CDCA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.41812937
2DNA strand elongation involved in DNA replication (GO:0006271)5.95257779
3DNA strand elongation (GO:0022616)5.69952432
4DNA replication initiation (GO:0006270)5.47157613
5telomere maintenance via semi-conservative replication (GO:0032201)5.40644766
6ribosomal small subunit assembly (GO:0000028)5.06483571
7telomere maintenance via recombination (GO:0000722)4.72896441
8mitotic recombination (GO:0006312)4.60553160
9DNA replication checkpoint (GO:0000076)4.56600451
10protein localization to kinetochore (GO:0034501)4.40141265
11nucleobase biosynthetic process (GO:0046112)4.28927239
12telomere maintenance via telomere lengthening (GO:0010833)4.26614120
13maturation of SSU-rRNA (GO:0030490)4.20458499
14mitotic sister chromatid cohesion (GO:0007064)4.17332671
15nucleotide-excision repair, DNA gap filling (GO:0006297)4.15734889
16IMP biosynthetic process (GO:0006188)4.15605849
17viral transcription (GO:0019083)4.12284484
18translational termination (GO:0006415)4.02261297
19DNA ligation (GO:0006266)3.97972084
20DNA deamination (GO:0045006)3.96970630
21DNA replication-dependent nucleosome assembly (GO:0006335)3.93379062
22DNA replication-dependent nucleosome organization (GO:0034723)3.93379062
23purine nucleobase biosynthetic process (GO:0009113)3.90338208
24DNA duplex unwinding (GO:0032508)3.84491638
25formation of translation preinitiation complex (GO:0001731)3.83495639
26folic acid-containing compound biosynthetic process (GO:0009396)3.83494577
27DNA geometric change (GO:0032392)3.81239330
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79695475
29IMP metabolic process (GO:0046040)3.79477456
30chromatin remodeling at centromere (GO:0031055)3.79093411
31CENP-A containing nucleosome assembly (GO:0034080)3.77805724
32non-recombinational repair (GO:0000726)3.76622768
33double-strand break repair via nonhomologous end joining (GO:0006303)3.76622768
34protein localization to chromosome, centromeric region (GO:0071459)3.76088049
35translational elongation (GO:0006414)3.70392906
36mitotic nuclear envelope disassembly (GO:0007077)3.67346957
37pore complex assembly (GO:0046931)3.62730153
38ribosomal small subunit biogenesis (GO:0042274)3.61600453
39ribosomal large subunit biogenesis (GO:0042273)3.60651129
40mitotic metaphase plate congression (GO:0007080)3.59419214
41DNA replication-independent nucleosome organization (GO:0034724)3.56775741
42DNA replication-independent nucleosome assembly (GO:0006336)3.56775741
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49008423
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49007080
45translational initiation (GO:0006413)3.48276434
46mitotic chromosome condensation (GO:0007076)3.46086728
47negative regulation of mRNA metabolic process (GO:1903312)3.45887292
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45579895
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.45579895
50translesion synthesis (GO:0019985)3.44472027
51establishment of integrated proviral latency (GO:0075713)3.44402918
52heterochromatin organization (GO:0070828)3.41799312
53kinetochore organization (GO:0051383)3.41200280
54DNA synthesis involved in DNA repair (GO:0000731)3.41185491
55regulation of centriole replication (GO:0046599)3.40975709
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39444030
57ribonucleoprotein complex biogenesis (GO:0022613)3.38140957
58negative regulation of RNA splicing (GO:0033119)3.36774956
59membrane disassembly (GO:0030397)3.36422322
60nuclear envelope disassembly (GO:0051081)3.36422322
61replication fork processing (GO:0031297)3.34878225
62telomere maintenance (GO:0000723)3.33938668
63telomere organization (GO:0032200)3.33010022
64regulation of sister chromatid cohesion (GO:0007063)3.32781056
65DNA double-strand break processing (GO:0000729)3.31978822
66nuclear pore organization (GO:0006999)3.30945681
67mismatch repair (GO:0006298)3.30917569
68metaphase plate congression (GO:0051310)3.30222074
69cotranslational protein targeting to membrane (GO:0006613)3.29551385
70protein targeting to ER (GO:0045047)3.28126934
71ribosome assembly (GO:0042255)3.27884653
72ribosome biogenesis (GO:0042254)3.25797269
73ATP-dependent chromatin remodeling (GO:0043044)3.25704078
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25170900
75DNA strand renaturation (GO:0000733)3.25004234
76intra-S DNA damage checkpoint (GO:0031573)3.22656147
77mitotic sister chromatid segregation (GO:0000070)3.22270907
78establishment of viral latency (GO:0019043)3.21585843
79V(D)J recombination (GO:0033151)3.20813462
80DNA catabolic process, exonucleolytic (GO:0000738)3.20632289
81DNA conformation change (GO:0071103)3.17362811
