CDC42EP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.91677447
2axon ensheathment in central nervous system (GO:0032291)9.91677447
3fatty acid elongation (GO:0030497)6.88560553
4ensheathment of neurons (GO:0007272)5.87609427
5axon ensheathment (GO:0008366)5.87609427
6myelination (GO:0042552)5.83164690
7long-chain fatty acid biosynthetic process (GO:0042759)5.67087328
8cholesterol biosynthetic process (GO:0006695)4.59958886
9myelin maintenance (GO:0043217)4.50100462
10adhesion of symbiont to host cell (GO:0044650)4.43928091
11virion attachment to host cell (GO:0019062)4.43928091
12creatine metabolic process (GO:0006600)4.18680997
13response to peptidoglycan (GO:0032494)4.18325139
14sterol biosynthetic process (GO:0016126)4.12809646
15negative regulation of neurotransmitter secretion (GO:0046929)4.08821389
16negative regulation of protein localization to cell surface (GO:2000009)4.04279018
17positive regulation by symbiont of host defense response (GO:0052509)4.01327645
18modulation by symbiont of host defense response (GO:0052031)4.01327645
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.01327645
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.01327645
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.01327645
22modulation by symbiont of host immune response (GO:0052553)4.01327645
23amyloid precursor protein metabolic process (GO:0042982)4.00888772
24oligodendrocyte differentiation (GO:0048709)3.76667249
25protein localization to endosome (GO:0036010)3.73406224
26regulation of collateral sprouting (GO:0048670)3.69183402
27neutrophil activation involved in immune response (GO:0002283)3.64471176
28detection of molecule of bacterial origin (GO:0032490)3.60477872
29negative regulation of neurotransmitter transport (GO:0051589)3.56538063
30response to lipoprotein particle (GO:0055094)3.56158726
31long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.53629552
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.52713659
33macrophage activation involved in immune response (GO:0002281)3.50281657
34amyloid precursor protein catabolic process (GO:0042987)3.49094054
35astrocyte development (GO:0014002)3.48660342
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.46491999
37establishment of mitochondrion localization (GO:0051654)3.44959111
38adhesion of symbiont to host (GO:0044406)3.44003394
39regulation of vitamin D biosynthetic process (GO:0060556)3.42945797
40negative regulation of interleukin-12 production (GO:0032695)3.41683491
41isoprenoid biosynthetic process (GO:0008299)3.39156907
42glycerophospholipid catabolic process (GO:0046475)3.38836604
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38610891
44regulation of interferon-beta biosynthetic process (GO:0045357)3.37615371
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.36248629
46substantia nigra development (GO:0021762)3.36071267
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.29556839
48import into cell (GO:0098657)3.28365486
49long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26566833
50barbed-end actin filament capping (GO:0051016)3.26068649
51regulation of T-helper 2 cell differentiation (GO:0045628)3.19595625
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19080018
53low-density lipoprotein particle clearance (GO:0034383)3.19067328
54response to redox state (GO:0051775)3.16935588
55fibril organization (GO:0097435)3.15561989
56cellular response to type I interferon (GO:0071357)3.15026507
57type I interferon signaling pathway (GO:0060337)3.15026507
58regulation of lipoprotein metabolic process (GO:0050746)3.12246955
59photoreceptor cell differentiation (GO:0046530)3.11681615
60eye photoreceptor cell differentiation (GO:0001754)3.11681615
61L-amino acid import (GO:0043092)3.11623376
62response to type I interferon (GO:0034340)3.11005685
63peptidyl-tyrosine autophosphorylation (GO:0038083)3.10514363
64skin morphogenesis (GO:0043589)3.10473685
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.10125786
66membrane tubulation (GO:0097320)3.05277030
67fatty-acyl-CoA biosynthetic process (GO:0046949)3.05114433
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04619220
69negative regulation of cell killing (GO:0031342)3.04619220
70apical protein localization (GO:0045176)3.04138489
71membrane raft organization (GO:0031579)3.04036836
72type B pancreatic cell proliferation (GO:0044342)3.03610372
73leukocyte migration involved in inflammatory response (GO:0002523)3.03044819
74stress fiber assembly (GO:0043149)2.98267455
75positive regulation of actin filament depolymerization (GO:0030836)2.96061834
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94389101
77asymmetric protein localization (GO:0008105)2.94284253
78extracellular fibril organization (GO:0043206)2.93961867
79protein neddylation (GO:0045116)2.92573722
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.90727854
81detection of other organism (GO:0098543)2.90418732
82regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90371660
83substrate-dependent cell migration (GO:0006929)2.89807879
84glycosylceramide metabolic process (GO:0006677)2.88144891
85fatty-acyl-CoA metabolic process (GO:0035337)2.87907631
86detection of external biotic stimulus (GO:0098581)2.87792615
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84698154
88NIK/NF-kappaB signaling (GO:0038061)2.84024551
89peripheral nervous system axon ensheathment (GO:0032292)2.77471594
90myelination in peripheral nervous system (GO:0022011)2.77471594
91response to methylmercury (GO:0051597)2.75966657
92regulation of vitamin metabolic process (GO:0030656)2.75894320
93positive regulation of interleukin-17 production (GO:0032740)2.75549458
94response to interferon-alpha (GO:0035455)2.75461556
95positive regulation of glial cell differentiation (GO:0045687)2.75395457
96negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75211651
97negative regulation of nitric oxide biosynthetic process (GO:0045019)2.74693222
98nucleotide transmembrane transport (GO:1901679)2.72492071
99antigen processing and presentation of endogenous antigen (GO:0019883)2.72439510
100germinal center formation (GO:0002467)2.70200541
101axon development (GO:0061564)2.68821237
102granulocyte activation (GO:0036230)2.68726490
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68530478
104response to host (GO:0075136)2.68114546
105response to host defenses (GO:0052200)2.68114546
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68114546
107neuron remodeling (GO:0016322)2.66492345
