CDC42P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma-mediated signaling pathway (GO:0060333)5.03704481
2one-carbon compound transport (GO:0019755)4.46925272
3negative regulation of heart rate (GO:0010459)4.45628510
4cullin deneddylation (GO:0010388)4.40577250
5cytokine biosynthetic process (GO:0042089)4.38630485
6regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.34460128
7cellular response to interferon-gamma (GO:0071346)4.07075170
8regulation of triglyceride catabolic process (GO:0010896)4.01261307
9immunoglobulin mediated immune response (GO:0016064)3.91090428
10neutrophil activation involved in immune response (GO:0002283)3.89010529
11lymphocyte costimulation (GO:0031294)3.87043616
12positive thymic T cell selection (GO:0045059)3.78178327
13regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.77453823
14negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.74634318
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.74044232
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69098069
17ATP synthesis coupled proton transport (GO:0015986)3.69098069
18mast cell activation (GO:0045576)3.68564557
19cytokine metabolic process (GO:0042107)3.68531226
20T cell costimulation (GO:0031295)3.64086125
21protein deneddylation (GO:0000338)3.61182467
22positive T cell selection (GO:0043368)3.60818833
23regulation of isotype switching to IgG isotypes (GO:0048302)3.60762898
24negative regulation of acute inflammatory response (GO:0002674)3.52464270
25response to interferon-gamma (GO:0034341)3.51885623
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39040322
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39033066
28aggressive behavior (GO:0002118)3.31816579
29mast cell degranulation (GO:0043303)3.29519764
30mast cell activation involved in immune response (GO:0002279)3.29519764
31regulation of MHC class II biosynthetic process (GO:0045346)3.29064842
32transepithelial transport (GO:0070633)3.28530065
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.28493777
34positive regulation of smooth muscle cell migration (GO:0014911)3.28318473
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26182948
36purinergic nucleotide receptor signaling pathway (GO:0035590)3.25270509
37drinking behavior (GO:0042756)3.21168537
38regulation of glucokinase activity (GO:0033131)3.15465984
39regulation of hexokinase activity (GO:1903299)3.15465984
40B cell mediated immunity (GO:0019724)3.15147096
41mature B cell differentiation involved in immune response (GO:0002313)3.12975472
42aldehyde catabolic process (GO:0046185)3.09546576
43sleep (GO:0030431)3.09235908
44lymphoid progenitor cell differentiation (GO:0002320)3.09172098
45positive regulation of granulocyte differentiation (GO:0030854)3.06562938
46positive regulation of uterine smooth muscle contraction (GO:0070474)3.04680297
47positive regulation of interleukin-1 beta secretion (GO:0050718)3.03186333
48negative regulation of lipid storage (GO:0010888)3.02155117
49regulation of alpha-beta T cell proliferation (GO:0046640)2.96354459
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94707330
51negative regulation of T-helper cell differentiation (GO:0045623)2.94707330
52mitochondrial calcium ion transport (GO:0006851)2.91739321
53positive regulation of triglyceride lipase activity (GO:0061365)2.88108213
54positive regulation of lipoprotein lipase activity (GO:0051006)2.88108213
55positive regulation of monocyte chemotaxis (GO:0090026)2.86019712
56positive regulation of interleukin-1 secretion (GO:0050716)2.85339754
57negative regulation of alpha-beta T cell activation (GO:0046636)2.85056691
58ribosomal large subunit biogenesis (GO:0042273)2.84791799
59regulation of interleukin-1 beta secretion (GO:0050706)2.84281376
60positive regulation of antigen processing and presentation (GO:0002579)2.83786463
61histone H3-K4 trimethylation (GO:0080182)2.82822919
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.82693873
63negative regulation of macrophage differentiation (GO:0045650)2.82549301
64transcription elongation from RNA polymerase III promoter (GO:0006385)2.80073913
65termination of RNA polymerase III transcription (GO:0006386)2.80073913
