CDC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.85579723
2DNA strand elongation involved in DNA replication (GO:0006271)5.83139138
3telomere maintenance via semi-conservative replication (GO:0032201)5.60293904
4DNA strand elongation (GO:0022616)5.52419753
5DNA replication initiation (GO:0006270)5.36963520
6mitotic recombination (GO:0006312)5.24105601
7telomere maintenance via recombination (GO:0000722)5.18847734
8DNA replication checkpoint (GO:0000076)5.17883463
9protein localization to kinetochore (GO:0034501)5.14112821
10CENP-A containing nucleosome assembly (GO:0034080)4.87559161
11mitotic chromosome condensation (GO:0007076)4.80862544
12DNA double-strand break processing (GO:0000729)4.80848244
13chromatin remodeling at centromere (GO:0031055)4.80595349
14kinetochore organization (GO:0051383)4.74330916
15attachment of spindle microtubules to kinetochore (GO:0008608)4.54335848
16nucleotide-excision repair, DNA gap filling (GO:0006297)4.53598580
17DNA replication-independent nucleosome organization (GO:0034724)4.52133123
18DNA replication-independent nucleosome assembly (GO:0006336)4.52133123
19protein localization to chromosome, centromeric region (GO:0071459)4.51013807
20telomere maintenance via telomere lengthening (GO:0010833)4.41280935
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.40150804
22mitotic metaphase plate congression (GO:0007080)4.36374191
23meiotic chromosome segregation (GO:0045132)4.27827158
24mitotic sister chromatid segregation (GO:0000070)4.17707035
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.09109664
26regulation of double-strand break repair via homologous recombination (GO:0010569)4.08079439
27histone exchange (GO:0043486)4.07510483
28sister chromatid segregation (GO:0000819)4.05797947
29metaphase plate congression (GO:0051310)4.01567062
30kinetochore assembly (GO:0051382)3.94918882
31nucleobase biosynthetic process (GO:0046112)3.87613237
32pore complex assembly (GO:0046931)3.84900929
33double-strand break repair via nonhomologous end joining (GO:0006303)3.84566363
34non-recombinational repair (GO:0000726)3.84566363
35DNA replication-dependent nucleosome assembly (GO:0006335)3.82801286
36DNA replication-dependent nucleosome organization (GO:0034723)3.82801286
37heterochromatin organization (GO:0070828)3.81000319
38nuclear pore organization (GO:0006999)3.79438404
39IMP biosynthetic process (GO:0006188)3.75329947
40DNA topological change (GO:0006265)3.74642584
41establishment of chromosome localization (GO:0051303)3.73987930
42mitotic sister chromatid cohesion (GO:0007064)3.72954123
43mismatch repair (GO:0006298)3.63789513
44telomere maintenance (GO:0000723)3.63428649
45telomere organization (GO:0032200)3.61571956
46DNA geometric change (GO:0032392)3.61222355
47DNA duplex unwinding (GO:0032508)3.60506628
48nuclear pore complex assembly (GO:0051292)3.59833718
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59820607
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57811212
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.57811212
52mitotic nuclear envelope disassembly (GO:0007077)3.52810275
53microtubule depolymerization (GO:0007019)3.51888742
54* regulation of nuclear cell cycle DNA replication (GO:0033262)3.51856444
55translesion synthesis (GO:0019985)3.47368899
56spindle checkpoint (GO:0031577)3.46856188
57purine nucleobase biosynthetic process (GO:0009113)3.43373349
58chromatin assembly or disassembly (GO:0006333)3.42444534
59regulation of DNA endoreduplication (GO:0032875)3.39843304
60chromosome segregation (GO:0007059)3.34805455
61DNA catabolic process, exonucleolytic (GO:0000738)3.34734756
62negative regulation of chromosome segregation (GO:0051985)3.32997035
63regulation of sister chromatid cohesion (GO:0007063)3.32464008
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.32385167
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32385167
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32385167
67negative regulation of sister chromatid segregation (GO:0033046)3.32385167
68regulation of chromosome segregation (GO:0051983)3.31535203
69protein localization to chromosome (GO:0034502)3.30566467
70spindle assembly checkpoint (GO:0071173)3.30209850
71ATP-dependent chromatin remodeling (GO:0043044)3.29844742
72DNA conformation change (GO:0071103)3.29769205
73regulation of centrosome cycle (GO:0046605)3.27757242
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.26989273
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25313670
76membrane disassembly (GO:0030397)3.25174138
77nuclear envelope disassembly (GO:0051081)3.25174138
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24341128
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24101589
