CDH12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.27981182
2neuron cell-cell adhesion (GO:0007158)6.03441566
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.01297677
4presynaptic membrane assembly (GO:0097105)5.99311886
5vocalization behavior (GO:0071625)5.71445665
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.64601894
7protein localization to synapse (GO:0035418)5.61165743
8glutamate secretion (GO:0014047)5.56361299
9synaptic vesicle exocytosis (GO:0016079)5.48629578
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47585679
11presynaptic membrane organization (GO:0097090)5.42562942
12neurotransmitter-gated ion channel clustering (GO:0072578)5.28920621
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22542364
14regulation of glutamate receptor signaling pathway (GO:1900449)5.22127061
15behavioral response to nicotine (GO:0035095)5.14695293
16regulation of synaptic vesicle exocytosis (GO:2000300)5.08582922
17neuronal action potential propagation (GO:0019227)4.99691091
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.92297965
19glutamate receptor signaling pathway (GO:0007215)4.86820730
20synaptic transmission, glutamatergic (GO:0035249)4.80352757
21postsynaptic membrane organization (GO:0001941)4.78663815
22neuron-neuron synaptic transmission (GO:0007270)4.75363614
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.61858173
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.56012577
25pyrimidine nucleobase catabolic process (GO:0006208)4.55152366
26regulation of synaptic vesicle transport (GO:1902803)4.52537149
27positive regulation of synapse maturation (GO:0090129)4.47815877
28cerebellar granule cell differentiation (GO:0021707)4.46593880
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.42460357
30neuron recognition (GO:0008038)4.11725707
31long-term synaptic potentiation (GO:0060291)4.11294982
32neurotransmitter secretion (GO:0007269)4.11246606
33positive regulation of neurotransmitter secretion (GO:0001956)4.04110887
34startle response (GO:0001964)4.02192684
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01023362
36locomotory exploration behavior (GO:0035641)4.00022151
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98894270
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98762594
39response to histamine (GO:0034776)3.98135491
40response to pheromone (GO:0019236)3.97454917
41regulation of postsynaptic membrane potential (GO:0060078)3.93838222
42axonal fasciculation (GO:0007413)3.90287398
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.87249925
44synaptic vesicle maturation (GO:0016188)3.84307778
45nucleobase catabolic process (GO:0046113)3.84199399
46retinal ganglion cell axon guidance (GO:0031290)3.77377981
47regulation of synapse maturation (GO:0090128)3.77219414
48protein polyglutamylation (GO:0018095)3.74438741
49positive regulation of synapse assembly (GO:0051965)3.69806540
50positive regulation of membrane potential (GO:0045838)3.64585051
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63599874
52regulation of glutamate secretion (GO:0014048)3.60915740
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59659500
54regulation of synaptic plasticity (GO:0048167)3.56218761
55epithelial cilium movement (GO:0003351)3.55131950
56protein localization to cilium (GO:0061512)3.53673217
57negative regulation of dendrite morphogenesis (GO:0050774)3.52205519
58regulation of neurotransmitter secretion (GO:0046928)3.52014810
59positive regulation of neurotransmitter transport (GO:0051590)3.49420614
60cerebellar Purkinje cell differentiation (GO:0021702)3.47139464
61regulation of neuronal synaptic plasticity (GO:0048168)3.45379477
62exploration behavior (GO:0035640)3.45045534
63long-term memory (GO:0007616)3.40173014
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37199921
65mechanosensory behavior (GO:0007638)3.34662375
66neurotransmitter transport (GO:0006836)3.34137046
67behavioral response to cocaine (GO:0048148)3.33499262
68regulation of action potential (GO:0098900)3.31396159
69intraciliary transport (GO:0042073)3.30890905
70serotonin metabolic process (GO:0042428)3.29172587
71synaptic vesicle endocytosis (GO:0048488)3.28306403
72membrane depolarization (GO:0051899)3.26208090
73transferrin transport (GO:0033572)3.25319355
74positive regulation of action potential (GO:0045760)3.23956405
75nonmotile primary cilium assembly (GO:0035058)3.23488732
76negative regulation of amino acid transport (GO:0051956)3.20819449
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20517546
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20148915
79ATP hydrolysis coupled proton transport (GO:0015991)3.20148915
80regulation of synapse assembly (GO:0051963)3.18641775
81negative regulation of dendrite development (GO:2000171)3.16951360
82behavioral fear response (GO:0001662)3.15902156
83behavioral defense response (GO:0002209)3.15902156
84L-fucose catabolic process (GO:0042355)3.15554899
85fucose catabolic process (GO:0019317)3.15554899
86L-fucose metabolic process (GO:0042354)3.15554899
