CDC5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replicative senescence (GO:0090399)5.48480063
2regulation of DNA endoreduplication (GO:0032875)5.22539237
3regulation of somitogenesis (GO:0014807)4.98027356
4DNA integration (GO:0015074)4.74409768
5mitotic metaphase plate congression (GO:0007080)4.56141754
6viral mRNA export from host cell nucleus (GO:0046784)4.43345119
7nucleobase biosynthetic process (GO:0046112)4.33532417
8purine nucleobase biosynthetic process (GO:0009113)4.30279751
9maturation of SSU-rRNA (GO:0030490)4.29255981
10DNA replication checkpoint (GO:0000076)4.26356881
11DNA replication initiation (GO:0006270)4.21692911
12prenylation (GO:0097354)4.21440811
13protein prenylation (GO:0018342)4.21440811
14nuclear pore organization (GO:0006999)4.17942826
15ribosome assembly (GO:0042255)4.15829681
16formation of translation preinitiation complex (GO:0001731)4.15816619
17DNA strand elongation involved in DNA replication (GO:0006271)4.12051079
18protein localization to kinetochore (GO:0034501)4.06504327
19nuclear pore complex assembly (GO:0051292)3.94280899
20metaphase plate congression (GO:0051310)3.94099236
21hematopoietic stem cell proliferation (GO:0071425)3.91175615
22DNA strand elongation (GO:0022616)3.90466128
23DNA replication-dependent nucleosome organization (GO:0034723)3.89164326
24DNA replication-dependent nucleosome assembly (GO:0006335)3.89164326
25mitotic nuclear envelope disassembly (GO:0007077)3.85254405
26DNA unwinding involved in DNA replication (GO:0006268)3.84103471
27kinetochore organization (GO:0051383)3.79853578
28telomere maintenance via semi-conservative replication (GO:0032201)3.78184438
29regulation of centriole replication (GO:0046599)3.77810924
30positive regulation of prostaglandin secretion (GO:0032308)3.71098985
31ribosome biogenesis (GO:0042254)3.70179864
32chromatin remodeling at centromere (GO:0031055)3.65381860
33telomere maintenance via recombination (GO:0000722)3.58361372
34IMP biosynthetic process (GO:0006188)3.58246994
35regulation of spindle organization (GO:0090224)3.57201031
36regulation of helicase activity (GO:0051095)3.56684767
37CENP-A containing nucleosome assembly (GO:0034080)3.56601961
38membrane disassembly (GO:0030397)3.56390920
39nuclear envelope disassembly (GO:0051081)3.56390920
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55325220
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.55325220
42NADH dehydrogenase complex assembly (GO:0010257)3.55325220
43mitotic recombination (GO:0006312)3.52640478
44DNA double-strand break processing (GO:0000729)3.52398695
45positive regulation of chromosome segregation (GO:0051984)3.51842422
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51442775
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.51442775
48kinetochore assembly (GO:0051382)3.49816566
49ribonucleoprotein complex biogenesis (GO:0022613)3.48474912
50protein localization to chromosome, centromeric region (GO:0071459)3.46916347
51establishment of chromosome localization (GO:0051303)3.46471251
52regulation of prostaglandin secretion (GO:0032306)3.45896855
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44557163
54ribosomal large subunit biogenesis (GO:0042273)3.44428302
55DNA replication-independent nucleosome organization (GO:0034724)3.43967560
56DNA replication-independent nucleosome assembly (GO:0006336)3.43967560
57mitotic chromosome condensation (GO:0007076)3.42520479
58replication fork processing (GO:0031297)3.41831758
59mitotic sister chromatid segregation (GO:0000070)3.41130897
60ribosomal small subunit assembly (GO:0000028)3.39955505
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39237967
62mitotic sister chromatid cohesion (GO:0007064)3.38538473
63rRNA processing (GO:0006364)3.34191983
64attachment of spindle microtubules to kinetochore (GO:0008608)3.33616229
65regulation of DNA damage checkpoint (GO:2000001)3.33407853
66folic acid-containing compound biosynthetic process (GO:0009396)3.30900696
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.28850861
68telomere maintenance via telomere lengthening (GO:0010833)3.27450899
69rRNA metabolic process (GO:0016072)3.25541343
70protein K6-linked ubiquitination (GO:0085020)3.22372408
71telomere maintenance (GO:0000723)3.21807029
72telomere organization (GO:0032200)3.21101599
73histone exchange (GO:0043486)3.20854385
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.20147178
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.18918098
76pore complex assembly (GO:0046931)3.17533540
77spliceosomal snRNP assembly (GO:0000387)3.17407010
78maturation of 5.8S rRNA (GO:0000460)3.17272641
79regulation of histone H3-K9 methylation (GO:0051570)3.15940901
80transcription-coupled nucleotide-excision repair (GO:0006283)3.14735333
81spindle checkpoint (GO:0031577)3.14178948
82IMP metabolic process (GO:0046040)3.11993528
83regulation of chromosome segregation (GO:0051983)3.11826761
84sister chromatid segregation (GO:0000819)3.11644281
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11382591
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11368582
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.11368582
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11368582
89meiotic chromosome segregation (GO:0045132)3.10654624
