CDC42BPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoskeletal anchoring at plasma membrane (GO:0007016)3.58302487
2layer formation in cerebral cortex (GO:0021819)3.53852132
3hemidesmosome assembly (GO:0031581)3.52615039
4planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50445725
5plasma membrane repair (GO:0001778)3.43430690
6desmosome organization (GO:0002934)3.30981291
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22190712
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21501176
9skin morphogenesis (GO:0043589)3.21246028
10synaptic vesicle maturation (GO:0016188)3.09933878
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08646212
12protein retention in ER lumen (GO:0006621)3.07666110
13cell communication by electrical coupling (GO:0010644)3.06659913
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.05506563
15sodium ion export (GO:0071436)3.04217790
16locomotory exploration behavior (GO:0035641)3.03962902
17establishment of nucleus localization (GO:0040023)2.99932360
18Golgi transport vesicle coating (GO:0048200)2.97182220
19COPI coating of Golgi vesicle (GO:0048205)2.97182220
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96683173
21insulin-like growth factor receptor signaling pathway (GO:0048009)2.94672395
22apoptotic cell clearance (GO:0043277)2.93090740
23macroautophagy (GO:0016236)2.87752585
24stress fiber assembly (GO:0043149)2.81935590
25regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81299018
26synaptic vesicle docking involved in exocytosis (GO:0016081)2.79390551
27regulation of early endosome to late endosome transport (GO:2000641)2.77279501
28barbed-end actin filament capping (GO:0051016)2.77190842
29adherens junction assembly (GO:0034333)2.75083199
30paraxial mesoderm development (GO:0048339)2.70799394
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70479615
32endothelial cell chemotaxis (GO:0035767)2.68124147
33cell communication involved in cardiac conduction (GO:0086065)2.65081793
34negative regulation of cell size (GO:0045792)2.64678631
35activation of protein kinase A activity (GO:0034199)2.63996253
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63546671
37regulation of fatty acid beta-oxidation (GO:0031998)2.63250070
38endodermal cell differentiation (GO:0035987)2.62650268
39regulation of cholesterol homeostasis (GO:2000188)2.58189557
40regulation of clathrin-mediated endocytosis (GO:2000369)2.52928970
41vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52714605
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52440741
43hippo signaling (GO:0035329)2.52287991
44semaphorin-plexin signaling pathway (GO:0071526)2.51759164
45positive regulation of glycogen biosynthetic process (GO:0045725)2.51220693
46protein localization to endosome (GO:0036010)2.50504591
47apical protein localization (GO:0045176)2.49882616
48retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49382681
49regulation of hippo signaling (GO:0035330)2.47903772
50regulation of glucose import in response to insulin stimulus (GO:2001273)2.47661745
51camera-type eye morphogenesis (GO:0048593)2.44982531
52positive regulation of fatty acid beta-oxidation (GO:0032000)2.44250349
53alpha-linolenic acid metabolic process (GO:0036109)2.43614615
54neuron projection extension involved in neuron projection guidance (GO:1902284)2.42052018
55axon extension involved in axon guidance (GO:0048846)2.42052018
56negative regulation of chondrocyte differentiation (GO:0032331)2.42043226
57regulation of synapse structural plasticity (GO:0051823)2.41165343
58cell adhesion mediated by integrin (GO:0033627)2.39739158
59branching involved in salivary gland morphogenesis (GO:0060445)2.39736327
60regulation of p38MAPK cascade (GO:1900744)2.39555512
61regulation of establishment of planar polarity (GO:0090175)2.39503123
62dendrite morphogenesis (GO:0048813)2.38890807
63regulation of axon extension involved in axon guidance (GO:0048841)2.37733173
64negative regulation of catenin import into nucleus (GO:0035414)2.37637671
65mating behavior (GO:0007617)2.36576101
66endothelial cell morphogenesis (GO:0001886)2.36139031
67alanine transport (GO:0032328)2.34089967
68positive regulation of receptor recycling (GO:0001921)2.32763489
69cardiac myofibril assembly (GO:0055003)2.32441378
70regulation of ARF protein signal transduction (GO:0032012)2.31684660
71embryonic foregut morphogenesis (GO:0048617)2.31389399
72cell-substrate junction assembly (GO:0007044)2.30490327
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.29739815
74myelination in peripheral nervous system (GO:0022011)2.29717610
75peripheral nervous system axon ensheathment (GO:0032292)2.29717610
76cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29120270
77activation of Rac GTPase activity (GO:0032863)2.28818683
78cerebellar Purkinje cell layer development (GO:0021680)2.28615059
79glial cell proliferation (GO:0014009)2.28032722
80focal adhesion assembly (GO:0048041)2.27809604
81cell-substrate adherens junction assembly (GO:0007045)2.27809604
82surfactant homeostasis (GO:0043129)2.27761468
