CDCA4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.57565244
2cytidine metabolic process (GO:0046087)9.57565244
3cytidine catabolic process (GO:0006216)9.57565244
4pyrimidine ribonucleoside catabolic process (GO:0046133)9.14872330
5DNA deamination (GO:0045006)6.99701300
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.71961489
7opsonization (GO:0008228)5.80820807
8T cell migration (GO:0072678)5.50544041
9response to lead ion (GO:0010288)5.46983283
10protein K11-linked deubiquitination (GO:0035871)5.36164616
11regulation of interleukin-8 secretion (GO:2000482)4.98489024
12regulation of hexokinase activity (GO:1903299)4.88236894
13regulation of glucokinase activity (GO:0033131)4.88236894
14negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.27920799
15lymphocyte chemotaxis (GO:0048247)4.07966886
16pyrimidine nucleobase catabolic process (GO:0006208)3.98281455
17negative regulation of activin receptor signaling pathway (GO:0032926)3.81675789
18positive regulation of defense response to virus by host (GO:0002230)3.65842959
19DNA demethylation (GO:0080111)3.65742688
20negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.60789544
21branching involved in labyrinthine layer morphogenesis (GO:0060670)3.60120504
22startle response (GO:0001964)3.57735445
23chronic inflammatory response (GO:0002544)3.56863791
24peptidyl-cysteine modification (GO:0018198)3.56481985
25production of molecular mediator involved in inflammatory response (GO:0002532)3.55769008
26pyrimidine nucleoside catabolic process (GO:0046135)3.46468059
27ribonucleoprotein complex disassembly (GO:0032988)3.45965248
28establishment of mitochondrion localization (GO:0051654)3.43591529
29gamma-aminobutyric acid transport (GO:0015812)3.40139156
30negative regulation of T cell receptor signaling pathway (GO:0050860)3.39848203
31organelle disassembly (GO:1903008)3.37208437
32regulation of T cell receptor signaling pathway (GO:0050856)3.36610247
33seminiferous tubule development (GO:0072520)3.25972857
34nucleobase catabolic process (GO:0046113)3.22444671
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19571857
36histone mRNA catabolic process (GO:0071044)3.18053527
37regulation of energy homeostasis (GO:2000505)3.17420444
38positive regulation of vesicle fusion (GO:0031340)3.11244039
39histone H2A monoubiquitination (GO:0035518)3.10834163
40positive regulation of B cell differentiation (GO:0045579)3.07712454
41pyrimidine-containing compound catabolic process (GO:0072529)3.06170734
42negative regulation by host of viral transcription (GO:0043922)3.00856916
43DNA dealkylation (GO:0035510)3.00600359
44positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.99679654
45negative regulation of lipid storage (GO:0010888)2.97002419
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.95353683
47regulation of T-helper 1 cell differentiation (GO:0045625)2.95160760
48positive regulation of interleukin-1 beta secretion (GO:0050718)2.94706372
49photoreceptor cell maintenance (GO:0045494)2.94674540
50glycosphingolipid biosynthetic process (GO:0006688)2.94089290
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93666990
52mitochondrion transport along microtubule (GO:0047497)2.93666990
53regulation of B cell receptor signaling pathway (GO:0050855)2.92092653
54sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89146515
55neuronal action potential propagation (GO:0019227)2.89024943
56negative regulation of execution phase of apoptosis (GO:1900118)2.86935282
57acrosome assembly (GO:0001675)2.86845286
58positive regulation of T cell differentiation in thymus (GO:0033089)2.86492046
59positive regulation of interleukin-1 secretion (GO:0050716)2.85791734
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83611354
61membrane docking (GO:0022406)2.81860193
62regulation of viral genome replication (GO:0045069)2.81182553
63macrophage chemotaxis (GO:0048246)2.80241956
64lactate metabolic process (GO:0006089)2.76333042
65iron-sulfur cluster assembly (GO:0016226)2.71543403
66metallo-sulfur cluster assembly (GO:0031163)2.71543403
67histone H2A ubiquitination (GO:0033522)2.71173339
68proline transport (GO:0015824)2.70442492
