CDC42EP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)6.25643225
2regulation of guanylate cyclase activity (GO:0031282)5.59577219
3positive regulation of respiratory burst (GO:0060267)5.45336280
4glomerular filtration (GO:0003094)5.39243637
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.30348229
6renal filtration (GO:0097205)5.08361217
7intestinal epithelial cell development (GO:0060576)5.02288027
8antibacterial humoral response (GO:0019731)4.69028358
9antimicrobial humoral response (GO:0019730)4.60537793
10virion attachment to host cell (GO:0019062)4.57756179
11adhesion of symbiont to host cell (GO:0044650)4.57756179
12regulation of cellular extravasation (GO:0002691)4.50241980
13NADH metabolic process (GO:0006734)4.46511008
14positive regulation of guanylate cyclase activity (GO:0031284)4.19803193
15formation of translation preinitiation complex (GO:0001731)4.18043263
16viral transcription (GO:0019083)4.14636650
17maturation of SSU-rRNA (GO:0030490)4.12306855
18translational termination (GO:0006415)4.06141559
19regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.01993684
20endocrine process (GO:0050886)4.01993684
21regulation of systemic arterial blood pressure by hormone (GO:0001990)4.01993684
22ribosomal small subunit biogenesis (GO:0042274)3.98596227
23adhesion of symbiont to host (GO:0044406)3.90538582
24renal system process involved in regulation of blood volume (GO:0001977)3.88653940
25DNA deamination (GO:0045006)3.86756608
26ribosomal large subunit biogenesis (GO:0042273)3.85960216
27regulation of respiratory burst (GO:0060263)3.83784561
28ribosomal small subunit assembly (GO:0000028)3.80523220
29interferon-gamma secretion (GO:0072643)3.78890795
30complement activation, classical pathway (GO:0006958)3.73088453
31positive regulation of Cdc42 GTPase activity (GO:0043089)3.70775165
32translational elongation (GO:0006414)3.68521115
33regulation of systemic arterial blood pressure (GO:0003073)3.66105777
34oligosaccharide biosynthetic process (GO:0009312)3.63412289
35purine nucleobase biosynthetic process (GO:0009113)3.62055274
36translational initiation (GO:0006413)3.58512226
37regulation of vitamin metabolic process (GO:0030656)3.56637813
38ribosome assembly (GO:0042255)3.40260725
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39408732
40eosinophil chemotaxis (GO:0048245)3.37086399
41fat-soluble vitamin biosynthetic process (GO:0042362)3.36370088
42regulation of cGMP biosynthetic process (GO:0030826)3.35107858
43ethanol oxidation (GO:0006069)3.31080115
44protein targeting to ER (GO:0045047)3.29183237
45epoxygenase P450 pathway (GO:0019373)3.28854019
46peptide catabolic process (GO:0043171)3.28596739
47nucleobase biosynthetic process (GO:0046112)3.27743327
48viral life cycle (GO:0019058)3.27276475
49cotranslational protein targeting to membrane (GO:0006613)3.26335566
50lipoprotein transport (GO:0042953)3.23755259
51receptor guanylyl cyclase signaling pathway (GO:0007168)3.23573537
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22195781
53sequestering of extracellular ligand from receptor (GO:0035581)3.21562966
54folic acid metabolic process (GO:0046655)3.21372779
55cellular protein complex disassembly (GO:0043624)3.21052321
56trophectodermal cell differentiation (GO:0001829)3.17348776
57fructose metabolic process (GO:0006000)3.15540979
58urea cycle (GO:0000050)3.14988269
59hormone catabolic process (GO:0042447)3.13575352
60paraxial mesoderm development (GO:0048339)3.12017350
61protein localization to endoplasmic reticulum (GO:0070972)3.09073242
62nucleoside diphosphate biosynthetic process (GO:0009133)3.08943054
63maintenance of gastrointestinal epithelium (GO:0030277)3.08782193
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08064785
65lung morphogenesis (GO:0060425)3.07991125
66ribonucleoprotein complex biogenesis (GO:0022613)3.07855924
67regulation of posttranscriptional gene silencing (GO:0060147)3.07588251
68regulation of gene silencing by miRNA (GO:0060964)3.07588251
69regulation of gene silencing by RNA (GO:0060966)3.07588251
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06784989
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05550097
72protein retention in ER lumen (GO:0006621)3.05486519
73anterior/posterior axis specification, embryo (GO:0008595)3.04903656
74positive regulation of SMAD protein import into nucleus (GO:0060391)3.04871736
75phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.03819307
76regulation of cGMP metabolic process (GO:0030823)3.02566952
77galactose catabolic process (GO:0019388)3.01705958
78proteasome assembly (GO:0043248)3.01543868
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.01344399
80regulation of cardioblast differentiation (GO:0051890)2.98958223
81translation (GO:0006412)2.97692019
82regulation of extracellular matrix disassembly (GO:0010715)2.97096085
83eosinophil migration (GO:0072677)2.96629147
84regulation of SMAD protein import into nucleus (GO:0060390)2.96256391
85actin filament depolymerization (GO:0030042)2.95608940
86nucleotide-sugar biosynthetic process (GO:0009226)2.95371659
87barbed-end actin filament capping (GO:0051016)2.95185816
88folic acid transport (GO:0015884)2.94467736
89diacylglycerol metabolic process (GO:0046339)2.94143668
90complement activation (GO:0006956)2.93842082
91proline biosynthetic process (GO:0006561)2.93572871
92negative regulation of leukocyte chemotaxis (GO:0002689)2.93497555
93cyclooxygenase pathway (GO:0019371)2.92621716
94mitotic metaphase plate congression (GO:0007080)2.90964567
95urea metabolic process (GO:0019627)2.90746053
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90684508
97fibril organization (GO:0097435)2.88537382
98cell differentiation involved in embryonic placenta development (GO:0060706)2.88455205
99GDP-mannose metabolic process (GO:0019673)2.88252672
100arginine metabolic process (GO:0006525)2.86818899
101nodal signaling pathway (GO:0038092)2.85809305
102ethanol metabolic process (GO:0006067)2.85210414
103respiratory tube development (GO:0030323)2.84483679
104protein complex disassembly (GO:0043241)2.82111274
105positive regulation of glycoprotein metabolic process (GO:1903020)2.80863065
106regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80453151
