CDCA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.40018404
2* mitotic metaphase plate congression (GO:0007080)5.02123103
3protein localization to chromosome, centromeric region (GO:0071459)4.93899082
4DNA topological change (GO:0006265)4.87153521
5DNA ligation (GO:0006266)4.81945934
6kinetochore organization (GO:0051383)4.81479328
7mitotic sister chromatid segregation (GO:0000070)4.80005040
8CENP-A containing nucleosome assembly (GO:0034080)4.78574729
9chromatin remodeling at centromere (GO:0031055)4.66467586
10attachment of spindle microtubules to kinetochore (GO:0008608)4.62953994
11DNA strand elongation involved in DNA replication (GO:0006271)4.62189399
12kinetochore assembly (GO:0051382)4.48132938
13mitotic chromosome condensation (GO:0007076)4.47215288
14DNA replication checkpoint (GO:0000076)4.46714876
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.41877972
16* metaphase plate congression (GO:0051310)4.40764941
17regulation of spindle organization (GO:0090224)4.39822289
18DNA strand elongation (GO:0022616)4.38644664
19DNA replication initiation (GO:0006270)4.37434227
20telomere maintenance via semi-conservative replication (GO:0032201)4.36463651
21sister chromatid segregation (GO:0000819)4.31462924
22DNA replication-independent nucleosome organization (GO:0034724)4.26755982
23DNA replication-independent nucleosome assembly (GO:0006336)4.26755982
24* establishment of chromosome localization (GO:0051303)4.18725203
25establishment of integrated proviral latency (GO:0075713)4.16668785
26DNA unwinding involved in DNA replication (GO:0006268)4.13511477
27mitotic nuclear envelope disassembly (GO:0007077)4.09307906
28histone exchange (GO:0043486)4.05017723
29telomere maintenance via recombination (GO:0000722)4.01672038
30mitotic recombination (GO:0006312)3.93125465
31spindle checkpoint (GO:0031577)3.93032929
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87349839
33DNA packaging (GO:0006323)3.84782983
34meiotic chromosome segregation (GO:0045132)3.83973034
35regulation of chromosome segregation (GO:0051983)3.77876795
36membrane disassembly (GO:0030397)3.76822563
37nuclear envelope disassembly (GO:0051081)3.76822563
38maturation of SSU-rRNA (GO:0030490)3.74986893
39negative regulation of chromosome segregation (GO:0051985)3.72327975
40positive regulation of chromosome segregation (GO:0051984)3.71192212
41regulation of mitotic spindle organization (GO:0060236)3.71083283
42mitotic sister chromatid cohesion (GO:0007064)3.71009034
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69483509
44negative regulation of sister chromatid segregation (GO:0033046)3.69483509
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.69483509
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69483509
47spindle assembly checkpoint (GO:0071173)3.69246438
48DNA replication-dependent nucleosome assembly (GO:0006335)3.68016575
49DNA replication-dependent nucleosome organization (GO:0034723)3.68016575
50telomere maintenance via telomere lengthening (GO:0010833)3.64889291
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.64849101
52protein localization to chromosome (GO:0034502)3.64614131
53mitotic spindle assembly checkpoint (GO:0007094)3.62667571
54ribosomal small subunit assembly (GO:0000028)3.61208938
55nucleobase biosynthetic process (GO:0046112)3.60099638
56formation of translation preinitiation complex (GO:0001731)3.58878838
57mitotic spindle checkpoint (GO:0071174)3.57688834
58chromosome segregation (GO:0007059)3.57360996
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55649652
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.52382925
61DNA deamination (GO:0045006)3.44154816
62purine nucleobase biosynthetic process (GO:0009113)3.42610417
63regulation of mitotic sister chromatid separation (GO:0010965)3.40531974
64regulation of mitotic sister chromatid segregation (GO:0033047)3.40531974
65regulation of sister chromatid segregation (GO:0033045)3.40531974
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40470635
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.39744381
68ribosomal large subunit biogenesis (GO:0042273)3.34279221
69establishment of viral latency (GO:0019043)3.33869083
70ventricular cardiac muscle cell development (GO:0055015)3.32942353
71chromatin assembly or disassembly (GO:0006333)3.31231764
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.30941054
73nuclear pore organization (GO:0006999)3.30539204
74spliceosomal snRNP assembly (GO:0000387)3.28478453
75ribosome assembly (GO:0042255)3.26256773