69regulation of B cell differentiation (GO:0045577)2.68174777
70lymphocyte migration (GO:0072676)2.67947237
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66420892
72regulation of transforming growth factor beta1 production (GO:0032908)2.65913800
73acetyl-CoA metabolic process (GO:0006084)2.65500369
74regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.64499393
75negative regulation of viral genome replication (GO:0045071)2.63762488
76neural tube formation (GO:0001841)2.63316845
77regulation of interleukin-1 beta secretion (GO:0050706)2.62253238
78vocalization behavior (GO:0071625)2.60395280
79positive regulation of protein sumoylation (GO:0033235)2.60289180
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58936311
81modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.58784376
82positive regulation of fibroblast migration (GO:0010763)2.58449940
83succinate metabolic process (GO:0006105)2.56786173
84prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.56759675
85organ growth (GO:0035265)2.56675694
86regulation of lymphocyte chemotaxis (GO:1901623)2.56242493
87regulation of androgen receptor signaling pathway (GO:0060765)2.55749881
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54640479
89retinal cone cell development (GO:0046549)2.52529614
90detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.51027314
91L-serine transport (GO:0015825)2.50671315
92leukocyte tethering or rolling (GO:0050901)2.50544028
93ganglioside metabolic process (GO:0001573)2.47408108
94negative regulation of B cell proliferation (GO:0030889)2.47225719
95positive regulation of uterine smooth muscle contraction (GO:0070474)2.45509242
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44068379
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43772743
98regulation of chemokine-mediated signaling pathway (GO:0070099)2.43728601
99regulation of timing of cell differentiation (GO:0048505)2.41553103
100innervation (GO:0060384)2.41213874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human8.58475846
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.61523759
3FUS_26573619_Chip-Seq_HEK293_Human2.88233607
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74948749
5TAF15_26573619_Chip-Seq_HEK293_Human2.71437483
6GBX2_23144817_ChIP-Seq_PC3_Human2.67015764
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62591960
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49919270
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29158113
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26128652
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08585486
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.06533023
13P300_19829295_ChIP-Seq_ESCs_Human2.03189446
14ZNF274_21170338_ChIP-Seq_K562_Hela2.02141702
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.99582323
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94837809
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94318527
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92966386
19IGF1R_20145208_ChIP-Seq_DFB_Human1.92767965
20AR_21572438_ChIP-Seq_LNCaP_Human1.83367415
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.82354087
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79572923
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77063992
24CIITA_25753668_ChIP-Seq_RAJI_Human1.76469389
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76421989
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76386023
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72252984
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70713464
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66276680
30RUNX_20019798_ChIP-Seq_JUKART_Human1.62506247
31TP53_16413492_ChIP-PET_HCT116_Human1.62312853
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61710507
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55608318
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55413117
35IRF1_19129219_ChIP-ChIP_H3396_Human1.54257247
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.53923461
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51709797