107positive regulation of fatty acid beta-oxidation (GO:0032000)2.79439041
108peptide hormone processing (GO:0016486)2.79412554
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79412272
110midgut development (GO:0007494)2.79256444
111transcytosis (GO:0045056)2.78792373
112* positive regulation of pseudopodium assembly (GO:0031274)2.78753038
113cGMP-mediated signaling (GO:0019934)2.78739183
114intestinal absorption (GO:0050892)2.78717072
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.78287166
116O-glycan processing (GO:0016266)2.77946046
117regulation of cholesterol homeostasis (GO:2000188)2.76114576
118epithelial cell-cell adhesion (GO:0090136)2.75016447
119positive regulation of glycoprotein biosynthetic process (GO:0010560)2.73821554
120labyrinthine layer development (GO:0060711)2.73558898
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73425255
122nitrogen cycle metabolic process (GO:0071941)2.72353180
123regulation of bile acid biosynthetic process (GO:0070857)2.72292972
124extracellular fibril organization (GO:0043206)2.71356984
125bile acid and bile salt transport (GO:0015721)2.71203989
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68416044
127macromolecular complex disassembly (GO:0032984)2.68207245
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68206496
129antigen processing and presentation of endogenous antigen (GO:0019883)2.67978271
130glycosphingolipid catabolic process (GO:0046479)2.67866520
131COPI coating of Golgi vesicle (GO:0048205)2.66317550
132Golgi transport vesicle coating (GO:0048200)2.66317550
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66192841
134negative regulation of androgen receptor signaling pathway (GO:0060766)2.65788774
135hemidesmosome assembly (GO:0031581)2.65292385
136glycolipid catabolic process (GO:0019377)2.65037988
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63852471
138positive regulation of receptor recycling (GO:0001921)2.62696332
139modified amino acid transport (GO:0072337)2.62425016
140vitamin transmembrane transport (GO:0035461)2.62417545
141regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62360425
142uronic acid metabolic process (GO:0006063)2.62342466
143glucuronate metabolic process (GO:0019585)2.62342466
144tight junction assembly (GO:0070830)2.60292208
145chronic inflammatory response (GO:0002544)2.59863866
146blastocyst development (GO:0001824)2.59386664
147cellular response to nutrient (GO:0031670)2.59181057
148receptor recycling (GO:0001881)2.58556826
149lung-associated mesenchyme development (GO:0060484)2.58109769
150ribosome biogenesis (GO:0042254)2.58016562
151branching involved in mammary gland duct morphogenesis (GO:0060444)2.57987338
152multicellular organismal catabolic process (GO:0044243)2.57963441
153keratan sulfate catabolic process (GO:0042340)2.57618293
154desmosome organization (GO:0002934)2.57304191
155notochord development (GO:0030903)2.55120449
156nucleobase-containing small molecule interconversion (GO:0015949)2.54623408
157cellular glucuronidation (GO:0052695)2.54563369
158cellular response to pH (GO:0071467)2.54277760
159arginine catabolic process (GO:0006527)2.54016949
160negative regulation of ligase activity (GO:0051352)2.53115974
161negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53115974
162regulation of hippo signaling (GO:0035330)2.51455613
163UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50142205
164negative regulation of keratinocyte proliferation (GO:0010839)2.49950331
165multicellular organismal macromolecule metabolic process (GO:0044259)2.49441614
166vitamin A metabolic process (GO:0006776)2.48788707
167chondrocyte proliferation (GO:0035988)2.48314656
168multicellular organismal metabolic process (GO:0044236)2.46132431
169oxidative phosphorylation (GO:0006119)2.45703773
170drug metabolic process (GO:0017144)2.45537282
171regulation of mitotic spindle organization (GO:0060236)2.44800542
172kinetochore assembly (GO:0051382)2.44722816
173regulation of spindle organization (GO:0090224)2.44438382
174negative regulation of translational initiation (GO:0045947)2.44340326
175positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43636676
176rRNA modification (GO:0000154)2.43633519
177regulation of gastrulation (GO:0010470)2.41259494
178heterochromatin organization (GO:0070828)2.39607099
179regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.39553100
180calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37864316
181transcription from mitochondrial promoter (GO:0006390)2.37608501
182DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37038530
183DNA damage response, detection of DNA damage (GO:0042769)2.36433867
184spliceosomal snRNP assembly (GO:0000387)2.35831605
185signal transduction involved in DNA integrity checkpoint (GO:0072401)2.35582546
186signal transduction involved in DNA damage checkpoint (GO:0072422)2.35582546
187negative regulation of cell fate specification (GO:0009996)2.34729618
188signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.33284932
189signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.33284932
190signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.33284932
191establishment of protein localization to mitochondrial membrane (GO:0090151)2.33125758
192establishment of apical/basal cell polarity (GO:0035089)2.32820607
193rRNA processing (GO:0006364)2.32614087
194regulation of cellular amino acid metabolic process (GO:0006521)2.32341066
195rRNA metabolic process (GO:0016072)2.32048980
196hepatocyte apoptotic process (GO:0097284)2.30978486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.96166127
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.62985159
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.60123567
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95736964
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90063660
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81898762
7E2F7_22180533_ChIP-Seq_HELA_Human2.79570370
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.58992197
9LXR_22292898_ChIP-Seq_THP-1_Human2.51541394
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47881186
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47495040
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42862168
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38048463
