory behavior (GO:0007638)2.80050953
77regulation of vesicle fusion (GO:0031338)2.78388758
78neuronal ion channel clustering (GO:0045161)2.78199644
79regulation of neurotransmitter transport (GO:0051588)2.78013614
80cell communication by electrical coupling (GO:0010644)2.77952657
81positive regulation of glycolytic process (GO:0045821)2.77308064
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76571488
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76373239
84synapse assembly (GO:0007416)2.75688141
85L-amino acid import (GO:0043092)2.75361849
86sodium ion export (GO:0071436)2.73708500
87dendritic spine organization (GO:0097061)2.72759684
88regulation of neurotransmitter levels (GO:0001505)2.72437361
89cell differentiation in hindbrain (GO:0021533)2.69007165
90vesicle transport along microtubule (GO:0047496)2.68619544
91learning (GO:0007612)2.68026249
92regulation of voltage-gated calcium channel activity (GO:1901385)2.67973335
93neuromuscular process (GO:0050905)2.67034960
94positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66998458
95regulation of hexokinase activity (GO:1903299)2.62886638
96regulation of glucokinase activity (GO:0033131)2.62886638
97startle response (GO:0001964)2.62876873
98negative regulation of dendrite development (GO:2000171)2.61463216
99synapse organization (GO:0050808)2.61208540
100regulation of synapse maturation (GO:0090128)2.60610668
101positive regulation of synaptic transmission (GO:0050806)2.60578017
102regulation of Rac protein signal transduction (GO:0035020)2.60473160
103regulation of dendritic spine development (GO:0060998)2.59613790
104adult walking behavior (GO:0007628)2.59180138
105synaptic transmission (GO:0007268)2.59046852
106neuromuscular process controlling posture (GO:0050884)2.58587323
107regulation of synaptic transmission (GO:0050804)2.57410399
108lactate metabolic process (GO:0006089)2.55800556
109prepulse inhibition (GO:0060134)2.54956506
110negative regulation of dendrite morphogenesis (GO:0050774)2.53893317
111regulation of type B pancreatic cell apoptotic process (GO:2000674)2.53787965
112potassium ion import (GO:0010107)2.52527712
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48223784
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.45121148
115atrial cardiac muscle cell action potential (GO:0086014)2.43445983
116regulation of axon extension involved in axon guidance (GO:0048841)2.34451780
117Golgi to endosome transport (GO:0006895)2.31380781
118detection of calcium ion (GO:0005513)2.30196150
119mitotic sister chromatid cohesion (GO:0007064)2.24145088
120response to pheromone (GO:0019236)2.22819799
121negative regulation of hormone biosynthetic process (GO:0032353)2.19491787
122cerebral cortex radially oriented cell migration (GO:0021799)2.19106831
123regulation of protein glycosylation (GO:0060049)2.18395892
124establishment of protein localization to Golgi (GO:0072600)2.17268226
125myelination in peripheral nervous system (GO:0022011)2.15263391
126peripheral nervous system axon ensheathment (GO:0032292)2.15263391
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.11976309
128vascular smooth muscle contraction (GO:0014829)2.11467061
129C4-dicarboxylate transport (GO:0015740)2.10566871
130behavioral response to ethanol (GO:0048149)2.10212079
131insulin secretion (GO:0030073)2.09806041
132positive regulation of actin filament depolymerization (GO:0030836)2.08869166
133protein targeting to Golgi (GO:0000042)2.07920590
134zinc ion transport (GO:0006829)2.06592961
135chemosensory behavior (GO:0007635)2.06298136
136regulation of axon guidance (GO:1902667)2.06143314
137limb bud formation (GO:0060174)2.04939508
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.04907769
139regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.03996364
140astrocyte development (GO:0014002)2.03502560
141chondrocyte proliferation (GO:0035988)2.03397550
142righting reflex (GO:0060013)2.03391771
143regulation of cell communication by electrical coupling (GO:0010649)2.02027819
144positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.00441539
145negative regulation of axon guidance (GO:1902668)1.99431816
146brain morphogenesis (GO:0048854)1.98962622
147positive regulation of macroautophagy (GO:0016239)1.98951812
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.97954813
149prenylation (GO:0097354)1.97275085
150protein prenylation (GO:0018342)1.97275085
151regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.96893195
152embryonic retina morphogenesis in camera-type eye (GO:0060059)1.95817487
153positive regulation of mitotic metaphase/anaphase transition (GO:0045842)1.94472799
154positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)1.94472799
155positive regulation of mitotic sister chromatid separation (GO:1901970)1.94472799
156lymphangiogenesis (GO:0001946)1.94324953
157retrograde transport, vesicle recycling within Golgi (GO:0000301)1.93529384
158protein localization to endosome (GO:0036010)1.93375411
159negative regulation of activin receptor signaling pathway (GO:0032926)1.89212344
160regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.89178485
161regulation of cardiac muscle hypertrophy (GO:0010611)1.88280076
162COPII vesicle coating (GO:0048208)1.86911298
163negative regulation of hormone metabolic process (GO:0032351)1.85685732
164inositol phosphate catabolic process (GO:0071545)1.85657343
165regulation of muscle hypertrophy (GO:0014743)1.83810954
166regulation of muscle adaptation (GO:0043502)1.83498117
167regulation of heart rate by cardiac conduction (GO:0086091)1.83362263
168intraciliary transport (GO:0042073)1.83113635
169regulation of keratinocyte proliferation (GO:0010837)1.82440912
170regulation of integrin-mediated signaling pathway (GO:2001044)1.82392361
171auditory receptor cell differentiation (GO:0042491)1.82037552
172interkinetic nuclear migration (GO:0022027)1.81960515
173dorsal/ventral axis specification (GO:0009950)1.81502672
174cardiac conduction (GO:0061337)1.81321545
175UDP-N-acetylglucosamine metabolic process (GO:0006047)1.81287174
176inositol phosphate-mediated signaling (GO:0048016)1.79928740
177apical protein localization (GO:0045176)1.79764707
178central nervous system neuron axonogenesis (GO:0021955)1.78993754
179collagen fibril organization (GO:0030199)1.78953057
180positive regulation of cardiac muscle cell differentiation (GO:2000727)1.78195826
181regulation of protein autophosphorylation (GO:0031952)1.78071835
182pancreas development (GO:0031016)1.77525581
183positive regulation of meiosis (GO:0045836)1.77478336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61314357
2GBX2_23144817_ChIP-Seq_PC3_Human3.84802459
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.10453235
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82347159
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79027437
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78323124
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61720112
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46776468
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46776468
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35796798
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29407530
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28220037
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27837392
14DROSHA_22980978_ChIP-Seq_HELA_Human2.26848246
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25870197
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.22870653
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22146964
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.19640083
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16569546
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13765455
21AR_21572438_ChIP-Seq_LNCaP_Human2.04022894
22REST_21632747_ChIP-Seq_MESCs_Mouse2.02856122
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98482979
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.97494831
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.91990588
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.91725751
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91156973
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86586480
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83339343
30SMAD4_21799915_ChIP-Seq_A2780_Human1.82911500
31VDR_22108803_ChIP-Seq_LS180_Human1.72864365
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71243257
33* EWS_26573619_Chip-Seq_HEK293_Human1.69205327
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65612731
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.59239078
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58713017
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56680047
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53877420
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.53877011
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.52721793
41P300_19829295_ChIP-Seq_ESCs_Human1.52385896
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52246364
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.51392834
44TAF15_26573619_Chip-Seq_HEK293_Human1.50271029
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49925988
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49386036
47* STAT3_23295773_ChIP-Seq_U87_Human1.48200017
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43358877
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.42536251
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42297325
51* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40847585
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40011101
53BCAT_22108803_ChIP-Seq_LS180_Human1.36858942
54* EZH2_27294783_Chip-Seq_NPCs_Mouse1.36543729
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36215120
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35770947
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35682534
58* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35157308
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.34744095
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34235939