90ribosomal small subunit biogenesis (GO:0042274)3.10116209
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.09943746
92rRNA modification (GO:0000154)3.09062124
93negative regulation of histone methylation (GO:0031061)3.08267370
94regulation of mitotic spindle organization (GO:0060236)3.08073215
95regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.06922751
96negative regulation of chromosome segregation (GO:0051985)3.06194206
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05434464
98regulation of centrosome cycle (GO:0046605)3.05202389
99translational initiation (GO:0006413)3.03874577
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03752290
101synapsis (GO:0007129)3.03400484
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02918438
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.02408880
104negative regulation of sister chromatid segregation (GO:0033046)3.01403637
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.01403637
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01403637
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01403637
108DNA geometric change (GO:0032392)3.01330470
109mitotic spindle checkpoint (GO:0071174)3.01036953
110regulation of posttranscriptional gene silencing (GO:0060147)3.00814708
111regulation of gene silencing by miRNA (GO:0060964)3.00814708
112regulation of gene silencing by RNA (GO:0060966)3.00814708
113DNA duplex unwinding (GO:0032508)3.00577335
114spindle assembly checkpoint (GO:0071173)2.99995693
115proteasome assembly (GO:0043248)2.98881994
116mitochondrial respiratory chain complex assembly (GO:0033108)2.97703764
117mitotic spindle assembly checkpoint (GO:0007094)2.97688807
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97611115
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96036719
120termination of RNA polymerase I transcription (GO:0006363)2.93543370
121transcription elongation from RNA polymerase I promoter (GO:0006362)2.91492325
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91397857
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91177714
124translational termination (GO:0006415)2.90770902
125monoubiquitinated protein deubiquitination (GO:0035520)2.90719024
126G1/S transition of mitotic cell cycle (GO:0000082)2.90298673
127regulation of mitotic sister chromatid separation (GO:0010965)2.89990525
128regulation of mitotic sister chromatid segregation (GO:0033047)2.89990525
129regulation of sister chromatid segregation (GO:0033045)2.89990525
130non-recombinational repair (GO:0000726)2.88599002
131double-strand break repair via nonhomologous end joining (GO:0006303)2.88599002
132regulation of cell cycle G2/M phase transition (GO:1902749)2.84322941
133protein complex biogenesis (GO:0070271)2.83870101
134chromatin assembly or disassembly (GO:0006333)2.83682442
135double-strand break repair via homologous recombination (GO:0000724)2.83147096
136recombinational repair (GO:0000725)2.81287554
137regulation of centrosome duplication (GO:0010824)2.80291256
138sister chromatid cohesion (GO:0007062)2.78789590
139resolution of meiotic recombination intermediates (GO:0000712)2.77611073
140histone-serine phosphorylation (GO:0035404)2.75021623
141somatic recombination of immunoglobulin gene segments (GO:0016447)2.74659022
142somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72959235
143isotype switching (GO:0045190)2.72959235
144somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72959235
145translesion synthesis (GO:0019985)2.69542374
146spindle assembly involved in mitosis (GO:0090307)2.67765632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55856883
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17198822
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04665318
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64534600
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48753562
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13200623
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11675232
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09122056
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08664751
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.03053073
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97100699
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.86979432
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85608220
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.84527967
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76552459
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64843339
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63411444
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53365732
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46374625
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40968915
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38413033
22* VDR_23849224_ChIP-Seq_CD4+_Human2.30313870
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22282130
24XRN2_22483619_ChIP-Seq_HELA_Human2.20783844
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18154801
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12129929
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08914689
28AR_21909140_ChIP-Seq_LNCAP_Human2.02968017
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99737422
