CDC42EP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.14824269
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.58773499
3sulfur amino acid catabolic process (GO:0000098)4.23596367
4negative regulation of fibrinolysis (GO:0051918)3.98571009
5sodium ion export (GO:0071436)3.96310911
6midgut development (GO:0007494)3.94919861
7reverse cholesterol transport (GO:0043691)3.87844295
8positive regulation of fatty acid beta-oxidation (GO:0032000)3.83374838
9L-phenylalanine metabolic process (GO:0006558)3.82360475
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82360475
11high-density lipoprotein particle remodeling (GO:0034375)3.79633384
12regulation of cholesterol homeostasis (GO:2000188)3.78047815
13L-phenylalanine catabolic process (GO:0006559)3.71000101
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71000101
15low-density lipoprotein particle clearance (GO:0034383)3.65703976
16serine family amino acid catabolic process (GO:0009071)3.64172716
17regulation of protein activation cascade (GO:2000257)3.56243300
18regulation of fibrinolysis (GO:0051917)3.52667119
19amino-acid betaine metabolic process (GO:0006577)3.52270851
20cysteine metabolic process (GO:0006534)3.51832566
21urea cycle (GO:0000050)3.50922556
22urea metabolic process (GO:0019627)3.50922556
23epithelial cell differentiation involved in prostate gland development (GO:0060742)3.50328795
24plasma lipoprotein particle clearance (GO:0034381)3.49845203
25protein carboxylation (GO:0018214)3.49293291
26peptidyl-glutamic acid carboxylation (GO:0017187)3.49293291
27cellular potassium ion homeostasis (GO:0030007)3.48140692
28regulation of fatty acid beta-oxidation (GO:0031998)3.48071251
29complement activation, alternative pathway (GO:0006957)3.44919123
30glyoxylate metabolic process (GO:0046487)3.44403736
31regulation of complement activation (GO:0030449)3.43665023
32lung epithelium development (GO:0060428)3.43536229
33homocysteine metabolic process (GO:0050667)3.34892394
34linoleic acid metabolic process (GO:0043651)3.32030858
35negative regulation of sterol transport (GO:0032372)3.29214065
36negative regulation of cholesterol transport (GO:0032375)3.29214065
37plasma lipoprotein particle remodeling (GO:0034369)3.28179097
38protein-lipid complex remodeling (GO:0034368)3.28179097
39macromolecular complex remodeling (GO:0034367)3.28179097
40bile acid biosynthetic process (GO:0006699)3.27872078
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.26421758
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.22817008
43cellular response to cholesterol (GO:0071397)3.21298664
44positive regulation of triglyceride biosynthetic process (GO:0010867)3.19649217
45lysine catabolic process (GO:0006554)3.18668209
46lysine metabolic process (GO:0006553)3.18668209
47positive regulation of triglyceride metabolic process (GO:0090208)3.17199998
48glycine metabolic process (GO:0006544)3.15241651
49axon extension involved in axon guidance (GO:0048846)3.14651571
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.14651571
51aromatic amino acid family catabolic process (GO:0009074)3.13327663
52regulation of triglyceride catabolic process (GO:0010896)3.10902913
53positive regulation of lipid catabolic process (GO:0050996)3.09229166
54kynurenine metabolic process (GO:0070189)3.08911172
55nitrogen cycle metabolic process (GO:0071941)3.08031642
56acylglycerol homeostasis (GO:0055090)3.05751014
57triglyceride homeostasis (GO:0070328)3.05751014
58positive regulation of fatty acid oxidation (GO:0046321)3.04835939
59regulation of cholesterol esterification (GO:0010872)3.04718858
60gap junction assembly (GO:0016264)3.04682675
61ethanol oxidation (GO:0006069)3.04186044
62postsynaptic membrane organization (GO:0001941)2.99257438
63phospholipid efflux (GO:0033700)2.96668118
64carnitine metabolic process (GO:0009437)2.95568365
65plasma lipoprotein particle assembly (GO:0034377)2.95500176
66regulation of cholesterol storage (GO:0010885)2.92841624
67layer formation in cerebral cortex (GO:0021819)2.92640836
68arginine metabolic process (GO:0006525)2.91931643
69negative regulation of catenin import into nucleus (GO:0035414)2.91226199
70cellular modified amino acid catabolic process (GO:0042219)2.87858168
71serine family amino acid metabolic process (GO:0009069)2.87750893
72semaphorin-plexin signaling pathway (GO:0071526)2.85983252
73synaptic vesicle docking involved in exocytosis (GO:0016081)2.84501795
74apoptotic cell clearance (GO:0043277)2.82395111
75astrocyte differentiation (GO:0048708)2.82075249
76alpha-amino acid catabolic process (GO:1901606)2.82062200
77protein retention in ER lumen (GO:0006621)2.81832284
78lipoprotein metabolic process (GO:0042157)2.81644028
79paraxial mesoderm development (GO:0048339)2.81461188
80bile acid metabolic process (GO:0008206)2.80149224
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79090761
82cellular sodium ion homeostasis (GO:0006883)2.77419083
83cerebellar granule cell differentiation (GO:0021707)2.76917451
84neuronal ion channel clustering (GO:0045161)2.76678647
85neuron projection regeneration (GO:0031102)2.75388775
86low-density lipoprotein particle remodeling (GO:0034374)2.74925390
87phospholipid homeostasis (GO:0055091)2.73410464
88serine family amino acid biosynthetic process (GO:0009070)2.72891921
89desmosome organization (GO:0002934)2.70743899
90indole-containing compound catabolic process (GO:0042436)2.70370122
91indolalkylamine catabolic process (GO:0046218)2.70370122
92tryptophan catabolic process (GO:0006569)2.70370122
93glutamate secretion (GO:0014047)2.70031521
94cholesterol efflux (GO:0033344)2.69913521
95cellular amino acid catabolic process (GO:0009063)2.69737856
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69436374
97G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69123731
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69078822
