CDC42EP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)4.73749549
2ribosomal small subunit assembly (GO:0000028)4.54543511
3cilium or flagellum-dependent cell motility (GO:0001539)4.51505075
4piRNA metabolic process (GO:0034587)4.40788153
5axonemal dynein complex assembly (GO:0070286)4.08614332
6viral transcription (GO:0019083)4.01222982
7motile cilium assembly (GO:0044458)3.98192588
8skin morphogenesis (GO:0043589)3.94484319
9translational termination (GO:0006415)3.84891009
10sperm-egg recognition (GO:0035036)3.80148951
11binding of sperm to zona pellucida (GO:0007339)3.74937434
12plasma membrane fusion (GO:0045026)3.60989930
13acrosome assembly (GO:0001675)3.59356521
14substrate-dependent cell migration (GO:0006929)3.54299145
15cell-cell recognition (GO:0009988)3.53753205
16membrane raft organization (GO:0031579)3.50109383
17cell adhesion mediated by integrin (GO:0033627)3.47515605
18ribosomal small subunit biogenesis (GO:0042274)3.43413917
19sequestering of extracellular ligand from receptor (GO:0035581)3.42643339
20translational elongation (GO:0006414)3.34521915
21regulation of necroptotic process (GO:0060544)3.31680086
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30617652
23collagen fibril organization (GO:0030199)3.30163317
24positive regulation by symbiont of host defense response (GO:0052509)3.29149709
25modulation by symbiont of host defense response (GO:0052031)3.29149709
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29149709
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29149709
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.29149709
29modulation by symbiont of host immune response (GO:0052553)3.29149709
30detection of molecule of bacterial origin (GO:0032490)3.28954469
31multicellular organism reproduction (GO:0032504)3.28753503
32negative regulation of phagocytosis (GO:0050765)3.28539683
33sperm motility (GO:0030317)3.27263900
34cellular response to vitamin (GO:0071295)3.21569353
35type B pancreatic cell proliferation (GO:0044342)3.21475435
36protein targeting to ER (GO:0045047)3.19885271
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.19877938
38cotranslational protein targeting to membrane (GO:0006613)3.19084366
39endodermal cell differentiation (GO:0035987)3.17364514
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16591847
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16591847
42cell migration involved in heart development (GO:0060973)3.16013725
43NIK/NF-kappaB signaling (GO:0038061)3.15599303
44hypotonic response (GO:0006971)3.13768843
45DNA deamination (GO:0045006)3.13580351
46definitive hemopoiesis (GO:0060216)3.11721441
47negative regulation of necroptotic process (GO:0060546)3.09375664
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02919366
49acrosome reaction (GO:0007340)3.02505420
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02114318
51pericardium development (GO:0060039)3.01970343
52cellular protein complex disassembly (GO:0043624)3.00066940
53meiotic cell cycle (GO:0051321)2.98732961
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98383816
55protein localization to endoplasmic reticulum (GO:0070972)2.98158389
56viral life cycle (GO:0019058)2.96738273
57stress fiber assembly (GO:0043149)2.94050303
58regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89546476
59cellular response to vitamin D (GO:0071305)2.89536396
60spermatid development (GO:0007286)2.88043504
61negative regulation of cell killing (GO:0031342)2.87220989
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87220989
63positive regulation of fibroblast migration (GO:0010763)2.86777242
64regulation of macrophage cytokine production (GO:0010935)2.86190472
65translational initiation (GO:0006413)2.82843087
66antigen processing and presentation via MHC class Ib (GO:0002475)2.82159004
67antigen processing and presentation of endogenous antigen (GO:0019883)2.81552609
68response to peptidoglycan (GO:0032494)2.81281553
69actin filament depolymerization (GO:0030042)2.76646265
70protein heterotrimerization (GO:0070208)2.76086827
71protein complex disassembly (GO:0043241)2.74863393
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73129761
73maturation of SSU-rRNA (GO:0030490)2.71670092
74synaptonemal complex organization (GO:0070193)2.71412784
75chondrocyte proliferation (GO:0035988)2.71067875
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70277167
77cell wall macromolecule metabolic process (GO:0044036)2.69020107
78cell wall macromolecule catabolic process (GO:0016998)2.69020107
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68894958
80kidney mesenchyme development (GO:0072074)2.68427518
81angiogenesis involved in wound healing (GO:0060055)2.68097155
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65004550
83response to host (GO:0075136)2.65004550
84response to host defenses (GO:0052200)2.65004550
85reproduction (GO:0000003)2.64644578
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62435774
87barbed-end actin filament capping (GO:0051016)2.60929364
88negative regulation of interleukin-12 production (GO:0032695)2.60807503
89protein localization to endosome (GO:0036010)2.60267154
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58665881
91epithelial cilium movement (GO:0003351)2.58561878
92regulation of extracellular matrix disassembly (GO:0010715)2.58056876
93endothelium development (GO:0003158)2.56653202
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55971261
95cellular extravasation (GO:0045123)2.55441724
96macrophage activation involved in immune response (GO:0002281)2.55262908
97mature B cell differentiation involved in immune response (GO:0002313)2.55080390
98macromolecular complex disassembly (GO:0032984)2.53883223
99regulation of interferon-beta biosynthetic process (GO:0045357)2.52850371
100male meiosis (GO:0007140)2.51545350
101extracellular matrix assembly (GO:0085029)2.51532758
102regulation of necrotic cell death (GO:0010939)2.51048434
103sprouting angiogenesis (GO:0002040)2.50363811
104synaptonemal complex assembly (GO:0007130)2.50045516
