CDC42SE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92932205
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71563423
3regulation of gamma-delta T cell differentiation (GO:0045586)4.61573201
4antigen processing and presentation of endogenous antigen (GO:0019883)4.54527176
5regulation of gamma-delta T cell activation (GO:0046643)4.42600285
6regulation of regulatory T cell differentiation (GO:0045589)4.31469846
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25418548
8regulation of alpha-beta T cell proliferation (GO:0046640)4.04181733
9positive regulation of alpha-beta T cell proliferation (GO:0046641)3.94117245
10negative regulation of T cell mediated immunity (GO:0002710)3.74081064
11tolerance induction (GO:0002507)3.61668190
12interferon-gamma production (GO:0032609)3.61348652
13regulation of T cell mediated cytotoxicity (GO:0001914)3.56562315
14cytidine deamination (GO:0009972)3.55430198
15cytidine metabolic process (GO:0046087)3.55430198
16cytidine catabolic process (GO:0006216)3.55430198
17positive regulation of B cell differentiation (GO:0045579)3.52246140
18regulation of B cell differentiation (GO:0045577)3.49347011
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49320296
20positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44097909
21pyrimidine ribonucleoside catabolic process (GO:0046133)3.42549081
22negative regulation of cell killing (GO:0031342)3.41288297
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41288297
24DNA deamination (GO:0045006)3.36569961
25immunoglobulin mediated immune response (GO:0016064)3.35236437
26negative regulation of lymphocyte mediated immunity (GO:0002707)3.32282790
27regulation of natural killer cell mediated immunity (GO:0002715)3.31915273
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.31915273
29regulation of T cell receptor signaling pathway (GO:0050856)3.29245053
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.26280571
31regulation of T cell tolerance induction (GO:0002664)3.25869763
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.25507894
33type I interferon signaling pathway (GO:0060337)3.22541258
34cellular response to type I interferon (GO:0071357)3.22541258
35response to type I interferon (GO:0034340)3.18513546
36neutrophil activation involved in immune response (GO:0002283)3.14394754
37dendritic cell chemotaxis (GO:0002407)3.11802028
38antigen processing and presentation via MHC class Ib (GO:0002475)3.10302678
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08579773
40dendritic cell migration (GO:0036336)3.06182823
41regulation of cell killing (GO:0031341)3.05503625
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05491927
43positive regulation of natural killer cell mediated immunity (GO:0002717)3.03618317
44interferon-gamma-mediated signaling pathway (GO:0060333)3.03303280
45activated T cell proliferation (GO:0050798)2.98611210
46positive regulation of cell killing (GO:0031343)2.98321441
47neutrophil activation (GO:0042119)2.97810178
48regulation of tolerance induction (GO:0002643)2.97522377
49B cell mediated immunity (GO:0019724)2.97491319
50positive regulation of tolerance induction (GO:0002645)2.93845519
51positive regulation of interleukin-2 production (GO:0032743)2.91484630
52negative regulation of leukocyte mediated immunity (GO:0002704)2.91408424
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90131876
54negative regulation of T-helper cell differentiation (GO:0045623)2.90131876
55regulation of interleukin-2 biosynthetic process (GO:0045076)2.87636942
56cellular extravasation (GO:0045123)2.85753887
57negative T cell selection (GO:0043383)2.85598349
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84337622
59negative thymic T cell selection (GO:0045060)2.81977164
60leukocyte degranulation (GO:0043299)2.80556539
61negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80454056
62alpha-beta T cell differentiation (GO:0046632)2.80135373
63neuron cell-cell adhesion (GO:0007158)2.78671444
64regulation of meiosis (GO:0040020)2.77682799
65positive regulation of T cell mediated immunity (GO:0002711)2.77306988
66synaptic vesicle exocytosis (GO:0016079)2.77050181
67regulation of alpha-beta T cell activation (GO:0046634)2.76561514
68negative regulation of interleukin-12 production (GO:0032695)2.74901562
69alpha-beta T cell activation (GO:0046631)2.74744689
70regulation of T cell mediated immunity (GO:0002709)2.74517306
71regulation of memory T cell differentiation (GO:0043380)2.73957132
72hepatocyte apoptotic process (GO:0097284)2.73266851
73regulation of synaptic vesicle exocytosis (GO:2000300)2.73006840
74positive regulation of DNA recombination (GO:0045911)2.72371111
75regulation of exit from mitosis (GO:0007096)2.72355015
76positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.69309553
77negative regulation of B cell proliferation (GO:0030889)2.68769942
78negative regulation of adaptive immune response (GO:0002820)2.68260469
79regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.68108444
80positive regulation of isotype switching (GO:0045830)2.67679378
81detection of other organism (GO:0098543)2.67649556
82detection of bacterium (GO:0016045)2.66772762
83granulocyte activation (GO:0036230)2.66334075
84T cell differentiation (GO:0030217)2.65620051
85B cell receptor signaling pathway (GO:0050853)2.64973813
86regulation of B cell receptor signaling pathway (GO:0050855)2.64835009
87regulation of synaptic vesicle transport (GO:1902803)2.62899368
88positive regulation of gamma-delta T cell activation (GO:0046645)2.59538700
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57817192
90glycerophospholipid catabolic process (GO:0046475)2.57760762
91negative regulation of neurotransmitter secretion (GO:0046929)2.51758323
92regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48064690
93microtubule nucleation (GO:0007020)2.45707736
94synaptic vesicle maturation (GO:0016188)2.44065070
