CDC42P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.08211802
2regulation of timing of cell differentiation (GO:0048505)5.62215456
3microtubule depolymerization (GO:0007019)5.46837591
4gamma-aminobutyric acid transport (GO:0015812)5.30541387
5regulation of isotype switching to IgG isotypes (GO:0048302)5.27679237
6regulation of MHC class II biosynthetic process (GO:0045346)5.07924123
7neuron fate determination (GO:0048664)5.07679736
8regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.96996070
9positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.96996070
10regulation of podosome assembly (GO:0071801)4.90727595
11regulation of development, heterochronic (GO:0040034)4.81258324
12positive regulation of chemokine biosynthetic process (GO:0045080)4.76283279
13protein complex biogenesis (GO:0070271)4.53553126
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49928340
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.49928340
16NADH dehydrogenase complex assembly (GO:0010257)4.49928340
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.30558851
18regulation of interleukin-6 biosynthetic process (GO:0045408)4.25834142
19regulation of cytokine production involved in inflammatory response (GO:1900015)4.21847408
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15163411
21hepatocyte differentiation (GO:0070365)4.09588138
22mitochondrial respiratory chain complex assembly (GO:0033108)4.07928630
23regulation of interleukin-12 biosynthetic process (GO:0045075)4.02604422
24alpha-beta T cell differentiation involved in immune response (GO:0002293)3.98445582
25alpha-beta T cell activation involved in immune response (GO:0002287)3.98445582
26T cell differentiation involved in immune response (GO:0002292)3.98445582
27regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.96745771
28regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.87777992
29dopaminergic neuron differentiation (GO:0071542)3.86281780
30male sex determination (GO:0030238)3.70624638
31pyrimidine nucleobase catabolic process (GO:0006208)3.59852898
32detection of light stimulus involved in sensory perception (GO:0050962)3.59417553
33detection of light stimulus involved in visual perception (GO:0050908)3.59417553
34negative regulation of metanephros development (GO:0072217)3.56256772
35regulation of vitamin D biosynthetic process (GO:0060556)3.55268145
36positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.53904890
37hematopoietic stem cell proliferation (GO:0071425)3.49960836
38regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.49406649
39response to pheromone (GO:0019236)3.46202288
40sequestering of actin monomers (GO:0042989)3.45144714
41regulation of chemokine biosynthetic process (GO:0045073)3.44764918
42regulation of meiosis I (GO:0060631)3.44202172
43negative regulation of neurological system process (GO:0031645)3.32410141
44neuronal action potential (GO:0019228)3.31836754
45lung-associated mesenchyme development (GO:0060484)3.31160103
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31087247
47microtubule polymerization or depolymerization (GO:0031109)3.28872125
48positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.26657180
49positive regulation of muscle cell apoptotic process (GO:0010661)3.25243879
50retina layer formation (GO:0010842)3.22494488
51somite rostral/caudal axis specification (GO:0032525)3.20934927
52positive regulation of isotype switching (GO:0045830)3.20849689
53negative regulation of cell aging (GO:0090344)3.20630779
54nucleobase catabolic process (GO:0046113)3.15687777
55alpha-beta T cell differentiation (GO:0046632)3.13352647
56defense response to protozoan (GO:0042832)3.13054300
57positive regulation of B cell differentiation (GO:0045579)3.11757273
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11210924
59urinary tract smooth muscle contraction (GO:0014848)3.05311911
60positive regulation of DNA recombination (GO:0045911)3.03595349
61response to dietary excess (GO:0002021)3.00291700
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.94622045
63RNA destabilization (GO:0050779)2.91738799
64dopamine biosynthetic process (GO:0042416)2.91695299
65positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.91483445
