CDCA4P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter transport (GO:0051589)8.67416027
2signal peptide processing (GO:0006465)6.72124126
3cellular zinc ion homeostasis (GO:0006882)6.52004562
4DNA integration (GO:0015074)6.50256685
5regulation of histone H3-K27 methylation (GO:0061085)5.80523018
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.77360545
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.77360545
8nuclear pore organization (GO:0006999)5.27455658
9histone H3-K4 trimethylation (GO:0080182)5.16862733
10zinc ion homeostasis (GO:0055069)5.05668192
11protein targeting to lysosome (GO:0006622)5.02843696
12establishment of protein localization to vacuole (GO:0072666)5.02843696
13protein targeting to vacuole (GO:0006623)5.02843696
14zinc ion transmembrane transport (GO:0071577)4.97317030
15anterior/posterior axis specification, embryo (GO:0008595)4.61059841
16positive regulation of granulocyte differentiation (GO:0030854)4.54126480
17establishment of protein localization to Golgi (GO:0072600)4.53571272
18germinal center formation (GO:0002467)4.47654960
19protein targeting to Golgi (GO:0000042)4.35989394
20regulation of Rac protein signal transduction (GO:0035020)4.30388703
21regulation of translational fidelity (GO:0006450)4.25449119
22retrograde transport, vesicle recycling within Golgi (GO:0000301)4.22517230
23polyol transport (GO:0015791)4.14740051
24sulfate transmembrane transport (GO:1902358)4.13670012
25UV protection (GO:0009650)4.07024130
26production of molecular mediator involved in inflammatory response (GO:0002532)4.06066372
27positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.02685081
28energy homeostasis (GO:0097009)3.87752165
29peptidyl-lysine trimethylation (GO:0018023)3.60133945
30phasic smooth muscle contraction (GO:0014821)3.59761407
31Golgi to endosome transport (GO:0006895)3.54404775
32regulation of relaxation of muscle (GO:1901077)3.50352436
33purine ribonucleotide transport (GO:0015868)3.48656825
34sulfate transport (GO:0008272)3.47278500
35protein kinase C signaling (GO:0070528)3.45748623
36transepithelial transport (GO:0070633)3.40014277
37protein localization to Golgi apparatus (GO:0034067)3.33421685
38endothelial cell chemotaxis (GO:0035767)3.29569284
39adenine nucleotide transport (GO:0051503)3.29144220
40regulation of gamma-delta T cell differentiation (GO:0045586)3.29118829
41negative regulation of T cell receptor signaling pathway (GO:0050860)3.27443882
42positive regulation of tolerance induction (GO:0002645)3.22777804
43intra-Golgi vesicle-mediated transport (GO:0006891)3.20274936
44regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.19364112
45iron ion import (GO:0097286)3.16157578
46nuclear pore complex assembly (GO:0051292)3.15960508
47response to lipoprotein particle (GO:0055094)3.14683137
48protein localization to vacuole (GO:0072665)3.14298601
49protein localization to lysosome (GO:0061462)3.14298601
50positive regulation of T cell chemotaxis (GO:0010820)3.10082400
51regulation of T cell chemotaxis (GO:0010819)3.10082400
52regulation of DNA damage checkpoint (GO:2000001)3.00072760
53regulation of centrosome duplication (GO:0010824)2.99616727
54histone H4-K16 acetylation (GO:0043984)2.99352549
55negative regulation of Rho protein signal transduction (GO:0035024)2.97450134
56peptidyl-histidine modification (GO:0018202)2.97415318
57monoubiquitinated protein deubiquitination (GO:0035520)2.96623440
58detection of molecule of bacterial origin (GO:0032490)2.95752553
59negative regulation of complement activation (GO:0045916)2.93536584
60cellular response to dsRNA (GO:0071359)2.92352042
61phagocytosis, recognition (GO:0006910)2.91884393
62negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.90434469
63Golgi to plasma membrane protein transport (GO:0043001)2.89012138
64wound healing, spreading of epidermal cells (GO:0035313)2.83928095
65regulation of MHC class I biosynthetic process (GO:0045343)2.83518732
66histone H3-K4 methylation (GO:0051568)2.79879252
67termination of RNA polymerase II transcription (GO:0006369)2.77663828
68regulation of gamma-delta T cell activation (GO:0046643)2.76454044
