CDH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.59560026
2desmosome organization (GO:0002934)7.23127403
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.91315159
4interferon-gamma secretion (GO:0072643)5.92651954
5establishment of skin barrier (GO:0061436)4.59154170
6Golgi transport vesicle coating (GO:0048200)4.52055057
7COPI coating of Golgi vesicle (GO:0048205)4.52055057
8regulation of hippo signaling (GO:0035330)4.40603824
9positive regulation of keratinocyte differentiation (GO:0045618)4.39930259
10gap junction assembly (GO:0016264)4.34896875
11intestinal absorption (GO:0050892)4.28876136
12* regulation of water loss via skin (GO:0033561)4.23699371
13* intestinal epithelial cell development (GO:0060576)4.21011100
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.16343119
15negative regulation of keratinocyte proliferation (GO:0010839)4.14274327
16epithelial cell-cell adhesion (GO:0090136)3.96991129
17regulation of posttranscriptional gene silencing (GO:0060147)3.81529920
18regulation of gene silencing by miRNA (GO:0060964)3.81529920
19regulation of gene silencing by RNA (GO:0060966)3.81529920
20intestinal cholesterol absorption (GO:0030299)3.79698815
21regulation of keratinocyte differentiation (GO:0045616)3.74341915
22establishment of apical/basal cell polarity (GO:0035089)3.73352652
23chemical homeostasis within a tissue (GO:0048875)3.68239049
24glandular epithelial cell differentiation (GO:0002067)3.58622931
25L-alpha-amino acid transmembrane transport (GO:1902475)3.57916331
26ear development (GO:0043583)3.54937844
27keratinocyte differentiation (GO:0030216)3.52383157
28* multicellular organismal water homeostasis (GO:0050891)3.52244867
29UDP-N-acetylglucosamine metabolic process (GO:0006047)3.50545627
30calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.46984406
31negative regulation of cell fate specification (GO:0009996)3.46173157
32* tight junction assembly (GO:0070830)3.41962971
33hepatocyte apoptotic process (GO:0097284)3.37732863
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.35509605
35biotin metabolic process (GO:0006768)3.33258609
36regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.33187772
37anterior/posterior axis specification, embryo (GO:0008595)3.32936110
38polarized epithelial cell differentiation (GO:0030859)3.32173806
39ectoderm development (GO:0007398)3.31487452
40keratinocyte proliferation (GO:0043616)3.31350188
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28878965
42regulation of chemokine secretion (GO:0090196)3.28298584
43cell-substrate junction assembly (GO:0007044)3.27456244
44regulation of cell fate specification (GO:0042659)3.27234953
45vitamin transmembrane transport (GO:0035461)3.26139094
46epithelial cell maturation (GO:0002070)3.22633740
47ER overload response (GO:0006983)3.16122434
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.12482266
49epidermal cell differentiation (GO:0009913)3.10501247
50* columnar/cuboidal epithelial cell development (GO:0002066)3.08988044
51positive regulation of epidermis development (GO:0045684)3.05620759
52proline biosynthetic process (GO:0006561)3.05436402
53apical protein localization (GO:0045176)3.04725635
54establishment or maintenance of monopolar cell polarity (GO:0061339)2.98478541
55establishment of monopolar cell polarity (GO:0061162)2.98478541
56negative regulation of cell fate commitment (GO:0010454)2.97825756
57epithelial cell differentiation involved in prostate gland development (GO:0060742)2.97753473
58surfactant homeostasis (GO:0043129)2.96913208
59branching involved in mammary gland duct morphogenesis (GO:0060444)2.96630810
60cardiac right ventricle morphogenesis (GO:0003215)2.94839953
61dorsal/ventral axis specification (GO:0009950)2.94445280
62protein retention in ER lumen (GO:0006621)2.92090600
63* water homeostasis (GO:0030104)2.91348369
64auditory receptor cell differentiation (GO:0042491)2.89848469
65lung lobe morphogenesis (GO:0060463)2.89814357
66endocrine pancreas development (GO:0031018)2.88015393
67paraxial mesoderm development (GO:0048339)2.86008887
68peptide catabolic process (GO:0043171)2.85890161
69regulation of cholesterol homeostasis (GO:2000188)2.84940867
70COPII vesicle coating (GO:0048208)2.84373618
71hormone catabolic process (GO:0042447)2.83796854
72positive regulation of SMAD protein import into nucleus (GO:0060391)2.83670288
73epoxygenase P450 pathway (GO:0019373)2.83589959
74regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.83427616
75keratinization (GO:0031424)2.83353292
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.82881908
77morphogenesis of embryonic epithelium (GO:0016331)2.82256195
78sphingomyelin metabolic process (GO:0006684)2.82123910
79regulation of keratinocyte proliferation (GO:0010837)2.82010422
80positive regulation of hormone metabolic process (GO:0032352)2.80670134
81regulation of cardioblast differentiation (GO:0051890)2.79682696
82prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.77551769
83* trophectodermal cell differentiation (GO:0001829)2.76795024
84mesodermal cell differentiation (GO:0048333)2.76654936
