CDC42P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)8.19135539
2regulation of isotype switching to IgG isotypes (GO:0048302)5.88684190
3positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.58986630
4alpha-beta T cell differentiation involved in immune response (GO:0002293)4.70723840
5alpha-beta T cell activation involved in immune response (GO:0002287)4.70723840
6T cell differentiation involved in immune response (GO:0002292)4.70723840
7rRNA modification (GO:0000154)4.66990984
8rRNA methylation (GO:0031167)4.60749332
9regulation of podosome assembly (GO:0071801)4.46539318
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.44392226
11regulation of MHC class II biosynthetic process (GO:0045346)4.35225815
12positive regulation of B cell mediated immunity (GO:0002714)4.29128614
13positive regulation of immunoglobulin mediated immune response (GO:0002891)4.29128614
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.25658619
15positive regulation of humoral immune response (GO:0002922)4.21476073
16positive regulation of chemokine biosynthetic process (GO:0045080)4.12279578
17CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.10306143
18regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.02200413
19positive regulation of isotype switching (GO:0045830)4.01920754
20positive regulation of DNA recombination (GO:0045911)3.98573386
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.97692038
22CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.90665938
23T-helper cell differentiation (GO:0042093)3.90665938
24water-soluble vitamin biosynthetic process (GO:0042364)3.87573608
25proteasome assembly (GO:0043248)3.83787391
26alpha-beta T cell differentiation (GO:0046632)3.77150050
27cellular ketone body metabolic process (GO:0046950)3.70484181
28regulation of immunoglobulin secretion (GO:0051023)3.63845901
29regulation of cellular amino acid metabolic process (GO:0006521)3.63384697
30DNA deamination (GO:0045006)3.60732605
31respiratory chain complex IV assembly (GO:0008535)3.60419677
32termination of RNA polymerase III transcription (GO:0006386)3.59379835
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.59379835
34regulation of growth of symbiont in host (GO:0044126)3.54080108
35negative regulation of growth of symbiont in host (GO:0044130)3.54080108
36negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.54080108
37modulation of growth of symbiont involved in interaction with host (GO:0044144)3.54080108
38ATP synthesis coupled proton transport (GO:0015986)3.50184262
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50184262
40regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.47718134
41positive regulation of immunoglobulin production (GO:0002639)3.40392653
42somite rostral/caudal axis specification (GO:0032525)3.40039286
43pseudouridine synthesis (GO:0001522)3.38716408
44negative regulation of acute inflammatory response (GO:0002674)3.37331340
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.36696673
46negative regulation of T-helper cell differentiation (GO:0045623)3.36696673
47signal peptide processing (GO:0006465)3.34222170
48protein neddylation (GO:0045116)3.33383535
49maturation of 5.8S rRNA (GO:0000460)3.31019443
50alpha-beta T cell activation (GO:0046631)3.30540504
51lymph node development (GO:0048535)3.27033148
52ketone body metabolic process (GO:1902224)3.25748519
53negative regulation of neurological system process (GO:0031645)3.24236477
54positive regulation of histone H3-K4 methylation (GO:0051571)3.18569455
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17321703
56activated T cell proliferation (GO:0050798)3.11183462
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10716359
58protein complex biogenesis (GO:0070271)3.07758713
59cellular response to interleukin-15 (GO:0071350)3.05924173
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04375928
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03418174
62defense response to protozoan (GO:0042832)3.01255537
63CTP metabolic process (GO:0046036)3.01143314
64CTP biosynthetic process (GO:0006241)3.01143314
65cytochrome complex assembly (GO:0017004)2.99265150
66GTP biosynthetic process (GO:0006183)2.98797855