95regulation of isotype switching to IgG isotypes (GO:0048302)2.43035860
96monoubiquitinated protein deubiquitination (GO:0035520)2.39781421
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39654040
98negative regulation of meiosis (GO:0045835)2.38923689
99locomotory exploration behavior (GO:0035641)2.38636839
100mitotic chromosome condensation (GO:0007076)2.38466024
101regulation of defense response to virus by virus (GO:0050690)2.38112952
102mast cell degranulation (GO:0043303)2.37897074
103mast cell activation involved in immune response (GO:0002279)2.37897074
104mast cell activation (GO:0045576)2.37416240
105negative regulation of neurotransmitter transport (GO:0051589)2.37122036
106central nervous system myelination (GO:0022010)2.37034196
107axon ensheathment in central nervous system (GO:0032291)2.37034196
108nerve growth factor signaling pathway (GO:0038180)2.35343663
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.32655538
110regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31686070
111regulation of Rap GTPase activity (GO:0032317)2.31510962
112synaptic vesicle docking involved in exocytosis (GO:0016081)2.31483768
113negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.26282977
114regulation of ARF protein signal transduction (GO:0032012)2.25414022
115positive T cell selection (GO:0043368)2.24988803
116cellular response to interleukin-15 (GO:0071350)2.24139537
117regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.23628498
118leukocyte aggregation (GO:0070486)2.21131720
119T cell receptor signaling pathway (GO:0050852)2.19452752
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.19323952
121positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.18555881
122positive regulation of Rap GTPase activity (GO:0032854)2.16596273
123antigen receptor-mediated signaling pathway (GO:0050851)2.16300291
124Fc-gamma receptor signaling pathway (GO:0038094)2.16153558
125Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.16153558
126immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.16153558
127regulation of meiotic cell cycle (GO:0051445)2.15564131
128Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.15378723
129T cell migration (GO:0072678)2.14475398
130negative regulation of axonogenesis (GO:0050771)2.14374195
131vesicle transport along microtubule (GO:0047496)2.14166333
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.13535377
133glutamate secretion (GO:0014047)2.12186352
134long-term synaptic potentiation (GO:0060291)2.09611030
135T cell selection (GO:0045058)2.07839462
136NIK/NF-kappaB signaling (GO:0038061)2.07016278
137negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.06533142
138T cell costimulation (GO:0031295)2.06316089
139lymphocyte costimulation (GO:0031294)2.06024484
140immune response-activating cell surface receptor signaling pathway (GO:0002429)2.05577135
141positive regulation of granulocyte differentiation (GO:0030854)2.05172602
142female gamete generation (GO:0007292)2.04936868
143response to interleukin-15 (GO:0070672)2.04038122
144regulation of glutamate receptor signaling pathway (GO:1900449)2.03967339
145mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.03276120
146mitotic metaphase plate congression (GO:0007080)2.02870816
147regulation of actin nucleation (GO:0051125)2.02052846
148regulation of long-term neuronal synaptic plasticity (GO:0048169)2.02041219
149Rap protein signal transduction (GO:0032486)2.01506588
150layer formation in cerebral cortex (GO:0021819)2.01219997
151regulation of histone H3-K27 methylation (GO:0061085)2.00169417
152synaptic vesicle endocytosis (GO:0048488)1.98968038
153clathrin coat assembly (GO:0048268)1.98804547
154negative regulation of histone methylation (GO:0031061)1.98042406
155myelination (GO:0042552)1.97239586
156piRNA metabolic process (GO:0034587)1.96834577
157G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.96582748
158establishment of chromosome localization (GO:0051303)1.96581448
159regulation of establishment of cell polarity (GO:2000114)1.96328684
160axon ensheathment (GO:0008366)1.95891486
161ensheathment of neurons (GO:0007272)1.95891486
162microtubule severing (GO:0051013)1.95787309
163regulation of neuronal synaptic plasticity (GO:0048168)1.94698607
164positive regulation of oligodendrocyte differentiation (GO:0048714)1.94087652
165thymic T cell selection (GO:0045061)1.93046190
166signal complex assembly (GO:0007172)1.92657544
167negative regulation of phosphoprotein phosphatase activity (GO:0032515)1.91968296
168regulation of axon regeneration (GO:0048679)1.91714713
169regulation of neuron projection regeneration (GO:0070570)1.91714713
170positive thymic T cell selection (GO:0045059)1.91673032
171dendritic spine morphogenesis (GO:0060997)1.91387884
172barbed-end actin filament capping (GO:0051016)1.90876152
173regulation of sister chromatid cohesion (GO:0007063)1.90806866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.83244551
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74515406
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25051639
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06959421
5EZH2_22144423_ChIP-Seq_EOC_Human2.80684993
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.77077235
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.63718679
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55630460
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.29997509
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22405290
11GATA1_22025678_ChIP-Seq_K562_Human2.13980827
12GATA3_26560356_Chip-Seq_TH2_Human2.12650412
13MYB_26560356_Chip-Seq_TH1_Human2.06386456
14E2F7_22180533_ChIP-Seq_HELA_Human1.98631397
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.95047701
16SCL_19346495_ChIP-Seq_HPC-7_Human1.89680091
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88592854
18* RARB_27405468_Chip-Seq_BRAIN_Mouse1.80824625