85establishment of tissue polarity (GO:0007164)2.76152894
86establishment of planar polarity (GO:0001736)2.76152894
87mammary gland alveolus development (GO:0060749)2.75217831
88regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.75168883
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74955927
90folic acid-containing compound biosynthetic process (GO:0009396)2.74666832
91positive regulation of epidermal cell differentiation (GO:0045606)2.74248142
92NADH metabolic process (GO:0006734)2.73517813
93amyloid precursor protein catabolic process (GO:0042987)2.72906175
94maternal placenta development (GO:0001893)2.72496110
95epithelial structure maintenance (GO:0010669)2.71777915
96regulation of transforming growth factor beta2 production (GO:0032909)2.71156892
97semaphorin-plexin signaling pathway (GO:0071526)2.70654665
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70134651
99nucleotide-sugar biosynthetic process (GO:0009226)2.69847147
100urea cycle (GO:0000050)2.69212118
101maintenance of gastrointestinal epithelium (GO:0030277)2.68554719
102branching involved in salivary gland morphogenesis (GO:0060445)2.67747176
103regulation of bile acid biosynthetic process (GO:0070857)2.67191703
104ventricular cardiac muscle cell action potential (GO:0086005)2.66927682
105positive regulation of glycoprotein metabolic process (GO:1903020)2.66881633
106branching involved in labyrinthine layer morphogenesis (GO:0060670)2.66817856
107keratinocyte development (GO:0003334)2.66653535
108membrane budding (GO:0006900)2.66541578
109positive regulation of nuclease activity (GO:0032075)2.65111380
110cellular zinc ion homeostasis (GO:0006882)2.64297263
111response to food (GO:0032094)2.63415728
112O-glycan processing (GO:0016266)2.62080619
113regulation of epidermal cell differentiation (GO:0045604)2.61816746
114hippo signaling (GO:0035329)2.61409706
115positive regulation of actin filament depolymerization (GO:0030836)2.60334915
116embryonic foregut morphogenesis (GO:0048617)2.60035393
117skin morphogenesis (GO:0043589)2.59692587
118lung-associated mesenchyme development (GO:0060484)2.58566776
119sphingosine metabolic process (GO:0006670)2.58376113
120positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.58374481
121iron ion import (GO:0097286)2.58338339
122asymmetric protein localization (GO:0008105)2.58182296
123trivalent inorganic anion homeostasis (GO:0072506)2.58162326
124phosphate ion homeostasis (GO:0055062)2.58162326
125regulation of translational fidelity (GO:0006450)2.58151177
126notochord development (GO:0030903)2.57756156
127diol metabolic process (GO:0034311)2.57356533
128cellular glucuronidation (GO:0052695)2.57238557
129establishment of epithelial cell polarity (GO:0090162)2.56842694
130zinc ion transmembrane transport (GO:0071577)2.56225061
131positive regulation of cellular amine metabolic process (GO:0033240)2.55999339
132regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55498756
133urea metabolic process (GO:0019627)2.55122752
134establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.54413116
135cell differentiation involved in embryonic placenta development (GO:0060706)2.53980229
136retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53917486
137sphingoid metabolic process (GO:0046519)2.53859076
138amyloid precursor protein metabolic process (GO:0042982)2.53387017
139apoptotic process involved in morphogenesis (GO:0060561)2.53358578
140activation of Rac GTPase activity (GO:0032863)2.51102207
141primary alcohol catabolic process (GO:0034310)2.50903924
142renal system development (GO:0072001)2.50671444
143positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.50102859
144atrioventricular valve morphogenesis (GO:0003181)2.49338142
145striated muscle atrophy (GO:0014891)2.47888665
146oocyte development (GO:0048599)2.46854304
147epidermis development (GO:0008544)2.46630717
148cellular response to vitamin D (GO:0071305)2.45899866
149purine nucleotide transport (GO:0015865)2.45313895
150regulation of nuclease activity (GO:0032069)2.44887421
151* cell-cell junction assembly (GO:0007043)2.42906128
152establishment or maintenance of apical/basal cell polarity (GO:0035088)2.42483501
153establishment or maintenance of bipolar cell polarity (GO:0061245)2.42483501
154endoplasmic reticulum unfolded protein response (GO:0030968)2.40963158
155protein autoprocessing (GO:0016540)2.39504521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.86652073
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.96144183
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.82167633
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.57388502
5ZNF263_19887448_ChIP-Seq_K562_Human2.53280775
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52204607
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52204607
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52204607
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44618845
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.29095159
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28236774
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.24822918