67L-fucose metabolic process (GO:0042354)2.97797430
68L-fucose catabolic process (GO:0042355)2.97797430
69fucose catabolic process (GO:0019317)2.97797430
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97321049
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97321049
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97321049
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95662093
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95662093
75positive regulation of granulocyte differentiation (GO:0030854)2.95065095
76DNA double-strand break processing (GO:0000729)2.93663433
77interferon-gamma production (GO:0032609)2.92180360
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91214029
79positive regulation of organelle assembly (GO:1902117)2.90512289
80mitochondrial respiratory chain complex assembly (GO:0033108)2.90049404
81regulation of inflammatory response to antigenic stimulus (GO:0002861)2.89910308
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89653964
83transcription elongation from RNA polymerase I promoter (GO:0006362)2.89585596
84regulation of interleukin-12 biosynthetic process (GO:0045075)2.88252165
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.87010131
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85834403
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85834403
88isotype switching (GO:0045190)2.85834403
89tRNA processing (GO:0008033)2.84743183
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.84278262
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83981071
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.83981071
93cytokine biosynthetic process (GO:0042089)2.83444772
94regulation of vitamin D biosynthetic process (GO:0060556)2.83184558
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82579111
96cytidine deamination (GO:0009972)2.82573861
97cytidine metabolic process (GO:0046087)2.82573861
98cytidine catabolic process (GO:0006216)2.82573861
99adenosine metabolic process (GO:0046085)2.80785386
100signal transduction involved in cell cycle checkpoint (GO:0072395)2.79504210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27428390
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.99650144
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98262666
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.46948807
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24275889
6VDR_22108803_ChIP-Seq_LS180_Human3.05775519
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.91946798
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84134218
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64752968
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64686010
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.55078715
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43160965
13VDR_23849224_ChIP-Seq_CD4+_Human2.41526109
14IGF1R_20145208_ChIP-Seq_DFB_Human2.26391150
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.23663498
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23572979
17ZNF274_21170338_ChIP-Seq_K562_Hela2.18810271
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.15840383
19ELK1_19687146_ChIP-ChIP_HELA_Human2.01177196
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95018868
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95016256
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93532715
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92651988
24EWS_26573619_Chip-Seq_HEK293_Human1.86603155
25FOXP3_21729870_ChIP-Seq_TREG_Human1.81659931
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78613779
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76465482
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64739014
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63739465
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.61988885
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60364117
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56165644
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54628377
34TAF15_26573619_Chip-Seq_HEK293_Human1.52799255
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49278582
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46603613