80regulation of centriole replication (GO:0046599)3.24084361
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23985109
82centriole replication (GO:0007099)3.21744317
83deoxyribonucleotide biosynthetic process (GO:0009263)3.21204821
84histone-serine phosphorylation (GO:0035404)3.19088662
85positive regulation of chromosome segregation (GO:0051984)3.19045495
86establishment of integrated proviral latency (GO:0075713)3.18548784
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17798898
88mitotic spindle assembly checkpoint (GO:0007094)3.17623557
89regulation of spindle checkpoint (GO:0090231)3.17550677
90regulation of double-strand break repair (GO:2000779)3.17550402
91DNA ligation (GO:0006266)3.17235869
92regulation of spindle organization (GO:0090224)3.17188335
93postreplication repair (GO:0006301)3.16982077
94replication fork processing (GO:0031297)3.16978157
95regulation of helicase activity (GO:0051095)3.16781509
96mitotic spindle checkpoint (GO:0071174)3.16745754
97DNA synthesis involved in DNA repair (GO:0000731)3.16583547
98base-excision repair (GO:0006284)3.16465663
99termination of RNA polymerase II transcription (GO:0006369)3.16459899
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16286369
101intra-S DNA damage checkpoint (GO:0031573)3.15047924
102chromosome condensation (GO:0030261)3.14946257
103establishment of viral latency (GO:0019043)3.14083157
104regulation of mitotic sister chromatid separation (GO:0010965)3.13211264
105regulation of mitotic sister chromatid segregation (GO:0033047)3.13211264
106regulation of sister chromatid segregation (GO:0033045)3.13211264
107transcription-coupled nucleotide-excision repair (GO:0006283)3.10310401
108negative regulation of mRNA processing (GO:0050686)3.09913027
109ribosome assembly (GO:0042255)3.09697821
110IMP metabolic process (GO:0046040)3.09196965
111negative regulation of DNA recombination (GO:0045910)3.07220259
112* mitotic cell cycle (GO:0000278)3.07036047
113DNA strand renaturation (GO:0000733)3.06640325
114regulation of mitotic spindle checkpoint (GO:1903504)3.03781632
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03781632
116histone H2A acetylation (GO:0043968)3.03749123
117DNA packaging (GO:0006323)3.03450186
118* DNA replication (GO:0006260)3.02924460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.45104352
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.94029530
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.76688203
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.52418170
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06662162
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68678474
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.62328681
8* E2F1_21310950_ChIP-Seq_MCF-7_Human2.57716512
9* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52527515
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48362074
11* AR_21909140_ChIP-Seq_LNCAP_Human2.45265645
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43788811
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39337158
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32113915
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29333040
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26031784
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19233619
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.14639103
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.13530798
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10183454
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09962787
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.09156361
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08551097
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08089543
25E2F7_22180533_ChIP-Seq_HELA_Human12.9130565
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98716001
27VDR_23849224_ChIP-Seq_CD4+_Human1.95785551
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95323291
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88902364
30FOXP3_21729870_ChIP-Seq_TREG_Human1.88657572
31* XRN2_22483619_ChIP-Seq_HELA_Human1.86523393
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86244803
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80983269
34CIITA_25753668_ChIP-Seq_RAJI_Human1.79241517
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78587363
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72608065
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.67843728
38ELK1_19687146_ChIP-ChIP_HELA_Human1.67786337
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62863424
40DCP1A_22483619_ChIP-Seq_HELA_Human1.62593652
41TTF2_22483619_ChIP-Seq_HELA_Human1.61640552