82negative regulation of chromosome segregation (GO:0051985)3.16716700
83viral mRNA export from host cell nucleus (GO:0046784)3.16589382
84cellular protein complex disassembly (GO:0043624)3.15156537
85chromosome segregation (GO:0007059)3.13386394
86spliceosomal snRNP assembly (GO:0000387)3.13133961
87pseudouridine synthesis (GO:0001522)3.13062141
88attachment of spindle microtubules to kinetochore (GO:0008608)3.12650640
89viral life cycle (GO:0019058)3.12372502
90rRNA processing (GO:0006364)3.11715286
91histone exchange (GO:0043486)3.11501826
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10402090
93transcription-coupled nucleotide-excision repair (GO:0006283)3.09918952
94somatic cell DNA recombination (GO:0016444)3.08795962
95somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.08795962
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.08654325
97negative regulation of sister chromatid segregation (GO:0033046)3.08654325
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08654325
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08654325
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08654325
101sister chromatid segregation (GO:0000819)3.08381918
102base-excision repair (GO:0006284)3.07284368
103DNA topological change (GO:0006265)3.07259383
104positive regulation of chromosome segregation (GO:0051984)3.07236775
105postreplication repair (GO:0006301)3.07203667
106protein localization to endoplasmic reticulum (GO:0070972)3.06061569
107regulation of nuclear cell cycle DNA replication (GO:0033262)3.04985180
108chromatin assembly or disassembly (GO:0006333)3.03962714
109nuclear pore complex assembly (GO:0051292)3.02629920
110regulation of chromosome segregation (GO:0051983)3.02394499
111rRNA metabolic process (GO:0016072)3.02374861
112regulation of histone H3-K9 methylation (GO:0051570)3.01464378
113mitotic spindle checkpoint (GO:0071174)3.01320870
114regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01070390
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01070390
116spindle checkpoint (GO:0031577)2.99886369
117regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99801496
118negative regulation of mRNA processing (GO:0050686)2.99747095
119establishment of chromosome localization (GO:0051303)2.99634827
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.98686883
121kinetochore assembly (GO:0051382)2.98339743
122regulation of translational fidelity (GO:0006450)2.98145797
123regulation of helicase activity (GO:0051095)2.97961398
124protein complex disassembly (GO:0043241)2.97532015
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95990759
126nuclear-transcribed mRNA catabolic process (GO:0000956)2.94633932
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93772776
128mRNA splicing, via spliceosome (GO:0000398)2.93772776
129RNA splicing, via transesterification reactions (GO:0000375)2.91966012
130termination of RNA polymerase II transcription (GO:0006369)2.91506761
131meiotic chromosome segregation (GO:0045132)2.90605391
132DNA replication (GO:0006260)2.90076091
133cell cycle G1/S phase transition (GO:0044843)2.89079053
134G1/S transition of mitotic cell cycle (GO:0000082)2.89079053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_18555785_ChIP-Seq_MESCs_Mouse4.18003996
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96731322
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.93417034
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70597587
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20571684
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88504905
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77021558
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72751536
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72017650
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65244288
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42057830
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.39443193
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.37326026
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34971258
15XRN2_22483619_ChIP-Seq_HELA_Human2.29983163
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25926375
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.17945750
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17626266
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.15473683
20AR_21909140_ChIP-Seq_LNCAP_Human2.12799009
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10019017
22VDR_23849224_ChIP-Seq_CD4+_Human2.04281307
23* E2F7_22180533_ChIP-Seq_HELA_Human10.6293145
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99999800