66lipid translocation (GO:0034204)2.89292630
67phospholipid translocation (GO:0045332)2.89292630
68cellular response to ATP (GO:0071318)2.88148256
69regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.88008685
70sex determination (GO:0007530)2.86222603
71chaperone-mediated protein transport (GO:0072321)2.86058618
72axon extension involved in axon guidance (GO:0048846)2.85664629
73neuron projection extension involved in neuron projection guidance (GO:1902284)2.85664629
74positive regulation of immunoglobulin production (GO:0002639)2.85483070
75midbrain development (GO:0030901)2.80052325
76mast cell degranulation (GO:0043303)2.80006762
77mast cell activation involved in immune response (GO:0002279)2.80006762
78negative regulation of interleukin-17 production (GO:0032700)2.79828910
79intermediate filament organization (GO:0045109)2.79726087
80negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78478129
81negative regulation of mast cell activation (GO:0033004)2.77356044
82monoubiquitinated protein deubiquitination (GO:0035520)2.74515162
83negative regulation of axon extension (GO:0030517)2.73177122
84regulation of vitamin metabolic process (GO:0030656)2.70055170
85negative regulation of kidney development (GO:0090185)2.68765158
86tyrosine metabolic process (GO:0006570)2.62667321
87respiratory electron transport chain (GO:0022904)2.61951770
88negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.61673192
89positive regulation of meiosis (GO:0045836)2.61150392
90ATP synthesis coupled proton transport (GO:0015986)2.61056620
91energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61056620
92inner mitochondrial membrane organization (GO:0007007)2.57973146
93alkaloid metabolic process (GO:0009820)2.57714672
94primitive streak formation (GO:0090009)2.56426853
95ganglion development (GO:0061548)2.55233750
96positive regulation of meiotic cell cycle (GO:0051446)2.53400228
97electron transport chain (GO:0022900)2.52705387
98protein K6-linked ubiquitination (GO:0085020)2.52005079
99rRNA methylation (GO:0031167)2.51281339
100positive regulation of granulocyte differentiation (GO:0030854)2.50777262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.11898952
2VDR_22108803_ChIP-Seq_LS180_Human3.83845833
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10792901
4GBX2_23144817_ChIP-Seq_PC3_Human3.06269072
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.96847175
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.61340034
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53534485
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52106572
9EWS_26573619_Chip-Seq_HEK293_Human2.51986115
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51056967
11TAF15_26573619_Chip-Seq_HEK293_Human2.47757315
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45965778
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38841060
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34445844
15FUS_26573619_Chip-Seq_HEK293_Human2.24978032
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08338784
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.02965211
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01913265
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93361292
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.92151091
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.90768172
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89287870
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87390054
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85300089
25EZH2_22144423_ChIP-Seq_EOC_Human1.82508083
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82335626
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82313565
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81578138
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81041612
30ZNF274_21170338_ChIP-Seq_K562_Hela1.77681428
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.75243069
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66262945
33CBP_20019798_ChIP-Seq_JUKART_Human1.65790271
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65790271
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.60921813
