CDC42P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)6.07709838
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.75407392
3actin nucleation (GO:0045010)5.74600793
4positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.67578020
5negative regulation of mast cell activation (GO:0033004)5.19068846
6negative regulation of heart rate (GO:0010459)4.75546643
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61091058
8regulation of isotype switching to IgG isotypes (GO:0048302)4.38213909
9innate immune response in mucosa (GO:0002227)4.34258850
10ATP synthesis coupled proton transport (GO:0015986)4.30132523
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30132523
12cytidine metabolic process (GO:0046087)4.26021436
13cytidine catabolic process (GO:0006216)4.26021436
14cytidine deamination (GO:0009972)4.26021436
15positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.14402568
16positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.13726450
17gamma-aminobutyric acid transport (GO:0015812)4.13158243
18sequestering of actin monomers (GO:0042989)4.12862325
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.12160054
20negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.03616390
21DNA deamination (GO:0045006)3.93400687
22positive regulation of triglyceride lipase activity (GO:0061365)3.90969600
23positive regulation of lipoprotein lipase activity (GO:0051006)3.90969600
24negative regulation of alpha-beta T cell activation (GO:0046636)3.86815495
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.85978754
26respiratory chain complex IV assembly (GO:0008535)3.84632273
27positive regulation of B cell mediated immunity (GO:0002714)3.81672039
28positive regulation of immunoglobulin mediated immune response (GO:0002891)3.81672039
29positive regulation of natural killer cell differentiation (GO:0032825)3.74236154
30positive regulation of immunoglobulin production (GO:0002639)3.72036487
31regulation of timing of cell differentiation (GO:0048505)3.68760211
32positive regulation of isotype switching (GO:0045830)3.58576156
33mucosal immune response (GO:0002385)3.57402417
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.55279732
35regulation of development, heterochronic (GO:0040034)3.52650159
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.52602507
37neuron fate determination (GO:0048664)3.47934682
38ribosomal small subunit assembly (GO:0000028)3.45068972
39negative T cell selection (GO:0043383)3.44149563
40regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.40468222
41regulation of natural killer cell differentiation (GO:0032823)3.39401623
42CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.39391261
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35167639
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35167639
45peptidyl-arginine omega-N-methylation (GO:0035247)3.30959250
46negative regulation of T-helper cell differentiation (GO:0045623)3.29396006
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.29396006
48cytochrome complex assembly (GO:0017004)3.29085933
49regulation of immunoglobulin secretion (GO:0051023)3.26594374
50organ or tissue specific immune response (GO:0002251)3.24679697
51positive regulation of DNA recombination (GO:0045911)3.24340293
52regulation of activation of Janus kinase activity (GO:0010533)3.16657988
53positive regulation of humoral immune response (GO:0002922)3.13602127
54regulation of glucokinase activity (GO:0033131)3.13150252
55regulation of hexokinase activity (GO:1903299)3.13150252
56regulation of cellular amino acid metabolic process (GO:0006521)3.11005345
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06867921
58positive T cell selection (GO:0043368)3.06550255
59cellular response to interleukin-15 (GO:0071350)3.05681415
60regulation of alpha-beta T cell proliferation (GO:0046640)3.04593607
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03932921
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01659482
63protein complex biogenesis (GO:0070271)2.94568419
64peptidyl-arginine N-methylation (GO:0035246)2.94027703
65peptidyl-arginine methylation (GO:0018216)2.94027703
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93103478