99COPI coating of Golgi vesicle (GO:0048205)2.68954218
100Golgi transport vesicle coating (GO:0048200)2.68954218
101amino acid import (GO:0043090)2.68136684
102fibrinolysis (GO:0042730)2.68134663
103plasma lipoprotein particle organization (GO:0071827)2.68109135
104cGMP-mediated signaling (GO:0019934)2.67753021
105regulation of cholesterol biosynthetic process (GO:0045540)2.66419958
106regulation of triglyceride biosynthetic process (GO:0010866)2.63676587
107cellular response to sterol (GO:0036315)2.63663747
108aspartate family amino acid catabolic process (GO:0009068)2.62293375
109protein-lipid complex assembly (GO:0065005)2.62156356
110cholesterol homeostasis (GO:0042632)2.61425166
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60994366
112positive regulation of triglyceride lipase activity (GO:0061365)2.60630995
113positive regulation of lipoprotein lipase activity (GO:0051006)2.60630995
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60582568
115central nervous system myelination (GO:0022010)2.60408780
116axon ensheathment in central nervous system (GO:0032291)2.60408780
117glutamate metabolic process (GO:0006536)2.60373810
118epoxygenase P450 pathway (GO:0019373)2.60081073
119regulation of hippo signaling (GO:0035330)2.58894370
120embryonic foregut morphogenesis (GO:0048617)2.58727988
121establishment of apical/basal cell polarity (GO:0035089)2.58164083
122camera-type eye morphogenesis (GO:0048593)2.57737669
123tryptophan metabolic process (GO:0006568)2.57395798
124cell-cell junction maintenance (GO:0045217)2.57237979
125sterol homeostasis (GO:0055092)2.56353266
126cell communication by electrical coupling (GO:0010644)2.56165226
127pyrimidine nucleobase catabolic process (GO:0006208)2.56016299
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.55819113
129endothelial cell chemotaxis (GO:0035767)2.54201580
130axonal fasciculation (GO:0007413)2.53658483
131barbed-end actin filament capping (GO:0051016)2.53010852
132cell migration in hindbrain (GO:0021535)2.48887640
133regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48243249
134positive regulation of synapse maturation (GO:0090129)2.45458471
135potassium ion homeostasis (GO:0055075)2.45127136
136synaptic vesicle exocytosis (GO:0016079)2.44259403
137dendritic spine organization (GO:0097061)2.40064810
138peripheral nervous system axon ensheathment (GO:0032292)2.39530412
139myelination in peripheral nervous system (GO:0022011)2.39530412
140vocalization behavior (GO:0071625)2.38784175
141hemidesmosome assembly (GO:0031581)2.37677861
142auditory behavior (GO:0031223)2.35410743
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34728401
144dendritic spine morphogenesis (GO:0060997)2.32643369
145positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32197701
146lens morphogenesis in camera-type eye (GO:0002089)2.32097213
147apical protein localization (GO:0045176)2.31174999
148growth hormone secretion (GO:0030252)2.30553753
149response to auditory stimulus (GO:0010996)2.30095490
150neuron recognition (GO:0008038)2.23406276
151synaptic vesicle endocytosis (GO:0048488)2.23304929
152astrocyte development (GO:0014002)2.22791816
153synaptic vesicle maturation (GO:0016188)2.20119542
154asymmetric protein localization (GO:0008105)2.20057763
155positive regulation of p38MAPK cascade (GO:1900745)2.20007738
156regulation of p38MAPK cascade (GO:1900744)2.20007358
157cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.19755318
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.18698529
159locomotory exploration behavior (GO:0035641)2.17790618
160axon extension (GO:0048675)2.17262731
161Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.17256224
162axon regeneration (GO:0031103)2.17097014
163lens fiber cell development (GO:0070307)2.16840786
164protein heterotrimerization (GO:0070208)2.15322290
165extracellular matrix assembly (GO:0085029)2.14804215
166cell communication involved in cardiac conduction (GO:0086065)2.14236736
167neurotransmitter-gated ion channel clustering (GO:0072578)2.14231047
168skeletal muscle organ development (GO:0060538)2.13000783
169adherens junction assembly (GO:0034333)2.11988803
170cell junction maintenance (GO:0034331)2.10918377
171cellular response to nitric oxide (GO:0071732)2.10791921
172activation of MAPKKK activity (GO:0000185)2.10070193
173regulation of establishment of planar polarity (GO:0090175)2.09498487
174protein targeting to plasma membrane (GO:0072661)2.08624851
175cerebellar Purkinje cell layer development (GO:0021680)2.08020599
176cell volume homeostasis (GO:0006884)2.08014875
177cellular response to catecholamine stimulus (GO:0071870)2.07544911
178cellular response to monoamine stimulus (GO:0071868)2.07544911
179atrioventricular valve morphogenesis (GO:0003181)2.07059711
180oligodendrocyte differentiation (GO:0048709)2.05801555
181regulation of synaptic vesicle exocytosis (GO:2000300)2.05333524
182L-amino acid import (GO:0043092)2.05278650
183regulation of cholesterol metabolic process (GO:0090181)2.05211806
184regulation of axon extension involved in axon guidance (GO:0048841)2.03681210
185basement membrane organization (GO:0071711)2.03147532
186chondroitin sulfate catabolic process (GO:0030207)2.03131655
187vascular endothelial growth factor signaling pathway (GO:0038084)2.01528220
188regulation of extracellular matrix disassembly (GO:0010715)2.01426618
189presynaptic membrane assembly (GO:0097105)2.01078061
190calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.00753048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.57261036
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80721718
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.70058530
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22589986
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.80490402
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.65090217