105positive regulation of gamma-delta T cell activation (GO:0046645)2.48852951
106regulation of cilium movement (GO:0003352)2.47447750
107wound healing, spreading of epidermal cells (GO:0035313)2.46769447
108platelet-derived growth factor receptor signaling pathway (GO:0048008)2.45664495
109regulation of interleukin-8 secretion (GO:2000482)2.45488303
110leukocyte aggregation (GO:0070486)2.44398997
111DNA methylation involved in gamete generation (GO:0043046)2.43938350
112embryonic hemopoiesis (GO:0035162)2.43207851
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41583095
114negative regulation of nitric-oxide synthase activity (GO:0051001)2.38914990
115sequestering of actin monomers (GO:0042989)2.38187340
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37912269
117positive regulation of B cell differentiation (GO:0045579)2.37840756
118fibril organization (GO:0097435)2.37442851
119positive regulation of receptor recycling (GO:0001921)2.37142374
120positive regulation of natural killer cell differentiation (GO:0032825)2.35962918
121positive regulation of macrophage cytokine production (GO:0060907)2.35897878
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35747843
123response to host immune response (GO:0052572)2.35747843
124positive regulation of actin filament depolymerization (GO:0030836)2.35533470
125detection of external biotic stimulus (GO:0098581)2.35227338
126extracellular fibril organization (GO:0043206)2.34857721
127negative regulation of osteoblast proliferation (GO:0033689)2.34633748
128negative regulation of smooth muscle cell migration (GO:0014912)2.34373348
129interferon-gamma secretion (GO:0072643)2.34085676
130positive regulation of interleukin-8 secretion (GO:2000484)2.33741724
131ribosomal large subunit biogenesis (GO:0042273)2.32913797
132mesodermal cell differentiation (GO:0048333)2.32430829
133neutrophil activation involved in immune response (GO:0002283)2.32128775
134translesion synthesis (GO:0019985)2.31586343
135heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.29704582
136telomere maintenance via semi-conservative replication (GO:0032201)2.29421840
137venous blood vessel morphogenesis (GO:0048845)2.29416251
138response to increased oxygen levels (GO:0036296)2.29412010
139response to hyperoxia (GO:0055093)2.29412010
140endocardial cushion development (GO:0003197)2.29202117
141negative regulation of nitric oxide biosynthetic process (GO:0045019)2.28838453
142lymph node development (GO:0048535)2.28737884
143metanephric mesenchyme development (GO:0072075)2.28654025
144activation of MAPKKK activity (GO:0000185)2.28645362
145smooth muscle tissue development (GO:0048745)2.27746952
146cellular response to interferon-alpha (GO:0035457)2.27714807
147negative regulation of necrotic cell death (GO:0060547)2.27572344
148negative regulation of T-helper cell differentiation (GO:0045623)2.27567471
149negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.27567471
150negative regulation of erythrocyte differentiation (GO:0045647)2.26700310
151negative regulation of anoikis (GO:2000811)2.26415036
152heterotypic cell-cell adhesion (GO:0034113)2.26228612
153protein targeting to membrane (GO:0006612)2.26087144
154detection of other organism (GO:0098543)2.25992236
155necroptotic process (GO:0070266)2.25981620
156regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.25414722
157mesenchymal-epithelial cell signaling (GO:0060638)2.24978288
158chromosome organization involved in meiosis (GO:0070192)2.24363041
159regulation of B cell differentiation (GO:0045577)2.24248430
160extracellular regulation of signal transduction (GO:1900115)2.24177221
161extracellular negative regulation of signal transduction (GO:1900116)2.24177221
162regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.23925669
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.23852219
164mature B cell differentiation (GO:0002335)2.23741955
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.23295138
166chondroitin sulfate biosynthetic process (GO:0030206)2.22744004
167meiotic nuclear division (GO:0007126)2.22646558
168plasma membrane repair (GO:0001778)2.22531987
169germ cell migration (GO:0008354)2.22017640
170cellular response to zinc ion (GO:0071294)2.21275670
171T cell homeostasis (GO:0043029)2.20747983
172regulation of type B pancreatic cell apoptotic process (GO:2000674)2.20213873
173myeloid dendritic cell activation (GO:0001773)2.20093332
174wound healing, spreading of cells (GO:0044319)2.19955335
175macrophage differentiation (GO:0030225)2.19948835
176induction of positive chemotaxis (GO:0050930)2.18950129
177pathway-restricted SMAD protein phosphorylation (GO:0060389)2.18942243
178negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.18297287
179cell-substrate junction assembly (GO:0007044)2.17913759
180mRNA catabolic process (GO:0006402)2.17684623
181telomere maintenance via recombination (GO:0000722)2.17556537
182regulation of platelet aggregation (GO:0090330)2.16945297
183neutrophil mediated immunity (GO:0002446)2.15945235
184fibroblast migration (GO:0010761)2.15607760
185platelet dense granule organization (GO:0060155)2.15527633
186megakaryocyte development (GO:0035855)2.13297433
187erythrocyte maturation (GO:0043249)2.12762309
188single fertilization (GO:0007338)2.11697563
189regulation of erythrocyte differentiation (GO:0045646)2.11314634
1903-UTR-mediated mRNA stabilization (GO:0070935)2.11198949
191RNA catabolic process (GO:0006401)2.09659527
192purine deoxyribonucleotide catabolic process (GO:0009155)2.08988521
193morphogenesis of an endothelium (GO:0003159)2.06699095
194endothelial tube morphogenesis (GO:0061154)2.06699095
195dendritic cell differentiation (GO:0097028)2.03304510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.50665058
2SMAD_19615063_ChIP-ChIP_OVARY_Human5.20969021
3E2F7_22180533_ChIP-Seq_HELA_Human3.24795748
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.18023282
5* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93123113
