CDC42P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)6.46562498
2T-helper cell differentiation (GO:0042093)6.46562498
3alpha-beta T cell differentiation (GO:0046632)6.26924977
4interferon-gamma production (GO:0032609)5.96491712
5chaperone mediated protein folding requiring cofactor (GO:0051085)5.94145043
6protein refolding (GO:0042026)5.82899782
7regulation of somitogenesis (GO:0014807)5.78396069
8T cell differentiation involved in immune response (GO:0002292)5.67980333
9alpha-beta T cell differentiation involved in immune response (GO:0002293)5.67980333
10alpha-beta T cell activation involved in immune response (GO:0002287)5.67980333
11regulation of B cell receptor signaling pathway (GO:0050855)5.48836483
12maturation of 5.8S rRNA (GO:0000460)5.35571293
13alpha-beta T cell activation (GO:0046631)5.35175346
14histone H3-K4 trimethylation (GO:0080182)4.82575538
15interleukin-6-mediated signaling pathway (GO:0070102)4.82141588
16regulation of interleukin-12 biosynthetic process (GO:0045075)4.67215639
17regulation of isotype switching to IgG isotypes (GO:0048302)4.56920708
18CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.45310443
19regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.39633401
20negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.30986823
21pseudouridine synthesis (GO:0001522)4.26425254
22positive regulation of histone H3-K4 methylation (GO:0051571)4.26043849
23negative regulation of inclusion body assembly (GO:0090084)4.20391099
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16199311
25CD4-positive, alpha-beta T cell activation (GO:0035710)4.03656607
26positive regulation of granulocyte differentiation (GO:0030854)3.97809442
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.97306698
28positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.94742841
29mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.94742841
30negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.76570561
31tolerance induction (GO:0002507)3.75248034
32regulation of T cell receptor signaling pathway (GO:0050856)3.63787335
33B cell proliferation (GO:0042100)3.58311057
34cytokine biosynthetic process (GO:0042089)3.57916446
35autophagic vacuole fusion (GO:0000046)3.56273511
36ribosomal large subunit biogenesis (GO:0042273)3.49340141
37activated T cell proliferation (GO:0050798)3.47954021
38termination of RNA polymerase III transcription (GO:0006386)3.43114506
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.43114506
40mannosylation (GO:0097502)3.42690567
41CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.42667441
42protein localization to cilium (GO:0061512)3.37315351
43regulation of immunoglobulin secretion (GO:0051023)3.35324887
44histone H2B ubiquitination (GO:0033523)3.32720996
45positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.29510633
46nucleoside transmembrane transport (GO:1901642)3.28705676
47peptidyl-lysine methylation (GO:0018022)3.27534603
48peptidyl-histidine modification (GO:0018202)3.26937016
49negative thymic T cell selection (GO:0045060)3.25949909
50negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.22846261
51acrosome assembly (GO:0001675)3.10462073
52negative T cell selection (GO:0043383)3.09872307
53positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.09205455
54T cell proliferation (GO:0042098)3.07482327
55regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.07274688
56positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.07274688
57tyrosine phosphorylation of STAT protein (GO:0007260)3.06746066
58regulation of triglyceride biosynthetic process (GO:0010866)3.06601825
59negative regulation of T cell receptor signaling pathway (GO:0050860)3.06582968
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06387980
61cytokine metabolic process (GO:0042107)3.06182802
62positive regulation of triglyceride biosynthetic process (GO:0010867)3.05185259
63lymph node development (GO:0048535)3.05144421
64tRNA processing (GO:0008033)3.02530976
65cell fate commitment involved in formation of primary germ layer (GO:0060795)3.01210329
66mitochondrial RNA metabolic process (GO:0000959)2.97729816
67positive regulation of isotype switching (GO:0045830)2.96518171