87positive regulation of synaptic transmission (GO:0050806)3.15506043
88regulation of vesicle fusion (GO:0031338)3.15243825
89retinal cone cell development (GO:0046549)3.14489050
90fear response (GO:0042596)3.13238878
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13028061
92gamma-aminobutyric acid transport (GO:0015812)3.08272601
93synaptic transmission (GO:0007268)3.07963877
94regulation of neurotransmitter transport (GO:0051588)3.07525089
95dendritic spine morphogenesis (GO:0060997)3.06794603
96detection of light stimulus involved in sensory perception (GO:0050962)3.05028006
97detection of light stimulus involved in visual perception (GO:0050908)3.05028006
98membrane depolarization during action potential (GO:0086010)3.04967783
99ferric iron transport (GO:0015682)3.03802596
100trivalent inorganic cation transport (GO:0072512)3.03802596
101regulation of synaptic transmission (GO:0050804)3.03520056
102regulation of neurotransmitter levels (GO:0001505)3.01817094
103learning (GO:0007612)3.00859745
104membrane assembly (GO:0071709)2.99880244
105tachykinin receptor signaling pathway (GO:0007217)2.99772565
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99547566
107auditory behavior (GO:0031223)2.98159148
108cornea development in camera-type eye (GO:0061303)2.97507546
109urinary tract smooth muscle contraction (GO:0014848)2.97030018
110cochlea development (GO:0090102)2.97025074
111detection of calcium ion (GO:0005513)2.97008086
112regulation of synaptic transmission, GABAergic (GO:0032228)2.96679393
113membrane hyperpolarization (GO:0060081)2.95797411
114transmission of nerve impulse (GO:0019226)2.95568448
115synapse assembly (GO:0007416)2.95484114
116regulation of respiratory system process (GO:0044065)2.93846424
117regulation of voltage-gated calcium channel activity (GO:1901385)2.93365852
118opioid receptor signaling pathway (GO:0038003)2.93205671
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93124165
120regulation of dendritic spine morphogenesis (GO:0061001)2.90911420
121regulation of dendritic spine development (GO:0060998)2.89767456
122cilium movement (GO:0003341)2.86248888
123establishment of mitochondrion localization (GO:0051654)2.85858680
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84564594
125platelet dense granule organization (GO:0060155)2.83132033
126behavioral response to ethanol (GO:0048149)2.80562957
127photoreceptor cell maintenance (GO:0045494)2.77718097
128inositol phosphate catabolic process (GO:0071545)2.77587998
129neuronal action potential (GO:0019228)2.74596595
130primary amino compound metabolic process (GO:1901160)2.73666997
131indolalkylamine metabolic process (GO:0006586)2.72426900
132piRNA metabolic process (GO:0034587)2.70909170
133negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70349723
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.68323282
135mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.68323282
136regulation of cilium movement (GO:0003352)2.68312089
137axoneme assembly (GO:0035082)2.67772192
138phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67689776
139inositol phosphate dephosphorylation (GO:0046855)2.67689776
140short-term memory (GO:0007614)2.64025926
141synaptic transmission, cholinergic (GO:0007271)2.63934922
142regulation of feeding behavior (GO:0060259)2.63094965
143cullin deneddylation (GO:0010388)2.62451385
144water-soluble vitamin biosynthetic process (GO:0042364)2.62175676
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61142025
146kynurenine metabolic process (GO:0070189)2.59874604
147establishment of protein localization to Golgi (GO:0072600)2.58195036
148proline transport (GO:0015824)2.57027016
149negative regulation of axon guidance (GO:1902668)2.55869722
150reflex (GO:0060004)2.55099235
151sympathetic nervous system development (GO:0048485)2.54767222
152cilium morphogenesis (GO:0060271)2.53480877
153photoreceptor cell development (GO:0042461)2.53302058
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53114837
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.53114837
156NADH dehydrogenase complex assembly (GO:0010257)2.53114837
157protein complex biogenesis (GO:0070271)2.51510585
158calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50999400
159regulation of microtubule-based movement (GO:0060632)2.50638187
160cilium organization (GO:0044782)2.48722286
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46722682
162cilium assembly (GO:0042384)2.45885837
163preassembly of GPI anchor in ER membrane (GO:0016254)2.45711734
164mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.45502757
165tryptophan catabolic process (GO:0006569)2.45274185
166indole-containing compound catabolic process (GO:0042436)2.45274185
167indolalkylamine catabolic process (GO:0046218)2.45274185
168protein targeting to Golgi (GO:0000042)2.43342934
169glycosphingolipid biosynthetic process (GO:0006688)2.42956799
170establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41469269