69inositol phosphate-mediated signaling (GO:0048016)2.75974447
70negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75876557
71response to UV-C (GO:0010225)2.73647392
72macrophage activation (GO:0042116)2.72270408
73respiratory tube development (GO:0030323)2.69440890
74response to xenobiotic stimulus (GO:0009410)2.67338919
75regulation of glycolytic process (GO:0006110)2.66310664
76regulation of granulocyte differentiation (GO:0030852)2.65550844
77regulation of T cell tolerance induction (GO:0002664)2.65122330
78rRNA methylation (GO:0031167)2.64972170
79detection of light stimulus involved in sensory perception (GO:0050962)2.64850440
80detection of light stimulus involved in visual perception (GO:0050908)2.64850440
81mannose metabolic process (GO:0006013)2.64422175
82regulation of endothelial cell chemotaxis (GO:2001026)2.64345447
83neuron maturation (GO:0042551)2.61341123
84auditory receptor cell stereocilium organization (GO:0060088)2.60768261
85negative regulation of mRNA metabolic process (GO:1903312)2.60495278
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.60247735
87T-helper cell differentiation (GO:0042093)2.60247735
88negative regulation of macrophage differentiation (GO:0045650)2.59868457
89C21-steroid hormone biosynthetic process (GO:0006700)2.58754680
90sperm capacitation (GO:0048240)2.56867703
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56840747
92regulation of mRNA catabolic process (GO:0061013)2.56274916
93negative regulation of protein activation cascade (GO:2000258)2.52484139
94positive regulation of DNA-templated transcription, initiation (GO:2000144)2.51127224
95negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.49898079
96pore complex assembly (GO:0046931)2.46823563
97metaphase plate congression (GO:0051310)2.45452796
98response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.45120797
99regulation of mRNA splicing, via spliceosome (GO:0048024)2.44573358
100negative regulation of neurotransmitter secretion (GO:0046929)11.2313559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse7.78865469
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.19536286
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.88663824
4GATA1_22025678_ChIP-Seq_K562_Human2.85413431
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.15714002
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04336695
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.6405140
8RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99671654
9CIITA_25753668_ChIP-Seq_RAJI_Human1.81372759
10EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79798836
11IGF1R_20145208_ChIP-Seq_DFB_Human1.78082857
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66587677
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45949242
14CHD1_26751641_Chip-Seq_LNCaP_Human1.43886491
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43094398
16MYB_26560356_Chip-Seq_TH1_Human1.33331479
17PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31956612
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.29107631
19NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27000169
20MAF_26560356_Chip-Seq_TH1_Human1.25678803
21ELK1_19687146_ChIP-ChIP_HELA_Human1.25495201
22AHR_22903824_ChIP-Seq_MCF-7_Human1.24369872
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.24239805
24MYB_26560356_Chip-Seq_TH2_Human1.18470352
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18274513
26TP53_16413492_ChIP-PET_HCT116_Human1.17822365
27GATA3_26560356_Chip-Seq_TH2_Human1.17078467
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16414659
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16414659
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.14425857
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11796386
32GATA3_27048872_Chip-Seq_THYMUS_Human1.10471355
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.07930209
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06820274
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.06755714
36SCL_19346495_ChIP-Seq_HPC-7_Human1.04548153
37FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04470589