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98923940
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.97588953
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95118327
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94259609
34* E2F1_21310950_ChIP-Seq_MCF-7_Human1.92834820
35FOXP3_21729870_ChIP-Seq_TREG_Human1.92607128
36EWS_26573619_Chip-Seq_HEK293_Human1.87309177
37* FUS_26573619_Chip-Seq_HEK293_Human1.86459232
38DCP1A_22483619_ChIP-Seq_HELA_Human1.85446515
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79634942
40TTF2_22483619_ChIP-Seq_HELA_Human1.77280807
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77178731
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76590276
43GABP_19822575_ChIP-Seq_HepG2_Human1.76453287
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76202599
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74225965
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72688811
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.71993719
48ELK1_19687146_ChIP-ChIP_HELA_Human1.70366871
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67484944
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64483326
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63502416
52IRF1_19129219_ChIP-ChIP_H3396_Human1.61661652
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59767234
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59767234
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59767234
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58534008
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58114582
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56873255
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.56610437
60ZNF274_21170338_ChIP-Seq_K562_Hela1.54442438
61CIITA_25753668_ChIP-Seq_RAJI_Human1.52422493
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52390053
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50696246
64KDM5A_27292631_Chip-Seq_BREAST_Human1.45353104
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45252664
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45029108
67* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43612510
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42573053
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41762972
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40024055
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37443807
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36368852
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34454352
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30747229
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.29574896
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.28946947
77TAF15_26573619_Chip-Seq_HEK293_Human1.28569370
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26367511
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.24335241
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22148510
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21932266
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.21789443
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18996755
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17155664
85GBX2_23144817_ChIP-Seq_PC3_Human1.16525279
86IGF1R_20145208_ChIP-Seq_DFB_Human1.16372926
87* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15500609
88TFEB_21752829_ChIP-Seq_HELA_Human1.14388514
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14117588
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12584289
91MYC_22102868_ChIP-Seq_BL_Human1.12579811
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11692151
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11559353
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11149064
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10955862
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10138908
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.07410420
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06510558
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06319017
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05788484
101TP53_16413492_ChIP-PET_HCT116_Human1.05595225
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05120423
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04639142
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03882122
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03563356
106P300_19829295_ChIP-Seq_ESCs_Human1.01918704
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01366024
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00540425
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00100871
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99547302
111* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98958718
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98363642
113TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97908031
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97301375
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94852847
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94097000
117CBP_20019798_ChIP-Seq_JUKART_Human0.93792101
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93792101
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.93316426