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45821976
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45566569
39P300_19829295_ChIP-Seq_ESCs_Human1.45209853
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43114711
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39657655
42FUS_26573619_Chip-Seq_HEK293_Human1.38832851
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38239917
44TP53_22573176_ChIP-Seq_HFKS_Human1.37053439
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33834850
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33566955
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32221693
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.31947167
49GATA3_26560356_Chip-Seq_TH2_Human1.30827276
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.30255244
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28624006
52ER_23166858_ChIP-Seq_MCF-7_Human1.28389602
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26175464
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.26175464
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24814791
56HTT_18923047_ChIP-ChIP_STHdh_Human1.24584760
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.23567169
58SOX2_19829295_ChIP-Seq_ESCs_Human1.23264817
59NANOG_19829295_ChIP-Seq_ESCs_Human1.23264817
60GBX2_23144817_ChIP-Seq_PC3_Human1.21063680
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20896839
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.20734701
63MYC_18940864_ChIP-ChIP_HL60_Human1.17185836
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13889937
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.12534093
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.12359168
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.10600268
68TCF4_22108803_ChIP-Seq_LS180_Human1.09398633
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07972354
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06488955
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05993912
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.04335539
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04139759
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03482628
75HOXB7_26014856_ChIP-Seq_BT474_Human1.03330813
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03047728
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02043697
78P300_18555785_Chip-Seq_ESCs_Mouse1.01780441
79P53_22387025_ChIP-Seq_ESCs_Mouse1.01497502
80AR_20517297_ChIP-Seq_VCAP_Human0.98658254
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.97128432
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97079345
83GABP_19822575_ChIP-Seq_HepG2_Human0.96985297
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96384855
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96134988
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95869038
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.95739752
88E2F1_18555785_Chip-Seq_ESCs_Mouse0.95558699
89SOX2_18555785_Chip-Seq_ESCs_Mouse0.95257516
90MYB_26560356_Chip-Seq_TH2_Human0.95106896
91PHF8_20622853_ChIP-Seq_HELA_Human0.94889673
92STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94541524
93CMYC_18555785_Chip-Seq_ESCs_Mouse0.94463339
94NCOR_22424771_ChIP-Seq_293T_Human0.94454095
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.94369333
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94082454
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93761673
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93629767
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92988461
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92901533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.58577040
2MP0001835_abnormal_antigen_presentation3.72024245
3MP0005671_abnormal_response_to3.50226968
4MP0000685_abnormal_immune_system3.35438542
5MP0001348_abnormal_lacrimal_gland3.02009253
6MP0002254_reproductive_system_inflammat2.97165550
7MP0008875_abnormal_xenobiotic_pharmacok2.87795197
8MP0005645_abnormal_hypothalamus_physiol2.84266535
9MP0005387_immune_system_phenotype2.83183601
10MP0001790_abnormal_immune_system2.83183601
11MP0009785_altered_susceptibility_to2.73962159
12MP0001501_abnormal_sleep_pattern2.39587783