171mitochondrion transport along microtubule (GO:0047497)2.41469269
172negative regulation of telomere maintenance (GO:0032205)2.40621563
173cilium or flagellum-dependent cell motility (GO:0001539)2.39257602
174DNA methylation involved in gamete generation (GO:0043046)2.39113853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82271299
2* GBX2_23144817_ChIP-Seq_PC3_Human5.03888688
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06603651
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95111338
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90424492
6TAF15_26573619_Chip-Seq_HEK293_Human2.83259705
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56789229
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54390730
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.47178757
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45880323
11REST_21632747_ChIP-Seq_MESCs_Mouse2.42388634
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41132661
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41132661
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39432745
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37386175
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36209719
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36041620
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35574200
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31942016
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22689800
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19641687
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15367423
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08194163
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08144597
25P300_19829295_ChIP-Seq_ESCs_Human2.03279718
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00134916
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.99110745
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98814247
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.94047716
30FUS_26573619_Chip-Seq_HEK293_Human1.90559559
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89753240
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.89016588
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88661968
34DROSHA_22980978_ChIP-Seq_HELA_Human1.87404754
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87322181
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.86729352
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86657907
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.83293169
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77184156
40AR_21572438_ChIP-Seq_LNCaP_Human1.75241387
41VDR_22108803_ChIP-Seq_LS180_Human1.75089966
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72352370
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.67206850
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.67086842
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.65194576
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64269982
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61191119
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57119127
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55526936
50IRF1_19129219_ChIP-ChIP_H3396_Human1.55074817
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53160202
52* AR_25329375_ChIP-Seq_VCAP_Human1.50346704
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47746246
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46922328
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44004928
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42933402
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42582010
58RNF2_27304074_Chip-Seq_NSC_Mouse1.40504681
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39627779
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39262441
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37150507
62TP53_22573176_ChIP-Seq_HFKS_Human1.37049748
63* CBP_20019798_ChIP-Seq_JUKART_Human1.36939067
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36939067
65* STAT3_23295773_ChIP-Seq_U87_Human1.35699620
66* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32534513
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31902483
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31477839
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30214420
70* TCF4_23295773_ChIP-Seq_U87_Human1.29322310
71* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29227175
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27014657
73ER_23166858_ChIP-Seq_MCF-7_Human1.25322678
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24687678
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24475707
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.24203399
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22548817
78ZNF274_21170338_ChIP-Seq_K562_Hela1.22068113
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.21345066
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20817227
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20817227