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60926108
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59001523
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55509925
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55080781
46* GABP_19822575_ChIP-Seq_HepG2_Human1.53727922
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52870854
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52785687
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49332647
50FUS_26573619_Chip-Seq_HEK293_Human1.31354074
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31084872
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30771870
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30152459
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29510668
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29493721
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.28116788
57KDM5A_27292631_Chip-Seq_BREAST_Human1.28040917
58MYC_22102868_ChIP-Seq_BL_Human1.25397602
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22672659
60* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22304701
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.20782475
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19608871
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18859314
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18287136
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.17398538
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16291022
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16032276
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06477543
69* MYC_18940864_ChIP-ChIP_HL60_Human1.05672458
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04471063
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04280753
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04280753
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04280753
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02038909
75ZNF274_21170338_ChIP-Seq_K562_Hela1.01696924
76* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00228919
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97887024
78EWS_26573619_Chip-Seq_HEK293_Human0.93030171
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87489869
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86479986
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.86184429
82SPI1_23547873_ChIP-Seq_NB4_Human0.85862126
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85530914
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85448787
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84563390
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84500723
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.84158154
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81808581
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80432604
90TFEB_21752829_ChIP-Seq_HELA_Human0.80320815
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79170290
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78981516
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77560499
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.74463708
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74051831
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.73841328
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73667117
98* SOX2_16153702_ChIP-ChIP_HESCs_Human0.73054052
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72334014
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69660767
101VDR_21846776_ChIP-Seq_THP-1_Human0.69300221
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69046432
103* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68642835
104* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68228141
105IGF1R_20145208_ChIP-Seq_DFB_Human0.66477868
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65975071
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64364080
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63686943
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.63623006
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.63043580
111TAF15_26573619_Chip-Seq_HEK293_Human0.63035599
112* CHD1_26751641_Chip-Seq_LNCaP_Human0.63007545
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.62010486
114SCL_19346495_ChIP-Seq_HPC-7_Human0.60434858
115* NANOG_16153702_ChIP-ChIP_HESCs_Human0.58169597
116IRF1_19129219_ChIP-ChIP_H3396_Human0.57894629
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.57504427
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56272249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.54681222
2MP0003693_abnormal_embryo_hatching4.76003981
3MP0003111_abnormal_nucleus_morphology4.70889443