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92885982
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92254649
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92254649
70negative regulation of nitric oxide biosynthetic process (GO:0045019)2.89676808
71maturation of SSU-rRNA (GO:0030490)2.88138258
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87373711
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87373711
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87373711
75cytokine production involved in immune response (GO:0002367)2.83088016
76lymphocyte costimulation (GO:0031294)2.82669935
77regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.82320520
78negative regulation of acute inflammatory response (GO:0002674)2.80392091
79respiratory electron transport chain (GO:0022904)2.80343411
80positive regulation of chemokine biosynthetic process (GO:0045080)2.80227982
81electron transport chain (GO:0022900)2.79547690
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76800601
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76730189
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.76730189
85protein-cofactor linkage (GO:0018065)2.76567671
86negative regulation of alpha-beta T cell differentiation (GO:0046639)2.75444738
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.74621255
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72748668
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.72748668
90NADH dehydrogenase complex assembly (GO:0010257)2.72748668
91T-helper cell differentiation (GO:0042093)2.67380809
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.67380809
93positive regulation of granulocyte differentiation (GO:0030854)2.66730644
94cytokine biosynthetic process (GO:0042089)2.65679686
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.64882628
96positive regulation of B cell proliferation (GO:0030890)2.63854041
97T cell receptor signaling pathway (GO:0050852)2.63059889
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62850702
99platelet dense granule organization (GO:0060155)2.60364228
100negative regulation of ligase activity (GO:0051352)2.60210278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78988231
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.64978680
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.84236776
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.30400563
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.39525385
6VDR_22108803_ChIP-Seq_LS180_Human3.22860739
7IRF1_19129219_ChIP-ChIP_H3396_Human2.88372777
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60180636
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36357746
10PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.33441586
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.29376000
12TAF15_26573619_Chip-Seq_HEK293_Human2.23245402
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22966422
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22540989
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.06797114
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05599597
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01907172
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95083843
19VDR_23849224_ChIP-Seq_CD4+_Human1.88276748
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88262377
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79877592
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78722028
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.77036738
24FUS_26573619_Chip-Seq_HEK293_Human1.75275136
25CBP_20019798_ChIP-Seq_JUKART_Human1.72415101
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72415101
27ELK1_19687146_ChIP-ChIP_HELA_Human1.72285659
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71040158
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68213217
30EWS_26573619_Chip-Seq_HEK293_Human1.67712141
31MYC_18940864_ChIP-ChIP_HL60_Human1.58588712
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53319086
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52601373
34ELK1_22589737_ChIP-Seq_MCF10A_Human1.50669402
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47842412