68positive regulation of DNA recombination (GO:0045911)2.92334027
69regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.92073666
70positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.92073666
71regulation of receptor binding (GO:1900120)2.91470317
72positive regulation of organelle assembly (GO:1902117)2.90746640
73T cell activation involved in immune response (GO:0002286)2.89283457
74T cell differentiation (GO:0030217)2.88000279
75organelle membrane fusion (GO:0090174)2.85404896
76mature B cell differentiation (GO:0002335)2.82968161
77platelet dense granule organization (GO:0060155)2.81074097
78detection of light stimulus involved in visual perception (GO:0050908)2.76168710
79detection of light stimulus involved in sensory perception (GO:0050962)2.76168710
80regulation of translational termination (GO:0006449)2.71567756
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71553201
82positive regulation of mitochondrial membrane permeability (GO:0035794)2.68668878
83spermatid nucleus differentiation (GO:0007289)2.68300435
84regulation of gamma-delta T cell differentiation (GO:0045586)2.66424226
85regulation of vitamin D biosynthetic process (GO:0060556)2.65383538
86regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64931737
87auditory receptor cell differentiation (GO:0042491)2.64650025
88negative regulation of T-helper cell differentiation (GO:0045623)2.64414000
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64414000
90lymphocyte proliferation (GO:0046651)2.63460640
91tRNA metabolic process (GO:0006399)2.63305611
92protein K6-linked ubiquitination (GO:0085020)2.62557447
93positive regulation of immunoglobulin production (GO:0002639)2.61788033
94positive regulation of antigen processing and presentation (GO:0002579)2.61167766
95regulation of MHC class I biosynthetic process (GO:0045343)2.60866090
96lymphocyte activation involved in immune response (GO:0002285)2.60622951
97positive regulation of mRNA catabolic process (GO:0061014)2.59644071
98fucose catabolic process (GO:0019317)2.59626692
99L-fucose metabolic process (GO:0042354)2.59626692
100L-fucose catabolic process (GO:0042355)2.59626692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.28003806
2VDR_22108803_ChIP-Seq_LS180_Human3.75226329
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61546501
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.57589050
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46500564
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38770052
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.29389847
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.87745218
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65544443
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.50311181
11ZNF274_21170338_ChIP-Seq_K562_Hela2.45527013
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.44129051
13VDR_23849224_ChIP-Seq_CD4+_Human2.38897949
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.37544471
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33150226
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32342005
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29534854
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.28632444
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08933057
20FOXP3_21729870_ChIP-Seq_TREG_Human1.93180649
21GATA3_26560356_Chip-Seq_TH2_Human1.92700473
22IRF1_19129219_ChIP-ChIP_H3396_Human1.90943892
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84858121
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81866986
25MYB_26560356_Chip-Seq_TH2_Human1.73284456
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72165159
27RUNX_20019798_ChIP-Seq_JUKART_Human1.65891562
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58155340
29ELK1_19687146_ChIP-ChIP_HELA_Human1.57762133
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57297188
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.54719899
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53289389
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47938023
34HOXB7_26014856_ChIP-Seq_BT474_Human1.44130050
35P300_19829295_ChIP-Seq_ESCs_Human1.42930612
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40828590