66T cell receptor signaling pathway (GO:0050852)2.77744391
67Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75739892
68anterograde synaptic vesicle transport (GO:0048490)2.74459340
69regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.73942426
70electron transport chain (GO:0022900)2.73353877
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72546237
72respiratory electron transport chain (GO:0022904)2.72310195
73relaxation of smooth muscle (GO:0044557)2.71965748
74positive regulation of interleukin-1 beta production (GO:0032731)2.71962474
75production of molecular mediator of immune response (GO:0002440)2.71799947
76chaperone-mediated protein transport (GO:0072321)2.71740195
77antigen receptor-mediated signaling pathway (GO:0050851)2.70665154
78regulation of antigen processing and presentation (GO:0002577)2.69780149
79mature B cell differentiation (GO:0002335)2.69598535
80CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.68870376
81T-helper cell differentiation (GO:0042093)2.68870376
82regulation of mast cell activation (GO:0033003)2.68693472
83defense response to protozoan (GO:0042832)2.68251915
84respiratory chain complex IV assembly (GO:0008535)2.66076774
85regulation of urine volume (GO:0035809)2.63165285
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62891029
87positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.62612367
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61547587
89phagocytosis, engulfment (GO:0006911)2.61045727
90regulation of glomerular filtration (GO:0003093)2.60990131
91positive regulation of mast cell activation (GO:0033005)2.60657142
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.58332694
93regulation of chronic inflammatory response (GO:0002676)2.57940943
94negative regulation of T cell differentiation in thymus (GO:0033085)2.55882812
95positive regulation of T cell proliferation (GO:0042102)2.55702561
96regulation of interleukin-1 secretion (GO:0050704)2.55467733
97positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.55204447
98positive regulation of interleukin-10 production (GO:0032733)2.55129554
99auditory receptor cell stereocilium organization (GO:0060088)2.54467263
100regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.54235092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.08886022
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.90477620
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.40212461
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.33845006
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13925952
6ZNF274_21170338_ChIP-Seq_K562_Hela2.99185691
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.98529976
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.88524378
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73257134
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71742861
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.59422003
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57667910
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13683051
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05116584
15FUS_26573619_Chip-Seq_HEK293_Human1.94328347
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94072374
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90031895
18VDR_23849224_ChIP-Seq_CD4+_Human1.84697645
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83346745
20MYB_26560356_Chip-Seq_TH2_Human1.76393558
21GATA3_26560356_Chip-Seq_TH2_Human1.71261741
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.70597951
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68627864
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65465420
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62542303
26VDR_22108803_ChIP-Seq_LS180_Human1.56795293
27FOXP3_21729870_ChIP-Seq_TREG_Human1.56582066
28CIITA_25753668_ChIP-Seq_RAJI_Human1.56421705
29SPI1_23547873_ChIP-Seq_NB4_Human1.53901813
30TAF15_26573619_Chip-Seq_HEK293_Human1.50324267
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49863879
32IRF1_19129219_ChIP-ChIP_H3396_Human1.49749535
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.47721624
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46828520
