CDC42P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1innate immune response in mucosa (GO:0002227)9.70351177
2mucosal immune response (GO:0002385)7.83146316
3antibacterial humoral response (GO:0019731)7.07581796
4organ or tissue specific immune response (GO:0002251)7.00576895
5antimicrobial humoral response (GO:0019730)6.43469599
6nucleosome assembly (GO:0006334)5.50178528
7immunoglobulin mediated immune response (GO:0016064)5.43378140
8chromatin assembly (GO:0031497)5.26102995
9DNA replication-dependent nucleosome organization (GO:0034723)4.90577269
10DNA replication-dependent nucleosome assembly (GO:0006335)4.90577269
11protein-DNA complex assembly (GO:0065004)4.89710101
12DNA deamination (GO:0045006)4.86862423
13B cell mediated immunity (GO:0019724)4.62357717
14nucleosome organization (GO:0034728)4.45842014
15negative regulation of B cell proliferation (GO:0030889)4.42232239
16positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.39240528
17T-helper 1 type immune response (GO:0042088)4.34696959
18positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.33160784
19protein-DNA complex subunit organization (GO:0071824)4.08556602
20negative regulation of B cell apoptotic process (GO:0002903)3.74527230
21establishment of viral latency (GO:0019043)3.74134829
22B cell proliferation (GO:0042100)3.70056807
23antigen processing and presentation of endogenous antigen (GO:0019883)3.62240593
24interferon-gamma-mediated signaling pathway (GO:0060333)3.62033184
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.57661366
26NADH dehydrogenase complex assembly (GO:0010257)3.57661366
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57661366
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56725496
29negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.51804723
30positive regulation of macrophage cytokine production (GO:0060907)3.46348647
31positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42579862
32regulation of interferon-gamma biosynthetic process (GO:0045072)3.42021458
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36909269
34viral mRNA export from host cell nucleus (GO:0046784)3.33992548
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32703385
36regulation of isotype switching to IgG isotypes (GO:0048302)3.32061097
37regulation of B cell proliferation (GO:0030888)3.31823359
38ATP synthesis coupled proton transport (GO:0015986)3.30306559
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30306559
40regulation of B cell receptor signaling pathway (GO:0050855)3.24731422
41protein complex biogenesis (GO:0070271)3.23389369
42establishment of integrated proviral latency (GO:0075713)3.20778182
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19968155
44B cell homeostasis (GO:0001782)3.19935075
45production of molecular mediator of immune response (GO:0002440)3.18618729
46positive regulation of prostaglandin secretion (GO:0032308)3.16693321
47regulation of B cell apoptotic process (GO:0002902)3.15141931
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13752400
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13046736
50proteasome assembly (GO:0043248)3.12724881
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12329330
52lymphocyte costimulation (GO:0031294)3.08568034
53positive regulation of humoral immune response (GO:0002922)3.08551735
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08216115
55B cell receptor signaling pathway (GO:0050853)3.07151678
56regulation of prostaglandin secretion (GO:0032306)3.02699866
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99929903
58T cell costimulation (GO:0031295)2.98661403
59mitochondrial respiratory chain complex assembly (GO:0033108)2.97912838
60negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.95682148
61defense response to Gram-positive bacterium (GO:0050830)2.95636640
62positive regulation of immunoglobulin mediated immune response (GO:0002891)2.94592527
63positive regulation of B cell mediated immunity (GO:0002714)2.94592527
64cellular response to interleukin-15 (GO:0071350)2.93443663
65regulation of immunoglobulin secretion (GO:0051023)2.92585405
66regulation of protein heterodimerization activity (GO:0043497)2.91334625