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35667972
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35638546
39TAF15_26573619_Chip-Seq_HEK293_Human1.35228264
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34876339
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34645516
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29515781
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28339394
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.28219181
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27748564
46ER_23166858_ChIP-Seq_MCF-7_Human1.26608823
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.26273587
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25369955
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24100448
50GATA3_27048872_Chip-Seq_THYMUS_Human1.23308488
51VDR_24787735_ChIP-Seq_THP-1_Human1.22328903
52GATA3_26560356_Chip-Seq_TH1_Human1.21028825
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.19769573
54TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.19751148
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.19313964
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19313964
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.15842240
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12918896
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11217845
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.10398808
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09688088
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.09684382
63MYC_18940864_ChIP-ChIP_HL60_Human1.09547058
64MYC_19829295_ChIP-Seq_ESCs_Human1.09085804
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08840346
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05646450
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04109759
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04109759
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03277323
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02982806
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02213646
72TFEB_21752829_ChIP-Seq_HELA_Human1.01927639
73TTF2_22483619_ChIP-Seq_HELA_Human1.01554013
74KDM5A_27292631_Chip-Seq_BREAST_Human1.01527912
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01431556
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00176059
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00038529
78AR_20517297_ChIP-Seq_VCAP_Human0.98292715
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97085798
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96771941
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.96252199
82E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96167884
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94183608
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94069999
85IGF1R_20145208_ChIP-Seq_DFB_Human0.93206909
86NCOR_22424771_ChIP-Seq_293T_Human0.92742814
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91767287
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91422345
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91411439
90GABP_19822575_ChIP-Seq_HepG2_Human0.90802302
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90582270
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89918409
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89136417
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88575447
95GBX2_23144817_ChIP-Seq_PC3_Human0.87899753
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86100889
97CIITA_25753668_ChIP-Seq_RAJI_Human0.85062650
98EWS_26573619_Chip-Seq_HEK293_Human0.84825811
99CTCF_20526341_ChIP-Seq_ESCs_Human0.84299932
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.83168405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.17394013
2MP0005671_abnormal_response_to4.58357161
3MP0008057_abnormal_DNA_replication3.59875213
4MP0008875_abnormal_xenobiotic_pharmacok3.34109939
5MP0001348_abnormal_lacrimal_gland3.31701407
6MP0001835_abnormal_antigen_presentation2.98180675
7MP0001873_stomach_inflammation2.72970141
8MP0004142_abnormal_muscle_tone2.49543747
9MP0003806_abnormal_nucleotide_metabolis2.46443600
10MP0005085_abnormal_gallbladder_physiolo2.38045743