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25862415
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25862415
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.25862415
79viral transcription (GO:0019083)3.21843387
80DNA conformation change (GO:0071103)3.21643121
81ATP-dependent chromatin remodeling (GO:0043044)3.21277093
82protein K6-linked ubiquitination (GO:0085020)3.20885653
83protein complex localization (GO:0031503)3.20614216
84translational termination (GO:0006415)3.19758688
85regulation of sister chromatid cohesion (GO:0007063)3.18478562
86microtubule depolymerization (GO:0007019)3.17713166
87negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.17423304
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15904946
89ribonucleoprotein complex biogenesis (GO:0022613)3.15290809
90ribosome biogenesis (GO:0042254)3.14478169
91regulation of centrosome cycle (GO:0046605)3.14452970
92ribosomal small subunit biogenesis (GO:0042274)3.12411620
93pore complex assembly (GO:0046931)3.12149313
94negative regulation of cell division (GO:0051782)3.06940170
95histone-serine phosphorylation (GO:0035404)3.06233635
96* mitotic cell cycle (GO:0000278)3.06078100
97nuclear pore complex assembly (GO:0051292)3.05605117
98translational initiation (GO:0006413)3.05583147
99mitotic cytokinesis (GO:0000281)3.04976664
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04608296
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04603620
102mitotic spindle organization (GO:0007052)3.04061373
103regulation of exit from mitosis (GO:0007096)3.02814880
104transcription-coupled nucleotide-excision repair (GO:0006283)3.02085860
105negative regulation of nuclear division (GO:0051784)3.01757244
106rRNA processing (GO:0006364)3.01607533
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01533215
108negative regulation of ligase activity (GO:0051352)3.01533215
109regulation of centriole replication (GO:0046599)3.01167628
110proteasome assembly (GO:0043248)3.00005366
111negative regulation of mitosis (GO:0045839)2.99333317
112chromosome condensation (GO:0030261)2.99325306
113mitotic nuclear division (GO:0007067)2.99240862
114spindle organization (GO:0007051)2.97936668
115establishment of mitotic spindle localization (GO:0040001)2.97269801
116spliceosomal complex assembly (GO:0000245)2.97200133
117negative regulation of proteasomal protein catabolic process (GO:1901799)2.96260140
118deoxyribonucleotide biosynthetic process (GO:0009263)2.96234635
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95789510
120DNA duplex unwinding (GO:0032508)2.95528698
121nuclear envelope organization (GO:0006998)2.93867387
122folic acid-containing compound biosynthetic process (GO:0009396)2.93037482
123translational elongation (GO:0006414)2.92707874
124rRNA metabolic process (GO:0016072)2.92345641
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.92332229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.73240704
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.05065970
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19190953
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.10118512
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.08862435
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49507588
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29424968
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.95152012
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89962947
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76089014
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74400172
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.73336096
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69945409
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68122169
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66717044
16* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56638319
17* AR_21909140_ChIP-Seq_LNCAP_Human2.49209980
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40156463
19* XRN2_22483619_ChIP-Seq_HELA_Human2.38004812
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32925153
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24395183
22VDR_23849224_ChIP-Seq_CD4+_Human2.15422195
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.11404450
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10367035
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07411168
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97037020
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94357832