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03015572
39EWS_26573619_Chip-Seq_HEK293_Human1.02557964
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.02491466
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99194512
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98639243
43PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97135062
44VDR_23849224_ChIP-Seq_CD4+_Human0.93116970
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92090317
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89725897
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89137822
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88706218
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88116016
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87706883
51KDM5A_27292631_Chip-Seq_BREAST_Human0.87166967
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86299941
53HNFA_21074721_ChIP-Seq_CACO-2_Human0.86164022
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85805764
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85805764
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85161226
57EST1_17652178_ChIP-ChIP_JURKAT_Human0.85056912
58MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84619621
59TBL1_22424771_ChIP-Seq_293T_Human0.84333670
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82902659
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82624350
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81765711
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81049784
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80407015
65GABP_17652178_ChIP-ChIP_JURKAT_Human0.78773331
66FOXO3_23340844_ChIP-Seq_DLD1_Human0.78524031
67GATA1_19941827_ChIP-Seq_MEL_Mouse0.78201221
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.77925732
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77782955
70E2F4_17652178_ChIP-ChIP_JURKAT_Human0.76977274
71NFYB_21822215_ChIP-Seq_K562_Human0.76172287
72GATA3_26560356_Chip-Seq_TH1_Human0.76156972
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75246748
74ETV1_20927104_ChIP-Seq_GIST48_Human0.75029050
75ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73234900
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72704066
77CBP_20019798_ChIP-Seq_JUKART_Human0.72294338
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72294338
79VDR_24787735_ChIP-Seq_THP-1_Human0.71945313
80FOXP3_21729870_ChIP-Seq_TREG_Human0.71813991
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70991307
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70787376
83RBPJ_21746931_ChIP-Seq_IB4_Human0.70076620
84TFEB_21752829_ChIP-Seq_HELA_Human0.69597373
85CDX2_22108803_ChIP-Seq_LS180_Human0.68924692
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.68741113
87GATA1_19941826_ChIP-Seq_K562_Human0.68260376
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.68101997
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68056984
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.67924947
91NFYA_21822215_ChIP-Seq_K562_Human0.67772855
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67114934
93MAF_26560356_Chip-Seq_TH2_Human0.66215475
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.66124241
95PHF8_20622853_ChIP-Seq_HELA_Human0.65934965
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65886869
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65293827
98ER_23166858_ChIP-Seq_MCF-7_Human0.64076180
99E2F7_22180533_ChIP-Seq_HELA_Human0.63883750
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63765219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.78576878
2MP0002009_preneoplasia5.72340968
3MP0000569_abnormal_digit_pigmentation4.20114394
4MP0002653_abnormal_ependyma_morphology3.90406944
5MP0002166_altered_tumor_susceptibility3.55564130
6MP0008057_abnormal_DNA_replication3.18096207
7MP0004036_abnormal_muscle_relaxation3.15271662
8MP0002254_reproductive_system_inflammat3.01709770
9MP0010352_gastrointestinal_tract_polyps2.93308162
10MP0004264_abnormal_extraembryonic_tissu2.64545567
11MP0002837_dystrophic_cardiac_calcinosis2.63762529
12MP0000538_abnormal_urinary_bladder2.53608731