11MP0005310_abnormal_salivary_gland2.35925663
12MP0008872_abnormal_physiological_respon2.31559229
13MP0001800_abnormal_humoral_immune2.22032006
14MP0005075_abnormal_melanosome_morpholog2.21685545
15MP0001346_abnormal_lacrimal_gland2.15935376
16MP0003763_abnormal_thymus_physiology2.11983354
17MP0009333_abnormal_splenocyte_physiolog2.06795684
18MP0005084_abnormal_gallbladder_morpholo2.06060353
19MP0003646_muscle_fatigue1.99033773
20MP0001790_abnormal_immune_system1.91847195
21MP0005387_immune_system_phenotype1.91847195
22MP0003221_abnormal_cardiomyocyte_apopto1.91005457
23MP0005083_abnormal_biliary_tract1.88643829
24MP0002723_abnormal_immune_serum1.77133326
25MP0002638_abnormal_pupillary_reflex1.73317088
26MP0000685_abnormal_immune_system1.71056374
27MP0002138_abnormal_hepatobiliary_system1.69654988
28MP0005000_abnormal_immune_tolerance1.67922129
29MP0002277_abnormal_respiratory_mucosa1.64029482
30MP0002160_abnormal_reproductive_system1.63452532
31MP0003195_calcinosis1.63163260
32MP0002876_abnormal_thyroid_physiology1.59354459
33MP0002148_abnormal_hypersensitivity_rea1.59145111
34MP0003828_pulmonary_edema1.51161645
35MP0004147_increased_porphyrin_level1.47158368
36MP0002452_abnormal_antigen_presenting1.46741862
37MP0001905_abnormal_dopamine_level1.40531947
38MP0000749_muscle_degeneration1.38031195
39MP0002420_abnormal_adaptive_immunity1.37552408
40MP0005025_abnormal_response_to1.35890119
41MP0000703_abnormal_thymus_morphology1.33870684
42MP0001819_abnormal_immune_cell1.32411895
43MP0003866_abnormal_defecation1.30228796
44MP0004381_abnormal_hair_follicle1.29767835
45MP0002735_abnormal_chemical_nociception1.28774329
46MP0002102_abnormal_ear_morphology1.22190402
47MP0003693_abnormal_embryo_hatching1.15994957
48MP0000716_abnormal_immune_system1.14518117
49MP0002398_abnormal_bone_marrow1.13489999
50MP0009785_altered_susceptibility_to1.13438852
51MP0006082_CNS_inflammation1.13119363
52MP0000689_abnormal_spleen_morphology1.11396851
53MP0002163_abnormal_gland_morphology1.09799670
54MP0003172_abnormal_lysosome_physiology1.09501809
55MP0001501_abnormal_sleep_pattern1.07448525
56MP0003186_abnormal_redox_activity1.07065024
57MP0009745_abnormal_behavioral_response1.03568388
58MP0002166_altered_tumor_susceptibility1.03450840
59MP0001529_abnormal_vocalization1.02879454
60MP0005551_abnormal_eye_electrophysiolog1.02801613
61MP0003011_delayed_dark_adaptation1.01547250
62MP0000613_abnormal_salivary_gland0.99913285
63MP0006036_abnormal_mitochondrial_physio0.99073264
64MP0001919_abnormal_reproductive_system0.97939323
65MP0005645_abnormal_hypothalamus_physiol0.96948676
66MP0008058_abnormal_DNA_repair0.96176966
67MP0005389_reproductive_system_phenotype0.95674836
68MP0001663_abnormal_digestive_system0.94324578
69MP0002006_tumorigenesis0.92652834
70MP0002272_abnormal_nervous_system0.92650721
71MP0002429_abnormal_blood_cell0.89239706
72MP0001727_abnormal_embryo_implantation0.85947843
73MP0001845_abnormal_inflammatory_respons0.85276666
74MP0001440_abnormal_grooming_behavior0.82861634
75MP0005410_abnormal_fertilization0.80682428
76MP0001765_abnormal_ion_homeostasis0.80277534
77MP0003959_abnormal_lean_body0.78468407
78MP0005535_abnormal_body_temperature0.78231604
79MP0002405_respiratory_system_inflammati0.77086197
80MP0002733_abnormal_thermal_nociception0.76836472
81MP0002089_abnormal_postnatal_growth/wei0.74606907
82MP0008995_early_reproductive_senescence0.74593249
83MP0001970_abnormal_pain_threshold0.73576649
84MP0002722_abnormal_immune_system0.72118481
85MP0005377_hearing/vestibular/ear_phenot0.70841603
86MP0003878_abnormal_ear_physiology0.70841603
87MP0002693_abnormal_pancreas_physiology0.70473266
88MP0003567_abnormal_fetal_cardiomyocyte0.70313724
89MP0003787_abnormal_imprinting0.70215676
90MP0006035_abnormal_mitochondrial_morpho0.69722370
91MP0002229_neurodegeneration0.67519199
92MP0001177_atelectasis0.65708297
93MP0008961_abnormal_basal_metabolism0.65132209
94MP0005386_behavior/neurological_phenoty0.63485489
95MP0004924_abnormal_behavior0.63485489
96MP0004043_abnormal_pH_regulation0.63167794
97MP0000470_abnormal_stomach_morphology0.63063607
98MP0002419_abnormal_innate_immunity0.62349719
99MP0001764_abnormal_homeostasis0.60471636