35P300_19829295_ChIP-Seq_ESCs_Human1.46441059
36ELK1_19687146_ChIP-ChIP_HELA_Human1.45545208
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44736292
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39147804
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.39085161
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36669320
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36272773
42NANOG_19829295_ChIP-Seq_ESCs_Human1.34311989
43SOX2_19829295_ChIP-Seq_ESCs_Human1.34311989
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34194964
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33850892
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32848209
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31035553
48EWS_26573619_Chip-Seq_HEK293_Human1.30574229
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27794763
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25661216
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.24768014
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24517798
53P300_27268052_Chip-Seq_Bcells_Human1.22528754
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21847077
55ERG_20517297_ChIP-Seq_VCAP_Human1.19710251
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18207949
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.17915016
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15052643
59MYC_18940864_ChIP-ChIP_HL60_Human1.13838814
60GATA3_26560356_Chip-Seq_TH1_Human1.12669112
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12528897
62TP53_22573176_ChIP-Seq_HFKS_Human1.11952719
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11322084
64TAF2_19829295_ChIP-Seq_ESCs_Human1.10986355
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10662524
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.10662524
67VDR_24787735_ChIP-Seq_THP-1_Human1.08798202
68AR_21572438_ChIP-Seq_LNCaP_Human1.08749992
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.07926045
70EGR1_19032775_ChIP-ChIP_M12_Human1.07855429
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05743192
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05521078
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04038077
74AR_20517297_ChIP-Seq_VCAP_Human1.03614199
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.02250519
76RUNX_20019798_ChIP-Seq_JUKART_Human1.00230224
77GATA3_27048872_Chip-Seq_THYMUS_Human0.99300417
78ER_23166858_ChIP-Seq_MCF-7_Human0.97587211
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97336532
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96901305
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96826754
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96567171
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95940140
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95826137
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95443793
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94627807
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93844478
88WDR5_24793694_ChIP-Seq_LNCAP_Human0.93350125
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92128320
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90649891
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90099958
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89968556
93SALL4_22934838_ChIP-ChIP_CD34+_Human0.88740164
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88686864
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86511347
96CBP_21632823_ChIP-Seq_H3396_Human0.84868641
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84197817
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.83587727
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.82556248
100MYC_19829295_ChIP-Seq_ESCs_Human0.82474197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.42232819
2MP0009785_altered_susceptibility_to3.30698661
3MP0005671_abnormal_response_to3.29853512
4MP0008875_abnormal_xenobiotic_pharmacok3.12081951
5MP0003724_increased_susceptibility_to2.94361042
6MP0002736_abnormal_nociception_after2.84877197
7MP0002166_altered_tumor_susceptibility2.81857079
8MP0008872_abnormal_physiological_respon2.68566073
9MP0003880_abnormal_central_pattern2.63928598