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49796539
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49402443
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47457747
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.44097729
42SMAD4_21799915_ChIP-Seq_A2780_Human1.43750626
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39639510
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38015203
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.37261493
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.34404953
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32572263
48SMAD3_21741376_ChIP-Seq_HESCs_Human1.32500666
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28013199
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27675103
51RNF2_27304074_Chip-Seq_NSC_Mouse1.27249213
52MYB_26560356_Chip-Seq_TH2_Human1.25976508
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.24912250
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24664554
55CBP_20019798_ChIP-Seq_JUKART_Human1.24664554
56GATA3_26560356_Chip-Seq_TH2_Human1.21786343
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20565650
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.19031291
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.18610808
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.16660308
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16274767
62OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16041216
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.15580387
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.15130309
65STAT3_23295773_ChIP-Seq_U87_Human1.15077993
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14771540
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14587134
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14135659
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12987892
70BCAT_22108803_ChIP-Seq_LS180_Human1.11890585
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11461393
72SMAD4_21741376_ChIP-Seq_HESCs_Human1.09604034
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08959255
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08187233
75AR_25329375_ChIP-Seq_VCAP_Human1.07907006
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05929894
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.05773735
78TCF4_22108803_ChIP-Seq_LS180_Human1.04350772
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03975616
80P53_22387025_ChIP-Seq_ESCs_Mouse1.03798781
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.00142164
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99732456
83NMYC_18555785_Chip-Seq_ESCs_Mouse0.99163516
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98717543
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.98249794
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97626193
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97102444
88CTCF_18555785_Chip-Seq_ESCs_Mouse0.95766934
89P300_18555785_Chip-Seq_ESCs_Mouse0.94998014
90TCF4_23295773_ChIP-Seq_U87_Human0.94763009
91OCT4_18555785_Chip-Seq_ESCs_Mouse0.94621238
92ZFX_18555785_Chip-Seq_ESCs_Mouse0.94014359
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.93891207
94SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93499958
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.93497303
96RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93044724
97SOX2_21211035_ChIP-Seq_LN229_Gbm0.92099124
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92085685
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91879836
100TP53_18474530_ChIP-ChIP_U2OS_Human0.90251945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.57600618
2MP0005623_abnormal_meninges_morphology3.94345492
3MP0003880_abnormal_central_pattern3.68140828
4MP0008057_abnormal_DNA_replication3.03205283
5MP0002102_abnormal_ear_morphology3.00151836
6MP0005499_abnormal_olfactory_system2.78875486
7MP0005394_taste/olfaction_phenotype2.78875486
8MP0002138_abnormal_hepatobiliary_system2.68963610
9MP0001486_abnormal_startle_reflex2.62686021
10MP0005671_abnormal_response_to2.51109356
11MP0005423_abnormal_somatic_nervous2.34828313