13AHR_22903824_ChIP-Seq_MCF-7_Human2.24324739
14GATA6_25053715_ChIP-Seq_YYC3_Human2.22289040
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.15597697
16* ESR2_21235772_ChIP-Seq_MCF-7_Human2.13826038
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.10157270
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08941438
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05978498
20KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.02459222
21FOXO3_23340844_ChIP-Seq_DLD1_Human2.01931369
22TP63_17297297_ChIP-ChIP_HaCaT_Human10.0331676
23* GATA4_25053715_ChIP-Seq_YYC3_Human1.94350934
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92491240
25* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.91698326
26AR_21909140_ChIP-Seq_LNCAP_Human1.86293253
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82379760
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80446189
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80446189
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.78538208
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.77814555
32ATF3_27146783_Chip-Seq_COLON_Human1.74774809
33CLOCK_20551151_ChIP-Seq_293T_Human1.74703408
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74641648
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73778557
36E2F7_22180533_ChIP-Seq_HELA_Human1.71394145
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70611469
38* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69299823
39RACK7_27058665_Chip-Seq_MCF-7_Human1.68614509
40* RUNX1_27514584_Chip-Seq_MCF-7_Human1.66981998
41SOX2_20726797_ChIP-Seq_SW620_Human1.64873617
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.64613849
43* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61324204
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57057823
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56238816
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56158932
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55695730
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52973227
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51637429
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49375124
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49149002
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48368507
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46524413
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43608964
55* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.40515335
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39753772
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.39576859
58* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39313505
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39284426
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38458527
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38379034
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38165569
63* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38084141
64ELF5_23300383_ChIP-Seq_T47D_Human1.37841834
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.36300308
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35174345
67* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34127959
68* GATA3_24758297_ChIP-Seq_MCF-7_Human1.33791372
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29033973
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28164121
71* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28103246
72* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24555947
73* KLF5_25053715_ChIP-Seq_YYC3_Human1.24545095
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.24259447
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.23841746
76* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21686590
77* CHD1_26751641_Chip-Seq_LNCaP_Human1.21229082
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20933442
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19602797
80* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18131978
81* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17505241
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14362193
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13973242
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10998073
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10811051
86* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09950901
87* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09534447
88* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06678257
89* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05590251
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05022427
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04336116
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02497280
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.02390571
94* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02382196
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01872273
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01222010
97* RXR_22158963_ChIP-Seq_LIVER_Mouse1.00118244