7CLOCK_20551151_ChIP-Seq_293T_Human3.31507964
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15897488
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49371076
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48797955
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38302311
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.27853534
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19895650
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17183877
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.16830931
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15163832
17EZH2_22144423_ChIP-Seq_EOC_Human2.13053461
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.12470816
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04103054
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01150605
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01150605
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96426145
23ZNF263_19887448_ChIP-Seq_K562_Human1.96167237
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.90412914
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87033117
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85908534
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84828607
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80235875
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80148065
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76685407
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75899759
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75503663
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75401507
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74840377
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72695025
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.72415283
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.68956952
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68859594
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68270658
40LXR_22292898_ChIP-Seq_THP-1_Human1.67840011
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67718882
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67678668
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.66423916
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.65320861
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62316070
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60308503
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.55907870
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54464335
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53479739
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.51349949
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49224633
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47462968
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46993011
54* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46179461
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46006245
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.45862544
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45452172
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44914981
59* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.44829868
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44244992
61RACK7_27058665_Chip-Seq_MCF-7_Human1.43266378
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42642564
63DROSHA_22980978_ChIP-Seq_HELA_Human1.40018025
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39113732
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37059019
66* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35826484
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.35087942
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34255759
69CTCF_27219007_Chip-Seq_Bcells_Human1.32461612
70* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32160576
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.31359120
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30363790
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30360758
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30196171
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29702052
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28650317
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28039234
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28018599
79KDM2B_26808549_Chip-Seq_K562_Human1.26222776
80* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26182696
81* SMC4_20622854_ChIP-Seq_HELA_Human1.24471887
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22742572
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.22020191
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21718620
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20898748
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20575480
87* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18358110
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15222640
89AR_21909140_ChIP-Seq_LNCAP_Human1.14835019
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14347902
91ATF3_27146783_Chip-Seq_COLON_Human1.13420026
92* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13132197
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12988592
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10996637
95* FOXO3_23340844_ChIP-Seq_DLD1_Human1.10632374
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10540630
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10161503
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09777721
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09432736
100TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07809186
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07147660
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06713907