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80483971
20RUNX_20019798_ChIP-Seq_JUKART_Human1.78446298
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70727742
22GBX2_23144817_ChIP-Seq_PC3_Human1.69064973
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65717961
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.64566840
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63633887
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62050813
27RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.55764321
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55525677
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55323387
30AR_21572438_ChIP-Seq_LNCaP_Human1.52172260
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52121410
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.48882701
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46492974
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46281953
35MYC_22102868_ChIP-Seq_BL_Human1.44043826
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41193801
37* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39980904
38* REST_21632747_ChIP-Seq_MESCs_Mouse1.39533209
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36986206
40IGF1R_20145208_ChIP-Seq_DFB_Human1.36372449
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35685689
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.35608058
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34220977
44* IRF8_27001747_Chip-Seq_BMDM_Mouse1.34085040
45MAF_26560356_Chip-Seq_TH1_Human1.34026639
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33500943
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32823146
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32547038
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32361126
50MYB_26560356_Chip-Seq_TH2_Human1.31740061
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31713070
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29079487
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27557440
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26767314
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.25748368
56VDR_24787735_ChIP-Seq_THP-1_Human1.25230841
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24399534
58SPI1_23127762_ChIP-Seq_K562_Human1.23969934
59* GATA3_27048872_Chip-Seq_THYMUS_Human1.22994267
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22369140
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.22190490
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21259152
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19159985
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19047353
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18653633
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.17486027
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16668522
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16318447
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.12948415
70* GATA3_26560356_Chip-Seq_TH1_Human1.12886009
71STAT3_23295773_ChIP-Seq_U87_Human1.12372133
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12315414
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.10650349
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.09589691
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09361818
76* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09183011
77TAF15_26573619_Chip-Seq_HEK293_Human1.09039149
78VDR_23849224_ChIP-Seq_CD4+_Human1.08426133
79* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05672317
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05549122
81RNF2_27304074_Chip-Seq_NSC_Mouse1.05271772
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05035173
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03850299
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03481724
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02727284
86* FUS_26573619_Chip-Seq_HEK293_Human1.02663253
87* SMRT_27268052_Chip-Seq_Bcells_Human1.02311765
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02126397
89SMAD4_21799915_ChIP-Seq_A2780_Human1.01688715
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01618944
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01217964
92* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00881763
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00853292
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99738706
95RNF2_27304074_Chip-Seq_ESCs_Mouse0.99252470
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99220430
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98645719
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98431345
99EWS_26573619_Chip-Seq_HEK293_Human0.97137716
100VDR_22108803_ChIP-Seq_LS180_Human0.96258069
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96052960
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95945380
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95327983
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95203387
105PU_27001747_Chip-Seq_BMDM_Mouse0.94277097
106* CRX_20693478_ChIP-Seq_RETINA_Mouse0.94103049
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94002408
108* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93758146
109ZNF274_21170338_ChIP-Seq_K562_Hela0.92362658
110BCAT_22108803_ChIP-Seq_LS180_Human0.91251378
111KDM2B_26808549_Chip-Seq_DND41_Human0.90917127
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90707941
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89845843
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89741215
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89700064
116P300_19829295_ChIP-Seq_ESCs_Human0.89277592
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.89247955
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88917588
119EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88877743
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.88831406