100MP0010155_abnormal_intestine_physiology0.60306650

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)8.22374507
2Elevated erythrocyte sedimentation rate (HP:0003565)6.89399373
3Progressive inability to walk (HP:0002505)6.17541859
4Acute necrotizing encephalopathy (HP:0006965)4.44974491
5Axonal loss (HP:0003447)4.40169953
6Diaphragmatic weakness (HP:0009113)4.16341371
7Abnormal mitochondria in muscle tissue (HP:0008316)3.83962162
8Type II lissencephaly (HP:0007260)3.77609622
9Progressive macrocephaly (HP:0004481)3.68773654
10Type I transferrin isoform profile (HP:0003642)3.63170349
11Acute encephalopathy (HP:0006846)3.61240048
12IgG deficiency (HP:0004315)3.60190705
13Microvesicular hepatic steatosis (HP:0001414)3.52634712
14Large for gestational age (HP:0001520)3.49454712
15Mitochondrial inheritance (HP:0001427)3.42930131
16Increased CSF lactate (HP:0002490)3.38810960
17Cerebellar dysplasia (HP:0007033)3.38088367
18Inability to walk (HP:0002540)3.34146431
193-Methylglutaconic aciduria (HP:0003535)3.34133264
20Increased serum lactate (HP:0002151)3.25034274
21Hepatocellular necrosis (HP:0001404)3.16108816
22Mutism (HP:0002300)3.14750848
23Neonatal respiratory distress (HP:0002643)2.99855466
24Cerebral edema (HP:0002181)2.66592711
25Rib fusion (HP:0000902)2.58059461
26Abnormal albumin level (HP:0012116)2.56527747
27Hypoalbuminemia (HP:0003073)2.56527747
28Chronic mucocutaneous candidiasis (HP:0002728)2.56515068
29Recurrent cutaneous fungal infections (HP:0011370)2.56515068
30Congenital, generalized hypertrichosis (HP:0004540)2.56048293
31Abnormal protein glycosylation (HP:0012346)2.55431726
32Abnormal glycosylation (HP:0012345)2.55431726
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55431726
34Abnormal protein N-linked glycosylation (HP:0012347)2.55431726
35Hepatic necrosis (HP:0002605)2.53168573
36Abolished electroretinogram (ERG) (HP:0000550)2.52630189
37Male pseudohermaphroditism (HP:0000037)2.51131802
38Lactic acidosis (HP:0003128)2.46770881
39Abnormality of macular pigmentation (HP:0008002)2.43438680
40Tongue fasciculations (HP:0001308)2.39681203
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30970304
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30970304
43Chronic hepatic failure (HP:0100626)2.30284171
44Optic disc pallor (HP:0000543)2.29265314
45Shawl scrotum (HP:0000049)2.26709110
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24886047
47Lipid accumulation in hepatocytes (HP:0006561)2.18470136
48Long nose (HP:0003189)2.15502052
49Respiratory failure (HP:0002878)2.11353667
50Beaking of vertebral bodies (HP:0004568)2.09097620
51Muscle fibrillation (HP:0010546)2.08557847
52Medial flaring of the eyebrow (HP:0010747)2.08110090
53Increased IgM level (HP:0003496)2.06911339
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05962956
55Abnormality of alanine metabolism (HP:0010916)2.05962956
56Hyperalaninemia (HP:0003348)2.05962956
57Facial diplegia (HP:0001349)2.02005089
58Leukodystrophy (HP:0002415)2.01165207
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.00341802
60Pancytopenia (HP:0001876)1.99449593
61Anterior segment dysgenesis (HP:0007700)1.98118785
62Hypoplasia of the radius (HP:0002984)1.97862216
63Hypoproteinemia (HP:0003075)1.96643226
64Cheilitis (HP:0100825)1.95942092
65Ketoacidosis (HP:0001993)1.91825535
66Knee flexion contracture (HP:0006380)1.91631960
67Pancreatic cysts (HP:0001737)1.91187483
68Biliary tract neoplasm (HP:0100574)1.90362472
69Microcytic anemia (HP:0001935)1.90298046
70Lethargy (HP:0001254)1.90286048
71Methylmalonic acidemia (HP:0002912)1.89491087
72Cerebral hemorrhage (HP:0001342)1.88530273
73Neonatal hypoglycemia (HP:0001998)1.87810478
74X-linked dominant inheritance (HP:0001423)1.87348702
75Generalized amyotrophy (HP:0003700)1.86637840
76Increased hepatocellular lipid droplets (HP:0006565)1.80982475
77Alveolar cell carcinoma (HP:0006519)1.80567797
78Absent thumb (HP:0009777)1.79542799
79Mesomelia (HP:0003027)1.79329191
80Depressed nasal tip (HP:0000437)1.78290118
81Pendular nystagmus (HP:0012043)1.76747220
82Abnormality of methionine metabolism (HP:0010901)1.75766126
83Retinal dysplasia (HP:0007973)1.75605043
84Abnormal biliary tract physiology (HP:0012439)1.75288260