67regulation of T cell mediated cytotoxicity (GO:0001914)2.89124132
68cytidine metabolic process (GO:0046087)2.87713611
69cytidine catabolic process (GO:0006216)2.87713611
70cytidine deamination (GO:0009972)2.87713611
71antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.86161585
72respiratory electron transport chain (GO:0022904)2.84958252
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.82068902
74detection of bacterium (GO:0016045)2.81278012
75lymphocyte mediated immunity (GO:0002449)2.78286641
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78207954
77positive regulation of DNA recombination (GO:0045911)2.77618114
78electron transport chain (GO:0022900)2.77091484
79iron-sulfur cluster assembly (GO:0016226)2.75014915
80metallo-sulfur cluster assembly (GO:0031163)2.75014915
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74315936
82positive regulation of cell killing (GO:0031343)2.74033320
83release of cytochrome c from mitochondria (GO:0001836)2.73360746
84positive regulation of B cell proliferation (GO:0030890)2.72660459
85protein maturation by protein folding (GO:0022417)2.72148391
86chromatin assembly or disassembly (GO:0006333)2.71992611
87negative T cell selection (GO:0043383)2.71547269
88adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.69822020
89positive regulation of alpha-beta T cell proliferation (GO:0046641)2.69194656
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68844236
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67444848
92cellular response to interferon-gamma (GO:0071346)2.66558685
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66109117
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.64777858
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64777858
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64770740
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64031003
98humoral immune response (GO:0006959)2.63588262
99positive regulation of immunoglobulin production (GO:0002639)2.63510973
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62882427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.23623486
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.51351491
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41355580
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99069379
5SOX2_16153702_ChIP-ChIP_HESCs_Human2.87679564
6RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.77888950
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.76041610
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75145114
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51972314
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.45669929
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.43816443
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.33209295
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25102849
14HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.21551645
15IRF1_19129219_ChIP-ChIP_H3396_Human2.20705105
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17635779
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15495289
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13551772
19ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.12578355
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12277564
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05984710
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00244333
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.7337803
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98953490
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97694059
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96060903
27VDR_23849224_ChIP-Seq_CD4+_Human1.91213309
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86000134
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82203409
30E2F7_22180533_ChIP-Seq_HELA_Human1.72712024
31CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.70873666
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67759896
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.64638935
34ELK1_19687146_ChIP-ChIP_HELA_Human1.62228572