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88621073
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88451470
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88099263
124* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88063687
125DROSHA_22980978_ChIP-Seq_HELA_Human0.87989063
126* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87975016
127CIITA_25753668_ChIP-Seq_RAJI_Human0.87871168
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87640800
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.87488506
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87474679
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87398410
132ER_23166858_ChIP-Seq_MCF-7_Human0.87008692
133* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87001756
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86041511
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85780450
136P53_22387025_ChIP-Seq_ESCs_Mouse0.85574797
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85263505
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85025100
139TCF4_23295773_ChIP-Seq_U87_Human0.84917842
140SALL4_22934838_ChIP-ChIP_CD34+_Human0.84185877
141UTX_26944678_Chip-Seq_JUKART_Human0.83954637
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83809984
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82940374
144AR_25329375_ChIP-Seq_VCAP_Human0.82779483
145SPI1_23547873_ChIP-Seq_NB4_Human0.82667179
146MAF_26560356_Chip-Seq_TH2_Human0.82485268
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.82460824
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81676448
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81223680
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.80504709
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80370962
152KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80250455
153* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80185918
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79455910
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.79455910
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79052394
157SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78876534
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78864940
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78864940
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.78643431
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.78528369
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78439712
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78304203
164* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77823255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.19546938
2MP0003880_abnormal_central_pattern3.37860806
3MP0003724_increased_susceptibility_to3.16874091
4MP0003436_decreased_susceptibility_to2.61789889
5MP0004270_analgesia2.57719296
6MP0002166_altered_tumor_susceptibility2.47251610
7MP0003787_abnormal_imprinting2.45875664
8MP0005310_abnormal_salivary_gland2.41750166
9MP0005464_abnormal_platelet_physiology2.31120909
10MP0003635_abnormal_synaptic_transmissio2.29670266
11MP0001529_abnormal_vocalization2.11283393
12MP0005671_abnormal_response_to2.04378721
13MP0008877_abnormal_DNA_methylation2.01469062
14MP0010155_abnormal_intestine_physiology2.01289312
15MP0002653_abnormal_ependyma_morphology1.98440818
16MP0003763_abnormal_thymus_physiology1.96287491
17MP0004510_myositis1.90166612
18MP0002063_abnormal_learning/memory/cond1.89752485
19MP0002006_tumorigenesis1.79023276
20MP0000778_abnormal_nervous_system1.77833276
21MP0002064_seizures1.76755937
22MP0003303_peritoneal_inflammation1.76073378
23MP0001845_abnormal_inflammatory_respons1.75534357
24MP0009745_abnormal_behavioral_response1.69694863
25MP0005075_abnormal_melanosome_morpholog1.69329587
26MP0000920_abnormal_myelination1.68616545
27MP0001905_abnormal_dopamine_level1.63015121
28MP0002138_abnormal_hepatobiliary_system1.62160552
29MP0001835_abnormal_antigen_presentation1.59363915
30MP0003329_amyloid_beta_deposits1.58401642
31MP0000465_gastrointestinal_hemorrhage1.57364740
32MP0002102_abnormal_ear_morphology1.56847073
33MP0002572_abnormal_emotion/affect_behav1.55468501
34MP0001873_stomach_inflammation1.52092871
35MP0003183_abnormal_peptide_metabolism1.52037540
36MP0001800_abnormal_humoral_immune1.47866839
37MP0002420_abnormal_adaptive_immunity1.46822985
38MP0003300_gastrointestinal_ulcer1.46771999
39MP0001819_abnormal_immune_cell1.44685001
40MP0005000_abnormal_immune_tolerance1.44134649
41MP0002009_preneoplasia1.43451025
42MP0004947_skin_inflammation1.39948111
43MP0004381_abnormal_hair_follicle1.38753055
44MP0002398_abnormal_bone_marrow1.37327785
45MP0002452_abnormal_antigen_presenting1.36777250
46MP0002723_abnormal_immune_serum1.33462246
47MP0001486_abnormal_startle_reflex1.32561862
48MP0000569_abnormal_digit_pigmentation1.31420613
49MP0001790_abnormal_immune_system1.31234929
50MP0005387_immune_system_phenotype1.31234929
51MP0005379_endocrine/exocrine_gland_phen1.30045412
52MP0000685_abnormal_immune_system1.28209496
53MP0003077_abnormal_cell_cycle1.27439467
54MP0002693_abnormal_pancreas_physiology1.27015223
55MP0001533_abnormal_skeleton_physiology1.24778469
56MP0006082_CNS_inflammation1.24252506
57MP0009333_abnormal_splenocyte_physiolog1.22500468
58MP0000716_abnormal_immune_system1.21792954
59MP0002277_abnormal_respiratory_mucosa1.21315299
60MP0003172_abnormal_lysosome_physiology1.20018508
61MP0002272_abnormal_nervous_system1.19533004
62MP0004811_abnormal_neuron_physiology1.18576116
63MP0008469_abnormal_protein_level1.17798910
64MP0002734_abnormal_mechanical_nocicepti1.17695014
65MP0003634_abnormal_glial_cell1.16825371
66MP0002396_abnormal_hematopoietic_system1.16624340
67MP0005451_abnormal_body_composition1.16040052
68MP0003121_genomic_imprinting1.15826413
69MP0000703_abnormal_thymus_morphology1.12554506
70MP0000604_amyloidosis1.12462438
71MP0004924_abnormal_behavior1.12041084
72MP0005386_behavior/neurological_phenoty1.12041084