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35466802
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33894919
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21410939
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19539810
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.17584979
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17410108
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17410108
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17410108
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.16574702
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14729168
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.12056844
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10612963
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10312705
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05397259
28AR_21909140_ChIP-Seq_LNCAP_Human2.04969570
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04336493
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.04090873
31ESR2_21235772_ChIP-Seq_MCF-7_Human2.00295331
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99130375
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.97753363
34* SOX2_20726797_ChIP-Seq_SW620_Human1.97235809
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.95593214
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94566768
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91258585
38XRN2_22483619_ChIP-Seq_HELA_Human1.89333004
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89104654
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.84645991
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82832984
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81926151
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75896752
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74540202
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.73229716
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71599854
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70763635
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.66978943
49ZNF263_19887448_ChIP-Seq_K562_Human1.66637579
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65638665
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65066962
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59524458
53OCT4_18692474_ChIP-Seq_MEFs_Mouse1.56373339
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.55610206
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.54147396
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53394108
57ATF3_27146783_Chip-Seq_COLON_Human1.51683763
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51553129
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50337233
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49328823
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49287758
62SOX2_18692474_ChIP-Seq_MEFs_Mouse1.49132974
63* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48786084
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46328038
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44008956
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43766656
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43502237
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42479166
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42459352
70DCP1A_22483619_ChIP-Seq_HELA_Human1.41181067
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39488647
72* TET1_21451524_ChIP-Seq_MESCs_Mouse1.39345159
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38800967
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.38238204
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37748256
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37415074
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36706358
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36622700
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.34669803
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.34650674
81* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34352990
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.34198490
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.33993074
84CTCF_27219007_Chip-Seq_Bcells_Human1.33462663
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33248201
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33097340
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32715684
88TTF2_22483619_ChIP-Seq_HELA_Human1.32186522
89NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31668124
90* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31135485
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31108445
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30609211
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30032534
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29902408
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29716066
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29239674
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28810060
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28636911
99GABP_19822575_ChIP-Seq_HepG2_Human1.28113820
100GATA6_25053715_ChIP-Seq_YYC3_Human1.26578473
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24451070
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23489666
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22171136
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20504148
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.20481671
106SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19803464
107* RACK7_27058665_Chip-Seq_MCF-7_Human1.19134000
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.19103453
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19015308
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18948730
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.18214437
112KLF5_25053715_ChIP-Seq_YYC3_Human1.17938152
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17569562
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17339191
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17101388
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16896464
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16226265