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.58963518
37REST_21632747_ChIP-Seq_MESCs_Mouse1.55494744
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54777522
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51527027
40RNF2_27304074_Chip-Seq_NSC_Mouse1.50755929
41ELK1_19687146_ChIP-ChIP_HELA_Human1.49315796
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48616153
43P300_19829295_ChIP-Seq_ESCs_Human1.48516980
44MYC_18940864_ChIP-ChIP_HL60_Human1.48058106
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.44960610
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.44327102
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44102536
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.43425962
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42118194
50ER_23166858_ChIP-Seq_MCF-7_Human1.40768748
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40743525
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39857642
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38284879
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.38006517
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36453779
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34541548
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33298092
58AR_25329375_ChIP-Seq_VCAP_Human1.33046628
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32161056
60BCAT_22108803_ChIP-Seq_LS180_Human1.32013436
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31634833
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.31609324
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28813192
64SMAD4_21799915_ChIP-Seq_A2780_Human1.28304872
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26676213
66VDR_23849224_ChIP-Seq_CD4+_Human1.23473149
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22601943
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.21342099
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.20599237
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20148937
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.18006678
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16359279
73TCF4_23295773_ChIP-Seq_U87_Human1.16023568
74STAT3_23295773_ChIP-Seq_U87_Human1.14696564
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14460606
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12823191
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12406282
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11917292
79SOX2_19829295_ChIP-Seq_ESCs_Human1.10642863
80NANOG_19829295_ChIP-Seq_ESCs_Human1.10642863
81P53_22387025_ChIP-Seq_ESCs_Mouse1.09703644
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07749191
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06923254
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06699797
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05705129
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04142721
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03536825
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.02902419
89TP53_18474530_ChIP-ChIP_U2OS_Human1.02792112
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02777287
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02309965
92TCF4_22108803_ChIP-Seq_LS180_Human1.00932468
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00059940
94CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99684560
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99571498
96AR_21572438_ChIP-Seq_LNCaP_Human0.99123028
97RUNX2_22187159_ChIP-Seq_PCA_Human0.98401816
98P300_18555785_Chip-Seq_ESCs_Mouse0.98337370
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.98015870
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97827633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.75727092
2MP0001873_stomach_inflammation5.38172915
3MP0002822_catalepsy4.56039464
4MP0004742_abnormal_vestibular_system2.70454948
5MP0003567_abnormal_fetal_cardiomyocyte2.65270405
6MP0004142_abnormal_muscle_tone2.60725928
7MP0004782_abnormal_surfactant_physiolog2.59840794
8MP0000569_abnormal_digit_pigmentation2.50695972
9MP0005671_abnormal_response_to2.45297439
10MP0003880_abnormal_central_pattern2.42239459