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99875687
26MYC_22102868_ChIP-Seq_BL_Human1.97657434
27FOXP3_21729870_ChIP-Seq_TREG_Human1.96423743
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92582715
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89824979
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86038510
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85757445
32CIITA_25753668_ChIP-Seq_RAJI_Human1.84862194
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81971156
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79842898
35DCP1A_22483619_ChIP-Seq_HELA_Human1.78838066
36TTF2_22483619_ChIP-Seq_HELA_Human1.75438841
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74170355
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70054410
39GABP_19822575_ChIP-Seq_HepG2_Human1.69765303
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65086298
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60816274
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60190856
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56750438
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56046894
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52341444
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52096266
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51215220
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49170551
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45556841
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42037015
51ELK1_19687146_ChIP-ChIP_HELA_Human1.41210618
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40969628
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39545510
54VDR_21846776_ChIP-Seq_THP-1_Human1.38982781
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.38402009
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38262531
57KDM5A_27292631_Chip-Seq_BREAST_Human1.35756697
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33320443
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32356235
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32265717
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24615182
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20594269
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.20221748
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13039685
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11144560
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.09521841
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09326558
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08822633
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08734788
70* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08267092
71* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07478184
72* SALL1_21062744_ChIP-ChIP_HESCs_Human1.05638154
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05488834
74SPI1_23547873_ChIP-Seq_NB4_Human1.05017573
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04714678
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03713183
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02755428
78TFEB_21752829_ChIP-Seq_HELA_Human1.02741731
79MYC_18940864_ChIP-ChIP_HL60_Human1.02306409
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00453808
81* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00450740
82SCL_19346495_ChIP-Seq_HPC-7_Human1.00406385
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99915362
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99912129
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97519377
86* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96080321
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88092646
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87665690
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84880357
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84511735
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84332283
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83776924
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83467771
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83191937
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82374155
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.81534115
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81346913
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80479635
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.79106135
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77947037
101* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77504000
102* UTX_26944678_Chip-Seq_JUKART_Human0.76309459
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.75603011