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15865303
119SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15859583
120* GATA4_25053715_ChIP-Seq_YYC3_Human1.15543314
121* SA1_27219007_Chip-Seq_Bcells_Human1.14535149
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13786987
123VDR_21846776_ChIP-Seq_THP-1_Human1.10431736
124* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09713057
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09197386
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07809559
127VDR_23849224_ChIP-Seq_CD4+_Human1.07545048
128TP63_22573176_ChIP-Seq_HFKS_Human1.06969088
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06830951
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05097098
131BCL6_27268052_Chip-Seq_Bcells_Human1.04973493
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.04930356
133CLOCK_20551151_ChIP-Seq_293T_Human1.04555201
134DROSHA_22980978_ChIP-Seq_HELA_Human1.03754602
135JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03735432
136CREB1_26743006_Chip-Seq_LNCaP_Human1.02589378
137* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02311211
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02134554
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02062683
140POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00599895
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99513896
142BCOR_27268052_Chip-Seq_Bcells_Human0.98202438
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97690077
144VDR_24763502_ChIP-Seq_THP-1_Human0.97576627
145SMC4_20622854_ChIP-Seq_HELA_Human0.97149511
146KDM5A_27292631_Chip-Seq_BREAST_Human0.96670462
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96072441
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95527842
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.95418177
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.94500757
151TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94412562
152POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94345580
153SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93452693
154KDM2B_26808549_Chip-Seq_K562_Human0.93400790
155WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93297230
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93261345
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93155946
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93126539
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92553779
160STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92116615
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91991504
162HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91818081
163ELK3_25401928_ChIP-Seq_HUVEC_Human0.91370247
164* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91243795
165STAT1_20625510_ChIP-Seq_HELA_Human0.90446898
166TP53_22127205_ChIP-Seq_IMR90_Human0.90200009
167ESR1_21235772_ChIP-Seq_MCF-7_Human0.90123709
168TBX20_22080862_ChIP-Seq_HEART_Mouse0.88825576
169TBX20_22328084_ChIP-Seq_HEART_Mouse0.88825576
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88467151
171P68_20966046_ChIP-Seq_HELA_Human0.86738276
172* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86441517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.47253268
2MP0002139_abnormal_hepatobiliary_system3.27171438
3MP0003705_abnormal_hypodermis_morpholog3.10405581
4MP0010352_gastrointestinal_tract_polyps3.07586176
5MP0000537_abnormal_urethra_morphology2.97001322
6MP0004957_abnormal_blastocyst_morpholog2.94857542
7MP0010030_abnormal_orbit_morphology2.90281716
8MP0008438_abnormal_cutaneous_collagen2.76128041
9MP0010155_abnormal_intestine_physiology2.67626399
10MP0003941_abnormal_skin_development2.59773414
11MP0004858_abnormal_nervous_system2.54828711
12MP0005275_abnormal_skin_tensile2.40673331
13MP0005085_abnormal_gallbladder_physiolo2.31465645
14MP0003111_abnormal_nucleus_morphology2.24826367
15MP0010234_abnormal_vibrissa_follicle2.18608314
16MP0003878_abnormal_ear_physiology2.16188948
17MP0005377_hearing/vestibular/ear_phenot2.16188948
18MP0003183_abnormal_peptide_metabolism2.12313858
19MP0003283_abnormal_digestive_organ2.11300861
20MP0004264_abnormal_extraembryonic_tissu2.06752731
21MP0005409_darkened_coat_color2.04801496
22MP0000462_abnormal_digestive_system2.03199290
23MP0009053_abnormal_anal_canal2.00388939
24MP0009379_abnormal_foot_pigmentation2.00225566
25MP0001664_abnormal_digestion1.95526381
26MP0003315_abnormal_perineum_morphology1.88739679
27MP0005503_abnormal_tendon_morphology1.84945696
28MP0005365_abnormal_bile_salt1.83730680
29MP0003119_abnormal_digestive_system1.68931405
30MP0003077_abnormal_cell_cycle1.65066731
31MP0005367_renal/urinary_system_phenotyp1.61414295
32MP0000516_abnormal_urinary_system1.61414295
33MP0009840_abnormal_foam_cell1.59372659
34MP0003123_paternal_imprinting1.56889353
35MP0005023_abnormal_wound_healing1.56595564
36MP0000490_abnormal_crypts_of1.54560443
37MP0003718_maternal_effect1.53946345
38MP0005166_decreased_susceptibility_to1.53498064
39MP0001663_abnormal_digestive_system1.51447504
40MP0008932_abnormal_embryonic_tissue1.51182674
41MP0002796_impaired_skin_barrier1.48514384
42MP0002060_abnormal_skin_morphology1.47798924
43MP0003566_abnormal_cell_adhesion1.45007453
44MP0003806_abnormal_nucleotide_metabolis1.43719871
45MP0001730_embryonic_growth_arrest1.43165553
46MP0004272_abnormal_basement_membrane1.39688204
47MP0005381_digestive/alimentary_phenotyp1.39420697
48MP0001666_abnormal_nutrient_absorption1.39239041
49MP0002896_abnormal_bone_mineralization1.38811145
50MP0001873_stomach_inflammation1.37726067
51MP0000762_abnormal_tongue_morphology1.37641515
52MP0003115_abnormal_respiratory_system1.35477319
53MP0003724_increased_susceptibility_to1.33701339
54MP0004782_abnormal_surfactant_physiolog1.33151692
55MP0004133_heterotaxia1.31498696
56MP0000477_abnormal_intestine_morphology1.29499764
57MP0006054_spinal_hemorrhage1.26948670
58MP0000013_abnormal_adipose_tissue1.26903756
59MP0009384_cardiac_valve_regurgitation1.26450600
60MP0009643_abnormal_urine_homeostasis1.24260167
61MP0003329_amyloid_beta_deposits1.23966139
62MP0002111_abnormal_tail_morphology1.22498726
63MP0001672_abnormal_embryogenesis/_devel1.22229099
64MP0005380_embryogenesis_phenotype1.22229099
65MP0005058_abnormal_lysosome_morphology1.22111031