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.47307118
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45271507
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44683024
39NCOR_22424771_ChIP-Seq_293T_Human1.43812626
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42163628
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41499009
42ZNF274_21170338_ChIP-Seq_K562_Hela1.40116527
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.31716866
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30651588
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30610475
46AR_21572438_ChIP-Seq_LNCaP_Human1.27010914
47RNF2_27304074_Chip-Seq_NSC_Mouse1.25826211
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25779581
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25079344
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25021214
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24969784
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23861168
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23719705
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21331998
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20995320
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.20790414
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20790414
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20660273
59P300_19829295_ChIP-Seq_ESCs_Human1.19479778
60SOX2_19829295_ChIP-Seq_ESCs_Human1.19311883
61NANOG_19829295_ChIP-Seq_ESCs_Human1.19311883
62GATA3_26560356_Chip-Seq_TH2_Human1.18907626
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18258663
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18213683
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.16810170
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.15647267
67ERG_20517297_ChIP-Seq_VCAP_Human1.14840389
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14113226
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13116224
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.12979913
71SCL_19346495_ChIP-Seq_HPC-7_Human1.11593084
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11527245
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11015516
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08288545
75HTT_18923047_ChIP-ChIP_STHdh_Human1.07869599
76GBX2_23144817_ChIP-Seq_PC3_Human1.07205471
77FOXP3_21729870_ChIP-Seq_TREG_Human1.05951411
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05711094
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05063736
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05025358
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.04251607
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03451582
83AR_20517297_ChIP-Seq_VCAP_Human1.03142436
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02967582
85NANOG_20526341_ChIP-Seq_ESCs_Human1.01357282
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00089264
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.99756145
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99124607
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99049860
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97894089
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94302076
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93862097
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92951078
94AR_25329375_ChIP-Seq_VCAP_Human0.92552814
95TAF2_19829295_ChIP-Seq_ESCs_Human0.89228970
96ER_23166858_ChIP-Seq_MCF-7_Human0.88211056
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88149196
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87562305
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87323512
100WDR5_24793694_ChIP-Seq_LNCAP_Human0.85963804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.71475832
2MP0005671_abnormal_response_to4.53505696
3MP0000685_abnormal_immune_system3.62179111
4MP0000566_synostosis3.14052936
5MP0002166_altered_tumor_susceptibility3.11296868
6MP0006072_abnormal_retinal_apoptosis3.09400818
7MP0001348_abnormal_lacrimal_gland2.94654514
8MP0002006_tumorigenesis2.82538462
9MP0001873_stomach_inflammation2.75798429
10MP0008875_abnormal_xenobiotic_pharmacok2.68570284
11MP0001835_abnormal_antigen_presentation2.44471825