11MP0002102_abnormal_ear_morphology2.39802455
12MP0001835_abnormal_antigen_presentation2.13117998
13MP0006082_CNS_inflammation2.05264734
14MP0005408_hypopigmentation1.99737893
15MP0005646_abnormal_pituitary_gland1.98960916
16MP0008877_abnormal_DNA_methylation1.70115448
17MP0009046_muscle_twitch1.62627237
18MP0005423_abnormal_somatic_nervous1.61099929
19MP0006072_abnormal_retinal_apoptosis1.60720559
20MP0005084_abnormal_gallbladder_morpholo1.60296006
21MP0003806_abnormal_nucleotide_metabolis1.55178785
22MP0001790_abnormal_immune_system1.54182358
23MP0005387_immune_system_phenotype1.54182358
24MP0002837_dystrophic_cardiac_calcinosis1.52792266
25MP0000049_abnormal_middle_ear1.52032366
26MP0003122_maternal_imprinting1.50902929
27MP0003718_maternal_effect1.50518584
28MP0008875_abnormal_xenobiotic_pharmacok1.43596564
29MP0005171_absent_coat_pigmentation1.42697002
30MP0002638_abnormal_pupillary_reflex1.41744590
31MP0002938_white_spotting1.40621957
32MP0002138_abnormal_hepatobiliary_system1.40214450
33MP0003121_genomic_imprinting1.28709516
34MP0001984_abnormal_olfaction1.28203006
35MP0000372_irregular_coat_pigmentation1.25033012
36MP0001485_abnormal_pinna_reflex1.24209226
37MP0001188_hyperpigmentation1.23644461
38MP0008569_lethality_at_weaning1.21817692
39MP0002272_abnormal_nervous_system1.21770830
40MP0002933_joint_inflammation1.20932828
41MP0001293_anophthalmia1.20529971
42MP0001663_abnormal_digestive_system1.15471317
43MP0006276_abnormal_autonomic_nervous1.14675388
44MP0001440_abnormal_grooming_behavior1.11865027
45MP0000490_abnormal_crypts_of1.09683346
46MP0006292_abnormal_olfactory_placode1.07926357
47MP0000631_abnormal_neuroendocrine_gland1.07103855
48MP0003186_abnormal_redox_activity1.05360431
49MP0000427_abnormal_hair_cycle1.03966995
50MP0001486_abnormal_startle_reflex1.03962501
51MP0004270_analgesia1.03234911
52MP0009785_altered_susceptibility_to1.01855210
53MP0002735_abnormal_chemical_nociception1.01803627
54MP0009745_abnormal_behavioral_response1.01727893
55MP0001348_abnormal_lacrimal_gland1.00100637
56MP0004145_abnormal_muscle_electrophysio0.99570348
57MP0002166_altered_tumor_susceptibility0.99342703
58MP0000516_abnormal_urinary_system0.98941031
59MP0005367_renal/urinary_system_phenotyp0.98941031
60MP0006138_congestive_heart_failure0.98851434
61MP0005381_digestive/alimentary_phenotyp0.98486143
62MP0005386_behavior/neurological_phenoty0.98191389
63MP0004924_abnormal_behavior0.98191389
64MP0005551_abnormal_eye_electrophysiolog0.96458991
65MP0008872_abnormal_physiological_respon0.96422193
66MP0004134_abnormal_chest_morphology0.94905864
67MP0001879_abnormal_lymphatic_vessel0.91327111
68MP0002064_seizures0.90468294
69MP0002733_abnormal_thermal_nociception0.88137648
70MP0002210_abnormal_sex_determination0.82100221
71MP0002234_abnormal_pharynx_morphology0.82051642
72MP0010030_abnormal_orbit_morphology0.81991310
73MP0002067_abnormal_sensory_capabilities0.80587987
74MP0004510_myositis0.78953765
75MP0003635_abnormal_synaptic_transmissio0.77916778
76MP0009333_abnormal_splenocyte_physiolog0.77726265
77MP0001800_abnormal_humoral_immune0.77600849
78MP0001764_abnormal_homeostasis0.75154660
79MP0004859_abnormal_synaptic_plasticity0.74681067
80MP0001299_abnormal_eye_distance/0.74327605
81MP0004215_abnormal_myocardial_fiber0.73302984
82MP0008058_abnormal_DNA_repair0.71430938
83MP0001970_abnormal_pain_threshold0.70548734
84MP0003936_abnormal_reproductive_system0.70288178
85MP0003646_muscle_fatigue0.70140752
86MP0005000_abnormal_immune_tolerance0.69648990
87MP0002572_abnormal_emotion/affect_behav0.69221577
88MP0001881_abnormal_mammary_gland0.68775165
89MP0001968_abnormal_touch/_nociception0.68023586
90MP0003724_increased_susceptibility_to0.67627549
91MP0009379_abnormal_foot_pigmentation0.66820375
92MP0003436_decreased_susceptibility_to0.65469518
93MP0000026_abnormal_inner_ear0.65022899
94MP0005595_abnormal_vascular_smooth0.63938517
95MP0003890_abnormal_embryonic-extraembry0.61042048
96MP0004885_abnormal_endolymph0.59798513
97MP0008995_early_reproductive_senescence0.59647523
98MP0005385_cardiovascular_system_phenoty0.58684158
99MP0001544_abnormal_cardiovascular_syste0.58684158
100MP0001905_abnormal_dopamine_level0.58182859