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.06621134
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.05441459
105* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05381469
106POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04417035
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04199070
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04199070
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04199070
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03730422
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02704764
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02644597
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.02504194
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.02239739
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01522295
116* CREB1_26743006_Chip-Seq_LNCaP_Human1.00867694
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00508627
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00402417
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99837380
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.99277680
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98386725
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96848866
123* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96098268
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.95950632
125KDM2B_26808549_Chip-Seq_DND41_Human0.95763412
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94775453
127* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94145457
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.94051621
129* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93667287
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93102044
131* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92869796
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92330820
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.90888397
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89899276
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89306659
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89080162
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87050012
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.85611202
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.85611202
140* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85083489
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.84917060
142* GATA1_19941826_ChIP-Seq_K562_Human0.84651561
143* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84321936
144* GATA6_25053715_ChIP-Seq_YYC3_Human0.84281855
145NCOR1_26117541_ChIP-Seq_K562_Human0.84280718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.90839990
2MP0005360_urolithiasis4.25449870
3MP0003705_abnormal_hypodermis_morpholog4.07962657
4MP0005365_abnormal_bile_salt3.54809519
5MP0005085_abnormal_gallbladder_physiolo3.08686376
6MP0009840_abnormal_foam_cell3.06959923
7MP0010030_abnormal_orbit_morphology2.88525944
8MP0004859_abnormal_synaptic_plasticity2.87848400
9MP0010329_abnormal_lipoprotein_level2.76116520
10MP0008875_abnormal_xenobiotic_pharmacok2.59888682
11MP0005423_abnormal_somatic_nervous2.53604121
12MP0002254_reproductive_system_inflammat2.50226024
13MP0005083_abnormal_biliary_tract2.47049592
14MP0000566_synostosis2.37041296
15MP0010368_abnormal_lymphatic_system2.31747698
16MP0009053_abnormal_anal_canal2.26427007
17MP0003329_amyloid_beta_deposits2.17204723
18MP0004270_analgesia2.11806470
19MP0003806_abnormal_nucleotide_metabolis1.96468764
20MP0000751_myopathy1.94864746
21MP0000778_abnormal_nervous_system1.91297111
22MP0004272_abnormal_basement_membrane1.88485082
23MP0000537_abnormal_urethra_morphology1.85810307
24MP0008438_abnormal_cutaneous_collagen1.85305698
25MP0003191_abnormal_cellular_cholesterol1.83995998
26MP0003880_abnormal_central_pattern1.83864827
27MP0005167_abnormal_blood-brain_barrier1.81758759
28MP0003252_abnormal_bile_duct1.70964454
29MP0002653_abnormal_ependyma_morphology1.68998432
30MP0005248_abnormal_Harderian_gland1.58838401
31MP0005332_abnormal_amino_acid1.56902107
32MP0005409_darkened_coat_color1.55874857
33MP0001958_emphysema1.55036246
34MP0001502_abnormal_circadian_rhythm1.54597884
35MP0005670_abnormal_white_adipose1.50606071
36MP0003011_delayed_dark_adaptation1.49509179
37MP0000762_abnormal_tongue_morphology1.47319594
38MP0010234_abnormal_vibrissa_follicle1.46953148
39MP0003634_abnormal_glial_cell1.44475786
40MP0000609_abnormal_liver_physiology1.42136570
41MP0004858_abnormal_nervous_system1.41797715
42MP0006054_spinal_hemorrhage1.41628194
43MP0004019_abnormal_vitamin_homeostasis1.41252961
44MP0003115_abnormal_respiratory_system1.40854498
45MP0003635_abnormal_synaptic_transmissio1.40362362
46MP0002796_impaired_skin_barrier1.39669787
47MP0002249_abnormal_larynx_morphology1.35615525
48MP0002118_abnormal_lipid_homeostasis1.31272243
49MP0003879_abnormal_hair_cell1.31238277
50MP0001666_abnormal_nutrient_absorption1.31129432
51MP0002282_abnormal_trachea_morphology1.29203298
52MP0003279_aneurysm1.27024040
53MP0005275_abnormal_skin_tensile1.25935872
54MP0003566_abnormal_cell_adhesion1.25557074
55MP0002063_abnormal_learning/memory/cond1.25545677
56MP0000462_abnormal_digestive_system1.25209090
57MP0004885_abnormal_endolymph1.24726539
58MP0005503_abnormal_tendon_morphology1.21279622
59MP0003690_abnormal_glial_cell1.20860619
60MP0005076_abnormal_cell_differentiation1.18892191
61MP0001879_abnormal_lymphatic_vessel1.18378892
62MP0005171_absent_coat_pigmentation1.17263486
63MP0006138_congestive_heart_failure1.17003177
64MP0002909_abnormal_adrenal_gland1.16036129
65MP0005666_abnormal_adipose_tissue1.14863378
66MP0002064_seizures1.11535471
67MP0009384_cardiac_valve_regurgitation1.10122417
68MP0002896_abnormal_bone_mineralization1.09994701
69MP0003091_abnormal_cell_migration1.09987226
70MP0005187_abnormal_penis_morphology1.07885735