73MP0009764_decreased_sensitivity_to1.11204674
74MP0001968_abnormal_touch/_nociception1.08935052
75MP0000955_abnormal_spinal_cord1.05420633
76MP0002735_abnormal_chemical_nociception1.05261140
77MP0003632_abnormal_nervous_system1.02805657
78MP0001765_abnormal_ion_homeostasis1.02322883
79MP0003045_fibrosis1.02199423
80MP0002733_abnormal_thermal_nociception1.01879145
81MP0003195_calcinosis1.01347175
82MP0005645_abnormal_hypothalamus_physiol1.01326127
83MP0003252_abnormal_bile_duct1.00644449
84MP0001853_heart_inflammation1.00122674
85MP0001970_abnormal_pain_threshold1.00006330
86MP0004885_abnormal_endolymph0.98442194
87MP0008569_lethality_at_weaning0.98306593
88MP0001851_eye_inflammation0.97583038
89MP0002152_abnormal_brain_morphology0.96740584
90MP0001501_abnormal_sleep_pattern0.96401704
91MP0002184_abnormal_innervation0.95581076
92MP0009046_muscle_twitch0.95477917
93MP0002736_abnormal_nociception_after0.95380481
94MP0001986_abnormal_taste_sensitivity0.94605835
95MP0002882_abnormal_neuron_morphology0.94393692
96MP0000689_abnormal_spleen_morphology0.94235816
97MP0005423_abnormal_somatic_nervous0.94229301
98MP0004742_abnormal_vestibular_system0.91650424
99MP0002419_abnormal_innate_immunity0.91315360
100MP0002429_abnormal_blood_cell0.90564705
101MP0004858_abnormal_nervous_system0.90474213
102MP0001440_abnormal_grooming_behavior0.89221668
103MP0000631_abnormal_neuroendocrine_gland0.89075516
104MP0002067_abnormal_sensory_capabilities0.88756939
105MP0002722_abnormal_immune_system0.86526794
106MP0002148_abnormal_hypersensitivity_rea0.86050667
107MP0003861_abnormal_nervous_system0.85908745
108MP0010094_abnormal_chromosome_stability0.85036042
109MP0008872_abnormal_physiological_respon0.84659194
110MP0003879_abnormal_hair_cell0.84074567
111MP0005174_abnormal_tail_pigmentation0.83122392
112MP0002066_abnormal_motor_capabilities/c0.82571910
113MP0002876_abnormal_thyroid_physiology0.82529322
114MP0003866_abnormal_defecation0.81868703
115MP0002405_respiratory_system_inflammati0.81728734
116MP0003091_abnormal_cell_migration0.80300140
117MP0002557_abnormal_social/conspecific_i0.78899681
118MP0008007_abnormal_cellular_replicative0.78791330
119MP0005646_abnormal_pituitary_gland0.78296566
120MP0003690_abnormal_glial_cell0.77394013
121MP0008057_abnormal_DNA_replication0.77064421
122MP0002928_abnormal_bile_duct0.76983201
123MP0003631_nervous_system_phenotype0.76597143
124MP0004957_abnormal_blastocyst_morpholog0.76316191
125MP0002933_joint_inflammation0.75728754
126MP0010234_abnormal_vibrissa_follicle0.75171943
127MP0005084_abnormal_gallbladder_morpholo0.74948158
128MP0002163_abnormal_gland_morphology0.74796347
129MP0001485_abnormal_pinna_reflex0.74298115
130MP0001730_embryonic_growth_arrest0.74028367
131MP0003123_paternal_imprinting0.73154319
132MP0005025_abnormal_response_to0.72886298
133MP0001919_abnormal_reproductive_system0.72496845
134MP0009763_increased_sensitivity_to0.72314583
135MP0009780_abnormal_chondrocyte_physiolo0.71171031
136MP0000015_abnormal_ear_pigmentation0.70396665
137MP0009785_altered_susceptibility_to0.70117360
138MP0005166_decreased_susceptibility_to0.70042582
139MP0002132_abnormal_respiratory_system0.69785937
140MP0002822_catalepsy0.69670720
141MP0000350_abnormal_cell_proliferation0.69341317
142MP0001929_abnormal_gametogenesis0.67822283
143MP0002998_abnormal_bone_remodeling0.67468741
144MP0001663_abnormal_digestive_system0.65882564
145MP0004484_altered_response_of0.65599025
146MP0003656_abnormal_erythrocyte_physiolo0.64848856
147MP0009765_abnormal_xenobiotic_induced0.63639528
148MP0003075_altered_response_to0.63596174
149MP0002837_dystrophic_cardiac_calcinosis0.63520123
150MP0002136_abnormal_kidney_physiology0.62736838
151MP0004883_abnormal_blood_vessel0.61426031
152MP0002019_abnormal_tumor_incidence0.60269252
153MP0005535_abnormal_body_temperature0.59289278
154MP0005389_reproductive_system_phenotype0.59270174
155MP0003786_premature_aging0.57382860
156MP0010329_abnormal_lipoprotein_level0.56917570
157MP0000427_abnormal_hair_cycle0.56033535
158MP0005397_hematopoietic_system_phenotyp0.53624925
159MP0001545_abnormal_hematopoietic_system0.53624925
160MP0009643_abnormal_urine_homeostasis0.52802676
161MP0008995_early_reproductive_senescence0.52227266
162MP0004808_abnormal_hematopoietic_stem0.52211779
163MP0003448_altered_tumor_morphology0.51486546
164MP0005636_abnormal_mineral_homeostasis0.51172688

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)4.22764931
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.13745607
3Abnormality of T cells (HP:0002843)4.02079313
4Eczematoid dermatitis (HP:0000976)3.55364878
5Chronic diarrhea (HP:0002028)3.46438633
6Vasculitis (HP:0002633)3.31905836
7Chronic mucocutaneous candidiasis (HP:0002728)3.30627037
8Recurrent cutaneous fungal infections (HP:0011370)3.30627037
9Encephalitis (HP:0002383)3.28180614
10Abnormality of T cell physiology (HP:0011840)3.15477310
11Prolonged bleeding time (HP:0003010)3.12161006
12Gastrointestinal infarctions (HP:0005244)3.10935299
13Abnormality of the prostate (HP:0008775)3.08685548
14Focal motor seizures (HP:0011153)3.02902173
15Increased IgM level (HP:0003496)2.86940550
16Deep palmar crease (HP:0006191)2.83069460
17Atonic seizures (HP:0010819)2.81078527
18Recurrent skin infections (HP:0001581)2.80295099
19Hemoptysis (HP:0002105)2.79816939
20Pustule (HP:0200039)2.78798777
21Eosinophilia (HP:0001880)2.77612633
22Abnormality of macrophages (HP:0004311)2.76759939
23Stomach cancer (HP:0012126)2.76127704
24Papillary thyroid carcinoma (HP:0002895)2.75558438
25Chest pain (HP:0100749)2.74753366
26Neurofibrillary tangles (HP:0002185)2.74139461
27Petechiae (HP:0000967)2.69131600
28Granulocytopenia (HP:0001913)2.64011530
29Keratoconjunctivitis (HP:0001096)2.63921273
30Thyroiditis (HP:0100646)2.63621907
31Hematochezia (HP:0002573)2.62365744
32Keratoconjunctivitis sicca (HP:0001097)2.62270376
33Spontaneous hematomas (HP:0007420)2.59289759
34Supranuclear gaze palsy (HP:0000605)2.58353918