66MP0005501_abnormal_skin_physiology1.19811786
67MP0002086_abnormal_extraembryonic_tissu1.19618133
68MP0001697_abnormal_embryo_size1.18861848
69MP0000350_abnormal_cell_proliferation1.18769855
70MP0002085_abnormal_embryonic_tissue1.16800957
71MP0004147_increased_porphyrin_level1.16717884
72MP0001849_ear_inflammation1.15613194
73MP0003191_abnormal_cellular_cholesterol1.14517367
74MP0001765_abnormal_ion_homeostasis1.11508551
75MP0001533_abnormal_skeleton_physiology1.10440573
76MP0003786_premature_aging1.09171284
77MP0005508_abnormal_skeleton_morphology1.08731863
78MP0004197_abnormal_fetal_growth/weight/1.07269773
79MP0002138_abnormal_hepatobiliary_system1.06907527
80MP0003984_embryonic_growth_retardation1.06813698
81MP0003937_abnormal_limbs/digits/tail_de1.06646675
82MP0010368_abnormal_lymphatic_system1.06004814
83MP0004019_abnormal_vitamin_homeostasis1.05453377
84MP0003567_abnormal_fetal_cardiomyocyte1.05262678
85MP0005165_increased_susceptibility_to1.04977228
86MP0004043_abnormal_pH_regulation1.04321872
87MP0002088_abnormal_embryonic_growth/wei1.04154982
88MP0005451_abnormal_body_composition1.04073557
89MP0003300_gastrointestinal_ulcer1.03609023
90MP0008007_abnormal_cellular_replicative1.02457677
91MP0003303_peritoneal_inflammation1.02375744
92MP0000465_gastrointestinal_hemorrhage1.02268876
93MP0002136_abnormal_kidney_physiology1.01890485
94MP0002933_joint_inflammation1.00484533
95MP0002084_abnormal_developmental_patter1.00250001
96MP0002098_abnormal_vibrissa_morphology0.97780802
97MP0003385_abnormal_body_wall0.97134053
98MP0003868_abnormal_feces_composition0.97091016
99MP0005390_skeleton_phenotype0.97001655
100MP0002876_abnormal_thyroid_physiology0.96444473
101MP0002080_prenatal_lethality0.95721790
102MP0001542_abnormal_bone_strength0.94838914
103MP0005360_urolithiasis0.94209669
104MP0003942_abnormal_urinary_system0.93829100
105MP0000467_abnormal_esophagus_morphology0.92622288
106MP0000566_synostosis0.92185044
107MP0003453_abnormal_keratinocyte_physiol0.90417216
108MP0000049_abnormal_middle_ear0.90283144
109MP0000249_abnormal_blood_vessel0.89868206
110MP0000604_amyloidosis0.89635593
111MP0003091_abnormal_cell_migration0.88961353
112MP0002998_abnormal_bone_remodeling0.88843351
113MP0010094_abnormal_chromosome_stability0.87965746
114MP0000534_abnormal_ureter_morphology0.87932974
115MP0003186_abnormal_redox_activity0.86955671
116MP0005670_abnormal_white_adipose0.86610262
117MP0002653_abnormal_ependyma_morphology0.84874471
118MP0002932_abnormal_joint_morphology0.84610514
119MP0002249_abnormal_larynx_morphology0.84516923
120MP0000733_abnormal_muscle_development0.84456988
121MP0003436_decreased_susceptibility_to0.84391219
122MP0000678_abnormal_parathyroid_gland0.84192811
123MP0000432_abnormal_head_morphology0.83467598
124MP0000613_abnormal_salivary_gland0.83166418
125MP0008004_abnormal_stomach_pH0.82730769
126MP0002132_abnormal_respiratory_system0.82462985
127MP0010329_abnormal_lipoprotein_level0.82305830
128MP0000470_abnormal_stomach_morphology0.81789457
129MP0000428_abnormal_craniofacial_morphol0.81384026
130MP0003755_abnormal_palate_morphology0.80761983
131MP0005395_other_phenotype0.80056617
132MP0009250_abnormal_appendicular_skeleto0.78661201
133MP0005076_abnormal_cell_differentiation0.78302793
134MP0003866_abnormal_defecation0.77571089
135MP0003936_abnormal_reproductive_system0.77055296
136MP0001958_emphysema0.76951256
137MP0001216_abnormal_epidermal_layer0.76467309
138MP0002089_abnormal_postnatal_growth/wei0.76387413
139MP0004947_skin_inflammation0.75910775
140MP0000230_abnormal_systemic_arterial0.75703467
141MP0000681_abnormal_thyroid_gland0.75573299
142MP0005332_abnormal_amino_acid0.74201193
143MP0000767_abnormal_smooth_muscle0.73703848
144MP0001756_abnormal_urination0.73485682
145MP0005595_abnormal_vascular_smooth0.73474864
146MP0001845_abnormal_inflammatory_respons0.72876361
147MP0002233_abnormal_nose_morphology0.72708452
148MP0006082_CNS_inflammation0.72614631
149MP0005636_abnormal_mineral_homeostasis0.72583489
150MP0000538_abnormal_urinary_bladder0.72165272
151MP0002295_abnormal_pulmonary_circulatio0.71872534
152MP0003448_altered_tumor_morphology0.71564638
153MP0000858_altered_metastatic_potential0.70404594
154MP0003279_aneurysm0.69712473
155MP0001243_abnormal_dermal_layer0.69585152
156MP0005257_abnormal_intraocular_pressure0.69380341
157MP0001790_abnormal_immune_system0.68948447
158MP0005387_immune_system_phenotype0.68948447
159MP0002166_altered_tumor_susceptibility0.68498186
160MP0001293_anophthalmia0.68384606
161MP0003879_abnormal_hair_cell0.66507729

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)5.82231112
2Ileus (HP:0002595)5.49442095
3Systemic lupus erythematosus (HP:0002725)4.75636899
4Hyperactive renin-angiotensin system (HP:0000841)4.16565778
5Protrusio acetabuli (HP:0003179)4.07647702
6Abnormality of proline metabolism (HP:0010907)3.77719631
7Hydroxyprolinuria (HP:0003080)3.77719631
8Trismus (HP:0000211)3.62895885
9Breast hypoplasia (HP:0003187)3.61347245
10Right ventricular cardiomyopathy (HP:0011663)3.58354709
11Decreased circulating renin level (HP:0003351)3.55710129
12Premature rupture of membranes (HP:0001788)3.40251285
13Aortic dissection (HP:0002647)3.16013695
14Abnormality of complement system (HP:0005339)3.12953848
15Abnormality of the nasal mucosa (HP:0000433)3.05846349
16Atrophic scars (HP:0001075)3.04765736
17Aortic aneurysm (HP:0004942)2.97541844
18Abnormality of the 1st metacarpal (HP:0010009)2.93741936
19Metabolic alkalosis (HP:0200114)2.91972115
20Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91623415
21Alopecia of scalp (HP:0002293)2.90499629
22Abnormality of renin-angiotensin system (HP:0000847)2.87273781
23Reticulocytopenia (HP:0001896)2.80549132
24Vascular tortuosity (HP:0004948)2.79517892
25Complement deficiency (HP:0004431)2.78158803
26Abnormal hemoglobin (HP:0011902)2.76370770
27Alkalosis (HP:0001948)2.75292239
28Glomerulonephritis (HP:0000099)2.74082926
29Fragile skin (HP:0001030)2.73824123
30Chronic diarrhea (HP:0002028)2.73643092
31Nephritis (HP:0000123)2.72308086
32Hemorrhage of the eye (HP:0011885)2.71553402
33Ankle contracture (HP:0006466)2.70827744
34Vertebral compression fractures (HP:0002953)2.62213389
35Bladder diverticulum (HP:0000015)2.58101301
36Rectal prolapse (HP:0002035)2.51956243