12MP0009379_abnormal_foot_pigmentation2.42428808
13MP0009785_altered_susceptibility_to2.25049940
14MP0002822_catalepsy2.16431378
15MP0003436_decreased_susceptibility_to2.10982547
16MP0009333_abnormal_splenocyte_physiolog2.09800481
17MP0002009_preneoplasia2.04458732
18MP0003724_increased_susceptibility_to1.88936964
19MP0003806_abnormal_nucleotide_metabolis1.88819175
20MP0003283_abnormal_digestive_organ1.86593175
21MP0008995_early_reproductive_senescence1.81053757
22MP0005646_abnormal_pituitary_gland1.73436751
23MP0008872_abnormal_physiological_respon1.71936545
24MP0005000_abnormal_immune_tolerance1.68860542
25MP0002148_abnormal_hypersensitivity_rea1.55743635
26MP0001800_abnormal_humoral_immune1.55266250
27MP0002102_abnormal_ear_morphology1.51594280
28MP0005387_immune_system_phenotype1.44295252
29MP0001790_abnormal_immune_system1.44295252
30MP0004134_abnormal_chest_morphology1.43060171
31MP0009764_decreased_sensitivity_to1.35986569
32MP0003763_abnormal_thymus_physiology1.35959385
33MP0009745_abnormal_behavioral_response1.35796928
34MP0001905_abnormal_dopamine_level1.33253675
35MP0002272_abnormal_nervous_system1.23901758
36MP0006082_CNS_inflammation1.21759503
37MP0009046_muscle_twitch1.20270519
38MP0005025_abnormal_response_to1.18615849
39MP0005645_abnormal_hypothalamus_physiol1.18578089
40MP0008877_abnormal_DNA_methylation1.17945411
41MP0002638_abnormal_pupillary_reflex1.17848014
42MP0005423_abnormal_somatic_nervous1.16922113
43MP0002095_abnormal_skin_pigmentation1.15461083
44MP0008058_abnormal_DNA_repair1.13014747
45MP0005551_abnormal_eye_electrophysiolog1.10660794
46MP0008057_abnormal_DNA_replication1.10426188
47MP0004145_abnormal_muscle_electrophysio1.08554800
48MP0002723_abnormal_immune_serum1.06768019
49MP0005253_abnormal_eye_physiology1.03355861
50MP0003786_premature_aging1.00789730
51MP0005448_abnormal_energy_balance1.00478388
52MP0000858_altered_metastatic_potential0.99543688
53MP0006054_spinal_hemorrhage0.97865536
54MP0005174_abnormal_tail_pigmentation0.97115003
55MP0003866_abnormal_defecation0.96053248
56MP0006138_congestive_heart_failure0.94347591
57MP0001486_abnormal_startle_reflex0.94011485
58MP0010386_abnormal_urinary_bladder0.92564355
59MP0002452_abnormal_antigen_presenting0.92458708
60MP0002138_abnormal_hepatobiliary_system0.91482726
61MP0004885_abnormal_endolymph0.90836875
62MP0002420_abnormal_adaptive_immunity0.88283355
63MP0001819_abnormal_immune_cell0.87485190
64MP0001533_abnormal_skeleton_physiology0.87106716
65MP0002064_seizures0.86734652
66MP0001188_hyperpigmentation0.86664974
67MP0001765_abnormal_ion_homeostasis0.85604338
68MP0001919_abnormal_reproductive_system0.84631333
69MP0005085_abnormal_gallbladder_physiolo0.83476958
70MP0003646_muscle_fatigue0.83110298
71MP0005389_reproductive_system_phenotype0.81433666
72MP0001485_abnormal_pinna_reflex0.81329563
73MP0001879_abnormal_lymphatic_vessel0.79842240
74MP0006276_abnormal_autonomic_nervous0.78702491
75MP0009643_abnormal_urine_homeostasis0.77510418
76MP0000049_abnormal_middle_ear0.75791342
77MP0002933_joint_inflammation0.74825392
78MP0002693_abnormal_pancreas_physiology0.74585843
79MP0005248_abnormal_Harderian_gland0.73936362
80MP0005310_abnormal_salivary_gland0.73635234
81MP0004859_abnormal_synaptic_plasticity0.73215503
82MP0001119_abnormal_female_reproductive0.72930161
83MP0005166_decreased_susceptibility_to0.71796008
84MP0002557_abnormal_social/conspecific_i0.71538292
85MP0000516_abnormal_urinary_system0.70939687
86MP0005367_renal/urinary_system_phenotyp0.70939687
87MP0008469_abnormal_protein_level0.70085138
88MP0001845_abnormal_inflammatory_respons0.69645508
89MP0003448_altered_tumor_morphology0.66872218
90MP0000639_abnormal_adrenal_gland0.66613797
91MP0005636_abnormal_mineral_homeostasis0.66446360
92MP0002210_abnormal_sex_determination0.66053120
93MP0001501_abnormal_sleep_pattern0.65354936
94MP0002909_abnormal_adrenal_gland0.64988247
95MP0004147_increased_porphyrin_level0.64441535
96MP0001970_abnormal_pain_threshold0.64135875
97MP0000462_abnormal_digestive_system0.63769626
98MP0000604_amyloidosis0.62831554
99MP0001853_heart_inflammation0.62614835
100MP0008569_lethality_at_weaning0.62591169

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.53231416