108cell adhesion mediated by integrin (GO:0033627)2.62998429
109presynaptic membrane organization (GO:0097090)2.62108011
110negative regulation of JUN kinase activity (GO:0043508)2.61525029
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.61386602
112pinocytosis (GO:0006907)2.60706815
113peripheral nervous system development (GO:0007422)2.60032910
114protein palmitoylation (GO:0018345)2.58875868
115neutrophil activation (GO:0042119)2.58349875
116negative regulation of acute inflammatory response (GO:0002674)2.57180450
117negative regulation of cytokine production involved in immune response (GO:0002719)2.57113877
118GPI anchor biosynthetic process (GO:0006506)2.56814142
119detection of bacterium (GO:0016045)2.55363993
120regulation of cytokine secretion involved in immune response (GO:0002739)2.54864653
121negative regulation of tumor necrosis factor production (GO:0032720)2.53392527
122response to progesterone (GO:0032570)2.52641007
123response to host immune response (GO:0052572)2.51755831
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51755831
125regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.50968048
126positive regulation of gliogenesis (GO:0014015)2.50327250
127peptidyl-cysteine modification (GO:0018198)2.50220197
128intracellular pH reduction (GO:0051452)2.49525540
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49261267
130positive regulation of action potential (GO:0045760)2.49202793
131regulation of chemokine biosynthetic process (GO:0045073)2.48660326
132tissue regeneration (GO:0042246)2.48418386
133positive regulation of chemokine biosynthetic process (GO:0045080)2.48220331
134magnesium ion transport (GO:0015693)2.47224616
135very long-chain fatty acid metabolic process (GO:0000038)2.46901789
136negative regulation of execution phase of apoptosis (GO:1900118)2.46389205
137regulation of necroptotic process (GO:0060544)2.46372420
138regulation of podosome assembly (GO:0071801)2.45830181
139T-helper 1 type immune response (GO:0042088)2.45177294
140regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.45106944
141modulation by symbiont of host cellular process (GO:0044068)2.45008342
142leukocyte aggregation (GO:0070486)2.44388745
143response to laminar fluid shear stress (GO:0034616)2.44379935
144positive regulation of NF-kappaB import into nucleus (GO:0042346)2.43761694
145negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.42835171
146positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.42830790
147cellular response to virus (GO:0098586)2.42595632
148cellular response to epinephrine stimulus (GO:0071872)2.41592879
149chronic inflammatory response (GO:0002544)2.41549043
150membrane assembly (GO:0071709)2.41526427
151regulation of interferon-alpha production (GO:0032647)2.40951496
152GPI anchor metabolic process (GO:0006505)2.40739328
153protein heterotrimerization (GO:0070208)2.39640320
154detection of biotic stimulus (GO:0009595)2.39399575
155interleukin-6-mediated signaling pathway (GO:0070102)2.39172344
156response to muramyl dipeptide (GO:0032495)2.38617347
157interferon-gamma secretion (GO:0072643)2.37909874
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37609435
159negative regulation of viral entry into host cell (GO:0046597)2.37526088
160positive regulation of T-helper cell differentiation (GO:0045624)2.37433125
161negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37318905
162regulation of T-helper 1 cell differentiation (GO:0045625)2.36801807
163positive regulation of receptor recycling (GO:0001921)2.36499008
164cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35592116
165positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35508181
166thioester biosynthetic process (GO:0035384)2.35351999
167acyl-CoA biosynthetic process (GO:0071616)2.35351999
168regulation of interleukin-6 production (GO:0032675)2.35085492
169hyaluronan catabolic process (GO:0030214)2.34756779
170negative regulation of interleukin-6 production (GO:0032715)2.34732054
171glial cell development (GO:0021782)2.34186888
172cerebral cortex radially oriented cell migration (GO:0021799)2.34125521
173positive regulation of interleukin-8 secretion (GO:2000484)2.33709622
174cell migration involved in heart development (GO:0060973)2.33603232
175nerve growth factor signaling pathway (GO:0038180)2.33412741
176regulation of necrotic cell death (GO:0010939)2.33192699
177positive regulation of interleukin-6 production (GO:0032755)2.33189970
178mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33083009
179regulation of type 2 immune response (GO:0002828)2.33065726
180positive regulation of toll-like receptor signaling pathway (GO:0034123)2.32989730
181pH reduction (GO:0045851)2.32805449
182membrane protein ectodomain proteolysis (GO:0006509)2.32084888
183detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.31698576
184detection of temperature stimulus involved in sensory perception (GO:0050961)2.31698576
185negative regulation of axonogenesis (GO:0050771)2.30673713
186enteric nervous system development (GO:0048484)2.30271880
187amino acid import (GO:0043090)2.30256354
188positive regulation of interferon-alpha production (GO:0032727)2.29782649
189hypotonic response (GO:0006971)2.29038256
190regulation of interleukin-17 production (GO:0032660)2.29000908
191positive regulation of type 2 immune response (GO:0002830)2.28962598
192macrophage activation (GO:0042116)2.28900168
193response to nerve growth factor (GO:1990089)2.27520245
194cellular response to nerve growth factor stimulus (GO:1990090)2.27520245
195presynaptic membrane assembly (GO:0097105)2.26936456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.67823362
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.22154157
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.97035161
4* ELK3_25401928_ChIP-Seq_HUVEC_Human2.92332094
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.63179106
6* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.45002501
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43048064
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40289317
9VDR_21846776_ChIP-Seq_THP-1_Human2.40154907
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34570123
11GBX2_23144817_ChIP-Seq_PC3_Human2.29896408
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.29166084
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.22949050
14LXR_22292898_ChIP-Seq_THP-1_Human2.22195587
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20213791