85Bile duct proliferation (HP:0001408)1.75288260
86Forearm undergrowth (HP:0009821)1.74964635
87Anxiety (HP:0000739)1.74802126
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72412245
89Attenuation of retinal blood vessels (HP:0007843)1.72032887
90CNS demyelination (HP:0007305)1.71339336
91Follicular hyperkeratosis (HP:0007502)1.70090971
92Mesangial abnormality (HP:0001966)1.69357010
93Hypoplasia of the pons (HP:0012110)1.67145457
94B lymphocytopenia (HP:0010976)1.66295972
95Vacuolated lymphocytes (HP:0001922)1.66096248
96Ketosis (HP:0001946)1.65844809
97Severe muscular hypotonia (HP:0006829)1.64276473
98Hypomagnesemia (HP:0002917)1.63655034
99Tetany (HP:0001281)1.62995932
100Abnormality of the pons (HP:0007361)1.60564323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TEC4.26623279
2MAPKAPK54.03924947
3ITK3.36994017
4TSSK63.32636517
5INSRR3.23709108
6VRK23.22907165
7EIF2AK33.17716031
8MST43.03273115
9VRK13.01036607
10TYRO32.90604051
11BMPR1B2.84517884
12TXK2.73934735
13PDK22.32084009
14IKBKB2.24058195
15PNCK2.09681858
16EIF2AK12.06458905
17MAP4K11.98284955
18ADRBK21.75776542
19BTK1.73089905
20BCKDK1.69168065
21ZAK1.68695511
22NUAK11.64942068
23TAOK31.53960404
24WEE11.47031876
25NLK1.46707224
26MUSK1.41602544
27TNIK1.38986543
28WNK31.38665153
29MAP3K121.37577404
30FES1.37166697
31GRK11.26714879
32CLK11.22089771
33WNK41.20246574
34SIK31.17977377
35MAP2K61.13517857
36CHUK1.12496722
37TIE11.10417411
38CCNB10.99570836
39PBK0.93309423
40LCK0.92727641
41TGFBR10.88578715
42PLK30.86974776
43STK38L0.86017851
44WNK10.85003521
45FRK0.81302872
46MAPK130.79535713
47IRAK10.75639961
48PINK10.72292909
49PASK0.69089332
50STK240.67767948
51IKBKE0.67384163
52PRKCQ0.66067160
53NEK10.65957869
54TLK10.65645334
55MAPK110.65287236
56LYN0.62367757
57MKNK20.58449868
58NME10.56976732
59GRK60.56593331
60PRKACG0.56367412
61BMPR20.56078434
62DAPK20.53264922
63HCK0.52584963
64EPHB20.52246683
65BRSK20.49745823
66STK30.47045597
67STK390.45669905
68TNK20.43529074
69BCR0.43379143
70BRD40.40640341
71RPS6KA50.39299017
72CSK0.39135177
73IRAK30.39104447
74RPS6KB10.38081268
75ADRBK10.37400949
76PRKCG0.37255879
77RPS6KB20.35753692
78CAMKK20.35228929
79IGF1R0.33911264
80PRKACA0.32325788
81MAPK150.32198055
82CSNK2A20.32068645
83MYLK0.31889045
84PRKCE0.31335996
85ACVR1B0.31103071
86MAPKAPK20.30698058
87MARK30.29378702
88KIT0.28452215
89PRKCD0.27822818
90NTRK20.26300910
91SYK0.24487906
92MAP3K140.23326070
93MAP2K30.22349687
94PIK3CG0.20517083
95STK40.19521335
96PRKCA0.19092949
97MELK0.16912863
98EIF2AK20.16693033
99ATM0.15350124
100PAK30.15169050

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.27756432
2Allograft rejection_Homo sapiens_hsa053302.96728198
3Asthma_Homo sapiens_hsa053102.95845967
4RNA polymerase_Homo sapiens_hsa030202.95396711
5Autoimmune thyroid disease_Homo sapiens_hsa053202.83753218
6Oxidative phosphorylation_Homo sapiens_hsa001902.80821711
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.75439056
8Proteasome_Homo sapiens_hsa030502.60161396
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32136705
10Parkinsons disease_Homo sapiens_hsa050122.31955544
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.19728937
12RNA degradation_Homo sapiens_hsa030182.18556034
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06682184
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06647284
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98256258
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97424071
17Cardiac muscle contraction_Homo sapiens_hsa042601.92984554
18Legionellosis_Homo sapiens_hsa051341.83139775
19Measles_Homo sapiens_hsa051621.81119892
20T cell receptor signaling pathway_Homo sapiens_hsa046601.69977115
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63335232
22Linoleic acid metabolism_Homo sapiens_hsa005911.57795373
23Alzheimers disease_Homo sapiens_hsa050101.55774216
24Caffeine metabolism_Homo sapiens_hsa002321.49530851
25Phototransduction_Homo sapiens_hsa047441.44852147
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44741686
27Huntingtons disease_Homo sapiens_hsa050161.44721740
28Spliceosome_Homo sapiens_hsa030401.43908359
29Sulfur metabolism_Homo sapiens_hsa009201.40264935