71MP0009379_abnormal_foot_pigmentation1.07183161
72MP0004130_abnormal_muscle_cell1.06197129
73MP0005319_abnormal_enzyme/_coenzyme1.04995059
74MP0005023_abnormal_wound_healing1.04476343
75MP0002734_abnormal_mechanical_nocicepti1.03158141
76MP0001346_abnormal_lacrimal_gland1.02644822
77MP0000647_abnormal_sebaceous_gland1.02298832
78MP0004883_abnormal_blood_vessel1.01006466
79MP0002138_abnormal_hepatobiliary_system0.99910445
80MP0005257_abnormal_intraocular_pressure0.99362634
81MP0009278_abnormal_bone_marrow0.99105295
82MP0000003_abnormal_adipose_tissue0.98736451
83MP0002572_abnormal_emotion/affect_behav0.97976196
84MP0001915_intracranial_hemorrhage0.97681127
85MP0001299_abnormal_eye_distance/0.97193952
86MP0001849_ear_inflammation0.96991851
87MP0003938_abnormal_ear_development0.96815223
88MP0000026_abnormal_inner_ear0.96366909
89MP0001984_abnormal_olfaction0.96278981
90MP0003119_abnormal_digestive_system0.96075816
91MP0004185_abnormal_adipocyte_glucose0.95354044
92MP0000767_abnormal_smooth_muscle0.94017176
93MP0003656_abnormal_erythrocyte_physiolo0.92604927
94MP0000955_abnormal_spinal_cord0.90410541
95MP0002152_abnormal_brain_morphology0.87119408
96MP0003186_abnormal_redox_activity0.86134599
97MP0002295_abnormal_pulmonary_circulatio0.85490121
98MP0002822_catalepsy0.85251809
99MP0002882_abnormal_neuron_morphology0.85173727
100MP0003942_abnormal_urinary_system0.84831867
101MP0005501_abnormal_skin_physiology0.84166987
102MP0001486_abnormal_startle_reflex0.83462214
103MP0003453_abnormal_keratinocyte_physiol0.82972536
104MP0002557_abnormal_social/conspecific_i0.82969579
105MP0002092_abnormal_eye_morphology0.82815651
106MP0002098_abnormal_vibrissa_morphology0.82357650
107MP0005164_abnormal_response_to0.81484139
108MP0000920_abnormal_myelination0.80931450
109MP0000598_abnormal_liver_morphology0.80505150
110MP0003300_gastrointestinal_ulcer0.80171848
111MP0003861_abnormal_nervous_system0.79392065
112MP0002971_abnormal_brown_adipose0.79174695
113MP0004811_abnormal_neuron_physiology0.79014649
114MP0002089_abnormal_postnatal_growth/wei0.79008550
115MP0003075_altered_response_to0.78219858
116MP0005595_abnormal_vascular_smooth0.77979289
117MP0004782_abnormal_surfactant_physiolog0.77304783
118MP0008569_lethality_at_weaning0.77233973
119MP0000049_abnormal_middle_ear0.77161487
120MP0005375_adipose_tissue_phenotype0.77158389
121MP0008961_abnormal_basal_metabolism0.76538318
122MP0000428_abnormal_craniofacial_morphol0.75952123
123MP0002272_abnormal_nervous_system0.75765760
124MP0003385_abnormal_body_wall0.75729964
125MP0000534_abnormal_ureter_morphology0.75545013
126MP0002116_abnormal_craniofacial_bone0.75030565
127MP0002060_abnormal_skin_morphology0.74879525
128MP0002108_abnormal_muscle_morphology0.74642223
129MP0005508_abnormal_skeleton_morphology0.73842959
130MP0000467_abnormal_esophagus_morphology0.73100564
131MP0002638_abnormal_pupillary_reflex0.72493500
132MP0000604_amyloidosis0.72382264
133MP0010352_gastrointestinal_tract_polyps0.72328875
134MP0001614_abnormal_blood_vessel0.71754929
135MP0001177_atelectasis0.71138551
136MP0005499_abnormal_olfactory_system0.70146994
137MP0005394_taste/olfaction_phenotype0.70146994
138MP0002932_abnormal_joint_morphology0.69936847
139MP0006276_abnormal_autonomic_nervous0.69658066
140MP0000681_abnormal_thyroid_gland0.69583642
141MP0002128_abnormal_blood_circulation0.68576458
142MP0002697_abnormal_eye_size0.67850856
143MP0002086_abnormal_extraembryonic_tissu0.67087463
144MP0002925_abnormal_cardiovascular_devel0.67057846
145MP0004133_heterotaxia0.66306620
146MP0002111_abnormal_tail_morphology0.66130489
147MP0009780_abnormal_chondrocyte_physiolo0.65374854
148MP0009643_abnormal_urine_homeostasis0.64791402
149MP0000733_abnormal_muscle_development0.64462817
150MP0003283_abnormal_digestive_organ0.64175992
151MP0005623_abnormal_meninges_morphology0.63948292
152MP0000579_abnormal_nail_morphology0.63858578
153MP0005647_abnormal_sex_gland0.62782213

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.13378594
2Xanthomatosis (HP:0000991)4.17215782
3Hyperlipoproteinemia (HP:0010980)3.73848743
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67912617
5Intrahepatic cholestasis (HP:0001406)3.64965754
6Hypoalphalipoproteinemia (HP:0003233)3.62717796
7Esophageal varix (HP:0002040)3.37733672
8Hypolipoproteinemia (HP:0010981)3.30472441
9Complement deficiency (HP:0004431)3.29471376
10Hypobetalipoproteinemia (HP:0003563)3.29246748
11Polycythemia (HP:0001901)3.24960496
12Neurofibrillary tangles (HP:0002185)3.15241901
13Hyperglycinuria (HP:0003108)3.11382824
14Shallow orbits (HP:0000586)3.00458318
15Abnormality of aromatic amino acid family metabolism (HP:0004338)2.97652065
16Turricephaly (HP:0000262)2.94893048
17Hyperammonemia (HP:0001987)2.93905271
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90723086
19Abnormality of serine family amino acid metabolism (HP:0010894)2.85562409
20Abnormality of glycine metabolism (HP:0010895)2.85562409
21Spastic diplegia (HP:0001264)2.81763829
22Abnormality of complement system (HP:0005339)2.81274517
23Protrusio acetabuli (HP:0003179)2.79962353
24Obstructive sleep apnea (HP:0002870)2.79617605
25Hyperglycinemia (HP:0002154)2.79515723
26Coronal craniosynostosis (HP:0004440)2.79098636
27Broad metatarsal (HP:0001783)2.78901155
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75343113
29Short 4th metacarpal (HP:0010044)2.75343113
30Pseudobulbar signs (HP:0002200)2.72651246
31Split foot (HP:0001839)2.61669458
32Hypercholesterolemia (HP:0003124)2.60988426
33Abnormality of the 4th metacarpal (HP:0010012)2.58555336
34Prolonged partial thromboplastin time (HP:0003645)2.57296654
35Epidermoid cyst (HP:0200040)2.52611561
36Back pain (HP:0003418)2.51821186
37Aplasia involving bones of the upper limbs (HP:0009823)2.51519006
38Aplasia of the phalanges of the hand (HP:0009802)2.51519006
39Aplasia involving bones of the extremities (HP:0009825)2.51519006