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.99923989
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99645099
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99181956
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97863295
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97637027
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96855071
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93637455
105CREB1_26743006_Chip-Seq_LNCaP_Human0.91320924
106* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90033944
107UBF1/2_26484160_Chip-Seq_HMECs_Human0.89826714
108* ERG_21242973_ChIP-ChIP_JURKAT_Human0.89606745
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89189911
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.88938396
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87922456
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87715764
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87418504
114KAP1_27257070_Chip-Seq_ESCs_Mouse0.86517233
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85888328
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85152848
117* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84504977
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84126751
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84021355
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81971685
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80720939
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80329802
123* TP63_22573176_ChIP-Seq_HFKS_Human0.80042970
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79050935
125* TP63_23658742_ChIP-Seq_EP156T_Human0.72950646
126TDRD3_21172665_ChIP-Seq_MCF-7_Human0.71913954
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.71210174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.10450205
2MP0000537_abnormal_urethra_morphology3.22843210
3MP0002254_reproductive_system_inflammat3.05920162
4* MP0002796_impaired_skin_barrier2.97567663
5MP0010352_gastrointestinal_tract_polyps2.91043279
6* MP0004264_abnormal_extraembryonic_tissu2.84346166
7MP0003941_abnormal_skin_development2.78977968
8MP0010678_abnormal_skin_adnexa2.65335307
9MP0003705_abnormal_hypodermis_morpholog2.55793562
10MP0002098_abnormal_vibrissa_morphology2.37820185
11MP0001849_ear_inflammation2.33086186
12MP0003453_abnormal_keratinocyte_physiol2.17404166
13MP0003283_abnormal_digestive_organ2.15587896
14MP0000462_abnormal_digestive_system2.07940441
15MP0001666_abnormal_nutrient_absorption2.07497237
16MP0000383_abnormal_hair_follicle2.05111108
17MP0002877_abnormal_melanocyte_morpholog2.02211950
18* MP0005501_abnormal_skin_physiology1.97719880
19MP0000566_synostosis1.86352298
20MP0005076_abnormal_cell_differentiation1.83750465
21* MP0001216_abnormal_epidermal_layer1.83223433
22MP0002060_abnormal_skin_morphology1.82572355
23MP0005409_darkened_coat_color1.81128440
24MP0000579_abnormal_nail_morphology1.81101943
25MP0005275_abnormal_skin_tensile1.80999754
26MP0000467_abnormal_esophagus_morphology1.74960037
27MP0005367_renal/urinary_system_phenotyp1.64613855
28MP0000516_abnormal_urinary_system1.64613855
29MP0003300_gastrointestinal_ulcer1.62475714
30MP0003119_abnormal_digestive_system1.60431522
31* MP0003566_abnormal_cell_adhesion1.56668460
32MP0004381_abnormal_hair_follicle1.56380859
33MP0009053_abnormal_anal_canal1.49286086
34MP0000762_abnormal_tongue_morphology1.48672388
35MP0001346_abnormal_lacrimal_gland1.46875233
36MP0008004_abnormal_stomach_pH1.44113514
37MP0002234_abnormal_pharynx_morphology1.40279553
38MP0006054_spinal_hemorrhage1.39692502
39MP0003183_abnormal_peptide_metabolism1.37712753
40MP0005408_hypopigmentation1.37273076
41* MP0000377_abnormal_hair_follicle1.34094631
42MP0000613_abnormal_salivary_gland1.31732102
43MP0000678_abnormal_parathyroid_gland1.29824784
44MP0004782_abnormal_surfactant_physiolog1.29647987
45MP0009672_abnormal_birth_weight1.28163629
46* MP0004957_abnormal_blastocyst_morpholog1.25298047
47MP0005023_abnormal_wound_healing1.24900587
48MP0000477_abnormal_intestine_morphology1.22358273
49MP0003191_abnormal_cellular_cholesterol1.21684432
50MP0004272_abnormal_basement_membrane1.20937828
51MP0003866_abnormal_defecation1.20355364
52MP0002138_abnormal_hepatobiliary_system1.19246647
53* MP0010771_integument_phenotype1.18983035
54MP0005085_abnormal_gallbladder_physiolo1.18595306
55MP0004947_skin_inflammation1.18504408
56MP0002909_abnormal_adrenal_gland1.17729084
57MP0010030_abnormal_orbit_morphology1.17005566
58MP0003890_abnormal_embryonic-extraembry1.16415142
59MP0000470_abnormal_stomach_morphology1.14054766
60MP0001765_abnormal_ion_homeostasis1.09143092
61MP0000490_abnormal_crypts_of1.07623381
62MP0005220_abnormal_exocrine_pancreas1.07342786
63MP0000647_abnormal_sebaceous_gland1.06199371
64MP0004043_abnormal_pH_regulation1.04014078
65MP0005083_abnormal_biliary_tract1.03543119
66MP0004019_abnormal_vitamin_homeostasis1.03161716
67MP0005377_hearing/vestibular/ear_phenot1.02953076
68MP0003878_abnormal_ear_physiology1.02953076
69MP0004185_abnormal_adipocyte_glucose1.02843011
70MP0003123_paternal_imprinting1.01964159