83proline transport (GO:0015824)2.26304548
84embryonic retina morphogenesis in camera-type eye (GO:0060059)2.26181411
85membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.26099019
86negative regulation of fatty acid transport (GO:2000192)2.25974518
87low-density lipoprotein particle clearance (GO:0034383)2.25819723
88positive regulation of axon extension (GO:0045773)2.25762390
89collagen fibril organization (GO:0030199)2.25521057
90actin filament bundle assembly (GO:0051017)2.24705989
91actin filament bundle organization (GO:0061572)2.24705989
92negative regulation of vascular permeability (GO:0043116)2.24343167
93cellular potassium ion homeostasis (GO:0030007)2.24311758
94regulation of tight junction assembly (GO:2000810)2.23963248
95positive regulation of p38MAPK cascade (GO:1900745)2.23813360
96dicarboxylic acid biosynthetic process (GO:0043650)2.23003332
97cell migration in hindbrain (GO:0021535)2.22766661
98gap junction assembly (GO:0016264)2.22677491
99basement membrane organization (GO:0071711)2.22268547
100cell migration involved in sprouting angiogenesis (GO:0002042)2.21295253
101neuromuscular process controlling balance (GO:0050885)2.21069289
102cerebellar granule cell differentiation (GO:0021707)2.20981767
103vocalization behavior (GO:0071625)2.19726893
104glutamate secretion (GO:0014047)2.19421840
105eye morphogenesis (GO:0048592)2.18541527
106peptidyl-lysine dimethylation (GO:0018027)2.18452568
107amino acid import (GO:0043090)2.18004451
108positive regulation of synapse maturation (GO:0090129)2.17947286
109establishment or maintenance of bipolar cell polarity (GO:0061245)2.17938651
110establishment or maintenance of apical/basal cell polarity (GO:0035088)2.17938651
111cell junction maintenance (GO:0034331)2.17726831
112asymmetric protein localization (GO:0008105)2.17609306
113axon extension (GO:0048675)2.17475747
114neuron projection extension (GO:1990138)2.16955030
115positive regulation of glycogen metabolic process (GO:0070875)2.16794884
116bundle of His cell to Purkinje myocyte communication (GO:0086069)2.15619575
117chondrocyte proliferation (GO:0035988)2.15250620
118cell junction assembly (GO:0034329)2.15137146
119epithelial cell-cell adhesion (GO:0090136)2.14629893
120negative regulation of sodium ion transport (GO:0010766)2.13813171
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.13574965
122establishment of apical/basal cell polarity (GO:0035089)2.12721581
123regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.12533725
124branching involved in mammary gland duct morphogenesis (GO:0060444)2.11536113
125convergent extension (GO:0060026)2.11471046
126endocytic recycling (GO:0032456)2.11120623
127polarized epithelial cell differentiation (GO:0030859)2.10975042
128growth hormone receptor signaling pathway (GO:0060396)2.10302495
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.10202121
130dendritic spine morphogenesis (GO:0060997)2.09972429
131cell volume homeostasis (GO:0006884)2.09968488
132carnitine shuttle (GO:0006853)2.09848386
133neural tube development (GO:0021915)2.08933313
134regulation of ARF GTPase activity (GO:0032312)2.08930161
135cytoplasmic mRNA processing body assembly (GO:0033962)2.08664467
136positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.08437750
137neuron remodeling (GO:0016322)2.08174655
138regulation of NFAT protein import into nucleus (GO:0051532)2.08160021
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.08134759
140blood vessel endothelial cell migration (GO:0043534)2.07640599
141midgut development (GO:0007494)2.06458799
142fatty acid transmembrane transport (GO:1902001)2.05829967
143gastrulation with mouth forming second (GO:0001702)2.05721264
144adherens junction organization (GO:0034332)2.05670775
145lysine metabolic process (GO:0006553)2.04654082
146lysine catabolic process (GO:0006554)2.04654082
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.04443698
148cellular sodium ion homeostasis (GO:0006883)2.03361807
149membrane repolarization during action potential (GO:0086011)2.02152932
150protein targeting to plasma membrane (GO:0072661)2.02042540
151cell-cell junction maintenance (GO:0045217)2.01308177
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.01028647
153growth hormone secretion (GO:0030252)1.98987734
154vascular endothelial growth factor signaling pathway (GO:0038084)1.98948199
155positive regulation of fatty acid oxidation (GO:0046321)1.98335354
156regulation of cholesterol storage (GO:0010885)1.98147809
157protein heterotrimerization (GO:0070208)1.97469480
158regulation of fatty acid oxidation (GO:0046320)1.95812743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39644467
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36073200
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08893529
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02077979
5KDM2B_26808549_Chip-Seq_K562_Human1.96403926
6DROSHA_22980978_ChIP-Seq_HELA_Human1.91000924
7CLOCK_20551151_ChIP-Seq_293T_Human1.90563225
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88452608