13MP0010386_abnormal_urinary_bladder2.39370986
14MP0009333_abnormal_splenocyte_physiolog2.31549841
15MP0008877_abnormal_DNA_methylation2.24495864
16MP0002166_altered_tumor_susceptibility2.22806540
17MP0008872_abnormal_physiological_respon2.21764602
18MP0003436_decreased_susceptibility_to2.10750058
19MP0005310_abnormal_salivary_gland2.10086262
20MP0002006_tumorigenesis2.09617618
21MP0005084_abnormal_gallbladder_morpholo1.98678235
22MP0002138_abnormal_hepatobiliary_system1.98321740
23MP0002148_abnormal_hypersensitivity_rea1.88637512
24MP0005379_endocrine/exocrine_gland_phen1.83015737
25MP0003646_muscle_fatigue1.82797410
26MP0008058_abnormal_DNA_repair1.82435131
27MP0001800_abnormal_humoral_immune1.67533123
28MP0004142_abnormal_muscle_tone1.66050506
29MP0003186_abnormal_redox_activity1.61591149
30MP0000372_irregular_coat_pigmentation1.61319652
31MP0002163_abnormal_gland_morphology1.59881167
32MP0005000_abnormal_immune_tolerance1.57169947
33MP0002693_abnormal_pancreas_physiology1.55295662
34MP0003195_calcinosis1.54267268
35MP0002102_abnormal_ear_morphology1.51882821
36MP0008057_abnormal_DNA_replication1.42404253
37MP0005075_abnormal_melanosome_morpholog1.40963048
38MP0002139_abnormal_hepatobiliary_system1.39119843
39MP0002837_dystrophic_cardiac_calcinosis1.39030524
40MP0003763_abnormal_thymus_physiology1.38115894
41MP0006072_abnormal_retinal_apoptosis1.29944524
42MP0002405_respiratory_system_inflammati1.24701484
43MP0005646_abnormal_pituitary_gland1.22878223
44MP0006082_CNS_inflammation1.22151306
45MP0001944_abnormal_pancreas_morphology1.17497758
46MP0000427_abnormal_hair_cycle1.15492271
47MP0009764_decreased_sensitivity_to1.15457022
48MP0002723_abnormal_immune_serum1.14516944
49MP0005085_abnormal_gallbladder_physiolo1.10702763
50MP0004043_abnormal_pH_regulation1.05870510
51MP0005025_abnormal_response_to1.05678917
52MP0003866_abnormal_defecation1.05135640
53MP0002272_abnormal_nervous_system1.03922205
54MP0005083_abnormal_biliary_tract1.02724717
55MP0003283_abnormal_digestive_organ1.02465616
56MP0010155_abnormal_intestine_physiology0.98278336
57MP0001845_abnormal_inflammatory_respons0.94391021
58MP0005165_increased_susceptibility_to0.93623111
59MP0001663_abnormal_digestive_system0.92529807
60MP0003786_premature_aging0.91526670
61MP0002420_abnormal_adaptive_immunity0.90168528
62MP0001819_abnormal_immune_cell0.89156055
63MP0001984_abnormal_olfaction0.87612517
64MP0005636_abnormal_mineral_homeostasis0.87015297
65MP0004885_abnormal_endolymph0.86846653
66MP0002452_abnormal_antigen_presenting0.86262260
67MP0001905_abnormal_dopamine_level0.85149005
68MP0001970_abnormal_pain_threshold0.83984114
69MP0001764_abnormal_homeostasis0.83389078
70MP0004145_abnormal_muscle_electrophysio0.83224549
71MP0005448_abnormal_energy_balance0.82170140
72MP0001666_abnormal_nutrient_absorption0.81661559
73MP0004147_increased_porphyrin_level0.81297743
74MP0005389_reproductive_system_phenotype0.80457793
75MP0005551_abnormal_eye_electrophysiolog0.80271508
76MP0001919_abnormal_reproductive_system0.80104279
77MP0002638_abnormal_pupillary_reflex0.79562254
78MP0003806_abnormal_nucleotide_metabolis0.79359599
79MP0004215_abnormal_myocardial_fiber0.79006859
80MP0002938_white_spotting0.77285411
81MP0000689_abnormal_spleen_morphology0.76930418
82MP0004133_heterotaxia0.76622366
83MP0006036_abnormal_mitochondrial_physio0.76550194
84MP0002933_joint_inflammation0.76502423
85MP0002876_abnormal_thyroid_physiology0.76190633
86MP0002909_abnormal_adrenal_gland0.74802933
87MP0001968_abnormal_touch/_nociception0.74645763
88MP0003936_abnormal_reproductive_system0.73779018
89MP0002733_abnormal_thermal_nociception0.73709701
90MP0001881_abnormal_mammary_gland0.73177666
91MP0005332_abnormal_amino_acid0.73083941
92MP0005381_digestive/alimentary_phenotyp0.72802596
93MP0009745_abnormal_behavioral_response0.71157957
94MP0005365_abnormal_bile_salt0.70803541
95MP0004957_abnormal_blastocyst_morpholog0.69677573
96MP0008995_early_reproductive_senescence0.68796884
97MP0005220_abnormal_exocrine_pancreas0.68726900
98MP0002736_abnormal_nociception_after0.68483134
99MP0001756_abnormal_urination0.67181672
100MP0000703_abnormal_thymus_morphology0.66215671

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.64547941