82* AHR_22903824_ChIP-Seq_MCF-7_Human1.19396407
83TCF4_22108803_ChIP-Seq_LS180_Human1.19121688
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18083904
85IGF1R_20145208_ChIP-Seq_DFB_Human1.17441420
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.17152170
87RUNX2_22187159_ChIP-Seq_PCA_Human1.16563621
88TP53_18474530_ChIP-ChIP_U2OS_Human1.15558707
89* JUN_21703547_ChIP-Seq_K562_Human1.14917250
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13814026
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13431315
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12314253
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12231944
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11837752
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.11614005
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.11610507
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11122985
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11085665
99AR_19668381_ChIP-Seq_PC3_Human1.10819931
100SOX2_19829295_ChIP-Seq_ESCs_Human1.10719000
101NANOG_19829295_ChIP-Seq_ESCs_Human1.10719000
102* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10312383
103EWS_26573619_Chip-Seq_HEK293_Human1.09678418
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07198825
105TP53_16413492_ChIP-PET_HCT116_Human1.07174985
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07074984
107* SOX9_26525672_Chip-Seq_HEART_Mouse1.05265585
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.05114942
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04859845
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04457113
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04132368
112KDM2B_26808549_Chip-Seq_REH_Human1.03685077
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.03548933
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02517722
115* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01994788
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01653730
117MYC_18940864_ChIP-ChIP_HL60_Human1.01390714
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01239448
119P53_22387025_ChIP-Seq_ESCs_Mouse1.01220282
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00748521
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00096535
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.99884389
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.99680704
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99261981
125BCAT_22108803_ChIP-Seq_LS180_Human0.98576731
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96560515
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.95900730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.23902651
2MP0004859_abnormal_synaptic_plasticity5.30807679
3MP0003635_abnormal_synaptic_transmissio3.94475023
4MP0009745_abnormal_behavioral_response3.59106034
5MP0001968_abnormal_touch/_nociception3.53511696
6MP0004270_analgesia3.35313246
7MP0009046_muscle_twitch3.32421753
8MP0002064_seizures3.29828896
9MP0002063_abnormal_learning/memory/cond3.21033579
10MP0002736_abnormal_nociception_after3.05315861
11MP0002572_abnormal_emotion/affect_behav2.97732633
12MP0002822_catalepsy2.88198527
13MP0000569_abnormal_digit_pigmentation2.79537577
14MP0002735_abnormal_chemical_nociception2.78187606
15MP0002638_abnormal_pupillary_reflex2.77272736
16MP0002272_abnormal_nervous_system2.63926245
17MP0002734_abnormal_mechanical_nocicepti2.48627892
18MP0001486_abnormal_startle_reflex2.40158003
19MP0001440_abnormal_grooming_behavior2.33101934
20MP0002067_abnormal_sensory_capabilities2.25841152
21MP0001501_abnormal_sleep_pattern2.25796380
22MP0003879_abnormal_hair_cell2.21906583
23MP0009780_abnormal_chondrocyte_physiolo2.19970240
24MP0006072_abnormal_retinal_apoptosis2.15456037
25MP0003787_abnormal_imprinting2.07691680
26MP0005423_abnormal_somatic_nervous2.04694410
27MP0001188_hyperpigmentation1.99609586
28MP0006276_abnormal_autonomic_nervous1.84106658
29MP0005646_abnormal_pituitary_gland1.84012842
30MP0002733_abnormal_thermal_nociception1.81626321
31MP0003011_delayed_dark_adaptation1.79993145
32MP0001970_abnormal_pain_threshold1.79269069
33MP0005386_behavior/neurological_phenoty1.75654600
34MP0004924_abnormal_behavior1.75654600
35MP0001984_abnormal_olfaction1.72373701
36MP0002557_abnormal_social/conspecific_i1.71200293
37MP0002184_abnormal_innervation1.71106997
38MP0000778_abnormal_nervous_system1.69897517
39MP0002837_dystrophic_cardiac_calcinosis1.63619021
40MP0002876_abnormal_thyroid_physiology1.62289519
41MP0001529_abnormal_vocalization1.52635561
42MP0004142_abnormal_muscle_tone1.52399388
43MP0003195_calcinosis1.51774714
44MP0008569_lethality_at_weaning1.49884050
45MP0008789_abnormal_olfactory_epithelium1.48254346
46MP0003122_maternal_imprinting1.42657622
47MP0002938_white_spotting1.40305548
48MP0003329_amyloid_beta_deposits1.38354585
49MP0004811_abnormal_neuron_physiology1.38324250
50MP0001502_abnormal_circadian_rhythm1.33787215
51MP0004133_heterotaxia1.33607870
52MP0005084_abnormal_gallbladder_morpholo1.32359817