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.84948993
2Hypoplasia of the pons (HP:0012110)4.70783809
3Synostosis involving the elbow (HP:0003938)4.44477948
4Humeroradial synostosis (HP:0003041)4.44477948
5Abnormality of the pons (HP:0007361)4.42139767
6Limb dystonia (HP:0002451)4.36253527
7Acute encephalopathy (HP:0006846)4.22283025
8Acute necrotizing encephalopathy (HP:0006965)3.93294523
9Bradycardia (HP:0001662)3.85997683
10Septo-optic dysplasia (HP:0100842)3.85843656
11Absent septum pellucidum (HP:0001331)3.72992595
12Abnormality of the septum pellucidum (HP:0007375)3.72483439
13Increased hepatocellular lipid droplets (HP:0006565)3.59552715
14Gaze-evoked nystagmus (HP:0000640)3.56399720
15Progressive macrocephaly (HP:0004481)3.55014564
16Mitochondrial inheritance (HP:0001427)3.51566734
17Abnormal mitochondria in muscle tissue (HP:0008316)3.49939247
18Symphalangism affecting the phalanges of the hand (HP:0009773)3.49856045
19Congenital, generalized hypertrichosis (HP:0004540)3.46450230
20Atonic seizures (HP:0010819)3.34516356
21Lipid accumulation in hepatocytes (HP:0006561)3.04548139
22Exertional dyspnea (HP:0002875)3.04139216
23Increased CSF lactate (HP:0002490)3.03963829
24Congenital stationary night blindness (HP:0007642)3.01969509
25Renal Fanconi syndrome (HP:0001994)2.98325129
26Hepatocellular necrosis (HP:0001404)2.97796441
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.69532873
28Aplastic anemia (HP:0001915)2.64298568
29Limb hypertonia (HP:0002509)2.64070696
30Recurrent cutaneous fungal infections (HP:0011370)2.51844760
31Chronic mucocutaneous candidiasis (HP:0002728)2.51844760
32Optic nerve hypoplasia (HP:0000609)2.50711158
33Leukodystrophy (HP:0002415)2.48574815
34Absence seizures (HP:0002121)2.47118712
35Spinal muscular atrophy (HP:0007269)2.46808390
36Fibular aplasia (HP:0002990)2.46591914
37Hyperglycinemia (HP:0002154)2.40969039
38Increased intramyocellular lipid droplets (HP:0012240)2.40088951
39Optic disc pallor (HP:0000543)2.34813865
40Short tibia (HP:0005736)2.31976574
41Mesomelia (HP:0003027)2.31463562
42Constricted visual fields (HP:0001133)2.31051673
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30127065
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.29757902
45Hepatic necrosis (HP:0002605)2.23439698
46Spontaneous abortion (HP:0005268)2.19197677
47Inability to walk (HP:0002540)2.13935928
48Abnormality of lateral ventricle (HP:0030047)2.13697785
49Febrile seizures (HP:0002373)2.13518836
50Adactyly (HP:0009776)2.10152774
51Hyperglycinuria (HP:0003108)2.09288121
52Palpebral edema (HP:0100540)2.07492326
53Abnormality of renal resorption (HP:0011038)2.05639242
54Atrial fibrillation (HP:0005110)2.05477997
55Abnormal rod and cone electroretinograms (HP:0008323)2.01938012
56Gonadotropin excess (HP:0000837)2.01737050
57Increased IgE level (HP:0003212)1.99811741
58Cupped ear (HP:0000378)1.98025564
59Porencephaly (HP:0002132)1.97329841
60Abnormality of the ileum (HP:0001549)1.94716570
61Abnormal pupillary function (HP:0007686)1.94323163
62Dialeptic seizures (HP:0011146)1.93994056
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90749519
64Cerebral edema (HP:0002181)1.90333319
65Pancreatic cysts (HP:0001737)1.88470779
66Degeneration of the lateral corticospinal tracts (HP:0002314)1.87789611
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87789611
68Parakeratosis (HP:0001036)1.86222450
69Amblyopia (HP:0000646)1.86163589
70Deformed tarsal bones (HP:0008119)1.84863366
71Chromsome breakage (HP:0040012)1.84653555
72Abnormality of the anterior horn cell (HP:0006802)1.84481481
73Degeneration of anterior horn cells (HP:0002398)1.84481481
74Respiratory failure (HP:0002878)1.83928996
75Metabolic alkalosis (HP:0200114)1.82984655
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.81584779
77Amniotic constriction ring (HP:0009775)1.80857215
78Abnormality of placental membranes (HP:0011409)1.80857215
79Meckel diverticulum (HP:0002245)1.79199710
80Female pseudohermaphroditism (HP:0010458)1.78546478
81Diastasis recti (HP:0001540)1.78326783
82Increased muscle lipid content (HP:0009058)1.76295605
83Pigmentary retinal degeneration (HP:0001146)1.75793638