35Epistaxis (HP:0000421)2.57882884
36Gingival bleeding (HP:0000225)2.57672160
37Joint swelling (HP:0001386)2.56141218
38Chronic otitis media (HP:0000389)2.50809953
39Myokymia (HP:0002411)2.50203527
40Recurrent abscess formation (HP:0002722)2.47066436
41Arterial thrombosis (HP:0004420)2.46521819
42Apathy (HP:0000741)2.45554417
43Pulmonary embolism (HP:0002204)2.44879552
44Progressive inability to walk (HP:0002505)2.41129403
45Cerebral inclusion bodies (HP:0100314)2.41117258
46Thickened helices (HP:0000391)2.37336830
47T lymphocytopenia (HP:0005403)2.34795576
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.34650121
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34650121
50Diminished motivation (HP:0000745)2.31493625
51Male infertility (HP:0003251)2.31296798
52Hypoproteinemia (HP:0003075)2.28104553
53Inflammation of the large intestine (HP:0002037)2.27838306
54Disinhibition (HP:0000734)2.27585158
55Amyotrophic lateral sclerosis (HP:0007354)2.27482043
56Severe combined immunodeficiency (HP:0004430)2.27338744
57Neoplasm of the tracheobronchial system (HP:0100552)2.26446641
58Mutism (HP:0002300)2.23404982
59Alveolar cell carcinoma (HP:0006519)2.22430648
60Abnormality of T cell number (HP:0011839)2.21207174
61Gangrene (HP:0100758)2.21109719
62Combined immunodeficiency (HP:0005387)2.19812549
63Inappropriate behavior (HP:0000719)2.16523950
64Abnormality of the pleura (HP:0002103)2.13751414
65Papilledema (HP:0001085)2.13743957
66Myositis (HP:0100614)2.10915656
67Spastic gait (HP:0002064)2.10398058
68Peripheral hypomyelination (HP:0007182)2.09796977
69Retrobulbar optic neuritis (HP:0100654)2.08281824
70Optic neuritis (HP:0100653)2.08281824
71Anorexia (HP:0002039)2.08074427
72Recurrent viral infections (HP:0004429)2.06953816
73Abnormality of B cell number (HP:0010975)2.04282271
74B lymphocytopenia (HP:0010976)2.04282271
75Gastrointestinal inflammation (HP:0004386)2.04008551
76Agnosia (HP:0010524)2.02630539
77Papilloma (HP:0012740)2.02527791
78Verrucae (HP:0200043)2.02527791
79Insidious onset (HP:0003587)2.00489393
80Termporal pattern (HP:0011008)2.00489393
81Episodic fever (HP:0001954)1.99621942
82Visual hallucinations (HP:0002367)1.99610040
83Abnormality of liposaccharide metabolism (HP:0010968)1.99318896
84Abnormality of glycosphingolipid metabolism (HP:0004343)1.99318896
85Abnormality of glycolipid metabolism (HP:0010969)1.99318896
86Agammaglobulinemia (HP:0004432)1.98182879
87Birth length less than 3rd percentile (HP:0003561)1.96701847
88Urticaria (HP:0001025)1.95706253
89Cerebral hypomyelination (HP:0006808)1.95579927
90Hypergammaglobulinemia (HP:0010702)1.95479469
91Recurrent bacterial skin infections (HP:0005406)1.94991366
92Polyneuropathy (HP:0001271)1.94276666
93Autoimmune thrombocytopenia (HP:0001973)1.93282222
94Fatigue (HP:0012378)1.93102326
95Acute hepatic failure (HP:0006554)1.93093701
96Prostate neoplasm (HP:0100787)1.93066735
97Ankle clonus (HP:0011448)1.93054599
98Abnormality of chromosome segregation (HP:0002916)1.92789364
99Epileptic encephalopathy (HP:0200134)1.89736778
100Lymphoma (HP:0002665)1.89173566
101Akinesia (HP:0002304)1.89133185
102Abnormality of the corticospinal tract (HP:0002492)1.88601803
103Cellulitis (HP:0100658)1.85574999
104Recurrent bronchitis (HP:0002837)1.85567580
105Hypoplasia of the thymus (HP:0000778)1.84940949
106Abnormality of the renal cortex (HP:0011035)1.82246483
107Recurrent sinusitis (HP:0011108)1.81732811
108Focal seizures (HP:0007359)1.81572236
109Abnormality of the labia minora (HP:0012880)1.80789041
110Panhypogammaglobulinemia (HP:0003139)1.80270369
111Mediastinal lymphadenopathy (HP:0100721)1.80251062
112Sensory axonal neuropathy (HP:0003390)1.79883279
113Chronic obstructive pulmonary disease (HP:0006510)1.78918338
114Obstructive lung disease (HP:0006536)1.78918338
115Dysmetria (HP:0001310)1.78747554
116Drooling (HP:0002307)1.78532154
117Excessive salivation (HP:0003781)1.78532154
118Congenital stationary night blindness (HP:0007642)1.78122880
119Widely spaced teeth (HP:0000687)1.77305298
120Abnormality of male internal genitalia (HP:0000022)1.76185377
121Hypothermia (HP:0002045)1.75218022
122Facial hemangioma (HP:0000329)1.75025361
123Fetal akinesia sequence (HP:0001989)1.74684759
124Arterial tortuosity (HP:0005116)1.73404184
125Thyroid carcinoma (HP:0002890)1.72787860
126Abnormality of eosinophils (HP:0001879)1.72479027
127Abnormality of the fingertips (HP:0001211)1.72280642
128Lymphopenia (HP:0001888)1.71626244
129Recurrent fungal infections (HP:0002841)1.71367996
130Increased CSF protein (HP:0002922)1.71298903
131Recurrent gram-negative bacterial infections (HP:0005420)1.70823479
132Keratitis (HP:0000491)1.70508978
133Skin rash (HP:0000988)1.70188068
134Truncal ataxia (HP:0002078)1.70087043
135Stomatitis (HP:0010280)1.70066108
136Abnormality of vitamin B metabolism (HP:0004340)1.69670643
137Stereotypic behavior (HP:0000733)1.69591397
138Renal cortical cysts (HP:0000803)1.69296757
139Amaurosis fugax (HP:0100576)1.68941057
140Orchitis (HP:0100796)1.68280350
141Chronic sinusitis (HP:0011109)1.67169164
142Pulmonary fibrosis (HP:0002206)1.65562580
143Megalencephaly (HP:0001355)1.65547347
144Leukocytosis (HP:0001974)1.65008885
145Bronchitis (HP:0012387)1.64883105
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.64474383
147IgA deficiency (HP:0002720)1.64316553
148Gait imbalance (HP:0002141)1.62801297
149Elevated erythrocyte sedimentation rate (HP:0003565)1.61559320
150IgM deficiency (HP:0002850)1.61530040
151Meningitis (HP:0001287)1.60971223
152Heterochromia iridis (HP:0001100)1.60601365
153IgG deficiency (HP:0004315)1.58292710
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.57439752
155Postnatal microcephaly (HP:0005484)1.56045313
156CNS hypomyelination (HP:0003429)1.55906776
157Urinary bladder sphincter dysfunction (HP:0002839)1.55540344
158Broad-based gait (HP:0002136)1.55447986
159Pulmonary infiltrates (HP:0002113)1.55312362