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75119968
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74903068
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73919278
107* MYB_26560356_Chip-Seq_TH2_Human0.73378166
108* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72227874
109* SOX17_20123909_ChIP-Seq_XEN_Mouse0.71669992
110ZNF263_19887448_ChIP-Seq_K562_Human0.69971715
111EWS_26573619_Chip-Seq_HEK293_Human0.67301914
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.65623321
113IRF1_19129219_ChIP-ChIP_H3396_Human0.65081530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.29539340
2MP0003693_abnormal_embryo_hatching4.94632409
3MP0003111_abnormal_nucleus_morphology4.39640546
4MP0008057_abnormal_DNA_replication4.33487056
5MP0004957_abnormal_blastocyst_morpholog4.10591743
6MP0003077_abnormal_cell_cycle3.95356195
7MP0002396_abnormal_hematopoietic_system3.48345273
8MP0008058_abnormal_DNA_repair3.47923979
9MP0008007_abnormal_cellular_replicative2.99933256
10MP0009697_abnormal_copulation2.80555704
11MP0010352_gastrointestinal_tract_polyps2.44946708
12MP0008932_abnormal_embryonic_tissue2.36680846
13MP0003123_paternal_imprinting2.30364403
14MP0000490_abnormal_crypts_of2.29057459
15MP0000350_abnormal_cell_proliferation2.19626106
16MP0001730_embryonic_growth_arrest2.11555456
17MP0004808_abnormal_hematopoietic_stem2.06595488
18MP0008877_abnormal_DNA_methylation1.99315687
19MP0010307_abnormal_tumor_latency1.79099411
20MP0003763_abnormal_thymus_physiology1.72234555
21MP0003786_premature_aging1.68978909
22MP0002019_abnormal_tumor_incidence1.65343773
23MP0005397_hematopoietic_system_phenotyp1.62576278
24MP0001545_abnormal_hematopoietic_system1.62576278
25MP0001672_abnormal_embryogenesis/_devel1.57237672
26MP0005380_embryogenesis_phenotype1.57237672
27MP0001697_abnormal_embryo_size1.55485027
28MP0000313_abnormal_cell_death1.54990837
29MP0006054_spinal_hemorrhage1.52311815
30MP0002009_preneoplasia1.50928698
31MP0002080_prenatal_lethality1.50870042
32MP0000703_abnormal_thymus_morphology1.47948993
33MP0002398_abnormal_bone_marrow1.46538021
34MP0005075_abnormal_melanosome_morpholog1.44258867
35MP0003984_embryonic_growth_retardation1.42535556
36MP0005174_abnormal_tail_pigmentation1.38858143
37MP0002088_abnormal_embryonic_growth/wei1.38170558
38MP0009333_abnormal_splenocyte_physiolog1.35697849
39MP0002085_abnormal_embryonic_tissue1.35294938
40MP0002722_abnormal_immune_system1.33405920
41MP0003567_abnormal_fetal_cardiomyocyte1.33237375
42MP0003121_genomic_imprinting1.30023550
43MP0009278_abnormal_bone_marrow1.29382220
44MP0000689_abnormal_spleen_morphology1.27112995
45MP0002084_abnormal_developmental_patter1.26750253
46MP0006292_abnormal_olfactory_placode1.25854956
47MP0002086_abnormal_extraembryonic_tissu1.25105666
48MP0004197_abnormal_fetal_growth/weight/1.21577555
49MP0006035_abnormal_mitochondrial_morpho1.20606784
50MP0004185_abnormal_adipocyte_glucose1.14993057
51MP0001293_anophthalmia1.12806649
52MP0002429_abnormal_blood_cell1.12569075
53MP0010030_abnormal_orbit_morphology1.10393253
54MP0006036_abnormal_mitochondrial_physio1.06998724
55MP0002210_abnormal_sex_determination1.05971668
56MP0000537_abnormal_urethra_morphology1.03970187
57MP0003941_abnormal_skin_development1.01884015
58MP0000716_abnormal_immune_system1.00988741
59MP0003937_abnormal_limbs/digits/tail_de0.99916124
60MP0002095_abnormal_skin_pigmentation0.99877159
61MP0003315_abnormal_perineum_morphology0.98210396
62MP0009379_abnormal_foot_pigmentation0.96205091
63MP0001145_abnormal_male_reproductive0.96121291
64MP0002132_abnormal_respiratory_system0.95183682
65MP0008995_early_reproductive_senescence0.93596744
66MP0003890_abnormal_embryonic-extraembry0.91794310
67MP0000858_altered_metastatic_potential0.91681896
68MP0005076_abnormal_cell_differentiation0.91424175
69MP0001286_abnormal_eye_development0.89752616
70MP0001853_heart_inflammation0.86414122
71MP0000566_synostosis0.84743431
72MP0001346_abnormal_lacrimal_gland0.83377339
73MP0001188_hyperpigmentation0.82804639
74MP0000477_abnormal_intestine_morphology0.82508927
75MP0010155_abnormal_intestine_physiology0.82275783
76MP0001835_abnormal_antigen_presentation0.81751040
77MP0001929_abnormal_gametogenesis0.81042093
78MP0000465_gastrointestinal_hemorrhage0.80081125
79MP0002420_abnormal_adaptive_immunity0.79967743
80MP0002166_altered_tumor_susceptibility0.79733337
81MP0000653_abnormal_sex_gland0.79375237
82MP0001800_abnormal_humoral_immune0.78641971
83MP0002075_abnormal_coat/hair_pigmentati0.78088900
84MP0001819_abnormal_immune_cell0.77822247
85MP0005501_abnormal_skin_physiology0.77175871
86MP0000685_abnormal_immune_system0.76241808