4* MP0008057_abnormal_DNA_replication4.23545097
5* MP0003077_abnormal_cell_cycle3.95556339
6MP0008058_abnormal_DNA_repair3.79473784
7* MP0004957_abnormal_blastocyst_morpholog3.68983974
8MP0008877_abnormal_DNA_methylation3.45084291
9MP0003123_paternal_imprinting3.34822310
10MP0008007_abnormal_cellular_replicative2.99705525
11MP0008932_abnormal_embryonic_tissue2.73895421
12MP0003121_genomic_imprinting2.70344854
13MP0002396_abnormal_hematopoietic_system2.63771870
14MP0003787_abnormal_imprinting2.40801471
15MP0000350_abnormal_cell_proliferation2.12770450
16MP0001730_embryonic_growth_arrest1.89019745
17MP0003786_premature_aging1.75483383
18MP0003890_abnormal_embryonic-extraembry1.70517563
19MP0004808_abnormal_hematopoietic_stem1.67392551
20MP0000490_abnormal_crypts_of1.61488769
21MP0010307_abnormal_tumor_latency1.59298416
22MP0001346_abnormal_lacrimal_gland1.49361961
23* MP0002210_abnormal_sex_determination1.49172067
24MP0001672_abnormal_embryogenesis/_devel1.46780234
25MP0005380_embryogenesis_phenotype1.46780234
26* MP0001697_abnormal_embryo_size1.45401669
27MP0009697_abnormal_copulation1.42973711
28MP0006292_abnormal_olfactory_placode1.40411808
29MP0004197_abnormal_fetal_growth/weight/1.35266726
30MP0003763_abnormal_thymus_physiology1.34445002
31MP0002085_abnormal_embryonic_tissue1.34198116
32MP0000313_abnormal_cell_death1.32708917
33MP0010352_gastrointestinal_tract_polyps1.31536092
34* MP0002080_prenatal_lethality1.29191001
35MP0008995_early_reproductive_senescence1.28823523
36MP0003984_embryonic_growth_retardation1.27454035
37MP0003122_maternal_imprinting1.26476281
38MP0002019_abnormal_tumor_incidence1.26170709
39* MP0001929_abnormal_gametogenesis1.25413858
40MP0003315_abnormal_perineum_morphology1.24576074
41MP0000703_abnormal_thymus_morphology1.24273959
42MP0002088_abnormal_embryonic_growth/wei1.22951193
43* MP0001145_abnormal_male_reproductive1.22722497
44MP0002697_abnormal_eye_size1.19918074
45MP0002102_abnormal_ear_morphology1.17659364
46MP0002234_abnormal_pharynx_morphology1.15500315
47MP0002398_abnormal_bone_marrow1.15236475
48MP0002084_abnormal_developmental_patter1.14958220
49MP0002233_abnormal_nose_morphology1.12921885
50MP0008789_abnormal_olfactory_epithelium1.11611054
51MP0006035_abnormal_mitochondrial_morpho1.10686063
52* MP0000653_abnormal_sex_gland1.08850531
53MP0001188_hyperpigmentation1.07681089
54MP0002086_abnormal_extraembryonic_tissu1.06647172
55MP0000049_abnormal_middle_ear1.01486372
56MP0001293_anophthalmia1.00818659
57MP0000569_abnormal_digit_pigmentation0.99546924
58MP0009053_abnormal_anal_canal0.99282536
59* MP0001119_abnormal_female_reproductive0.99040673
60MP0002938_white_spotting0.98615263
61MP0005187_abnormal_penis_morphology0.98209938
62MP0003941_abnormal_skin_development0.97192712
63MP0002722_abnormal_immune_system0.95893331
64MP0003567_abnormal_fetal_cardiomyocyte0.95608400
65MP0005499_abnormal_olfactory_system0.94434584
66MP0005394_taste/olfaction_phenotype0.94434584
67MP0002160_abnormal_reproductive_system0.94306143
68* MP0002111_abnormal_tail_morphology0.93542436
69MP0001177_atelectasis0.93084786
70MP0002092_abnormal_eye_morphology0.91374343
71MP0000015_abnormal_ear_pigmentation0.91336098
72MP0000689_abnormal_spleen_morphology0.91145363
73MP0001545_abnormal_hematopoietic_system0.90499508
74MP0005397_hematopoietic_system_phenotyp0.90499508
75MP0000566_synostosis0.90400116
76MP0002095_abnormal_skin_pigmentation0.90144587
77MP0005174_abnormal_tail_pigmentation0.88824688
78MP0003698_abnormal_male_reproductive0.85686013
79MP0001529_abnormal_vocalization0.83855033
80MP0000428_abnormal_craniofacial_morphol0.82719805
81MP0000358_abnormal_cell_content/0.81938419
82MP0003755_abnormal_palate_morphology0.81394122
83MP0002736_abnormal_nociception_after0.80016064
84MP0000647_abnormal_sebaceous_gland0.78856437
85MP0002429_abnormal_blood_cell0.78849790
86MP0009672_abnormal_birth_weight0.78060536
87MP0003937_abnormal_limbs/digits/tail_de0.76574509
88MP0003119_abnormal_digestive_system0.76415067
89MP0003221_abnormal_cardiomyocyte_apopto0.76298541
90MP0005391_vision/eye_phenotype0.76061198
91MP0009333_abnormal_splenocyte_physiolog0.75022672
92MP0003935_abnormal_craniofacial_develop0.74581660
93MP0009703_decreased_birth_body0.72514221
94MP0003950_abnormal_plasma_membrane0.72130885
95MP0005395_other_phenotype0.71897544
96MP0004147_increased_porphyrin_level0.71889257
97MP0006054_spinal_hemorrhage0.71606663
98MP0005076_abnormal_cell_differentiation0.71399855
99MP0002163_abnormal_gland_morphology0.71170279
100MP0005671_abnormal_response_to0.69737198
101MP0003938_abnormal_ear_development0.69267988
102MP0000716_abnormal_immune_system0.69063844
103MP0005389_reproductive_system_phenotype0.68890536
104MP0002009_preneoplasia0.66853536