71MP0000538_abnormal_urinary_bladder1.01336629
72MP0009840_abnormal_foam_cell0.99956360
73MP0002084_abnormal_developmental_patter0.99095459
74MP0003252_abnormal_bile_duct0.98753790
75MP0004233_abnormal_muscle_weight0.98716258
76MP0002139_abnormal_hepatobiliary_system0.98300910
77MP0003868_abnormal_feces_composition0.97129216
78MP0003806_abnormal_nucleotide_metabolis0.96184881
79MP0004858_abnormal_nervous_system0.95878679
80MP0000427_abnormal_hair_cycle0.95709335
81MP0009643_abnormal_urine_homeostasis0.94456887
82* MP0002086_abnormal_extraembryonic_tissu0.92791507
83MP0005248_abnormal_Harderian_gland0.92126764
84* MP0000627_abnormal_mammary_gland0.91233980
85* MP0001881_abnormal_mammary_gland0.89005017
86MP0000367_abnormal_coat/_hair0.86718808
87MP0004197_abnormal_fetal_growth/weight/0.86630851
88* MP0001730_embryonic_growth_arrest0.86041507
89MP0001944_abnormal_pancreas_morphology0.85814685
90MP0002111_abnormal_tail_morphology0.83512026
91MP0005360_urolithiasis0.83197511
92MP0009780_abnormal_chondrocyte_physiolo0.83066492
93MP0002896_abnormal_bone_mineralization0.81579259
94* MP0002085_abnormal_embryonic_tissue0.81444792
95MP0003315_abnormal_perineum_morphology0.81239222
96MP0001727_abnormal_embryo_implantation0.79372958
97* MP0003936_abnormal_reproductive_system0.79075703
98MP0005187_abnormal_penis_morphology0.78988579
99MP0005636_abnormal_mineral_homeostasis0.78936760
100MP0002876_abnormal_thyroid_physiology0.78917094
101MP0002653_abnormal_ependyma_morphology0.78455899
102MP0000350_abnormal_cell_proliferation0.78112454
103* MP0003693_abnormal_embryo_hatching0.77847356
104MP0002166_altered_tumor_susceptibility0.77616241
105MP0003115_abnormal_respiratory_system0.76953458
106MP0002089_abnormal_postnatal_growth/wei0.76597120
107MP0002693_abnormal_pancreas_physiology0.76440854
108MP0002009_preneoplasia0.76088158
109* MP0009931_abnormal_skin_appearance0.75986876
110MP0001873_stomach_inflammation0.75397093
111MP0005365_abnormal_bile_salt0.74560755
112MP0009384_cardiac_valve_regurgitation0.73341511
113* MP0001191_abnormal_skin_condition0.73317486
114MP0001664_abnormal_digestion0.72760611
115* MP0001672_abnormal_embryogenesis/_devel0.72559609
116* MP0005380_embryogenesis_phenotype0.72559609
117MP0003937_abnormal_limbs/digits/tail_de0.72172272
118MP0002277_abnormal_respiratory_mucosa0.71978483
119* MP0010155_abnormal_intestine_physiology0.71537436
120MP0000432_abnormal_head_morphology0.70564446
121MP0002697_abnormal_eye_size0.70466439
122MP0005381_digestive/alimentary_phenotyp0.69407254
123MP0002088_abnormal_embryonic_growth/wei0.68562676
124MP0003638_abnormal_response/metabolism_0.67776370
125MP0008875_abnormal_xenobiotic_pharmacok0.65769678
126MP0005451_abnormal_body_composition0.64781271
127MP0003718_maternal_effect0.61562038
128MP0003984_embryonic_growth_retardation0.59595724
129MP0005257_abnormal_intraocular_pressure0.57405558
130MP0002006_tumorigenesis0.55204055

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.10759603
2Onycholysis (HP:0001806)5.58142366
3Milia (HP:0001056)5.31091214
4Pili torti (HP:0003777)4.65575728
5Fragile nails (HP:0001808)4.60104654
6Plantar hyperkeratosis (HP:0007556)4.17440122
7Woolly hair (HP:0002224)3.89453734
8Atrophic scars (HP:0001075)3.87161792
9Septate vagina (HP:0001153)3.48094543
10Biliary tract neoplasm (HP:0100574)3.44218675
11Lip pit (HP:0100267)3.40210617
12Hyperactive renin-angiotensin system (HP:0000841)3.20013715
13Curly hair (HP:0002212)3.19639106
14Abnormal biliary tract morphology (HP:0012440)3.06423059
15Esophageal atresia (HP:0002032)3.04074146
16Hypoplastic labia majora (HP:0000059)3.02817257
17Nail dystrophy (HP:0008404)3.02510921
18Amelogenesis imperfecta (HP:0000705)3.01901140
19Hypoplasia of dental enamel (HP:0006297)2.95275235
20Abnormality of permanent molar morphology (HP:0011071)2.91773662
21Abnormality of the dental root (HP:0006486)2.91773662
22Taurodontia (HP:0000679)2.91773662
23Abnormal hair laboratory examination (HP:0003328)2.87788821
24Micronodular cirrhosis (HP:0001413)2.77549206
25J-shaped sella turcica (HP:0002680)2.77091057
26Abnormality of the labia majora (HP:0012881)2.69601738
27Abnormality of the distal phalanges of the toes (HP:0010182)2.68099327
28Rectal prolapse (HP:0002035)2.65811533
29Abnormality of molar morphology (HP:0011070)2.63270246
30Abnormality of molar (HP:0011077)2.63270246
31Absent eyelashes (HP:0000561)2.61595745
32Palmoplantar hyperkeratosis (HP:0000972)2.61507872
33Interstitial pulmonary disease (HP:0006530)2.60732540
34Hyperphosphatemia (HP:0002905)2.60002674
35Abnormality of the dental pulp (HP:0006479)2.59179830
36Asymmetry of the thorax (HP:0001555)2.58411630
37Abnormality of chloride homeostasis (HP:0011422)2.57916739
38Abnormal blistering of the skin (HP:0008066)2.57652140
39Palmar hyperkeratosis (HP:0010765)2.55567492
40Abnormality of the salivary glands (HP:0010286)2.54322632
41Abdominal distention (HP:0003270)2.51848816
42Hypotrichosis (HP:0001006)2.50781542
43Flat acetabular roof (HP:0003180)2.47872792
44Sparse lateral eyebrow (HP:0005338)2.46990847
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41358013