9ESR2_21235772_ChIP-Seq_MCF-7_Human1.88199726
10* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87168644
11ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85835100
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83666725
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83386232
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.82431596
15ZNF263_19887448_ChIP-Seq_K562_Human1.80295552
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79547141
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78082523
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.74176073
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73833587
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73022646
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71152078
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69549552
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.69332055
24* RXR_22158963_ChIP-Seq_LIVER_Mouse1.66784531
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61784069
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60457185
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56344958
28* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56183174
29* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54559070
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54121585
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53345372
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53345372
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52834506
34KDM2B_26808549_Chip-Seq_DND41_Human1.49988514
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49629948
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49210139
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.47828144
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47317089
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46267026
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46260240
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.46071914
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.44434139
43LXR_22292898_ChIP-Seq_THP-1_Human1.40030968
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39778993
45* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39520355
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.39020863
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36288762
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36149303
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.35988466
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.35538262
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29917606
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28217716
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.26489126
54TET1_21490601_ChIP-Seq_MESCs_Mouse1.26251980
55RACK7_27058665_Chip-Seq_MCF-7_Human1.25750643
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25256953
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24336530
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22638101
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.21976788
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.21976788
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.21281983
62CREB1_26743006_Chip-Seq_LNCaP_Human1.21132007
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20500579
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.19264031
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19212815
66* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19018932
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18571451
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18281914
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17671192
70AHR_22903824_ChIP-Seq_MCF-7_Human1.17670948
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17588654
72EZH2_22144423_ChIP-Seq_EOC_Human1.16265042
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16224507
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.15698862
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15318982
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.15202860
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13157480
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.12368443
79* TP53_22127205_ChIP-Seq_IMR90_Human1.11642070
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11132169
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.10941057
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10088024
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09891469
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08978944
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.08921669
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08643546
87* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08172406
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.08015024
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07379444
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07207339
91* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07068028
92* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06923432
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06808939
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06808939
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06776002
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06684678
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06290536
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05878907
99SMC4_20622854_ChIP-Seq_HELA_Human1.04760408
100CTCF_27219007_Chip-Seq_Bcells_Human1.04541768
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.03772094
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03537890
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03494108
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02676478
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02632585
106TP53_16413492_ChIP-PET_HCT116_Human1.01478604
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01029881
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00932591
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00727422
110AR_19668381_ChIP-Seq_PC3_Human1.00706038
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00497843
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00483247
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.00140692
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99544203
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99459745
116TCF7_22412390_ChIP-Seq_EML_Mouse0.97227730
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.96803483
118ATF3_27146783_Chip-Seq_COLON_Human0.96765464
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95980793
120* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95965923
121EED_16625203_ChIP-ChIP_MESCs_Mouse0.94446312
122* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94099886
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.93590909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.41600014
2MP0004859_abnormal_synaptic_plasticity3.14361034
3MP0005409_darkened_coat_color2.55220237
4MP0009780_abnormal_chondrocyte_physiolo2.46035385
5MP0008438_abnormal_cutaneous_collagen2.44247443
6MP0004272_abnormal_basement_membrane2.41482196
7MP0005623_abnormal_meninges_morphology2.40644499
8MP0010234_abnormal_vibrissa_follicle2.31748022
9MP0003283_abnormal_digestive_organ2.31111528
10MP0004858_abnormal_nervous_system2.25189007
11MP0000569_abnormal_digit_pigmentation2.22738136
12MP0005360_urolithiasis2.02657894
13MP0000751_myopathy2.00084933
14MP0010368_abnormal_lymphatic_system1.88377499
15MP0004084_abnormal_cardiac_muscle1.88190537
16MP0002139_abnormal_hepatobiliary_system1.85971577
17MP0005167_abnormal_blood-brain_barrier1.83194280
18MP0003252_abnormal_bile_duct1.81715173
19MP0000579_abnormal_nail_morphology1.80340894
20MP0005076_abnormal_cell_differentiation1.80075493
21MP0000537_abnormal_urethra_morphology1.72413114
22MP0008961_abnormal_basal_metabolism1.72317418
23MP0010030_abnormal_orbit_morphology1.64439563
24MP0003566_abnormal_cell_adhesion1.61796657
25MP0004130_abnormal_muscle_cell1.60695336
26MP0002909_abnormal_adrenal_gland1.54368599
27MP0003941_abnormal_skin_development1.53215670
28MP0003045_fibrosis1.52867760
29MP0002796_impaired_skin_barrier1.49808431
30MP0002060_abnormal_skin_morphology1.48138491
31MP0001958_emphysema1.45820545
32MP0006138_congestive_heart_failure1.43247142
33MP0004233_abnormal_muscle_weight1.42509329
34MP0005275_abnormal_skin_tensile1.42040183
35MP0003091_abnormal_cell_migration1.40953846
36MP0004270_analgesia1.39587041
37MP0010352_gastrointestinal_tract_polyps1.38386092
38MP0005187_abnormal_penis_morphology1.37258146
39MP0000566_synostosis1.36462313
40MP0003300_gastrointestinal_ulcer1.35882226
41MP0004185_abnormal_adipocyte_glucose1.34210506
42MP0000762_abnormal_tongue_morphology1.33559582
43MP0003329_amyloid_beta_deposits1.33232980
44MP0004087_abnormal_muscle_fiber1.32414551
45MP0001849_ear_inflammation1.32059083
46MP0002837_dystrophic_cardiac_calcinosis1.31966194
47MP0003453_abnormal_keratinocyte_physiol1.31680052
48MP0000013_abnormal_adipose_tissue1.28895685
49MP0001348_abnormal_lacrimal_gland1.28161957
50MP0003115_abnormal_respiratory_system1.27764445
51MP0000534_abnormal_ureter_morphology1.26525648
52MP0000462_abnormal_digestive_system1.26500149
53MP0000003_abnormal_adipose_tissue1.26006238
54MP0005248_abnormal_Harderian_gland1.25330203
55MP0010329_abnormal_lipoprotein_level1.24652429
56MP0002896_abnormal_bone_mineralization1.24099643
57MP0005666_abnormal_adipose_tissue1.20388113
58MP0005365_abnormal_bile_salt1.20224428
59MP0003635_abnormal_synaptic_transmissio1.19731195
60MP0005085_abnormal_gallbladder_physiolo1.19156686
61MP0005375_adipose_tissue_phenotype1.18666626
62MP0004885_abnormal_endolymph1.17954549
63MP0002249_abnormal_larynx_morphology1.16733884
64MP0000733_abnormal_muscle_development1.15277906
65MP0003279_aneurysm1.14357379
66MP0009840_abnormal_foam_cell1.14133633
67MP0002877_abnormal_melanocyte_morpholog1.11534557
68MP0009053_abnormal_anal_canal1.11175892
69MP0003634_abnormal_glial_cell1.10053549