53MP0002066_abnormal_motor_capabilities/c1.30808629
54MP0002882_abnormal_neuron_morphology1.29392651
55MP0002928_abnormal_bile_duct1.28641146
56MP0001905_abnormal_dopamine_level1.26816507
57MP0002160_abnormal_reproductive_system1.26226941
58MP0005551_abnormal_eye_electrophysiolog1.24345556
59MP0001986_abnormal_taste_sensitivity1.23390768
60MP0000955_abnormal_spinal_cord1.23059035
61MP0003633_abnormal_nervous_system1.19356007
62MP0005171_absent_coat_pigmentation1.17108166
63MP0000427_abnormal_hair_cycle1.16422977
64MP0002234_abnormal_pharynx_morphology1.14880135
65MP0010386_abnormal_urinary_bladder1.13012495
66MP0002909_abnormal_adrenal_gland1.07758707
67MP0005085_abnormal_gallbladder_physiolo1.07218567
68MP0004742_abnormal_vestibular_system1.06792940
69MP0002163_abnormal_gland_morphology1.06597509
70MP0000751_myopathy1.05413374
71MP0001963_abnormal_hearing_physiology1.03208647
72MP0003631_nervous_system_phenotype0.99726450
73MP0005195_abnormal_posterior_eye0.97115062
74MP0000566_synostosis0.96063628
75MP0005379_endocrine/exocrine_gland_phen0.95088974
76MP0002152_abnormal_brain_morphology0.94943062
77MP0008875_abnormal_xenobiotic_pharmacok0.94905086
78MP0002229_neurodegeneration0.91601085
79MP0005645_abnormal_hypothalamus_physiol0.91481752
80MP0004145_abnormal_muscle_electrophysio0.90914945
81MP0003718_maternal_effect0.90384501
82MP0005389_reproductive_system_phenotype0.88444587
83MP0008872_abnormal_physiological_respon0.88013881
84MP0003137_abnormal_impulse_conducting0.86470640
85MP0002102_abnormal_ear_morphology0.86293533
86MP0002069_abnormal_eating/drinking_beha0.85734647
87MP0004484_altered_response_of0.85590481
88MP0001293_anophthalmia0.84698511
89MP0000372_irregular_coat_pigmentation0.84219092
90MP0000049_abnormal_middle_ear0.83413092
91MP0004085_abnormal_heartbeat0.82764180
92MP0001485_abnormal_pinna_reflex0.82687876
93MP0004858_abnormal_nervous_system0.82134819
94MP0004215_abnormal_myocardial_fiber0.81648960
95MP0008004_abnormal_stomach_pH0.81335523
96MP0001664_abnormal_digestion0.81192892
97MP0008877_abnormal_DNA_methylation0.81089121
98MP0000631_abnormal_neuroendocrine_gland0.79450853
99MP0005410_abnormal_fertilization0.79265483
100MP0005391_vision/eye_phenotype0.77965545
101MP0008874_decreased_physiological_sensi0.77021979
102MP0003890_abnormal_embryonic-extraembry0.76976379
103MP0008775_abnormal_heart_ventricle0.76303612
104MP0002752_abnormal_somatic_nervous0.74610690
105MP0004885_abnormal_endolymph0.71499996
106MP0003121_genomic_imprinting0.71161858
107MP0000026_abnormal_inner_ear0.70002178
108MP0004233_abnormal_muscle_weight0.69114487
109MP0005535_abnormal_body_temperature0.65145759
110MP0006292_abnormal_olfactory_placode0.64906656
111MP0004043_abnormal_pH_regulation0.63606545
112MP0003123_paternal_imprinting0.62967215
113MP0005409_darkened_coat_color0.61749001
114MP0001943_abnormal_respiration0.58559723
115MP0003183_abnormal_peptide_metabolism0.57711160
116MP0005499_abnormal_olfactory_system0.57375454
117MP0005394_taste/olfaction_phenotype0.57375454
118MP0003632_abnormal_nervous_system0.57072531
119MP0010770_preweaning_lethality0.55837793
120MP0002082_postnatal_lethality0.55837793
121MP0001177_atelectasis0.54692437
122MP0003646_muscle_fatigue0.53641721
123MP0000604_amyloidosis0.53308728
124MP0002751_abnormal_autonomic_nervous0.53287447
125MP0010769_abnormal_survival0.51551408
126MP0005253_abnormal_eye_physiology0.51463025
127MP0002653_abnormal_ependyma_morphology0.50293910
128MP0010768_mortality/aging0.49063555
129MP0003136_yellow_coat_color0.47150246
130MP0003956_abnormal_body_size0.45867878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.53255234
2Hyperventilation (HP:0002883)7.11280056
3Epileptic encephalopathy (HP:0200134)6.91851562
4Atonic seizures (HP:0010819)6.32225711
5Focal seizures (HP:0007359)5.73054387
6Febrile seizures (HP:0002373)5.49259539
7Absence seizures (HP:0002121)5.02595205
8Broad-based gait (HP:0002136)4.92086107
9Dialeptic seizures (HP:0011146)4.72641215
10Myokymia (HP:0002411)4.06211511
11Generalized tonic-clonic seizures (HP:0002069)4.02900175
12Pancreatic cysts (HP:0001737)4.01906671
13Gaze-evoked nystagmus (HP:0000640)4.01624559
14Protruding tongue (HP:0010808)4.01150743
15Progressive cerebellar ataxia (HP:0002073)3.89346297
16Abnormality of midbrain morphology (HP:0002418)3.88743878
17Molar tooth sign on MRI (HP:0002419)3.88743878
18True hermaphroditism (HP:0010459)3.76483843
19Pancreatic fibrosis (HP:0100732)3.66081030
20Visual hallucinations (HP:0002367)3.65317724
21Nephronophthisis (HP:0000090)3.64282507
22Drooling (HP:0002307)3.53800246
23Excessive salivation (HP:0003781)3.53800246
24Poor eye contact (HP:0000817)3.46076696
25Amblyopia (HP:0000646)3.37535005
26Epileptiform EEG discharges (HP:0011182)3.25639714
27Chronic hepatic failure (HP:0100626)3.24213376
28Limb dystonia (HP:0002451)3.17602025
29Congenital stationary night blindness (HP:0007642)3.13735445
30Absent speech (HP:0001344)3.09378215
31Inability to walk (HP:0002540)3.03607957
32Fair hair (HP:0002286)3.02770305