87MP0002697_abnormal_eye_size0.75179333
88MP0003221_abnormal_cardiomyocyte_apopto0.75122484
89MP0000358_abnormal_cell_content/0.74965153
90MP0002006_tumorigenesis0.74739191
91MP0009672_abnormal_birth_weight0.73075362
92MP0003718_maternal_effect0.73056655
93MP0001764_abnormal_homeostasis0.72044939
94MP0002938_white_spotting0.71125760
95MP0003806_abnormal_nucleotide_metabolis0.71013218
96MP0001915_intracranial_hemorrhage0.70777304
97MP0001119_abnormal_female_reproductive0.70634532
98MP0003943_abnormal_hepatobiliary_system0.70066832
99MP0005671_abnormal_response_to0.69513832
100MP0003698_abnormal_male_reproductive0.69233440
101MP0002452_abnormal_antigen_presenting0.68895516
102MP0002405_respiratory_system_inflammati0.68598166
103MP0005384_cellular_phenotype0.67169965
104MP0004264_abnormal_extraembryonic_tissu0.66308676
105MP0002111_abnormal_tail_morphology0.65886554
106MP0001873_stomach_inflammation0.65245991
107MP0004147_increased_porphyrin_level0.64637844
108MP0000372_irregular_coat_pigmentation0.63317255
109MP0002092_abnormal_eye_morphology0.62878957
110MP0003699_abnormal_female_reproductive0.62380600
111MP0002877_abnormal_melanocyte_morpholog0.60790205
112MP0003385_abnormal_body_wall0.60408070
113MP0000049_abnormal_middle_ear0.59844845
114MP0002160_abnormal_reproductive_system0.59579480
115MP0006072_abnormal_retinal_apoptosis0.59376286
116MP0003186_abnormal_redox_activity0.59237619
117MP0002723_abnormal_immune_serum0.59092981
118MP0003119_abnormal_digestive_system0.58395035
119MP0005621_abnormal_cell_physiology0.58257223
120MP0005025_abnormal_response_to0.57493073
121MP0009703_decreased_birth_body0.57070268
122MP0002234_abnormal_pharynx_morphology0.56924278
123MP0001529_abnormal_vocalization0.56229807
124MP0001177_atelectasis0.55374770
125MP0002161_abnormal_fertility/fecundity0.55354126
126MP0002796_impaired_skin_barrier0.54829812
127MP0003861_abnormal_nervous_system0.54342910
128MP0001881_abnormal_mammary_gland0.53636400
129MP0008770_decreased_survivor_rate0.53339822
130MP0002233_abnormal_nose_morphology0.53228145

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.81232396
2Birth length less than 3rd percentile (HP:0003561)4.57513378
3Abnormality of cells of the erythroid lineage (HP:0012130)4.45226627
4Abnormal number of erythroid precursors (HP:0012131)4.35877197
5Colon cancer (HP:0003003)4.14045508
6Chromsome breakage (HP:0040012)4.04597489
7Aplastic anemia (HP:0001915)3.88167741
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76148757
9Medulloblastoma (HP:0002885)3.70363001
10Oral leukoplakia (HP:0002745)3.70325667
11Ependymoma (HP:0002888)3.47571430
12Abnormality of chromosome stability (HP:0003220)3.33541193
13Selective tooth agenesis (HP:0001592)3.27271427
14Microvesicular hepatic steatosis (HP:0001414)3.17759695
15Agnosia (HP:0010524)3.17545508
16Abnormality of the preputium (HP:0100587)3.16772226
17Thrombocytosis (HP:0001894)3.11851432
18Myelodysplasia (HP:0002863)3.05455842
19Multiple enchondromatosis (HP:0005701)3.01734254
20Meckel diverticulum (HP:0002245)2.99949003
21Pallor (HP:0000980)2.95410324
22Abnormality of the ileum (HP:0001549)2.95291453
23Macrocytic anemia (HP:0001972)2.90462568
24Abnormality of the labia minora (HP:0012880)2.89785982
25Patellar aplasia (HP:0006443)2.83534212
26Embryonal renal neoplasm (HP:0011794)2.80206322
27Absent thumb (HP:0009777)2.78100656
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.76795649
29Breast hypoplasia (HP:0003187)2.75478470
3011 pairs of ribs (HP:0000878)2.74951888
31Rhabdomyosarcoma (HP:0002859)2.73325763
32IgM deficiency (HP:0002850)2.69575153
33Abnormality of cochlea (HP:0000375)2.69563222
34Abnormal number of incisors (HP:0011064)2.69561071
35Aplasia/Hypoplasia of the patella (HP:0006498)2.63395471
36Abnormality of the anterior horn cell (HP:0006802)2.62235365
37Degeneration of anterior horn cells (HP:0002398)2.62235365
38Basal cell carcinoma (HP:0002671)2.60207530
39Bone marrow hypocellularity (HP:0005528)2.56086851
40Neoplasm of the pancreas (HP:0002894)2.55717693
41Premature graying of hair (HP:0002216)2.52046251
42Small intestinal stenosis (HP:0012848)2.51111206
43Duodenal stenosis (HP:0100867)2.51111206
44Rough bone trabeculation (HP:0100670)2.43692198
45Increased nuchal translucency (HP:0010880)2.43639964
46Absent forearm bone (HP:0003953)2.40486605
47Aplasia involving forearm bones (HP:0009822)2.40486605
48Lymphoma (HP:0002665)2.39727477
49Volvulus (HP:0002580)2.39649917
50Amaurosis fugax (HP:0100576)2.38391801
51Microretrognathia (HP:0000308)2.33009350
52Combined immunodeficiency (HP:0005387)2.30370399
53Horseshoe kidney (HP:0000085)2.29939345
54Abnormal lung lobation (HP:0002101)2.25219752