70MP0010630_abnormal_cardiac_muscle1.07970373
71MP0005508_abnormal_skeleton_morphology1.05440115
72MP0000467_abnormal_esophagus_morphology1.04280043
73MP0001879_abnormal_lymphatic_vessel1.03594555
74MP0000428_abnormal_craniofacial_morphol1.02891272
75MP0004036_abnormal_muscle_relaxation1.02471260
76MP0003385_abnormal_body_wall1.02261843
77MP0003119_abnormal_digestive_system1.02146369
78MP0005670_abnormal_white_adipose1.02134616
79MP0003879_abnormal_hair_cell1.01132456
80MP0005058_abnormal_lysosome_morphology1.00870059
81MP0001299_abnormal_eye_distance/1.00741556
82MP0005501_abnormal_skin_physiology0.99716817
83MP0009384_cardiac_valve_regurgitation0.99657341
84MP0002089_abnormal_postnatal_growth/wei0.96156486
85MP0002269_muscular_atrophy0.95398740
86MP0002168_other_aberrant_phenotype0.94163263
87MP0000678_abnormal_parathyroid_gland0.94074937
88MP0005257_abnormal_intraocular_pressure0.89452766
89MP0005595_abnormal_vascular_smooth0.89167136
90MP0005330_cardiomyopathy0.88820657
91MP0002063_abnormal_learning/memory/cond0.86999589
92MP0001915_intracranial_hemorrhage0.86519768
93MP0008775_abnormal_heart_ventricle0.85792035
94MP0004782_abnormal_surfactant_physiolog0.85288568
95MP0002108_abnormal_muscle_morphology0.84549807
96MP0000747_muscle_weakness0.84543958
97MP0000759_abnormal_skeletal_muscle0.83545680
98MP0004085_abnormal_heartbeat0.83510213
99MP0004215_abnormal_myocardial_fiber0.82211660
100MP0005385_cardiovascular_system_phenoty0.80806542
101MP0001544_abnormal_cardiovascular_syste0.80806542
102MP0002697_abnormal_eye_size0.80648261
103MP0004264_abnormal_extraembryonic_tissu0.80438413
104MP0003123_paternal_imprinting0.79841653
105MP0002972_abnormal_cardiac_muscle0.79835280
106MP0003191_abnormal_cellular_cholesterol0.78765073
107MP0005620_abnormal_muscle_contractility0.78586962
108MP0003950_abnormal_plasma_membrane0.78189115
109MP0002295_abnormal_pulmonary_circulatio0.78083877
110MP0002925_abnormal_cardiovascular_devel0.77649946
111MP0000767_abnormal_smooth_muscle0.77288896
112MP0000778_abnormal_nervous_system0.77225911
113MP0005503_abnormal_tendon_morphology0.76272674
114MP0003122_maternal_imprinting0.75648170
115MP0000432_abnormal_head_morphology0.75143230
116MP0000604_amyloidosis0.74679433
117MP0003878_abnormal_ear_physiology0.74125320
118MP0005377_hearing/vestibular/ear_phenot0.74125320
119MP0002234_abnormal_pharynx_morphology0.73956675
120MP0002116_abnormal_craniofacial_bone0.72528528
121MP0003942_abnormal_urinary_system0.72379219
122MP0009672_abnormal_birth_weight0.72340653
123MP0005023_abnormal_wound_healing0.72223176
124MP0002128_abnormal_blood_circulation0.72125022
125MP0001177_atelectasis0.71710970
126MP0002118_abnormal_lipid_homeostasis0.71201017
127MP0004811_abnormal_neuron_physiology0.70948038
128MP0002090_abnormal_vision0.69930857
129MP0002653_abnormal_ependyma_morphology0.69729784
130MP0001614_abnormal_blood_vessel0.69356314
131MP0000266_abnormal_heart_morphology0.69190956
132MP0010771_integument_phenotype0.68907879
133MP0004145_abnormal_muscle_electrophysio0.68817127
134MP0003935_abnormal_craniofacial_develop0.68590623
135MP0005451_abnormal_body_composition0.67883870
136MP0002098_abnormal_vibrissa_morphology0.66237043
137MP0003690_abnormal_glial_cell0.65464696
138MP0009250_abnormal_appendicular_skeleto0.63919013
139MP0000920_abnormal_myelination0.59932008
140MP0010678_abnormal_skin_adnexa0.59677571
141MP0002092_abnormal_eye_morphology0.59443504

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.49798602
2Shallow orbits (HP:0000586)3.28673777
3Protrusio acetabuli (HP:0003179)3.18861937
4Vascular tortuosity (HP:0004948)3.11264884
5Distal upper limb amyotrophy (HP:0007149)2.97139769
6Upper limb amyotrophy (HP:0009129)2.97139769
7Abnormality of the lower motor neuron (HP:0002366)2.86191437
8Lymphangioma (HP:0100764)2.80086813
9Obstructive sleep apnea (HP:0002870)2.72722314
10Hand muscle atrophy (HP:0009130)2.72436564
11Hyperacusis (HP:0010780)2.69240528
12Neurofibrillary tangles (HP:0002185)2.58842011
13Broad metatarsal (HP:0001783)2.55943224
14Ulnar bowing (HP:0003031)2.53761299
15Premature rupture of membranes (HP:0001788)2.49153392
16Deep venous thrombosis (HP:0002625)2.49146844
17Aneurysm (HP:0002617)2.48232184
18Bladder diverticulum (HP:0000015)2.48117433
19Ankle contracture (HP:0006466)2.47564344
20Turricephaly (HP:0000262)2.47530278
21Broad face (HP:0000283)2.47484720
22Neonatal short-limb short stature (HP:0008921)2.45237494
23Wormian bones (HP:0002645)2.44193695
24Subacute progressive viral hepatitis (HP:0006572)2.42471074
25Cervical subluxation (HP:0003308)2.42068282
26Elfin facies (HP:0004428)2.41702806
27Increased connective tissue (HP:0009025)2.39211770
28Distal lower limb amyotrophy (HP:0008944)2.32912010
29Mitral valve prolapse (HP:0001634)2.32225778
30Renovascular hypertension (HP:0100817)2.29274441
31Enlarged penis (HP:0000040)2.25311768
32Right ventricular cardiomyopathy (HP:0011663)2.23956118
33Hyporeflexia of lower limbs (HP:0002600)2.18474766
34Short nail (HP:0001799)2.17565149
35Insomnia (HP:0100785)2.17238137