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.91817813
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.82559530
8* BRD4_25478319_ChIP-Seq_HGPS_Human2.80099436
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.55053545
10TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.50167126
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46893098
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46790001
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44931897
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43938729
15CJUN_26792858_Chip-Seq_BT549_Human2.41238393
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37175041
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36401337
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.33326905
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29628818
20SCL_19346495_ChIP-Seq_HPC-7_Human2.28643958
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.28280507
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26924947
23* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.26434615
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.25806575
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23320574
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.22199553
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.16231941
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08053888
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02961069
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98292329
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94230513
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92878928
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92479400
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.92084172
35* EP300_21415370_ChIP-Seq_HL-1_Mouse1.89932352
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89503526
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89152485
38MYB_26560356_Chip-Seq_TH2_Human1.88654529
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87372721
40SPI1_23547873_ChIP-Seq_NB4_Human1.85685435
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.83706079
42* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.83550103
43* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.83550103
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.81280186
45* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81174771
46VDR_23849224_ChIP-Seq_CD4+_Human1.80143827
47* VDR_24787735_ChIP-Seq_THP-1_Human1.79210993
48* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79094741
49* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76799026
50MYC_22102868_ChIP-Seq_BL_Human1.75772004
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.75029566
52MYB_26560356_Chip-Seq_TH1_Human1.73448245
53MAF_26560356_Chip-Seq_TH1_Human1.72549011
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72322249
55* TP53_18474530_ChIP-ChIP_U2OS_Human1.72006233
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71816775
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70034975
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69989515
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69620050
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67248274
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67002313
62* TP53_16413492_ChIP-PET_HCT116_Human1.62741124
63* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60452523
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59609552
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58068207
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56819824
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55245339
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54658885
69* VDR_21846776_ChIP-Seq_THP-1_Human1.53668721
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53384299
71* VDR_24763502_ChIP-Seq_THP-1_Human1.52855867
72ELK1_19687146_ChIP-ChIP_HELA_Human1.52837725
73TCF7_22412390_ChIP-Seq_EML_Mouse1.50991980
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50334647
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48009417
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46784109
77DCP1A_22483619_ChIP-Seq_HELA_Human1.43736432
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43682765
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41371985
80UTX_26944678_Chip-Seq_JUKART_Human1.41126872
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40848352
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40086328
83XRN2_22483619_ChIP-Seq_HELA_Human1.38342508
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37992389
85* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37601043
86* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36558054
87FOXP3_21729870_ChIP-Seq_TREG_Human1.36313478
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35890453
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34544399
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.32269947
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32109391
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31833506
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31765319
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.30212077
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30052938
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29503218
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28868284
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28088093
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26193665
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25207683
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25072441
102* TP63_23658742_ChIP-Seq_EP156T_Human1.24951161
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24163943
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.24018030
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23391409
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22466441
107TTF2_22483619_ChIP-Seq_HELA_Human1.21732053