160Diplopia (HP:0000651)1.55194689
161Abnormality of binocular vision (HP:0011514)1.55194689
162Abnormal hair whorl (HP:0010721)1.55138173
163Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.54643109
164Esophageal atresia (HP:0002032)1.53516574
165Long palpebral fissure (HP:0000637)1.51521907
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48343663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.91687902
2FRK3.89734824
3KSR23.62005643
4MAP3K133.46343224
5KSR12.91868432
6ARAF2.80666767
7RAF12.51826293
8PAK62.36672683
9TEC2.25320087
10EPHA42.11890605
11BTK2.08395717
12BMPR21.98897584
13TYRO31.97496591
14MAP3K41.95700205
15MAP4K11.95199457
16MAP3K141.95126785
17TYK21.86088399
18MOS1.81428527
19BRAF1.79459616
20PRPF4B1.79011408
21RIPK41.72996378
22MAP3K61.72954771
23LATS21.70712156
24LATS11.67214035
25ZAP701.66475658
26TAOK11.62159899
27CSK1.61591898
28FGFR31.58880539
29CAMKK21.58839674
30MARK11.55436395
31IKBKB1.52902598
32STK101.52425097
33IRAK41.51492495
34BLK1.50949776
35NLK1.49639470
36TNK21.47392634
37CDK191.42874595
38MAP3K121.42463009
39LYN1.40677543
40FES1.36037139
41PLK21.35513876
42NTRK31.34564045
43PLK41.32304284
44FGR1.30762094
45MAP2K71.29182495
46MAPK131.26024363
47TXK1.25634283
48MELK1.25526665
49ADRBK21.24009271
50ERBB41.22342719
51DYRK21.17283079
52FGFR21.12605417
53CDC71.11468755
54BCR1.10881205
55NTRK21.10784428
56TBK11.06734320
57NUAK11.04849982
58MINK11.02016717
59TNIK0.99213389
60PIK3CG0.96902999
61BMPR1B0.96063214
62IRAK10.95326139
63OXSR10.95051346
64GRK60.94803602
65JAK20.94643986
66CSNK1G20.92151080
67EEF2K0.91720560
68SIK30.88642717
69JAK30.88204860
70MARK20.87872915
71GRK10.84382244
72ITK0.84066777
73TAOK30.83753831
74DAPK10.83680799
75CDK50.83585921
76GRK70.83027343
77CSNK1G30.82258049
78PRKCH0.81812625
79PRKCQ0.79770993
80RET0.77991076
81PRKD30.77405554
82TESK20.76633462
83EIF2AK30.76279145
84GRK50.76244065
85ERBB30.74962000
86MST40.73709451
87PIM10.73044301
88BRSK10.72306956
89CDK180.71464210
90MAP2K60.70593619
91CASK0.70472741
92PTK2B0.70352603
93TRPM70.69883718
94STK240.69207558
95UHMK10.69040613
96ROCK20.67827344
97CDK150.65991676
98SYK0.64675169
99HIPK20.64669252
100CCNB10.63884625
101CDK80.63597052
102CSNK1A1L0.62374951
103CDK140.62230975
104SIK20.61936964
105MAP3K20.61112570
106MAP4K20.60688352
107LCK0.60465613
108NTRK10.60065971
109CDK11A0.59267868
110PASK0.56044125
111EPHA30.55389481
112YES10.55092902
113PDK10.53754832
114PDGFRB0.53455460
115TRIM280.53414603
116MAPK110.52893898
117MUSK0.51180027
118DMPK0.51176834
119IGF1R0.50484291
120PAK30.50382331
121PIK3CA0.50268280
122CHEK20.50225889
123EPHB10.50215425
124MAP2K20.50181408
125MARK30.49985019
126CDK90.49967860
127CSNK1G10.48805902
128CAMK2B0.48765366
129HCK0.48151242
130FYN0.47951567
131PKN10.47763629
132SGK4940.47572901
133SGK2230.47572901
134KIT0.47452474
135CLK10.47414207
136IKBKE0.47157866
137SGK20.46318426
138CSF1R0.45952168
139CHUK0.45591253
140MAP3K10.45339955
141BUB10.44514866
142CAMKK10.44380374
143STK110.44280858
144STK390.44254259
145PINK10.43319510
146EGFR0.42960638
147DAPK20.42245948
148JAK10.41556775
149ACVR1B0.41017230
150ABL10.38615393
151MATK0.38097193
152TLK10.37963746
153FGFR40.35299895
154EIF2AK10.33461866
155SGK30.29109558
156MAPK70.28650560
157MAPKAPK30.28300515
158INSRR0.27628044
159IRAK20.25910802
160MAP2K30.25542836
161KDR0.24882716
162NEK60.23745944

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.78619226
2Allograft rejection_Homo sapiens_hsa053303.69445891
3Autoimmune thyroid disease_Homo sapiens_hsa053203.63155955
4Asthma_Homo sapiens_hsa053102.67230639
5Staphylococcus aureus infection_Homo sapiens_hsa051501.90442359
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71436033
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66202754
8T cell receptor signaling pathway_Homo sapiens_hsa046601.63177923
9Long-term potentiation_Homo sapiens_hsa047201.51052957
10B cell receptor signaling pathway_Homo sapiens_hsa046621.46137870
11Primary immunodeficiency_Homo sapiens_hsa053401.45438429
12Herpes simplex infection_Homo sapiens_hsa051681.43942419
13Synaptic vesicle cycle_Homo sapiens_hsa047211.42262401
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42039482
15Pancreatic cancer_Homo sapiens_hsa052121.40676368
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40327957
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40151893
18Renal cell carcinoma_Homo sapiens_hsa052111.39201939
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37110408
20Colorectal cancer_Homo sapiens_hsa052101.31718030
21Long-term depression_Homo sapiens_hsa047301.27231790
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.26816240
23Olfactory transduction_Homo sapiens_hsa047401.25898297
24Chemokine signaling pathway_Homo sapiens_hsa040621.23739598
25Glutamatergic synapse_Homo sapiens_hsa047241.23615159
26VEGF signaling pathway_Homo sapiens_hsa043701.23151658
27Shigellosis_Homo sapiens_hsa051311.22581535
28Oocyte meiosis_Homo sapiens_hsa041141.21172198
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20864646
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18870648
31Morphine addiction_Homo sapiens_hsa050321.16918544
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15737797
33Influenza A_Homo sapiens_hsa051641.15263529
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13253165
35Dopaminergic synapse_Homo sapiens_hsa047281.12254854
36ErbB signaling pathway_Homo sapiens_hsa040121.12159342
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.07886880
38Circadian entrainment_Homo sapiens_hsa047131.07069967
39Axon guidance_Homo sapiens_hsa043601.06716619
40Cholinergic synapse_Homo sapiens_hsa047251.06507984
41GnRH signaling pathway_Homo sapiens_hsa049121.06123475
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05487322
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05363266
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.04913488
45Osteoclast differentiation_Homo sapiens_hsa043801.04581186