36Abnormality of dentin (HP:0010299)2.16826704
37Long toe (HP:0010511)2.13460680
38Mitral regurgitation (HP:0001653)2.13438821
39Aortic aneurysm (HP:0004942)2.12414075
40Flat acetabular roof (HP:0003180)2.12224517
41Difficulty running (HP:0009046)2.09755318
42Macroorchidism (HP:0000053)2.08929033
43Vertebral compression fractures (HP:0002953)2.08233143
44Bundle branch block (HP:0011710)2.08225440
45Renal duplication (HP:0000075)2.05234451
46Aplasia involving bones of the upper limbs (HP:0009823)2.02867096
47Aplasia of the phalanges of the hand (HP:0009802)2.02867096
48Aplasia involving bones of the extremities (HP:0009825)2.02867096
49Distal lower limb muscle weakness (HP:0009053)2.01284071
50Difficulty climbing stairs (HP:0003551)2.01005849
51Bowel diverticulosis (HP:0005222)2.00891382
52Dysmetric saccades (HP:0000641)1.99289301
53Vertebral arch anomaly (HP:0008438)1.99143202
54Advanced eruption of teeth (HP:0006288)1.98478812
55Osteolytic defects of the hand bones (HP:0009699)1.97999611
56Osteolytic defects of the phalanges of the hand (HP:0009771)1.97999611
57Asymmetry of the thorax (HP:0001555)1.97877487
58Disproportionate tall stature (HP:0001519)1.97470589
59Blue sclerae (HP:0000592)1.97179335
60Increased variability in muscle fiber diameter (HP:0003557)1.96028113
61Pointed chin (HP:0000307)1.94972449
62Bronchomalacia (HP:0002780)1.94726193
63Mildly elevated creatine phosphokinase (HP:0008180)1.93025678
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.92556335
65Action tremor (HP:0002345)1.92316408
66Soft skin (HP:0000977)1.91172724
67Hemiplegia (HP:0002301)1.89743369
68Dilatation of the ascending aorta (HP:0005111)1.89221331
69Aortic dissection (HP:0002647)1.88735986
70Sudden death (HP:0001699)1.87875538
71Natal tooth (HP:0000695)1.86545542
72Abnormality of the Achilles tendon (HP:0005109)1.84763904
73Atrophic scars (HP:0001075)1.82179591
74Ventricular fibrillation (HP:0001663)1.81448676
75Joint laxity (HP:0001388)1.81387783
76Achilles tendon contracture (HP:0001771)1.81356473
77Genu recurvatum (HP:0002816)1.80805152
78Buphthalmos (HP:0000557)1.80447545
79Overgrowth (HP:0001548)1.78430116
80Lower limb amyotrophy (HP:0007210)1.78137604
81Scapular winging (HP:0003691)1.77769201
82Striae distensae (HP:0001065)1.77756756
83Overriding aorta (HP:0002623)1.76230883
84Spinal cord compression (HP:0002176)1.75505482
85Short 4th metacarpal (HP:0010044)1.74870404
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74870404
87Thin bony cortex (HP:0002753)1.74699475
88Coronal craniosynostosis (HP:0004440)1.73916716
89Hepatoblastoma (HP:0002884)1.73415959
90Hammertoe (HP:0001765)1.71236564
91Back pain (HP:0003418)1.70759975
92Focal segmental glomerulosclerosis (HP:0000097)1.70411321
93Cerebral inclusion bodies (HP:0100314)1.70247423
94Biconcave vertebral bodies (HP:0004586)1.69823722
95Flat cornea (HP:0007720)1.69676926
96Abnormality of the 4th metacarpal (HP:0010012)1.68916884
97Mitral stenosis (HP:0001718)1.68897433
98Myokymia (HP:0002411)1.68663431
99Wide anterior fontanel (HP:0000260)1.68503579
100Deviation of the hallux (HP:0010051)1.68396351
101Neoplasm of the heart (HP:0100544)1.68054347
102Ankyloglossia (HP:0010296)1.67794554
103Insidious onset (HP:0003587)1.65933822
104Termporal pattern (HP:0011008)1.65933822
105Hallux valgus (HP:0001822)1.65229770
106Spinal rigidity (HP:0003306)1.65169279
107Ankle clonus (HP:0011448)1.64689639
108Hypoventilation (HP:0002791)1.64329575
109Rectal prolapse (HP:0002035)1.63511684
110Genetic anticipation (HP:0003743)1.62137433
111Nuclear cataract (HP:0100018)1.61930316
112Abnormality of the acetabulum (HP:0003170)1.61184935
113Abnormality of the astrocytes (HP:0100707)1.61159354
114Astrocytoma (HP:0009592)1.61159354
115Type 1 muscle fiber predominance (HP:0003803)1.60423603
116Hyperparathyroidism (HP:0000843)1.59384196
117Xanthomatosis (HP:0000991)1.58666364
118Abnormal ossification of hand bones (HP:0005921)1.57936598
119Precocious puberty (HP:0000826)1.57091318
120Visceral angiomatosis (HP:0100761)1.56755049
121Torticollis (HP:0000473)1.56202504
122Fibroma (HP:0010614)1.56009296
123Skin nodule (HP:0200036)1.55888958
124Hyperextensible skin (HP:0000974)1.55540242
125Congenital glaucoma (HP:0001087)1.55037231
126Neonatal death (HP:0003811)1.54805332
127Urinary bladder sphincter dysfunction (HP:0002839)1.54458546
128Abnormality of skeletal muscle fiber size (HP:0012084)1.54265592
129Peritonitis (HP:0002586)1.53745636
130Atrioventricular block (HP:0001678)1.53737336
131Fragile skin (HP:0001030)1.51951497
132Hemangiomatosis (HP:0007461)1.51662384
133Supranuclear gaze palsy (HP:0000605)1.51659883
134Bowing of the arm (HP:0006488)1.51346266
135Bowed forearm bones (HP:0003956)1.51346266
136Esophageal varix (HP:0002040)1.50220331
137Muscle fiber splitting (HP:0003555)1.50172050
138Resting tremor (HP:0002322)1.50115721
139Elbow flexion contracture (HP:0002987)1.50093973
140Hypoplastic ischia (HP:0003175)1.49992726
141Long palpebral fissure (HP:0000637)1.49835760
142Epidermoid cyst (HP:0200040)1.49797903