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.92514876
121ER_23166858_ChIP-Seq_MCF-7_Human0.91659436
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90957609
123* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89601683
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89361048
125VDR_22108803_ChIP-Seq_LS180_Human0.89249565
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.88543908
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88013532
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87918549
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87590168
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87558479
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87443171
132MYC_18940864_ChIP-ChIP_HL60_Human0.86046255
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.85959959
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85650012
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84566259
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84170654
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83608655
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82693475
139SOX9_26525672_Chip-Seq_HEART_Mouse0.81443420
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80741056
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74646701
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.73354467
143PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71157061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.70552747
2MP0010094_abnormal_chromosome_stability4.85231710
3MP0008057_abnormal_DNA_replication4.82666535
4MP0003111_abnormal_nucleus_morphology4.80063732
5MP0004957_abnormal_blastocyst_morpholog4.70678079
6MP0003077_abnormal_cell_cycle4.15254659
7MP0008058_abnormal_DNA_repair3.66741892
8MP0008007_abnormal_cellular_replicative2.84660663
9MP0008877_abnormal_DNA_methylation2.76721187
10MP0008932_abnormal_embryonic_tissue2.73489706
11MP0003123_paternal_imprinting2.70580113
12MP0001730_embryonic_growth_arrest2.63727587
13MP0000350_abnormal_cell_proliferation2.44055680
14MP0009697_abnormal_copulation2.41038336
15MP0003786_premature_aging2.29971668
16MP0000569_abnormal_digit_pigmentation2.28164225
17MP0010352_gastrointestinal_tract_polyps2.21969583
18MP0010307_abnormal_tumor_latency2.21851146
19MP0001697_abnormal_embryo_size1.90302339
20MP0001672_abnormal_embryogenesis/_devel1.89744069
21MP0005380_embryogenesis_phenotype1.89744069
22MP0003718_maternal_effect1.87492711
23MP0002085_abnormal_embryonic_tissue1.74551880
24MP0002084_abnormal_developmental_patter1.72278495
25MP0002396_abnormal_hematopoietic_system1.70784155
26MP0002080_prenatal_lethality1.69065362
27MP0003984_embryonic_growth_retardation1.67004317
28MP0002088_abnormal_embryonic_growth/wei1.63849773
29MP0000372_irregular_coat_pigmentation1.58173174
30MP0002086_abnormal_extraembryonic_tissu1.54478833
31MP0004197_abnormal_fetal_growth/weight/1.53163130
32MP0003121_genomic_imprinting1.53102263
33MP0002009_preneoplasia1.49345338
34MP0003567_abnormal_fetal_cardiomyocyte1.48295441
35MP0000313_abnormal_cell_death1.46326178
36MP0002210_abnormal_sex_determination1.45410868
37MP0000490_abnormal_crypts_of1.44250092
38MP0002102_abnormal_ear_morphology1.41658907
39MP0003806_abnormal_nucleotide_metabolis1.41282745
40MP0003890_abnormal_embryonic-extraembry1.37548634
41MP0008872_abnormal_physiological_respon1.36497642
42MP0001145_abnormal_male_reproductive1.31990637
43MP0003315_abnormal_perineum_morphology1.31746929
44MP0000631_abnormal_neuroendocrine_gland1.30453284
45MP0001293_anophthalmia1.27033472
46MP0002019_abnormal_tumor_incidence1.26723037
47MP0003941_abnormal_skin_development1.23356009
48MP0005076_abnormal_cell_differentiation1.20034427
49MP0005083_abnormal_biliary_tract1.18323419
50MP0001929_abnormal_gametogenesis1.18046534
51MP0004808_abnormal_hematopoietic_stem1.17961072
52MP0002653_abnormal_ependyma_morphology1.16369487
53MP0002163_abnormal_gland_morphology1.14213194
54MP0006292_abnormal_olfactory_placode1.12897481
55MP0003119_abnormal_digestive_system1.11791648
56MP0005084_abnormal_gallbladder_morpholo1.09748211
57MP0000653_abnormal_sex_gland1.08978646
58MP0009333_abnormal_splenocyte_physiolog1.08053739
59MP0000049_abnormal_middle_ear1.06921888
60MP0005253_abnormal_eye_physiology1.06248087
61MP0005171_absent_coat_pigmentation1.05754912
62MP0004133_heterotaxia1.04293164
63MP0000749_muscle_degeneration1.00339558
64MP0002697_abnormal_eye_size1.00187027
65MP0004134_abnormal_chest_morphology0.99356382
66MP0000371_diluted_coat_color0.98891255
67MP0000703_abnormal_thymus_morphology0.97240262
68MP0002090_abnormal_vision0.96315437
69MP0002638_abnormal_pupillary_reflex0.94192612
70MP0002160_abnormal_reproductive_system0.93508246
71MP0000358_abnormal_cell_content/0.91956056
72MP0004215_abnormal_myocardial_fiber0.90869574
73MP0008770_decreased_survivor_rate0.90015656
74MP0003937_abnormal_limbs/digits/tail_de0.89738456
75MP0003252_abnormal_bile_duct0.89491180
76MP0005384_cellular_phenotype0.89269785
77MP0009703_decreased_birth_body0.89187795
78MP0005389_reproductive_system_phenotype0.88316332
79MP0005397_hematopoietic_system_phenotyp0.87515450
80MP0001545_abnormal_hematopoietic_system0.87515450
81MP0005187_abnormal_penis_morphology0.86667843
82MP0003755_abnormal_palate_morphology0.85856105