2Acute necrotizing encephalopathy (HP:0006965)4.96753269
3Acute encephalopathy (HP:0006846)4.46990610
4Increased hepatocellular lipid droplets (HP:0006565)4.35089383
5Increased CSF lactate (HP:0002490)4.34390486
6Progressive macrocephaly (HP:0004481)4.31544484
7Lipid accumulation in hepatocytes (HP:0006561)4.21691872
8Abnormal mitochondria in muscle tissue (HP:0008316)4.03639262
9Mitochondrial inheritance (HP:0001427)3.92876486
10Methylmalonic acidemia (HP:0002912)3.66997935
11Renal Fanconi syndrome (HP:0001994)3.62097656
12IgG deficiency (HP:0004315)3.48345201
13Methylmalonic aciduria (HP:0012120)3.13791995
14Cerebral edema (HP:0002181)3.04398559
15Increased serum lactate (HP:0002151)3.03099890
163-Methylglutaconic aciduria (HP:0003535)3.02016525
17Large for gestational age (HP:0001520)3.01297888
18Hepatocellular necrosis (HP:0001404)2.99538246
19Abnormality of vitamin B metabolism (HP:0004340)2.95397393
20Abnormality of the renal cortex (HP:0011035)2.94689511
21Renal cortical cysts (HP:0000803)2.88553543
22Abnormality of methionine metabolism (HP:0010901)2.86176642
23Optic disc pallor (HP:0000543)2.84297951
24Exertional dyspnea (HP:0002875)2.83027744
25Hepatic necrosis (HP:0002605)2.82572292
26Abnormal albumin level (HP:0012116)2.71729526
27Hypoalbuminemia (HP:0003073)2.71729526
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64639742
29Congenital stationary night blindness (HP:0007642)2.62996258
30Hypoproteinemia (HP:0003075)2.55149158
31Lethargy (HP:0001254)2.48879244
32Abnormality of the pons (HP:0007361)2.48542102
33Elevated erythrocyte sedimentation rate (HP:0003565)2.44860283
34Abnormality of the vitamin B12 metabolism (HP:0004341)2.43462092
35Hypoplasia of the pons (HP:0012110)2.41917655
36Respiratory failure (HP:0002878)2.38333633
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37652558
38Tongue fasciculations (HP:0001308)2.36815099
39Abnormality of urine glucose concentration (HP:0011016)2.33873670
40Glycosuria (HP:0003076)2.33873670
41Aplastic anemia (HP:0001915)2.33231486
42Pancreatic cysts (HP:0001737)2.33213210
43Chronic diarrhea (HP:0002028)2.32770901
44Hyperalaninemia (HP:0003348)2.31677143
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31677143
46Abnormality of alanine metabolism (HP:0010916)2.31677143
47Ketoacidosis (HP:0001993)2.30323154
48Hypothermia (HP:0002045)2.30257711
49Nephronophthisis (HP:0000090)2.29384295
50Molar tooth sign on MRI (HP:0002419)2.23930415
51Abnormality of midbrain morphology (HP:0002418)2.23930415
52Lactic acidosis (HP:0003128)2.22899166
53Respiratory difficulties (HP:0002880)2.19242631
54Abnormality of renal resorption (HP:0011038)2.16567149
55Hyperphosphaturia (HP:0003109)2.11784384
56Leukodystrophy (HP:0002415)2.10316056
57Tubular atrophy (HP:0000092)2.10126574
58Increased IgM level (HP:0003496)2.09523255
59Abnormal biliary tract physiology (HP:0012439)2.07913175
60Bile duct proliferation (HP:0001408)2.07913175
61Abnormality of macular pigmentation (HP:0008002)2.07370327
62Acute hepatic failure (HP:0006554)2.07359388
63Exercise intolerance (HP:0003546)2.06697256
64Mesangial abnormality (HP:0001966)2.06572444
65Abnormality of vitamin metabolism (HP:0100508)2.05964847
66Limb hypertonia (HP:0002509)2.05558634
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05191635
68Dicarboxylic aciduria (HP:0003215)2.05191635
69Microvesicular hepatic steatosis (HP:0001414)2.03764609
70Aplasia/hypoplasia of the uterus (HP:0008684)2.03348566
71Abolished electroretinogram (ERG) (HP:0000550)2.00143836
72Abnormality of the renal medulla (HP:0100957)2.00043921
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99077036
74T lymphocytopenia (HP:0005403)1.98773378
75Cheilitis (HP:0100825)1.97981679
76Colon cancer (HP:0003003)1.97779738
77Abnormality of T cells (HP:0002843)1.95591406
78Muscular hypotonia of the trunk (HP:0008936)1.93731497
79Palpitations (HP:0001962)1.93270335
80Increased intramyocellular lipid droplets (HP:0012240)1.92870364
81Pancytopenia (HP:0001876)1.91879403
82IgA deficiency (HP:0002720)1.91703488
83Recurrent cutaneous fungal infections (HP:0011370)1.90291072
84Chronic mucocutaneous candidiasis (HP:0002728)1.90291072
85Abnormal rod and cone electroretinograms (HP:0008323)1.90289014