55Cellular immunodeficiency (HP:0005374)2.25124091
56Ectopic kidney (HP:0000086)2.24867539
57Pancytopenia (HP:0001876)2.23466300
58Abnormality of the carotid arteries (HP:0005344)2.22314460
59Tracheoesophageal fistula (HP:0002575)2.21988514
60Abnormality of B cell number (HP:0010975)2.15735157
61B lymphocytopenia (HP:0010976)2.15735157
62Abnormality of glycolysis (HP:0004366)2.14651301
63Sloping forehead (HP:0000340)2.14543204
64Acute lymphatic leukemia (HP:0006721)2.14028266
65Neoplasm of the colon (HP:0100273)2.13993961
66Panhypogammaglobulinemia (HP:0003139)2.13965016
67Proximal placement of thumb (HP:0009623)2.11893616
68Poikiloderma (HP:0001029)2.11523471
69Embryonal neoplasm (HP:0002898)2.11228527
70Abnormality of DNA repair (HP:0003254)2.08173815
71Neoplasm of striated muscle (HP:0009728)2.08134567
72Atresia of the external auditory canal (HP:0000413)2.05593366
73Choanal atresia (HP:0000453)2.04785452
74Abnormality of the duodenum (HP:0002246)2.04593827
75Astrocytoma (HP:0009592)2.04436096
76Abnormality of the astrocytes (HP:0100707)2.04436096
77Neoplasm of the oral cavity (HP:0100649)2.04435949
78Duplicated collecting system (HP:0000081)2.04157047
79Morphological abnormality of the inner ear (HP:0011390)2.03121504
80Increased serum pyruvate (HP:0003542)2.02143217
81Progressive muscle weakness (HP:0003323)1.97680071
82Triphalangeal thumb (HP:0001199)1.97440777
83Severe combined immunodeficiency (HP:0004430)1.97410817
84Slender long bone (HP:0003100)1.97364269
85Overlapping toe (HP:0001845)1.97015017
86Duplication of thumb phalanx (HP:0009942)1.96243086
87High pitched voice (HP:0001620)1.96181113
88Type I transferrin isoform profile (HP:0003642)1.95505838
89Arteriovenous malformation (HP:0100026)1.94788258
90Squamous cell carcinoma (HP:0002860)1.94509423
91Carpal bone hypoplasia (HP:0001498)1.94425228
92Deviation of the thumb (HP:0009603)1.94354526
93Clubbing of toes (HP:0100760)1.93874381
94Megaloblastic anemia (HP:0001889)1.93006748
95Impulsivity (HP:0100710)1.92888396
96Nephroblastoma (Wilms tumor) (HP:0002667)1.92695204
97Asplenia (HP:0001746)1.92327142
98Cafe-au-lait spot (HP:0000957)1.89569316
99Prominent nose (HP:0000448)1.89538085
100Glossoptosis (HP:0000162)1.88742764
101Pancreatic islet-cell hyperplasia (HP:0004510)1.88262534
102Glioma (HP:0009733)1.87364737
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87034307
104Cortical dysplasia (HP:0002539)1.86321033
105Cerebral hypomyelination (HP:0006808)1.85610019
106Short middle phalanx of the 5th finger (HP:0004220)1.84813954
107Missing ribs (HP:0000921)1.83035907
108Broad alveolar ridges (HP:0000187)1.82144019
109Aplasia/Hypoplasia of the thymus (HP:0010515)1.81497999
110Absent radius (HP:0003974)1.79543583
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.79318403
112Abnormality of the renal collecting system (HP:0004742)1.79081551
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.78927787
114Acute myeloid leukemia (HP:0004808)1.78794887
115Trismus (HP:0000211)1.78514351
116Abnormality of T cells (HP:0002843)1.78485623
117Neoplasm of the adrenal gland (HP:0100631)1.78211565
118Irregular epiphyses (HP:0010582)1.77999654
119Recurrent viral infections (HP:0004429)1.77351278
120Neoplasm of the adrenal cortex (HP:0100641)1.77124126
121Short thumb (HP:0009778)1.76755303
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76464018
123Short 4th metacarpal (HP:0010044)1.76464018
124Optic nerve coloboma (HP:0000588)1.75710659
125Neoplasm of the rectum (HP:0100743)1.75627797
126Abnormality of reticulocytes (HP:0004312)1.75333686
127Lipid accumulation in hepatocytes (HP:0006561)1.75319378
128Cleft eyelid (HP:0000625)1.72940550
129Abnormality of methionine metabolism (HP:0010901)1.72920360
130Abnormality of pyrimidine metabolism (HP:0004353)1.72248640
131Premature ovarian failure (HP:0008209)1.69590354
132Increased hepatocellular lipid droplets (HP:0006565)1.67319503
133Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66195233
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65977388
135Abnormality of chromosome segregation (HP:0002916)1.64230903
136Agammaglobulinemia (HP:0004432)1.62237000
137Acute encephalopathy (HP:0006846)1.61214201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.16193950
2WEE14.74331999
3VRK23.68447966
4BUB13.61228782
5PBK2.70447886
6NEK22.52709448
7EIF2AK12.51877106
8SRPK12.38464686
9EEF2K2.29089742
10TTK2.15991701
11NUAK12.13196611
12ACVR1B2.12895143
13BRSK22.11252119
14PASK2.07819932
15TSSK62.02653305
16MKNK12.01545612
17ATR2.00565281
18RPS6KB22.00110123
19CDK71.99522725
20VRK11.98592417
21TAF11.96706433
22SMG11.86531133
23STK161.80301998
24TLK11.79644995
25PLK11.76339816
26MAP3K101.75093908