12MP0002277_abnormal_respiratory_mucosa2.26263994
13MP0003045_fibrosis2.18689213
14MP0004043_abnormal_pH_regulation2.17428311
15MP0003329_amyloid_beta_deposits2.11662270
16MP0001984_abnormal_olfaction2.08450988
17MP0001986_abnormal_taste_sensitivity2.04222394
18MP0001529_abnormal_vocalization2.02264944
19MP0004147_increased_porphyrin_level2.02057884
20MP0006035_abnormal_mitochondrial_morpho1.89406263
21MP0008789_abnormal_olfactory_epithelium1.88109456
22MP0008004_abnormal_stomach_pH1.80500149
23MP0002736_abnormal_nociception_after1.78849951
24MP0004142_abnormal_muscle_tone1.73776875
25MP0009046_muscle_twitch1.71415543
26MP0004264_abnormal_extraembryonic_tissu1.71148249
27MP0003567_abnormal_fetal_cardiomyocyte1.65328052
28MP0000538_abnormal_urinary_bladder1.53876637
29MP0003890_abnormal_embryonic-extraembry1.53036459
30MP0005377_hearing/vestibular/ear_phenot1.49047744
31MP0003878_abnormal_ear_physiology1.49047744
32MP0001177_atelectasis1.47559659
33MP0003763_abnormal_thymus_physiology1.43663324
34MP0003252_abnormal_bile_duct1.40276118
35MP0000604_amyloidosis1.40068617
36MP0002876_abnormal_thyroid_physiology1.39762095
37MP0008260_abnormal_autophagy1.37873943
38MP0000778_abnormal_nervous_system1.31777161
39MP0003635_abnormal_synaptic_transmissio1.27948606
40MP0005253_abnormal_eye_physiology1.27282816
41MP0005000_abnormal_immune_tolerance1.23797936
42MP0002168_other_aberrant_phenotype1.21985105
43MP0001968_abnormal_touch/_nociception1.21564227
44MP0001270_distended_abdomen1.21137075
45MP0004924_abnormal_behavior1.19930512
46MP0005386_behavior/neurological_phenoty1.19930512
47MP0002653_abnormal_ependyma_morphology1.19609632
48MP0002127_abnormal_cardiovascular_syste1.18915535
49MP0009785_altered_susceptibility_to1.17669084
50MP0002254_reproductive_system_inflammat1.15287677
51MP0002132_abnormal_respiratory_system1.14046918
52MP0002396_abnormal_hematopoietic_system1.10571680
53MP0006082_CNS_inflammation1.05551268
54MP0001790_abnormal_immune_system1.05056369
55MP0005387_immune_system_phenotype1.05056369
56MP0002233_abnormal_nose_morphology1.04816003
57MP0002572_abnormal_emotion/affect_behav1.03564769
58MP0005551_abnormal_eye_electrophysiolog1.02176049
59MP0006036_abnormal_mitochondrial_physio1.01355115
60MP0006054_spinal_hemorrhage1.00921559
61MP0002184_abnormal_innervation1.00651676
62MP0001800_abnormal_humoral_immune0.95427718
63MP0002234_abnormal_pharynx_morphology0.93812253
64MP0001873_stomach_inflammation0.93219525
65MP0003195_calcinosis0.90796026
66MP0001485_abnormal_pinna_reflex0.90067168
67MP0002272_abnormal_nervous_system0.89054195
68MP0002751_abnormal_autonomic_nervous0.87677679
69MP0005025_abnormal_response_to0.86686942
70MP0003787_abnormal_imprinting0.85947468
71MP0006072_abnormal_retinal_apoptosis0.85682666
72MP0003221_abnormal_cardiomyocyte_apopto0.85125136
73MP0000427_abnormal_hair_cycle0.84772160
74MP0004270_analgesia0.83671970
75MP0002734_abnormal_mechanical_nocicepti0.82908549
76MP0002332_abnormal_exercise_endurance0.81245657
77MP0002398_abnormal_bone_marrow0.80600489
78MP0002064_seizures0.79867689
79MP0000647_abnormal_sebaceous_gland0.79042986
80MP0002928_abnormal_bile_duct0.79006155
81MP0002063_abnormal_learning/memory/cond0.78157080
82MP0002420_abnormal_adaptive_immunity0.77270979
83MP0004859_abnormal_synaptic_plasticity0.75813460
84MP0003436_decreased_susceptibility_to0.75056060
85MP0003137_abnormal_impulse_conducting0.74455851
86MP0000716_abnormal_immune_system0.73795663
87MP0002067_abnormal_sensory_capabilities0.73579515
88MP0001819_abnormal_immune_cell0.73120868
89MP0005195_abnormal_posterior_eye0.72478710
90MP0002723_abnormal_immune_serum0.72343177
91MP0001835_abnormal_antigen_presentation0.72058329
92MP0002405_respiratory_system_inflammati0.71388499
93MP0001440_abnormal_grooming_behavior0.69711382
94MP0003300_gastrointestinal_ulcer0.69452611
95MP0000569_abnormal_digit_pigmentation0.69439850
96MP0003632_abnormal_nervous_system0.68787570
97MP0004215_abnormal_myocardial_fiber0.68246169
98MP0009745_abnormal_behavioral_response0.66124212
99MP0000689_abnormal_spleen_morphology0.65868820
100MP0002752_abnormal_somatic_nervous0.65822041