33Abnormality of the renal medulla (HP:0100957)3.01608551
34Abnormal hair whorl (HP:0010721)3.00974910
35Impaired social interactions (HP:0000735)2.99136868
36Abnormal social behavior (HP:0012433)2.99136868
37Dysmetric saccades (HP:0000641)2.95694137
38Truncal ataxia (HP:0002078)2.91555570
39Cystic liver disease (HP:0006706)2.90227959
40Blue irides (HP:0000635)2.87535957
41Dysdiadochokinesis (HP:0002075)2.83332900
42Type II lissencephaly (HP:0007260)2.82247389
43EEG with generalized epileptiform discharges (HP:0011198)2.80216039
44Generalized hypopigmentation of hair (HP:0011358)2.75459871
45Hypothermia (HP:0002045)2.69808246
46Gait imbalance (HP:0002141)2.66631996
47Abnormal drinking behavior (HP:0030082)2.60062039
48Polydipsia (HP:0001959)2.60062039
49Tubulointerstitial nephritis (HP:0001970)2.59571704
50Abnormal eating behavior (HP:0100738)2.58932695
51Polyphagia (HP:0002591)2.58918501
52Abnormality of the renal cortex (HP:0011035)2.56061816
53Impaired vibration sensation in the lower limbs (HP:0002166)2.53907932
54Medial flaring of the eyebrow (HP:0010747)2.52892109
55Abolished electroretinogram (ERG) (HP:0000550)2.46095771
56Dysmetria (HP:0001310)2.44080052
57Hypsarrhythmia (HP:0002521)2.42569554
58Sclerocornea (HP:0000647)2.42320967
59Impaired smooth pursuit (HP:0007772)2.39518002
60Tubular atrophy (HP:0000092)2.39334441
61Congenital primary aphakia (HP:0007707)2.38563722
62Sensory axonal neuropathy (HP:0003390)2.37914308
63Scanning speech (HP:0002168)2.37760374
64Abnormality of salivation (HP:0100755)2.37635163
65Hyperthyroidism (HP:0000836)2.36799046
66Acute necrotizing encephalopathy (HP:0006965)2.34747066
67Status epilepticus (HP:0002133)2.33540604
68Attenuation of retinal blood vessels (HP:0007843)2.33077428
69Bony spicule pigmentary retinopathy (HP:0007737)2.32929111
70Colon cancer (HP:0003003)2.29242478
71Fetal akinesia sequence (HP:0001989)2.28028655
72Nephrogenic diabetes insipidus (HP:0009806)2.27103814
73Urinary bladder sphincter dysfunction (HP:0002839)2.26616730
74Pachygyria (HP:0001302)2.25115200
75Abnormal respiratory epithelium morphology (HP:0012253)2.23527206
76Abnormal respiratory motile cilium morphology (HP:0005938)2.23527206
77Stereotypic behavior (HP:0000733)2.23471069
78Abnormality of the labia minora (HP:0012880)2.23427144
79Abnormality of the lower motor neuron (HP:0002366)2.23398144
80Thickened helices (HP:0000391)2.23368622
81Acute encephalopathy (HP:0006846)2.22923551
82Retinal dysplasia (HP:0007973)2.22224537
83Poor suck (HP:0002033)2.21389922
84Lissencephaly (HP:0001339)2.20033038
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.18367397
86Increased CSF lactate (HP:0002490)2.18255346
87Abnormal rod and cone electroretinograms (HP:0008323)2.17212068
88Progressive macrocephaly (HP:0004481)2.15874037
89Clumsiness (HP:0002312)2.15277522
90Postaxial hand polydactyly (HP:0001162)2.14905453
91Abnormal mitochondria in muscle tissue (HP:0008316)2.14146317
92Hemiparesis (HP:0001269)2.13430422
93Genetic anticipation (HP:0003743)2.13030473
94Anencephaly (HP:0002323)2.12342038
95Renal cortical cysts (HP:0000803)2.10303574
96Progressive inability to walk (HP:0002505)2.10041635
97Generalized myoclonic seizures (HP:0002123)2.09700908
98Male pseudohermaphroditism (HP:0000037)2.09657840
99Exotropia (HP:0000577)2.07703871
100Anxiety (HP:0000739)2.07219900
101Supernumerary spleens (HP:0009799)2.06997305
102Termporal pattern (HP:0011008)2.06796983
103Insidious onset (HP:0003587)2.06796983
104Optic nerve hypoplasia (HP:0000609)2.05119826
105Abnormality of ocular smooth pursuit (HP:0000617)2.04999994
106Abnormal ciliary motility (HP:0012262)2.04741080
107Widely spaced teeth (HP:0000687)2.02973939
108Impaired vibratory sensation (HP:0002495)2.02638105
109Narrow forehead (HP:0000341)2.02182846
110Postaxial foot polydactyly (HP:0001830)2.01674537
111Depression (HP:0000716)1.99939158
112Decreased central vision (HP:0007663)1.95883252
113Tubulointerstitial abnormality (HP:0001969)1.95186236
114Gait ataxia (HP:0002066)1.95087412
115Dyskinesia (HP:0100660)1.94791270
116Hypoplasia of the fovea (HP:0007750)1.93753353
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.93753353
118Concave nail (HP:0001598)1.93604073
119Polyuria (HP:0000103)1.92603401
120Abnormal biliary tract physiology (HP:0012439)1.92557710
121Bile duct proliferation (HP:0001408)1.92557710
122Abnormality of binocular vision (HP:0011514)1.91968607
123Diplopia (HP:0000651)1.91968607
124Inappropriate behavior (HP:0000719)1.91268893
125Abnormality of macular pigmentation (HP:0008002)1.90888988
126Gastroesophageal reflux (HP:0002020)1.90612957
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90352831
128Esotropia (HP:0000565)1.89177655
129Specific learning disability (HP:0001328)1.89058263
130Poor coordination (HP:0002370)1.89035003
131Pheochromocytoma (HP:0002666)1.88871282
132Narrow nasal bridge (HP:0000446)1.87983436
133Optic disc pallor (HP:0000543)1.87723358
134Genital tract atresia (HP:0001827)1.87453295
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86926071