28FOXP3_21729870_ChIP-Seq_TREG_Human1.93262060
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89745048
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88258427
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84900772
32TTF2_22483619_ChIP-Seq_HELA_Human1.84108140
33GABP_19822575_ChIP-Seq_HepG2_Human1.82101860
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77635973
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76720160
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73403391
37* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72619475
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72276400
39* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70116425
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69339891
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67964057
42CIITA_25753668_ChIP-Seq_RAJI_Human1.65306645
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59844436
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55106332
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.54669804
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.52144143
47ELK1_19687146_ChIP-ChIP_HELA_Human1.46554170
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45866404
49* KDM5A_27292631_Chip-Seq_BREAST_Human1.45383004
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44850549
51MYC_22102868_ChIP-Seq_BL_Human1.41562145
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.39137388
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39109645
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38764185
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38431613
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38138091
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34200923
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33836209
59* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25570316
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25214243
61* SRF_21415370_ChIP-Seq_HL-1_Mouse1.24044143
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20750396
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20619756
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19388069
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16042837
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14237966
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12354679
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09251585
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09054750
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08584464
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08004922
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07605495
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07243100
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06561602
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06528164
76MYC_18940864_ChIP-ChIP_HL60_Human1.04441090
77TFEB_21752829_ChIP-Seq_HELA_Human1.01676016
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00027053
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97785505
80VDR_21846776_ChIP-Seq_THP-1_Human0.95948315
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95597545
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94479952
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.93916319
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92448658
85* NANOG_21062744_ChIP-ChIP_HESCs_Human0.90798505
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90114332
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88046148
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87465360
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87073194
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85604053
91SALL1_21062744_ChIP-ChIP_HESCs_Human0.85178705
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84869340
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82698071
94SPI1_23547873_ChIP-Seq_NB4_Human0.80550534
95CHD1_26751641_Chip-Seq_LNCaP_Human0.80329929
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79405359
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.79017405
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78992983
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78644430
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78263856
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.78178295
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77749467
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.75538812