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.34012991
31Circadian rhythm_Homo sapiens_hsa047101.31606436
32Graft-versus-host disease_Homo sapiens_hsa053321.28166198
33Antigen processing and presentation_Homo sapiens_hsa046121.27882912
34Type I diabetes mellitus_Homo sapiens_hsa049401.26822694
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18300838
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13358273
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13261421
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11310663
39Homologous recombination_Homo sapiens_hsa034401.10775826
40Primary immunodeficiency_Homo sapiens_hsa053401.08778645
41Systemic lupus erythematosus_Homo sapiens_hsa053220.98324527
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95511859
43Hematopoietic cell lineage_Homo sapiens_hsa046400.94143842
44Epstein-Barr virus infection_Homo sapiens_hsa051690.93537126
45Basal transcription factors_Homo sapiens_hsa030220.92535355
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.89195520
47Butanoate metabolism_Homo sapiens_hsa006500.88210723
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87904568
49Influenza A_Homo sapiens_hsa051640.84965495
50Taste transduction_Homo sapiens_hsa047420.83953542
51Sulfur relay system_Homo sapiens_hsa041220.82373851
52Collecting duct acid secretion_Homo sapiens_hsa049660.81527906
53Fanconi anemia pathway_Homo sapiens_hsa034600.77281826
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76853416
55Selenocompound metabolism_Homo sapiens_hsa004500.76778543
56Purine metabolism_Homo sapiens_hsa002300.73269517
57Ribosome_Homo sapiens_hsa030100.73005823
58ABC transporters_Homo sapiens_hsa020100.72718244
59Nitrogen metabolism_Homo sapiens_hsa009100.70795812
60Rheumatoid arthritis_Homo sapiens_hsa053230.70717069
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70365390
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69586369
63Pyrimidine metabolism_Homo sapiens_hsa002400.68729195
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65977973
65Propanoate metabolism_Homo sapiens_hsa006400.61890670
66Regulation of autophagy_Homo sapiens_hsa041400.61800419
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.61376659
68Ether lipid metabolism_Homo sapiens_hsa005650.60825960
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.60011557
70RNA transport_Homo sapiens_hsa030130.59447732
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58369659
72Leishmaniasis_Homo sapiens_hsa051400.49170813
73Viral myocarditis_Homo sapiens_hsa054160.48313461
74Tryptophan metabolism_Homo sapiens_hsa003800.48265142
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47069049
76N-Glycan biosynthesis_Homo sapiens_hsa005100.44695790
77Pyruvate metabolism_Homo sapiens_hsa006200.39298914
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38371994
79Serotonergic synapse_Homo sapiens_hsa047260.36464599
80Metabolic pathways_Homo sapiens_hsa011000.33151696
81Ovarian steroidogenesis_Homo sapiens_hsa049130.32316308
82Toxoplasmosis_Homo sapiens_hsa051450.30241033
83Arachidonic acid metabolism_Homo sapiens_hsa005900.29954334
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29683809
85Chemical carcinogenesis_Homo sapiens_hsa052040.29444980
86Olfactory transduction_Homo sapiens_hsa047400.28944305
87Sphingolipid metabolism_Homo sapiens_hsa006000.27528817
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26729633
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26707895
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25630652
91Fatty acid degradation_Homo sapiens_hsa000710.25381316
92Viral carcinogenesis_Homo sapiens_hsa052030.25265085
93One carbon pool by folate_Homo sapiens_hsa006700.24797241
94MAPK signaling pathway_Homo sapiens_hsa040100.23730234
95Nicotine addiction_Homo sapiens_hsa050330.23487214
96Vitamin B6 metabolism_Homo sapiens_hsa007500.23066601
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22719165
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18081823
99Nucleotide excision repair_Homo sapiens_hsa034200.17988561
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17666161

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