CDC42SE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.98297993
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.98297993
3antigen processing and presentation of endogenous antigen (GO:0019883)5.65192125
4positive regulation of gamma-delta T cell activation (GO:0046645)5.22810663
5detection of other organism (GO:0098543)4.52049173
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40627677
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39877428
8negative regulation of cell killing (GO:0031342)4.39877428
9macrophage activation involved in immune response (GO:0002281)4.38997508
10leukocyte aggregation (GO:0070486)4.34151864
11detection of bacterium (GO:0016045)4.33932785
12positive thymic T cell selection (GO:0045059)4.30826628
13negative thymic T cell selection (GO:0045060)4.24151863
14negative T cell selection (GO:0043383)4.23978099
15negative regulation of lymphocyte mediated immunity (GO:0002707)4.23076386
16regulation of gamma-delta T cell differentiation (GO:0045586)4.17607192
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.10246391
18regulation of B cell receptor signaling pathway (GO:0050855)3.93293135
19negative regulation of T cell mediated immunity (GO:0002710)3.93182928
20response to peptidoglycan (GO:0032494)3.91752774
21regulation of interferon-beta biosynthetic process (GO:0045357)3.88115508
22detection of external biotic stimulus (GO:0098581)3.84538660
23regulation of gamma-delta T cell activation (GO:0046643)3.84054411
24thymic T cell selection (GO:0045061)3.80680445
25negative regulation of leukocyte mediated immunity (GO:0002704)3.74951720
26detection of molecule of bacterial origin (GO:0032490)3.68396938
27T cell migration (GO:0072678)3.53043217
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52634287
29response to host immune response (GO:0052572)3.52634287
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49294208
31microglial cell activation (GO:0001774)3.46770316
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45233047
33myeloid cell activation involved in immune response (GO:0002275)3.45166217
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42054422
35detection of biotic stimulus (GO:0009595)3.34902457
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.34222376
37T cell selection (GO:0045058)3.33944807
38positive T cell selection (GO:0043368)3.32492102
39positive regulation of lamellipodium assembly (GO:0010592)3.31518705
40response to host (GO:0075136)3.30097821
41response to host defenses (GO:0052200)3.30097821
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30097821
43regulation of regulatory T cell differentiation (GO:0045589)3.29641959
44response to interleukin-15 (GO:0070672)3.29408848
45regulation of T cell mediated cytotoxicity (GO:0001914)3.28967965
46regulation of B cell differentiation (GO:0045577)3.27425410
47immunoglobulin mediated immune response (GO:0016064)3.27376054
48hepatocyte apoptotic process (GO:0097284)3.27096822
49leukocyte cell-cell adhesion (GO:0007159)3.23927850
50antigen processing and presentation via MHC class Ib (GO:0002475)3.23569651
51B cell receptor signaling pathway (GO:0050853)3.22820257
52regulation of mast cell degranulation (GO:0043304)3.17939520
53macrophage activation (GO:0042116)3.17845997
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16857606
55production of molecular mediator involved in inflammatory response (GO:0002532)3.16518502
56cellular extravasation (GO:0045123)3.14633366
57interferon-gamma production (GO:0032609)3.14412666
58neutrophil mediated immunity (GO:0002446)3.13140338
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10962926
60endothelial tube morphogenesis (GO:0061154)3.09271028
61morphogenesis of an endothelium (GO:0003159)3.09271028
62positive regulation of mast cell activation (GO:0033005)3.08330588
63leukocyte degranulation (GO:0043299)3.07746119
64regulation of T cell tolerance induction (GO:0002664)3.07423295
65tolerance induction (GO:0002507)3.07304726
66leukocyte migration involved in inflammatory response (GO:0002523)3.05030993
67NIK/NF-kappaB signaling (GO:0038061)3.03292082
68defense response to protozoan (GO:0042832)3.02684644
69negative regulation of T-helper cell differentiation (GO:0045623)3.02442317
70negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02442317
71dendritic cell chemotaxis (GO:0002407)3.01451188
72germinal center formation (GO:0002467)3.01363893
73neutrophil activation involved in immune response (GO:0002283)3.01138331
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00646944
75T cell costimulation (GO:0031295)2.99822281
76dendritic cell migration (GO:0036336)2.98974011
77positive regulation of B cell differentiation (GO:0045579)2.96383502