105MP0003385_abnormal_body_wall0.65975420
106MP0010030_abnormal_orbit_morphology0.63523456
107MP0003718_maternal_effect0.63262269
108MP0002081_perinatal_lethality0.63207116
109MP0002075_abnormal_coat/hair_pigmentati0.62962293
110MP0000537_abnormal_urethra_morphology0.62847895
111* MP0005384_cellular_phenotype0.62564060
112MP0003861_abnormal_nervous_system0.62547593
113MP0005647_abnormal_sex_gland0.62494701
114MP0002751_abnormal_autonomic_nervous0.62350293
115MP0002161_abnormal_fertility/fecundity0.62194590
116MP0001835_abnormal_antigen_presentation0.60948708
117MP0008260_abnormal_autophagy0.60941115
118MP0000432_abnormal_head_morphology0.60597496
119MP0002114_abnormal_axial_skeleton0.60577006
120MP0000778_abnormal_nervous_system0.57924444
121MP0006072_abnormal_retinal_apoptosis0.57828809
122MP0003943_abnormal_hepatobiliary_system0.57315797
123MP0001800_abnormal_humoral_immune0.56378958
124MP0002420_abnormal_adaptive_immunity0.55813448
125MP0001286_abnormal_eye_development0.55763187
126MP0001819_abnormal_immune_cell0.54335935
127MP0001186_pigmentation_phenotype0.53787479
128MP0000631_abnormal_neuroendocrine_gland0.53171616
129MP0003115_abnormal_respiratory_system0.51783767
130MP0000465_gastrointestinal_hemorrhage0.51500557
131MP0003136_yellow_coat_color0.51079641
132MP0003699_abnormal_female_reproductive0.50347714

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.69309437
2Chromsome breakage (HP:0040012)5.64993794
3Birth length less than 3rd percentile (HP:0003561)4.67195128
4Abnormality of chromosome stability (HP:0003220)4.25193835
5Meckel diverticulum (HP:0002245)4.14937364
6Abnormality of the ileum (HP:0001549)3.90963157
7Abnormality of the preputium (HP:0100587)3.83257136
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.82808058
9Colon cancer (HP:0003003)3.51019375
10Ectopic kidney (HP:0000086)3.29534905
11Duodenal stenosis (HP:0100867)3.28509004
12Small intestinal stenosis (HP:0012848)3.28509004
13Reticulocytopenia (HP:0001896)3.23552022
14Medulloblastoma (HP:0002885)3.20684682
15Nephroblastoma (Wilms tumor) (HP:0002667)3.14913001
16Patellar aplasia (HP:0006443)3.13247801
17Myelodysplasia (HP:0002863)3.01026346
18Embryonal renal neoplasm (HP:0011794)2.93219690
19Bone marrow hypocellularity (HP:0005528)2.92360582
20Abnormality of the carotid arteries (HP:0005344)2.91638761
21Aplastic anemia (HP:0001915)2.91288327
22Aplasia/Hypoplasia of the patella (HP:0006498)2.90567317
23Cortical dysplasia (HP:0002539)2.89643468
24Abnormality of the lower motor neuron (HP:0002366)2.87539850
25Duplicated collecting system (HP:0000081)2.82978369
26Abnormality of the renal collecting system (HP:0004742)2.79110125
27Volvulus (HP:0002580)2.76802597
28Abnormality of the duodenum (HP:0002246)2.71540733
29Clubbing of toes (HP:0100760)2.67411636
30Abnormal number of incisors (HP:0011064)2.59708374
31Abnormal lung lobation (HP:0002101)2.59514026
32Breast hypoplasia (HP:0003187)2.57505735
33Sloping forehead (HP:0000340)2.55834050
34Agnosia (HP:0010524)2.55411588
35Impulsivity (HP:0100710)2.53763864
36Short 4th metacarpal (HP:0010044)2.52028942
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52028942
38Increased nuchal translucency (HP:0010880)2.51067685
3911 pairs of ribs (HP:0000878)2.50700754
40Multiple enchondromatosis (HP:0005701)2.50215766
41Ependymoma (HP:0002888)2.45695993
42Oligodactyly (hands) (HP:0001180)2.38619969
43Abnormality of the labia minora (HP:0012880)2.36697454
44Tracheoesophageal fistula (HP:0002575)2.35131139
45Abnormal number of erythroid precursors (HP:0012131)2.33390842
46Premature graying of hair (HP:0002216)2.31096867
47Supernumerary spleens (HP:0009799)2.30360617
48Absent radius (HP:0003974)2.29849449
49Amyotrophic lateral sclerosis (HP:0007354)2.29003596
50Short thumb (HP:0009778)2.28985083
51Oral leukoplakia (HP:0002745)2.26001215
52Aplasia involving forearm bones (HP:0009822)2.25297264
53Absent forearm bone (HP:0003953)2.25297264
54Absent thumb (HP:0009777)2.24615916
55Abnormality of cochlea (HP:0000375)2.20864958
56Triphalangeal thumb (HP:0001199)2.20467855
57Abnormality of DNA repair (HP:0003254)2.18829510
58Abnormality of cells of the erythroid lineage (HP:0012130)2.17651948
59Upper motor neuron abnormality (HP:0002127)2.15012667
60Selective tooth agenesis (HP:0001592)2.14342615
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.13405535
62Cafe-au-lait spot (HP:0000957)2.12471525
63Oligodactyly (HP:0012165)2.11819917
64Lymphoma (HP:0002665)2.10502286
65Duplication of thumb phalanx (HP:0009942)2.10451583
66Septo-optic dysplasia (HP:0100842)2.02737219
67IgM deficiency (HP:0002850)2.01852031
68Choanal atresia (HP:0000453)2.00638736
69Intestinal atresia (HP:0011100)1.99276629