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33539902
62CBP_20019798_ChIP-Seq_JUKART_Human1.33539902
63TP53_16413492_ChIP-PET_HCT116_Human1.33307900
64* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33233792
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.32824780
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29780767
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29629424
68AR_25329375_ChIP-Seq_VCAP_Human1.29535057
69AHR_22903824_ChIP-Seq_MCF-7_Human1.29245890
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29137626
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29083704
72ZNF274_21170338_ChIP-Seq_K562_Hela1.28467269
73* P53_22387025_ChIP-Seq_ESCs_Mouse1.28365866
74* CJUN_26792858_Chip-Seq_BT549_Human1.28137126
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27298017
76* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27255125
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27132832
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27129960
79* AR_19668381_ChIP-Seq_PC3_Human1.26787900
80* TCF4_23295773_ChIP-Seq_U87_Human1.25711490
81* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24464632
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.24297688
83BRD4_25478319_ChIP-Seq_HGPS_Human1.23824656
84IGF1R_20145208_ChIP-Seq_DFB_Human1.21794340
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21111472
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20641239
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20605074
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20473601
89* CMYC_18555785_Chip-Seq_ESCs_Mouse1.19948577
90* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17378070
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16074200
92* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15771461
93* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15156270
94* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15117812
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14982425
96TCF4_22108803_ChIP-Seq_LS180_Human1.13371907
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13068654
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12952070
99* CDX2_22108803_ChIP-Seq_LS180_Human1.12640029
100TP53_18474530_ChIP-ChIP_U2OS_Human1.11690548
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10923122
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10579464
103* NFE2_27457419_Chip-Seq_LIVER_Mouse1.10414990
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.10092309
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.09762346
106SOX9_26525672_Chip-Seq_HEART_Mouse1.08056060
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07716161
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.07679577
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07379262
110FUS_26573619_Chip-Seq_HEK293_Human1.06965273
111RNF2_27304074_Chip-Seq_NSC_Mouse1.06571924
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06485343
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.06168872
114* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05935317
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05308535
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05086263
117* TBL1_22424771_ChIP-Seq_293T_Human1.05053763
118* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04612370
119KDM2B_26808549_Chip-Seq_REH_Human1.04301467
120* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04244496
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.03262443
122* CRX_20693478_ChIP-Seq_RETINA_Mouse1.03006379
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02718981
124* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02673482
125ER_23166858_ChIP-Seq_MCF-7_Human1.02124602
126* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01982503
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01311577
128SMAD4_21741376_ChIP-Seq_HESCs_Human1.00927915
129* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00772935
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00719411
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00671100
132SMAD3_21741376_ChIP-Seq_HESCs_Human1.00589701
133* RXR_22108803_ChIP-Seq_LS180_Human1.00155797
134* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99743758
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98031209
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97783795
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97745716
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96370339
139* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95616223
140* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95616223
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95027652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79296124
2MP0003880_abnormal_central_pattern3.94225215
3MP0003635_abnormal_synaptic_transmissio3.73059879
4MP0004270_analgesia3.48551343
5MP0009745_abnormal_behavioral_response3.08670426
6MP0009046_muscle_twitch3.04933539
7MP0002063_abnormal_learning/memory/cond2.94690580
8MP0002064_seizures2.80041179