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)6.74034938
2Amyotrophic lateral sclerosis (HP:0007354)6.04787485
3Decreased lacrimation (HP:0000633)4.28995437
4Inability to walk (HP:0002540)4.21191816
5Volvulus (HP:0002580)3.73756013
6Panhypogammaglobulinemia (HP:0003139)3.73510892
7Abnormality of alanine metabolism (HP:0010916)3.51186571
8Hyperalaninemia (HP:0003348)3.51186571
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.51186571
10Stomatitis (HP:0010280)3.32004924
11Atrophy/Degeneration involving motor neurons (HP:0007373)3.10363370
12Alacrima (HP:0000522)3.08923490
13Stomach cancer (HP:0012126)3.08697540
14Agnosia (HP:0010524)2.96852857
15Abnormality of the labia minora (HP:0012880)2.94655698
16Autoimmune hemolytic anemia (HP:0001890)2.90901673
17Abnormal auditory evoked potentials (HP:0006958)2.87630635
18Dry hair (HP:0011359)2.84229707
19Basal cell carcinoma (HP:0002671)2.82018628
20Cutaneous melanoma (HP:0012056)2.67241703
21Broad alveolar ridges (HP:0000187)2.65278708
22Optic nerve coloboma (HP:0000588)2.65195369
23Tetraparesis (HP:0002273)2.63494597
24Thyroiditis (HP:0100646)2.53317847
25Agammaglobulinemia (HP:0004432)2.50276424
26Congenital malformation of the right heart (HP:0011723)2.49891809
27Double outlet right ventricle (HP:0001719)2.49891809
28Heterotopia (HP:0002282)2.48868500
29Epiphyseal stippling (HP:0010655)2.48414330
30Abnormality of serum amino acid levels (HP:0003112)2.45857355
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.43674987
32Chronic hepatic failure (HP:0100626)2.42842215
33Intestinal atresia (HP:0011100)2.40464554
34Severe combined immunodeficiency (HP:0004430)2.39661527
35Glioma (HP:0009733)2.38175367
36Occipital encephalocele (HP:0002085)2.38020840
373-Methylglutaconic aciduria (HP:0003535)2.33521262
38Abnormality of B cell number (HP:0010975)2.31944846
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29170084
40Poor speech (HP:0002465)2.29051979
41Broad-based gait (HP:0002136)2.27322479
42Spastic diplegia (HP:0001264)2.23570174
43Chronic otitis media (HP:0000389)2.20369210
44Intellectual disability, moderate (HP:0002342)2.19342839
45Facial diplegia (HP:0001349)2.19075719
46Shawl scrotum (HP:0000049)2.19020199
47Medulloblastoma (HP:0002885)2.17159878
48Hypoplasia of the thymus (HP:0000778)2.16701490
49Atonic seizures (HP:0010819)2.16222106
50B lymphocytopenia (HP:0010976)2.15832898
51Exotropia (HP:0000577)2.12964955
52Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12582393
53Lissencephaly (HP:0001339)2.10348619
54Menstrual irregularities (HP:0000858)2.05381858
55Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99862518
56Febrile seizures (HP:0002373)1.97477673
57Trigonocephaly (HP:0000243)1.95775655
58Constricted visual fields (HP:0001133)1.95526563
59Severe Myopia (HP:0011003)1.93648848
60Intention tremor (HP:0002080)1.93427199
61Poikiloderma (HP:0001029)1.92550072
62Hypsarrhythmia (HP:0002521)1.91605815
63Combined immunodeficiency (HP:0005387)1.91298085
64Posterior subcapsular cataract (HP:0007787)1.90259870
65Generalized myoclonic seizures (HP:0002123)1.89211811
66Gastroesophageal reflux (HP:0002020)1.88469124
67Urinary bladder sphincter dysfunction (HP:0002839)1.85838011
68Hypoplastic pelvis (HP:0008839)1.85659802
69Abnormality of the astrocytes (HP:0100707)1.84995303
70Astrocytoma (HP:0009592)1.84995303
71Nephrogenic diabetes insipidus (HP:0009806)1.84965077
72Renal hypoplasia (HP:0000089)1.82822916
73EEG with generalized epileptiform discharges (HP:0011198)1.81597370
74Rectal prolapse (HP:0002035)1.80674512
75Epileptiform EEG discharges (HP:0011182)1.78280813
76Limb dystonia (HP:0002451)1.76700422
77Abnormality of DNA repair (HP:0003254)1.75923778
78Colon cancer (HP:0003003)1.75545857
79Aqueductal stenosis (HP:0002410)1.74547608
80Recurrent sinusitis (HP:0011108)1.72207503
81Chin dimple (HP:0010751)1.70722530
82Abnormality of the alveolar ridges (HP:0006477)1.70533112
83Abnormality of vision evoked potentials (HP:0000649)1.69602863
84Neoplasm of the oral cavity (HP:0100649)1.69082397
85Entropion (HP:0000621)1.67564300
86Urinary urgency (HP:0000012)1.67354838
87Widely spaced teeth (HP:0000687)1.66668900