70Diastasis recti (HP:0001540)1.97360110
71Severe visual impairment (HP:0001141)1.96148504
72Cellular immunodeficiency (HP:0005374)1.95232336
73Neoplasm of the pancreas (HP:0002894)1.94509392
74Acute lymphatic leukemia (HP:0006721)1.94106898
75Broad palm (HP:0001169)1.93833018
76Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91519686
77Rough bone trabeculation (HP:0100670)1.91435791
78Abnormality of the septum pellucidum (HP:0007375)1.91399332
79Abnormality of methionine metabolism (HP:0010901)1.90186083
80Abnormality of chromosome segregation (HP:0002916)1.89492385
81Horseshoe kidney (HP:0000085)1.88769746
82Glioma (HP:0009733)1.88163962
83Abnormality of the anterior horn cell (HP:0006802)1.87648187
84Degeneration of anterior horn cells (HP:0002398)1.87648187
85Conjunctival telangiectasia (HP:0000524)1.86228531
86Proximal placement of thumb (HP:0009623)1.86204258
87Rhabdomyosarcoma (HP:0002859)1.84519612
88Morphological abnormality of the inner ear (HP:0011390)1.83790848
89High anterior hairline (HP:0009890)1.82568306
90Abnormality of the fingertips (HP:0001211)1.81676533
91Pendular nystagmus (HP:0012043)1.81518356
92Microvesicular hepatic steatosis (HP:0001414)1.80556476
93Atresia of the external auditory canal (HP:0000413)1.80514448
94Neoplasm of the colon (HP:0100273)1.80385692
95Esophageal atresia (HP:0002032)1.79987419
96Deviation of the thumb (HP:0009603)1.79721491
97Long clavicles (HP:0000890)1.79372067
98Arteriovenous malformation (HP:0100026)1.78399296
99Absent septum pellucidum (HP:0001331)1.77834784
100Optic nerve coloboma (HP:0000588)1.77534309
101Stenosis of the external auditory canal (HP:0000402)1.77519598
102Abnormal hair whorl (HP:0010721)1.76958651
103Pancytopenia (HP:0001876)1.76507586
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.75422281
105Impaired proprioception (HP:0010831)1.74629585
106Gastrointestinal atresia (HP:0002589)1.73628120
107Neoplasm of the oral cavity (HP:0100649)1.73226608
108Microtia (HP:0008551)1.73078139
109High pitched voice (HP:0001620)1.72076684
110Abnormality of the astrocytes (HP:0100707)1.71920568
111Astrocytoma (HP:0009592)1.71920568
112Rectovaginal fistula (HP:0000143)1.71789011
113Rectal fistula (HP:0100590)1.71789011
114Abnormality of the incisor (HP:0000676)1.70628351
115Slender long bone (HP:0003100)1.68030918
116Facial cleft (HP:0002006)1.67409146
117Abnormality of glycolysis (HP:0004366)1.67389340
118Deep philtrum (HP:0002002)1.66824925
119Carpal bone hypoplasia (HP:0001498)1.65304836
120Basal cell carcinoma (HP:0002671)1.65232146
121Facial hemangioma (HP:0000329)1.65019164
122Aplasia/Hypoplasia of the earlobes (HP:0009906)1.64626137
123Hepatoblastoma (HP:0002884)1.64405869
124Short middle phalanx of the 5th finger (HP:0004220)1.63815101
125Leukopenia (HP:0001882)1.63291975
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62679264
127Embryonal neoplasm (HP:0002898)1.62392306
128Pancreatic islet-cell hyperplasia (HP:0004510)1.61369191
129Hyperglycinemia (HP:0002154)1.61269473
130Cerebral hypomyelination (HP:0006808)1.59899845
131Increased serum pyruvate (HP:0003542)1.59838807
132Neoplasm of the adrenal cortex (HP:0100641)1.59758556
133Urethral obstruction (HP:0000796)1.59664401
134Prominent nose (HP:0000448)1.59514185
135Ovarian neoplasm (HP:0100615)1.59156985
136Abnormality of abdominal situs (HP:0011620)1.59088497
137Abdominal situs inversus (HP:0003363)1.59088497
138Small hand (HP:0200055)1.58008776
139Overlapping toe (HP:0001845)1.57831262
140Neoplasm of the adrenal gland (HP:0100631)1.57779952
141Cleft eyelid (HP:0000625)1.57670748
142Spastic diplegia (HP:0001264)1.56404284
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56372040
144Preaxial hand polydactyly (HP:0001177)1.54728489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.64147142
2WEE14.66305468
3BUB13.82204820
4BRSK23.10332889
5NEK23.03603138
6SRPK12.75136618
7CCNB12.64703128
8ACVR1B2.45225150
9MKNK12.42427219
10TRIM282.33590744
11PLK12.26858222
12TTK2.21387554
13BRSK12.21064247
14PLK42.18218769
15ATR2.15542622
16TSSK62.12679435
17MKNK22.08111306
18EIF2AK12.04487689
19PASK2.03503422
20NEK11.98173105
21VRK21.96349725
22VRK11.90359826
23PLK31.88209054
24TAF11.82840187
25AURKB1.77476316
26TNIK1.76094739
27CHEK21.71363368
28CDK71.61797025
29BCR1.60150582
30CLK11.48448057
31EIF2AK31.48005619
32CHEK11.45911359
33ZAK1.44834189
34BRD41.42397573
35CDK41.39633106
36STK161.31426492
37CDK121.30805241
38NUAK11.29070859
39WNK31.26991406
40DYRK31.25130717
41STK41.21908735
42EIF2AK21.21114587
43CDK81.18086021
44MST41.14572699
45ATM1.14315871
46AURKA1.12992898
47TLK11.09143989
48ERBB31.04812415
49EPHA41.02678890
50MELK0.97121944
51TGFBR10.96368787
52* CDK20.91796213
53IRAK40.87820097
54DAPK10.87209710