40Cerebral inclusion bodies (HP:0100314)2.49091643
41Insomnia (HP:0100785)2.44422343
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41957960
43Distal upper limb amyotrophy (HP:0007149)2.41078486
44Upper limb amyotrophy (HP:0009129)2.41078486
45Ketosis (HP:0001946)2.35141484
46Lymphangioma (HP:0100764)2.32923694
47Action tremor (HP:0002345)2.30321895
48Cerebral aneurysm (HP:0004944)2.30257018
49Myokymia (HP:0002411)2.28587365
50Megalencephaly (HP:0001355)2.26861480
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.26366151
52Bronchomalacia (HP:0002780)2.24359398
53Myocardial infarction (HP:0001658)2.18123621
54Renovascular hypertension (HP:0100817)2.16678376
55Atrophic scars (HP:0001075)2.14742230
56Hypoglycemic coma (HP:0001325)2.14713738
57Renal duplication (HP:0000075)2.14452660
58Visceral angiomatosis (HP:0100761)2.14274028
59Neonatal short-limb short stature (HP:0008921)2.13999219
60Hepatocellular carcinoma (HP:0001402)2.12996666
61Hand muscle atrophy (HP:0009130)2.12421021
62Ulnar bowing (HP:0003031)2.11865693
63Abnormality of the common coagulation pathway (HP:0010990)2.10624736
64Mitral regurgitation (HP:0001653)2.10338457
65Hyperacusis (HP:0010780)2.10016018
66Growth hormone excess (HP:0000845)2.09653802
67Hemorrhage of the eye (HP:0011885)2.09293634
68Hyperparathyroidism (HP:0000843)2.08900540
69Vertebral compression fractures (HP:0002953)2.08677635
70Alopecia of scalp (HP:0002293)2.07982906
71Long toe (HP:0010511)2.07655229
72Premature rupture of membranes (HP:0001788)2.07428713
73Neonatal death (HP:0003811)2.05218443
74Right ventricular cardiomyopathy (HP:0011663)2.04601987
75Adactyly (HP:0009776)2.03057702
76Broad face (HP:0000283)2.02350590
77Selective tooth agenesis (HP:0001592)2.02258697
78Abnormality of the diencephalon (HP:0010662)2.02030027
79Cortical dysplasia (HP:0002539)2.01676755
80Spinal rigidity (HP:0003306)2.01544142
81Mildly elevated creatine phosphokinase (HP:0008180)2.01375214
82Alacrima (HP:0000522)2.00955542
83Vascular tortuosity (HP:0004948)2.00491042
84Mitral valve prolapse (HP:0001634)1.99261969
85Deviation of the hallux (HP:0010051)1.97597046
86Hemangiomatosis (HP:0007461)1.97184732
87Hammertoe (HP:0001765)1.96675934
88Peritonitis (HP:0002586)1.96499184
89Joint hemorrhage (HP:0005261)1.95902344
90Short nail (HP:0001799)1.93676696
91Aortic aneurysm (HP:0004942)1.92931721
92Overriding aorta (HP:0002623)1.92616466
93Delayed CNS myelination (HP:0002188)1.91913568
94Aneurysm (HP:0002617)1.91172849
95Systemic lupus erythematosus (HP:0002725)1.90894160
96Hallux valgus (HP:0001822)1.90187699
97Acanthosis nigricans (HP:0000956)1.88540980
98Reticulocytosis (HP:0001923)1.87599021
99Anomalous pulmonary venous return (HP:0010772)1.87440053
100Ankle clonus (HP:0011448)1.87312585
101Peripheral hypomyelination (HP:0007182)1.87251318
102Bladder diverticulum (HP:0000015)1.86905846
103Supranuclear gaze palsy (HP:0000605)1.86360003
104Distal lower limb muscle weakness (HP:0009053)1.85320144
105Down-sloping shoulders (HP:0200021)1.85314656
106Arterial tortuosity (HP:0005116)1.82495002
107Hydroureter (HP:0000072)1.82428272
108Abnormal eating behavior (HP:0100738)1.82388251
109Arnold-Chiari malformation (HP:0002308)1.82300965
110Advanced eruption of teeth (HP:0006288)1.80555438
111Ankle contracture (HP:0006466)1.80294370
112Abnormality of the intrinsic pathway (HP:0010989)1.80204445
113Amyloidosis (HP:0011034)1.79022864
114Humeroradial synostosis (HP:0003041)1.78745273
115Synostosis involving the elbow (HP:0003938)1.78745273
116Absent toe (HP:0010760)1.78015567
117Hypoplastic toenails (HP:0001800)1.77310913
118Bifid scrotum (HP:0000048)1.77256194
119Mesangial abnormality (HP:0001966)1.76933238
120Camptodactyly of toe (HP:0001836)1.76863186
121Abnormality of the lower motor neuron (HP:0002366)1.76338445
122Short hallux (HP:0010109)1.75449564
123Wormian bones (HP:0002645)1.75194227
124Abnormal cartilage morphology (HP:0002763)1.75003297
125Foot dorsiflexor weakness (HP:0009027)1.74898830
126Aortic dissection (HP:0002647)1.74659356
127Hypercortisolism (HP:0001578)1.73901246
128Fat malabsorption (HP:0002630)1.72089234
129Abnormality of pyrimidine metabolism (HP:0004353)1.71578767
130Skull defect (HP:0001362)1.70986627
131Ectopia lentis (HP:0001083)1.70521253
132Abnormality of the aortic arch (HP:0012303)1.70340782
133Hydroxyprolinuria (HP:0003080)1.70028249
134Abnormality of proline metabolism (HP:0010907)1.70028249
135Partial duplication of thumb phalanx (HP:0009944)1.69772870
136Abnormality of the pulmonary veins (HP:0011718)1.69534751
137Elfin facies (HP:0004428)1.69333660
138Tetraparesis (HP:0002273)1.69306991
139Pulmonary artery stenosis (HP:0004415)1.68801454
140Axonal loss (HP:0003447)1.68778592
141Ketoacidosis (HP:0001993)1.68503675
142Laryngomalacia (HP:0001601)1.67836340
143Skin nodule (HP:0200036)1.67269017
144Malnutrition (HP:0004395)1.66950604
145Precocious puberty (HP:0000826)1.63649131
146Natal tooth (HP:0000695)1.63592731
147Hypoventilation (HP:0002791)1.62277653
148Hypercalcemia (HP:0003072)1.62263487
149Heterochromia iridis (HP:0001100)1.61950018
150Atelectasis (HP:0100750)1.61022075
151Fragile skin (HP:0001030)1.60682504
152Cervical subluxation (HP:0003308)1.60632899
153Sleep apnea (HP:0010535)1.60614913
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.59998545
155Partial duplication of the phalanx of hand (HP:0009999)1.59975520
156Vertebral arch anomaly (HP:0008438)1.59285603
157Abnormality of the foot musculature (HP:0001436)1.56625431
158Wrist flexion contracture (HP:0001239)1.56437318
159Hyperextensible skin (HP:0000974)1.56207790
160Distal lower limb amyotrophy (HP:0008944)1.56198527
161Nuclear cataract (HP:0100018)1.55701007
162Wide anterior fontanel (HP:0000260)1.55495215
163Mitral stenosis (HP:0001718)1.54302593
164Increased connective tissue (HP:0009025)1.54138880