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21198656
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19665002
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17921104
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17677441
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17187754
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16867362
114* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15969510
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15267280
116RUNX_20019798_ChIP-Seq_JUKART_Human1.12897073
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12346770
118GBX2_23144817_ChIP-Seq_PC3_Human1.12198718
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10365191
120MAF_26560356_Chip-Seq_TH2_Human1.10217108
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.10044492
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10025022
123SPI1_23127762_ChIP-Seq_K562_Human1.09475885
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08932388
125ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08387226
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08193691
127* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07190892
128* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07190892
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.07022575
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06021726
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.05779701
132GABP_19822575_ChIP-Seq_HepG2_Human1.05525789
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04867610
134PU_27001747_Chip-Seq_BMDM_Mouse1.04538025
135E2F1_21310950_ChIP-Seq_MCF-7_Human1.04272850
136* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04086388
137AHR_22903824_ChIP-Seq_MCF-7_Human1.02506341
138* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01543015
139PIAS1_25552417_ChIP-Seq_VCAP_Human1.01182001
140* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00867718
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99965265
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99743581
143* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99334194
144* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99334194
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.96013428
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95696823
147SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95054616
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94253303
149NCOR1_26117541_ChIP-Seq_K562_Human0.94087542
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92942347
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.92696928
152SMAD4_21799915_ChIP-Seq_A2780_Human0.92642332
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92185286
154FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91943067
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91633679
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91552979
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90260271
158GATA3_27048872_Chip-Seq_THYMUS_Human0.89886581
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89537576
160* TP53_22127205_ChIP-Seq_IMR90_Human0.88015365
161* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87780148
162SOX2_20726797_ChIP-Seq_SW620_Human0.87769840
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.86563661
164* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83227853
165* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83095286
166* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82882692
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81094020
168* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80262615
169PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80100134
170CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79468344
171CDX2_22108803_ChIP-Seq_LS180_Human0.79318151
172SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78981234
173UBF1/2_26484160_Chip-Seq_HMECs_Human0.78583979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.20397161
2MP0009379_abnormal_foot_pigmentation2.99163516
3MP0003950_abnormal_plasma_membrane2.96232322
4MP0005410_abnormal_fertilization2.91927674
5MP0004808_abnormal_hematopoietic_stem2.68149980
6MP0002396_abnormal_hematopoietic_system2.60640218
7MP0001545_abnormal_hematopoietic_system2.55333289
8MP0005397_hematopoietic_system_phenotyp2.55333289
9MP0004272_abnormal_basement_membrane2.50343738
10MP0008438_abnormal_cutaneous_collagen2.31864648
11MP0000685_abnormal_immune_system2.22053550
12MP0008007_abnormal_cellular_replicative2.21163196
13MP0003724_increased_susceptibility_to2.16716241
14MP0001835_abnormal_antigen_presentation2.13520223
15MP0003828_pulmonary_edema2.12556185
16MP0009278_abnormal_bone_marrow2.05213202
17MP0005257_abnormal_intraocular_pressure2.01931198
18MP0000569_abnormal_digit_pigmentation1.95858847
19MP0003279_aneurysm1.94289004
20MP0005174_abnormal_tail_pigmentation1.85239833
21MP0009785_altered_susceptibility_to1.80760283
22MP0000749_muscle_degeneration1.80622234
23MP0009384_cardiac_valve_regurgitation1.77701935
24MP0002877_abnormal_melanocyte_morpholog1.77574553
25MP0003436_decreased_susceptibility_to1.76692048
26MP0006054_spinal_hemorrhage1.70988560
27MP0005164_abnormal_response_to1.70730679
28MP0003763_abnormal_thymus_physiology1.69419780
29MP0003303_peritoneal_inflammation1.67393288
30MP0002166_altered_tumor_susceptibility1.65466402
31MP0000013_abnormal_adipose_tissue1.63989893
32MP0002254_reproductive_system_inflammat1.62503491
33MP0001873_stomach_inflammation1.60353836
34MP0000015_abnormal_ear_pigmentation1.60153558
35MP0002398_abnormal_bone_marrow1.58582974
36MP0002295_abnormal_pulmonary_circulatio1.55606163
37MP0003191_abnormal_cellular_cholesterol1.55528830
38MP0002405_respiratory_system_inflammati1.53799104
39MP0010386_abnormal_urinary_bladder1.52679793
40MP0010094_abnormal_chromosome_stability1.52634576
41MP0003045_fibrosis1.51136860
42MP0005671_abnormal_response_to1.50421383
43MP0010352_gastrointestinal_tract_polyps1.47095302
44MP0002420_abnormal_adaptive_immunity1.45496215