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95824931
79actin nucleation (GO:0045010)2.94476236
80lymphocyte costimulation (GO:0031294)2.93767061
81positive regulation of granulocyte differentiation (GO:0030854)2.92047993
82positive regulation of lamellipodium organization (GO:1902745)2.91354000
83regulation of mast cell activation involved in immune response (GO:0033006)2.90215388
84negative regulation of innate immune response (GO:0045824)2.89852403
85interferon-gamma secretion (GO:0072643)2.89727504
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89480038
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.89331851
88regulation of mast cell activation (GO:0033003)2.89136020
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86823521
90cellular response to interleukin-15 (GO:0071350)2.85987095
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83982871
92cellular response to zinc ion (GO:0071294)2.83199581
93antigen receptor-mediated signaling pathway (GO:0050851)2.79775940
94B cell mediated immunity (GO:0019724)2.78684916
95T cell receptor signaling pathway (GO:0050852)2.78403906
96natural killer cell differentiation (GO:0001779)2.77934372
97response to type I interferon (GO:0034340)2.77812105
98negative regulation of phagocytosis (GO:0050765)2.77003540
99regulation of response to interferon-gamma (GO:0060330)2.76585674
100interferon-gamma-mediated signaling pathway (GO:0060333)2.75663182
101neutrophil activation (GO:0042119)2.74819412
102barbed-end actin filament capping (GO:0051016)2.74333628
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74058722
104type I interferon signaling pathway (GO:0060337)2.73227277
105cellular response to type I interferon (GO:0071357)2.73227277
106positive regulation of tolerance induction (GO:0002645)2.72317190
107negative regulation of erythrocyte differentiation (GO:0045647)2.71998747
108positive regulation of isotype switching (GO:0045830)2.71500768
109sequestering of actin monomers (GO:0042989)2.71497234
110regulation of alpha-beta T cell proliferation (GO:0046640)2.68102507
111regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.67849081
112establishment of endothelial barrier (GO:0061028)2.65595031
113regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64840425
114response to muramyl dipeptide (GO:0032495)2.63703890
115positive regulation by symbiont of host defense response (GO:0052509)2.63202563
116modulation by symbiont of host defense response (GO:0052031)2.63202563
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63202563
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63202563
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.63202563
120modulation by symbiont of host immune response (GO:0052553)2.63202563
121negative regulation of interleukin-12 production (GO:0032695)2.61324264
122regulation of tolerance induction (GO:0002643)2.58574721
123granulocyte activation (GO:0036230)2.54320197
124regulation of isotype switching to IgG isotypes (GO:0048302)2.53885502
125myeloid dendritic cell activation (GO:0001773)2.53789973
126positive regulation of antigen processing and presentation (GO:0002579)2.53115385
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52906787
128regulation of natural killer cell mediated immunity (GO:0002715)2.52906787
129viral transcription (GO:0019083)2.51868411
130immune response-activating cell surface receptor signaling pathway (GO:0002429)2.51579233
131angiogenesis involved in wound healing (GO:0060055)2.51008656
132response to laminar fluid shear stress (GO:0034616)2.49383212
133activated T cell proliferation (GO:0050798)2.48783080
134natural killer cell activation (GO:0030101)2.47752219
135respiratory burst (GO:0045730)2.47249650
136pinocytosis (GO:0006907)2.46927535
137heterotypic cell-cell adhesion (GO:0034113)2.46044526
138regulation of T cell receptor signaling pathway (GO:0050856)2.45633193
139ribosomal small subunit assembly (GO:0000028)2.44895894
140mast cell activation (GO:0045576)2.44882599
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44855141
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43929908
143myeloid dendritic cell differentiation (GO:0043011)2.43768436
144T cell proliferation (GO:0042098)2.42674197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88154471
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49997210
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.43101281
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.40153458
5MYC_22102868_ChIP-Seq_BL_Human3.20390253
6E2F7_22180533_ChIP-Seq_HELA_Human2.96213843
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94208831
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84628366