2Acute encephalopathy (HP:0006846)4.35181546
3Mitochondrial inheritance (HP:0001427)4.26379257
4Increased hepatocellular lipid droplets (HP:0006565)4.21308152
5Progressive macrocephaly (HP:0004481)3.96758167
6Increased CSF lactate (HP:0002490)3.94259411
7Malnutrition (HP:0004395)3.85311903
8Hepatocellular necrosis (HP:0001404)3.74802571
9Abnormal mitochondria in muscle tissue (HP:0008316)3.73272069
10Renal Fanconi syndrome (HP:0001994)3.64512272
11Exertional dyspnea (HP:0002875)3.52688318
12IgG deficiency (HP:0004315)3.51741453
13Lipid accumulation in hepatocytes (HP:0006561)3.46721968
14Hypothermia (HP:0002045)3.45600022
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41058712
16Stomatitis (HP:0010280)3.31491584
17Limb hypertonia (HP:0002509)3.23603850
18Congenital stationary night blindness (HP:0007642)3.19638785
19Steatorrhea (HP:0002570)3.14730484
20Synostosis involving the elbow (HP:0003938)3.03699223
21Humeroradial synostosis (HP:0003041)3.03699223
22Hepatic necrosis (HP:0002605)2.97428215
23Increased intramyocellular lipid droplets (HP:0012240)2.96150368
24Hypoproteinemia (HP:0003075)2.90934197
25Aplastic anemia (HP:0001915)2.86335121
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.84863032
27Symphalangism affecting the phalanges of the hand (HP:0009773)2.68353900
28Atonic seizures (HP:0010819)2.63758926
29Congenital, generalized hypertrichosis (HP:0004540)2.55635480
30Cerebral edema (HP:0002181)2.54675380
31Spontaneous abortion (HP:0005268)2.53811367
32Prostate neoplasm (HP:0100787)2.51381576
33Aplasia/Hypoplasia involving the musculature (HP:0001460)2.50762252
34Metaphyseal dysplasia (HP:0100255)2.47333043
35Fat malabsorption (HP:0002630)2.44541992
36Leukodystrophy (HP:0002415)2.42467230
37Optic disc pallor (HP:0000543)2.42077272
38Bundle branch block (HP:0011710)2.41315059
39Radial bowing (HP:0002986)2.39544701
40Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38868154
41Increased serum lactate (HP:0002151)2.36099210
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.30451048
43Depressed nasal tip (HP:0000437)2.30325731
44Meckel diverticulum (HP:0002245)2.29829373
45Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.27478696
46Bradycardia (HP:0001662)2.26415120
47Lactic acidosis (HP:0003128)2.26163783
48Increased muscle lipid content (HP:0009058)2.25528676
49Abnormality of renal resorption (HP:0011038)2.25420071
50Abnormality of the phalanges of the 5th finger (HP:0004213)2.24490481
51Abnormality of the prostate (HP:0008775)2.24310291
52Attenuation of retinal blood vessels (HP:0007843)2.19775085
53Abnormality of the ileum (HP:0001549)2.19458166
54Respiratory difficulties (HP:0002880)2.17297677
55Rhinitis (HP:0012384)2.16819312
56Congenital ichthyosiform erythroderma (HP:0007431)2.14463606
57Hypoalbuminemia (HP:0003073)2.14410613
58Abnormal albumin level (HP:0012116)2.14410613
59Increased IgM level (HP:0003496)2.12610240
60Diastasis recti (HP:0001540)2.12381295
61Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11653866
62Hyperphosphaturia (HP:0003109)2.10230004
63Severe combined immunodeficiency (HP:0004430)2.10221833
64Abnormality of the preputium (HP:0100587)2.10216023
65Glycosuria (HP:0003076)2.05432106
66Abnormality of urine glucose concentration (HP:0011016)2.05432106
67Severe muscular hypotonia (HP:0006829)2.02213430
68Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97774810
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97774810
70Decreased circulating renin level (HP:0003351)1.96002804
71Gonadotropin excess (HP:0000837)1.94991459
72Abnormality of chromosome stability (HP:0003220)1.91695298
73Respiratory failure (HP:0002878)1.90188310
74Abnormality of T cell number (HP:0011839)1.90001695
75Stenosis of the external auditory canal (HP:0000402)1.89095878
76Hypoglycemic seizures (HP:0002173)1.88836519
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88123025
78Abnormality of the axillary hair (HP:0100134)1.87760674
79Abnormality of secondary sexual hair (HP:0009888)1.87760674
80Inability to walk (HP:0002540)1.87698591
81Rectovaginal fistula (HP:0000143)1.87361658
82Rectal fistula (HP:0100590)1.87361658
83Generalized aminoaciduria (HP:0002909)1.86472370