83MP0005621_abnormal_cell_physiology0.85024795
84MP0005367_renal/urinary_system_phenotyp0.84982510
85MP0000516_abnormal_urinary_system0.84982510
86MP0006035_abnormal_mitochondrial_morpho0.84813326
87MP0000537_abnormal_urethra_morphology0.84448038
88MP0000613_abnormal_salivary_gland0.82206348
89MP0003136_yellow_coat_color0.81976635
90MP0005391_vision/eye_phenotype0.81925895
91MP0010030_abnormal_orbit_morphology0.81315765
92MP0009672_abnormal_birth_weight0.80163413
93MP0009250_abnormal_appendicular_skeleto0.79775690
94MP0001879_abnormal_lymphatic_vessel0.78981343
95MP0001529_abnormal_vocalization0.78304457
96MP0002095_abnormal_skin_pigmentation0.77681013
97MP0002111_abnormal_tail_morphology0.77046915
98MP0000383_abnormal_hair_follicle0.76772279
99MP0002928_abnormal_bile_duct0.76196483
100MP0003935_abnormal_craniofacial_develop0.76054518
101MP0003763_abnormal_thymus_physiology0.75795194
102MP0003221_abnormal_cardiomyocyte_apopto0.75371785
103MP0002722_abnormal_immune_system0.75040201
104MP0001119_abnormal_female_reproductive0.74929410
105MP0001485_abnormal_pinna_reflex0.73108268
106MP0002398_abnormal_bone_marrow0.72897379
107MP0005220_abnormal_exocrine_pancreas0.72424766
108MP0003195_calcinosis0.71800533
109MP0004264_abnormal_extraembryonic_tissu0.71376442
110MP0002938_white_spotting0.71305267
111MP0009764_decreased_sensitivity_to0.68822349
112MP0001324_abnormal_eye_pigmentation0.68799407
113MP0006072_abnormal_retinal_apoptosis0.68791787
114MP0001286_abnormal_eye_development0.68564309
115MP0002233_abnormal_nose_morphology0.68329250
116MP0000689_abnormal_spleen_morphology0.67999953
117MP0008260_abnormal_autophagy0.67585005
118MP0008995_early_reproductive_senescence0.66504009
119MP0003698_abnormal_male_reproductive0.65159186
120MP0001919_abnormal_reproductive_system0.65133504
121MP0002877_abnormal_melanocyte_morpholog0.64777853
122MP0003936_abnormal_reproductive_system0.63627437
123MP0000428_abnormal_craniofacial_morphol0.60693190
124MP0005266_abnormal_metabolism0.59860771
125MP0000432_abnormal_head_morphology0.59639322
126MP0001727_abnormal_embryo_implantation0.59210102
127MP0003950_abnormal_plasma_membrane0.59105784
128MP0009278_abnormal_bone_marrow0.58937977
129MP0002092_abnormal_eye_morphology0.56553215
130MP0005395_other_phenotype0.56316832
131MP0003861_abnormal_nervous_system0.55504075
132MP0000627_abnormal_mammary_gland0.55399368
133MP0002161_abnormal_fertility/fecundity0.55181796
134MP0001849_ear_inflammation0.53454304
135MP0002429_abnormal_blood_cell0.53412801
136MP0003566_abnormal_cell_adhesion0.52752474
137MP0000477_abnormal_intestine_morphology0.51699666
138MP0002075_abnormal_coat/hair_pigmentati0.51387087
139MP0001186_pigmentation_phenotype0.51130853
140MP0003699_abnormal_female_reproductive0.49083137

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.56471827
2Breast hypoplasia (HP:0003187)4.71951790
3Anomalous pulmonary venous return (HP:0010772)4.59723506
4Abnormality of the pulmonary veins (HP:0011718)4.09521096
5Ependymoma (HP:0002888)3.87590374
6Abnormality of the labia minora (HP:0012880)3.75996475
7Patellar aplasia (HP:0006443)3.73262386
8Chromsome breakage (HP:0040012)3.65616079
9Carpal bone hypoplasia (HP:0001498)3.63399624
10Aplasia/Hypoplasia of the patella (HP:0006498)3.51907307
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50880218
12Medulloblastoma (HP:0002885)3.49947478
13Colon cancer (HP:0003003)3.48144896
14Agnosia (HP:0010524)3.43732117
15Rough bone trabeculation (HP:0100670)3.36762803
16Absent radius (HP:0003974)3.33156048
17Reticulocytopenia (HP:0001896)3.31702614
18Abnormality of chromosome stability (HP:0003220)3.30339215
19Oral leukoplakia (HP:0002745)3.26843983
20Cerebral hypomyelination (HP:0006808)3.23175893
21Meckel diverticulum (HP:0002245)3.19370023
22Impulsivity (HP:0100710)3.17945761
23Abnormality of the preputium (HP:0100587)3.16477328
24Abnormality of cells of the erythroid lineage (HP:0012130)3.13866057
25Abnormality of the anterior horn cell (HP:0006802)3.13120402
26Degeneration of anterior horn cells (HP:0002398)3.13120402
27Aplasia involving forearm bones (HP:0009822)3.11612390
28Absent forearm bone (HP:0003953)3.11612390
29Abnormality of the ileum (HP:0001549)3.06368435
30Absent thumb (HP:0009777)3.03345102
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.92394983
32Selective tooth agenesis (HP:0001592)2.88464998
33Abnormal number of erythroid precursors (HP:0012131)2.83672764
34Abnormality of the carotid arteries (HP:0005344)2.82828991
35Premature graying of hair (HP:0002216)2.70618079
36Aplastic anemia (HP:0001915)2.67888895
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67371571
38Rhabdomyosarcoma (HP:0002859)2.67056690
39Myelomeningocele (HP:0002475)2.63569203
40Neoplasm of the pancreas (HP:0002894)2.62578507
41Bone marrow hypocellularity (HP:0005528)2.59084168
42Myelodysplasia (HP:0002863)2.58862936
43Hemivertebrae (HP:0002937)2.55489152
44Supernumerary spleens (HP:0009799)2.54901441
45Clubbing of toes (HP:0100760)2.54526141
46Abnormality of the pons (HP:0007361)2.51755932
47Neoplasm of the oral cavity (HP:0100649)2.49587248
48Glioma (HP:0009733)2.48539041
49Volvulus (HP:0002580)2.47886497
50Hypoplastic pelvis (HP:0008839)2.47777274
51Astrocytoma (HP:0009592)2.45636136
52Abnormality of the astrocytes (HP:0100707)2.45636136