9* IRF8_21731497_ChIP-ChIP_J774_Mouse2.77222531
10VDR_21846776_ChIP-Seq_THP-1_Human2.70667808
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56187032
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.50365781
13* MAF_26560356_Chip-Seq_TH1_Human2.48283936
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43974284
15* MYB_26560356_Chip-Seq_TH2_Human2.34260580
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33409531
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23657021
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19353872
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18325185
20UTX_26944678_Chip-Seq_JUKART_Human2.17550973
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17500684
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.16907367
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10677651
24RUNX_20019798_ChIP-Seq_JUKART_Human2.03995059
25TCF7_22412390_ChIP-Seq_EML_Mouse2.03161974
26VDR_24763502_ChIP-Seq_THP-1_Human1.98924479
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98304404
28* MYB_26560356_Chip-Seq_TH1_Human1.97777754
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96146507
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95005599
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94874407
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93435882
33* SPI1_23547873_ChIP-Seq_NB4_Human1.92733951
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92702878
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.91146813
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.85714284
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84869529
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.83945383
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.83723880
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82301996
41SCL_19346495_ChIP-Seq_HPC-7_Human1.80572696
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77435199
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76651054
44* KDM2B_26808549_Chip-Seq_DND41_Human1.74526805
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67264560
46VDR_24787735_ChIP-Seq_THP-1_Human1.65824157
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64607171
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63056749
49* MAF_26560356_Chip-Seq_TH2_Human1.60268882
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57910805
51SPI1_23127762_ChIP-Seq_K562_Human1.52839574
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48562116
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45662740
54GATA3_26560356_Chip-Seq_TH2_Human1.44399549
55GATA3_27048872_Chip-Seq_THYMUS_Human1.38682189
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36819304
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.36687127
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34966707
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33917620
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28915813
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28914115
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26715997
63LXR_22292898_ChIP-Seq_THP-1_Human1.22474716
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21818340
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20094403
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19244664
67GATA1_19941826_ChIP-Seq_K562_Human1.18765702
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18267541
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16978191
70PU_27001747_Chip-Seq_BMDM_Mouse1.16332013
71GATA1_22025678_ChIP-Seq_K562_Human1.15095032
72* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14407058
73NCOR1_26117541_ChIP-Seq_K562_Human1.13289590
74* RACK7_27058665_Chip-Seq_MCF-7_Human1.12801938
75* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11104026
76* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10771873
77CIITA_25753668_ChIP-Seq_RAJI_Human1.10545076
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.07773918
79* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06706586
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06117111
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06080907
82CLOCK_20551151_ChIP-Seq_293T_Human1.06076909
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04835895
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04398458
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04266315
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04220666
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04024790
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03242986
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.02930001
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02401993