104ZNF263_19887448_ChIP-Seq_K562_Human0.75530249
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74577539
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74079270
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72956966
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71511231
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71340378
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.70528523
111* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70176832
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68604356
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67304440
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67251462
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66877728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching5.70189143
2* MP0003111_abnormal_nucleus_morphology5.20571897
3MP0010094_abnormal_chromosome_stability4.95074187
4MP0004957_abnormal_blastocyst_morpholog4.75286552
5* MP0003077_abnormal_cell_cycle4.47958053
6MP0008057_abnormal_DNA_replication3.82581207
7MP0008058_abnormal_DNA_repair3.30978651
8MP0008007_abnormal_cellular_replicative2.97686809
9MP0008932_abnormal_embryonic_tissue2.91085183
10MP0001730_embryonic_growth_arrest2.43851445
11MP0009697_abnormal_copulation2.40181908
12MP0000350_abnormal_cell_proliferation2.33341338
13MP0003123_paternal_imprinting2.31789384
14MP0008877_abnormal_DNA_methylation2.21800276
15MP0003718_maternal_effect2.17424940
16MP0002396_abnormal_hematopoietic_system2.13061606
17MP0003786_premature_aging1.89643207
18MP0005380_embryogenesis_phenotype1.85981068
19MP0001672_abnormal_embryogenesis/_devel1.85981068
20MP0001697_abnormal_embryo_size1.83016850
21MP0000490_abnormal_crypts_of1.79991624
22MP0010307_abnormal_tumor_latency1.79969342
23MP0002085_abnormal_embryonic_tissue1.65266870
24* MP0002080_prenatal_lethality1.61761015
25MP0003984_embryonic_growth_retardation1.60621822
26MP0010030_abnormal_orbit_morphology1.58125602
27MP0002088_abnormal_embryonic_growth/wei1.56743450
28MP0010352_gastrointestinal_tract_polyps1.54485550
29* MP0000313_abnormal_cell_death1.47894855
30MP0002019_abnormal_tumor_incidence1.46995505
31MP0002084_abnormal_developmental_patter1.42839674
32MP0002210_abnormal_sex_determination1.40195702
33MP0002086_abnormal_extraembryonic_tissu1.38337179
34MP0003315_abnormal_perineum_morphology1.33702883
35MP0004808_abnormal_hematopoietic_stem1.33502574
36MP0003567_abnormal_fetal_cardiomyocyte1.32290328
37MP0001346_abnormal_lacrimal_gland1.29800543
38MP0006292_abnormal_olfactory_placode1.28821325
39MP0002877_abnormal_melanocyte_morpholog1.27677124
40MP0006035_abnormal_mitochondrial_morpho1.25127793
41MP0002102_abnormal_ear_morphology1.24230178
42MP0003121_genomic_imprinting1.24141606
43MP0004197_abnormal_fetal_growth/weight/1.23302147
44MP0001145_abnormal_male_reproductive1.21041281
45MP0001929_abnormal_gametogenesis1.19415986
46MP0001545_abnormal_hematopoietic_system1.14089480
47MP0005397_hematopoietic_system_phenotyp1.14089480
48MP0005076_abnormal_cell_differentiation1.13565219
49MP0003890_abnormal_embryonic-extraembry1.11826057
50MP0004233_abnormal_muscle_weight1.11108546
51MP0009333_abnormal_splenocyte_physiolog1.11100193
52MP0000566_synostosis1.10719898
53MP0001293_anophthalmia1.10645542
54MP0002697_abnormal_eye_size1.09280028
55MP0000653_abnormal_sex_gland1.08483124
56MP0002653_abnormal_ependyma_morphology1.02952813
57MP0000703_abnormal_thymus_morphology1.01122671
58MP0001119_abnormal_female_reproductive0.99709789
59MP0003937_abnormal_limbs/digits/tail_de0.98821033
60MP0003119_abnormal_digestive_system0.95924575
61MP0009053_abnormal_anal_canal0.94682270
62MP0005501_abnormal_skin_physiology0.92348195
63MP0006036_abnormal_mitochondrial_physio0.91896502
64MP0002398_abnormal_bone_marrow0.90559077
65MP0003763_abnormal_thymus_physiology0.90096175
66MP0003705_abnormal_hypodermis_morpholog0.89703365
67MP0002722_abnormal_immune_system0.89095782
68MP0009672_abnormal_birth_weight0.88960289
69MP0002132_abnormal_respiratory_system0.87522810
70MP0002234_abnormal_pharynx_morphology0.83708314
71MP0001529_abnormal_vocalization0.83203885
72MP0000537_abnormal_urethra_morphology0.83102848
73MP0002111_abnormal_tail_morphology0.82115489
74MP0000689_abnormal_spleen_morphology0.80423800
75MP0002160_abnormal_reproductive_system0.79963486
76MP0000858_altered_metastatic_potential0.79774833
77MP0003941_abnormal_skin_development0.78402022
78MP0005389_reproductive_system_phenotype0.77604131
79MP0003861_abnormal_nervous_system0.77437707