53Hypoplasia of the pons (HP:0012110)2.44969738
54Duodenal stenosis (HP:0100867)2.44379714
55Small intestinal stenosis (HP:0012848)2.44379714
56Abnormal trabecular bone morphology (HP:0100671)2.44110050
57Horseshoe kidney (HP:0000085)2.44049057
58Basal cell carcinoma (HP:0002671)2.39584031
59Biliary tract neoplasm (HP:0100574)2.39582145
60Abnormality of DNA repair (HP:0003254)2.37324006
61Macrocytic anemia (HP:0001972)2.32296410
62Aplasia/hypoplasia of the humerus (HP:0006507)2.30571883
6311 pairs of ribs (HP:0000878)2.29734268
64Abnormality of the renal collecting system (HP:0004742)2.27198779
65Facial hemangioma (HP:0000329)2.25106021
66Nephroblastoma (Wilms tumor) (HP:0002667)2.25100064
67Calf muscle hypertrophy (HP:0008981)2.25044303
68Atresia of the external auditory canal (HP:0000413)2.23609128
69Proximal placement of thumb (HP:0009623)2.23196777
70Sloping forehead (HP:0000340)2.21491585
71Shoulder girdle muscle weakness (HP:0003547)2.20205442
72Stenosis of the external auditory canal (HP:0000402)2.17439039
73Short femoral neck (HP:0100864)2.15802649
74Abnormal number of incisors (HP:0011064)2.15364646
75Embryonal renal neoplasm (HP:0011794)2.15359766
76Cellular immunodeficiency (HP:0005374)2.15250625
77Tracheoesophageal fistula (HP:0002575)2.14874599
78Pelvic girdle muscle weakness (HP:0003749)2.13685492
79Missing ribs (HP:0000921)2.10773839
80Deviation of the thumb (HP:0009603)2.09824448
81Hemiplegia (HP:0002301)2.09019466
82Ectopic kidney (HP:0000086)2.08556264
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.08188610
84Secondary amenorrhea (HP:0000869)2.08144283
85Small hand (HP:0200055)2.07951330
86Microretrognathia (HP:0000308)2.07835162
87Premature ovarian failure (HP:0008209)2.05894164
88Cerebellar dysplasia (HP:0007033)2.05704780
89Rectovaginal fistula (HP:0000143)2.05490269
90Rectal fistula (HP:0100590)2.05490269
91Squamous cell carcinoma (HP:0002860)2.04580669
92Amaurosis fugax (HP:0100576)2.04150696
93Hypoplasia of the radius (HP:0002984)2.03084598
94Abnormality of the intervertebral disk (HP:0005108)2.02090242
95Abnormality of the hip-girdle musculature (HP:0001445)2.01835083
96Abnormality of the musculature of the pelvis (HP:0001469)2.01835083
97Short thumb (HP:0009778)2.01604221
98Triphalangeal thumb (HP:0001199)2.01404802
99CNS hypomyelination (HP:0003429)2.01108301
100Abnormality of the duodenum (HP:0002246)2.00712263
101Ureteral duplication (HP:0000073)1.98721274
102Trismus (HP:0000211)1.97681166
103Hepatocellular necrosis (HP:0001404)1.97474166
104Neoplasm of the colon (HP:0100273)1.96754125
105Cafe-au-lait spot (HP:0000957)1.96542810
106Spinal muscular atrophy (HP:0007269)1.95357791
107Vertebral fusion (HP:0002948)1.94793242
108Tongue fasciculations (HP:0001308)1.94673448
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.94197112
110Abdominal situs inversus (HP:0003363)1.94149353
111Abnormality of abdominal situs (HP:0011620)1.94149353
112Pancreatic cysts (HP:0001737)1.93659976
113Shawl scrotum (HP:0000049)1.93480840
114Abnormality of methionine metabolism (HP:0010901)1.92861841
115Leukodystrophy (HP:0002415)1.91912030
116Lipid accumulation in hepatocytes (HP:0006561)1.90036380
117Neoplasm of striated muscle (HP:0009728)1.89387905
118Lymphoma (HP:0002665)1.88905017
119Increased hepatocellular lipid droplets (HP:0006565)1.88797093
120Abnormal biliary tract morphology (HP:0012440)1.88463419
121Pallor (HP:0000980)1.88443089
122Muscle hypertrophy of the lower extremities (HP:0008968)1.87349541
123Prominent nose (HP:0000448)1.86304590
124Abnormal spermatogenesis (HP:0008669)1.84883376
125Duplicated collecting system (HP:0000081)1.83990378
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83684077
127Sparse lateral eyebrow (HP:0005338)1.82923599
128Short tibia (HP:0005736)1.82619746
129Oligodontia (HP:0000677)1.82017833
130Abnormal lung lobation (HP:0002101)1.81710407
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81577509
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.81548890
133Breast aplasia (HP:0100783)1.80615044
134Pancreatic fibrosis (HP:0100732)1.80590288
135Abnormality of the odontoid process (HP:0003310)1.78637409
136Short humerus (HP:0005792)1.78558004
137Increased nuchal translucency (HP:0010880)1.77963916
138Arteriovenous malformation (HP:0100026)1.77571639
139Increased CSF lactate (HP:0002490)1.76271686
140Hepatic necrosis (HP:0002605)1.75617160
141Morphological abnormality of the pyramidal tract (HP:0002062)1.74294281
142Abnormality of the proximal phalanges of the hand (HP:0009834)1.73252708
143Mitochondrial inheritance (HP:0001427)1.72294697
144Drooling (HP:0002307)1.72137936
145Postnatal growth retardation (HP:0008897)1.69994668
146Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68018261
147Type II lissencephaly (HP:0007260)1.67535211
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65224512
149Abnormality of alanine metabolism (HP:0010916)1.65224512
150Hyperalaninemia (HP:0003348)1.65224512
151Gonadotropin excess (HP:0000837)1.65201647
152True hermaphroditism (HP:0010459)1.64925459
153Meningioma (HP:0002858)1.63183291
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62601411
155Short 4th metacarpal (HP:0010044)1.62601411
156Pendular nystagmus (HP:0012043)1.57615478
157Renal cortical cysts (HP:0000803)1.57311423