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00584508
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98018488
93GATA2_19941826_ChIP-Seq_K562_Human0.97735309
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96442996
95TFEB_21752829_ChIP-Seq_HELA_Human0.95884720
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95679608
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95017263
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94619565
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94106126
100ATF3_27146783_Chip-Seq_COLON_Human0.94095868
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93624240
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93291467
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91901915
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91746176
105BCL6_27268052_Chip-Seq_Bcells_Human0.90806083
106* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90607188
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90500334
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89759623
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89669296
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.89611466
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87851684
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.86587933
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86360728
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85411653
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85220308
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85083400
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84606537
118BCOR_27268052_Chip-Seq_Bcells_Human0.84603798
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.84233816
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83441060
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82995902
122* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82626938
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82299059
124XRN2_22483619_ChIP-Seq_HELA_Human0.80678178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.27133149
2MP0000685_abnormal_immune_system3.21536551
3MP0003763_abnormal_thymus_physiology2.85935234
4MP0003436_decreased_susceptibility_to2.83465041
5MP0003303_peritoneal_inflammation2.81776463
6MP0005671_abnormal_response_to2.63064837
7MP0005387_immune_system_phenotype2.62191517
8MP0001790_abnormal_immune_system2.62191517
9MP0001800_abnormal_humoral_immune2.57377537
10MP0003300_gastrointestinal_ulcer2.54554373
11MP0005000_abnormal_immune_tolerance2.45484216
12MP0002452_abnormal_antigen_presenting2.38413741
13MP0002420_abnormal_adaptive_immunity2.33383785
14MP0001819_abnormal_immune_cell2.31508721
15MP0009785_altered_susceptibility_to2.30076378
16MP0005025_abnormal_response_to2.24906625
17MP0002723_abnormal_immune_serum2.23392215
18MP0002398_abnormal_bone_marrow2.14366191
19MP0009333_abnormal_splenocyte_physiolog2.11027981
20MP0002419_abnormal_innate_immunity2.10374256
21MP0002405_respiratory_system_inflammati2.10083142
22MP0002166_altered_tumor_susceptibility2.04967835
23MP0002148_abnormal_hypersensitivity_rea2.02624016
24MP0004947_skin_inflammation1.99874818
25MP0010352_gastrointestinal_tract_polyps1.96221424
26MP0009278_abnormal_bone_marrow1.94130794
27MP0000716_abnormal_immune_system1.91742603
28MP0002396_abnormal_hematopoietic_system1.90635060
29MP0001873_stomach_inflammation1.90426377
30MP0004381_abnormal_hair_follicle1.90343931
31MP0006082_CNS_inflammation1.88619432
32MP0010155_abnormal_intestine_physiology1.87715465
33MP0002722_abnormal_immune_system1.75628272
34MP0008260_abnormal_autophagy1.74050928
35MP0000689_abnormal_spleen_morphology1.73842412
36MP0005464_abnormal_platelet_physiology1.72339424
37MP0003566_abnormal_cell_adhesion1.69838773
38MP0000858_altered_metastatic_potential1.66820278
39MP0002429_abnormal_blood_cell1.65678846
40MP0002006_tumorigenesis1.65049190
41MP0010234_abnormal_vibrissa_follicle1.62783655
42MP0005397_hematopoietic_system_phenotyp1.60582946
43MP0001545_abnormal_hematopoietic_system1.60582946
44MP0000703_abnormal_thymus_morphology1.60196789
45MP0005076_abnormal_cell_differentiation1.59161152
46MP0004808_abnormal_hematopoietic_stem1.57414730
47MP0001845_abnormal_inflammatory_respons1.56078499
48MP0002933_joint_inflammation1.52869997
49MP0003448_altered_tumor_morphology1.51111379
50MP0005058_abnormal_lysosome_morphology1.49940328
51MP0001533_abnormal_skeleton_physiology1.48617792
52MP0001853_heart_inflammation1.47462209
53MP0006054_spinal_hemorrhage1.46113949
54MP0005451_abnormal_body_composition1.45154586
55MP0000465_gastrointestinal_hemorrhage1.44773637
56MP0003724_increased_susceptibility_to1.43472894
57MP0003866_abnormal_defecation1.42795654