46Nicotine addiction_Homo sapiens_hsa050331.04236535
47Legionellosis_Homo sapiens_hsa051341.02700822
48Serotonergic synapse_Homo sapiens_hsa047261.00995491
49Dorso-ventral axis formation_Homo sapiens_hsa043201.00084212
50Collecting duct acid secretion_Homo sapiens_hsa049660.99812661
51Glioma_Homo sapiens_hsa052140.98702437
52Choline metabolism in cancer_Homo sapiens_hsa052310.98129212
53Vibrio cholerae infection_Homo sapiens_hsa051100.97978261
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97242256
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97026267
56Prolactin signaling pathway_Homo sapiens_hsa049170.96550625
57Non-small cell lung cancer_Homo sapiens_hsa052230.96197926
58Cell cycle_Homo sapiens_hsa041100.96193956
59Endocytosis_Homo sapiens_hsa041440.95332016
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94178944
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.93243444
62Oxytocin signaling pathway_Homo sapiens_hsa049210.93021552
63Endometrial cancer_Homo sapiens_hsa052130.90945942
64Amphetamine addiction_Homo sapiens_hsa050310.90405821
65Leishmaniasis_Homo sapiens_hsa051400.89907032
66Regulation of autophagy_Homo sapiens_hsa041400.87490638
67GABAergic synapse_Homo sapiens_hsa047270.86692084
68MAPK signaling pathway_Homo sapiens_hsa040100.86091970
69Estrogen signaling pathway_Homo sapiens_hsa049150.84513625
70Ether lipid metabolism_Homo sapiens_hsa005650.84159349
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84058754
72Ras signaling pathway_Homo sapiens_hsa040140.83803373
73Rheumatoid arthritis_Homo sapiens_hsa053230.83712750
74Tuberculosis_Homo sapiens_hsa051520.83104538
75Chronic myeloid leukemia_Homo sapiens_hsa052200.82883394
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81945588
77Hepatitis B_Homo sapiens_hsa051610.80798514
78Measles_Homo sapiens_hsa051620.77741175
79Salmonella infection_Homo sapiens_hsa051320.77610148
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73616720
81Gap junction_Homo sapiens_hsa045400.72652713
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71596820
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.70645779
84Cocaine addiction_Homo sapiens_hsa050300.70590349
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70364297
86Basal transcription factors_Homo sapiens_hsa030220.70036284
87Type I diabetes mellitus_Homo sapiens_hsa049400.70029850
88Platelet activation_Homo sapiens_hsa046110.69678711
89MicroRNAs in cancer_Homo sapiens_hsa052060.69128593
90Gastric acid secretion_Homo sapiens_hsa049710.69110844
91Hepatitis C_Homo sapiens_hsa051600.68780233
92RNA degradation_Homo sapiens_hsa030180.68592347
93Salivary secretion_Homo sapiens_hsa049700.68108870
94Linoleic acid metabolism_Homo sapiens_hsa005910.67925667
95cAMP signaling pathway_Homo sapiens_hsa040240.67617644
96Toxoplasmosis_Homo sapiens_hsa051450.67082488
97Inositol phosphate metabolism_Homo sapiens_hsa005620.67012043
98Ovarian steroidogenesis_Homo sapiens_hsa049130.66892005
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66849593
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66275061
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64888811
102Antigen processing and presentation_Homo sapiens_hsa046120.63453543
103Renin secretion_Homo sapiens_hsa049240.62543024
104Caffeine metabolism_Homo sapiens_hsa002320.62289238
105Epstein-Barr virus infection_Homo sapiens_hsa051690.62125442
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61954524
107Viral myocarditis_Homo sapiens_hsa054160.61028793
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61012582
109Phagosome_Homo sapiens_hsa041450.60738935
110mTOR signaling pathway_Homo sapiens_hsa041500.60728032
111Malaria_Homo sapiens_hsa051440.60573129
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.60352795
113Lysosome_Homo sapiens_hsa041420.59889132
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.59376191
115Type II diabetes mellitus_Homo sapiens_hsa049300.59320473
116Rap1 signaling pathway_Homo sapiens_hsa040150.59150539
117Acute myeloid leukemia_Homo sapiens_hsa052210.58792389
118African trypanosomiasis_Homo sapiens_hsa051430.58766583
119Nitrogen metabolism_Homo sapiens_hsa009100.57395425
120TNF signaling pathway_Homo sapiens_hsa046680.56651729
121Insulin secretion_Homo sapiens_hsa049110.56066393
122Circadian rhythm_Homo sapiens_hsa047100.56001894
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55914597
124Hematopoietic cell lineage_Homo sapiens_hsa046400.55697414
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.55517908
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54182682
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52559003
128Apoptosis_Homo sapiens_hsa042100.51906347
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50510883
130Pertussis_Homo sapiens_hsa051330.46110296
131Phototransduction_Homo sapiens_hsa047440.44168485
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41783542
133Arachidonic acid metabolism_Homo sapiens_hsa005900.41516735
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37989777
135FoxO signaling pathway_Homo sapiens_hsa040680.37900145
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37702554
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36814440
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.36628596
139Viral carcinogenesis_Homo sapiens_hsa052030.35972854
140Systemic lupus erythematosus_Homo sapiens_hsa053220.33701787
141Sulfur metabolism_Homo sapiens_hsa009200.33044903
142HTLV-I infection_Homo sapiens_hsa051660.32725364
143ABC transporters_Homo sapiens_hsa020100.28556603
144Insulin resistance_Homo sapiens_hsa049310.27924891
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27255973
146Pancreatic secretion_Homo sapiens_hsa049720.23603370
147Glycerolipid metabolism_Homo sapiens_hsa005610.22578867
148Peroxisome_Homo sapiens_hsa041460.21314357

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