158Meningocele (HP:0002435)1.56849389
159Diastasis recti (HP:0001540)1.56816437
160Duplication of thumb phalanx (HP:0009942)1.54294767
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.53979445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K45.11044858
2MAP2K75.09552228
3WEE14.94558453
4BUB14.60314645
5CDC74.06200287
6BLK3.69131609
7SRPK13.23193057
8TSSK63.16518269
9EIF2AK12.97636358
10PNCK2.90983178
11NEK22.51514255
12TTK2.51323508
13MAP2K42.48450943
14EPHA22.42469211
15NEK12.29211985
16BRSK22.20251504
17ACVR1B2.18102218
18PLK12.14593055
19CDK122.10959883
20PLK42.09915781
21PLK32.04538860
22RPS6KB21.94603919
23STK161.83872465
24PASK1.81742690
25EIF2AK31.77181238
26MKNK11.71868933
27DYRK31.70466475
28AKT31.70024715
29AURKB1.64750055
30VRK11.63196988
31ATR1.59382064
32MKNK21.57641439
33ZAK1.55906441
34TESK21.51670636
35CDK71.49886793
36CHEK21.48235303
37NME21.48014953
38TLK11.40713801
39TAF11.37760835
40TNIK1.36047377
41NUAK11.35702387
42BMPR1B1.31398904
43CHEK11.30937814
44BRSK11.27760862
45AURKA1.21739979
46BRD41.13926484
47MAP3K81.12202104
48TRIM281.11953059
49ERBB31.10192507
50CDK41.09522645
51CCNB11.06330222
52FRK1.04763797
53ATM1.00041550
54SCYL20.95870708
55BRAF0.94883720
56STK40.92892521
57* CDK20.91954645
58CAMK1G0.90556287
59ALK0.87602360
60TGFBR10.87369923
61STK38L0.86919402
62PLK20.84317999
63MELK0.81637296
64NEK90.80218498
65CSNK2A20.78917218
66PIM10.78591273
67PRKCI0.77647669
68STK100.77344397
69CAMK1D0.76266072
70PAK40.72579933
71RPS6KA40.69857781
72PDK30.69075357
73PDK40.69075357
74CSNK2A10.67835692
75* CDK10.67570854
76CAMKK20.64156417
77STK30.62696815
78EEF2K0.58329570
79CASK0.56407034
80RET0.56012396
81EIF2AK20.55406756
82LATS10.55209106
83CDK90.53253429
84CSNK1E0.53042604
85PAK10.53023902
86FLT30.52476663
87RPS6KA50.52473728
88ERBB40.52238231
89MST40.51406581
90DYRK20.48802923
91STK390.48610885
92OBSCN0.48371457
93MAPKAPK30.48140866
94PIM20.48111095
95LATS20.46838220
96MARK30.45145585
97PDK20.44517919
98VRK20.43649281
99PKN10.43342438
100IRAK30.42684728
101CSNK1A1L0.42461159
102PBK0.41516189
103GRK10.41512801
104NME10.40315948
105PRKDC0.40240028
106CDK30.38544715
107CDK60.37201267
108DAPK30.34776240
109FGFR10.34455240
110MTOR0.31839559
111CSNK1D0.30368914
112MAPK140.30290452
113CSNK1G20.29090482
114AKT20.28472151
115SGK20.27311032
116PRKAA10.26723257
117CSNK1G30.26528839
118BCR0.25412871
119TESK10.24014189
120CDK80.23729784
121GSK3B0.23125994
122RAF10.23007922
123MAP3K100.21489440
124STK240.20103809
125WNK30.20088180
126IRAK40.19949701
127RPS6KB10.17419874
128LIMK10.15781845
129CSNK1G10.15459646
130MAPK10.14980297
131AKT10.13184767
132MAPK100.12772375
133LRRK20.11034940
134MAP2K20.10620994

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.37147252
2Mismatch repair_Homo sapiens_hsa034304.26462226
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14713796
4Proteasome_Homo sapiens_hsa030503.73952916
5RNA polymerase_Homo sapiens_hsa030203.67586276
6RNA transport_Homo sapiens_hsa030133.43123986
7* Spliceosome_Homo sapiens_hsa030403.40868298
8Ribosome_Homo sapiens_hsa030103.12599574
9Homologous recombination_Homo sapiens_hsa034402.98145334
10Nucleotide excision repair_Homo sapiens_hsa034202.90909373
11Cell cycle_Homo sapiens_hsa041102.78976619
12Base excision repair_Homo sapiens_hsa034102.70522300
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57875854
14Fanconi anemia pathway_Homo sapiens_hsa034602.44038819
15Pyrimidine metabolism_Homo sapiens_hsa002402.37200226
16One carbon pool by folate_Homo sapiens_hsa006702.31666577
17Non-homologous end-joining_Homo sapiens_hsa034502.29158889
18Basal transcription factors_Homo sapiens_hsa030222.24358562
19RNA degradation_Homo sapiens_hsa030182.05120234
20mRNA surveillance pathway_Homo sapiens_hsa030151.89408167
21p53 signaling pathway_Homo sapiens_hsa041151.62521017
22Epstein-Barr virus infection_Homo sapiens_hsa051691.40648190
23Purine metabolism_Homo sapiens_hsa002301.35609387
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24372236
25Oocyte meiosis_Homo sapiens_hsa041141.15595519
26Antigen processing and presentation_Homo sapiens_hsa046121.10632938
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08591500
28Systemic lupus erythematosus_Homo sapiens_hsa053221.07466658
29Maturity onset diabetes of the young_Homo sapiens_hsa049500.98475012
30Viral carcinogenesis_Homo sapiens_hsa052030.97070126
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96466902
32Sulfur metabolism_Homo sapiens_hsa009200.96405983
33Vitamin B6 metabolism_Homo sapiens_hsa007500.94456998
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91236597
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88879647
36Protein export_Homo sapiens_hsa030600.88304310
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85390904
38Pentose phosphate pathway_Homo sapiens_hsa000300.85231123
39Alzheimers disease_Homo sapiens_hsa050100.83469322
40Herpes simplex infection_Homo sapiens_hsa051680.81635633
41Huntingtons disease_Homo sapiens_hsa050160.79518855
42Folate biosynthesis_Homo sapiens_hsa007900.77669364
43Regulation of autophagy_Homo sapiens_hsa041400.76091606
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75481866
45Propanoate metabolism_Homo sapiens_hsa006400.72631246
46Pyruvate metabolism_Homo sapiens_hsa006200.67792444