80MP0005384_cellular_phenotype0.75872629
81MP0005621_abnormal_cell_physiology0.75171736
82MP0000358_abnormal_cell_content/0.72652507
83MP0004133_heterotaxia0.72650843
84MP0005623_abnormal_meninges_morphology0.72013651
85MP0001286_abnormal_eye_development0.70966951
86MP0009278_abnormal_bone_marrow0.70631330
87MP0002429_abnormal_blood_cell0.70548817
88MP0003385_abnormal_body_wall0.69257620
89MP0002233_abnormal_nose_morphology0.68774747
90MP0000428_abnormal_craniofacial_morphol0.67646383
91MP0001919_abnormal_reproductive_system0.67443692
92MP0003699_abnormal_female_reproductive0.66499840
93MP0005394_taste/olfaction_phenotype0.66331686
94MP0005499_abnormal_olfactory_system0.66331686
95MP0003938_abnormal_ear_development0.66297980
96MP0003221_abnormal_cardiomyocyte_apopto0.65988505
97MP0000372_irregular_coat_pigmentation0.65740409
98MP0003950_abnormal_plasma_membrane0.64746204
99MP0001915_intracranial_hemorrhage0.64308451
100MP0003806_abnormal_nucleotide_metabolis0.64135487
101MP0003186_abnormal_redox_activity0.63874805
102MP0001661_extended_life_span0.63582006
103MP0003755_abnormal_palate_morphology0.62603211
104MP0006054_spinal_hemorrhage0.62037182
105MP0003942_abnormal_urinary_system0.61647410
106MP0005408_hypopigmentation0.61495017
107MP0002938_white_spotting0.61268544
108MP0004185_abnormal_adipocyte_glucose0.61108387
109MP0009703_decreased_birth_body0.60401989
110MP0003935_abnormal_craniofacial_develop0.60270959
111MP0001727_abnormal_embryo_implantation0.59765743
112MP0002092_abnormal_eye_morphology0.59734803
113MP0000477_abnormal_intestine_morphology0.59531379
114MP0002161_abnormal_fertility/fecundity0.58742422
115MP0000678_abnormal_parathyroid_gland0.58207424
116MP0003115_abnormal_respiratory_system0.58068265
117MP0001881_abnormal_mammary_gland0.57866914
118MP0005023_abnormal_wound_healing0.55886983
119MP0000432_abnormal_head_morphology0.54925743
120MP0003698_abnormal_male_reproductive0.54592171
121MP0005395_other_phenotype0.54524102
122MP0008995_early_reproductive_senescence0.53813959
123MP0000716_abnormal_immune_system0.53503295
124MP0003943_abnormal_hepatobiliary_system0.52795645
125MP0002796_impaired_skin_barrier0.52719739
126MP0000049_abnormal_middle_ear0.52137140
127MP0009379_abnormal_foot_pigmentation0.52056529
128MP0002932_abnormal_joint_morphology0.51336231
129MP0005451_abnormal_body_composition0.49782541
130MP0008789_abnormal_olfactory_epithelium0.49669208

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.07684774
2Chromsome breakage (HP:0040012)4.57725959
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47801736
4Reticulocytopenia (HP:0001896)4.41099061
5Breast hypoplasia (HP:0003187)4.38858874
6Patellar aplasia (HP:0006443)4.01082405
7Aplasia/Hypoplasia of the patella (HP:0006498)3.78538758
8Meckel diverticulum (HP:0002245)3.69654928
9Abnormality of cells of the erythroid lineage (HP:0012130)3.68754228
10Cortical dysplasia (HP:0002539)3.67600068
11Abnormality of the preputium (HP:0100587)3.61675328
12Oral leukoplakia (HP:0002745)3.57868476
13Carpal bone hypoplasia (HP:0001498)3.56139272
14Abnormal number of erythroid precursors (HP:0012131)3.54914156
15Abnormality of the ileum (HP:0001549)3.50821024
16Abnormality of chromosome stability (HP:0003220)3.47173954
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.29418109
18Duodenal stenosis (HP:0100867)3.28262913
19Small intestinal stenosis (HP:0012848)3.28262913
20Colon cancer (HP:0003003)3.21392755
21Absent radius (HP:0003974)3.15368763
22Impulsivity (HP:0100710)3.15053060
23Absent thumb (HP:0009777)2.98184641
24Selective tooth agenesis (HP:0001592)2.98060781
25Absent forearm bone (HP:0003953)2.94699480
26Aplasia involving forearm bones (HP:0009822)2.94699480
27Myelodysplasia (HP:0002863)2.91919939
28Medulloblastoma (HP:0002885)2.89652038
29Rough bone trabeculation (HP:0100670)2.89253726
30Abnormal lung lobation (HP:0002101)2.87842067
31Degeneration of anterior horn cells (HP:0002398)2.78860620
32Abnormality of the anterior horn cell (HP:0006802)2.78860620
33Aplastic anemia (HP:0001915)2.72447300
34Abnormality of the duodenum (HP:0002246)2.65837865
35Bone marrow hypocellularity (HP:0005528)2.63516622
36Sloping forehead (HP:0000340)2.61522680
37Ectopic kidney (HP:0000086)2.59119087
38Macrocytic anemia (HP:0001972)2.58494461
39Horseshoe kidney (HP:0000085)2.58256327
40Increased nuchal translucency (HP:0010880)2.58055257
41Pallor (HP:0000980)2.56652788
42Triphalangeal thumb (HP:0001199)2.56039478
43Duplicated collecting system (HP:0000081)2.54109780