55MAP3K80.86820557
56CAMK1G0.84986412
57NME10.84888514
58MAP4K10.84505949
59RPS6KA40.83763499
60* CDK10.83283249
61YES10.82293635
62CSNK1G10.75389906
63RPS6KB20.75143182
64PIM10.68827184
65CSF1R0.68385291
66CSNK1G30.66882700
67CASK0.66826035
68STK38L0.66510516
69BMPR1B0.63628946
70BRAF0.62841143
71TXK0.61660081
72CSNK2A10.61391655
73MAPK130.59184827
74NME20.58706299
75NEK90.57744112
76CSNK2A20.56013416
77FLT30.55243669
78CDK60.54556488
79LATS10.53988822
80CSNK1G20.53894659
81PAK40.53454888
82DYRK20.53437223
83PNCK0.53424019
84STK100.52712176
85CSNK1E0.52286979
86PRKDC0.51277350
87BTK0.50395987
88EEF2K0.48805191
89CSNK1A1L0.48176660
90PLK20.47768649
91TAOK20.46627299
92RPS6KB10.46599862
93SCYL20.45778054
94CAMK1D0.45031537
95CDK30.43344065
96ERBB40.42127364
97SMG10.41464498
98TEC0.40260249
99TESK20.37066547
100MAPK140.36848621
101MAP3K40.36847106
102UHMK10.36156479
103CDK180.34440733
104RAF10.34408074
105CDK11A0.34063989
106MAP2K70.33352771
107ALK0.32494882
108CDK150.31971978
109STK240.29793734
110FGFR20.28636327
111MAP3K100.28600266
112LYN0.28241655
113BCKDK0.28024253
114PDK20.26441202
115JAK30.26175642
116CSNK1D0.26135823
117MINK10.24812448
118PBK0.24809628
119GSK3B0.24653576
120RPS6KC10.24492301
121RPS6KL10.24492301
122AKT10.24343674
123RPS6KA60.23002110
124TRPM70.22603824
125STK30.22450836
126FGFR10.22412610
127CDK90.21546892
128KIT0.21310072
129RPS6KA50.20914891
130AKT20.20186939
131CDK140.19358515

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.89668811
2Mismatch repair_Homo sapiens_hsa034304.86607336
3Homologous recombination_Homo sapiens_hsa034403.80762835
4Base excision repair_Homo sapiens_hsa034103.59313005
5* Cell cycle_Homo sapiens_hsa041103.25651561
6Spliceosome_Homo sapiens_hsa030403.14532079
7Nucleotide excision repair_Homo sapiens_hsa034203.07461794
8Fanconi anemia pathway_Homo sapiens_hsa034603.07170363
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97887638
10Non-homologous end-joining_Homo sapiens_hsa034502.95912180
11RNA transport_Homo sapiens_hsa030132.64680902
12RNA polymerase_Homo sapiens_hsa030202.53930364
13Pyrimidine metabolism_Homo sapiens_hsa002402.35171140
14Proteasome_Homo sapiens_hsa030502.12173640
15One carbon pool by folate_Homo sapiens_hsa006702.10865885
16RNA degradation_Homo sapiens_hsa030181.97929083
17mRNA surveillance pathway_Homo sapiens_hsa030151.96663303
18Basal transcription factors_Homo sapiens_hsa030221.95449204
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88888286
20Ribosome_Homo sapiens_hsa030101.72629921
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56121022
22p53 signaling pathway_Homo sapiens_hsa041151.53081268
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45155851
24Oocyte meiosis_Homo sapiens_hsa041141.41676373
25Purine metabolism_Homo sapiens_hsa002301.36726160
26Propanoate metabolism_Homo sapiens_hsa006401.35302051
27Pyruvate metabolism_Homo sapiens_hsa006201.28568315
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27675753
29Steroid biosynthesis_Homo sapiens_hsa001001.27262090
30Selenocompound metabolism_Homo sapiens_hsa004501.18144602
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17511269
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17199091
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16378928
34Systemic lupus erythematosus_Homo sapiens_hsa053221.15582275
35Herpes simplex infection_Homo sapiens_hsa051681.08649215
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03705070
37Fatty acid elongation_Homo sapiens_hsa000620.98308158
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98182819
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97895666
40Carbon metabolism_Homo sapiens_hsa012000.97039785
41Viral carcinogenesis_Homo sapiens_hsa052030.94572996
42HTLV-I infection_Homo sapiens_hsa051660.92437266
43Folate biosynthesis_Homo sapiens_hsa007900.89352210
44Primary immunodeficiency_Homo sapiens_hsa053400.87352965
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86022392
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83849200
47Parkinsons disease_Homo sapiens_hsa050120.81598006
48MicroRNAs in cancer_Homo sapiens_hsa052060.79594362
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79211856
50Alcoholism_Homo sapiens_hsa050340.69266822
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67195688
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67167171
53Small cell lung cancer_Homo sapiens_hsa052220.63373435
54Colorectal cancer_Homo sapiens_hsa052100.62948209
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62629008
56Antigen processing and presentation_Homo sapiens_hsa046120.61049046
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59547571
58Oxidative phosphorylation_Homo sapiens_hsa001900.59394288