58MP0000490_abnormal_crypts_of1.35468158
59MP0004510_myositis1.34240067
60MP0009764_decreased_sensitivity_to1.32399495
61MP0005310_abnormal_salivary_gland1.31862447
62MP0004883_abnormal_blood_vessel1.31098827
63MP0005023_abnormal_wound_healing1.30254265
64MP0003453_abnormal_keratinocyte_physiol1.29017971
65MP0002277_abnormal_respiratory_mucosa1.26576189
66MP0003705_abnormal_hypodermis_morpholog1.26359986
67MP0001958_emphysema1.17168609
68MP0001851_eye_inflammation1.12400280
69MP0005075_abnormal_melanosome_morpholog1.11076791
70MP0000343_altered_response_to1.10008716
71MP0003091_abnormal_cell_migration1.04424444
72MP0003045_fibrosis1.02980809
73MP0002019_abnormal_tumor_incidence1.02524160
74MP0008469_abnormal_protein_level1.01498041
75MP0010307_abnormal_tumor_latency0.98797644
76MP0002009_preneoplasia0.98638755
77MP0003172_abnormal_lysosome_physiology0.97820476
78MP0002138_abnormal_hepatobiliary_system0.95892634
79MP0004185_abnormal_adipocyte_glucose0.95627378
80MP0005164_abnormal_response_to0.94701692
81MP0003690_abnormal_glial_cell0.89292843
82MP0003191_abnormal_cellular_cholesterol0.89020742
83MP0002998_abnormal_bone_remodeling0.88411720
84MP0003075_altered_response_to0.87402463
85MP0005166_decreased_susceptibility_to0.87107667
86MP0001216_abnormal_epidermal_layer0.84426721
87MP0001348_abnormal_lacrimal_gland0.82106700
88MP0009763_increased_sensitivity_to0.81955033
89MP0003279_aneurysm0.81771363
90MP0002877_abnormal_melanocyte_morpholog0.80730086
91MP0004130_abnormal_muscle_cell0.80693287
92MP0002254_reproductive_system_inflammat0.78776509
93MP0002136_abnormal_kidney_physiology0.76507589
94MP0004957_abnormal_blastocyst_morpholog0.75647922
95MP0003795_abnormal_bone_structure0.75136591
96MP0000733_abnormal_muscle_development0.74862094
97MP0003077_abnormal_cell_cycle0.74729633
98MP0003656_abnormal_erythrocyte_physiolo0.74492030
99MP0003693_abnormal_embryo_hatching0.71641525
100MP0001915_intracranial_hemorrhage0.71611385
101MP0000377_abnormal_hair_follicle0.70527949
102MP0005390_skeleton_phenotype0.70022285
103MP0000604_amyloidosis0.69198816
104MP0000477_abnormal_intestine_morphology0.68838893
105MP0009765_abnormal_xenobiotic_induced0.68602702
106MP0002796_impaired_skin_barrier0.68246534
107MP0002132_abnormal_respiratory_system0.66889782
108MP0003183_abnormal_peptide_metabolism0.66756666
109MP0000015_abnormal_ear_pigmentation0.66569664
110MP0009931_abnormal_skin_appearance0.65856892
111MP0008007_abnormal_cellular_replicative0.65834271
112MP0005501_abnormal_skin_physiology0.64979952
113MP0001663_abnormal_digestive_system0.64834481
114MP0008438_abnormal_cutaneous_collagen0.64302264
115MP0005174_abnormal_tail_pigmentation0.63597297
116MP0008961_abnormal_basal_metabolism0.63527331
117MP0003828_pulmonary_edema0.62483882
118MP0000249_abnormal_blood_vessel0.62401836
119MP0005621_abnormal_cell_physiology0.62347663
120MP0001986_abnormal_taste_sensitivity0.59867452
121MP0008874_decreased_physiological_sensi0.56316246
122MP0008004_abnormal_stomach_pH0.55091033
123MP0003221_abnormal_cardiomyocyte_apopto0.52770824
124MP0002693_abnormal_pancreas_physiology0.52326634
125MP0004264_abnormal_extraembryonic_tissu0.50518407
126MP0002133_abnormal_respiratory_system0.46208005
127MP0005388_respiratory_system_phenotype0.46208005
128MP0002332_abnormal_exercise_endurance0.42046952
129MP0004484_altered_response_of0.40269518

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.52733876
2Recurrent abscess formation (HP:0002722)4.41317745
3Elevated erythrocyte sedimentation rate (HP:0003565)4.25312897
4Chronic otitis media (HP:0000389)4.07387859
5Recurrent fungal infections (HP:0002841)3.73500038
6Encephalitis (HP:0002383)3.73377873
7Nasal polyposis (HP:0100582)3.71130937
8Recurrent bacterial skin infections (HP:0005406)3.69575653
9Myositis (HP:0100614)3.66903351
10Keratoconjunctivitis sicca (HP:0001097)3.60125564
11Recurrent bronchitis (HP:0002837)3.57605162
12Recurrent viral infections (HP:0004429)3.55147421
13Pustule (HP:0200039)3.51153889
14Abnormality of the nasal mucosa (HP:0000433)3.50471996
15IgM deficiency (HP:0002850)3.48995561
16T lymphocytopenia (HP:0005403)3.44813420
17Abnormality of T cell number (HP:0011839)3.42321688
18Keratoconjunctivitis (HP:0001096)3.35145706
19Interstitial pulmonary disease (HP:0006530)3.27303035
20Cellulitis (HP:0100658)3.18720483
21Abnormality of T cells (HP:0002843)3.03423153
22Abnormality of macrophages (HP:0004311)2.96978940
23Autoimmune thrombocytopenia (HP:0001973)2.94735134
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.87804789
25Gastrointestinal inflammation (HP:0004386)2.86833727
26Increased IgE level (HP:0003212)2.85830213
27Recurrent cutaneous fungal infections (HP:0011370)2.85244404