37Macrocytic anemia (HP:0001972)2.51542649
38Hyperparathyroidism (HP:0000843)2.48925711
39Micronodular cirrhosis (HP:0001413)2.47284595
40Malnutrition (HP:0004395)2.44697480
41Abnormality of cells of the erythroid lineage (HP:0012130)2.42520971
42Fat malabsorption (HP:0002630)2.42326941
43Peritonitis (HP:0002586)2.42051292
44Abnormality of the fetal cardiovascular system (HP:0010948)2.41202315
45Abnormal umbilical cord blood vessels (HP:0011403)2.41202315
46Single umbilical artery (HP:0001195)2.41202315
47Abnormality of the distal phalanges of the toes (HP:0010182)2.40622329
48Emphysema (HP:0002097)2.39157778
49Selective tooth agenesis (HP:0001592)2.38758297
50Aplasia/hypoplasia of the humerus (HP:0006507)2.37419345
51Arterial tortuosity (HP:0005116)2.35536639
52Colon cancer (HP:0003003)2.31932834
53Fragile nails (HP:0001808)2.30907403
54Gastrointestinal dysmotility (HP:0002579)2.29972424
55Genu recurvatum (HP:0002816)2.29875916
56Short phalanx of the thumb (HP:0009660)2.29571136
57Abnormality of abdominal situs (HP:0011620)2.28610482
58Abdominal situs inversus (HP:0003363)2.28610482
59Blue sclerae (HP:0000592)2.26867931
60Myopathic facies (HP:0002058)2.26168382
61Abnormality of the umbilical cord (HP:0010881)2.25467343
62Breech presentation (HP:0001623)2.24995705
63Wormian bones (HP:0002645)2.24588095
64Widely patent fontanelles and sutures (HP:0004492)2.24393218
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.23832941
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23427798
67Multiple enchondromatosis (HP:0005701)2.19816526
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17763374
69Short 1st metacarpal (HP:0010034)2.17763374
70Rough bone trabeculation (HP:0100670)2.17076331
71Pili torti (HP:0003777)2.13342997
72Dilatation of the ascending aorta (HP:0005111)2.10976970
73Shallow orbits (HP:0000586)2.10392225
74Congenital sensorineural hearing impairment (HP:0008527)2.10376508
75Type 1 muscle fiber predominance (HP:0003803)2.09297016
76Abnormality of the aortic arch (HP:0012303)2.08997557
77Nasal polyposis (HP:0100582)2.08034388
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.07347161
79Flat acetabular roof (HP:0003180)2.06978285
80Woolly hair (HP:0002224)2.05711849
81Aplasia/Hypoplasia of the patella (HP:0006498)2.04910130
82Short humerus (HP:0005792)2.04893995
83Osteolytic defects of the hand bones (HP:0009699)2.04865450
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.04865450
85Abnormal number of erythroid precursors (HP:0012131)2.03470506
86Aneurysm (HP:0002617)2.03097253
87Abnormal cartilage morphology (HP:0002763)2.02693226
88Follicular hyperkeratosis (HP:0007502)2.02082058
89Microretrognathia (HP:0000308)2.01547554
90Increased connective tissue (HP:0009025)2.01546224
91Absent radius (HP:0003974)2.00588699
92Patellar aplasia (HP:0006443)2.00506962
93Pustule (HP:0200039)1.99135088
94Short hallux (HP:0010109)1.98950408
95Cerebral aneurysm (HP:0004944)1.98365655
96Protuberant abdomen (HP:0001538)1.96368673
97Growth hormone excess (HP:0000845)1.95547780
98Abnormality of dentin (HP:0010299)1.95256084
99Eczematoid dermatitis (HP:0000976)1.95102224
100Abnormal ventriculo-arterial connection (HP:0011563)1.94883879
101Transposition of the great arteries (HP:0001669)1.94883879
102Abnormal connection of the cardiac segments (HP:0011545)1.94883879
103Spinal cord compression (HP:0002176)1.94702380
104Ureteral duplication (HP:0000073)1.94178235
105Nephrolithiasis (HP:0000787)1.94128280
106Coxa vara (HP:0002812)1.94025644
107Abnormality of the acetabulum (HP:0003170)1.93894940
108Flattened epiphyses (HP:0003071)1.93408898
109Shawl scrotum (HP:0000049)1.92843554
110Neonatal short-limb short stature (HP:0008921)1.92494652
111Secondary amenorrhea (HP:0000869)1.91641391
112Xanthomatosis (HP:0000991)1.90490744
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.89245901
114Hypotension (HP:0002615)1.89133895
115Abnormality of the 2nd finger (HP:0004100)1.88670521
116Fused cervical vertebrae (HP:0002949)1.88020328
117Mesangial abnormality (HP:0001966)1.87574075
118Sparse eyelashes (HP:0000653)1.87029289
119Delayed epiphyseal ossification (HP:0002663)1.87017013
120Distal upper limb amyotrophy (HP:0007149)1.86772955
121Upper limb amyotrophy (HP:0009129)1.86772955
122Osteoarthritis (HP:0002758)1.85368746
123Abnormality of vitamin B metabolism (HP:0004340)1.85170142
124Male infertility (HP:0003251)1.84580908
125Mildly elevated creatine phosphokinase (HP:0008180)1.83458709
126Abnormal delivery (HP:0001787)1.83389146
127Onycholysis (HP:0001806)1.83388996
128Abnormal biliary tract morphology (HP:0012440)1.83357085
129Absent forearm bone (HP:0003953)1.83274680
130Aplasia involving forearm bones (HP:0009822)1.83274680
131Abdominal distention (HP:0003270)1.82517126
132Cervical subluxation (HP:0003308)1.82331554
133Hyperphosphatemia (HP:0002905)1.81677305
134Neoplasm of the pancreas (HP:0002894)1.80828689
135Impulsivity (HP:0100710)1.80827799
136Focal segmental glomerulosclerosis (HP:0000097)1.80643709
137Stridor (HP:0010307)1.80157569
138Joint stiffness (HP:0001387)1.79868292
139Premature ovarian failure (HP:0008209)1.78551492
140Carpal bone hypoplasia (HP:0001498)1.78381285
141Cheilitis (HP:0100825)1.78215248
142Milia (HP:0001056)1.77932163
143Hyperextensible skin (HP:0000974)1.77894572
144Difficulty climbing stairs (HP:0003551)1.77483958
145Nonimmune hydrops fetalis (HP:0001790)1.77218431
146Pterygium (HP:0001059)1.77150484
147Abnormal hair laboratory examination (HP:0003328)1.77110502
148Abnormality of carpal bone ossification (HP:0006257)1.77070604
149Abnormality of chloride homeostasis (HP:0011422)1.76340247
150Abnormality of the phalanges of the hallux (HP:0010057)1.74833207
151Cupped ribs (HP:0000887)1.74698202
152Increased purine levels (HP:0004368)1.74380873
153Hyperuricemia (HP:0002149)1.74380873
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73806361
155Vertebral hypoplasia (HP:0008417)1.73806361
156Pallor (HP:0000980)1.73735838
157Broad metatarsal (HP:0001783)1.73720506
158Cardiovascular calcification (HP:0011915)1.72410829
159Abnormal ossification of hand bones (HP:0005921)1.72401149
160Biliary tract neoplasm (HP:0100574)1.72087006
161Hypophosphatemia (HP:0002148)1.71926600
162Abnormal tarsal ossification (HP:0008369)1.71919191