46Vascular calcification (HP:0004934)2.40811617
47Gastrointestinal carcinoma (HP:0002672)2.35859149
48Malignant gastrointestinal tract tumors (HP:0006749)2.35859149
49Abnormality of small intestinal villus morphology (HP:0011472)2.31584742
50Villous atrophy (HP:0011473)2.31584742
51Thick nail (HP:0001805)2.30674146
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30258018
53Ileus (HP:0002595)2.29821504
54Trismus (HP:0000211)2.27887994
55Abnormal pancreas size (HP:0012094)2.26266544
56Ependymoma (HP:0002888)2.25062193
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.22984972
58* Abnormality of the gastric mucosa (HP:0004295)2.22298529
59Hyperparathyroidism (HP:0000843)2.21385260
60Esophageal varix (HP:0002040)2.21072499
61Missing ribs (HP:0000921)2.19693491
62Hyperinsulinemic hypoglycemia (HP:0000825)2.19004027
63Dehydration (HP:0001944)2.18369012
64Malnutrition (HP:0004395)2.17861096
65Alopecia of scalp (HP:0002293)2.17331159
66Abnormal hemoglobin (HP:0011902)2.17329800
67Pterygium (HP:0001059)2.12289466
68Natal tooth (HP:0000695)2.11974118
69Gout (HP:0001997)2.11862531
70Abnormal vertebral ossification (HP:0100569)2.11761519
71Bronchomalacia (HP:0002780)2.11489811
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.11343542
73Unilateral renal agenesis (HP:0000122)2.10761107
74Focal segmental glomerulosclerosis (HP:0000097)2.09734230
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07584375
76Gastrointestinal atresia (HP:0002589)2.07440317
77Vertebral clefting (HP:0008428)2.05208389
78Vertebral hypoplasia (HP:0008417)2.05189921
79Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05189921
80Blepharitis (HP:0000498)2.02775829
81Fat malabsorption (HP:0002630)2.02536929
82Symptomatic seizures (HP:0011145)2.01920100
83Concave nail (HP:0001598)2.01039311
84Hyperglycemia (HP:0003074)2.00493882
85Glomerulosclerosis (HP:0000096)2.00484237
86Thin bony cortex (HP:0002753)1.99974436
87Colon cancer (HP:0003003)1.95180305
88Intrahepatic cholestasis (HP:0001406)1.94873664
89Hypoglycemic coma (HP:0001325)1.93758593
90Ankyloglossia (HP:0010296)1.93084430
91Cardiovascular calcification (HP:0011915)1.92412626
92Popliteal pterygium (HP:0009756)1.92264237
93Hypoglycemic seizures (HP:0002173)1.91937378
94Renal salt wasting (HP:0000127)1.88673057
95Stenosis of the external auditory canal (HP:0000402)1.88187757
96Short humerus (HP:0005792)1.86106873
97Ureteral stenosis (HP:0000071)1.85356729
98Shawl scrotum (HP:0000049)1.84466275
99Fragile skin (HP:0001030)1.83675510
100Goiter (HP:0000853)1.83465002
101Abnormality of the axillary hair (HP:0100134)1.83142855
102Abnormality of secondary sexual hair (HP:0009888)1.83142855
103Abnormality of the lacrimal duct (HP:0011481)1.81744592
104Hyperglycinuria (HP:0003108)1.81620521
105Congenital ichthyosiform erythroderma (HP:0007431)1.81007581
106Broad face (HP:0000283)1.80256760
107Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79644188
108Pustule (HP:0200039)1.78991457
109Ureteral obstruction (HP:0006000)1.78934302
110Ventricular tachycardia (HP:0004756)1.78811054
111Spinal cord compression (HP:0002176)1.78718145
112Abnormality of the 1st metacarpal (HP:0010009)1.78442063
113Anonychia (HP:0001798)1.77500459
11411 pairs of ribs (HP:0000878)1.77062682
115Abnormality of renin-angiotensin system (HP:0000847)1.77016489
116Exocrine pancreatic insufficiency (HP:0001738)1.76928628
117Absent eyebrow (HP:0002223)1.76723318
118Late onset (HP:0003584)1.76699379
119Short nail (HP:0001799)1.75546710
120Renal tubular acidosis (HP:0001947)1.74355980
121Tracheal stenosis (HP:0002777)1.74210296
122Labial hypoplasia (HP:0000066)1.74037027
123Aplasia/hypoplasia of the humerus (HP:0006507)1.73512770
124Proximal tubulopathy (HP:0000114)1.73303093
125Abnormal tarsal ossification (HP:0008369)1.72903380
126Chronic bronchitis (HP:0004469)1.71858216
127Abnormality of the labia (HP:0000058)1.71789570
128Urethral obstruction (HP:0000796)1.71471969
129Sparse scalp hair (HP:0002209)1.71227332
130Selective tooth agenesis (HP:0001592)1.71221943
131Aplasia cutis congenita (HP:0001057)1.70745020
132Neonatal death (HP:0003811)1.70714015
133Advanced eruption of teeth (HP:0006288)1.68935455
134Distal lower limb muscle weakness (HP:0009053)1.68773891
135Aplasia/hypoplasia of the uterus (HP:0008684)1.68482945
136Abnormality of nail color (HP:0100643)1.68168724
137Ridged nail (HP:0001807)1.67361062
138Neoplasm of the rectum (HP:0100743)1.66539650
139Sparse eyelashes (HP:0000653)1.66466600
140Absent hair (HP:0002298)1.64979027
141Microglossia (HP:0000171)1.63906700
142Abnormality of proline metabolism (HP:0010907)1.63391641
143Hydroxyprolinuria (HP:0003080)1.63391641
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.62953807
145Widely patent fontanelles and sutures (HP:0004492)1.62768753
146Hoarse voice (HP:0001609)1.62235417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.16565736
2MST43.74922565
3LATS13.17592084
4FRK2.77005930
5MST1R2.70039047
6RPS6KB22.64872993
7SMG12.61818606
8MAP3K22.53287272
9PIK3CA2.44457757
10CDK122.32927402
11MET2.19506827
12FER2.18812680
13MAP2K22.10374121
14PASK2.03189488