28Chronic mucocutaneous candidiasis (HP:0002728)2.85244404
29Spontaneous hematomas (HP:0007420)2.84847352
30Inflammation of the large intestine (HP:0002037)2.83555735
31Recurrent skin infections (HP:0001581)2.79335322
32Mediastinal lymphadenopathy (HP:0100721)2.73546186
33Increased IgM level (HP:0003496)2.72718780
34Thrombocytosis (HP:0001894)2.69587062
35Colitis (HP:0002583)2.64618652
36Hypochromic anemia (HP:0001931)2.62366915
37Anorexia (HP:0002039)2.61474907
38Gingival bleeding (HP:0000225)2.61311460
39Pulmonary embolism (HP:0002204)2.59409317
40Panhypogammaglobulinemia (HP:0003139)2.57376567
41Hypochromic microcytic anemia (HP:0004840)2.57324688
42Verrucae (HP:0200043)2.55152188
43Papilloma (HP:0012740)2.55152188
44Meningitis (HP:0001287)2.55036250
45Agammaglobulinemia (HP:0004432)2.54438804
46Epistaxis (HP:0000421)2.54268547
47Petechiae (HP:0000967)2.53110240
48Abnormality of T cell physiology (HP:0011840)2.51135123
49Orchitis (HP:0100796)2.50772521
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.49192723
51Hematochezia (HP:0002573)2.48584630
52Lymphopenia (HP:0001888)2.47241315
53Episodic fever (HP:0001954)2.47174075
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.46649507
55Obstructive lung disease (HP:0006536)2.46516603
56Chronic obstructive pulmonary disease (HP:0006510)2.46516603
57Leukocytosis (HP:0001974)2.41455916
58Vasculitis (HP:0002633)2.37544139
59Vacuolated lymphocytes (HP:0001922)2.37055258
60Cerebral aneurysm (HP:0004944)2.33837689
61Slow saccadic eye movements (HP:0000514)2.33233681
62Gangrene (HP:0100758)2.30441365
63Emphysema (HP:0002097)2.26353377
64Recurrent gram-negative bacterial infections (HP:0005420)2.25313445
65Abnormality of the pleura (HP:0002103)2.24754799
66Skin ulcer (HP:0200042)2.23189303
67Osteolytic defects of the hand bones (HP:0009699)2.22615560
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.22615560
69Stomatitis (HP:0010280)2.20256674
70Combined immunodeficiency (HP:0005387)2.20171997
71Increased cerebral lipofuscin (HP:0011813)2.20076768
72Eosinophilia (HP:0001880)2.19580479
73Fatigue (HP:0012378)2.17705489
74Periodontitis (HP:0000704)2.17275616
75Gingivitis (HP:0000230)2.12932990
76Increased density of long bones (HP:0006392)2.11290438
77Hypergammaglobulinemia (HP:0010702)2.11072703
78Gastrointestinal stroma tumor (HP:0100723)2.10409193
79Dysostosis multiplex (HP:0000943)2.08186443
80Microcytic anemia (HP:0001935)2.06184912
81Subacute progressive viral hepatitis (HP:0006572)2.05909354
82Bronchitis (HP:0012387)2.05097273
83Severe combined immunodeficiency (HP:0004430)2.04584467
84Chest pain (HP:0100749)2.04545881
85Arterial thrombosis (HP:0004420)2.03324954
86Glomerulopathy (HP:0100820)2.00952886
87Urticaria (HP:0001025)1.98882010
88Granulocytopenia (HP:0001913)1.98102324
89Abnormality of the peritoneum (HP:0002585)1.97561308
90Aortic aneurysm (HP:0004942)1.97492380
91Abnormality of the fingertips (HP:0001211)1.97364570
92Abnormality of the endocardium (HP:0004306)1.97233997
93Abnormality of eosinophils (HP:0001879)1.96990744
94Optic neuritis (HP:0100653)1.96832809
95Retrobulbar optic neuritis (HP:0100654)1.96832809
96Joint swelling (HP:0001386)1.96315859
97IgG deficiency (HP:0004315)1.95467414
98Autoimmune hemolytic anemia (HP:0001890)1.93912346
99Papilledema (HP:0001085)1.93820058
100Chronic diarrhea (HP:0002028)1.93653282
101Osteomyelitis (HP:0002754)1.92025709
102Keratitis (HP:0000491)1.91517389
103Vertigo (HP:0002321)1.89779321
104Premature loss of primary teeth (HP:0006323)1.89707776
105Acute hepatic failure (HP:0006554)1.88699767
106Acne (HP:0001061)1.88058746
107Chronic sinusitis (HP:0011109)1.87667365
108Hemoptysis (HP:0002105)1.87011974
109Amyloidosis (HP:0011034)1.86162068
110Increased neuronal autofluorescent lipopigment (HP:0002074)1.85895706
111IgA deficiency (HP:0002720)1.85082650
112Persistence of primary teeth (HP:0006335)1.84628586
113Loss of speech (HP:0002371)1.84021832
114Thyroiditis (HP:0100646)1.83900189
115Pulmonary infiltrates (HP:0002113)1.82037260
116Abnormality of the pericardium (HP:0001697)1.81995990
117Gastrointestinal infarctions (HP:0005244)1.81186442
118Prolonged bleeding time (HP:0003010)1.79656802
119Peritonitis (HP:0002586)1.79280812
120Skin rash (HP:0000988)1.77429776
121Viral hepatitis (HP:0006562)1.75856287
122Impaired platelet aggregation (HP:0003540)1.73383251
123Abnormal platelet function (HP:0011869)1.73383251
124Bicuspid aortic valve (HP:0001647)1.72625506
125Sepsis (HP:0100806)1.72620754
126Thin bony cortex (HP:0002753)1.71775117
127Abnormality of B cell number (HP:0010975)1.69327170
128B lymphocytopenia (HP:0010976)1.69327170
129Abnormal platelet volume (HP:0011876)1.67404213
130Restrictive lung disease (HP:0002091)1.67251473