84Sex reversal (HP:0012245)1.85818492
85Abnormal sex determination (HP:0012244)1.85818492
86Palpitations (HP:0001962)1.85071846
87Absent septum pellucidum (HP:0001331)1.83753882
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83185201
89Abnormality of alanine metabolism (HP:0010916)1.83185201
90Hyperalaninemia (HP:0003348)1.83185201
91Abnormal rod and cone electroretinograms (HP:0008323)1.82781633
92Hypoplasia of the pons (HP:0012110)1.82587950
93Short tibia (HP:0005736)1.79692603
94Pancreatic cysts (HP:0001737)1.78900285
95Exercise intolerance (HP:0003546)1.77883346
96Septo-optic dysplasia (HP:0100842)1.76149339
973-Methylglutaconic aciduria (HP:0003535)1.76065552
98Abnormality of the pons (HP:0007361)1.74503216
99Azoospermia (HP:0000027)1.74209972
100Chorioretinal atrophy (HP:0000533)1.73600157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.69734502
2MAP3K123.64721266
3MUSK3.37342361
4KDR3.12070189
5TAOK32.93457294
6CDK192.81447992
7TRIM282.62185264
8MAPKAPK32.58584503
9PINK12.27964329
10VRK22.19394475
11TSSK62.17169320
12STK162.10253501
13ZAK2.10243554
14BMPR21.95955994
15VRK11.88910200
16SIK21.81095985
17OXSR11.76512089
18NUAK11.69862363
19BUB11.67535252
20MYLK1.64850664
21SRPK11.61256197
22GRK11.54674670
23PBK1.44102455
24MST41.42280575
25NME11.39230733
26BCKDK1.34306115
27MAP3K41.28965243
28PIM21.27276175
29TXK1.22490294
30EPHA31.20733694
31PASK1.17949010
32RPS6KA51.12743891
33ITK1.12065510
34WNK11.08865896
35JAK31.08512043
36GRK71.06700809
37DAPK30.99479420
38CSNK1G30.99110897
39MAP2K70.98117409
40DYRK20.97108216
41MAPK70.93904213
42TESK20.91523559
43STK390.91457317
44DAPK10.90402866
45INSRR0.89844425
46BTK0.89744629
47WNK30.87571403
48SIK30.86842251
49TNK20.82566016
50CSNK1G10.81820308
51PIM10.81254428
52GRK60.79938783
53CSNK1G20.78848019
54PAK40.75725156
55CDK30.74314290
56PRKCG0.72914452
57ERBB30.72327573
58JAK10.70953395
59SYK0.69130989
60IKBKB0.68332177
61CSNK1A1L0.67445282
62LCK0.66861364
63ADRBK20.66568729
64MAPKAPK20.65511807
65LATS10.64609820
66CDK80.63302453
67PHKG10.58205631
68PHKG20.58205631
69MARK10.57355190
70EPHB10.57261963
71FRK0.57049750
72BCR0.53251603
73CAMK2G0.50587708
74PRKG10.49806719
75MAP4K20.49160872
76PAK10.48159481
77MAP3K50.48022589
78OBSCN0.46814503
79WNK40.46767297
80RPS6KA10.46112571
81MAPK130.44273698
82ABL10.43293951
83TESK10.43107335
84TGFBR10.42163706
85ZAP700.41015940
86FLT30.40282583
87TNIK0.39200934
88TIE10.38870534
89FER0.38578133
90ROCK10.38519883
91MKNK20.38129759
92HCK0.36652568
93NLK0.35883782
94IKBKE0.33929453
95CASK0.32426904
96ACVR1B0.31269637
97JAK20.31006949
98CHUK0.30979721
99MAPKAPK50.29600052
100CAMK2A0.28382301

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.29858737
2Allograft rejection_Homo sapiens_hsa053304.19870932
3Autoimmune thyroid disease_Homo sapiens_hsa053204.07863395
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.62677302
5Proteasome_Homo sapiens_hsa030503.53903523
6Systemic lupus erythematosus_Homo sapiens_hsa053223.15886673
7Oxidative phosphorylation_Homo sapiens_hsa001903.01063676
8Type I diabetes mellitus_Homo sapiens_hsa049402.84859001
9Graft-versus-host disease_Homo sapiens_hsa053322.76044689
10Ribosome_Homo sapiens_hsa030102.73014126
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35671264
12Parkinsons disease_Homo sapiens_hsa050122.34960605
13Hematopoietic cell lineage_Homo sapiens_hsa046402.16548796
14Antigen processing and presentation_Homo sapiens_hsa046121.97162314
15Viral myocarditis_Homo sapiens_hsa054161.86921765
16Primary immunodeficiency_Homo sapiens_hsa053401.79112811
17RNA polymerase_Homo sapiens_hsa030201.73002456
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55718830
19Huntingtons disease_Homo sapiens_hsa050161.53204698
20Alzheimers disease_Homo sapiens_hsa050101.51421039
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47825884
22Cardiac muscle contraction_Homo sapiens_hsa042601.46618211
23Alcoholism_Homo sapiens_hsa050341.45883415
24Rheumatoid arthritis_Homo sapiens_hsa053231.45706115
25Phototransduction_Homo sapiens_hsa047441.43092643
26Leishmaniasis_Homo sapiens_hsa051401.29138473
27Protein export_Homo sapiens_hsa030601.27907676
28Staphylococcus aureus infection_Homo sapiens_hsa051501.23362605