165Hypoplasia of the iris (HP:0007676)1.53793071
166Lower limb amyotrophy (HP:0007210)1.52905725
167Increased variability in muscle fiber diameter (HP:0003557)1.51524903
168Ulnar claw (HP:0001178)1.51394282
169Polyphagia (HP:0002591)1.49775540
170Biconcave vertebral bodies (HP:0004586)1.48997219
171Neoplasm of the heart (HP:0100544)1.48330598
172Abnormality of dentin (HP:0010299)1.47854065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.77937375
2ERN13.26182818
3RIPK13.22363690
4SIK13.21943762
5EPHB22.87140747
6TIE12.67744340
7BCKDK2.67180587
8EPHA22.58285073
9MARK12.57703037
10LATS12.36637903
11PKN22.35936683
12NTRK12.31749483
13PDGFRA2.26640239
14PTK62.22211410
15FGFR42.20961365
16KDR2.19974025
17EPHA42.11244531
18MAP3K101.98472361
19PAK61.92883633
20DDR21.85472575
21LATS21.79879239
22ICK1.65649850
23LMTK21.64555504
24PAK41.52874112
25TGFBR21.52543592
26CAMK1D1.44040829
27BMX1.43102981
28FGFR21.42663833
29EPHB11.40996497
30PRPF4B1.39040650
31MST1R1.36795774
32TGFBR11.36605289
33CASK1.35164455
34EPHA31.30797883
35ARAF1.23302594
36NEK21.23155897
37NTRK31.20111547
38UHMK11.19553839
39LRRK21.17439813
40PTK21.13800538
41FGFR11.13549111
42CAMK2G1.12805134
43MET1.10962418
44BUB11.10456111
45FER1.10426316
46DYRK1B1.08377244
47NEK11.07540363
48ERBB21.07144037
49MAPK151.07101883
50PRKD31.07049087
51CAMK2B1.05318977
52MTOR1.05123173
53MARK21.03760234
54PDK41.01835433
55PDK31.01835433
56CDK61.01306856
57TYRO31.00036554
58FGFR31.00019868
59PIM20.98038342
60DMPK0.93980309
61ROCK20.91979131
62MAP2K20.91399614
63TTN0.91280449
64LIMK10.90340870
65CAMK1G0.87491136
66MAP3K60.85543502
67TAOK20.84971248
68SMG10.82053978
69PKN10.81878786
70PDK20.80823927
71SGK2230.80442896
72SGK4940.80442896
73GSK3A0.78874406
74STK100.77541606
75NEK60.77407760
76NTRK20.76840290
77RPS6KA20.76213933
78PAK20.75029500
79STK30.71454673
80MAP2K70.69115683
81CDK150.68564316
82CDK50.68104119
83CDK120.67503606
84PDGFRB0.67147519
85CAMK2D0.67130435
86EEF2K0.66135030
87CDK11A0.65923870
88MAP3K30.65899822
89MINK10.65734729
90MAP3K80.65532856
91CDK180.65520931
92CDC42BPA0.62374666
93PRKD20.62208574
94TESK10.61830166
95CDK140.61450416
96MAPKAPK30.61368213
97DAPK20.60550330
98BCR0.59439045
99KSR20.58573995
100IRAK30.58537835
101AKT20.57904555
102DYRK30.57607393
103KSR10.56291416
104RPS6KA40.56151027
105ERBB40.54311009
106MAP2K10.53817302
107STK380.52410415
108SIK20.49738020
109CDK40.49625354
110RET0.49412797
111PRKCZ0.48414488
112MAPK110.48006440
113ABL20.47271381
114MAPK100.46305724
115PTK2B0.45537502
116JAK20.44771104
117ROCK10.41595627
118CAMKK10.41407232
119HIPK20.41365771
120CSNK1A1L0.40911135
121PHKG20.40762702
122PHKG10.40762702
123MOS0.40395740
124TAOK10.40113772
125MAPK120.39454506
126ILK0.38423604
127MYLK0.37981448
128EGFR0.37934671
129ERBB30.37715341
130TESK20.36458325
131DYRK20.36382949
132BRAF0.35608825
133RPS6KB20.35319906
134SRC0.33445663
135MAP3K110.32838777
136RPS6KA10.32050795
137PDPK10.31269895
138SGK30.31097860
139NEK90.30884444
140MAP3K90.30651492
141PRKAA10.29287024
142PRKD10.28978437
143PAK30.28096927
144PRKAA20.27975507
145CDK70.27403132
146MAP2K30.26884484
147TBK10.26864436

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.09201572
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.28099866
3Arginine biosynthesis_Homo sapiens_hsa002202.72669108
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65287325
5Fatty acid degradation_Homo sapiens_hsa000712.59165362
6Complement and coagulation cascades_Homo sapiens_hsa046102.36486121
7PPAR signaling pathway_Homo sapiens_hsa033202.30050219
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24898006
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16384922
10Fatty acid metabolism_Homo sapiens_hsa012122.13636771
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.05605391
12Tryptophan metabolism_Homo sapiens_hsa003802.03509205
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02142881
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01906238
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96767339
16Fatty acid biosynthesis_Homo sapiens_hsa000611.90149957
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81144707
18Caffeine metabolism_Homo sapiens_hsa002321.78192357
19Bile secretion_Homo sapiens_hsa049761.72189555
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66748174
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62462774
22Chemical carcinogenesis_Homo sapiens_hsa052041.60023577
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59681756
24Propanoate metabolism_Homo sapiens_hsa006401.58399164
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58071553
26Butanoate metabolism_Homo sapiens_hsa006501.53042427
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48489727
28Fat digestion and absorption_Homo sapiens_hsa049751.42745099
29Staphylococcus aureus infection_Homo sapiens_hsa051501.42521009
30Peroxisome_Homo sapiens_hsa041461.41815094
31Axon guidance_Homo sapiens_hsa043601.39349652
32beta-Alanine metabolism_Homo sapiens_hsa004101.38658522
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38627129
34Selenocompound metabolism_Homo sapiens_hsa004501.36047024
35Synaptic vesicle cycle_Homo sapiens_hsa047211.34381991
36Basal cell carcinoma_Homo sapiens_hsa052171.32394657
37Biosynthesis of amino acids_Homo sapiens_hsa012301.30271610
38Histidine metabolism_Homo sapiens_hsa003401.28585412
39Cocaine addiction_Homo sapiens_hsa050301.26107548
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.24729628
41Retinol metabolism_Homo sapiens_hsa008301.24184201
42Vibrio cholerae infection_Homo sapiens_hsa051101.16690503
43Gap junction_Homo sapiens_hsa045401.16672723
44Lysine degradation_Homo sapiens_hsa003101.16380497
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13955676
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09920574
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.09713333