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15269192
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.06049569
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04223771
19* RACK7_27058665_Chip-Seq_MCF-7_Human2.00742577
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97463768
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95606559
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.93322924
23VDR_24763502_ChIP-Seq_THP-1_Human1.92840475
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91029215
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90936808
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84523784
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79689679
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79178168
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78643094
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78643094
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74497546
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74256583
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69878577
34ER_23166858_ChIP-Seq_MCF-7_Human1.68549625
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67329420
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66227365
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65830391
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65143604
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64065516
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62885765
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.59090097
42TCF7_22412390_ChIP-Seq_EML_Mouse1.58068833
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58039629
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54612962
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54429956
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54339391
47KDM2B_26808549_Chip-Seq_DND41_Human1.54300287
48TAF15_26573619_Chip-Seq_HEK293_Human1.53858176
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52566484
50VDR_22108803_ChIP-Seq_LS180_Human1.51670413
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51471930
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51471930
53MAF_26560356_Chip-Seq_TH1_Human1.51011594
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.50956869
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.50859002
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50353267
57* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49667862
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49200355
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49065047
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47303930
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46444941
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46160639
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45474326
64CLOCK_20551151_ChIP-Seq_293T_Human1.45070288
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.44989448
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44480698
67* ATF3_27146783_Chip-Seq_COLON_Human1.44304748
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.40667862
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.39626453
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38820650
71* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38124089
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.34402326
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.33738033
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33441755
75AR_21572438_ChIP-Seq_LNCaP_Human1.33026528
76ZNF263_19887448_ChIP-Seq_K562_Human1.32309502
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32233472
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30292629
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29479351
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29334137
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28891622
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28891622
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28545500
84TP53_22127205_ChIP-Seq_IMR90_Human1.28534599
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.28422394
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27155274
87SPI1_23127762_ChIP-Seq_K562_Human1.25424284
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24379505
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23825597
90MYC_22102868_ChIP-Seq_BL_Human1.23162242
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22640663
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21970623
93* MAF_26560356_Chip-Seq_TH2_Human1.21344609
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.20212317
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20143754
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19505006
97VDR_24787735_ChIP-Seq_THP-1_Human1.19434616
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18350658
99SPI1_23547873_ChIP-Seq_NB4_Human1.17547724
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17411926
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17010106
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.15509508
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15228447
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15142104
105UTX_26944678_Chip-Seq_JUKART_Human1.14569418
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13774428
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.13397694
108KDM2B_26808549_Chip-Seq_K562_Human1.13170645
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.13026019
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12969007
111SMAD_19615063_ChIP-ChIP_OVARY_Human1.12685590
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12305564
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11727802
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11711842
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10962177
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10363199
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.09808747
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.09654600
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09359575
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09347997
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08716183
122* SOX2_20726797_ChIP-Seq_SW620_Human1.08705997
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08418685
124* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08210126
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07736314