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60833630
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54474661
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.50424885
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50051630
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49886528
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45168088
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44459012
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43279710
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.39809208
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39397469
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36570174
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.36522468
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35196118
48CIITA_25753668_ChIP-Seq_RAJI_Human1.32645307
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32330382
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.31892885
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31600535
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29580135
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29348782
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.27270860
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26772458
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26746065
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26133697
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25756269
59GATA1_22025678_ChIP-Seq_K562_Human1.24497214
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.21267862
61MYC_18940864_ChIP-ChIP_HL60_Human1.17097599
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14138030
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12102045
64MAF_26560356_Chip-Seq_TH1_Human1.11240047
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11143145
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.10771404
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10567180
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10368401
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07907745
70FOXP3_21729870_ChIP-Seq_TREG_Human1.04256014
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.03165770
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02474557
73DCP1A_22483619_ChIP-Seq_HELA_Human0.96164544
74ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95326359
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.94797106
76SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94261020
77MYB_26560356_Chip-Seq_TH2_Human0.89913356
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88643050
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.83477619
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83294955
81SPI1_20517297_ChIP-Seq_HL60_Human0.81837826
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81597145
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81540665
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80465662
85XRN2_22483619_ChIP-Seq_HELA_Human0.79997318
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78663381
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77130701
88MYB_26560356_Chip-Seq_TH1_Human0.74662895
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69710973
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67430561
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.66799311
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.65655019
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.65500258
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.64273399
95BP1_19119308_ChIP-ChIP_Hs578T_Human0.64204611
96GABP_19822575_ChIP-Seq_HepG2_Human0.63779613
97VDR_21846776_ChIP-Seq_THP-1_Human0.63594490
98BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63131464
99BCL6_27268052_Chip-Seq_Bcells_Human0.59990395
100P300_27268052_Chip-Seq_Bcells_Human0.57523605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol6.76780788
2MP0000685_abnormal_immune_system4.94885353
3MP0005671_abnormal_response_to4.79181858
4MP0001835_abnormal_antigen_presentation3.40387905
5MP0001790_abnormal_immune_system3.16920981
6MP0005387_immune_system_phenotype3.16920981
7MP0009046_muscle_twitch3.15359150