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.51312713
60Measles_Homo sapiens_hsa051620.51280270
61Hepatitis B_Homo sapiens_hsa051610.50883258
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49583378
63N-Glycan biosynthesis_Homo sapiens_hsa005100.47279174
64Glutathione metabolism_Homo sapiens_hsa004800.45729888
65Hematopoietic cell lineage_Homo sapiens_hsa046400.44213345
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43361789
67Thyroid cancer_Homo sapiens_hsa052160.42156060
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40137634
69Metabolic pathways_Homo sapiens_hsa011000.39242168
70Legionellosis_Homo sapiens_hsa051340.38066990
71Basal cell carcinoma_Homo sapiens_hsa052170.36220538
72Chronic myeloid leukemia_Homo sapiens_hsa052200.35110489
73Non-small cell lung cancer_Homo sapiens_hsa052230.33035371
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.32998143
75Pancreatic cancer_Homo sapiens_hsa052120.32466561
76Influenza A_Homo sapiens_hsa051640.32278589
77Apoptosis_Homo sapiens_hsa042100.32214727
78Fatty acid metabolism_Homo sapiens_hsa012120.31624901
79Pathways in cancer_Homo sapiens_hsa052000.31506641
80Hippo signaling pathway_Homo sapiens_hsa043900.31132963
81Protein export_Homo sapiens_hsa030600.31017250
82Pentose phosphate pathway_Homo sapiens_hsa000300.29500796
83Shigellosis_Homo sapiens_hsa051310.28586400
84Alzheimers disease_Homo sapiens_hsa050100.28583307
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28535913
86Notch signaling pathway_Homo sapiens_hsa043300.27595956
87Prostate cancer_Homo sapiens_hsa052150.27341692
88TGF-beta signaling pathway_Homo sapiens_hsa043500.26596942
89Wnt signaling pathway_Homo sapiens_hsa043100.25814790
90Sulfur relay system_Homo sapiens_hsa041220.24367268
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24186066
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22543161
93Viral myocarditis_Homo sapiens_hsa054160.22380816
94T cell receptor signaling pathway_Homo sapiens_hsa046600.22090423
95B cell receptor signaling pathway_Homo sapiens_hsa046620.22079224
96Hedgehog signaling pathway_Homo sapiens_hsa043400.21994026
97HIF-1 signaling pathway_Homo sapiens_hsa040660.21919248
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21674859
99Adherens junction_Homo sapiens_hsa045200.21038071
100Phototransduction_Homo sapiens_hsa047440.21000972
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.19619903
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18151836
103Peroxisome_Homo sapiens_hsa041460.17745330
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17628625
105Biosynthesis of amino acids_Homo sapiens_hsa012300.17355984
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.16549131
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16210093
108Autoimmune thyroid disease_Homo sapiens_hsa053200.15999715
109Melanoma_Homo sapiens_hsa052180.15196578
110Huntingtons disease_Homo sapiens_hsa050160.14732084
111FoxO signaling pathway_Homo sapiens_hsa040680.14723513
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14355416
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13406526
114Leishmaniasis_Homo sapiens_hsa051400.13191547
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12783573
116Glioma_Homo sapiens_hsa052140.10761014
117Allograft rejection_Homo sapiens_hsa053300.09674501
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.09364350
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.09290086
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.09260604
121Butanoate metabolism_Homo sapiens_hsa006500.08744555
122mTOR signaling pathway_Homo sapiens_hsa041500.08671843
123Vitamin B6 metabolism_Homo sapiens_hsa007500.07518452
124Lysine degradation_Homo sapiens_hsa003100.07342478
125Asthma_Homo sapiens_hsa053100.06913389
126beta-Alanine metabolism_Homo sapiens_hsa004100.06769188
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06703102
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06178217
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05736373
130Type I diabetes mellitus_Homo sapiens_hsa049400.05678465
131Endometrial cancer_Homo sapiens_hsa052130.05627253
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.05537363
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05351546
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05215920
135Arginine and proline metabolism_Homo sapiens_hsa003300.03887151
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02165524
137Olfactory transduction_Homo sapiens_hsa047400.01852568
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01567665
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0065185

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