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06899914
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06729885
128ESR2_21235772_ChIP-Seq_MCF-7_Human1.06615890
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.06512878
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06325513
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.06257642
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06028995
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05931347
134CJUN_26792858_Chip-Seq_BT549_Human1.04532466
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04046198
136HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03877999
137EOMES_21245162_ChIP-Seq_HESCs_Human1.03830726
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03678802
139RXR_22158963_ChIP-Seq_LIVER_Mouse1.03142629
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03131957
141P68_20966046_ChIP-Seq_HELA_Human1.01931634
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00902795
143* BCOR_27268052_Chip-Seq_Bcells_Human1.00754153
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00494031
145STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00174444
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99300581
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98629966
148ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98225955
149DROSHA_22980978_ChIP-Seq_HELA_Human0.97239574
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97223922
151TP53_18474530_ChIP-ChIP_U2OS_Human0.94147524
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.92963263
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91435140
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91430953
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90427209
156P300_19829295_ChIP-Seq_ESCs_Human0.89638016
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89554290
158STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89458176
159AHR_22903824_ChIP-Seq_MCF-7_Human0.86811807
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.86526580
161ESR1_20079471_ChIP-ChIP_T-47D_Human0.85229743
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84947705
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.84932195
164JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84341786
165* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83926649
166BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83871923
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.82337838
168SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82098507
169TP53_16413492_ChIP-PET_HCT116_Human0.81594666
170PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80683412
171PRDM14_20953172_ChIP-Seq_ESCs_Human0.78750726
172P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78641779
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.78038713
174JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77576726
175NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76989670
176THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76370729
177NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75376925
178EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75191376
179TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74953015
180OCT4_20526341_ChIP-Seq_ESCs_Human0.73643250
181EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73269028
182TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71970480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.60456357
2MP0003950_abnormal_plasma_membrane3.70382832
3MP0003705_abnormal_hypodermis_morpholog3.48981555
4MP0003690_abnormal_glial_cell3.40411787
5MP0005451_abnormal_body_composition2.93753895
6MP0003880_abnormal_central_pattern2.86339980
7MP0003329_amyloid_beta_deposits2.75219796
8MP0003191_abnormal_cellular_cholesterol2.69304242
9MP0005171_absent_coat_pigmentation2.67220268
10MP0004270_analgesia2.66482110
11MP0006082_CNS_inflammation2.30420555
12MP0006054_spinal_hemorrhage2.30162535
13MP0003634_abnormal_glial_cell2.28885268
14MP0003136_yellow_coat_color2.23337486
15MP0003566_abnormal_cell_adhesion2.18799690
16MP0001542_abnormal_bone_strength2.17585394
17MP0003279_aneurysm2.15635740
18MP0000604_amyloidosis2.15610474
19MP0008438_abnormal_cutaneous_collagen2.13634836
20MP0004742_abnormal_vestibular_system2.11182639
21MP0001905_abnormal_dopamine_level2.03951366
22MP0003724_increased_susceptibility_to2.03716924
23MP0005058_abnormal_lysosome_morphology1.96350239
24MP0003300_gastrointestinal_ulcer1.90057231
25MP0001529_abnormal_vocalization1.88668406
26MP0005023_abnormal_wound_healing1.81131670
27MP0000858_altered_metastatic_potential1.79388694
28MP0008260_abnormal_autophagy1.73905511
29MP0004858_abnormal_nervous_system1.73624989
30MP0003806_abnormal_nucleotide_metabolis1.73004590
31MP0002148_abnormal_hypersensitivity_rea1.71277236
32MP0004510_myositis1.70531258
33MP0004947_skin_inflammation1.69777452
34MP0001485_abnormal_pinna_reflex1.69277654
35MP0005257_abnormal_intraocular_pressure1.68571635
36MP0002272_abnormal_nervous_system1.66889574
37MP0000750_abnormal_muscle_regeneration1.66572870
38MP0002295_abnormal_pulmonary_circulatio1.62836746
39MP0003632_abnormal_nervous_system1.62131759
40MP0003828_pulmonary_edema1.61156366
41MP0004142_abnormal_muscle_tone1.60611609
42MP0004885_abnormal_endolymph1.59610259
43MP0002254_reproductive_system_inflammat1.56516676
44MP0001346_abnormal_lacrimal_gland1.55821586
45MP0009840_abnormal_foam_cell1.55547971
46MP0001835_abnormal_antigen_presentation1.50537991
47MP0001486_abnormal_startle_reflex1.49702512
48MP0005275_abnormal_skin_tensile1.47238147
49MP0009764_decreased_sensitivity_to1.46591172
50MP0005390_skeleton_phenotype1.46498310
51MP0009278_abnormal_bone_marrow1.45709151
52MP0003448_altered_tumor_morphology1.45018667
53MP0003075_altered_response_to1.44916124
54MP0000685_abnormal_immune_system1.41623779
55MP0000767_abnormal_smooth_muscle1.41363961
56MP0002229_neurodegeneration1.40544437
57MP0002064_seizures1.40288834
58MP0009785_altered_susceptibility_to1.38685922
59MP0005410_abnormal_fertilization1.38637589
60MP0000778_abnormal_nervous_system1.32851260
61MP0002419_abnormal_innate_immunity1.32409838
62MP0005623_abnormal_meninges_morphology1.31904640
63MP0001851_eye_inflammation1.31571392
64MP0003195_calcinosis1.29784261
65MP0001849_ear_inflammation1.27949557
66MP0005409_darkened_coat_color1.27924685
67MP0005164_abnormal_response_to1.25882902
68MP0010368_abnormal_lymphatic_system1.25397048
69MP0008004_abnormal_stomach_pH1.23585771