9MP0001968_abnormal_touch/_nociception2.59867391
10MP0002572_abnormal_emotion/affect_behav2.53151190
11MP0001486_abnormal_startle_reflex2.52232953
12MP0009780_abnormal_chondrocyte_physiolo2.51065494
13MP0002272_abnormal_nervous_system2.49746279
14MP0002734_abnormal_mechanical_nocicepti2.47805585
15MP0005423_abnormal_somatic_nervous2.27438736
16MP0010234_abnormal_vibrissa_follicle2.13430511
17MP0001501_abnormal_sleep_pattern2.06825765
18MP0002822_catalepsy2.05317606
19MP0005646_abnormal_pituitary_gland1.98267846
20MP0002735_abnormal_chemical_nociception1.93325567
21MP0008569_lethality_at_weaning1.91542349
22MP0002736_abnormal_nociception_after1.90569203
23MP0002067_abnormal_sensory_capabilities1.88960306
24MP0003787_abnormal_imprinting1.86441956
25MP0001440_abnormal_grooming_behavior1.77709102
26MP0000778_abnormal_nervous_system1.76730381
27MP0010352_gastrointestinal_tract_polyps1.75743137
28MP0002184_abnormal_innervation1.63686591
29MP0002733_abnormal_thermal_nociception1.63469095
30MP0001970_abnormal_pain_threshold1.62066369
31MP0004885_abnormal_endolymph1.61306760
32MP0002557_abnormal_social/conspecific_i1.58859640
33MP0006054_spinal_hemorrhage1.57347938
34MP0003950_abnormal_plasma_membrane1.53355691
35MP0004272_abnormal_basement_membrane1.53210775
36MP0004924_abnormal_behavior1.51353060
37MP0005386_behavior/neurological_phenoty1.51353060
38MP0008438_abnormal_cutaneous_collagen1.49753980
39MP0002938_white_spotting1.48406721
40MP0004811_abnormal_neuron_physiology1.48321607
41MP0001188_hyperpigmentation1.47736724
42MP0004858_abnormal_nervous_system1.44214490
43MP0000955_abnormal_spinal_cord1.43911613
44MP0001177_atelectasis1.42555088
45MP0003122_maternal_imprinting1.41775241
46MP0001984_abnormal_olfaction1.39097930
47MP0000427_abnormal_hair_cycle1.36632387
48MP0002882_abnormal_neuron_morphology1.34395958
49MP0003879_abnormal_hair_cell1.30847871
50MP0002909_abnormal_adrenal_gland1.29206547
51MP0008877_abnormal_DNA_methylation1.28437587
52MP0001502_abnormal_circadian_rhythm1.28332162
53MP0003633_abnormal_nervous_system1.27964340
54MP0001299_abnormal_eye_distance/1.27353952
55MP0002066_abnormal_motor_capabilities/c1.27221558
56MP0004145_abnormal_muscle_electrophysio1.27168019
57MP0003195_calcinosis1.24972787
58MP0000569_abnormal_digit_pigmentation1.24102476
59MP0010368_abnormal_lymphatic_system1.22181391
60MP0006276_abnormal_autonomic_nervous1.19507100
61MP0005645_abnormal_hypothalamus_physiol1.19123411
62MP0005171_absent_coat_pigmentation1.19113381
63MP0003329_amyloid_beta_deposits1.14298913
64MP0005623_abnormal_meninges_morphology1.13466858
65MP0004134_abnormal_chest_morphology1.12591123
66MP0003631_nervous_system_phenotype1.12393465
67MP0005275_abnormal_skin_tensile1.10037177
68MP0004142_abnormal_muscle_tone1.06099695
69MP0000462_abnormal_digestive_system1.05747545
70MP0002295_abnormal_pulmonary_circulatio1.04266819
71MP0000751_myopathy1.04215699
72MP0000013_abnormal_adipose_tissue1.04201150
73MP0003868_abnormal_feces_composition1.04011544
74MP0003755_abnormal_palate_morphology1.02807301
75MP0004085_abnormal_heartbeat1.02667462
76MP0005551_abnormal_eye_electrophysiolog1.02511407
77MP0002152_abnormal_brain_morphology1.01598360
78MP0002168_other_aberrant_phenotype1.01555299
79MP0001944_abnormal_pancreas_morphology1.00601700
80MP0003935_abnormal_craniofacial_develop1.00223209
81MP0000516_abnormal_urinary_system0.99497433
82MP0005367_renal/urinary_system_phenotyp0.99497433
83MP0006072_abnormal_retinal_apoptosis0.98950012
84MP0005408_hypopigmentation0.98708423
85MP0002638_abnormal_pupillary_reflex0.96243216
86MP0005379_endocrine/exocrine_gland_phen0.96227300
87MP0003045_fibrosis0.95852752
88MP0005174_abnormal_tail_pigmentation0.94876066
89MP0000920_abnormal_myelination0.94614606
90MP0003937_abnormal_limbs/digits/tail_de0.94330964
91MP0004084_abnormal_cardiac_muscle0.94138183
92MP0001905_abnormal_dopamine_level0.93275373
93MP0003283_abnormal_digestive_organ0.92660178
94MP0003632_abnormal_nervous_system0.92604231
95MP0000372_irregular_coat_pigmentation0.92117509
96MP0002233_abnormal_nose_morphology0.91349046
97MP0004742_abnormal_vestibular_system0.90899904
98MP0000647_abnormal_sebaceous_gland0.90652541
99MP0008775_abnormal_heart_ventricle0.90602436
100MP0010386_abnormal_urinary_bladder0.89511723
101MP0002102_abnormal_ear_morphology0.89211760
102MP0005253_abnormal_eye_physiology0.88720668
103MP0005248_abnormal_Harderian_gland0.87957837
104MP0003385_abnormal_body_wall0.87781580
105MP0002229_neurodegeneration0.87701852
106MP0000003_abnormal_adipose_tissue0.86382868
107MP0005220_abnormal_exocrine_pancreas0.85342907
108MP0003690_abnormal_glial_cell0.85259234
109MP0002876_abnormal_thyroid_physiology0.85216361
110MP0005409_darkened_coat_color0.84535299
111MP0004043_abnormal_pH_regulation0.84034482
112MP0003634_abnormal_glial_cell0.83485290
113MP0004215_abnormal_myocardial_fiber0.82983033
114MP0002234_abnormal_pharynx_morphology0.81627749
115MP0000631_abnormal_neuroendocrine_gland0.80956619
116MP0010678_abnormal_skin_adnexa0.79954194
117MP0002837_dystrophic_cardiac_calcinosis0.79614300