8MP0001800_abnormal_humoral_immune3.11889639
9MP0001348_abnormal_lacrimal_gland2.61213925
10MP0003763_abnormal_thymus_physiology2.53511581
11MP0005000_abnormal_immune_tolerance2.39584257
12MP0003122_maternal_imprinting2.37530645
13MP0001529_abnormal_vocalization2.34611533
14MP0002166_altered_tumor_susceptibility2.27234855
15MP0002452_abnormal_antigen_presenting2.04227144
16MP0005084_abnormal_gallbladder_morpholo2.01110736
17MP0002723_abnormal_immune_serum1.95576192
18MP0010094_abnormal_chromosome_stability1.89417640
19MP0002006_tumorigenesis1.73753042
20MP0002138_abnormal_hepatobiliary_system1.71593538
21MP0002420_abnormal_adaptive_immunity1.69581372
22MP0008872_abnormal_physiological_respon1.65220467
23MP0008875_abnormal_xenobiotic_pharmacok1.64764677
24MP0009785_altered_susceptibility_to1.63506065
25MP0001819_abnormal_immune_cell1.61398346
26MP0003183_abnormal_peptide_metabolism1.57662697
27MP0001873_stomach_inflammation1.54498738
28MP0003806_abnormal_nucleotide_metabolis1.53363163
29MP0006276_abnormal_autonomic_nervous1.52397794
30MP0005025_abnormal_response_to1.48263402
31MP0001919_abnormal_reproductive_system1.47864934
32MP0001984_abnormal_olfaction1.46603173
33MP0005623_abnormal_meninges_morphology1.46203011
34MP0000372_irregular_coat_pigmentation1.45347762
35MP0002398_abnormal_bone_marrow1.41839174
36MP0000716_abnormal_immune_system1.41513953
37MP0002148_abnormal_hypersensitivity_rea1.39684550
38MP0008058_abnormal_DNA_repair1.32775194
39MP0004142_abnormal_muscle_tone1.30298725
40MP0002009_preneoplasia1.28815330
41MP0003121_genomic_imprinting1.28784869
42MP0003077_abnormal_cell_cycle1.24312431
43MP0002102_abnormal_ear_morphology1.21656483
44MP0001727_abnormal_embryo_implantation1.18254695
45MP0002429_abnormal_blood_cell1.14386450
46MP0006072_abnormal_retinal_apoptosis1.13677188
47MP0000689_abnormal_spleen_morphology1.13262909
48MP0001502_abnormal_circadian_rhythm1.10600565
49MP0001905_abnormal_dopamine_level1.07024459
50MP0004145_abnormal_muscle_electrophysio1.06656336
51MP0002722_abnormal_immune_system1.06145078
52MP0001845_abnormal_inflammatory_respons1.05727247
53MP0001440_abnormal_grooming_behavior1.04438916
54MP0003186_abnormal_redox_activity1.00409458
55MP0003950_abnormal_plasma_membrane0.98582744
56MP0000631_abnormal_neuroendocrine_gland0.97199873
57MP0003283_abnormal_digestive_organ0.95798050
58MP0003329_amyloid_beta_deposits0.91349844
59MP0000749_muscle_degeneration0.89657361
60MP0003111_abnormal_nucleus_morphology0.89444148
61MP0005386_behavior/neurological_phenoty0.85143579
62MP0004924_abnormal_behavior0.85143579
63MP0003436_decreased_susceptibility_to0.82955664
64MP0002653_abnormal_ependyma_morphology0.80981580
65MP0005166_decreased_susceptibility_to0.79428019
66MP0002419_abnormal_innate_immunity0.77116950
67MP0005253_abnormal_eye_physiology0.76652634
68MP0000747_muscle_weakness0.76534699
69MP0003303_peritoneal_inflammation0.75274093
70MP0002557_abnormal_social/conspecific_i0.75041610
71MP0009745_abnormal_behavioral_response0.74866836
72MP0000026_abnormal_inner_ear0.74016462
73MP0005423_abnormal_somatic_nervous0.73125259
74MP0001881_abnormal_mammary_gland0.73102908
75MP0003315_abnormal_perineum_morphology0.72740951
76MP0005310_abnormal_salivary_gland0.72033683
77MP0002019_abnormal_tumor_incidence0.70864288
78MP0000750_abnormal_muscle_regeneration0.70637721
79MP0010155_abnormal_intestine_physiology0.68371752
80MP0004957_abnormal_blastocyst_morpholog0.67134640
81MP0004859_abnormal_synaptic_plasticity0.66960270
82MP0005389_reproductive_system_phenotype0.64954248
83MP0008469_abnormal_protein_level0.64836980
84MP0004742_abnormal_vestibular_system0.64471747
85MP0000343_altered_response_to0.63326529
86MP0008569_lethality_at_weaning0.63180461
87MP0001663_abnormal_digestive_system0.62905265
88MP0002272_abnormal_nervous_system0.62204914
89MP0009643_abnormal_urine_homeostasis0.60530046
90MP0000639_abnormal_adrenal_gland0.60310799
91MP0002139_abnormal_hepatobiliary_system0.60057097
92MP0000465_gastrointestinal_hemorrhage0.59719893
93MP0009763_increased_sensitivity_to0.57401711
94MP0002332_abnormal_exercise_endurance0.57248513
95MP0000703_abnormal_thymus_morphology0.56728599