163Abnormality of the proximal phalanges of the hand (HP:0009834)1.71255505
164Ridged nail (HP:0001807)1.70806165
165Pigmentary retinal degeneration (HP:0001146)1.70751597
166Nail dystrophy (HP:0008404)1.70589627
167Wide cranial sutures (HP:0010537)1.69580665
168Abnormalities of placenta or umbilical cord (HP:0001194)1.69365258
169Hyperaldosteronism (HP:0000859)1.69289195
170Joint laxity (HP:0001388)1.68727869
171Soft skin (HP:0000977)1.66722084
172Thin bony cortex (HP:0002753)1.66262886
173Congenital, generalized hypertrichosis (HP:0004540)1.66261585
174Spinal rigidity (HP:0003306)1.66175999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.58456466
2BUB13.68304723
3MAP2K22.59959418
4LMTK22.50659364
5TESK12.42523516
6WEE12.36132602
7RPS6KB22.26261968
8NME22.21222885
9TTK2.17064139
10MST1R2.13722770
11STK38L2.11927588
12LATS22.08274437
13EPHB21.97819975
14PAK41.93160339
15FGFR41.89298629
16DDR21.83195943
17NME11.82337124
18PIM21.81902780
19FRK1.71534936
20EPHB11.67082432
21NEK21.60857273
22MAP3K111.58496487
23MAP3K31.55374649
24NEK11.53332623
25TESK21.50010658
26MET1.42479795
27EPHA31.41898743
28MAP3K81.38405259
29TGFBR21.37992202
30PLK41.35948177
31SMG11.32388964
32RPS6KA41.29928463
33PRKCI1.29555871
34AURKB1.29124189
35PRKG21.28799730
36LATS11.28112849
37BRAF1.27915896
38AKT31.27562869
39TYK21.27013502
40ZAK1.17224860
41PLK11.17052384
42CDK71.15288410
43MST41.14579979
44MAP3K121.13206733
45SIK11.12644304
46PRPF4B1.11355024
47EIF2AK11.10837359
48ERN11.08672876
49PAK11.04668320
50LIMK11.04525714
51TAOK11.03846761
52STK241.02453390
53TIE10.99903583
54FER0.98568652
55MAP3K10.98084191
56TRIB30.97420205
57MYLK0.97035417
58TAOK20.94135422
59PDGFRA0.93984305
60KDR0.93161942
61PBK0.93150561
62AURKA0.92899161
63TBK10.91644781
64PTK20.91146699
65STK390.89306725
66BRSK20.87728500
67BCKDK0.87416175
68DYRK30.87021595
69ZAP700.86846718
70GRK60.85302912
71PIK3CA0.85008355
72MAP2K10.83680168
73NTRK10.83453801
74ARAF0.82994924
75PRKD20.82349706
76LRRK20.81488905
77SRPK10.81437303
78RIPK10.81298924
79PDPK10.79873197
80CHEK20.74475154
81DMPK0.74218285
82STK100.73897812
83RPS6KA20.73861139
84PDK20.73291134
85MAPKAPK30.71393852
86PKN20.70066387
87PTK60.69407046
88PDK30.68384937
89PDK40.68384937
90MAP3K20.68384212
91NEK90.66645845
92ILK0.66017606
93TLK10.62859020
94STK30.62604463
95ICK0.61570212
96TTN0.61469274
97DAPK30.59454856
98MTOR0.58853250
99CDK120.58560035
100ERBB20.57497887
101KIT0.56243439
102FGFR30.55546904
103RPS6KC10.54242808
104RPS6KL10.54242808
105GRK50.54201473
106MAP2K60.53974541
107CDC70.53585943
108JAK30.53183705
109PAK20.52330886
110TSSK60.51763795
111PLK30.51697039
112BMX0.51640961
113DYRK1B0.51589394
114MAP4K10.51459790
115SRC0.50881262
116MAP3K100.50836238
117IRAK30.50651896
118MAPK70.50071041
119PDGFRB0.49683510
120ABL20.48929972
121STK160.48326048
122MAP3K60.47779920
123ACVR1B0.47363707
124CSK0.46147113
125TYRO30.45965093
126MAP2K30.45891223
127CAMK2G0.45644673
128CDK60.44561516
129AKT20.42774648
130MAPK150.42362608
131KSR20.42124471
132ROCK10.41145640
133MAPK110.39678464
134CSNK2A10.39343373
135RPS6KA60.38686228
136JAK10.37293856
137CHEK10.37277309
138ATR0.37008072
139MATK0.36735160
140CAMK2D0.36680725
141RET0.36426376
142PASK0.35281978
143ROCK20.35233792
144CDC42BPA0.34682509
145PRKCD0.34098034
146EEF2K0.34046591
147MAPKAPK20.32750706
148PRKAA20.29945850
149NLK0.29549122
150PRKCA0.29405666

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.17724042
2Proteasome_Homo sapiens_hsa030503.11168324
3Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.44458211
4Arginine biosynthesis_Homo sapiens_hsa002202.37852678
5DNA replication_Homo sapiens_hsa030302.29717141
6RNA polymerase_Homo sapiens_hsa030202.22076163
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18950670
8Glutathione metabolism_Homo sapiens_hsa004802.17692682
9Mismatch repair_Homo sapiens_hsa034302.15155098
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08538423
11Sulfur metabolism_Homo sapiens_hsa009202.07702734
12Fat digestion and absorption_Homo sapiens_hsa049752.06346591
13RNA transport_Homo sapiens_hsa030132.04065930
14Folate biosynthesis_Homo sapiens_hsa007901.94166125
15Spliceosome_Homo sapiens_hsa030401.92781662
16Fructose and mannose metabolism_Homo sapiens_hsa000511.89822940
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86300270
18Pyrimidine metabolism_Homo sapiens_hsa002401.72361816
19Galactose metabolism_Homo sapiens_hsa000521.66245062
20Mineral absorption_Homo sapiens_hsa049781.66192724
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59845893
22Sulfur relay system_Homo sapiens_hsa041221.56359605
23Asthma_Homo sapiens_hsa053101.56095824
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53066960
25Tight junction_Homo sapiens_hsa045301.49388621
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48655580
27Cell cycle_Homo sapiens_hsa041101.48043322
28Nucleotide excision repair_Homo sapiens_hsa034201.47279153
29Basal cell carcinoma_Homo sapiens_hsa052171.46933024
30Hedgehog signaling pathway_Homo sapiens_hsa043401.46396510
31Hippo signaling pathway_Homo sapiens_hsa043901.45303426
32One carbon pool by folate_Homo sapiens_hsa006701.40920687
33PPAR signaling pathway_Homo sapiens_hsa033201.39814187
34Other glycan degradation_Homo sapiens_hsa005111.39646062
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39071027
36p53 signaling pathway_Homo sapiens_hsa041151.38379685
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33543668
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.32939767
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.31541230
40Bladder cancer_Homo sapiens_hsa052191.31105927
41Oxidative phosphorylation_Homo sapiens_hsa001901.29120550
42Pentose phosphate pathway_Homo sapiens_hsa000301.28373851
43Base excision repair_Homo sapiens_hsa034101.26401938
44Chemical carcinogenesis_Homo sapiens_hsa052041.26310523
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23953373
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23737383
47Huntingtons disease_Homo sapiens_hsa050161.22840009
48Parkinsons disease_Homo sapiens_hsa050121.21988712
49Staphylococcus aureus infection_Homo sapiens_hsa051501.20458631
50Adherens junction_Homo sapiens_hsa045201.19031012
51Renin-angiotensin system_Homo sapiens_hsa046141.15938733