70MP0002452_abnormal_antigen_presenting1.22989307
71MP0002060_abnormal_skin_morphology1.22449764
72MP0002723_abnormal_immune_serum1.22091472
73MP0004043_abnormal_pH_regulation1.20393898
74MP0000751_myopathy1.19679004
75MP0002734_abnormal_mechanical_nocicepti1.19145872
76MP0005408_hypopigmentation1.18702350
77MP0002132_abnormal_respiratory_system1.18388293
78MP0010678_abnormal_skin_adnexa1.17913214
79MP0000383_abnormal_hair_follicle1.17705570
80MP0005167_abnormal_blood-brain_barrier1.17509798
81MP0003631_nervous_system_phenotype1.17218034
82MP0010155_abnormal_intestine_physiology1.13475781
83MP0005503_abnormal_tendon_morphology1.12247484
84MP0005000_abnormal_immune_tolerance1.11523999
85MP0009046_muscle_twitch1.09206761
86MP0008469_abnormal_protein_level1.08748480
87MP0005166_decreased_susceptibility_to1.07984062
88MP0001845_abnormal_inflammatory_respons1.07914963
89MP0005464_abnormal_platelet_physiology1.06261929
90MP0002405_respiratory_system_inflammati1.05839437
91MP0005387_immune_system_phenotype1.04802853
92MP0001790_abnormal_immune_system1.04802853
93MP0001819_abnormal_immune_cell1.04720402
94MP0002877_abnormal_melanocyte_morpholog1.04640950
95MP0001243_abnormal_dermal_layer1.04269752
96MP0001348_abnormal_lacrimal_gland1.03890958
97MP0004272_abnormal_basement_membrane1.03547239
98MP0002420_abnormal_adaptive_immunity1.03509614
99MP0005595_abnormal_vascular_smooth1.01362149
100MP0001958_emphysema1.01291444
101MP0004134_abnormal_chest_morphology1.01183057
102MP0003303_peritoneal_inflammation1.00809175
103MP0001800_abnormal_humoral_immune1.00158764
104MP0004381_abnormal_hair_follicle0.99205188
105MP0000462_abnormal_digestive_system0.98479763
106MP0000343_altered_response_to0.98316658
107MP0003633_abnormal_nervous_system0.97615171
108MP0001533_abnormal_skeleton_physiology0.95680494
109MP0000249_abnormal_blood_vessel0.95016391
110MP0003656_abnormal_erythrocyte_physiolo0.93793734
111MP0005025_abnormal_response_to0.92543178
112MP0010352_gastrointestinal_tract_polyps0.91014614
113MP0002933_joint_inflammation0.90113727
114MP0001440_abnormal_grooming_behavior0.89600543
115MP0001299_abnormal_eye_distance/0.88139360
116MP0003453_abnormal_keratinocyte_physiol0.87936794
117MP0005076_abnormal_cell_differentiation0.87764311
118MP0009333_abnormal_splenocyte_physiolog0.87572515
119MP0004859_abnormal_synaptic_plasticity0.87391019
120MP0000749_muscle_degeneration0.87292736
121MP0002998_abnormal_bone_remodeling0.86719204
122MP0002277_abnormal_respiratory_mucosa0.85784842
123MP0004233_abnormal_muscle_weight0.85175492
124MP0004036_abnormal_muscle_relaxation0.84972425
125MP0005388_respiratory_system_phenotype0.83962168
126MP0002133_abnormal_respiratory_system0.83962168
127MP0009745_abnormal_behavioral_response0.82890735
128MP0005508_abnormal_skeleton_morphology0.82521844
129MP0000747_muscle_weakness0.82329043
130MP0005083_abnormal_biliary_tract0.81135059
131MP0003186_abnormal_redox_activity0.79388788
132MP0003795_abnormal_bone_structure0.79277220
133MP0001853_heart_inflammation0.79063042
134MP0001970_abnormal_pain_threshold0.77770059
135MP0004147_increased_porphyrin_level0.77602263
136MP0000955_abnormal_spinal_cord0.76824535
137MP0005310_abnormal_salivary_gland0.76702007
138MP0002882_abnormal_neuron_morphology0.75696592
139MP0002066_abnormal_motor_capabilities/c0.75690862
140MP0002090_abnormal_vision0.75260476
141MP0004185_abnormal_adipocyte_glucose0.74815583
142MP0005397_hematopoietic_system_phenotyp0.74566629
143MP0001545_abnormal_hematopoietic_system0.74566629
144MP0001963_abnormal_hearing_physiology0.71875703
145MP0005375_adipose_tissue_phenotype0.71717430
146MP0004883_abnormal_blood_vessel0.69480789
147MP0003436_decreased_susceptibility_to0.68905934
148MP0000716_abnormal_immune_system0.66836519
149MP0005195_abnormal_posterior_eye0.65565606
150MP0001663_abnormal_digestive_system0.65325430
151MP0003091_abnormal_cell_migration0.64435573
152MP0000490_abnormal_crypts_of0.64142408
153MP0002896_abnormal_bone_mineralization0.64033438
154MP0000372_irregular_coat_pigmentation0.63987364
155MP0000647_abnormal_sebaceous_gland0.63570368
156MP0002752_abnormal_somatic_nervous0.61473261
157MP0002332_abnormal_exercise_endurance0.60696593
158MP0004924_abnormal_behavior0.60218508
159MP0005386_behavior/neurological_phenoty0.60218508
160MP0005165_increased_susceptibility_to0.59989403

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.86401999
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.84826631
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.84826631
4Parakeratosis (HP:0001036)5.55626667
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.49493278
6Protrusio acetabuli (HP:0003179)4.47318700
7Sensory axonal neuropathy (HP:0003390)4.30994511
8Abnormality of the corticospinal tract (HP:0002492)4.27358653
9Peripheral hypomyelination (HP:0007182)4.20031593
10Cerebral inclusion bodies (HP:0100314)4.05177578
11Onion bulb formation (HP:0003383)3.94614164
12Orchitis (HP:0100796)3.75433630
13Axonal loss (HP:0003447)3.66262798
14Myositis (HP:0100614)3.60049115
15Segmental peripheral demyelination/remyelination (HP:0003481)3.58269837
16Supranuclear gaze palsy (HP:0000605)3.49637916
17Peritonitis (HP:0002586)3.48426080
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.47748703
19Congenital ichthyosiform erythroderma (HP:0007431)3.35475424
20Increased serum pyruvate (HP:0003542)3.31229079
21Abnormality of glycolysis (HP:0004366)3.31229079
22Cerebral hemorrhage (HP:0001342)3.28950376
23Aortic aneurysm (HP:0004942)3.27603009
24Cervical subluxation (HP:0003308)3.20204179
25Muscle fiber splitting (HP:0003555)3.13657968
26Vertebral compression fractures (HP:0002953)3.11020381
27Cerebral hypomyelination (HP:0006808)3.03867499
28Atrophic scars (HP:0001075)3.03506424
29Vascular tortuosity (HP:0004948)3.00204582
30Increased connective tissue (HP:0009025)2.96532564
31Slow saccadic eye movements (HP:0000514)2.88768192
32Retrobulbar optic neuritis (HP:0100654)2.87768801
33Optic neuritis (HP:0100653)2.87768801
34Abnormal auditory evoked potentials (HP:0006958)2.85424847
35Dilatation of the ascending aorta (HP:0005111)2.83973818
36Leukodystrophy (HP:0002415)2.80062946
37Hepatosplenomegaly (HP:0001433)2.79771242
38Elevated erythrocyte sedimentation rate (HP:0003565)2.77761306
39Short nail (HP:0001799)2.73518783
40Akinesia (HP:0002304)2.72555994
41Stridor (HP:0010307)2.72198325
42Abnormality of macrophages (HP:0004311)2.71873296
43Arterial tortuosity (HP:0005116)2.70789706
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.67537245