96MP0009333_abnormal_splenocyte_physiolog0.53307546
97MP0000604_amyloidosis0.52420637
98MP0001853_heart_inflammation0.52017156
99MP0005330_cardiomyopathy0.51236996
100MP0004272_abnormal_basement_membrane0.50808192

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.67583246
2IgA deficiency (HP:0002720)5.87598435
3Recurrent sinusitis (HP:0011108)5.32267415
4Recurrent bronchitis (HP:0002837)5.16268769
5IgM deficiency (HP:0002850)5.11128928
6IgG deficiency (HP:0004315)4.15797207
7Mitochondrial inheritance (HP:0001427)4.14411113
8Lymphopenia (HP:0001888)4.09875221
9Hepatocellular necrosis (HP:0001404)3.98738517
10Abnormal mitochondria in muscle tissue (HP:0008316)3.84496695
11Emphysema (HP:0002097)3.79973874
12Abnormality of cells of the lymphoid lineage (HP:0012140)3.79948002
13Vasculitis (HP:0002633)3.78226010
14Increased CSF lactate (HP:0002490)3.75412386
15Acute necrotizing encephalopathy (HP:0006965)3.73749137
16Hepatic necrosis (HP:0002605)3.72403657
17Agammaglobulinemia (HP:0004432)3.70146486
18Dry hair (HP:0011359)3.63159048
19Increased hepatocellular lipid droplets (HP:0006565)3.62966579
20Lipid accumulation in hepatocytes (HP:0006561)3.53863355
21Urticaria (HP:0001025)3.38955220
22Restrictive lung disease (HP:0002091)3.26079858
23Renal Fanconi syndrome (HP:0001994)3.20969669
24Meningitis (HP:0001287)3.20019005
25Palpebral edema (HP:0100540)3.13711449
26Progressive macrocephaly (HP:0004481)3.11435459
27Acute encephalopathy (HP:0006846)3.08840747
28Increased intramyocellular lipid droplets (HP:0012240)3.07496700
29Increased IgM level (HP:0003496)2.95801166
30Recurrent pneumonia (HP:0006532)2.95344912
31Abnormality of the prostate (HP:0008775)2.91407242
32Chronic diarrhea (HP:0002028)2.90024204
333-Methylglutaconic aciduria (HP:0003535)2.84346409
34Mediastinal lymphadenopathy (HP:0100721)2.84268492
35Calf muscle hypertrophy (HP:0008981)2.80618216
36Bronchitis (HP:0012387)2.78057698
37Onycholysis (HP:0001806)2.77110682
38Increased serum lactate (HP:0002151)2.76695329
39Abnormality of glycolysis (HP:0004366)2.74415663
40Conical tooth (HP:0000698)2.70698649
41Increased muscle lipid content (HP:0009058)2.70647212
42Abnormal gallbladder physiology (HP:0012438)2.59488753
43Cholecystitis (HP:0001082)2.59488753
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58099938
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58099938
46Squamous cell carcinoma (HP:0002860)2.56563823
47Cerebral edema (HP:0002181)2.54110880
48Exertional dyspnea (HP:0002875)2.51968575
49Recurrent lower respiratory tract infections (HP:0002783)2.48870576
50Skin rash (HP:0000988)2.46225643
51Hypertensive crisis (HP:0100735)2.45804994
52Muscle hypertrophy of the lower extremities (HP:0008968)2.45160589
53Periorbital edema (HP:0100539)2.38274605
54Cellulitis (HP:0100658)2.35603153
55Abnormality of T cell physiology (HP:0011840)2.35401476
56Lactic acidosis (HP:0003128)2.34159113
57Increased serum pyruvate (HP:0003542)2.32207576
58Facial edema (HP:0000282)2.30817527
59Exercise-induced muscle cramps (HP:0003710)2.30411565
60Xerostomia (HP:0000217)2.29104597
61Lissencephaly (HP:0001339)2.28114915
62Degeneration of anterior horn cells (HP:0002398)2.26209336
63Abnormality of the anterior horn cell (HP:0006802)2.26209336
64Exercise intolerance (HP:0003546)2.23676824
65Leukopenia (HP:0001882)2.18493316
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17234891
67Recurrent otitis media (HP:0000403)2.16889437
68Large eyes (HP:0001090)2.12559228
69Respiratory failure (HP:0002878)2.12352884
70Erythema (HP:0010783)2.11937582
71Myoglobinuria (HP:0002913)2.09817370
72Obstructive lung disease (HP:0006536)2.06132427
73Chronic obstructive pulmonary disease (HP:0006510)2.06132427
74Abnormality of male internal genitalia (HP:0000022)2.05809839
75Prostate neoplasm (HP:0100787)2.03335455
76Shoulder girdle muscle weakness (HP:0003547)2.03271467
77Pelvic girdle muscle weakness (HP:0003749)2.00590143
78Pulmonary infiltrates (HP:0002113)2.00414647
79Severe muscular hypotonia (HP:0006829)1.98786085
80Lymphoma (HP:0002665)1.98571978
81Eczematoid dermatitis (HP:0000976)1.98354166
82Recurrent bacterial skin infections (HP:0005406)1.97357861
83Ridged nail (HP:0001807)1.96409105