13MP0002006_tumorigenesis2.38502668
14MP0000537_abnormal_urethra_morphology2.37792781
15MP0004145_abnormal_muscle_electrophysio2.33241066
16MP0003045_fibrosis2.08936860
17MP0001502_abnormal_circadian_rhythm1.97359336
18MP0002138_abnormal_hepatobiliary_system1.91004778
19MP0004381_abnormal_hair_follicle1.88315069
20MP0005167_abnormal_blood-brain_barrier1.86957841
21MP0002132_abnormal_respiratory_system1.81635144
22MP0005083_abnormal_biliary_tract1.80175816
23MP0008877_abnormal_DNA_methylation1.66720029
24MP0003315_abnormal_perineum_morphology1.64363689
25MP0003724_increased_susceptibility_to1.58200169
26MP0004510_myositis1.51557292
27MP0005501_abnormal_skin_physiology1.47564902
28MP0004084_abnormal_cardiac_muscle1.47267574
29MP0003828_pulmonary_edema1.45644677
30MP0002396_abnormal_hematopoietic_system1.43654990
31MP0004130_abnormal_muscle_cell1.42834328
32MP0003787_abnormal_imprinting1.33103471
33MP0002796_impaired_skin_barrier1.32630650
34MP0005075_abnormal_melanosome_morpholog1.31912035
35MP0008995_early_reproductive_senescence1.30115749
36MP0000015_abnormal_ear_pigmentation1.30028798
37MP0003172_abnormal_lysosome_physiology1.29274907
38MP0005085_abnormal_gallbladder_physiolo1.28798847
39MP0003123_paternal_imprinting1.26285324
40MP0008438_abnormal_cutaneous_collagen1.25843938
41MP0005408_hypopigmentation1.24968352
42MP0005377_hearing/vestibular/ear_phenot1.22567314
43MP0003878_abnormal_ear_physiology1.22567314
44MP0002090_abnormal_vision1.21504928
45MP0004147_increased_porphyrin_level1.20336788
46MP0004233_abnormal_muscle_weight1.19478046
47MP0003252_abnormal_bile_duct1.17813880
48MP0000371_diluted_coat_color1.16190279
49MP0003279_aneurysm1.15044140
50MP0000383_abnormal_hair_follicle1.14463349
51MP0008875_abnormal_xenobiotic_pharmacok1.10013346
52MP0001835_abnormal_antigen_presentation1.02781110
53MP0003866_abnormal_defecation1.02596033
54MP0002405_respiratory_system_inflammati0.96407100
55MP0008873_increased_physiological_sensi0.96077235
56MP0000689_abnormal_spleen_morphology0.95911997
57MP0001188_hyperpigmentation0.94939404
58MP0009764_decreased_sensitivity_to0.93491305
59MP0003763_abnormal_thymus_physiology0.92823396
60MP0001191_abnormal_skin_condition0.91100080
61MP0003786_premature_aging0.88250173
62MP0001270_distended_abdomen0.86335408
63MP0005174_abnormal_tail_pigmentation0.85229646
64MP0001919_abnormal_reproductive_system0.82077317
65MP0009697_abnormal_copulation0.81202823
66MP0005671_abnormal_response_to0.80446337
67MP0002638_abnormal_pupillary_reflex0.79203912
68MP0001800_abnormal_humoral_immune0.78307151
69MP0003011_delayed_dark_adaptation0.78061648
70MP0000703_abnormal_thymus_morphology0.75014605
71MP0010155_abnormal_intestine_physiology0.70925707
72MP0001853_heart_inflammation0.70549941
73MP0005410_abnormal_fertilization0.69469983
74MP0005365_abnormal_bile_salt0.69101124
75MP0002295_abnormal_pulmonary_circulatio0.69078698
76MP0005670_abnormal_white_adipose0.68875270
77MP0005647_abnormal_sex_gland0.67413852
78MP0000609_abnormal_liver_physiology0.66989610
79MP0004134_abnormal_chest_morphology0.66789755
80MP0000598_abnormal_liver_morphology0.66246223
81MP0004043_abnormal_pH_regulation0.64619528
82MP0001845_abnormal_inflammatory_respons0.63894240
83MP0005076_abnormal_cell_differentiation0.63687629
84MP0010771_integument_phenotype0.63452608
85MP0002722_abnormal_immune_system0.63443619
86MP0002136_abnormal_kidney_physiology0.62742097
87MP0002135_abnormal_kidney_morphology0.61905817
88MP0000470_abnormal_stomach_morphology0.61800152
89MP0004883_abnormal_blood_vessel0.60513070
90MP0002019_abnormal_tumor_incidence0.59822125
91MP0002420_abnormal_adaptive_immunity0.58377285
92MP0005000_abnormal_immune_tolerance0.57709791
93MP0002933_joint_inflammation0.57268253
94MP0008775_abnormal_heart_ventricle0.56930014
95MP0005310_abnormal_salivary_gland0.56272145
96MP0002168_other_aberrant_phenotype0.53844209
97MP0000647_abnormal_sebaceous_gland0.53074128
98MP0010386_abnormal_urinary_bladder0.52575298
99MP0009643_abnormal_urine_homeostasis0.52455940
100MP0002452_abnormal_antigen_presenting0.52260998

Predicted human phenotypes