45Osteolytic defects of the hand bones (HP:0009699)2.67537245
46Aortic dissection (HP:0002647)2.64706511
47Termporal pattern (HP:0011008)2.64532570
48Insidious onset (HP:0003587)2.64532570
49Reduced subcutaneous adipose tissue (HP:0003758)2.62661501
50Spastic gait (HP:0002064)2.62428312
51Blue sclerae (HP:0000592)2.60743716
52Spastic paraparesis (HP:0002313)2.58773522
53Dysmetria (HP:0001310)2.57342884
54Fragile skin (HP:0001030)2.57237026
55Abnormality of glycolipid metabolism (HP:0010969)2.51040478
56Abnormality of liposaccharide metabolism (HP:0010968)2.51040478
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.51040478
58Renal Fanconi syndrome (HP:0001994)2.50753958
59Ankle contracture (HP:0006466)2.48131789
60Clumsiness (HP:0002312)2.46244577
61Intention tremor (HP:0002080)2.44858069
62Alacrima (HP:0000522)2.40500764
63Hyporeflexia of lower limbs (HP:0002600)2.38764388
64Spinal rigidity (HP:0003306)2.38682755
65Pheochromocytoma (HP:0002666)2.37354658
66Stomatitis (HP:0010280)2.35573919
67Thin bony cortex (HP:0002753)2.33204591
68Hypoplasia of the iris (HP:0007676)2.33046544
69Foot dorsiflexor weakness (HP:0009027)2.32390161
70Increased variability in muscle fiber diameter (HP:0003557)2.32343995
71Peripheral demyelination (HP:0011096)2.31793148
72Slender build (HP:0001533)2.30664712
73White forelock (HP:0002211)2.30503406
74Hypoplastic pelvis (HP:0008839)2.29255218
75Genu recurvatum (HP:0002816)2.28589355
76Distal lower limb muscle weakness (HP:0009053)2.27480480
77Recurrent abscess formation (HP:0002722)2.27208702
78Cerebral aneurysm (HP:0004944)2.26648564
79Retinal dysplasia (HP:0007973)2.25622511
80Aplasia involving bones of the upper limbs (HP:0009823)2.25274537
81Aplasia of the phalanges of the hand (HP:0009802)2.25274537
82Aplasia involving bones of the extremities (HP:0009825)2.25274537
83Myocardial infarction (HP:0001658)2.25183088
84Paraparesis (HP:0002385)2.24039504
85Prolonged neonatal jaundice (HP:0006579)2.22229634
86Patchy hypopigmentation of hair (HP:0011365)2.21802092
87Premature rupture of membranes (HP:0001788)2.21348229
88Wormian bones (HP:0002645)2.20229259
89Thickened helices (HP:0000391)2.19804896
90Abnormality of the distal phalanges of the toes (HP:0010182)2.16734309
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.14979357
92Joint stiffness (HP:0001387)2.14950966
93Keratoconjunctivitis sicca (HP:0001097)2.14080956
94Episodic fever (HP:0001954)2.14012644
95Achilles tendon contracture (HP:0001771)2.13864849
96Spondylolisthesis (HP:0003302)2.13426087
97Neuroendocrine neoplasm (HP:0100634)2.12092207
98Premature skin wrinkling (HP:0100678)2.11953989
99Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10328275
100Rough bone trabeculation (HP:0100670)2.09546429
101Myokymia (HP:0002411)2.09183207
102Dysostosis multiplex (HP:0000943)2.08916403
103Hemorrhage of the eye (HP:0011885)2.08306989
104Absent septum pellucidum (HP:0001331)2.08078883
105Distal lower limb amyotrophy (HP:0008944)2.07666882
106Autoamputation (HP:0001218)2.06281435
107Infantile muscular hypotonia (HP:0008947)2.06163376
108Spontaneous hematomas (HP:0007420)2.05877711
109Abnormality of skeletal muscle fiber size (HP:0012084)2.05863782
110Hypertriglyceridemia (HP:0002155)2.04771488
111Spastic tetraparesis (HP:0001285)2.03837302
112Shallow orbits (HP:0000586)2.03402627
113Abnormality of the foot musculature (HP:0001436)2.03239185
114Cellulitis (HP:0100658)2.03009950
115Interstitial pulmonary disease (HP:0006530)2.02954037
116Amyloidosis (HP:0011034)2.02787028
117Difficulty climbing stairs (HP:0003551)2.02114053
118Ankle clonus (HP:0011448)2.01942412
119Generalized amyotrophy (HP:0003700)2.01279796
120Abnormality of polysaccharide metabolism (HP:0011012)2.01136111
121Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01136111
122Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01136111
123Decreased motor nerve conduction velocity (HP:0003431)2.01078285
124Recurrent bacterial skin infections (HP:0005406)2.00918729
125Muscle hypertrophy of the lower extremities (HP:0008968)2.00405012
126Gastrointestinal infarctions (HP:0005244)1.98655367
127Abnormality of the pericardium (HP:0001697)1.98210942
128Upper limb amyotrophy (HP:0009129)1.97101403
129Distal upper limb amyotrophy (HP:0007149)1.97101403
130Soft skin (HP:0000977)1.97050648
131Bladder diverticulum (HP:0000015)1.96360780
132Broad metatarsal (HP:0001783)1.96249768
133Type 1 muscle fiber predominance (HP:0003803)1.95928513
134Gingivitis (HP:0000230)1.95720868
135Acute necrotizing encephalopathy (HP:0006965)1.94850768
136Erythroderma (HP:0001019)1.93325221
137Aneurysm (HP:0002617)1.92591960
138Keratoconjunctivitis (HP:0001096)1.91776660
139Recurrent gram-negative bacterial infections (HP:0005420)1.91131876
140Gowers sign (HP:0003391)1.90382503
141Disproportionate tall stature (HP:0001519)1.90357786
142Increased cerebral lipofuscin (HP:0011813)1.88091493
143Lower limb muscle weakness (HP:0007340)1.87308841
144Loss of speech (HP:0002371)1.86425188
145Split foot (HP:0001839)1.86314195
146Adrenal hypoplasia (HP:0000835)1.85712446
147Broad face (HP:0000283)1.84825065
148Abnormality of the Achilles tendon (HP:0005109)1.84031191
149Metabolic alkalosis (HP:0200114)1.83670506
150Mitral regurgitation (HP:0001653)1.83205112
151Petechiae (HP:0000967)1.82810353
152Methylmalonic acidemia (HP:0002912)1.82723078
153Mucopolysacchariduria (HP:0008155)1.82592208
154Urinary glycosaminoglycan excretion (HP:0003541)1.82592208
155Nuclear cataract (HP:0100018)1.82376680
156Eczematoid dermatitis (HP:0000976)1.82349005
157Emphysema (HP:0002097)1.82200120
158Ectopia lentis (HP:0001083)1.81981005
159Nonimmune hydrops fetalis (HP:0001790)1.81650681
160Purpura (HP:0000979)1.81450762
161Follicular hyperkeratosis (HP:0007502)1.79498572
162Anorexia (HP:0002039)1.78184441
163Increased hepatocellular lipid droplets (HP:0006565)1.77798810
164Ulnar deviation of the wrist (HP:0003049)1.77363300
165Coronal craniosynostosis (HP:0004440)1.77111857
166Elbow flexion contracture (HP:0002987)1.76209962
167Nemaline bodies (HP:0003798)1.75939872
168Decreased lacrimation (HP:0000633)1.74983713
169Joint laxity (HP:0001388)1.74834928
170Mitral valve prolapse (HP:0001634)1.74134111
171Mediastinal lymphadenopathy (HP:0100721)1.74061535
172Easy fatigability (HP:0003388)1.74002664
173Abnormal trabecular bone morphology (HP:0100671)1.73708656
174Recurrent skin infections (HP:0001581)1.73166182
175Hammertoe (HP:0001765)1.72861365
176Polycythemia (HP:0001901)1.71922206