10MP0001873_stomach_inflammation2.60476571
11MP0001968_abnormal_touch/_nociception2.54040629
12MP0000516_abnormal_urinary_system2.53901659
13MP0005367_renal/urinary_system_phenotyp2.53901659
14MP0003806_abnormal_nucleotide_metabolis2.53150764
15MP0005000_abnormal_immune_tolerance2.50969242
16MP0003436_decreased_susceptibility_to2.48022524
17MP0001800_abnormal_humoral_immune2.46378304
18MP0003866_abnormal_defecation2.30570480
19MP0002006_tumorigenesis2.25948250
20MP0002102_abnormal_ear_morphology2.16940090
21MP0004147_increased_porphyrin_level2.15588236
22MP0002735_abnormal_chemical_nociception2.10603194
23MP0001986_abnormal_taste_sensitivity2.07647951
24MP0006082_CNS_inflammation1.99789070
25MP0010155_abnormal_intestine_physiology1.96121198
26MP0002148_abnormal_hypersensitivity_rea1.94181603
27MP0005025_abnormal_response_to1.93822638
28MP0002723_abnormal_immune_serum1.81795097
29MP0009764_decreased_sensitivity_to1.79288521
30MP0009333_abnormal_splenocyte_physiolog1.74250136
31MP0006036_abnormal_mitochondrial_physio1.73536406
32MP0002452_abnormal_antigen_presenting1.69524533
33MP0001790_abnormal_immune_system1.59982799
34MP0005387_immune_system_phenotype1.59982799
35MP0002420_abnormal_adaptive_immunity1.54148506
36MP0002419_abnormal_innate_immunity1.52404230
37MP0001819_abnormal_immune_cell1.50382878
38MP0002009_preneoplasia1.42871983
39MP0008469_abnormal_protein_level1.41171350
40MP0003303_peritoneal_inflammation1.40696739
41MP0005360_urolithiasis1.39653709
42MP0003195_calcinosis1.31397990
43MP0001663_abnormal_digestive_system1.27088536
44MP0000858_altered_metastatic_potential1.25920226
45MP0009379_abnormal_foot_pigmentation1.24154832
46MP0003567_abnormal_fetal_cardiomyocyte1.22364412
47MP0001845_abnormal_inflammatory_respons1.22251956
48MP0000685_abnormal_immune_system1.21435996
49MP0010386_abnormal_urinary_bladder1.11427623
50MP0000716_abnormal_immune_system1.11391571
51MP0002398_abnormal_bone_marrow1.10051877
52MP0008058_abnormal_DNA_repair1.08470576
53MP0005166_decreased_susceptibility_to1.05566818
54MP0001664_abnormal_digestion1.05339413
55MP0005464_abnormal_platelet_physiology1.04666010
56MP0001348_abnormal_lacrimal_gland1.03728527
57MP0006072_abnormal_retinal_apoptosis1.00762660
58MP0003075_altered_response_to1.00738633
59MP0005365_abnormal_bile_salt1.00066938
60MP0005075_abnormal_melanosome_morpholog0.99746282
61MP0001533_abnormal_skeleton_physiology0.98334168
62MP0000465_gastrointestinal_hemorrhage0.96919405
63MP0001853_heart_inflammation0.96857795
64MP0001970_abnormal_pain_threshold0.96716086
65MP0006276_abnormal_autonomic_nervous0.95616200
66MP0001545_abnormal_hematopoietic_system0.90785443
67MP0005397_hematopoietic_system_phenotyp0.90785443
68MP0002272_abnormal_nervous_system0.86242956
69MP0005310_abnormal_salivary_gland0.84318538
70MP0002693_abnormal_pancreas_physiology0.83593514
71MP0002132_abnormal_respiratory_system0.83092960
72MP0001542_abnormal_bone_strength0.82372894
73MP0002429_abnormal_blood_cell0.82179894
74MP0003786_premature_aging0.78006506
75MP0008995_early_reproductive_senescence0.77565325
76MP0003787_abnormal_imprinting0.77093302
77MP0003646_muscle_fatigue0.76635358
78MP0005085_abnormal_gallbladder_physiolo0.76468247
79MP0000689_abnormal_spleen_morphology0.75796086
80MP0009046_muscle_twitch0.75425225
81MP0002405_respiratory_system_inflammati0.74506061
82MP0001879_abnormal_lymphatic_vessel0.73148715
83MP0005381_digestive/alimentary_phenotyp0.72782926
84MP0005535_abnormal_body_temperature0.72452941
85MP0003763_abnormal_thymus_physiology0.70006358
86MP0001905_abnormal_dopamine_level0.69676131
87MP0001756_abnormal_urination0.67493163
88MP0005165_increased_susceptibility_to0.67371818
89MP0001881_abnormal_mammary_gland0.66804922
90MP0004142_abnormal_muscle_tone0.65257505
91MP0003448_altered_tumor_morphology0.64158423
92MP0006035_abnormal_mitochondrial_morpho0.62512501
93MP0005551_abnormal_eye_electrophysiolog0.61590857
94MP0003300_gastrointestinal_ulcer0.61563000
95MP0002876_abnormal_thyroid_physiology0.61518036
96MP0002019_abnormal_tumor_incidence0.61147519
97MP0009643_abnormal_urine_homeostasis0.60234700
98MP0000013_abnormal_adipose_tissue0.59191589
99MP0008873_increased_physiological_sensi0.58205215