136Absent/shortened dynein arms (HP:0200106)1.86589763
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.86589763
138Congenital hepatic fibrosis (HP:0002612)1.84163677
139Decreased circulating renin level (HP:0003351)1.82421734
140Vaginal atresia (HP:0000148)1.82200784
141Bradykinesia (HP:0002067)1.81898026
142Methylmalonic acidemia (HP:0002912)1.81420786
143Action tremor (HP:0002345)1.80448470
144Lipid accumulation in hepatocytes (HP:0006561)1.79986517
145Supranuclear gaze palsy (HP:0000605)1.79003470
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.78587799
147Abnormality of the corticospinal tract (HP:0002492)1.78209657
148Hypoventilation (HP:0002791)1.77055683
149Hepatic necrosis (HP:0002605)1.76502243
150Hepatocellular necrosis (HP:0001404)1.76405270
151Degeneration of the lateral corticospinal tracts (HP:0002314)1.76255954
152Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76255954
153Postural instability (HP:0002172)1.76195450
154Spastic gait (HP:0002064)1.75838473
155Incomplete penetrance (HP:0003829)1.75665617
156Hyperglycinemia (HP:0002154)1.75580867
157Abnormality of the fovea (HP:0000493)1.74501014
158Cerebellar dysplasia (HP:0007033)1.73826977
159Oligomenorrhea (HP:0000876)1.73615974
160Intellectual disability, severe (HP:0010864)1.72347876
161Urinary urgency (HP:0000012)1.70607882
162Neuroendocrine neoplasm (HP:0100634)1.70162054
163Mitochondrial inheritance (HP:0001427)1.69855320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.47623172
2EPHA44.43328082
3NTRK34.03120289
4FRK3.96635156
5MAP2K73.17652319
6MAP3K43.12992094
7MAP3K122.91190081
8DAPK22.87922134
9TLK12.67464009
10MAP4K22.50249345
11CCNB12.48090401
12PLK22.48004250
13AKT32.42328788
14DAPK12.35600994
15MAP3K92.21614330
16ADRBK22.20365037
17PINK12.19956284
18CDK192.19098594
19PRPF4B2.10879721
20TNIK1.98564964
21ZAK1.97691435
22MAP2K41.93623818
23MARK11.92162778
24RIPK41.88966045
25DYRK21.86965829
26MINK11.77208593
27BCKDK1.75144090
28GRK11.65100585
29SIK31.54912202
30MAPK131.53852329
31SIK21.38419293
32OXSR11.35283897
33NTRK21.33441899
34WNK41.30749534
35CAMKK21.28560337
36KSR11.28423249
37PNCK1.27359779
38PAK61.27106121
39GRK51.19291215
40NUAK11.19151408
41PRKCG1.17401679
42CSNK1G31.15470417
43CAMK2A1.14941795
44PASK1.14299017
45CSNK1A1L1.13282360
46SGK21.13124627
47NME11.10294601
48CDK51.09443950
49STK391.02973497
50CAMK2B1.02874746
51ERBB31.02093669
52FES1.01862275
53BMPR21.00613624
54TXK1.00562523
55CSNK1G11.00370305
56SGK4940.99162839
57SGK2230.99162839
58PTK2B0.99091594
59TRIM280.96600655
60TAOK30.94658771
61PRKD30.92522023
62EPHA30.90523578
63BRAF0.87044870
64FGFR20.81438184
65CAMKK10.78758088
66FGR0.78754795
67CDK30.78672841
68PRKCE0.76409288
69TSSK60.76116539
70ARAF0.75350512
71MAP3K130.73631520
72CDK180.70842757
73KSR20.69952583
74SGK10.69043325
75CAMK10.68079136
76SGK30.66850919
77MAP3K60.66555752
78CDK150.63868651
79TIE10.63853570
80CDK140.62529622
81PDK40.62351190
82PDK30.62351190
83DYRK30.62195511
84MAPK70.62075906
85RPS6KA50.61444919
86WNK30.60888514
87STK160.60593999
88ACVR1B0.60537983
89PKN10.59938915
90BCR0.59141183
91MAPK120.58471985
92DAPK30.58002988
93FER0.57925768
94NTRK10.54165851
95BRSK20.53824934
96CDK11A0.53334294
97CAMK2D0.53092055
98DYRK1A0.52725077
99MUSK0.49720301
100EIF2AK30.49702612
101MAP2K60.48915073
102BRD40.47567157
103NEK20.47333014
104STK380.47011343
105STK110.46611840
106UHMK10.46468198
107MAPKAPK50.45960871
108ADRBK10.45594171
109CAMK2G0.45254186
110CSNK1G20.43833710
111RAF10.41989565
112CSNK1D0.41781033
113PLK40.41748202
114MKNK20.41477124
115CAMK40.41418760
116VRK10.41030959
117CAMK1G0.40704085
118TGFBR10.39409575
119MYLK0.38677812
120CDK80.37389812
121PAK30.37118570
122ROCK20.37053533
123SRPK10.36487301
124PHKG10.35073627
125PHKG20.35073627
126MAPK150.35072952
127PRKAA10.34841724
128TNK20.34787086
129GRK70.34057433
130PDK10.33973751
131CSNK1A10.33738291
132PRKACA0.32920293
133INSRR0.32899853
134GRK60.32703642
135CAMK1D0.32340567
136MARK20.31338108
137PDPK10.29925395
138RPS6KA30.29821176
139PRKCZ0.29342202
140CSNK1E0.27767115
141MAP2K10.27686413
142PLK30.27636356
143PRKCB0.27469048
144BMPR1B0.27409044
145PIK3CA0.26664128
146PRKCA0.26595428
147PRKG10.25522213
148LATS20.25285239

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.70973985
2Synaptic vesicle cycle_Homo sapiens_hsa047213.89558567
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.19753493
4Collecting duct acid secretion_Homo sapiens_hsa049662.99881169
5Circadian entrainment_Homo sapiens_hsa047132.80178713
6Long-term potentiation_Homo sapiens_hsa047202.79975319
7Morphine addiction_Homo sapiens_hsa050322.63872036
8GABAergic synapse_Homo sapiens_hsa047272.63816235
9Glutamatergic synapse_Homo sapiens_hsa047242.63521258
10Amphetamine addiction_Homo sapiens_hsa050312.60236266
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58344939
12Olfactory transduction_Homo sapiens_hsa047402.31641428
13Dopaminergic synapse_Homo sapiens_hsa047282.09074941
14Salivary secretion_Homo sapiens_hsa049702.06907859