52Bile secretion_Homo sapiens_hsa049761.15299142
53Fatty acid degradation_Homo sapiens_hsa000711.14264871
54Homologous recombination_Homo sapiens_hsa034401.13981095
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.11865792
56Vitamin digestion and absorption_Homo sapiens_hsa049771.11799882
57Arachidonic acid metabolism_Homo sapiens_hsa005901.06754896
58Protein digestion and absorption_Homo sapiens_hsa049741.06476723
59Glycerolipid metabolism_Homo sapiens_hsa005611.03820527
60Allograft rejection_Homo sapiens_hsa053301.03585006
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02204144
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98557223
63TGF-beta signaling pathway_Homo sapiens_hsa043500.98556800
64Thyroid cancer_Homo sapiens_hsa052160.97734861
65Carbon metabolism_Homo sapiens_hsa012000.97652176
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96606911
67Autoimmune thyroid disease_Homo sapiens_hsa053200.96465494
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95689962
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95151917
70Biosynthesis of amino acids_Homo sapiens_hsa012300.93979794
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93914674
72Arginine and proline metabolism_Homo sapiens_hsa003300.93683129
73Pancreatic secretion_Homo sapiens_hsa049720.90633858
74Graft-versus-host disease_Homo sapiens_hsa053320.89440829
75Selenocompound metabolism_Homo sapiens_hsa004500.88763588
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85640325
77Purine metabolism_Homo sapiens_hsa002300.83979813
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83902951
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83454201
80Pertussis_Homo sapiens_hsa051330.82403246
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82072565
82Amoebiasis_Homo sapiens_hsa051460.80594931
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79867689
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.79809158
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79302334
86ECM-receptor interaction_Homo sapiens_hsa045120.72245199
87Linoleic acid metabolism_Homo sapiens_hsa005910.71266351
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71068409
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70545692
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.69241212
91RNA degradation_Homo sapiens_hsa030180.68001268
92Tryptophan metabolism_Homo sapiens_hsa003800.67115061
93mRNA surveillance pathway_Homo sapiens_hsa030150.66225760
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64549868
95Alzheimers disease_Homo sapiens_hsa050100.64150892
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63186633
97Tyrosine metabolism_Homo sapiens_hsa003500.63171453
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62396337
99Small cell lung cancer_Homo sapiens_hsa052220.61078878
100Retinol metabolism_Homo sapiens_hsa008300.60958238
101Type I diabetes mellitus_Homo sapiens_hsa049400.60173711
102Fanconi anemia pathway_Homo sapiens_hsa034600.59768139
103Nitrogen metabolism_Homo sapiens_hsa009100.59315166
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59151855
105Prion diseases_Homo sapiens_hsa050200.58578258
106Leishmaniasis_Homo sapiens_hsa051400.58310917
107Ether lipid metabolism_Homo sapiens_hsa005650.58124482
108Hepatitis C_Homo sapiens_hsa051600.57292503
109Proteoglycans in cancer_Homo sapiens_hsa052050.55035130
110Starch and sucrose metabolism_Homo sapiens_hsa005000.54769339
111Toxoplasmosis_Homo sapiens_hsa051450.54386320
112Viral myocarditis_Homo sapiens_hsa054160.53718109
113Metabolic pathways_Homo sapiens_hsa011000.53670379
114Sphingolipid metabolism_Homo sapiens_hsa006000.52666891
115Complement and coagulation cascades_Homo sapiens_hsa046100.51687398
116Thyroid hormone synthesis_Homo sapiens_hsa049180.50754447
117Basal transcription factors_Homo sapiens_hsa030220.50694679
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49026427
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48702496
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48310364
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47088507
122Histidine metabolism_Homo sapiens_hsa003400.46906550
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46777091
124Antigen processing and presentation_Homo sapiens_hsa046120.46535756
125Caffeine metabolism_Homo sapiens_hsa002320.45740834
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.45394330
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.45347813
128MicroRNAs in cancer_Homo sapiens_hsa052060.45312060
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44382210
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.43123445
131Epstein-Barr virus infection_Homo sapiens_hsa051690.42869303
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42146202
133Phenylalanine metabolism_Homo sapiens_hsa003600.42078585
134HTLV-I infection_Homo sapiens_hsa051660.39185645
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.38713482
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37847130
137Focal adhesion_Homo sapiens_hsa045100.37613522
138Salmonella infection_Homo sapiens_hsa051320.36408787
139Vibrio cholerae infection_Homo sapiens_hsa051100.34180256
140TNF signaling pathway_Homo sapiens_hsa046680.34107235
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32792281
142Pathways in cancer_Homo sapiens_hsa052000.32603620
143Legionellosis_Homo sapiens_hsa051340.31250595
144Wnt signaling pathway_Homo sapiens_hsa043100.30496993
145Renin secretion_Homo sapiens_hsa049240.30213054
146Shigellosis_Homo sapiens_hsa051310.29738757
147Insulin resistance_Homo sapiens_hsa049310.29192620
148Lysosome_Homo sapiens_hsa041420.29063962
149Notch signaling pathway_Homo sapiens_hsa043300.28503215
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.28136812
151Vitamin B6 metabolism_Homo sapiens_hsa007500.28079242
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.27669991
153Phagosome_Homo sapiens_hsa041450.26160345
154Influenza A_Homo sapiens_hsa051640.23535015
155Endocytosis_Homo sapiens_hsa041440.20837167
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19297134
157GnRH signaling pathway_Homo sapiens_hsa049120.17390853
158Tuberculosis_Homo sapiens_hsa051520.17068826

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