84Abnormality of the 2nd finger (HP:0004100)1.75658112
85Primary atrial arrhythmia (HP:0001692)1.73283346
86Progressive cerebellar ataxia (HP:0002073)1.73072234
87Xerostomia (HP:0000217)1.71594390
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70742977
89Concave nail (HP:0001598)1.69187178
90Pancytopenia (HP:0001876)1.67936779
91Chin dimple (HP:0010751)1.67865841
92Cleft eyelid (HP:0000625)1.67726041
93Molar tooth sign on MRI (HP:0002419)1.67560171
94Abnormality of midbrain morphology (HP:0002418)1.67560171
95Abnormality of serine family amino acid metabolism (HP:0010894)1.67501083
96Abnormality of glycine metabolism (HP:0010895)1.67501083
97Growth hormone deficiency (HP:0000824)1.66326727
98Palpitations (HP:0001962)1.66147799
99Woolly hair (HP:0002224)1.65595184
100Large for gestational age (HP:0001520)1.65538193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.02713989
2TAOK33.26698291
3WNK33.11779234
4PINK13.08108144
5BUB12.96643204
6WNK12.90857565
7MAP3K122.86304192
8NME12.49644566
9VRK22.38532236
10MST42.38295324
11TNK22.34898544
12STK162.26185970
13TNIK2.23501122
14TAF12.12763163
15KIT1.99374471
16BMPR1B1.97230194
17FRK1.92898547
18SIK21.82064766
19TLK11.76980519
20WNK41.73769033
21PNCK1.69078501
22PBK1.64090065
23MAPKAPK31.63642091
24TSSK61.60313732
25BRSK21.55054826
26PIK3CG1.52622873
27PLK41.42040048
28VRK11.28876792
29GRK11.22030001
30PLK31.16591908
31OXSR11.11547167
32TRIM281.11178788
33ZAK1.09601813
34MARK11.09130882
35MKNK21.07694635
36MINK11.05247084
37DAPK11.01980399
38DYRK21.01758736
39TYRO31.01696923
40STK391.00774487
41ADRBK20.97595507
42MKNK10.97207440
43CDK80.94925148
44TGFBR10.93985147
45NTRK20.91567278
46EIF2AK30.86192690
47MYLK0.85162631
48CAMK2G0.85124497
49MAP4K20.83043582
50MAP2K60.82911622
51CCNB10.79349084
52CASK0.75111291
53PAK30.73030168
54STK38L0.70546309
55FLT30.65607315
56WEE10.65507095
57FGFR10.65019869
58SRPK10.62076102
59MUSK0.60157759
60INSRR0.59337806
61CHEK20.58275351
62PIK3CA0.56836235
63JAK20.56762191
64MAPKAPK50.55565523
65CSNK1E0.54924541
66PRKCG0.54494872
67AKT30.52675836
68OBSCN0.49479066
69ERBB20.49202140
70ERBB30.48634583
71AURKB0.47044412
72MELK0.46703638
73PRKG10.46594261
74DAPK20.46238774
75STK240.46093446
76PKN20.45294769
77DAPK30.45070883
78MAPK130.44543083
79PKN10.40967044
80CAMK2A0.40829387
81CAMK2B0.39061116
82SYK0.38446917
83MAP3K20.36154636
84CSNK2A20.36105853
85PRKCQ0.35961418
86PRKACA0.35064167
87CAMK2D0.34939656
88PHKG20.34724216
89PHKG10.34724216
90PRKACB0.34013735
91MAP3K40.33280423
92MARK30.33192866
93BCR0.32047591
94CSNK1A10.28532709
95INSR0.28321027
96PRKCE0.27944890
97CDK50.27928345
98PDGFRB0.26621027
99BRSK10.26583107
100CSNK1G10.24615501

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.44004963
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.26379916
3Asthma_Homo sapiens_hsa053103.17706920
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.17686586
5Protein export_Homo sapiens_hsa030602.94147896
6Proteasome_Homo sapiens_hsa030502.85376922
7Oxidative phosphorylation_Homo sapiens_hsa001902.72562968
8Autoimmune thyroid disease_Homo sapiens_hsa053202.72197111
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.60520745
10Ribosome_Homo sapiens_hsa030102.57328509
11Fanconi anemia pathway_Homo sapiens_hsa034602.51183522
12Nicotine addiction_Homo sapiens_hsa050332.49279344
13Parkinsons disease_Homo sapiens_hsa050122.42879235
14Phototransduction_Homo sapiens_hsa047442.27062533
15Basal transcription factors_Homo sapiens_hsa030222.04727757
16Graft-versus-host disease_Homo sapiens_hsa053322.02385058
17Regulation of autophagy_Homo sapiens_hsa041401.95372774
18Cardiac muscle contraction_Homo sapiens_hsa042601.76107399
19Type I diabetes mellitus_Homo sapiens_hsa049401.75247063
20Homologous recombination_Homo sapiens_hsa034401.72806277
21RNA degradation_Homo sapiens_hsa030181.67671854
22Alzheimers disease_Homo sapiens_hsa050101.64833598
23Huntingtons disease_Homo sapiens_hsa050161.52696347
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48950704
25RNA polymerase_Homo sapiens_hsa030201.41064378
26Dorso-ventral axis formation_Homo sapiens_hsa043201.40326565
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32775124
28Folate biosynthesis_Homo sapiens_hsa007901.31283592