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53283174
45Cerebral hypomyelination (HP:0006808)2.51602635
46Abnormal umbilical cord blood vessels (HP:0011403)2.50936537
47Single umbilical artery (HP:0001195)2.50936537
48Abnormality of the fetal cardiovascular system (HP:0010948)2.50936537
49Abnormal number of incisors (HP:0011064)2.46523472
50Cholecystitis (HP:0001082)2.45210839
51Abnormal gallbladder physiology (HP:0012438)2.45210839
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44898711
53Broad distal phalanx of finger (HP:0009836)2.44720814
54Microvesicular hepatic steatosis (HP:0001414)2.43291801
55Tracheoesophageal fistula (HP:0002575)2.43201279
56Neoplasm of the pancreas (HP:0002894)2.42663325
5711 pairs of ribs (HP:0000878)2.42283049
58Rhabdomyosarcoma (HP:0002859)2.38258434
59Microretrognathia (HP:0000308)2.36938683
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34369279
61Supernumerary spleens (HP:0009799)2.32380535
62Premature graying of hair (HP:0002216)2.31656912
63Abnormality of glycolysis (HP:0004366)2.31300839
64Hypoplastic pelvis (HP:0008839)2.31092634
65Nephroblastoma (Wilms tumor) (HP:0002667)2.30799328
66Premature ovarian failure (HP:0008209)2.29929137
67Atresia of the external auditory canal (HP:0000413)2.29856447
68Ependymoma (HP:0002888)2.29016962
69Secondary amenorrhea (HP:0000869)2.28950075
70Abnormality of the labia minora (HP:0012880)2.28231920
71Abnormality of the carotid arteries (HP:0005344)2.26255623
72Cleft eyelid (HP:0000625)2.26053992
73Agnosia (HP:0010524)2.25191885
74Short thumb (HP:0009778)2.22881538
75Abnormality of the umbilical cord (HP:0010881)2.22111720
76Trismus (HP:0000211)2.20024902
77Cellular immunodeficiency (HP:0005374)2.16633061
78Abnormality of the renal collecting system (HP:0004742)2.15932274
79Embryonal renal neoplasm (HP:0011794)2.12698439
80Abnormal trabecular bone morphology (HP:0100671)2.10422414
81High anterior hairline (HP:0009890)2.09816482
82Squamous cell carcinoma (HP:0002860)2.09638384
83Clubbing of toes (HP:0100760)2.07925272
84Cafe-au-lait spot (HP:0000957)2.07865529
85Duplication of thumb phalanx (HP:0009942)2.06959277
86Aplasia/Hypoplasia of the sternum (HP:0006714)2.06771812
87Small epiphyses (HP:0010585)2.05683869
88Embryonal neoplasm (HP:0002898)2.04199599
89Increased serum pyruvate (HP:0003542)2.02672396
90Facial hemangioma (HP:0000329)2.01820291
91Proximal placement of thumb (HP:0009623)2.00977020
92Overlapping toe (HP:0001845)1.94394875
93Basal cell carcinoma (HP:0002671)1.92951611
94Deep philtrum (HP:0002002)1.92580976
95Progressive muscle weakness (HP:0003323)1.91106041
96Neoplasm of the colon (HP:0100273)1.90595531
97Abnormality of cochlea (HP:0000375)1.90275791
98Deviation of the thumb (HP:0009603)1.90036566
99Ureteral duplication (HP:0000073)1.88898928
100Abnormality of chromosome segregation (HP:0002916)1.88227139
101Abnormality of DNA repair (HP:0003254)1.88223354
102Arteriovenous malformation (HP:0100026)1.87706220
103Prominent nose (HP:0000448)1.87533426
104Multiple enchondromatosis (HP:0005701)1.87490120
105Abnormality of the heme biosynthetic pathway (HP:0010472)1.87414102
106Abnormality of abdominal situs (HP:0011620)1.87053225
107Abdominal situs inversus (HP:0003363)1.87053225
108Facial cleft (HP:0002006)1.87033393
109Abnormality of reticulocytes (HP:0004312)1.83207222
110Progressive external ophthalmoplegia (HP:0000590)1.82622855
111High pitched voice (HP:0001620)1.81436596
112Poikiloderma (HP:0001029)1.77757117
113Hypoplasia of the radius (HP:0002984)1.77739836
114Absent epiphyses (HP:0010577)1.73359243
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73359243
116Volvulus (HP:0002580)1.73314814
117Abnormality of pyrimidine metabolism (HP:0004353)1.73073050
118Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71580110
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.71311192
120Short middle phalanx of the 5th finger (HP:0004220)1.71281892
121Slender long bone (HP:0003100)1.70878965
122Pancytopenia (HP:0001876)1.69517682
123Abnormal spermatogenesis (HP:0008669)1.69274826
124Choanal atresia (HP:0000453)1.68691773
125Missing ribs (HP:0000921)1.64148924
126Entropion (HP:0000621)1.62708067
127Irregular epiphyses (HP:0010582)1.62659048
128Type I transferrin isoform profile (HP:0003642)1.61818246
129Flared metaphyses (HP:0003015)1.61469951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.45434009
2WEE14.37880807
3CDC74.20751448
4NEK23.53549843
5VRK22.99029567
6EIF2AK12.76964944
7PLK42.61564992
8BRSK22.51482410
9SRPK12.45182269