84Death in childhood (HP:0003819)1.96155136
85Hypoplasia of the uterus (HP:0000013)1.96153245
86Aplasia/hypoplasia of the uterus (HP:0008684)1.93726542
87Abnormality of incisor morphology (HP:0011063)1.91644614
88Abnormality of the pleura (HP:0002103)1.90122296
89Verrucae (HP:0200043)1.87107224
90Papilloma (HP:0012740)1.87107224
91Basal cell carcinoma (HP:0002671)1.85506848
92Emotional lability (HP:0000712)1.82804873
93Respiratory difficulties (HP:0002880)1.82291907
94Osteomyelitis (HP:0002754)1.81880689
95Leukodystrophy (HP:0002415)1.80904906
96Arthralgia (HP:0002829)1.80487262
97Hypoplasia of the thymus (HP:0000778)1.80323647
98Hypoplasia of the pons (HP:0012110)1.79496546
99Pulmonary fibrosis (HP:0002206)1.78996532
100Gliosis (HP:0002171)1.75075143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.38505145
2ZAK7.17607867
3VRK17.05993445
4DAPK33.61029427
5VRK22.89366623
6RPS6KA52.86609616
7AURKA2.54446066
8TAF11.75742582
9BCKDK1.72356050
10BUB11.60520587
11MUSK1.56492001
12TESK21.54184401
13SMG11.36744807
14MST41.32315271
15TESK11.31499806
16MAPKAPK51.28884957
17PKN11.22405857
18MARK11.15500485
19BLK1.11228170
20CHEK21.09568430
21STK41.08159584
22CCNB11.05206065
23AURKB1.04434063
24SIK31.01494393
25PIM21.00454469
26LIMK10.97988654
27IRAK40.97432678
28CSNK1G30.96951113
29BCR0.96647986
30CSNK1G20.91740135
31DYRK20.91072309
32MAP3K120.90169443
33SYK0.90081803
34ARAF0.89761222
35CSNK1A1L0.89033136
36NEK90.87621498
37MAP4K10.86419705
38CDK80.83045598
39PIM10.80872942
40NEK10.77541793
41TNIK0.72148571
42AKT20.70551631
43UHMK10.70110212
44IKBKB0.67704361
45SRPK10.67222635
46LYN0.65466926
47CDK90.63591287
48NME20.60107853
49CSNK1G10.58911158
50KDR0.58183787
51PRKCQ0.57350584
52PBK0.55683299
53MAP2K70.53565177
54IKBKE0.47637551
55NUAK10.46054060
56BTK0.45552235
57CDK190.44182211
58CSF1R0.42717140
59HIPK20.41570010
60RIPK40.41243349
61PRKCD0.40609358
62TBK10.40356364
63CDK180.37852214
64SIK20.36683954
65CDK150.36435290
66CDK140.35640002
67DAPK10.34829771
68CDK11A0.33326461
69CDC70.32339980
70TRIM280.32147430
71WNK30.31666176
72PAK40.29548640
73DYRK1B0.29188965
74PHKG20.28416880
75PHKG10.28416880
76MAPKAPK30.27208601
77TXK0.26800428
78STK100.26751070
79TNK20.26737014
80MAP4K20.26576587
81MAPK110.25348676
82ADRBK20.25173839
83CSNK2A20.24939554
84MAPK130.23789075
85GRK50.23604370
86OXSR10.22559120
87ERN10.22340830
88ALK0.21740445
89EPHA30.21652327
90ROCK10.19391427
91MAPK120.19340089
92PAK10.19303371
93RPS6KB20.19245697
94ABL10.19240190
95MAP3K140.18500325
96MOS0.18032834
97KIT0.17651423
98CSNK2A10.16186368
99MINK10.15090614
100PLK10.14115665

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053229.08693862
2Alcoholism_Homo sapiens_hsa050346.04583115
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.64777446
4Asthma_Homo sapiens_hsa053103.52668544
5Allograft rejection_Homo sapiens_hsa053303.42003953
6Autoimmune thyroid disease_Homo sapiens_hsa053203.26649261
7Graft-versus-host disease_Homo sapiens_hsa053322.56786599
8Viral carcinogenesis_Homo sapiens_hsa052032.53351194
9Type I diabetes mellitus_Homo sapiens_hsa049402.42803746
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38923511
11Viral myocarditis_Homo sapiens_hsa054162.17804387
12Primary immunodeficiency_Homo sapiens_hsa053402.05126571
13Oxidative phosphorylation_Homo sapiens_hsa001901.95959704
14Proteasome_Homo sapiens_hsa030501.78636889
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78623516
16Parkinsons disease_Homo sapiens_hsa050121.67911745
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53229338
18Antigen processing and presentation_Homo sapiens_hsa046121.41869325
19Leishmaniasis_Homo sapiens_hsa051401.18385992
20Rheumatoid arthritis_Homo sapiens_hsa053231.17572290
21Alzheimers disease_Homo sapiens_hsa050101.16012753
22Huntingtons disease_Homo sapiens_hsa050161.05646720
23DNA replication_Homo sapiens_hsa030300.98658793
24Staphylococcus aureus infection_Homo sapiens_hsa051500.98345579
25Sulfur relay system_Homo sapiens_hsa041220.91681765
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84511258
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80509147
28Cardiac muscle contraction_Homo sapiens_hsa042600.78130477