118MP0004484_altered_response_of0.78881233
119MP0008057_abnormal_DNA_replication0.78854792
120MP0000613_abnormal_salivary_gland0.78794037
121MP0001963_abnormal_hearing_physiology0.78708782
122MP0002896_abnormal_bone_mineralization0.77911808
123MP0002254_reproductive_system_inflammat0.77808364
124MP0002069_abnormal_eating/drinking_beha0.77004922
125MP0003942_abnormal_urinary_system0.75512036
126MP0003183_abnormal_peptide_metabolism0.75288178
127MP0003137_abnormal_impulse_conducting0.75286440
128MP0005503_abnormal_tendon_morphology0.74750480
129MP0001485_abnormal_pinna_reflex0.74150083
130MP0005395_other_phenotype0.73848093
131MP0002752_abnormal_somatic_nervous0.73564764
132MP0005394_taste/olfaction_phenotype0.73117802
133MP0005499_abnormal_olfactory_system0.73117802
134MP0002177_abnormal_outer_ear0.72801456
135MP0002751_abnormal_autonomic_nervous0.72704931
136MP0005187_abnormal_penis_morphology0.70146332
137MP0001756_abnormal_urination0.69850406
138MP0000749_muscle_degeneration0.69611899
139MP0001529_abnormal_vocalization0.69567135
140MP0000534_abnormal_ureter_morphology0.68830042
141MP0003121_genomic_imprinting0.67243468
142MP0002108_abnormal_muscle_morphology0.65650628
143MP0008874_decreased_physiological_sensi0.63723696
144MP0001943_abnormal_respiration0.62721691
145MP0008872_abnormal_physiological_respon0.60677271
146MP0009250_abnormal_appendicular_skeleto0.58232124
147MP0005620_abnormal_muscle_contractility0.57737664
148MP0008961_abnormal_basal_metabolism0.57410566
149MP0003861_abnormal_nervous_system0.54969609
150MP0005595_abnormal_vascular_smooth0.54283653
151MP0003123_paternal_imprinting0.53695468

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.45009684
2Myokymia (HP:0002411)5.02255693
3Focal seizures (HP:0007359)4.68022152
4Epileptic encephalopathy (HP:0200134)4.45086566
5Progressive cerebellar ataxia (HP:0002073)4.16935512
6Febrile seizures (HP:0002373)4.13512053
7Action tremor (HP:0002345)3.95962180
8Atonic seizures (HP:0010819)3.93360170
9Gaze-evoked nystagmus (HP:0000640)3.66951575
10Genetic anticipation (HP:0003743)3.48834836
11Visual hallucinations (HP:0002367)3.47862876
12Broad-based gait (HP:0002136)3.34114072
13Absence seizures (HP:0002121)3.14497405
14Hyperventilation (HP:0002883)3.08377686
15Dysdiadochokinesis (HP:0002075)3.04500427
16Generalized tonic-clonic seizures (HP:0002069)3.03858181
17Urinary bladder sphincter dysfunction (HP:0002839)2.96925547
18Impaired vibration sensation in the lower limbs (HP:0002166)2.92881881
19Scanning speech (HP:0002168)2.87299156
20Dialeptic seizures (HP:0011146)2.82244673
21Termporal pattern (HP:0011008)2.73662213
22Insidious onset (HP:0003587)2.73662213
23Abnormality of the corticospinal tract (HP:0002492)2.68696217
24Truncal ataxia (HP:0002078)2.66921332
25Dysmetria (HP:0001310)2.66133918
26Poor eye contact (HP:0000817)2.57483867
27Ankle clonus (HP:0011448)2.50840774
28Abnormality of the ischium (HP:0003174)2.49786932
29Hyperinsulinemic hypoglycemia (HP:0000825)2.46162373
30Dysmetric saccades (HP:0000641)2.45947681
31Astrocytoma (HP:0009592)2.44780402
32Abnormality of the astrocytes (HP:0100707)2.44780402
33Hypoglycemic coma (HP:0001325)2.44574166
34Depression (HP:0000716)2.44387035
35Excessive salivation (HP:0003781)2.41470657
36Drooling (HP:0002307)2.41470657
37Hypoglycemic seizures (HP:0002173)2.41139475
38Impaired smooth pursuit (HP:0007772)2.39568665
39Hypoplastic ischia (HP:0003175)2.38794525
40Hemiplegia (HP:0002301)2.38748243
41Postural instability (HP:0002172)2.38471615
42Neoplasm of the adrenal cortex (HP:0100641)2.36821198
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36123256
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.36123256
45Supranuclear gaze palsy (HP:0000605)2.35898236
46Aplasia involving bones of the upper limbs (HP:0009823)2.34203837
47Aplasia of the phalanges of the hand (HP:0009802)2.34203837
48Aplasia involving bones of the extremities (HP:0009825)2.34203837
49Hyperglycemia (HP:0003074)2.31064622
50Intention tremor (HP:0002080)2.30048557
51Impaired social interactions (HP:0000735)2.29614522
52Abnormal social behavior (HP:0012433)2.29614522
53Anxiety (HP:0000739)2.27725817
54Absent speech (HP:0001344)2.26700398
55Blue irides (HP:0000635)2.25897754
56Abnormal eating behavior (HP:0100738)2.20279126
57Urinary urgency (HP:0000012)2.19731207
58Neoplasm of the oral cavity (HP:0100649)2.18603929
59Amblyopia (HP:0000646)2.17151137
60Volvulus (HP:0002580)2.16338488
61Abnormality of the lower motor neuron (HP:0002366)2.16086202
62Intestinal atresia (HP:0011100)2.15412001
63Epileptiform EEG discharges (HP:0011182)2.15171572
64Aqueductal stenosis (HP:0002410)2.13829100
65Agitation (HP:0000713)2.09285677
66Hypothermia (HP:0002045)2.07085839
67Impaired vibratory sensation (HP:0002495)2.05983273
68Lower limb muscle weakness (HP:0007340)2.05416585
69Enlarged penis (HP:0000040)2.04854971
70Spastic gait (HP:0002064)2.04431344
71Hemiparesis (HP:0001269)2.04379899
72Ketoacidosis (HP:0001993)2.03863932
73Abnormality of ocular smooth pursuit (HP:0000617)2.02961901