143Aortic regurgitation (HP:0001659)1.49718558
144Hamartoma of the eye (HP:0010568)1.49605183
145Arnold-Chiari malformation (HP:0002308)1.48201409
146Arterial tortuosity (HP:0005116)1.48048968
147Wrist flexion contracture (HP:0001239)1.47487366
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46433748
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.45857548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.92819677
2RIPK12.99219150
3PKN22.95916054
4LATS22.50632458
5PRKD32.43517340
6LATS12.34894520
7MAP3K92.30986026
8PDGFRA2.19854612
9TTN2.12050700
10SMG11.93977181
11PAK61.84333027
12DDR21.80743718
13KSR21.79328042
14PTK61.78474677
15DAPK21.74790921
16LMTK21.71600429
17MARK11.66057359
18TYRO31.64476239
19ICK1.62200597
20CAMK1G1.55467171
21SIK11.52138034
22CDK121.51808007
23CAMKK11.48190917
24CAMK1D1.44939310
25DMPK1.44746855
26TAOK11.44548088
27ERN11.41939721
28STK381.41727830
29BMX1.40821890
30PRPF4B1.37803991
31PTK21.36301815
32NTRK11.31339796
33TESK11.30228452
34RET1.29702800
35EPHB21.27238889
36MAP3K41.26099722
37FER1.26099372
38NTRK31.25254411
39MAP3K21.21335804
40IRAK31.20159464
41PAK31.16233330
42SCYL21.13939515
43MAP3K101.09250823
44MINK11.06318577
45ALK1.04785939
46KSR11.03806768
47EPHA41.01553858
48NEK11.01383376
49MYLK0.99417720
50* MTOR0.98806254
51PHKG20.98245277
52PHKG10.98245277
53ARAF0.96827381
54EEF2K0.96752946
55PAK20.92511135
56MET0.90304072
57PDGFRB0.90019219
58PRKCH0.88480913
59PRKD20.87495483
60TIE10.86823184
61MAP2K40.86391509
62CDC42BPA0.85486421
63MST1R0.83768747
64SIK20.82841673
65PTK2B0.80575600
66ROCK20.77942417
67SGK30.75848439
68MOS0.75403221
69FGFR10.73374479
70PAK40.72888118
71FGFR40.72356527
72MAP3K70.71510834
73NTRK20.71477405
74LIMK10.70738082
75ERBB20.70465577
76STK110.67570731
77ROCK10.67339476
78EPHA20.66634776
79FGFR20.66039725
80PRKD10.61528652
81CDK50.61480854
82CAMK2B0.61299852
83MARK20.59992034
84MAP2K10.59722715
85NEK90.59209721
86EPHB10.59048477
87PDPK10.58231910
88MAP3K60.57869279
89AKT30.57363286
90WNK10.57295295
91CAMK2G0.55926564
92PRKAA10.54420060
93RPS6KA20.53184646
94SGK4940.52881172
95SGK2230.52881172
96STK38L0.50778706
97NEK60.50249115
98MAP3K130.48216636
99PRKCZ0.47955060
100CDK150.47510043
101FRK0.46519405
102ILK0.46464975
103TRPM70.46411058
104MAPKAPK30.46121751
105MAP3K10.45939831
106CDK180.43276135
107CDK11A0.42799356
108STK30.42752357
109CDK60.42111404
110CAMK2D0.41705623
111TGFBR20.40317165
112RPS6KA30.40130164
113CAMK40.39836727
114RPS6KC10.39444024
115RPS6KL10.39444024
116BRAF0.39131728
117AKT20.37764230
118PDK10.37375962
119SGK10.37279151
120LRRK20.37180001
121SRC0.37143311
122MAP2K20.36540366
123GSK3A0.36189881
124MAP3K30.35458676
125PRKG20.34955023
126ERBB40.34411083
127WNK40.34268524
128FGFR30.33961686
129PDK30.33376795
130PDK40.33376795
131DAPK30.31504597
132MAPK100.30715952

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.10426669
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00336310
3Arginine biosynthesis_Homo sapiens_hsa002201.68272481
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62634668
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57284929
6Bile secretion_Homo sapiens_hsa049761.56559038
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46913258
8Notch signaling pathway_Homo sapiens_hsa043301.33681507
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33178164
10Dilated cardiomyopathy_Homo sapiens_hsa054141.30687821
11Type II diabetes mellitus_Homo sapiens_hsa049301.29073177
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25743384
13Focal adhesion_Homo sapiens_hsa045101.25403548
14ECM-receptor interaction_Homo sapiens_hsa045121.23617449
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23163294
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20793055
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19428418
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18501984
19Thyroid cancer_Homo sapiens_hsa052161.17414014
20Lysine degradation_Homo sapiens_hsa003101.16074630
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15691669
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13966963
23Adherens junction_Homo sapiens_hsa045201.13949074
24PPAR signaling pathway_Homo sapiens_hsa033201.13608981
25Dorso-ventral axis formation_Homo sapiens_hsa043201.13547130
26Glioma_Homo sapiens_hsa052141.11854991
27Estrogen signaling pathway_Homo sapiens_hsa049151.09937994
28mTOR signaling pathway_Homo sapiens_hsa041501.09826438
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.08325035
30Gastric acid secretion_Homo sapiens_hsa049711.07441520
31Amoebiasis_Homo sapiens_hsa051461.05077734
32Proteoglycans in cancer_Homo sapiens_hsa052051.03420652
33Synaptic vesicle cycle_Homo sapiens_hsa047211.02968643
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02868974
35Fatty acid degradation_Homo sapiens_hsa000711.02648724
36MicroRNAs in cancer_Homo sapiens_hsa052061.02558067
37Circadian entrainment_Homo sapiens_hsa047131.01626490
38Insulin resistance_Homo sapiens_hsa049311.01259890
39Insulin secretion_Homo sapiens_hsa049111.00394144