88Ileus (HP:0002595)1.66662122
89Lower limb amyotrophy (HP:0007210)1.66647876
90Brushfield spots (HP:0001088)1.66274202
91Medial flaring of the eyebrow (HP:0010747)1.66112550
92Lower limb muscle weakness (HP:0007340)1.64590844
93Overlapping toe (HP:0001845)1.62981577
94Abnormality of the motor neurons (HP:0002450)1.62088275
95Abnormal neuron morphology (HP:0012757)1.62088275
96Epileptic encephalopathy (HP:0200134)1.58551323
97Esophageal atresia (HP:0002032)1.58093399
98Mild short stature (HP:0003502)1.58088972
99Central scotoma (HP:0000603)1.57569697
100Attenuation of retinal blood vessels (HP:0007843)1.57296323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.78684860
2LMTK24.74287916
3PDK23.66126391
4TNIK3.30869676
5ZAK3.25140792
6PBK2.78747766
7FGFR22.57719049
8MAP3K122.43100736
9BLK2.27984984
10TESK22.15840730
11ERBB41.93541034
12CAMK1G1.83901824
13CLK11.76388968
14PNCK1.75414994
15NLK1.60919777
16KDR1.60855179
17STK38L1.60587832
18WNK31.55301182
19MAP2K71.55279597
20MAP3K51.49126914
21MAP3K41.48532994
22TXK1.48444837
23NTRK21.43901200
24BMPR1B1.34651678
25PIK3CA1.33558198
26EIF2AK31.32058864
27MAP4K11.27388326
28BCR1.23897079
29NEK91.19620177
30MAPK131.15414287
31MARK11.14411195
32DAPK11.12130750
33PRKCG1.10113347
34SYK1.05590024
35FGFR11.04980389
36ACVR1B1.04309270
37MKNK11.04303542
38NEK10.97636475
39INSRR0.97476606
40DAPK20.93632530
41MAP2K40.89986233
42MAP3K110.89418221
43PINK10.88898154
44FRK0.88789033
45PRKCQ0.87830525
46PRKD30.87813027
47SRPK10.85477383
48MAPKAPK30.83398111
49GRK10.80558400
50NTRK30.79711140
51CAMK1D0.75392549
52PRKCE0.73924662
53ATR0.73802081
54FGR0.72246298
55JAK30.71659475
56BCKDK0.71062854
57RIPK40.65948707
58MAP3K70.64981115
59LYN0.64299421
60PAK30.63404631
61MST40.62931232
62AKT30.62276337
63PASK0.62272276
64ITK0.61997736
65DYRK1A0.61993769
66OXSR10.54965685
67ALK0.54467472
68MAP3K100.53411860
69LCK0.52117136
70BTK0.51983039
71OBSCN0.50946281
72ERBB30.50487603
73FYN0.49424455
74TEC0.47622798
75SCYL20.46629435
76CDK30.45211436
77MARK20.44804554
78CAMK10.44041369
79CSNK1D0.43094432
80DYRK20.42660964
81TIE10.42113920
82STK390.41687246
83IGF1R0.38866461
84SIK30.37543245
85ZAP700.37445692
86EGFR0.37190564
87CDC70.36231853
88MAP3K140.34947056
89STK110.34491049
90STK160.33305830
91TGFBR10.32713596
92PRKG20.32534708
93ABL10.31905950
94PDGFRA0.31080913
95FGFR30.30502355
96PRKCA0.30477959
97UHMK10.30085357
98PDK10.27519209
99CDK50.26884413
100PRKCH0.26123529

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.44065816
2Primary immunodeficiency_Homo sapiens_hsa053403.82620689
3Antigen processing and presentation_Homo sapiens_hsa046123.43607176
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.86999015
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.81322224
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30744559
7Steroid biosynthesis_Homo sapiens_hsa001002.20460906
8Olfactory transduction_Homo sapiens_hsa047402.19793924
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.94113962
10Butanoate metabolism_Homo sapiens_hsa006501.92250414
11Propanoate metabolism_Homo sapiens_hsa006401.88671247
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.84617581
13Taste transduction_Homo sapiens_hsa047421.79578339
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73722525
15Allograft rejection_Homo sapiens_hsa053301.66874922
16Nicotine addiction_Homo sapiens_hsa050331.66700459
17Type I diabetes mellitus_Homo sapiens_hsa049401.58462675
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55347336
19Rheumatoid arthritis_Homo sapiens_hsa053231.42760539
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.37078407
21Ether lipid metabolism_Homo sapiens_hsa005651.32292438
22Proteasome_Homo sapiens_hsa030501.24539873
23Autoimmune thyroid disease_Homo sapiens_hsa053201.21800801
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16026227
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15964145
26GABAergic synapse_Homo sapiens_hsa047271.13103116
27T cell receptor signaling pathway_Homo sapiens_hsa046601.12443512
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05161259