15MAP3K121.96303120
16PTK61.92020380
17MAP3K31.86574637
18PTK21.77721771
19MAPK151.72429195
20MAPKAPK31.70056437
21NEK61.67789730
22ERN11.64058343
23EPHB21.63511016
24STK101.60215611
25LMTK21.59577728
26STK241.54197146
27RIPK11.52936548
28TESK11.47592912
29PAK41.47119625
30EIF2AK11.43457297
31PRKCI1.39187767
32STK38L1.35150623
33LRRK21.32905582
34EEF2K1.23537518
35AKT31.21973027
36TTK1.19202115
37PBK1.16165259
38PKN21.09550146
39CDK61.02195211
40PRKG21.01821119
41EPHB11.00757509
42INSRR0.99714379
43TAOK30.96989358
44MAP3K80.96685415
45DDR20.93704288
46STK30.89252687
47WNK40.88552089
48OXSR10.88291502
49TAF10.87742377
50ERBB20.87375656
51FGFR40.87255102
52NME10.86607949
53PDGFRA0.86274862
54TRIB30.86248900
55FLT30.83048143
56NEK10.82396077
57MTOR0.81827584
58AURKB0.81073955
59SIK10.80411529
60MUSK0.80208583
61ERBB40.79090262
62TSSK60.78930064
63EPHA30.78798433
64RPS6KA20.77664427
65SCYL20.77334655
66MAP3K10.76009351
67DYRK1B0.74351382
68MAP3K100.72681465
69CAMK1D0.72246855
70MAP2K10.70385953
71BRD40.70072105
72FGFR10.68355641
73LATS20.67896679
74CDK70.64361497
75RPS6KB10.63737832
76RET0.62291459
77NME20.60925615
78NUAK10.59330093
79DMPK0.59288590
80BCR0.58789318
81CAMK1G0.58630309
82BMX0.58232840
83HIPK20.57848403
84TGFBR10.57446718
85ILK0.57291396
86GSK3A0.52234894
87CHUK0.51856400
88EIF2AK30.51377142
89SIK30.50047115
90ALK0.49241593
91STK380.47575167
92RPS6KA40.46739100
93PDGFRB0.46588512
94KSR20.45580254
95STK390.43592765
96MYLK0.42960898
97TRPM70.42243504
98FGFR20.42236445
99BRSK20.41522343
100MELK0.40683707
101ICK0.39593689
102MAP3K90.38842558
103NEK20.38467930
104TRIM280.38214635
105TESK20.37447862
106YES10.37368055
107PAK20.37169893
108WEE10.36387794
109VRK20.35677107
110PDPK10.34895098
111MATK0.34892074
112TAOK10.34743776
113ACVR1B0.34681647
114AURKA0.34630717
115MAP2K60.32540369
116MAPKAPK20.32513824
117DYRK30.32364502
118CDC42BPA0.32119804
119CAMK2G0.32022578
120CAMK2D0.31765279
121RPS6KA10.30204800
122FGFR30.30092460
123SGK30.29268231
124AKT20.28090733
125* CSNK1E0.27802532
126IRAK30.27006915
127TTN0.26213652
128NTRK10.26057004
129PRKCZ0.25040663
130CHEK10.24941876
131PAK30.24373523
132PLK10.23124790
133PRKD30.22113947
134PRKAA20.21771411
135MAPK10.20892162
136SRPK10.20653695
137ATM0.18838389

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.04782638
2Sulfur metabolism_Homo sapiens_hsa009202.94249407
3Fat digestion and absorption_Homo sapiens_hsa049752.72389398
4Tight junction_Homo sapiens_hsa045302.39862986
5Mineral absorption_Homo sapiens_hsa049782.24154867
6* Adherens junction_Homo sapiens_hsa045202.16425520
7* Hippo signaling pathway_Homo sapiens_hsa043901.94325055
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94187489
9Basal cell carcinoma_Homo sapiens_hsa052171.86274976
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83332987
11Protein digestion and absorption_Homo sapiens_hsa049741.77223668
12Arginine biosynthesis_Homo sapiens_hsa002201.76715819
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74577803
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71587658
15Selenocompound metabolism_Homo sapiens_hsa004501.70563704
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.69221897
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.61387120
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59910466
19Renin-angiotensin system_Homo sapiens_hsa046141.55884841
20Folate biosynthesis_Homo sapiens_hsa007901.52065833
21ECM-receptor interaction_Homo sapiens_hsa045121.51445099
22Histidine metabolism_Homo sapiens_hsa003401.45798048
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43641454
24Glutathione metabolism_Homo sapiens_hsa004801.43076743
25Small cell lung cancer_Homo sapiens_hsa052221.41588324
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41414218
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36984546
28Pancreatic secretion_Homo sapiens_hsa049721.33748838
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.32696531
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.30429695
31* Bladder cancer_Homo sapiens_hsa052191.27276741
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22513525
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22484193
34Vitamin digestion and absorption_Homo sapiens_hsa049771.21840779
35Hedgehog signaling pathway_Homo sapiens_hsa043401.20953440
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18085200
37Galactose metabolism_Homo sapiens_hsa000521.17846199
38Arginine and proline metabolism_Homo sapiens_hsa003301.16883022
39Linoleic acid metabolism_Homo sapiens_hsa005911.15249271
40Proteoglycans in cancer_Homo sapiens_hsa052051.12703879
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11936672
42Steroid biosynthesis_Homo sapiens_hsa001001.09441245
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08880852
44p53 signaling pathway_Homo sapiens_hsa041151.06629546
45TGF-beta signaling pathway_Homo sapiens_hsa043501.06228138
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05093390
47AMPK signaling pathway_Homo sapiens_hsa041521.01993905
48Fructose and mannose metabolism_Homo sapiens_hsa000511.01557703