RankGene SetZ-score
1Abnormal spermatogenesis (HP:0008669)7.82670414
2Prostate neoplasm (HP:0100787)6.09929702
3Testicular atrophy (HP:0000029)5.47766913
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.87581553
5Calf muscle hypertrophy (HP:0008981)4.84448112
6Abnormality of DNA repair (HP:0003254)4.67015595
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.51252835
8Long palpebral fissure (HP:0000637)4.36778579
9Muscle hypertrophy of the lower extremities (HP:0008968)4.30954800
10Clumsiness (HP:0002312)3.98900463
11Gonadotropin excess (HP:0000837)3.83531827
12Increased cerebral lipofuscin (HP:0011813)3.75091087
13Poor eye contact (HP:0000817)3.59785830
14Abnormality of the axillary hair (HP:0100134)3.58255627
15Abnormality of secondary sexual hair (HP:0009888)3.58255627
16Long eyelashes (HP:0000527)3.46071429
17Abnormality of the prostate (HP:0008775)3.39033223
18Tubular atrophy (HP:0000092)3.14842314
19Elevated erythrocyte sedimentation rate (HP:0003565)3.13533534
20Horizontal nystagmus (HP:0000666)3.00855403
21Bile duct proliferation (HP:0001408)2.91528990
22Abnormal biliary tract physiology (HP:0012439)2.91528990
23Polydipsia (HP:0001959)2.90174716
24Abnormal drinking behavior (HP:0030082)2.90174716
25Esotropia (HP:0000565)2.76311071
26Gaze-evoked nystagmus (HP:0000640)2.71512428
27Potter facies (HP:0002009)2.67467107
28Facial shape deformation (HP:0011334)2.67467107
29Nuclear cataract (HP:0100018)2.58311200
30Pancreatic fibrosis (HP:0100732)2.57240239
31Hyperkalemia (HP:0002153)2.49586796
32Aortic valve stenosis (HP:0001650)2.46453623
33Abnormality of the renal cortex (HP:0011035)2.42151522
34Testicular neoplasm (HP:0010788)2.41762034
35Impaired social interactions (HP:0000735)2.40723520
36Abnormal social behavior (HP:0012433)2.40723520
37Stomatitis (HP:0010280)2.38459382
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.35217289
39Prominent metopic ridge (HP:0005487)2.33264362
40Bulbar palsy (HP:0001283)2.33148288
41Acute myeloid leukemia (HP:0004808)2.33002074
42Thin upper lip vermilion (HP:0000219)2.27814458
43Pancreatic cysts (HP:0001737)2.25104808
44Generalized hypopigmentation of hair (HP:0011358)2.25097343
45Fair hair (HP:0002286)2.24456357
46Enlarged kidneys (HP:0000105)2.22714827
47Hyperinsulinemic hypoglycemia (HP:0000825)2.22506221
48Abnormality of the calf musculature (HP:0001430)2.19170496
49Neoplasm of the tracheobronchial system (HP:0100552)2.18482171
50Cerebral aneurysm (HP:0004944)2.15553512
51Homocystinuria (HP:0002156)2.15223704
52Abnormality of homocysteine metabolism (HP:0010919)2.15223704
53Reduced subcutaneous adipose tissue (HP:0003758)2.14772378
54Microcytic anemia (HP:0001935)2.14709429
55Ectropion (HP:0000656)2.08623448
56Lip pit (HP:0100267)2.08473821
57Abnormality of male internal genitalia (HP:0000022)2.07441610
58Infertility (HP:0000789)2.06193839
59Asplenia (HP:0001746)2.05611505
60Supernumerary spleens (HP:0009799)2.05503285
61Entropion (HP:0000621)2.04938956
62Depressed nasal tip (HP:0000437)2.03961779
63Gastrointestinal infarctions (HP:0005244)2.03310899
64Hypochromic microcytic anemia (HP:0004840)2.01569453
65Alveolar cell carcinoma (HP:0006519)2.00459531
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00259185
67Azoospermia (HP:0000027)10.1879288
68Hypoplasia of the pons (HP:0012110)1.97088462
69Bulbous nose (HP:0000414)1.94644531
70Abnormality of the metopic suture (HP:0005556)1.93249205
71J-shaped sella turcica (HP:0002680)1.93156225
72Erythema (HP:0010783)1.90340037
73Decreased circulating renin level (HP:0003351)1.86987130
74Nonimmune hydrops fetalis (HP:0001790)1.86363663
75Bifid scrotum (HP:0000048)1.85776654
76Hypothermia (HP:0002045)1.85696559
77Increased CSF protein (HP:0002922)1.85542385
78Hypokalemic alkalosis (HP:0001949)1.84452608
79Submucous cleft hard palate (HP:0000176)1.83872275
80Polyuria (HP:0000103)1.83491746
81Intention tremor (HP:0002080)1.83345556
82Bicuspid aortic valve (HP:0001647)1.79269847
83Highly arched eyebrow (HP:0002553)1.79156236
84Progressive microcephaly (HP:0000253)1.78763185
85Dysmetric saccades (HP:0000641)1.77718389
86Facial diplegia (HP:0001349)1.76440587