74Torticollis (HP:0000473)2.02034516
75EEG with generalized epileptiform discharges (HP:0011198)2.00870681
76Bradycardia (HP:0001662)1.99309455
77Fetal akinesia sequence (HP:0001989)1.99305550
78Glioma (HP:0009733)1.98435971
79Hamartoma of the eye (HP:0010568)1.92203956
80Stereotypic behavior (HP:0000733)1.90663520
81Metaphyseal dysplasia (HP:0100255)1.90463160
82Overgrowth (HP:0001548)1.89921848
83Hypoplastic labia majora (HP:0000059)1.88875671
84Bifid tongue (HP:0010297)1.88855344
85Hypsarrhythmia (HP:0002521)1.87568928
86Pheochromocytoma (HP:0002666)1.86075329
87Megalencephaly (HP:0001355)1.85274723
88Protruding tongue (HP:0010808)1.83902825
89Lower limb amyotrophy (HP:0007210)1.82160319
90Arterial tortuosity (HP:0005116)1.81899062
91Gait imbalance (HP:0002141)1.80456690
92Large for gestational age (HP:0001520)1.78996064
93Thyroid carcinoma (HP:0002890)1.76533533
94Exotropia (HP:0000577)1.76452873
95Ependymoma (HP:0002888)1.75560327
96Progressive inability to walk (HP:0002505)1.75351380
97Prolonged QT interval (HP:0001657)1.75340101
98Type II lissencephaly (HP:0007260)1.75225778
99Diplopia (HP:0000651)1.74514553
100Abnormality of binocular vision (HP:0011514)1.74514553
101Medial flaring of the eyebrow (HP:0010747)1.74295926
102Bronchomalacia (HP:0002780)1.74106117
103Short chin (HP:0000331)1.72664506
104Status epilepticus (HP:0002133)1.72647124
105Vascular tortuosity (HP:0004948)1.72599421
106Focal dystonia (HP:0004373)1.72221091
107Bradykinesia (HP:0002067)1.71026601
108Abnormal hair whorl (HP:0010721)1.70988825
109Abnormality of endocrine pancreas physiology (HP:0012093)1.70369588
110Abnormality of the pancreatic islet cells (HP:0006476)1.70369588
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.68630352
112Hypoplasia of the fovea (HP:0007750)1.68630352
113Papilledema (HP:0001085)1.68380568
114Abnormality of salivation (HP:0100755)1.67603704
115Abnormality of the labia minora (HP:0012880)1.66346728
116Incomplete penetrance (HP:0003829)1.65010534
117Gait ataxia (HP:0002066)1.64932817
118Bulbous nose (HP:0000414)1.64846202
119Overlapping toe (HP:0001845)1.64416129
120Abnormality of the labia majora (HP:0012881)1.64408910
121Calf muscle hypertrophy (HP:0008981)1.63283820
122Preaxial foot polydactyly (HP:0001841)1.63050249
123Obstructive sleep apnea (HP:0002870)1.62559118
124Inappropriate behavior (HP:0000719)1.62428347
125Generalized hypopigmentation of hair (HP:0011358)1.61938019
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61521435
127Neurofibrillary tangles (HP:0002185)1.61402613
128Abnormal EKG (HP:0003115)1.61307861
129Specific learning disability (HP:0001328)1.60760474
130Cutaneous finger syndactyly (HP:0010554)1.59944804
131Fair hair (HP:0002286)1.59933567
132Abnormal ciliary motility (HP:0012262)1.59743208
133Hypoventilation (HP:0002791)1.59241501
134Hepatoblastoma (HP:0002884)1.58241357
135Widely spaced teeth (HP:0000687)1.57576498
136Pancreatic fibrosis (HP:0100732)1.56377905
137Abnormality of saccadic eye movements (HP:0000570)1.55977565
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55664046
139Macroorchidism (HP:0000053)1.55621418
140Abnormality of the nasal septum (HP:0000419)1.54154725
141Urethral obstruction (HP:0000796)1.53711034
142Papillary thyroid carcinoma (HP:0002895)1.53513240
143Ventricular fibrillation (HP:0001663)1.53477079
144Genital tract atresia (HP:0001827)1.53255224
145Congenital primary aphakia (HP:0007707)1.51869503
146Sensory axonal neuropathy (HP:0003390)1.51050962
147Abnormality of midbrain morphology (HP:0002418)1.49925554
148Molar tooth sign on MRI (HP:0002419)1.49925554
149Muscular hypotonia of the trunk (HP:0008936)1.49436485
150Insulin-resistant diabetes mellitus (HP:0000831)1.49381355
151Small hand (HP:0200055)1.49366042
152Downturned corners of mouth (HP:0002714)1.48737172
153Abnormality of the renal cortex (HP:0011035)1.46799137
154Labial hypoplasia (HP:0000066)1.46523255
155Soft skin (HP:0000977)1.46004399
156Vaginal atresia (HP:0000148)1.45354693
157Limited hip movement (HP:0008800)1.44676355
158Abnormal pancreas size (HP:0012094)1.44400797
159Cardiovascular calcification (HP:0011915)1.43671222
160Nephronophthisis (HP:0000090)1.43332866
161Delayed gross motor development (HP:0002194)1.43153590
162Aortic dissection (HP:0002647)1.42844976
163Abnormality of the intrinsic pathway (HP:0010989)1.42736926
164Symptomatic seizures (HP:0011145)1.41946835
165Buphthalmos (HP:0000557)1.41646747
166Hypopigmentation of the fundus (HP:0007894)1.41638896
167Pancreatic islet-cell hyperplasia (HP:0004510)1.40148253
168Abnormality of the renal medulla (HP:0100957)1.39420222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.42855649
2EPHA43.58879619
3CASK3.04164209
4MAP3K42.89061593
5MAP2K72.61451912
6PRPF4B2.60177889
7MAP3K92.32733063
8MARK12.25991180
9MINK12.21504757
10PRKD32.08089144
11PAK62.02094081
12DAPK21.97579084
13TRIM281.93833629
14LATS11.88403779
15SGK21.66159469
16CAMKK11.65935194
17NTRK21.65109006
18TNIK1.64524264
19MAP2K41.61595639
20SGK2231.60486731
21SGK4941.60486731
22PLK21.56304863
23NTRK11.54425613