45MP0002452_abnormal_antigen_presenting1.45192587
46MP0008057_abnormal_DNA_replication1.44090249
47MP0004883_abnormal_blood_vessel1.43649261
48MP0009780_abnormal_chondrocyte_physiolo1.43318132
49MP0001819_abnormal_immune_cell1.43029275
50MP0001958_emphysema1.42948180
51MP0001800_abnormal_humoral_immune1.42855866
52MP0003786_premature_aging1.41082968
53MP0004084_abnormal_cardiac_muscle1.40040009
54MP0000751_myopathy1.39342184
55MP0006082_CNS_inflammation1.38331695
56MP0001879_abnormal_lymphatic_vessel1.36096191
57MP0002933_joint_inflammation1.34269742
58MP0005000_abnormal_immune_tolerance1.31036938
59MP0002723_abnormal_immune_serum1.30450529
60MP0000689_abnormal_spleen_morphology1.26301502
61MP0000490_abnormal_crypts_of1.25992390
62MP0001929_abnormal_gametogenesis1.25782312
63MP0002095_abnormal_skin_pigmentation1.25022378
64MP0000716_abnormal_immune_system1.24958308
65MP0001790_abnormal_immune_system1.24194432
66MP0005387_immune_system_phenotype1.24194432
67MP0002722_abnormal_immune_system1.24112743
68MP0003566_abnormal_cell_adhesion1.23683684
69MP0005025_abnormal_response_to1.23309270
70MP0002332_abnormal_exercise_endurance1.23273235
71MP0002168_other_aberrant_phenotype1.23162210
72MP0001348_abnormal_lacrimal_gland1.22083874
73MP0002998_abnormal_bone_remodeling1.21998637
74MP0002419_abnormal_innate_immunity1.21429495
75MP0005595_abnormal_vascular_smooth1.18965060
76MP0000733_abnormal_muscle_development1.18337253
77MP0005023_abnormal_wound_healing1.18143728
78MP0000465_gastrointestinal_hemorrhage1.17894519
79MP0002148_abnormal_hypersensitivity_rea1.17529630
80MP0002429_abnormal_blood_cell1.17316615
81MP0001533_abnormal_skeleton_physiology1.16921438
82MP0003091_abnormal_cell_migration1.15951603
83MP0005275_abnormal_skin_tensile1.15104688
84MP0003172_abnormal_lysosome_physiology1.14552444
85MP0000703_abnormal_thymus_morphology1.13901083
86MP0005503_abnormal_tendon_morphology1.12930861
87MP0001188_hyperpigmentation1.11814531
88MP0000858_altered_metastatic_potential1.11767885
89MP0003077_abnormal_cell_cycle1.11429712
90MP0002006_tumorigenesis1.11188794
91MP0002282_abnormal_trachea_morphology1.10785904
92MP0000750_abnormal_muscle_regeneration1.09467763
93MP0001542_abnormal_bone_strength1.09304069
94MP0002896_abnormal_bone_mineralization1.07203916
95MP0008058_abnormal_DNA_repair1.06120069
96MP0000759_abnormal_skeletal_muscle1.05755553
97MP0001853_heart_inflammation1.04433588
98MP0002132_abnormal_respiratory_system1.04093829
99MP0010155_abnormal_intestine_physiology1.03819280
100MP0003111_abnormal_nucleus_morphology1.03335345
101MP0009333_abnormal_splenocyte_physiolog1.01914472
102MP0005409_darkened_coat_color1.01382847
103MP0002210_abnormal_sex_determination1.00066335
104MP0002019_abnormal_tumor_incidence0.99931630
105MP0000767_abnormal_smooth_muscle0.99152208
106MP0002108_abnormal_muscle_morphology0.98337917
107MP0003698_abnormal_male_reproductive0.98312416
108MP0003300_gastrointestinal_ulcer0.98153155
109MP0004036_abnormal_muscle_relaxation0.97691232
110MP0005390_skeleton_phenotype0.97241721
111MP0005464_abnormal_platelet_physiology0.96713374
112MP0000343_altered_response_to0.96163765
113MP0004147_increased_porphyrin_level0.96048687
114MP0003448_altered_tumor_morphology0.94894957
115MP0005508_abnormal_skeleton_morphology0.94516660
116MP0003693_abnormal_embryo_hatching0.93799132
117MP0005620_abnormal_muscle_contractility0.93105742
118MP0005623_abnormal_meninges_morphology0.91009418
119MP0003795_abnormal_bone_structure0.90085531
120MP0004947_skin_inflammation0.89740327
121MP0010368_abnormal_lymphatic_system0.88962697
122MP0001346_abnormal_lacrimal_gland0.86795282
123MP0001299_abnormal_eye_distance/0.84230316
124MP0002060_abnormal_skin_morphology0.83766525
125MP0005165_increased_susceptibility_to0.82763559
126MP0001145_abnormal_male_reproductive0.82188886
127MP0002972_abnormal_cardiac_muscle0.82147660
128MP0002133_abnormal_respiratory_system0.81637616
129MP0005388_respiratory_system_phenotype0.81637616
130MP0000313_abnormal_cell_death0.80280593
131MP0004484_altered_response_of0.79573511
132MP0003075_altered_response_to0.79328159
133MP0004957_abnormal_blastocyst_morpholog0.78903919
134MP0000350_abnormal_cell_proliferation0.77503214
135MP0009053_abnormal_anal_canal0.76110818
136MP0001845_abnormal_inflammatory_respons0.75881215
137MP0004134_abnormal_chest_morphology0.75821769
138MP0004510_myositis0.75377501
139MP0009764_decreased_sensitivity_to0.75023894
140MP0001243_abnormal_dermal_layer0.74424152
141MP0002009_preneoplasia0.73409731
142MP0000249_abnormal_blood_vessel0.71192860
143MP0009250_abnormal_appendicular_skeleto0.70807552
144MP0002128_abnormal_blood_circulation0.70266652
145MP0004087_abnormal_muscle_fiber0.69558074
146MP0005076_abnormal_cell_differentiation0.69057640
147MP0000538_abnormal_urinary_bladder0.68970430
148MP0000534_abnormal_ureter_morphology0.68813261
149MP0002113_abnormal_skeleton_development0.67088662
150MP0000003_abnormal_adipose_tissue0.66984199

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal mucosa (HP:0000433)4.46621546
2Nasal polyposis (HP:0100582)4.45959984
3Spondylolisthesis (HP:0003302)4.41228490
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.36207687
5Absent/shortened dynein arms (HP:0200106)4.36207687
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.30761657
7Vascular tortuosity (HP:0004948)4.24592134
8Arterial tortuosity (HP:0005116)3.93363260
9Premature rupture of membranes (HP:0001788)3.79944616
10Protrusio acetabuli (HP:0003179)3.50499154
11Type 1 muscle fiber predominance (HP:0003803)3.46502107
12Abnormal respiratory epithelium morphology (HP:0012253)3.46206936
13Abnormal respiratory motile cilium morphology (HP:0005938)3.46206936
14Chronic otitis media (HP:0000389)3.34851512
15Follicular hyperkeratosis (HP:0007502)3.34491939
16Thrombocytosis (HP:0001894)3.25169063
17Slender build (HP:0001533)3.12627005
18Toxemia of pregnancy (HP:0100603)3.04696677
19Abnormal respiratory motile cilium physiology (HP:0012261)2.96290050
20Spinal rigidity (HP:0003306)2.86896824