27DYRK31.67763355
28STK101.64570787
29EIF2AK31.59851241
30AURKB1.59068138
31TGFBR11.59016001
32CCNB11.57529786
33NME21.55272413
34CDK41.52953691
35FLT31.50957300
36SCYL21.47780407
37NEK11.46829543
38RPS6KA41.41633457
39MAP3K81.39079505
40MKNK21.37956768
41PLK41.36996021
42TESK21.32971530
43BRSK11.32963528
44MAP4K11.32760910
45CDK121.28505017
46MST41.25714216
47CHEK21.23785657
48PLK31.18428938
49PAK41.14186938
50CHEK11.13871622
51STK41.13271837
52PKN21.12726110
53BTK1.09223241
54TRIM281.06682933
55CLK11.01459614
56LRRK21.00222105
57MAP2K31.00049830
58AURKA0.97461117
59PIM10.92702905
60ATM0.90018203
61NME10.89665620
62PIM20.87524019
63LATS10.86547298
64KIT0.86406483
65CDK20.84916492
66CDK80.83519168
67TEC0.82120251
68CDK60.73999727
69BRD40.71989978
70GRK60.67996890
71CSNK2A20.66024381
72CSF1R0.65493431
73YES10.63950363
74CDK30.61973941
75STK30.61890481
76CSNK2A10.60228545
77PNCK0.58961225
78CDK90.58938407
79CDK10.58731900
80MAPKAPK30.58109242
81TAOK20.56481130
82ZAP700.55456030
83DAPK10.54982075
84ALK0.54703586
85JAK30.52079705
86EIF2AK20.50463171
87MAP3K110.48966870
88ZAK0.48286216
89PAK10.48208874
90MATK0.48129250
91CSNK1G30.48120470
92KDR0.47345416
93MAPKAPK50.46717299
94CSNK1G10.46644102
95MAPK110.43884816
96CSNK1E0.41705243
97BMPR1B0.41085889
98MAP2K60.38263672
99BRAF0.37328003
100BLK0.34864460
101SYK0.34036954
102RPS6KA50.33927633
103RAF10.33454271
104CSNK1A1L0.31263061
105PRKDC0.30588967
106WNK30.30110239
107ERBB40.30046697
108LYN0.29979206
109FGFR10.29845692
110CDK11A0.29639547
111ILK0.29459108
112RPS6KL10.29409401
113RPS6KC10.29409401
114AKT20.29147972
115RPS6KA60.28834873
116DYRK20.27947433
117CSNK1G20.27765005
118CDK180.27497999
119MELK0.27105495
120CDK150.27010378
121CDK140.26226752
122GSK3B0.25483453
123RPS6KB10.24989670
124MAPK140.24167072
125BCKDK0.23894987
126IRAK40.23684818
127PRKCI0.21793423
128TRIB30.21624142
129CDK190.21356965
130LCK0.21275694
131STK38L0.20308351
132ERBB30.18786370
133BCR0.17845545

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.02760801
2Mismatch repair_Homo sapiens_hsa034304.91335617
3Ribosome_Homo sapiens_hsa030103.48017102
4Base excision repair_Homo sapiens_hsa034103.41668424
5Homologous recombination_Homo sapiens_hsa034403.36656223
6Spliceosome_Homo sapiens_hsa030403.30725646
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13510508
8Nucleotide excision repair_Homo sapiens_hsa034203.04125581
9Cell cycle_Homo sapiens_hsa041102.86392914
10One carbon pool by folate_Homo sapiens_hsa006702.75683085
11RNA transport_Homo sapiens_hsa030132.74203633
12RNA polymerase_Homo sapiens_hsa030202.63553014
13Non-homologous end-joining_Homo sapiens_hsa034502.51510919
14Pyrimidine metabolism_Homo sapiens_hsa002402.43677131
15Proteasome_Homo sapiens_hsa030502.35867585
16Fanconi anemia pathway_Homo sapiens_hsa034602.34379138
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24466060
18RNA degradation_Homo sapiens_hsa030181.77103192
19mRNA surveillance pathway_Homo sapiens_hsa030151.61973058
20Basal transcription factors_Homo sapiens_hsa030221.54230809
21p53 signaling pathway_Homo sapiens_hsa041151.45662450
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26702649
23Purine metabolism_Homo sapiens_hsa002301.26408769
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18872105
25Systemic lupus erythematosus_Homo sapiens_hsa053221.17591060
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09477662
27Herpes simplex infection_Homo sapiens_hsa051681.06468730
28Pyruvate metabolism_Homo sapiens_hsa006201.06210747
29Epstein-Barr virus infection_Homo sapiens_hsa051691.04738565
30Primary immunodeficiency_Homo sapiens_hsa053400.99570992
31Viral carcinogenesis_Homo sapiens_hsa052030.96635981
32Propanoate metabolism_Homo sapiens_hsa006400.96478015
33Antigen processing and presentation_Homo sapiens_hsa046120.95183389
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.90083540
35Pentose phosphate pathway_Homo sapiens_hsa000300.85306899
36Thyroid cancer_Homo sapiens_hsa052160.81831184
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80227506
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78163657
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77856418
40Fatty acid elongation_Homo sapiens_hsa000620.77461728
41Oocyte meiosis_Homo sapiens_hsa041140.76923792
42Folate biosynthesis_Homo sapiens_hsa007900.75972180
43HTLV-I infection_Homo sapiens_hsa051660.75669611
44Parkinsons disease_Homo sapiens_hsa050120.75461446
45Biosynthesis of amino acids_Homo sapiens_hsa012300.74520006
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73233045
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70436590
48Selenocompound metabolism_Homo sapiens_hsa004500.69124932