40Endometrial cancer_Homo sapiens_hsa052130.98609029
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.98320572
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98006576
43Vitamin B6 metabolism_Homo sapiens_hsa007500.97612418
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97075803
45GnRH signaling pathway_Homo sapiens_hsa049120.95094950
46Salivary secretion_Homo sapiens_hsa049700.95071934
47Gap junction_Homo sapiens_hsa045400.94991450
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93432494
49Fatty acid metabolism_Homo sapiens_hsa012120.92570647
50Renin secretion_Homo sapiens_hsa049240.92345667
51Axon guidance_Homo sapiens_hsa043600.91956706
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91379494
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.90872582
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90487639
55Long-term potentiation_Homo sapiens_hsa047200.89918108
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87250858
57Tight junction_Homo sapiens_hsa045300.86997303
58Hippo signaling pathway_Homo sapiens_hsa043900.86975570
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86347956
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85589704
61Oxytocin signaling pathway_Homo sapiens_hsa049210.85463147
62Melanogenesis_Homo sapiens_hsa049160.84198347
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83867936
64Protein digestion and absorption_Homo sapiens_hsa049740.83702185
65Insulin signaling pathway_Homo sapiens_hsa049100.83692215
66Choline metabolism in cancer_Homo sapiens_hsa052310.83430919
67Cholinergic synapse_Homo sapiens_hsa047250.83234378
68Fatty acid biosynthesis_Homo sapiens_hsa000610.82992149
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81476427
70Butanoate metabolism_Homo sapiens_hsa006500.81359305
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.80823105
72Pancreatic cancer_Homo sapiens_hsa052120.80594354
73GABAergic synapse_Homo sapiens_hsa047270.80571356
74Vibrio cholerae infection_Homo sapiens_hsa051100.79999096
75Olfactory transduction_Homo sapiens_hsa047400.79352061
76Glucagon signaling pathway_Homo sapiens_hsa049220.78800669
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.78504133
78Other glycan degradation_Homo sapiens_hsa005110.78399856
79AMPK signaling pathway_Homo sapiens_hsa041520.77949008
80Fat digestion and absorption_Homo sapiens_hsa049750.76279858
81Prostate cancer_Homo sapiens_hsa052150.75251324
82Inositol phosphate metabolism_Homo sapiens_hsa005620.75015610
83Glutamatergic synapse_Homo sapiens_hsa047240.74612296
84Dopaminergic synapse_Homo sapiens_hsa047280.74144091
85Bladder cancer_Homo sapiens_hsa052190.74111864
86cAMP signaling pathway_Homo sapiens_hsa040240.74106984
87Tryptophan metabolism_Homo sapiens_hsa003800.73839101
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.73414580
89Thyroid hormone synthesis_Homo sapiens_hsa049180.72782084
90Renal cell carcinoma_Homo sapiens_hsa052110.72253867
91VEGF signaling pathway_Homo sapiens_hsa043700.71681839
92Complement and coagulation cascades_Homo sapiens_hsa046100.71568155
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.71433060
94Chronic myeloid leukemia_Homo sapiens_hsa052200.70912833
95ErbB signaling pathway_Homo sapiens_hsa040120.70846598
96Rap1 signaling pathway_Homo sapiens_hsa040150.69462127
97Endocytosis_Homo sapiens_hsa041440.69122632
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68818619
99Wnt signaling pathway_Homo sapiens_hsa043100.68683928
100Cocaine addiction_Homo sapiens_hsa050300.68558758
101Amphetamine addiction_Homo sapiens_hsa050310.68436867
102Pathways in cancer_Homo sapiens_hsa052000.66673774
103Galactose metabolism_Homo sapiens_hsa000520.65200482
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64474373
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64180804
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63655071
107Melanoma_Homo sapiens_hsa052180.63459540
108Small cell lung cancer_Homo sapiens_hsa052220.63205138
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.61835934
110Prion diseases_Homo sapiens_hsa050200.61382606
111Prolactin signaling pathway_Homo sapiens_hsa049170.60757906
112Non-small cell lung cancer_Homo sapiens_hsa052230.59477114
113Fructose and mannose metabolism_Homo sapiens_hsa000510.59059447
114Basal cell carcinoma_Homo sapiens_hsa052170.58977125
115Colorectal cancer_Homo sapiens_hsa052100.58763591
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58577759
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.58550927
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58439715
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58060076
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56402569
121Ovarian steroidogenesis_Homo sapiens_hsa049130.55636162
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54450592
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53925483
124Morphine addiction_Homo sapiens_hsa050320.53641568
125Hedgehog signaling pathway_Homo sapiens_hsa043400.51806604

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