131Mucopolysacchariduria (HP:0008155)1.66313659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.16737008
2TRIB33.24505853
3STK103.22379298
4PRPF4B2.71426275
5TYK22.43671792
6ERN12.41269663
7LRRK22.37848390
8EEF2K2.34968784
9BLK2.34408572
10ZAP702.33459105
11MAP3K102.29249793
12JAK32.27103522
13PKN22.08276763
14TBK11.96359136
15TXK1.95292598
16EPHB11.94006676
17ITK1.89393486
18GRK61.88142820
19TNK21.87549769
20TESK21.84434508
21FGFR41.83012301
22TAOK31.80695179
23BTK1.72654670
24CSK1.69988128
25IKBKE1.62493766
26SIK31.56221101
27JAK11.49262900
28MAP3K141.48439604
29TGFBR21.46779557
30IRAK41.46727207
31MST41.45172015
32RPS6KA41.44224044
33KIT1.39699501
34PTK61.39249566
35TESK11.28518322
36CSF1R1.24365537
37RIPK11.23046356
38NME21.20923638
39PAK41.18033105
40HCK1.17468511
41LCK1.15987222
42FGFR31.14922371
43MAP3K11.14380663
44SYK1.10941851
45TEC1.10775899
46KSR21.10325961
47MAP3K131.08281366
48KDR1.07899559
49BMPR21.07395691
50PIM11.05702890
51FLT31.05558973
52YES11.04896365
53IKBKB1.04390278
54MAP2K31.02370329
55MAP3K81.02273719
56TTN1.01235358
57EPHA31.00767954
58PIM20.99933343
59CLK10.97345251
60NLK0.95921580
61MARK20.95281045
62MARK30.94101257
63IRAK10.88597438
64PDK10.84925201
65CHUK0.80495063
66SMG10.80427138
67RPS6KB20.80119733
68DMPK0.77676381
69JAK20.75106376
70CDK120.74522489
71CAMKK10.72188433
72MAP3K20.71053607
73MAP3K30.70442597
74SCYL20.69534367
75CAMKK20.69460018
76CDC42BPA0.69433115
77LYN0.69381826
78FES0.67783398
79IRAK20.67445628
80RIPK40.67413669
81MAP3K70.67200757
82NEK20.66721147
83CDK40.66388103
84MAP3K110.65595743
85TGFBR10.64613050
86FYN0.64553378
87TAOK10.64093873
88TAOK20.64041476
89PDGFRB0.63461981
90PDPK10.62636528
91ILK0.62250322
92FGR0.62094855
93MAPK120.62060159
94TYRO30.61640561
95ALK0.60803744
96CDK60.60130944
97DYRK1B0.60018940
98MAPK70.60007028
99PTK20.59770105
100MAPKAPK30.59663442
101STK40.59377947
102TRPM70.58687129
103MAP3K60.57166496
104MATK0.56182790
105PIK3CG0.55992916
106MAPKAPK20.55193288
107BMX0.54212288
108SGK30.53225765
109RET0.51977910
110GRK70.51719919
111STK380.49767734
112PTK2B0.49088502
113PRKCQ0.48836300
114SIK10.47750002
115HIPK20.46304871
116NEK90.45733383
117MAP2K20.44650410
118PRKCH0.44495520
119RPS6KC10.42705186
120RPS6KL10.42705186
121STK110.41907870
122PDGFRA0.41525110
123MAP2K60.41263777
124MAPK110.39179329
125RAF10.37567855
126PASK0.36391020
127PRKD20.35142799
128SGK20.35075325
129SIK20.34312068
130EGFR0.32952551
131DYRK30.31542412
132ABL10.31514249
133STK30.30011657
134RPS6KA60.29922878
135IRAK30.29682387
136LIMK10.29279868
137STK240.28912020

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.00259823
2Leishmaniasis_Homo sapiens_hsa051402.47371077
3Antigen processing and presentation_Homo sapiens_hsa046122.28405710
4B cell receptor signaling pathway_Homo sapiens_hsa046622.19715021
5Osteoclast differentiation_Homo sapiens_hsa043802.05667445
6Measles_Homo sapiens_hsa051622.05473635
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.03572192
8T cell receptor signaling pathway_Homo sapiens_hsa046601.98231158
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95165731
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94169490
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85393142
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.84633885
13Shigellosis_Homo sapiens_hsa051311.82701661
14Type I diabetes mellitus_Homo sapiens_hsa049401.80798708
15Toxoplasmosis_Homo sapiens_hsa051451.80012754
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.79736077
17Viral myocarditis_Homo sapiens_hsa054161.72192157
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70632323
19Hematopoietic cell lineage_Homo sapiens_hsa046401.67163541
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54236957
21Chronic myeloid leukemia_Homo sapiens_hsa052201.53615145
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53075634
23Acute myeloid leukemia_Homo sapiens_hsa052211.47870381
24Pancreatic cancer_Homo sapiens_hsa052121.47722261
25Legionellosis_Homo sapiens_hsa051341.47027560
26Apoptosis_Homo sapiens_hsa042101.46919374
27Herpes simplex infection_Homo sapiens_hsa051681.46651534
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42665634
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.40838839
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39135969
31Hepatitis B_Homo sapiens_hsa051611.35140516
32Chemokine signaling pathway_Homo sapiens_hsa040621.34806876
33Tuberculosis_Homo sapiens_hsa051521.34280667
34Graft-versus-host disease_Homo sapiens_hsa053321.33353798
35Influenza A_Homo sapiens_hsa051641.31821640
36Pertussis_Homo sapiens_hsa051331.29626207
37Small cell lung cancer_Homo sapiens_hsa052221.27828777
38Allograft rejection_Homo sapiens_hsa053301.24568910