21Increased variability in muscle fiber diameter (HP:0003557)2.82383089
22Rhinitis (HP:0012384)2.79156688
23Mitral stenosis (HP:0001718)2.78860620
24Aortic dissection (HP:0002647)2.77085058
25Abnormal number of erythroid precursors (HP:0012131)2.75281209
26Abnormality of cells of the erythroid lineage (HP:0012130)2.74923230
27Wormian bones (HP:0002645)2.68103452
28Recurrent bronchitis (HP:0002837)2.62585356
29Overgrowth (HP:0001548)2.58703878
30Cardiovascular calcification (HP:0011915)2.55627643
31Aortic aneurysm (HP:0004942)2.54053427
32Bronchitis (HP:0012387)2.53487607
33Myositis (HP:0100614)2.51488179
3411 pairs of ribs (HP:0000878)2.51014713
35Abnormality of skeletal muscle fiber size (HP:0012084)2.50809152
36Reticulocytopenia (HP:0001896)2.50480224
37Mitral valve prolapse (HP:0001634)2.49707372
38Aortic regurgitation (HP:0001659)2.48320491
39Aneurysm (HP:0002617)2.42994729
40Elevated erythrocyte sedimentation rate (HP:0003565)2.40754181
41Chronic bronchitis (HP:0004469)2.39840985
42Blue sclerae (HP:0000592)2.38209808
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.37176844
44Chronic sinusitis (HP:0011109)2.35363319
45Increased density of long bones (HP:0006392)2.27507095
46Aplastic anemia (HP:0001915)2.24341697
47Ankle contracture (HP:0006466)2.23733968
48Cervical subluxation (HP:0003308)2.21315317
49Recurrent abscess formation (HP:0002722)2.20484623
50Muscle fiber atrophy (HP:0100295)2.20359279
51Hematochezia (HP:0002573)2.20288394
52Polygenic inheritance (HP:0010982)2.20243434
53Round ear (HP:0100830)2.19585755
54Peritonitis (HP:0002586)2.19437558
55Atrophic scars (HP:0001075)2.19313060
56Entropion (HP:0000621)2.16190311
57Mitral regurgitation (HP:0001653)2.16008383
58Vertebral compression fractures (HP:0002953)2.15875719
59Striae distensae (HP:0001065)2.15186585
60Aortic valve stenosis (HP:0001650)2.13987408
61Wrist flexion contracture (HP:0001239)2.11950231
62Abnormal ciliary motility (HP:0012262)2.10881796
63Hypoventilation (HP:0002791)2.09122058
64Bradycardia (HP:0001662)2.08932875
65Absent frontal sinuses (HP:0002688)2.07964137
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.07462950
67Osteolytic defects of the hand bones (HP:0009699)2.07462950
68Syringomyelia (HP:0003396)2.03396376
69Spinal cord lesions (HP:0100561)2.03396376
70Hyperextensible skin (HP:0000974)2.03062877
71Retrobulbar optic neuritis (HP:0100654)2.02803227
72Optic neuritis (HP:0100653)2.02803227
73Asymmetric septal hypertrophy (HP:0001670)2.02597823
74Neonatal short-limb short stature (HP:0008921)2.01772251
75Bronchiectasis (HP:0002110)2.01664021
76Delayed gross motor development (HP:0002194)2.01614266
77Joint laxity (HP:0001388)2.01317903
78Type 2 muscle fiber atrophy (HP:0003554)2.00631140
79Dilatation of the ascending aorta (HP:0005111)2.00157760
80Bicuspid aortic valve (HP:0001647)2.00081701
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99743446
82Abnormality of macrophages (HP:0004311)1.99196537
83Ulnar deviation of the wrist (HP:0003049)1.99044908
84Fragile skin (HP:0001030)1.98129898
85Cellulitis (HP:0100658)1.97417067
86Bowel diverticulosis (HP:0005222)1.97348907
87Broad metatarsal (HP:0001783)1.97205622
88Nemaline bodies (HP:0003798)1.96580017
89Recurrent fungal infections (HP:0002841)1.96222243
90Ovoid vertebral bodies (HP:0003300)1.96121827
91Hyporeflexia of lower limbs (HP:0002600)1.95596448
92Bladder diverticulum (HP:0000015)1.95329938
93Radial bowing (HP:0002986)1.94349550
94Pallor (HP:0000980)1.93914226
95Joint stiffness (HP:0001387)1.93204061
96Elbow flexion contracture (HP:0002987)1.91960312
97Cerebral aneurysm (HP:0004944)1.91173734
98Stomatitis (HP:0010280)1.91015368
99Thoracolumbar scoliosis (HP:0002944)1.90991174
100Mildly elevated creatine phosphokinase (HP:0008180)1.90224524
101Facial diplegia (HP:0001349)1.89414354
102Abnormality of the frontal sinuses (HP:0002687)1.88784775
103Soft skin (HP:0000977)1.87183002
104Abnormality of liposaccharide metabolism (HP:0010968)1.86518826
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.86518826
106Abnormality of glycolipid metabolism (HP:0010969)1.86518826
107Petechiae (HP:0000967)1.86408778
108Hyperacusis (HP:0010780)1.84981036
109Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84773974
110Generalized amyotrophy (HP:0003700)1.84689718
111Eczematoid dermatitis (HP:0000976)1.84068973
112Shallow orbits (HP:0000586)1.82796532
113Abnormality of the calf musculature (HP:0001430)1.82153881
114Abnormality of polysaccharide metabolism (HP:0011012)1.79944280
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79944280
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79944280
117Episodic fever (HP:0001954)1.79738657
118Dysostosis multiplex (HP:0000943)1.79002394
119Prolonged bleeding time (HP:0003010)1.78143514
120Delayed closure of the anterior fontanelle (HP:0001476)1.77862528
121Acute myeloid leukemia (HP:0004808)1.77609459
122Infertility (HP:0000789)1.76783823
123Mucopolysacchariduria (HP:0008155)1.76580863
124Urinary glycosaminoglycan excretion (HP:0003541)1.76580863
125Abnormality of the calcaneus (HP:0008364)1.76402752
126Abnormality of skull ossification (HP:0002703)1.75589617
127Mesomelia (HP:0003027)1.74826191
128Muscle fiber inclusion bodies (HP:0100299)1.74268638
129Glucose intolerance (HP:0000833)1.74017292
130Lipoatrophy (HP:0100578)1.74013213
131Beaking of vertebral bodies (HP:0004568)1.73261402
132Biconcave vertebral bodies (HP:0004586)1.72922418
133Long toe (HP:0010511)1.72229053
134Vascular calcification (HP:0004934)1.72196956
135Genu recurvatum (HP:0002816)1.71191672
136Recurrent viral infections (HP:0004429)1.70524536
137Weak cry (HP:0001612)1.69945229
138Reduced subcutaneous adipose tissue (HP:0003758)1.69104816
139Chronic mucocutaneous candidiasis (HP:0002728)1.68399607
140Recurrent cutaneous fungal infections (HP:0011370)1.68399607
141Flat cornea (HP:0007720)1.68255882
142Exertional dyspnea (HP:0002875)1.68037359
143Selective tooth agenesis (HP:0001592)1.67973903
144Calcaneovalgus deformity (HP:0001848)1.67812992
145Short nail (HP:0001799)1.67310954