10PLK12.39714069
11NEK12.35120269
12* TTK2.14962170
13* AURKB1.92962454
14BRSK11.92563314
15TESK21.81552094
16SMG11.78806694
17CCNB11.77765148
18NME21.75673250
19STK161.75431883
20ACVR1B1.74904792
21CHEK21.72394081
22VRK11.67151454
23CDK71.65879658
24PLK31.64650010
25TLK11.63903386
26AURKA1.62356174
27MKNK11.61698560
28DYRK31.60936585
29ATR1.57714504
30STK101.57005873
31RPS6KA41.48458257
32MAP3K81.45634230
33TSSK61.41389173
34CDK41.39376821
35MKNK21.37367350
36STK41.36759872
37EIF2AK31.32719593
38CDK121.32505797
39TAF11.29607631
40RPS6KB21.27832154
41CHEK11.24508199
42EPHA21.18429342
43MELK1.14619474
44PASK1.08171186
45BRAF1.06762285
46PAK41.04763371
47PBK1.03177968
48MAP3K101.02466180
49CDK80.96820652
50EEF2K0.91997745
51STK38L0.89952011
52ATM0.86074088
53ZAK0.85479854
54MST40.84795961
55CDK20.82759506
56EIF2AK20.82310849
57STK30.76937589
58PAK10.76731578
59TRIM280.74222614
60LATS20.74113366
61PIM10.70952845
62CDK10.69500313
63CLK10.69079035
64CDK60.66681988
65KDR0.64404484
66TGFBR10.62991814
67CSNK2A10.61608503
68MAP4K10.55241518
69PRKCI0.54623350
70CSNK2A20.54470869
71SCYL20.52873439
72TESK10.52593616
73BRD40.52522425
74LRRK20.51598094
75NUAK10.49613024
76MAP3K110.46874742
77UHMK10.46404202
78MST1R0.46236855
79DYRK20.44364778
80CDK140.43643151
81RPS6KA50.43448636
82ICK0.43341045
83IRAK30.43296171
84LATS10.40662370
85MARK30.39233391
86AKT20.37160748
87ERBB40.36749026
88ALK0.36745366
89MET0.31529503
90RAF10.31425092
91PIM20.31363433
92BLK0.31099950
93PDK20.27506729
94ABL20.27480847
95NME10.27093386
96PRKDC0.26094084
97MAP2K30.25979110
98ARAF0.25890974
99MAPKAPK30.25249474
100MAP3K60.24234418
101PNCK0.23212903
102CDK30.22870617
103CSNK1E0.22647308
104ILK0.22298872
105CDK11A0.21955199
106MAPK110.21101296
107MAPKAPK20.20705023
108MTOR0.19949118
109CDK90.19375100
110TRIB30.17740053
111CDK150.17731796
112MAPK140.17278503
113AKT10.16263560
114CDK180.15765543
115BTK0.15493514
116PAK20.15364874
117MAPKAPK50.14820363
118BMX0.14436996
119CAMK1G0.14347394
120FLT30.13825131
121TAOK20.13623460
122NEK90.13210403

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02532383
2Mismatch repair_Homo sapiens_hsa034304.25903777
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45058481
4Homologous recombination_Homo sapiens_hsa034403.40691905
5Spliceosome_Homo sapiens_hsa030403.40625993
6Ribosome_Homo sapiens_hsa030103.33331067
7Base excision repair_Homo sapiens_hsa034103.29921441
8Cell cycle_Homo sapiens_hsa041103.28397057
9RNA polymerase_Homo sapiens_hsa030203.23512549
10RNA transport_Homo sapiens_hsa030133.19587052
11Proteasome_Homo sapiens_hsa030503.11225404
12Nucleotide excision repair_Homo sapiens_hsa034202.89296956
13Fanconi anemia pathway_Homo sapiens_hsa034602.62253059
14Pyrimidine metabolism_Homo sapiens_hsa002402.49870599
15One carbon pool by folate_Homo sapiens_hsa006702.30539167
16Basal transcription factors_Homo sapiens_hsa030222.17378499
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15568098
18RNA degradation_Homo sapiens_hsa030182.03531929
19Non-homologous end-joining_Homo sapiens_hsa034502.01617157
20mRNA surveillance pathway_Homo sapiens_hsa030151.84195716
21p53 signaling pathway_Homo sapiens_hsa041151.80757225
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75549592
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55290267
24Oocyte meiosis_Homo sapiens_hsa041141.38584028
25Purine metabolism_Homo sapiens_hsa002301.30643291
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29287432
27Epstein-Barr virus infection_Homo sapiens_hsa051691.19898064
28Vitamin B6 metabolism_Homo sapiens_hsa007501.17450434
29Systemic lupus erythematosus_Homo sapiens_hsa053221.10923069
30Pyruvate metabolism_Homo sapiens_hsa006201.10486206
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10100591
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09927902
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02608499
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01432198
35Herpes simplex infection_Homo sapiens_hsa051680.94446031
36Fatty acid elongation_Homo sapiens_hsa000620.94034074
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91161180
38Viral carcinogenesis_Homo sapiens_hsa052030.88656447
39Pentose phosphate pathway_Homo sapiens_hsa000300.87722273
40HTLV-I infection_Homo sapiens_hsa051660.81297156
41Oxidative phosphorylation_Homo sapiens_hsa001900.76939307
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73810678
43Steroid biosynthesis_Homo sapiens_hsa001000.73773441
44Folate biosynthesis_Homo sapiens_hsa007900.72616501