100MP0000538_abnormal_urinary_bladder0.58094600

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.01663971
2Hypothermia (HP:0002045)4.21704169
3Myositis (HP:0100614)4.16870585
4Orchitis (HP:0100796)4.04382364
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.94874401
6Hepatic necrosis (HP:0002605)3.88856667
7Retrobulbar optic neuritis (HP:0100654)3.85370383
8Optic neuritis (HP:0100653)3.85370383
9Focal motor seizures (HP:0011153)3.63248073
10Elevated erythrocyte sedimentation rate (HP:0003565)3.56482563
11Vaginal fistula (HP:0004320)3.55293947
12Rectovaginal fistula (HP:0000143)3.52357293
13Rectal fistula (HP:0100590)3.52357293
14Mitochondrial inheritance (HP:0001427)3.49414469
15Acute necrotizing encephalopathy (HP:0006965)3.43436109
16Abnormal mitochondria in muscle tissue (HP:0008316)3.25476957
17Type I transferrin isoform profile (HP:0003642)3.25090673
18Aplastic anemia (HP:0001915)3.23133931
19Short tibia (HP:0005736)3.19005673
20Increased CSF lactate (HP:0002490)3.10517766
21Hypoproteinemia (HP:0003075)3.07479808
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06918064
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06918064
24Progressive macrocephaly (HP:0004481)3.06663039
25Aplasia/Hypoplasia of the tibia (HP:0005772)3.02957453
26Congenital, generalized hypertrichosis (HP:0004540)3.02279171
27Intestinal fistula (HP:0100819)2.99145919
28Hyperventilation (HP:0002883)2.98870659
29Recurrent abscess formation (HP:0002722)2.94238836
30Increased intramyocellular lipid droplets (HP:0012240)2.89459587
31Abnormality of the prostate (HP:0008775)2.78839296
32Generalized aminoaciduria (HP:0002909)2.75966127
33Submucous cleft hard palate (HP:0000176)2.69214645
34Alveolar cell carcinoma (HP:0006519)2.67509954
35Keratoconjunctivitis sicca (HP:0001097)2.65897290
36Panhypogammaglobulinemia (HP:0003139)2.63345139
37Hypoalbuminemia (HP:0003073)2.63321630
38Abnormal albumin level (HP:0012116)2.63321630
39Acute encephalopathy (HP:0006846)2.57784489
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56373539
41Recurrent bacterial skin infections (HP:0005406)2.50179832
42Hemoptysis (HP:0002105)2.50089185
43Keratoconjunctivitis (HP:0001096)2.49170479
44Pulmonary infiltrates (HP:0002113)2.46593550
45Increased muscle lipid content (HP:0009058)2.46195448
46Exertional dyspnea (HP:0002875)2.42704009
47Gangrene (HP:0100758)2.41662652
48Chronic otitis media (HP:0000389)2.37115489
49Encephalitis (HP:0002383)2.34361753
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33929062
51Midline defect of the nose (HP:0004122)2.30989804
52Gastrointestinal infarctions (HP:0005244)2.28260523
533-Methylglutaconic aciduria (HP:0003535)2.28238947
54Abnormal protein glycosylation (HP:0012346)2.28033273
55Abnormal glycosylation (HP:0012345)2.28033273
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28033273
57Abnormal protein N-linked glycosylation (HP:0012347)2.28033273
58Congenital ichthyosiform erythroderma (HP:0007431)2.27685814
59Acute lymphatic leukemia (HP:0006721)2.26138417
60Polyneuropathy (HP:0001271)2.25801609
61Febrile seizures (HP:0002373)2.19819615
62Increased serum lactate (HP:0002151)2.16179146
63Neoplasm of the tracheobronchial system (HP:0100552)2.15947499
64Broad-based gait (HP:0002136)2.15423050
65Recurrent skin infections (HP:0001581)2.15248301
66Abnormality of midbrain morphology (HP:0002418)2.14079691
67Molar tooth sign on MRI (HP:0002419)2.14079691
68Cerebral edema (HP:0002181)2.08260578
69Optic disc pallor (HP:0000543)2.07878927
70Flat capital femoral epiphysis (HP:0003370)2.06864869
71Upper motor neuron abnormality (HP:0002127)2.06121745
72Stomatitis (HP:0010280)2.05180022
73Chest pain (HP:0100749)2.05138810
74Global brain atrophy (HP:0002283)2.04374375
75Increased hepatocellular lipid droplets (HP:0006565)2.03463857
76Chronic mucocutaneous candidiasis (HP:0002728)2.03457161
77Recurrent cutaneous fungal infections (HP:0011370)2.03457161
78Progressive microcephaly (HP:0000253)2.00854133
79Short nail (HP:0001799)1.99046471
80Vasculitis (HP:0002633)1.98914566
81Obstructive lung disease (HP:0006536)1.98591812
82Chronic obstructive pulmonary disease (HP:0006510)1.98591812
83CNS demyelination (HP:0007305)1.97216491