86Muscle fibrillation (HP:0010546)1.90264797
87Proximal tubulopathy (HP:0000114)1.89943492
88Gonadotropin excess (HP:0000837)1.89187007
89Type II lissencephaly (HP:0007260)1.86811890
90Abnormality of the fovea (HP:0000493)1.86377297
91Paralysis (HP:0003470)1.83878296
92Abnormality of T cell physiology (HP:0011840)1.83281980
93Abnormal pupillary function (HP:0007686)1.81861303
94X-linked dominant inheritance (HP:0001423)1.81340227
95Homocystinuria (HP:0002156)1.81035536
96Abnormality of homocysteine metabolism (HP:0010919)1.81035536
97Abnormality of T cell number (HP:0011839)1.80837746
98Abnormal drinking behavior (HP:0030082)1.78564457
99Polydipsia (HP:0001959)1.78564457
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77990043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.63187165
2MST44.55796153
3EIF2AK33.21651197
4TXK3.11091746
5VRK23.03496726
6NUAK12.76400541
7ADRBK22.72101923
8MAP3K122.69530630
9FRK2.53153531
10TRIM282.42631776
11NME12.26149527
12PBK2.13205416
13WNK41.95927358
14EIF2AK11.86262605
15GRK11.86068865
16MAP4K21.83927393
17VRK11.71028068
18ZAK1.64635779
19BMPR1B1.63258886
20NEK11.54007166
21MAP3K91.52262642
22PLK31.51601422
23SIK31.47129023
24TNIK1.46026569
25TESK11.41032481
26PINK11.39310763
27STK391.36906510
28TEC1.31484744
29TLK11.30104383
30MYLK1.26545966
31MAP2K61.25721951
32NLK1.21295443
33OXSR11.19076266
34MAPKAPK31.18835731
35SRPK11.17546502
36ACVR1B1.14836825
37STK31.09628550
38ITK1.09449383
39CSNK1G11.09054770
40DAPK11.05914128
41WNK31.05634669
42STK241.01431498
43TNK20.98446561
44PHKG20.95402091
45PHKG10.95402091
46CLK10.94360365
47CSNK1G30.88995391
48STK160.84441704
49STK40.84055514
50EIF2AK20.84000095
51TGFBR10.82486825
52MUSK0.80515195
53IKBKB0.77714378
54TAF10.76402966
55PLK20.76063740
56PAK30.75069942
57PASK0.75049842
58DAPK20.71559567
59MAP3K40.66649050
60STK38L0.64143884
61TAOK30.63897339
62ERBB30.63265032
63CASK0.63165274
64CSNK1A1L0.61850644
65CSNK1G20.59983830
66TRPM70.58668627
67ALK0.57650208
68PIK3CG0.57441324
69PRKCE0.56309404
70ADRBK10.54422026
71TIE10.53611104
72LATS10.53025550
73BUB10.50157828
74WNK10.49288895
75INSRR0.44555897
76MKNK20.42362250
77PRKCG0.41329281
78CAMK2A0.39337918
79ILK0.38005414
80CAMK2D0.36324912
81PRKG10.36038425
82PDK20.35940359
83MAP4K10.35847319
84FGFR10.33995110
85BCR0.29895042
86KDR0.27332997
87PAK40.26805839
88CSNK1A10.26111631
89PRKCQ0.25416507
90IKBKE0.24829701
91CSNK2A20.24666857
92PLK40.24397065
93PRKCA0.23108798
94RPS6KA50.22665289
95DAPK30.20955237
96GSK3A0.20804520
97FLT30.19847254
98PRKCB0.19700725
99PRKACA0.19618312
100LCK0.19373283

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.12470411
2Protein export_Homo sapiens_hsa030604.46395831
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78452765
4RNA polymerase_Homo sapiens_hsa030202.72537501
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65284925
6Oxidative phosphorylation_Homo sapiens_hsa001902.58055359
7Asthma_Homo sapiens_hsa053102.56840018
8Allograft rejection_Homo sapiens_hsa053302.51779378
9Type I diabetes mellitus_Homo sapiens_hsa049402.32770904
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20099439
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06668440
12Autoimmune thyroid disease_Homo sapiens_hsa053202.02563609
13RNA degradation_Homo sapiens_hsa030181.97300854
14Sulfur metabolism_Homo sapiens_hsa009201.96853346
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96374599
16Parkinsons disease_Homo sapiens_hsa050121.92231771
17Propanoate metabolism_Homo sapiens_hsa006401.91019996
18Basal transcription factors_Homo sapiens_hsa030221.76822600
19One carbon pool by folate_Homo sapiens_hsa006701.64866502
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.63287315
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60566574
22Butanoate metabolism_Homo sapiens_hsa006501.59827799
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44604116
24Vitamin B6 metabolism_Homo sapiens_hsa007501.40970018
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.40773779
26Regulation of autophagy_Homo sapiens_hsa041401.39788201
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38329842
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37285752