49Chemical carcinogenesis_Homo sapiens_hsa052041.01197656
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97365854
51MicroRNAs in cancer_Homo sapiens_hsa052060.97271170
52Fatty acid metabolism_Homo sapiens_hsa012120.95310794
53beta-Alanine metabolism_Homo sapiens_hsa004100.93635118
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92591576
55PPAR signaling pathway_Homo sapiens_hsa033200.91118384
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91107946
57Fatty acid biosynthesis_Homo sapiens_hsa000610.90804036
58Caffeine metabolism_Homo sapiens_hsa002320.90022394
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89445849
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89259371
61Phenylalanine metabolism_Homo sapiens_hsa003600.88742860
62* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88683357
63* Thyroid cancer_Homo sapiens_hsa052160.88441486
64Thyroid hormone synthesis_Homo sapiens_hsa049180.88335453
65Tryptophan metabolism_Homo sapiens_hsa003800.87859383
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87135156
67Nitrogen metabolism_Homo sapiens_hsa009100.86418820
68Sphingolipid metabolism_Homo sapiens_hsa006000.85964371
69Bile secretion_Homo sapiens_hsa049760.85240392
70Amoebiasis_Homo sapiens_hsa051460.85217844
71Focal adhesion_Homo sapiens_hsa045100.85052219
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84844691
73Notch signaling pathway_Homo sapiens_hsa043300.84143896
74One carbon pool by folate_Homo sapiens_hsa006700.84081827
75Vibrio cholerae infection_Homo sapiens_hsa051100.83618412
76Inositol phosphate metabolism_Homo sapiens_hsa005620.83483040
77Insulin signaling pathway_Homo sapiens_hsa049100.82433324
78Antigen processing and presentation_Homo sapiens_hsa046120.79944713
79Starch and sucrose metabolism_Homo sapiens_hsa005000.79530048
80Other glycan degradation_Homo sapiens_hsa005110.79469023
81RNA transport_Homo sapiens_hsa030130.78306162
82Fatty acid elongation_Homo sapiens_hsa000620.77351757
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75718723
84Vitamin B6 metabolism_Homo sapiens_hsa007500.75662422
85Prostate cancer_Homo sapiens_hsa052150.71473918
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70884436
87Ribosome_Homo sapiens_hsa030100.69855746
88Hepatitis C_Homo sapiens_hsa051600.68834686
89Biosynthesis of amino acids_Homo sapiens_hsa012300.68751510
90Glucagon signaling pathway_Homo sapiens_hsa049220.68026828
91Arachidonic acid metabolism_Homo sapiens_hsa005900.67357339
92ErbB signaling pathway_Homo sapiens_hsa040120.66732825
93Insulin resistance_Homo sapiens_hsa049310.66404167
94Lysine degradation_Homo sapiens_hsa003100.65925274
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64605734
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63280952
97Wnt signaling pathway_Homo sapiens_hsa043100.61180784
98Toxoplasmosis_Homo sapiens_hsa051450.60748975
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59240000
100* Pathways in cancer_Homo sapiens_hsa052000.58163031
101ABC transporters_Homo sapiens_hsa020100.56834818
102Choline metabolism in cancer_Homo sapiens_hsa052310.55835860
103N-Glycan biosynthesis_Homo sapiens_hsa005100.55799905
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.55766774
105Carbon metabolism_Homo sapiens_hsa012000.55273995
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55002661
107Retinol metabolism_Homo sapiens_hsa008300.53500767
108Fatty acid degradation_Homo sapiens_hsa000710.52714115
109Renal cell carcinoma_Homo sapiens_hsa052110.52479135
110Estrogen signaling pathway_Homo sapiens_hsa049150.51990980
111Pyruvate metabolism_Homo sapiens_hsa006200.51720566
112Protein export_Homo sapiens_hsa030600.51644895
113* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50935223
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50803783
115Dorso-ventral axis formation_Homo sapiens_hsa043200.50683721
116Viral carcinogenesis_Homo sapiens_hsa052030.49883364
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.48173106
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46632487
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45804875
120* Endometrial cancer_Homo sapiens_hsa052130.43487117
121Glycerolipid metabolism_Homo sapiens_hsa005610.43443814
122mTOR signaling pathway_Homo sapiens_hsa041500.43013181
123Legionellosis_Homo sapiens_hsa051340.42711372
124Melanogenesis_Homo sapiens_hsa049160.42223970
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41398288
126Cell cycle_Homo sapiens_hsa041100.37996774
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.37595403
128Chronic myeloid leukemia_Homo sapiens_hsa052200.35823887
129HTLV-I infection_Homo sapiens_hsa051660.35668080
130Prolactin signaling pathway_Homo sapiens_hsa049170.34874291
131Apoptosis_Homo sapiens_hsa042100.34030180
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34005871
133Type II diabetes mellitus_Homo sapiens_hsa049300.33551367
134Pentose phosphate pathway_Homo sapiens_hsa000300.33421142
135Tyrosine metabolism_Homo sapiens_hsa003500.33162272
136Mismatch repair_Homo sapiens_hsa034300.31939312

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