146Dislocated radial head (HP:0003083)1.66862547
147Myelodysplasia (HP:0002863)1.66725077
148Abnormality of the anterior horn cell (HP:0006802)1.66515680
149Degeneration of anterior horn cells (HP:0002398)1.66515680
150Interstitial pulmonary disease (HP:0006530)1.64839453
151Polycythemia (HP:0001901)1.64665148
152Recurrent sinusitis (HP:0011108)1.64276200
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.63616421
154Increased connective tissue (HP:0009025)1.60779196
155Decreased skull ossification (HP:0004331)1.60526904
156Orchitis (HP:0100796)1.59748589
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.59464228
158Congenital, generalized hypertrichosis (HP:0004540)1.58403818
159Abnormality of dentin (HP:0010299)1.57657727
160Abnormality of the radial head (HP:0003995)1.57232885
161Deformed tarsal bones (HP:0008119)1.57124190
162Spontaneous hematomas (HP:0007420)1.56404588
163Fatigue (HP:0012378)1.56379382
164Abnormality of the acetabulum (HP:0003170)1.55025570
165Areflexia of lower limbs (HP:0002522)1.54967097
166Panhypogammaglobulinemia (HP:0003139)1.54696158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK43.51018620
2PDK33.51018620
3TESK12.97659724
4NME22.82906234
5FRK2.56340805
6PDK22.45089829
7DYRK32.42131925
8LIMK12.40114845
9MUSK2.38706528
10TGFBR22.38593236
11PIM22.32081958
12WEE12.18237317
13EPHB12.15958655
14TTN2.14836150
15TGFBR12.12443935
16MYLK2.06927808
17MAP2K32.06698153
18TEC2.05782152
19KDR2.01108704
20PRKD21.94144301
21STK161.93937928
22TESK21.88836854
23KIT1.87970576
24STK381.84895010
25GRK71.82359987
26PTK21.65105979
27ERN11.61200636
28FLT31.59441886
29PDGFRA1.58397250
30JAK11.54916723
31BTK1.53834328
32RPS6KA41.51850336
33ZAK1.49466348
34TLK11.49391356
35MAP4K11.45829403
36STK101.42901248
37MAP3K31.41041828
38LATS11.35509969
39PAK31.34096137
40NLK1.34092440
41ZAP701.34081802
42VRK11.33795861
43CDC42BPA1.32508206
44TYK21.29273540
45PTK2B1.28906027
46AKT31.27140126
47LRRK21.24591949
48STK38L1.24118621
49FES1.23996883
50IKBKB1.22558941
51ERBB41.18460325
52MAP3K111.17729230
53TBK11.17514970
54BRSK21.14709868
55BUB11.14375566
56TAOK11.13302265
57DMPK1.11734661
58TIE11.10875808
59BLK1.10100949
60NEK21.09058591
61ADRBK11.05055052
62JAK31.04261512
63MAP3K61.03508299
64ROCK11.02054574
65MAPKAPK31.00398790
66ROCK21.00178682
67TRPM70.99128224
68EIF2AK10.98448155
69PDGFRB0.97665175
70RIPK10.95269710
71MAPK70.95053981
72CSF1R0.92571434
73RIPK40.90716688
74SIK10.89398400
75HCK0.88206127
76PIK3CG0.87435746
77IRAK40.86948398
78PINK10.86426920
79TAOK20.85038525
80EEF2K0.84570717
81EIF2AK20.83816138
82BMPR1B0.82259438
83PIM10.77466755
84SYK0.77257390
85MARK30.76873906
86IKBKE0.76618851
87PRKG20.74183790
88YES10.72615441
89PAK40.71279429
90IRAK30.69099181
91KSR10.67394563
92MAP3K140.67038412
93TRIB30.66829981
94CDK80.66739556
95MAPKAPK50.66735570
96MOS0.66456191
97NEK90.66062760
98MELK0.65891499
99FGFR30.65608857
100DYRK1B0.65268611
101DDR20.64854625
102STK240.63992617
103MAP3K10.63891764
104PRKCE0.63612390
105LCK0.62856890
106EPHA30.62854288
107MAP3K70.62296442
108CSK0.61097930
109MAP3K120.60448811
110PKN20.60439767
111MAPKAPK20.58832543
112STK30.58755931
113MAP3K130.58594793
114EPHB20.58243477
115TXK0.57947612
116CDK70.57243387
117ERBB30.55247563
118CDK90.54976014
119PRKD10.54307076
120TRIM280.54282879
121GSK3A0.53788711
122ILK0.53300477
123RPS6KA60.53238137
124CDC70.53116782
125MKNK10.52584035
126ITK0.52024876
127RPS6KC10.51914907
128RPS6KL10.51914907
129SRPK10.50881207
130MAP2K10.49804569
131RPS6KA50.49643792
132IRAK10.49312363
133PIK3CA0.49007197
134HIPK20.48539803
135ABL10.48533099
136PAK20.47983805
137MAPK40.47685155
138ADRBK20.47424921
139PRPF4B0.46587608
140SIK30.46241712
141CLK10.46097605
142MAP3K50.44233749
143CCNB10.44138210
144NUAK10.44106119
145FER0.43530595
146SGK30.43459517
147CAMKK20.43447233
148WNK10.43146974
149RPS6KB20.42178714
150MARK20.41269866
151PLK20.41221866
152RPS6KA20.40978211
153MATK0.40568984
154MAPK150.40310644
155FGR0.40249224
156DAPK30.39930960
157PAK60.39199201
158BCR0.39072692
159GRK60.38643882

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.99178500
2DNA replication_Homo sapiens_hsa030302.52919386
3Homologous recombination_Homo sapiens_hsa034401.81712925
4Leishmaniasis_Homo sapiens_hsa051401.75846949
5Base excision repair_Homo sapiens_hsa034101.73596353
6Antigen processing and presentation_Homo sapiens_hsa046121.71747795
7p53 signaling pathway_Homo sapiens_hsa041151.68446944
8Primary immunodeficiency_Homo sapiens_hsa053401.62472515
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.51776417
10Proteasome_Homo sapiens_hsa030501.49853009
11Shigellosis_Homo sapiens_hsa051311.47040246
12Mismatch repair_Homo sapiens_hsa034301.42658154
13Herpes simplex infection_Homo sapiens_hsa051681.42273069
14Spliceosome_Homo sapiens_hsa030401.41262275
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39868913
16Cell cycle_Homo sapiens_hsa041101.38534148
17Fanconi anemia pathway_Homo sapiens_hsa034601.38312172
18Measles_Homo sapiens_hsa051621.36769075
19Toxoplasmosis_Homo sapiens_hsa051451.36384673
20Basal transcription factors_Homo sapiens_hsa030221.35989549
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.35030095
22B cell receptor signaling pathway_Homo sapiens_hsa046621.34126169
23Viral myocarditis_Homo sapiens_hsa054161.32760716
24Malaria_Homo sapiens_hsa051441.32581085
25Nucleotide excision repair_Homo sapiens_hsa034201.31968797
26Osteoclast differentiation_Homo sapiens_hsa043801.31929376
27Dorso-ventral axis formation_Homo sapiens_hsa043201.29332073
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28593550
29Hematopoietic cell lineage_Homo sapiens_hsa046401.28328733
30Systemic lupus erythematosus_Homo sapiens_hsa053221.27803419
31Legionellosis_Homo sapiens_hsa051341.26375655
32Phagosome_Homo sapiens_hsa041451.26335079
33RNA transport_Homo sapiens_hsa030131.25101495
34Small cell lung cancer_Homo sapiens_hsa052221.21863835
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.19676584
36Apoptosis_Homo sapiens_hsa042101.19642794
37TNF signaling pathway_Homo sapiens_hsa046681.18980805