177Thick nail (HP:0001805)1.71334456
178Abnormality of the septum pellucidum (HP:0007375)1.71235791
179Distal sensory impairment (HP:0002936)1.70136938
180Steppage gait (HP:0003376)1.68912923
181Diminished movement (HP:0002374)1.68338499
182Difficulty running (HP:0009046)1.66233005
183Abnormality of the middle phalanges of the toes (HP:0010183)1.64599114
184Scanning speech (HP:0002168)1.63730638
185Morphological abnormality of the inner ear (HP:0011390)1.63518335
186Increased circulating renin level (HP:0000848)1.63245214
187Mitochondrial inheritance (HP:0001427)1.61855142
188Pulmonary artery stenosis (HP:0004415)1.61107836
189Hypophosphatemic rickets (HP:0004912)1.61014491
190Vacuolated lymphocytes (HP:0001922)1.60983624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.82260310
2OXSR14.09775451
3EPHB14.01408829
4ERN13.91703827
5IRAK33.59879858
6PBK3.47430956
7BCR3.08935252
8EPHA22.74224814
9MAP2K32.70612059
10MAP3K32.60220528
11PKN12.54323871
12TESK12.48162327
13TGFBR22.47519658
14LIMK12.44228142
15TAOK22.40627517
16MET2.38221291
17MAP3K112.33213323
18TAOK12.32841113
19WNK42.32470114
20NME22.29886930
21MST42.22276493
22SIK12.21990413
23RIPK12.05019136
24ARAF2.01245651
25CDK191.97973447
26PAK41.96027153
27WNK11.94450683
28MAPKAPK51.93443227
29PRPF4B1.74411192
30PRKD21.71995339
31FGR1.70857751
32EPHB21.66558549
33TYK21.60951437
34TRIB31.55273105
35CSNK1A1L1.49245001
36ROCK21.49236356
37SMG11.48087692
38CSNK1G31.45753216
39TESK21.43971400
40PAK61.40071329
41NEK61.39077477
42MYLK1.37067847
43NTRK11.36942417
44PTK21.33557572
45CAMK2B1.31774931
46LMTK21.31405699
47CAMK2D1.26998140
48MAP4K11.21169941
49CLK11.20964886
50STK101.20168211
51ZAP701.17960279
52SIK31.16757366
53ERBB41.16488186
54MAP3K11.15776968
55MAP3K141.14639858
56RIPK41.14085099
57FGFR21.13652365
58BLK1.13382038
59CSNK1G11.05807738
60PDGFRA1.04359087
61JAK31.03921842
62ICK1.03832038
63PRKG21.03578870
64TRPM71.01945458
65UHMK11.01921556
66CSNK1G21.01891625
67CDC42BPA0.99894480
68DYRK20.99730097
69CAMK2G0.99116058
70TTN0.95836754
71LATS20.95756078
72PTK60.94546022
73PRKCQ0.94087318
74TNIK0.87747517
75PRKD10.85855327
76CASK0.85842162
77GRK60.84733899
78STK380.84221488
79ABL20.83627741
80KSR20.83536656
81MAP3K120.83245799
82PRKCE0.81047280
83IKBKB0.80543787
84SGK2230.80096086
85SGK4940.80096086
86MOS0.79063135
87MAP3K130.78583783
88PAK30.78326414
89TBK10.74520146
90CAMK2A0.74349308
91PDPK10.72974063
92BMPR1B0.71389630
93HIPK20.71354733
94GRK50.70740041
95MST1R0.69627963
96BMX0.69474292
97OBSCN0.67526369
98BMPR20.67374683
99CDK140.67216298
100PIM20.66379665
101CSK0.66014295
102MAP3K80.60216314
103MAP2K20.58519430
104FYN0.58513097
105PAK10.58240461
106HCK0.56446786
107GRK70.55658250
108PIK3CA0.54677187
109PTK2B0.54122331
110CDK50.53718244
111RPS6KA50.53258849
112BRAF0.52925557
113DAPK30.52704552
114MATK0.52165973
115JAK10.51474908
116MARK20.51426358
117CDK150.50167260
118DDR20.49547008
119PHKG20.48027470
120PHKG10.48027470
121PNCK0.47941828
122ADRBK10.47828386
123MAP3K50.47640258
124GSK3A0.47470655
125TIE10.47369824
126IRAK40.47328190
127IRAK20.46929236
128CDK180.45427455
129ABL10.45195120
130ADRBK20.45094168
131TYRO30.44984277
132RPS6KA20.44875501
133LRRK20.44511735
134PRKG10.43213765
135CDK11A0.41266497
136DMPK0.40341439
137MAPKAPK20.39486536
138RPS6KC10.39357163
139RPS6KL10.39357163
140MAP3K60.39284506
141CSNK1A10.39100825
142TNK20.38809871
143JAK20.38279160
144CHUK0.37401710
145MAPK150.37307736
146EPHA40.36961224
147MARK10.36767049
148MAPK70.35960064
149PRKCH0.35749865
150RAF10.35668024
151DYRK1B0.34508170
152IRAK10.33622522
153INSR0.31388984
154CSNK1D0.29968994
155ILK0.29499985
156LCK0.28558793
157PDGFRB0.28219675
158FES0.27708577
159KDR0.27704845
160DYRK30.27642407
161IKBKE0.27183885

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.72448362
2Steroid biosynthesis_Homo sapiens_hsa001004.54854725
3Fatty acid elongation_Homo sapiens_hsa000623.80734229
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.89376164
5Ether lipid metabolism_Homo sapiens_hsa005652.70597916
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65516150
7Oxidative phosphorylation_Homo sapiens_hsa001902.38398499
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27192934
9Sulfur metabolism_Homo sapiens_hsa009202.19845190
10Rheumatoid arthritis_Homo sapiens_hsa053232.10134214
11Legionellosis_Homo sapiens_hsa051341.95566841
12Other glycan degradation_Homo sapiens_hsa005111.87413753
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.87136690
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86567716
15Malaria_Homo sapiens_hsa051441.75065842
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74403029
17Graft-versus-host disease_Homo sapiens_hsa053321.66918487
18Parkinsons disease_Homo sapiens_hsa050121.61092516
19Sphingolipid metabolism_Homo sapiens_hsa006001.57379114
20Bladder cancer_Homo sapiens_hsa052191.56278897
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55413278
22Toxoplasmosis_Homo sapiens_hsa051451.54254839
23Alzheimers disease_Homo sapiens_hsa050101.52616630
24Collecting duct acid secretion_Homo sapiens_hsa049661.52383850
25Histidine metabolism_Homo sapiens_hsa003401.51716109
26Protein export_Homo sapiens_hsa030601.51647614
27Linoleic acid metabolism_Homo sapiens_hsa005911.43917516
28Acute myeloid leukemia_Homo sapiens_hsa052211.41156740
29Phagosome_Homo sapiens_hsa041451.40569560
30Influenza A_Homo sapiens_hsa051641.39738534
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37411683
32Apoptosis_Homo sapiens_hsa042101.31093338
33Focal adhesion_Homo sapiens_hsa045101.30999184
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30477529
35Lysosome_Homo sapiens_hsa041421.30102944
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29960874
37Chronic myeloid leukemia_Homo sapiens_hsa052201.27284223
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26892826
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26453866
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26386007
41Axon guidance_Homo sapiens_hsa043601.24647487
42Allograft rejection_Homo sapiens_hsa053301.24099471
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22454617
44Vibrio cholerae infection_Homo sapiens_hsa051101.22449375
45Autoimmune thyroid disease_Homo sapiens_hsa053201.21282709
46Measles_Homo sapiens_hsa051621.20263527
47Hepatitis B_Homo sapiens_hsa051611.19898748
48Proteoglycans in cancer_Homo sapiens_hsa052051.19381216
49Sulfur relay system_Homo sapiens_hsa041221.16856995
50Galactose metabolism_Homo sapiens_hsa000521.15307300