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.68300192
50Steroid biosynthesis_Homo sapiens_hsa001000.67266642
51Legionellosis_Homo sapiens_hsa051340.63924287
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.62402664
53N-Glycan biosynthesis_Homo sapiens_hsa005100.61330765
54Small cell lung cancer_Homo sapiens_hsa052220.60994625
55Sulfur relay system_Homo sapiens_hsa041220.60653510
56Vitamin B6 metabolism_Homo sapiens_hsa007500.59264914
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56680904
58MicroRNAs in cancer_Homo sapiens_hsa052060.56559501
59Measles_Homo sapiens_hsa051620.55091670
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54821541
61Colorectal cancer_Homo sapiens_hsa052100.54156491
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52905346
63Oxidative phosphorylation_Homo sapiens_hsa001900.52808517
64Fatty acid metabolism_Homo sapiens_hsa012120.50578472
65Hepatitis B_Homo sapiens_hsa051610.47914837
66Chronic myeloid leukemia_Homo sapiens_hsa052200.46316414
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44006152
68Apoptosis_Homo sapiens_hsa042100.43141354
69Protein export_Homo sapiens_hsa030600.42412729
70Alcoholism_Homo sapiens_hsa050340.42235625
71Glutathione metabolism_Homo sapiens_hsa004800.41776054
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41327678
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40691028
74Acute myeloid leukemia_Homo sapiens_hsa052210.40181495
75Shigellosis_Homo sapiens_hsa051310.38410057
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.38261482
77Carbon metabolism_Homo sapiens_hsa012000.38236403
78Notch signaling pathway_Homo sapiens_hsa043300.35676543
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35501513
80Hematopoietic cell lineage_Homo sapiens_hsa046400.35269930
81Vitamin digestion and absorption_Homo sapiens_hsa049770.34678331
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34238455
83Non-small cell lung cancer_Homo sapiens_hsa052230.33729416
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33348662
85Basal cell carcinoma_Homo sapiens_hsa052170.33164955
86Influenza A_Homo sapiens_hsa051640.32678929
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29872899
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28603508
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.27390191
90Leishmaniasis_Homo sapiens_hsa051400.26372642
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24931234
92Pathways in cancer_Homo sapiens_hsa052000.24024276
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23779963
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23477214
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22682189
96Lysine degradation_Homo sapiens_hsa003100.22191609
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.22190245
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21864403
99Galactose metabolism_Homo sapiens_hsa000520.21693500
100Bladder cancer_Homo sapiens_hsa052190.21541113
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21361808
102B cell receptor signaling pathway_Homo sapiens_hsa046620.20712214
103Fatty acid degradation_Homo sapiens_hsa000710.20626841
104Peroxisome_Homo sapiens_hsa041460.19027072
105Huntingtons disease_Homo sapiens_hsa050160.18840774
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18033007
107Hippo signaling pathway_Homo sapiens_hsa043900.18020157
108Alzheimers disease_Homo sapiens_hsa050100.17994950
109Butanoate metabolism_Homo sapiens_hsa006500.17793325
110Viral myocarditis_Homo sapiens_hsa054160.17151865
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17134046
112Wnt signaling pathway_Homo sapiens_hsa043100.16411646
113HIF-1 signaling pathway_Homo sapiens_hsa040660.16311831
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15571217
115TGF-beta signaling pathway_Homo sapiens_hsa043500.15189126
116Renin-angiotensin system_Homo sapiens_hsa046140.14208501
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13678221
118Pancreatic cancer_Homo sapiens_hsa052120.13526157
119Prostate cancer_Homo sapiens_hsa052150.13299305
120Fructose and mannose metabolism_Homo sapiens_hsa000510.13177950
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.13033329
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12731368
123T cell receptor signaling pathway_Homo sapiens_hsa046600.12255494
124Metabolic pathways_Homo sapiens_hsa011000.11926327
125Arginine and proline metabolism_Homo sapiens_hsa003300.06138471
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03785202
127Melanoma_Homo sapiens_hsa052180.03279895

Most similar genes based on co-expression Upload to Enrichr

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