84Meningitis (HP:0001287)1.94274066
85Reduced antithrombin III activity (HP:0001976)1.90639159
86Urticaria (HP:0001025)1.90638877
87Glucose intolerance (HP:0000833)1.90344911
88Abnormality of the pleura (HP:0002103)1.89978362
89Lactic acidosis (HP:0003128)1.88823988
90Stomach cancer (HP:0012126)1.88436642
91Lipid accumulation in hepatocytes (HP:0006561)1.84936898
92Paresthesia (HP:0003401)1.83969726
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83674082
94Agammaglobulinemia (HP:0004432)1.83337364
95Joint swelling (HP:0001386)1.83005930
96Ectropion (HP:0000656)1.82609975
97Exercise intolerance (HP:0003546)1.81802713
98Bulbous nose (HP:0000414)1.80423822
99Abnormality of the peritoneum (HP:0002585)1.79411604
100Hypoplasia of the thymus (HP:0000778)1.78993994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.12651187
2BMPR24.20499623
3CDK193.95327520
4TAOK33.25455825
5NUAK12.82635656
6MST42.78458279
7MYLK2.55991037
8CASK2.41040134
9FES2.22725086
10TEC2.01552510
11TLK12.00537446
12MAP2K61.92296761
13MAP3K141.89146738
14INSRR1.87357366
15ILK1.87269267
16NTRK31.80354734
17TXK1.80127194
18CSF1R1.79497579
19PBK1.74718199
20BCKDK1.65612326
21ITK1.63496904
22BTK1.60426574
23FLT31.57235154
24KIT1.51918192
25IKBKB1.45771293
26MAP4K21.42387282
27IKBKE1.33702064
28GRK61.31723955
29TBK11.27093602
30OXSR11.26050203
31DAPK31.25872728
32LATS11.24723012
33VRK21.22859172
34DAPK21.20546264
35DAPK11.19226009
36TYK21.18246422
37MAP4K11.15957293
38JAK31.12509778
39CDK81.09085863
40DYRK21.08836879
41SYK1.04022693
42JAK11.00395367
43HCK1.00296973
44ERBB30.99443621
45NME20.92789028
46LYN0.87901209
47LCK0.87068998
48CSNK1G20.86783204
49TSSK60.84300484
50PAK40.79104497
51IGF1R0.75706850
52CCNB10.71942369
53WNK30.68631174
54ADRBK20.66154884
55ABL10.64307873
56BLK0.63593632
57TRPM70.63115236
58CAMKK20.62135854
59MARK30.62010668
60MAP2K70.59834619
61PTK2B0.56630471
62TGFBR20.54903566
63CHUK0.54587237
64MAPK130.54296421
65CAMK2D0.52330751
66NEK10.51436129
67RPS6KB10.49827676
68ERN10.49744656
69TIE10.49424527
70STK110.48583426
71PASK0.48559654
72GRK10.47559961
73EGFR0.47194928
74PIK3CG0.46048607
75KDR0.44985957
76FRK0.43997017
77MARK10.43552881
78EIF2AK10.43502021
79JAK20.42118804
80PRKG20.41255162
81TAF10.40706384
82CAMK2G0.40143261
83MATK0.40003870
84PINK10.39032010
85RPS6KA50.38521935
86GRK70.38082882
87PRKG10.35281811
88PDK10.34802653
89ROCK10.34311578
90CSNK1G30.33601248
91PAK10.33261416
92VRK10.32805226
93OBSCN0.32750982
94CAMK2A0.31479837
95PKN10.30446467
96FYN0.29560886
97EPHA30.28370996
98GRK50.27890489
99HIPK20.26803523
100EIF2AK20.24867925

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053106.48973457
2Allograft rejection_Homo sapiens_hsa053305.34210499
3Autoimmune thyroid disease_Homo sapiens_hsa053205.06724379
4Graft-versus-host disease_Homo sapiens_hsa053324.27347008
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.15764838
6Type I diabetes mellitus_Homo sapiens_hsa049403.80479953
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.46929051
8Staphylococcus aureus infection_Homo sapiens_hsa051502.64329127
9Leishmaniasis_Homo sapiens_hsa051402.48146432
10Antigen processing and presentation_Homo sapiens_hsa046122.42837268
11Viral myocarditis_Homo sapiens_hsa054162.37137953
12Rheumatoid arthritis_Homo sapiens_hsa053231.98136876
13Oxidative phosphorylation_Homo sapiens_hsa001901.95176868
14Proteasome_Homo sapiens_hsa030501.82545435
15Protein export_Homo sapiens_hsa030601.62599834
16Ribosome_Homo sapiens_hsa030101.62108200
17Parkinsons disease_Homo sapiens_hsa050121.59614736
18RNA polymerase_Homo sapiens_hsa030201.56967847
19Toxoplasmosis_Homo sapiens_hsa051451.36564665
20Hematopoietic cell lineage_Homo sapiens_hsa046401.34719274
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28109275
22One carbon pool by folate_Homo sapiens_hsa006701.19984801
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10895085
24Influenza A_Homo sapiens_hsa051641.06671081
25Alzheimers disease_Homo sapiens_hsa050101.03160093
26Tuberculosis_Homo sapiens_hsa051521.03074445
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01012912
28Systemic lupus erythematosus_Homo sapiens_hsa053220.98542614