29Hematopoietic cell lineage_Homo sapiens_hsa046401.24123510
30Antigen processing and presentation_Homo sapiens_hsa046121.24042347
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21948516
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20735950
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16411522
34Systemic lupus erythematosus_Homo sapiens_hsa053221.15916405
35T cell receptor signaling pathway_Homo sapiens_hsa046601.14221198
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13812813
37Taste transduction_Homo sapiens_hsa047421.13810370
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11163367
39Mineral absorption_Homo sapiens_hsa049781.10388026
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08985304
41Olfactory transduction_Homo sapiens_hsa047401.06015389
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.02976065
43RNA transport_Homo sapiens_hsa030131.01705617
44Leishmaniasis_Homo sapiens_hsa051400.97851535
45Non-homologous end-joining_Homo sapiens_hsa034500.94644890
46Rheumatoid arthritis_Homo sapiens_hsa053230.90397398
47Propanoate metabolism_Homo sapiens_hsa006400.88429892
48Measles_Homo sapiens_hsa051620.86197174
49Cocaine addiction_Homo sapiens_hsa050300.85822026
50GABAergic synapse_Homo sapiens_hsa047270.80252928
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.75100676
52Tyrosine metabolism_Homo sapiens_hsa003500.68010906
53Dopaminergic synapse_Homo sapiens_hsa047280.67402948
54Caffeine metabolism_Homo sapiens_hsa002320.62507447
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61840745
56African trypanosomiasis_Homo sapiens_hsa051430.60682430
57Glutamatergic synapse_Homo sapiens_hsa047240.60422853
58Linoleic acid metabolism_Homo sapiens_hsa005910.59304341
59Vitamin B6 metabolism_Homo sapiens_hsa007500.59137580
60Tryptophan metabolism_Homo sapiens_hsa003800.57998116
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54627868
62Chemical carcinogenesis_Homo sapiens_hsa052040.54609461
63TGF-beta signaling pathway_Homo sapiens_hsa043500.54199262
64Fatty acid biosynthesis_Homo sapiens_hsa000610.53554977
65Mismatch repair_Homo sapiens_hsa034300.53263505
66Melanoma_Homo sapiens_hsa052180.52788078
67Hedgehog signaling pathway_Homo sapiens_hsa043400.51374486
68Butanoate metabolism_Homo sapiens_hsa006500.51344609
69Circadian entrainment_Homo sapiens_hsa047130.49982359
70Nucleotide excision repair_Homo sapiens_hsa034200.48728011
71Salivary secretion_Homo sapiens_hsa049700.45962119
72Calcium signaling pathway_Homo sapiens_hsa040200.45628668
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41076218
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40852320
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40810129
76HIF-1 signaling pathway_Homo sapiens_hsa040660.38318171
77Malaria_Homo sapiens_hsa051440.37695806
78mRNA surveillance pathway_Homo sapiens_hsa030150.37300996
79Serotonergic synapse_Homo sapiens_hsa047260.36443187
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36221800
81Toxoplasmosis_Homo sapiens_hsa051450.34995301
82Morphine addiction_Homo sapiens_hsa050320.34121613
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32094738
84Primary immunodeficiency_Homo sapiens_hsa053400.32065885
85Salmonella infection_Homo sapiens_hsa051320.30855638
86Amphetamine addiction_Homo sapiens_hsa050310.30797575
87Peroxisome_Homo sapiens_hsa041460.30792217
88Alcoholism_Homo sapiens_hsa050340.30496918
89Steroid biosynthesis_Homo sapiens_hsa001000.30321557
90Viral myocarditis_Homo sapiens_hsa054160.30119897
91Purine metabolism_Homo sapiens_hsa002300.29795379
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29637986
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28772440
94Vitamin digestion and absorption_Homo sapiens_hsa049770.27670632
95Epstein-Barr virus infection_Homo sapiens_hsa051690.27539829
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27432762
97Histidine metabolism_Homo sapiens_hsa003400.26672589
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24821924
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24461642
100Pyrimidine metabolism_Homo sapiens_hsa002400.22928331

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