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00314875
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97148876
31Viral myocarditis_Homo sapiens_hsa054160.91218860
32Non-homologous end-joining_Homo sapiens_hsa034500.86990117
33African trypanosomiasis_Homo sapiens_hsa051430.84645373
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83254537
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82269655
36TNF signaling pathway_Homo sapiens_hsa046680.81958999
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80714353
38Hepatitis C_Homo sapiens_hsa051600.80227278
39Pyruvate metabolism_Homo sapiens_hsa006200.78515455
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76727837
41Colorectal cancer_Homo sapiens_hsa052100.75980873
42Osteoclast differentiation_Homo sapiens_hsa043800.75171973
43Asthma_Homo sapiens_hsa053100.72802536
44Morphine addiction_Homo sapiens_hsa050320.72634791
45beta-Alanine metabolism_Homo sapiens_hsa004100.71028680
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.69237685
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69094900
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66197230
49Basal transcription factors_Homo sapiens_hsa030220.65401991
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64492800
51Calcium signaling pathway_Homo sapiens_hsa040200.63349426
52Measles_Homo sapiens_hsa051620.63318658
53Dopaminergic synapse_Homo sapiens_hsa047280.63295708
54Peroxisome_Homo sapiens_hsa041460.61924645
55Synaptic vesicle cycle_Homo sapiens_hsa047210.61760356
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61334864
57TGF-beta signaling pathway_Homo sapiens_hsa043500.58727708
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57383773
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57011752
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55484058
61Base excision repair_Homo sapiens_hsa034100.54739705
62Salivary secretion_Homo sapiens_hsa049700.53885922
63Lysine degradation_Homo sapiens_hsa003100.53267440
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52860866
65Selenocompound metabolism_Homo sapiens_hsa004500.52760334
66Inositol phosphate metabolism_Homo sapiens_hsa005620.52373733
67Vibrio cholerae infection_Homo sapiens_hsa051100.52122497
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51158407
69Gastric acid secretion_Homo sapiens_hsa049710.50923145
70RNA degradation_Homo sapiens_hsa030180.50084800
71Vitamin B6 metabolism_Homo sapiens_hsa007500.48346053
72Apoptosis_Homo sapiens_hsa042100.46228741
73ABC transporters_Homo sapiens_hsa020100.46152121
74Chemokine signaling pathway_Homo sapiens_hsa040620.45664804
75Shigellosis_Homo sapiens_hsa051310.45071354
76Salmonella infection_Homo sapiens_hsa051320.44977599
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44306176
78Hematopoietic cell lineage_Homo sapiens_hsa046400.42921686
79Malaria_Homo sapiens_hsa051440.42167480
80Herpes simplex infection_Homo sapiens_hsa051680.42106156
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42041583
82Regulation of autophagy_Homo sapiens_hsa041400.42041029
83Long-term depression_Homo sapiens_hsa047300.41771027
84Glutamatergic synapse_Homo sapiens_hsa047240.41697601
85Fanconi anemia pathway_Homo sapiens_hsa034600.40486543
86Tuberculosis_Homo sapiens_hsa051520.39548666
87Endocytosis_Homo sapiens_hsa041440.38929085
88HIF-1 signaling pathway_Homo sapiens_hsa040660.38077145
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38056668
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.36157954
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35717274
92Axon guidance_Homo sapiens_hsa043600.35288007
93B cell receptor signaling pathway_Homo sapiens_hsa046620.34365558
94Amphetamine addiction_Homo sapiens_hsa050310.32975124
95Nitrogen metabolism_Homo sapiens_hsa009100.31466029
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29993122
97Non-small cell lung cancer_Homo sapiens_hsa052230.29389561
98Circadian rhythm_Homo sapiens_hsa047100.29121570
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26986745
100Type II diabetes mellitus_Homo sapiens_hsa049300.25920684

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