29Jak-STAT signaling pathway_Homo sapiens_hsa046300.96454649
30Herpes simplex infection_Homo sapiens_hsa051680.94124140
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90155488
32Cardiac muscle contraction_Homo sapiens_hsa042600.89054507
33Nitrogen metabolism_Homo sapiens_hsa009100.87485907
34Huntingtons disease_Homo sapiens_hsa050160.79879200
35Phagosome_Homo sapiens_hsa041450.79736404
36Phototransduction_Homo sapiens_hsa047440.73886598
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70432634
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65386958
39Epstein-Barr virus infection_Homo sapiens_hsa051690.63004929
40Fatty acid biosynthesis_Homo sapiens_hsa000610.59993566
41Primary immunodeficiency_Homo sapiens_hsa053400.59690417
42Collecting duct acid secretion_Homo sapiens_hsa049660.58297049
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55834152
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54031036
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52684783
46Tryptophan metabolism_Homo sapiens_hsa003800.50187461
47Legionellosis_Homo sapiens_hsa051340.48713364
48Regulation of autophagy_Homo sapiens_hsa041400.45985676
49Nicotine addiction_Homo sapiens_hsa050330.45829752
50Salivary secretion_Homo sapiens_hsa049700.43859800
51Platelet activation_Homo sapiens_hsa046110.43523212
52Osteoclast differentiation_Homo sapiens_hsa043800.43486626
53T cell receptor signaling pathway_Homo sapiens_hsa046600.43432508
54Measles_Homo sapiens_hsa051620.42911343
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41649757
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35188203
57Pertussis_Homo sapiens_hsa051330.34683621
58Renin secretion_Homo sapiens_hsa049240.33508242
59Olfactory transduction_Homo sapiens_hsa047400.33010459
60Basal transcription factors_Homo sapiens_hsa030220.32639825
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32435947
62Salmonella infection_Homo sapiens_hsa051320.32385724
63Butanoate metabolism_Homo sapiens_hsa006500.29861988
64African trypanosomiasis_Homo sapiens_hsa051430.29456762
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.28888154
66Circadian entrainment_Homo sapiens_hsa047130.28467693
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.26305390
68Propanoate metabolism_Homo sapiens_hsa006400.24493324
69Pyrimidine metabolism_Homo sapiens_hsa002400.22879696
70Sulfur relay system_Homo sapiens_hsa041220.22048236
71Taste transduction_Homo sapiens_hsa047420.21580282
72Non-homologous end-joining_Homo sapiens_hsa034500.21384606
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20550786
74Chemical carcinogenesis_Homo sapiens_hsa052040.19934541
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18989917
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18145282
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17409615
78Arachidonic acid metabolism_Homo sapiens_hsa005900.16977481
79RNA degradation_Homo sapiens_hsa030180.16239512
80Ether lipid metabolism_Homo sapiens_hsa005650.15440436
81Long-term depression_Homo sapiens_hsa047300.15419532
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.14611854
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.13589992
84Linoleic acid metabolism_Homo sapiens_hsa005910.13002841
85Retinol metabolism_Homo sapiens_hsa008300.12773932
86Pyruvate metabolism_Homo sapiens_hsa006200.10906328
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10349060
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09281218
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08312088
90HTLV-I infection_Homo sapiens_hsa051660.08281714
91Fanconi anemia pathway_Homo sapiens_hsa034600.08250472
92Metabolic pathways_Homo sapiens_hsa011000.07595762
93Calcium signaling pathway_Homo sapiens_hsa040200.05899615
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05402442
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05109330
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04580942
97Peroxisome_Homo sapiens_hsa041460.04150813
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03678968
99Steroid biosynthesis_Homo sapiens_hsa001000.03017354
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02781885

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