47Selenocompound metabolism_Homo sapiens_hsa004500.65747186
48HTLV-I infection_Homo sapiens_hsa051660.63166959
49Melanoma_Homo sapiens_hsa052180.60763445
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60153504
51Biosynthesis of amino acids_Homo sapiens_hsa012300.60045271
52Steroid biosynthesis_Homo sapiens_hsa001000.59574285
53Thyroid cancer_Homo sapiens_hsa052160.59071587
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.58100508
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56989824
56Fructose and mannose metabolism_Homo sapiens_hsa000510.56517395
57MicroRNAs in cancer_Homo sapiens_hsa052060.54223350
58Circadian rhythm_Homo sapiens_hsa047100.51877955
59Parkinsons disease_Homo sapiens_hsa050120.51452249
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51124322
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50992675
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49994709
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49049213
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45319681
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.45234163
66Alcoholism_Homo sapiens_hsa050340.44116821
67Hippo signaling pathway_Homo sapiens_hsa043900.42216440
68Primary immunodeficiency_Homo sapiens_hsa053400.42108920
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.41723023
70TGF-beta signaling pathway_Homo sapiens_hsa043500.40743297
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39068539
72Colorectal cancer_Homo sapiens_hsa052100.38503850
73Lysine degradation_Homo sapiens_hsa003100.38433921
74Legionellosis_Homo sapiens_hsa051340.38222278
75Butanoate metabolism_Homo sapiens_hsa006500.38041142
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37194206
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37154814
78Oxidative phosphorylation_Homo sapiens_hsa001900.35922158
79Small cell lung cancer_Homo sapiens_hsa052220.35541571
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35490674
81Cardiac muscle contraction_Homo sapiens_hsa042600.32572735
82Glutathione metabolism_Homo sapiens_hsa004800.31457299
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29703607
84Apoptosis_Homo sapiens_hsa042100.29041018
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29012698
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28844867
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28713960
88Dorso-ventral axis formation_Homo sapiens_hsa043200.27451849
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26470641
90Notch signaling pathway_Homo sapiens_hsa043300.26363385
91mTOR signaling pathway_Homo sapiens_hsa041500.25230092
92Carbon metabolism_Homo sapiens_hsa012000.24912964
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24692652
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.24670847
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24043665
96Type II diabetes mellitus_Homo sapiens_hsa049300.23951455
97Adherens junction_Homo sapiens_hsa045200.23553854
98HIF-1 signaling pathway_Homo sapiens_hsa040660.23030645
99Prostate cancer_Homo sapiens_hsa052150.21981385
100Tight junction_Homo sapiens_hsa045300.21638784
101Tryptophan metabolism_Homo sapiens_hsa003800.21379311
102Pathways in cancer_Homo sapiens_hsa052000.21334307
103Shigellosis_Homo sapiens_hsa051310.21287567
104Renin-angiotensin system_Homo sapiens_hsa046140.21219747
105Insulin secretion_Homo sapiens_hsa049110.21176563
106Hepatitis B_Homo sapiens_hsa051610.19757260
107Hedgehog signaling pathway_Homo sapiens_hsa043400.19610777
108Measles_Homo sapiens_hsa051620.19279783
109Basal cell carcinoma_Homo sapiens_hsa052170.19250327
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18907390
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18561900
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17172554
113Sulfur relay system_Homo sapiens_hsa041220.15926148
114Ovarian steroidogenesis_Homo sapiens_hsa049130.15266444
115Galactose metabolism_Homo sapiens_hsa000520.15057706
116Metabolic pathways_Homo sapiens_hsa011000.14816739
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14688686
118Pancreatic cancer_Homo sapiens_hsa052120.14224540
119Olfactory transduction_Homo sapiens_hsa047400.13625660
120FoxO signaling pathway_Homo sapiens_hsa040680.13425976
121Thyroid hormone synthesis_Homo sapiens_hsa049180.13189357
122Influenza A_Homo sapiens_hsa051640.13095955
123Prolactin signaling pathway_Homo sapiens_hsa049170.12796679
124Allograft rejection_Homo sapiens_hsa053300.12425679
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12320496
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11407580
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11338322
128Peroxisome_Homo sapiens_hsa041460.11070449
129Graft-versus-host disease_Homo sapiens_hsa053320.10577237
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.10548514
131N-Glycan biosynthesis_Homo sapiens_hsa005100.09372001
132Wnt signaling pathway_Homo sapiens_hsa043100.09162986
133Type I diabetes mellitus_Homo sapiens_hsa049400.08693638
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08484161
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.08217031
136Viral myocarditis_Homo sapiens_hsa054160.07779606
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.05823534

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