45MicroRNAs in cancer_Homo sapiens_hsa052060.72008005
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.69325818
47Antigen processing and presentation_Homo sapiens_hsa046120.67242955
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66779198
49Biosynthesis of amino acids_Homo sapiens_hsa012300.65087273
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64899329
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.61052196
52Small cell lung cancer_Homo sapiens_hsa052220.60627288
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.59786542
54Lysine degradation_Homo sapiens_hsa003100.58472257
55Huntingtons disease_Homo sapiens_hsa050160.57146196
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56104113
57Thyroid cancer_Homo sapiens_hsa052160.54901018
58Basal cell carcinoma_Homo sapiens_hsa052170.54508381
59Selenocompound metabolism_Homo sapiens_hsa004500.53925485
60Hippo signaling pathway_Homo sapiens_hsa043900.50804115
61Protein export_Homo sapiens_hsa030600.50413844
62Glutathione metabolism_Homo sapiens_hsa004800.49090387
63Sulfur relay system_Homo sapiens_hsa041220.48689743
64Primary immunodeficiency_Homo sapiens_hsa053400.44233342
65TGF-beta signaling pathway_Homo sapiens_hsa043500.43902248
66Propanoate metabolism_Homo sapiens_hsa006400.41714628
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41491373
68Alzheimers disease_Homo sapiens_hsa050100.40998244
69Apoptosis_Homo sapiens_hsa042100.40977517
70Notch signaling pathway_Homo sapiens_hsa043300.40803667
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39465382
72Colorectal cancer_Homo sapiens_hsa052100.37971358
73Hedgehog signaling pathway_Homo sapiens_hsa043400.37239312
74Legionellosis_Homo sapiens_hsa051340.36494818
75Hepatitis B_Homo sapiens_hsa051610.33040480
76Alcoholism_Homo sapiens_hsa050340.32933135
77Bladder cancer_Homo sapiens_hsa052190.32547284
78Shigellosis_Homo sapiens_hsa051310.31974400
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28563855
80Carbon metabolism_Homo sapiens_hsa012000.27366725
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26720988
82Measles_Homo sapiens_hsa051620.25859395
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25828525
84Parkinsons disease_Homo sapiens_hsa050120.25070082
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24688875
86Pathways in cancer_Homo sapiens_hsa052000.24476449
87Fructose and mannose metabolism_Homo sapiens_hsa000510.24439128
88Arginine and proline metabolism_Homo sapiens_hsa003300.24213098
89Chronic myeloid leukemia_Homo sapiens_hsa052200.23174226
90N-Glycan biosynthesis_Homo sapiens_hsa005100.22737527
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21723430
92Influenza A_Homo sapiens_hsa051640.20883773
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.20522014
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.20451522
95Fatty acid metabolism_Homo sapiens_hsa012120.19630695
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19152372
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19008274
98HIF-1 signaling pathway_Homo sapiens_hsa040660.18028497
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17758513
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17408971
101Hematopoietic cell lineage_Homo sapiens_hsa046400.17349529
102Arachidonic acid metabolism_Homo sapiens_hsa005900.16968713
103Metabolic pathways_Homo sapiens_hsa011000.16094622
104Arginine biosynthesis_Homo sapiens_hsa002200.15625934
105FoxO signaling pathway_Homo sapiens_hsa040680.15127753
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14647216
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14052874
108Melanoma_Homo sapiens_hsa052180.13393758
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13191107
110Prostate cancer_Homo sapiens_hsa052150.13147178
111Wnt signaling pathway_Homo sapiens_hsa043100.12379947
112Pancreatic cancer_Homo sapiens_hsa052120.12209068
113Adherens junction_Homo sapiens_hsa045200.12052871
114Asthma_Homo sapiens_hsa053100.11412307
115Galactose metabolism_Homo sapiens_hsa000520.10803261
116Viral myocarditis_Homo sapiens_hsa054160.10021707
117Non-small cell lung cancer_Homo sapiens_hsa052230.07942033
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06812885
119Tight junction_Homo sapiens_hsa045300.06220334
120Acute myeloid leukemia_Homo sapiens_hsa052210.05774223
121Regulation of autophagy_Homo sapiens_hsa041400.05405790
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.05103117

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