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15015316
52Pancreatic cancer_Homo sapiens_hsa052121.11460026
53Vitamin B6 metabolism_Homo sapiens_hsa007501.09679393
54Notch signaling pathway_Homo sapiens_hsa043301.07824876
55Viral myocarditis_Homo sapiens_hsa054161.06047733
56Salmonella infection_Homo sapiens_hsa051321.05964706
57Renal cell carcinoma_Homo sapiens_hsa052111.05010700
58Staphylococcus aureus infection_Homo sapiens_hsa051501.02431642
59Pertussis_Homo sapiens_hsa051331.01471049
60Mineral absorption_Homo sapiens_hsa049780.96885333
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.96656796
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96373699
63Asthma_Homo sapiens_hsa053100.96058921
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95483539
65Hematopoietic cell lineage_Homo sapiens_hsa046400.95424675
66Arginine and proline metabolism_Homo sapiens_hsa003300.94630099
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.93650427
68Small cell lung cancer_Homo sapiens_hsa052220.93100766
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91831197
70VEGF signaling pathway_Homo sapiens_hsa043700.88487485
71Arachidonic acid metabolism_Homo sapiens_hsa005900.87775099
72Fructose and mannose metabolism_Homo sapiens_hsa000510.87443944
73Herpes simplex infection_Homo sapiens_hsa051680.86630326
74Butanoate metabolism_Homo sapiens_hsa006500.86250988
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85915559
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.84773935
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82147686
78Pentose phosphate pathway_Homo sapiens_hsa000300.81279256
79B cell receptor signaling pathway_Homo sapiens_hsa046620.81243987
80Cardiac muscle contraction_Homo sapiens_hsa042600.79037706
81African trypanosomiasis_Homo sapiens_hsa051430.78783129
82Huntingtons disease_Homo sapiens_hsa050160.78007919
83Glutathione metabolism_Homo sapiens_hsa004800.77076683
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76633589
85Leishmaniasis_Homo sapiens_hsa051400.75449164
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74680136
87Folate biosynthesis_Homo sapiens_hsa007900.73826983
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.73543627
89Tight junction_Homo sapiens_hsa045300.73227243
90Serotonergic synapse_Homo sapiens_hsa047260.72469250
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72211743
92Endocytosis_Homo sapiens_hsa041440.71444484
93Adherens junction_Homo sapiens_hsa045200.70559517
94HTLV-I infection_Homo sapiens_hsa051660.69599834
95Tuberculosis_Homo sapiens_hsa051520.67724380
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.66660720
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62863242
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62768636
99Prion diseases_Homo sapiens_hsa050200.62711085
100Chemokine signaling pathway_Homo sapiens_hsa040620.62207835
101Insulin resistance_Homo sapiens_hsa049310.60791068
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60771368
103Epstein-Barr virus infection_Homo sapiens_hsa051690.60129620
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59282777
105Shigellosis_Homo sapiens_hsa051310.59261825
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58900756
107Rap1 signaling pathway_Homo sapiens_hsa040150.58655808
108Ras signaling pathway_Homo sapiens_hsa040140.58226849
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57730420
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.57609363
111Pathways in cancer_Homo sapiens_hsa052000.57492265
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56978711
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.56806416
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.56666751
115Complement and coagulation cascades_Homo sapiens_hsa046100.56603246
116Type I diabetes mellitus_Homo sapiens_hsa049400.56188177
117Dorso-ventral axis formation_Homo sapiens_hsa043200.55270087
118Viral carcinogenesis_Homo sapiens_hsa052030.53476354
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53243862
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52806724
121GABAergic synapse_Homo sapiens_hsa047270.52641034
122HIF-1 signaling pathway_Homo sapiens_hsa040660.52111850
123Chemical carcinogenesis_Homo sapiens_hsa052040.51832079
124ECM-receptor interaction_Homo sapiens_hsa045120.51662548
125Non-small cell lung cancer_Homo sapiens_hsa052230.51324499
126Peroxisome_Homo sapiens_hsa041460.51201516
127Fatty acid biosynthesis_Homo sapiens_hsa000610.50550542
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50465529
129Platelet activation_Homo sapiens_hsa046110.50436531
130Amoebiasis_Homo sapiens_hsa051460.49720049
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49371524
132Endometrial cancer_Homo sapiens_hsa052130.47716735
133Vitamin digestion and absorption_Homo sapiens_hsa049770.47388519
134Regulation of autophagy_Homo sapiens_hsa041400.46237386
135Ovarian steroidogenesis_Homo sapiens_hsa049130.46216185
136Prostate cancer_Homo sapiens_hsa052150.45345522
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45199112
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45082855
139MAPK signaling pathway_Homo sapiens_hsa040100.44608749
140Insulin signaling pathway_Homo sapiens_hsa049100.43576963
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43266433
142Fatty acid metabolism_Homo sapiens_hsa012120.43122780
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.42366287
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41801499
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40636120
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.38804244
147Glutamatergic synapse_Homo sapiens_hsa047240.37810546
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37579116
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.35375060
150Hepatitis C_Homo sapiens_hsa051600.35234244
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34621454
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34180813
153TNF signaling pathway_Homo sapiens_hsa046680.33947833
154Osteoclast differentiation_Homo sapiens_hsa043800.33918955
155ErbB signaling pathway_Homo sapiens_hsa040120.33464496
156Long-term depression_Homo sapiens_hsa047300.32641068
157Morphine addiction_Homo sapiens_hsa050320.32229584
158Dilated cardiomyopathy_Homo sapiens_hsa054140.30091375
159Synaptic vesicle cycle_Homo sapiens_hsa047210.29162727
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28758768

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