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09454129
49Carbon metabolism_Homo sapiens_hsa012001.07454481
50Melanogenesis_Homo sapiens_hsa049161.05745069
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04923625
52Vitamin B6 metabolism_Homo sapiens_hsa007501.02466673
53Phenylalanine metabolism_Homo sapiens_hsa003601.02313239
54Pentose phosphate pathway_Homo sapiens_hsa000301.02281859
55Gastric acid secretion_Homo sapiens_hsa049711.01988396
56Insulin secretion_Homo sapiens_hsa049111.00104358
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99524889
58GABAergic synapse_Homo sapiens_hsa047270.99452216
59Glutamatergic synapse_Homo sapiens_hsa047240.99190560
60Estrogen signaling pathway_Homo sapiens_hsa049150.97545196
61Circadian entrainment_Homo sapiens_hsa047130.95962837
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95120827
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95120010
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93936832
65Pyruvate metabolism_Homo sapiens_hsa006200.93746574
66Notch signaling pathway_Homo sapiens_hsa043300.93575490
67Sulfur relay system_Homo sapiens_hsa041220.93460612
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91865784
69Vitamin digestion and absorption_Homo sapiens_hsa049770.90308012
70Nicotine addiction_Homo sapiens_hsa050330.88107116
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87728372
72Tyrosine metabolism_Homo sapiens_hsa003500.87345836
73ABC transporters_Homo sapiens_hsa020100.87164784
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86850404
75Amphetamine addiction_Homo sapiens_hsa050310.86823186
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86745732
77Thyroid hormone synthesis_Homo sapiens_hsa049180.85988867
78Hippo signaling pathway_Homo sapiens_hsa043900.85816349
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85681923
80Arginine and proline metabolism_Homo sapiens_hsa003300.84715372
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.83736581
82Dopaminergic synapse_Homo sapiens_hsa047280.83640651
83Dilated cardiomyopathy_Homo sapiens_hsa054140.83581107
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.82728527
85Long-term potentiation_Homo sapiens_hsa047200.81482627
86Endometrial cancer_Homo sapiens_hsa052130.81397795
87GnRH signaling pathway_Homo sapiens_hsa049120.80394293
88ErbB signaling pathway_Homo sapiens_hsa040120.79857006
89Glycerolipid metabolism_Homo sapiens_hsa005610.78851125
90Glioma_Homo sapiens_hsa052140.78364280
91Prion diseases_Homo sapiens_hsa050200.74082733
92Steroid biosynthesis_Homo sapiens_hsa001000.74060919
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.73253122
94Starch and sucrose metabolism_Homo sapiens_hsa005000.72413387
95Hedgehog signaling pathway_Homo sapiens_hsa043400.72285937
96Insulin resistance_Homo sapiens_hsa049310.72091490
97Folate biosynthesis_Homo sapiens_hsa007900.71660343
98Bladder cancer_Homo sapiens_hsa052190.71055959
99cAMP signaling pathway_Homo sapiens_hsa040240.69639291
100Salivary secretion_Homo sapiens_hsa049700.67563542
101Proteoglycans in cancer_Homo sapiens_hsa052050.66568105
102Cholinergic synapse_Homo sapiens_hsa047250.66474366
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.66153203
104Rap1 signaling pathway_Homo sapiens_hsa040150.66084228
105Glutathione metabolism_Homo sapiens_hsa004800.64762920
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.64761200
107Choline metabolism in cancer_Homo sapiens_hsa052310.61735104
108Renin secretion_Homo sapiens_hsa049240.60471808
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.60327411
110Adherens junction_Homo sapiens_hsa045200.59870984
111Pancreatic secretion_Homo sapiens_hsa049720.59361611
112Dorso-ventral axis formation_Homo sapiens_hsa043200.58839186
113ECM-receptor interaction_Homo sapiens_hsa045120.58706688
114VEGF signaling pathway_Homo sapiens_hsa043700.58694702
115Morphine addiction_Homo sapiens_hsa050320.57912526
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55736955
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51111117
118Sulfur metabolism_Homo sapiens_hsa009200.50595937
119Wnt signaling pathway_Homo sapiens_hsa043100.50142272
120TGF-beta signaling pathway_Homo sapiens_hsa043500.49817763
121Fructose and mannose metabolism_Homo sapiens_hsa000510.48234830
122AMPK signaling pathway_Homo sapiens_hsa041520.46660900
123Fatty acid elongation_Homo sapiens_hsa000620.46588115
124Small cell lung cancer_Homo sapiens_hsa052220.43858778
125Focal adhesion_Homo sapiens_hsa045100.40606351
126One carbon pool by folate_Homo sapiens_hsa006700.38331573
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36259895
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35598890
129Malaria_Homo sapiens_hsa051440.35310903
130Amoebiasis_Homo sapiens_hsa051460.35034173
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.34045744
132MicroRNAs in cancer_Homo sapiens_hsa052060.32590219
133Tight junction_Homo sapiens_hsa045300.32474472
134Protein digestion and absorption_Homo sapiens_hsa049740.30533960
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28395981
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28288601
137Insulin signaling pathway_Homo sapiens_hsa049100.27994999
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27638365
139Galactose metabolism_Homo sapiens_hsa000520.26657730
140Mineral absorption_Homo sapiens_hsa049780.25466434
141Glucagon signaling pathway_Homo sapiens_hsa049220.24729819
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24571051
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23821684
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.23113874
145Systemic lupus erythematosus_Homo sapiens_hsa053220.22338587
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20588726
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20398614

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