29Nitrogen metabolism_Homo sapiens_hsa009101.23046720
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21835979
31Basal transcription factors_Homo sapiens_hsa030221.20085328
32T cell receptor signaling pathway_Homo sapiens_hsa046601.16204463
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06358618
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04682530
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04462370
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01003834
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94882485
38Nicotine addiction_Homo sapiens_hsa050330.89342880
39RNA degradation_Homo sapiens_hsa030180.89168253
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.89021990
41One carbon pool by folate_Homo sapiens_hsa006700.81943181
42Fanconi anemia pathway_Homo sapiens_hsa034600.81029429
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75737099
44Collecting duct acid secretion_Homo sapiens_hsa049660.71505038
45Taste transduction_Homo sapiens_hsa047420.71010362
46Herpes simplex infection_Homo sapiens_hsa051680.70966833
47Malaria_Homo sapiens_hsa051440.68330132
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67730385
49Phagosome_Homo sapiens_hsa041450.66696983
50Regulation of autophagy_Homo sapiens_hsa041400.65994094
51Toxoplasmosis_Homo sapiens_hsa051450.61913392
52Viral carcinogenesis_Homo sapiens_hsa052030.58834628
53Chemical carcinogenesis_Homo sapiens_hsa052040.57786932
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.57405084
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55163520
56Homologous recombination_Homo sapiens_hsa034400.54864272
57Epstein-Barr virus infection_Homo sapiens_hsa051690.54766841
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53808412
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.50882796
60Measles_Homo sapiens_hsa051620.49145096
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.46920086
62Butanoate metabolism_Homo sapiens_hsa006500.46554552
63GABAergic synapse_Homo sapiens_hsa047270.45896197
64Olfactory transduction_Homo sapiens_hsa047400.45455251
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44326503
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43365235
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42258527
68Linoleic acid metabolism_Homo sapiens_hsa005910.39226974
69Salivary secretion_Homo sapiens_hsa049700.37732759
70Mismatch repair_Homo sapiens_hsa034300.36732445
71Morphine addiction_Homo sapiens_hsa050320.33309474
72Pyrimidine metabolism_Homo sapiens_hsa002400.31185044
73Propanoate metabolism_Homo sapiens_hsa006400.30497975
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30430341
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29821403
76Fat digestion and absorption_Homo sapiens_hsa049750.29802371
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28783787
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28207540
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.27793266
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27643428
81Purine metabolism_Homo sapiens_hsa002300.27188646
82Legionellosis_Homo sapiens_hsa051340.25401698
83Caffeine metabolism_Homo sapiens_hsa002320.24675512
84Tuberculosis_Homo sapiens_hsa051520.22574122
85HTLV-I infection_Homo sapiens_hsa051660.21412368
86Tryptophan metabolism_Homo sapiens_hsa003800.21093883
87Influenza A_Homo sapiens_hsa051640.20772227
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18146439
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18145405
90RNA transport_Homo sapiens_hsa030130.18051697
91Circadian entrainment_Homo sapiens_hsa047130.18028310
92Metabolic pathways_Homo sapiens_hsa011000.18020693
93Vibrio cholerae infection_Homo sapiens_hsa051100.12723660
94Retinol metabolism_Homo sapiens_hsa008300.12705789
95N-Glycan biosynthesis_Homo sapiens_hsa005100.11969387
96Dopaminergic synapse_Homo sapiens_hsa047280.11829388
97Dorso-ventral axis formation_Homo sapiens_hsa043200.11796431
98Renin-angiotensin system_Homo sapiens_hsa046140.11771567
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11457688
100Salmonella infection_Homo sapiens_hsa051320.10220601

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