24ACVR1B1.48858833
25MAPK131.47313389
26STK31.45534062
27NUAK11.44639672
28AKT31.43136624
29SGK31.39602661
30CAMKK21.39178556
31STK38L1.35699384
32KSR11.32765054
33MKNK21.32760360
34CDK51.31890494
35BRSK21.29057731
36STK381.25428103
37EIF2AK31.25251921
38BMPR1B1.24855872
39KSR21.22036564
40MET1.19334052
41PLK31.17159311
42WNK11.15760079
43PRKCG1.13954377
44OXSR11.12182246
45BCR1.10304223
46FGFR21.09812293
47PRKCH1.07963814
48MST41.07597868
49PTK21.06323884
50SIK31.03747858
51CAMK1G1.02082037
52TRPM71.01924937
53EIF2AK11.01305456
54MAP4K21.00892841
55NEK60.99567886
56PTK2B0.98982718
57CAMK2A0.98915266
58ERBB30.95946810
59LMTK20.94733880
60BMPR20.93729707
61GRK50.93704188
62MAP3K20.93689003
63PAK30.93222566
64MAP3K120.89527781
65SGK10.89053223
66MYLK0.88548873
67WEE10.88317807
68PHKG10.87470045
69PHKG20.87470045
70CAMK2B0.86673649
71DDR20.84603781
72CDK190.83931095
73DAPK10.83315332
74FER0.82663590
75CSNK1G10.82280868
76TGFBR20.81928372
77TYRO30.81212782
78GRK10.81101728
79CAMK10.80729243
80MARK20.80222919
81DMPK0.79214843
82LATS20.79126582
83RET0.78835937
84NLK0.78538844
85PNCK0.78393057
86TAF10.77486257
87PINK10.77272790
88PRKCE0.77220843
89RIPK40.75783712
90UHMK10.75722752
91RIPK10.75641719
92CCNB10.75160092
93STK110.74525044
94TIE10.74273105
95MST1R0.72296769
96CDK30.72200425
97SIK20.71144886
98FRK0.69364899
99ERBB40.68695294
100CAMK2D0.67283883
101INSRR0.66981344
102CDK180.66652743
103FGFR30.64333472
104WNK40.63688121
105TAOK10.63426725
106LIMK10.62899094
107CDK150.61226663
108STK390.59952765
109MUSK0.59523200
110FES0.57830114
111CDK140.57426159
112CSNK1G20.56699955
113PRKAA10.56311885
114MAP3K130.55547907
115CAMK40.55407394
116RPS6KA30.53911801
117PIK3CA0.53488521
118CSNK1A1L0.53443131
119ATM0.53390722
120PBK0.52785711
121CDK11A0.51629579
122CAMK2G0.50198929
123DYRK1A0.48879878
124TNK20.48706605
125BRD40.48508468
126PRKAA20.47718154
127TTK0.47162686
128PDPK10.47115235
129MKNK10.47070554
130PDGFRA0.46844070
131MAP2K10.46208695
132ROCK10.46190402
133PDK10.46026978
134CAMK1D0.45969970
135PRKDC0.45754337
136BRSK10.45391843
137PKN10.45149847
138MAP3K60.44452039
139MAPKAPK50.44424449
140FGFR10.43786489
141PLK10.43510385
142PRKG10.43490995
143TSSK60.43315611
144MAPK100.43209772
145CSNK1G30.42818962
146MAP3K70.42457217
147WNK30.42313321
148ROCK20.41973649

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37178918
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.78233161
3Synaptic vesicle cycle_Homo sapiens_hsa047212.77603594
4Circadian entrainment_Homo sapiens_hsa047132.68133914
5GABAergic synapse_Homo sapiens_hsa047272.53001670
6Glutamatergic synapse_Homo sapiens_hsa047242.49938624
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48057904
8Olfactory transduction_Homo sapiens_hsa047402.45135331
9Long-term potentiation_Homo sapiens_hsa047202.41242502
10Morphine addiction_Homo sapiens_hsa050322.37747186
11Amphetamine addiction_Homo sapiens_hsa050312.20297036
12Salivary secretion_Homo sapiens_hsa049702.05626430
13Insulin secretion_Homo sapiens_hsa049112.04151350
14Vitamin B6 metabolism_Homo sapiens_hsa007501.94982987
15Dopaminergic synapse_Homo sapiens_hsa047281.94395881
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87305250
17Taste transduction_Homo sapiens_hsa047421.79761181
18Gastric acid secretion_Homo sapiens_hsa049711.77710533
19Cholinergic synapse_Homo sapiens_hsa047251.76799870
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76795985
21Long-term depression_Homo sapiens_hsa047301.76724576
22Renin secretion_Homo sapiens_hsa049241.65701818
23Non-homologous end-joining_Homo sapiens_hsa034501.65207610
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63984933
25Propanoate metabolism_Homo sapiens_hsa006401.62166325
26Protein export_Homo sapiens_hsa030601.62154448
27Cocaine addiction_Homo sapiens_hsa050301.58594571
28Serotonergic synapse_Homo sapiens_hsa047261.58418082
29Butanoate metabolism_Homo sapiens_hsa006501.57897263
30Oxytocin signaling pathway_Homo sapiens_hsa049211.55056645
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55023406
32Calcium signaling pathway_Homo sapiens_hsa040201.52010385
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50671451
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42592167
35cAMP signaling pathway_Homo sapiens_hsa040241.41152606
36GnRH signaling pathway_Homo sapiens_hsa049121.39910479
37Selenocompound metabolism_Homo sapiens_hsa004501.39599067
38Type II diabetes mellitus_Homo sapiens_hsa049301.35244795
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31544284
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31023787
41Gap junction_Homo sapiens_hsa045401.29941042
42Axon guidance_Homo sapiens_hsa043601.28500602
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23359122
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18425266
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17361971
46Sulfur metabolism_Homo sapiens_hsa009201.14779805
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13222199
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12717510