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18922776
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18240014
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16265581
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14763311
42Epstein-Barr virus infection_Homo sapiens_hsa051691.12586924
43Chronic myeloid leukemia_Homo sapiens_hsa052201.10895224
44Viral carcinogenesis_Homo sapiens_hsa052031.09229026
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09058478
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09049784
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08788774
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07433166
49HTLV-I infection_Homo sapiens_hsa051661.07383848
50Pyrimidine metabolism_Homo sapiens_hsa002401.07332211
51RNA degradation_Homo sapiens_hsa030181.05595032
52Acute myeloid leukemia_Homo sapiens_hsa052211.04196230
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.03721098
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03035009
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02299912
56Focal adhesion_Homo sapiens_hsa045101.02166381
57Melanoma_Homo sapiens_hsa052181.01262613
58ECM-receptor interaction_Homo sapiens_hsa045121.00290249
59Platelet activation_Homo sapiens_hsa046110.99701958
60Adherens junction_Homo sapiens_hsa045200.98464478
61Hepatitis B_Homo sapiens_hsa051610.97040971
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95970157
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92214424
64Renal cell carcinoma_Homo sapiens_hsa052110.92205287
65Thyroid cancer_Homo sapiens_hsa052160.91474350
66RNA polymerase_Homo sapiens_hsa030200.91014120
67Influenza A_Homo sapiens_hsa051640.88588048
68Endocytosis_Homo sapiens_hsa041440.88272106
69FoxO signaling pathway_Homo sapiens_hsa040680.87634293
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85783614
71Pentose phosphate pathway_Homo sapiens_hsa000300.85760486
72Lysosome_Homo sapiens_hsa041420.84758199
73Rap1 signaling pathway_Homo sapiens_hsa040150.83737349
74T cell receptor signaling pathway_Homo sapiens_hsa046600.83695002
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.83582805
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83347891
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82986293
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82563763
79African trypanosomiasis_Homo sapiens_hsa051430.82087380
80MAPK signaling pathway_Homo sapiens_hsa040100.81219091
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.79640375
82Salmonella infection_Homo sapiens_hsa051320.78535779
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77326428
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.77170108
85Allograft rejection_Homo sapiens_hsa053300.77077411
86VEGF signaling pathway_Homo sapiens_hsa043700.77038034
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76605566
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76531039
89Circadian rhythm_Homo sapiens_hsa047100.76214200
90Prostate cancer_Homo sapiens_hsa052150.75200528
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74236369
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.73427159
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72313153
94Pertussis_Homo sapiens_hsa051330.72147059
95Non-small cell lung cancer_Homo sapiens_hsa052230.71300246
96Non-homologous end-joining_Homo sapiens_hsa034500.70872792
97Endometrial cancer_Homo sapiens_hsa052130.70771797
98Prolactin signaling pathway_Homo sapiens_hsa049170.70703024
99Glioma_Homo sapiens_hsa052140.70487651
100Hepatitis C_Homo sapiens_hsa051600.70323288
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69161773
102mRNA surveillance pathway_Homo sapiens_hsa030150.68488650
103GnRH signaling pathway_Homo sapiens_hsa049120.67425862
104Gap junction_Homo sapiens_hsa045400.67021174
105mTOR signaling pathway_Homo sapiens_hsa041500.66448095
106Graft-versus-host disease_Homo sapiens_hsa053320.66103248
107TGF-beta signaling pathway_Homo sapiens_hsa043500.65940755
108Tuberculosis_Homo sapiens_hsa051520.65772226
109Purine metabolism_Homo sapiens_hsa002300.65732436
110Protein export_Homo sapiens_hsa030600.65000227
111Bladder cancer_Homo sapiens_hsa052190.64757359
112MicroRNAs in cancer_Homo sapiens_hsa052060.64386310
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63792208
114Ras signaling pathway_Homo sapiens_hsa040140.63765506
115N-Glycan biosynthesis_Homo sapiens_hsa005100.63274034
116Proteoglycans in cancer_Homo sapiens_hsa052050.62323388
117Insulin resistance_Homo sapiens_hsa049310.62217816
118Renin secretion_Homo sapiens_hsa049240.61713798
119Oxytocin signaling pathway_Homo sapiens_hsa049210.61110593
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59870036
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59071499
122HIF-1 signaling pathway_Homo sapiens_hsa040660.58569504
123Pathways in cancer_Homo sapiens_hsa052000.58552689
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57665149
125Alcoholism_Homo sapiens_hsa050340.57284177
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55962802
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55906959
128Rheumatoid arthritis_Homo sapiens_hsa053230.55767304
129Vibrio cholerae infection_Homo sapiens_hsa051100.54885587
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54499802
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52770717
132Colorectal cancer_Homo sapiens_hsa052100.52257356
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51163621
134Pancreatic cancer_Homo sapiens_hsa052120.51052276
135Amoebiasis_Homo sapiens_hsa051460.49366455
136Chemokine signaling pathway_Homo sapiens_hsa040620.48864465
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48846733
138Dilated cardiomyopathy_Homo sapiens_hsa054140.47598872
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.45913655
140Other glycan degradation_Homo sapiens_hsa005110.44952854
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43815639

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