29RNA transport_Homo sapiens_hsa030131.28895343
30Hematopoietic cell lineage_Homo sapiens_hsa046401.28564743
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27993921
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24210139
33Alzheimers disease_Homo sapiens_hsa050101.24115285
34Huntingtons disease_Homo sapiens_hsa050161.23664766
35Caffeine metabolism_Homo sapiens_hsa002321.19948942
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19377372
37Peroxisome_Homo sapiens_hsa041461.19077077
38Purine metabolism_Homo sapiens_hsa002301.16594829
39Primary immunodeficiency_Homo sapiens_hsa053401.12547335
40Phototransduction_Homo sapiens_hsa047441.12382953
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10373001
42Linoleic acid metabolism_Homo sapiens_hsa005911.09402189
43Measles_Homo sapiens_hsa051621.05349378
44T cell receptor signaling pathway_Homo sapiens_hsa046601.04193331
45Mismatch repair_Homo sapiens_hsa034301.04189392
46Pyrimidine metabolism_Homo sapiens_hsa002401.01111970
47Collecting duct acid secretion_Homo sapiens_hsa049660.89847406
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82066250
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.81489326
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81382286
51Fanconi anemia pathway_Homo sapiens_hsa034600.81134521
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80072474
53Nucleotide excision repair_Homo sapiens_hsa034200.77149862
54Non-homologous end-joining_Homo sapiens_hsa034500.72626828
55Homologous recombination_Homo sapiens_hsa034400.71899184
56Tryptophan metabolism_Homo sapiens_hsa003800.69805468
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69575246
58Ether lipid metabolism_Homo sapiens_hsa005650.68306502
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.67242864
60Nitrogen metabolism_Homo sapiens_hsa009100.66493789
61Graft-versus-host disease_Homo sapiens_hsa053320.65751288
62Selenocompound metabolism_Homo sapiens_hsa004500.64886678
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64304587
64Cardiac muscle contraction_Homo sapiens_hsa042600.63000066
65Steroid biosynthesis_Homo sapiens_hsa001000.62359273
66Rheumatoid arthritis_Homo sapiens_hsa053230.61037593
67Folate biosynthesis_Homo sapiens_hsa007900.60389820
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.58958245
69Antigen processing and presentation_Homo sapiens_hsa046120.58780755
70Metabolic pathways_Homo sapiens_hsa011000.55508391
71Ribosome_Homo sapiens_hsa030100.53541422
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53369837
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.51255330
74Spliceosome_Homo sapiens_hsa030400.48705698
75Nicotine addiction_Homo sapiens_hsa050330.43468413
76Retinol metabolism_Homo sapiens_hsa008300.43074770
77Pyruvate metabolism_Homo sapiens_hsa006200.42297780
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39709276
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39282415
80beta-Alanine metabolism_Homo sapiens_hsa004100.37111044
81Circadian rhythm_Homo sapiens_hsa047100.35225225
82Insulin secretion_Homo sapiens_hsa049110.34645599
83Arachidonic acid metabolism_Homo sapiens_hsa005900.34102637
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32449046
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30840710
86ABC transporters_Homo sapiens_hsa020100.30490189
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30060860
88Fatty acid degradation_Homo sapiens_hsa000710.30057030
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30032856
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.29859745
91Epstein-Barr virus infection_Homo sapiens_hsa051690.29288007
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27851057
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27831528
94Fat digestion and absorption_Homo sapiens_hsa049750.23692359
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21853235
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20175214
97Morphine addiction_Homo sapiens_hsa050320.18898289
98Malaria_Homo sapiens_hsa051440.18362029
99N-Glycan biosynthesis_Homo sapiens_hsa005100.18206344
100Chemical carcinogenesis_Homo sapiens_hsa052040.18151424

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