29Mismatch repair_Homo sapiens_hsa034300.74278241
30Spliceosome_Homo sapiens_hsa030400.74055979
31Epstein-Barr virus infection_Homo sapiens_hsa051690.73998381
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72699068
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70956582
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70881605
35B cell receptor signaling pathway_Homo sapiens_hsa046620.69288917
36Phagosome_Homo sapiens_hsa041450.66672086
37Ribosome_Homo sapiens_hsa030100.63054594
38Herpes simplex infection_Homo sapiens_hsa051680.63036280
39Hematopoietic cell lineage_Homo sapiens_hsa046400.62857426
40Phenylalanine metabolism_Homo sapiens_hsa003600.62523198
41Pentose phosphate pathway_Homo sapiens_hsa000300.58722468
42p53 signaling pathway_Homo sapiens_hsa041150.55339847
43Carbon metabolism_Homo sapiens_hsa012000.52473722
44Biosynthesis of amino acids_Homo sapiens_hsa012300.52214961
45Nucleotide excision repair_Homo sapiens_hsa034200.51875007
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51768428
47Homologous recombination_Homo sapiens_hsa034400.50918361
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50672756
49Base excision repair_Homo sapiens_hsa034100.50308413
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.49935857
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49451650
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46820259
53Tryptophan metabolism_Homo sapiens_hsa003800.42344686
54Vibrio cholerae infection_Homo sapiens_hsa051100.41325618
55Tuberculosis_Homo sapiens_hsa051520.41152739
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37675650
57Influenza A_Homo sapiens_hsa051640.37465185
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36581984
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35415955
60Protein export_Homo sapiens_hsa030600.34982360
61HTLV-I infection_Homo sapiens_hsa051660.34570167
62Pyruvate metabolism_Homo sapiens_hsa006200.34058410
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32018714
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.31561895
65One carbon pool by folate_Homo sapiens_hsa006700.31527099
66Toxoplasmosis_Homo sapiens_hsa051450.30804328
67Tyrosine metabolism_Homo sapiens_hsa003500.30801367
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28825313
69RNA degradation_Homo sapiens_hsa030180.28609091
70Pyrimidine metabolism_Homo sapiens_hsa002400.28380822
71RNA polymerase_Homo sapiens_hsa030200.28300842
72Collecting duct acid secretion_Homo sapiens_hsa049660.27533528
73Non-homologous end-joining_Homo sapiens_hsa034500.26951341
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.25778455
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24732292
76Fatty acid elongation_Homo sapiens_hsa000620.22941892
77Fructose and mannose metabolism_Homo sapiens_hsa000510.22339307
78Measles_Homo sapiens_hsa051620.19714760
79Cell cycle_Homo sapiens_hsa041100.15236895
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.14516580
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14036825
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13390543
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.10319235
84Glutathione metabolism_Homo sapiens_hsa004800.09338589
85Salmonella infection_Homo sapiens_hsa051320.08201833
86Basal transcription factors_Homo sapiens_hsa030220.07993296
87Synaptic vesicle cycle_Homo sapiens_hsa047210.07957921
88RNA transport_Homo sapiens_hsa030130.06573851
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06511068
90Fanconi anemia pathway_Homo sapiens_hsa034600.05830317
91Shigellosis_Homo sapiens_hsa051310.04156017
92Oocyte meiosis_Homo sapiens_hsa041140.03830268
93Apoptosis_Homo sapiens_hsa042100.03433705
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02654858
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01898635
96Galactose metabolism_Homo sapiens_hsa000520.01884555
97Arginine and proline metabolism_Homo sapiens_hsa003300.01789876
98Butanoate metabolism_Homo sapiens_hsa006500.01479158
99Propanoate metabolism_Homo sapiens_hsa006400.01084352
100Steroid biosynthesis_Homo sapiens_hsa001000.00635498

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