49Dilated cardiomyopathy_Homo sapiens_hsa054141.12207392
50Collecting duct acid secretion_Homo sapiens_hsa049661.11480015
51ErbB signaling pathway_Homo sapiens_hsa040121.10866317
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.10587711
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10107133
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08371946
55Estrogen signaling pathway_Homo sapiens_hsa049151.07205002
56Melanogenesis_Homo sapiens_hsa049161.05408118
57Adherens junction_Homo sapiens_hsa045201.04740689
58Lysine degradation_Homo sapiens_hsa003101.01167517
59Glioma_Homo sapiens_hsa052141.01050461
60ABC transporters_Homo sapiens_hsa020101.00535702
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00248515
62TGF-beta signaling pathway_Homo sapiens_hsa043501.00027225
63Phototransduction_Homo sapiens_hsa047440.99816471
64Sphingolipid metabolism_Homo sapiens_hsa006000.97011131
65Dorso-ventral axis formation_Homo sapiens_hsa043200.91513868
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90894613
67Pancreatic secretion_Homo sapiens_hsa049720.90057283
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88443557
69Thyroid hormone synthesis_Homo sapiens_hsa049180.87905074
70Regulation of autophagy_Homo sapiens_hsa041400.87873058
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86071527
72Nitrogen metabolism_Homo sapiens_hsa009100.85415230
73Vibrio cholerae infection_Homo sapiens_hsa051100.84472680
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.84454957
75Tryptophan metabolism_Homo sapiens_hsa003800.82585077
76beta-Alanine metabolism_Homo sapiens_hsa004100.82313926
77Circadian rhythm_Homo sapiens_hsa047100.82207366
78Folate biosynthesis_Homo sapiens_hsa007900.80612823
79Ovarian steroidogenesis_Homo sapiens_hsa049130.80072163
80MAPK signaling pathway_Homo sapiens_hsa040100.78832059
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75996368
82Fatty acid metabolism_Homo sapiens_hsa012120.73043491
83Choline metabolism in cancer_Homo sapiens_hsa052310.72019032
84Ras signaling pathway_Homo sapiens_hsa040140.71190236
85Rap1 signaling pathway_Homo sapiens_hsa040150.70756385
86Protein digestion and absorption_Homo sapiens_hsa049740.67372425
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66465117
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65951573
89Inositol phosphate metabolism_Homo sapiens_hsa005620.65916235
90Wnt signaling pathway_Homo sapiens_hsa043100.64109816
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63896082
92Basal transcription factors_Homo sapiens_hsa030220.62288699
93Fanconi anemia pathway_Homo sapiens_hsa034600.61474254
94Ether lipid metabolism_Homo sapiens_hsa005650.61467661
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61181376
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60769375
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60611095
98Oocyte meiosis_Homo sapiens_hsa041140.59930389
99Fatty acid degradation_Homo sapiens_hsa000710.58480388
100Cardiac muscle contraction_Homo sapiens_hsa042600.57881412
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56420859
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55989404
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54155806
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53862654
105Glucagon signaling pathway_Homo sapiens_hsa049220.53603304
106Endometrial cancer_Homo sapiens_hsa052130.53496235
107Basal cell carcinoma_Homo sapiens_hsa052170.52879145
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52203327
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50788502
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.50740782
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50392025
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49867605
113Focal adhesion_Homo sapiens_hsa045100.48485500
114Tight junction_Homo sapiens_hsa045300.47268748
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47164332
116Bile secretion_Homo sapiens_hsa049760.46295668
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.44799093
118mTOR signaling pathway_Homo sapiens_hsa041500.43730675
119Hedgehog signaling pathway_Homo sapiens_hsa043400.43671534
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43449344
121Endocytosis_Homo sapiens_hsa041440.42771501
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41754723
123Renal cell carcinoma_Homo sapiens_hsa052110.41572457
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41073564
125Melanoma_Homo sapiens_hsa052180.40029707
126Insulin signaling pathway_Homo sapiens_hsa049100.38548760
127Hippo signaling pathway_Homo sapiens_hsa043900.38107244
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37136037
129ECM-receptor interaction_Homo sapiens_hsa045120.35193057
130Alcoholism_Homo sapiens_hsa050340.33509658
131Mineral absorption_Homo sapiens_hsa049780.33494478
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32947893
133Proteoglycans in cancer_Homo sapiens_hsa052050.32947384
134Fatty acid biosynthesis_Homo sapiens_hsa000610.32304375

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