87Orchitis (HP:0100796)1.76066515
88Broad face (HP:0000283)1.73343890
89CNS hypomyelination (HP:0003429)1.72484360
90Progressive visual loss (HP:0000529)1.69230926
91Abnormality of the pons (HP:0007361)1.68919437
92Myocardial infarction (HP:0001658)1.68511680
93IgA deficiency (HP:0002720)1.68306699
94Prominent nose (HP:0000448)1.67470894
95Neonatal hypoglycemia (HP:0001998)1.67248207
96Deformed sella turcica (HP:0002681)1.65470625
97Chromsome breakage (HP:0040012)1.65007631
98Abnormality of the renal medulla (HP:0100957)1.63489587
99Abnormality of the fingertips (HP:0001211)1.63120940
100Short chin (HP:0000331)1.62012510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK26.71419966
2ZAK3.98210301
3AKT33.56354095
4IRAK23.16874462
5TLK13.06632085
6FER2.75831108
7BRSK22.56359034
8FRK2.53586613
9PDK22.45199594
10MAPK132.33319644
11ERN11.93300367
12BRD41.85231920
13BMPR21.74751772
14TAOK11.74161483
15IRAK11.72597219
16MAP3K101.68537141
17MAPKAPK31.68216860
18TAOK31.67149207
19TRPM71.61218839
20DYRK1B1.40136550
21EPHA31.33744004
22TEC1.32546738
23ACVR1B1.31999942
24MST41.22352440
25ABL21.19500565
26RPS6KA51.18648180
27CAMK11.15093792
28TYK21.13985363
29IKBKB1.13857294
30DAPK21.12378912
31PIM21.10520661
32MAP2K61.05057477
33PDK11.03726988
34PDPK11.02587312
35STK38L0.99115683
36TGFBR20.98087212
37SIK20.88805096
38RPS6KA40.87648504
39SGK20.83907862
40CAMK40.83240902
41PKN10.82547176
42MAP3K70.81831529
43PRKAA10.81159188
44VRK10.79441253
45ICK0.78781973
46PIK3CG0.78758569
47PIM10.78147403
48NEK20.77371868
49CDK120.76420413
50ITK0.74164278
51WNK10.72640111
52BTK0.70919200
53SIK30.67444308
54SGK30.65895467
55FES0.65478243
56BRSK10.64708496
57DYRK1A0.64478669
58STK40.64223420
59MARK30.63322630
60IKBKE0.62547232
61PRKCQ0.62221883
62GSK3A0.62155052
63STK30.61591800
64PRKCZ0.60040027
65MST1R0.59823005
66MARK20.58619960
67EEF2K0.57723276
68CAMK2G0.57387970
69MAPK110.54539151
70PRKAA20.53245013
71NTRK30.50650200
72CHUK0.50133205
73MTOR0.49660269
74MAPK80.49268088
75CAMKK20.49107498
76CHEK10.46196868
77RAF10.44963118
78CDK30.44376301
79STK110.42877402
80HCK0.40430928
81YES10.40324839
82AKT10.39444301
83CDK70.38764562
84SGK10.37847983
85CAMK2D0.36738585
86PRKG20.35846436
87PDGFRB0.35690374
88PAK30.35227033
89MAP3K140.34953087
90PTK2B0.34541321
91TSSK60.33008801
92GSK3B0.32836005
93MAPK10.32275778
94AURKA0.31413651
95EPHA40.31318788
96CDK90.31223528
97JAK10.30850847
98WEE10.30748948
99SGK2230.30580691
100SGK4940.30580691

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.82542505
2Systemic lupus erythematosus_Homo sapiens_hsa053223.35754881
3Lysine degradation_Homo sapiens_hsa003103.30126503
4Nitrogen metabolism_Homo sapiens_hsa009103.23624069
5Regulation of autophagy_Homo sapiens_hsa041403.18611373
6Alcoholism_Homo sapiens_hsa050342.55517155
7Circadian rhythm_Homo sapiens_hsa047102.21179585
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05683069
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.05075341
10mRNA surveillance pathway_Homo sapiens_hsa030151.96171982
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.89204720
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79611980
13FoxO signaling pathway_Homo sapiens_hsa040681.75869685
14Insulin resistance_Homo sapiens_hsa049311.74549344
15Dorso-ventral axis formation_Homo sapiens_hsa043201.58648880
16ABC transporters_Homo sapiens_hsa020101.50251855
17Longevity regulating pathway - mammal_Homo sapiens_hsa042111.44028123
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43104589
19Primary immunodeficiency_Homo sapiens_hsa053401.39929135
20Measles_Homo sapiens_hsa051621.39189324
21Notch signaling pathway_Homo sapiens_hsa043301.37668518
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32804468
23T cell receptor signaling pathway_Homo sapiens_hsa046601.32035290
24RNA transport_Homo sapiens_hsa030131.30281577
25ErbB signaling pathway_Homo sapiens_hsa040121.28951882
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26990502
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26778989
28Viral carcinogenesis_Homo sapiens_hsa052031.22209009
29mTOR signaling pathway_Homo sapiens_hsa041501.19875234