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23942225
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23774111
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22722193
42TNF signaling pathway_Homo sapiens_hsa046681.20226322
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19932913
44Salmonella infection_Homo sapiens_hsa051321.17030920
45VEGF signaling pathway_Homo sapiens_hsa043701.15421963
46Malaria_Homo sapiens_hsa051441.14434060
47Other glycan degradation_Homo sapiens_hsa005111.12149909
48Platelet activation_Homo sapiens_hsa046111.10488917
49Lysosome_Homo sapiens_hsa041421.06075397
50Staphylococcus aureus infection_Homo sapiens_hsa051501.03784806
51Colorectal cancer_Homo sapiens_hsa052101.02096257
52Viral carcinogenesis_Homo sapiens_hsa052031.01811256
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.01687098
54HTLV-I infection_Homo sapiens_hsa051661.00684006
55Ribosome_Homo sapiens_hsa030100.99174792
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98946214
57Epstein-Barr virus infection_Homo sapiens_hsa051690.98575882
58Hepatitis C_Homo sapiens_hsa051600.97418699
59African trypanosomiasis_Homo sapiens_hsa051430.97028930
60Notch signaling pathway_Homo sapiens_hsa043300.96257662
61p53 signaling pathway_Homo sapiens_hsa041150.95627376
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95372953
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.91919357
64Non-small cell lung cancer_Homo sapiens_hsa052230.89368908
65Proteoglycans in cancer_Homo sapiens_hsa052050.84495427
66Adherens junction_Homo sapiens_hsa045200.84244806
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82515946
68Endocytosis_Homo sapiens_hsa041440.82330238
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81716766
70Focal adhesion_Homo sapiens_hsa045100.80689495
71Prolactin signaling pathway_Homo sapiens_hsa049170.79921823
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79227062
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78826407
74MicroRNAs in cancer_Homo sapiens_hsa052060.78234819
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76842432
76DNA replication_Homo sapiens_hsa030300.75344632
77Amoebiasis_Homo sapiens_hsa051460.74449578
78Autoimmune thyroid disease_Homo sapiens_hsa053200.74373273
79Choline metabolism in cancer_Homo sapiens_hsa052310.73358325
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72613244
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.72113234
82Endometrial cancer_Homo sapiens_hsa052130.70060910
83Asthma_Homo sapiens_hsa053100.68112064
84Bladder cancer_Homo sapiens_hsa052190.66015227
85Renal cell carcinoma_Homo sapiens_hsa052110.65484209
86Dorso-ventral axis formation_Homo sapiens_hsa043200.64773602
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.63997860
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63964204
89Base excision repair_Homo sapiens_hsa034100.62141084
90Inositol phosphate metabolism_Homo sapiens_hsa005620.61827437
91GnRH signaling pathway_Homo sapiens_hsa049120.59813851
92Thyroid cancer_Homo sapiens_hsa052160.59219505
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55661505
94Type II diabetes mellitus_Homo sapiens_hsa049300.55637374
95MAPK signaling pathway_Homo sapiens_hsa040100.55389262
96HIF-1 signaling pathway_Homo sapiens_hsa040660.55144395
97Pathways in cancer_Homo sapiens_hsa052000.55130346
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54967565
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54312604
100Spliceosome_Homo sapiens_hsa030400.54232569
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54094258
102ErbB signaling pathway_Homo sapiens_hsa040120.52928537
103Prostate cancer_Homo sapiens_hsa052150.52513854
104Cell cycle_Homo sapiens_hsa041100.51704356
105mTOR signaling pathway_Homo sapiens_hsa041500.49733957
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47979205
107ECM-receptor interaction_Homo sapiens_hsa045120.47344382
108FoxO signaling pathway_Homo sapiens_hsa040680.46956544
109Phagosome_Homo sapiens_hsa041450.46710524
110Rap1 signaling pathway_Homo sapiens_hsa040150.44330788
111Insulin resistance_Homo sapiens_hsa049310.43962672
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41775946
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.40872906
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38967540
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38606219
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38241559
117Glioma_Homo sapiens_hsa052140.38034962
118Rheumatoid arthritis_Homo sapiens_hsa053230.37591310
119Ras signaling pathway_Homo sapiens_hsa040140.37423337
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.37090876

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