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.19831030
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.15401466
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11521209
33Tryptophan metabolism_Homo sapiens_hsa003801.01506431
34Propanoate metabolism_Homo sapiens_hsa006401.00583867
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99048630
36Caffeine metabolism_Homo sapiens_hsa002320.95171810
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91119240
38Bladder cancer_Homo sapiens_hsa052190.91051921
39Insulin secretion_Homo sapiens_hsa049110.88155048
40Glucagon signaling pathway_Homo sapiens_hsa049220.87979700
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86401353
42Chronic myeloid leukemia_Homo sapiens_hsa052200.86274076
43Prostate cancer_Homo sapiens_hsa052150.83556229
44HIF-1 signaling pathway_Homo sapiens_hsa040660.79386983
45Olfactory transduction_Homo sapiens_hsa047400.79097392
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79057154
47TNF signaling pathway_Homo sapiens_hsa046680.76583437
48MicroRNAs in cancer_Homo sapiens_hsa052060.76363116
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.75007015
50AMPK signaling pathway_Homo sapiens_hsa041520.72909209
51Antigen processing and presentation_Homo sapiens_hsa046120.71079219
52Sphingolipid metabolism_Homo sapiens_hsa006000.69355823
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.68508761
54Retinol metabolism_Homo sapiens_hsa008300.64783111
55Insulin signaling pathway_Homo sapiens_hsa049100.64484162
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62181580
57Taste transduction_Homo sapiens_hsa047420.60273077
58Prolactin signaling pathway_Homo sapiens_hsa049170.59632359
59Estrogen signaling pathway_Homo sapiens_hsa049150.58346524
60Nucleotide excision repair_Homo sapiens_hsa034200.56683588
61p53 signaling pathway_Homo sapiens_hsa041150.55158449
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55006365
63Ovarian steroidogenesis_Homo sapiens_hsa049130.54398679
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53007610
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52617388
66Osteoclast differentiation_Homo sapiens_hsa043800.50966190
67Arginine biosynthesis_Homo sapiens_hsa002200.50707218
68Hepatitis B_Homo sapiens_hsa051610.50159888
69Salivary secretion_Homo sapiens_hsa049700.49766554
70TGF-beta signaling pathway_Homo sapiens_hsa043500.47809692
71Herpes simplex infection_Homo sapiens_hsa051680.45091488
72Type II diabetes mellitus_Homo sapiens_hsa049300.44315363
73RNA polymerase_Homo sapiens_hsa030200.44177326
74Oocyte meiosis_Homo sapiens_hsa041140.43536209
75Butanoate metabolism_Homo sapiens_hsa006500.43521633
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43061326
77Glioma_Homo sapiens_hsa052140.42131786
78Peroxisome_Homo sapiens_hsa041460.41737507
79MAPK signaling pathway_Homo sapiens_hsa040100.41433914
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.41209135
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40936312
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38467427
83Other glycan degradation_Homo sapiens_hsa005110.37199537
84Fanconi anemia pathway_Homo sapiens_hsa034600.36852445
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35386171
86Tuberculosis_Homo sapiens_hsa051520.35229293
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34274115
88HTLV-I infection_Homo sapiens_hsa051660.33658151
89Acute myeloid leukemia_Homo sapiens_hsa052210.33285414
90Toxoplasmosis_Homo sapiens_hsa051450.32890137
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32475460
92Inositol phosphate metabolism_Homo sapiens_hsa005620.32282292
93Bile secretion_Homo sapiens_hsa049760.31762427
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30689785
95Amphetamine addiction_Homo sapiens_hsa050310.30545682
96Hepatitis C_Homo sapiens_hsa051600.30500383
97PPAR signaling pathway_Homo sapiens_hsa033200.30192898
98Spliceosome_Homo sapiens_hsa030400.30037273
99Non-small cell lung cancer_Homo sapiens_hsa052230.29721494
100cAMP signaling pathway_Homo sapiens_hsa040240.27810935

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