15Taste transduction_Homo sapiens_hsa047422.05819275
16Protein export_Homo sapiens_hsa030602.00100737
17Linoleic acid metabolism_Homo sapiens_hsa005911.96382794
18Insulin secretion_Homo sapiens_hsa049111.92334263
19Serotonergic synapse_Homo sapiens_hsa047261.87708337
20Butanoate metabolism_Homo sapiens_hsa006501.87088942
21Long-term depression_Homo sapiens_hsa047301.86482529
22Renin secretion_Homo sapiens_hsa049241.83100290
23Vibrio cholerae infection_Homo sapiens_hsa051101.74413369
24Calcium signaling pathway_Homo sapiens_hsa040201.72494104
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.71075085
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65534874
27Oxytocin signaling pathway_Homo sapiens_hsa049211.65111559
28Cholinergic synapse_Homo sapiens_hsa047251.61709374
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60171234
30Oxidative phosphorylation_Homo sapiens_hsa001901.59980087
31Gastric acid secretion_Homo sapiens_hsa049711.53466718
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53283844
33Basal transcription factors_Homo sapiens_hsa030221.52264760
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44998016
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44599218
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43702827
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38236697
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36599759
39Cocaine addiction_Homo sapiens_hsa050301.35901237
40Nitrogen metabolism_Homo sapiens_hsa009101.35695029
41Phototransduction_Homo sapiens_hsa047441.35088423
42Ether lipid metabolism_Homo sapiens_hsa005651.31730086
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30035707
44Tryptophan metabolism_Homo sapiens_hsa003801.29714882
45Cardiac muscle contraction_Homo sapiens_hsa042601.21614835
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17956388
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17899391
48GnRH signaling pathway_Homo sapiens_hsa049121.16232062
49Caffeine metabolism_Homo sapiens_hsa002321.16130752
50Alzheimers disease_Homo sapiens_hsa050101.16060988
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14800001
52cAMP signaling pathway_Homo sapiens_hsa040241.14301767
53Axon guidance_Homo sapiens_hsa043601.14139327
54Propanoate metabolism_Homo sapiens_hsa006401.14025693
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.12593011
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.11857504
57Selenocompound metabolism_Homo sapiens_hsa004501.11624546
58Gap junction_Homo sapiens_hsa045401.10293877
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07390021
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04559050
61RNA polymerase_Homo sapiens_hsa030201.04489037
62RNA degradation_Homo sapiens_hsa030181.00020535
63Circadian rhythm_Homo sapiens_hsa047100.99642546
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99223736
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95894376
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95263459
67Fanconi anemia pathway_Homo sapiens_hsa034600.94926446
68Retinol metabolism_Homo sapiens_hsa008300.93842777
69ErbB signaling pathway_Homo sapiens_hsa040120.90289749
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.89362933
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88245353
72Rheumatoid arthritis_Homo sapiens_hsa053230.88026920
73Steroid biosynthesis_Homo sapiens_hsa001000.85751231
74Chemical carcinogenesis_Homo sapiens_hsa052040.85614118
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85223892
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85014730
77Estrogen signaling pathway_Homo sapiens_hsa049150.83766069
78Type II diabetes mellitus_Homo sapiens_hsa049300.83420794
79Parkinsons disease_Homo sapiens_hsa050120.83353935
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83031007
81Melanogenesis_Homo sapiens_hsa049160.81529130
82Glioma_Homo sapiens_hsa052140.76544132
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75761130
84Dilated cardiomyopathy_Homo sapiens_hsa054140.72463901
85Hedgehog signaling pathway_Homo sapiens_hsa043400.71708147
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70379029
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70105075
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69753113
89MAPK signaling pathway_Homo sapiens_hsa040100.69628355
90Peroxisome_Homo sapiens_hsa041460.68891539
91Pancreatic secretion_Homo sapiens_hsa049720.67803898
92Huntingtons disease_Homo sapiens_hsa050160.66773632
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65735599
94Sulfur relay system_Homo sapiens_hsa041220.62319483
95ABC transporters_Homo sapiens_hsa020100.61883391
96Arachidonic acid metabolism_Homo sapiens_hsa005900.59284152
97Oocyte meiosis_Homo sapiens_hsa041140.58331386
98Metabolic pathways_Homo sapiens_hsa011000.58054164
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57780849
100Phagosome_Homo sapiens_hsa041450.57501400
101beta-Alanine metabolism_Homo sapiens_hsa004100.57151718
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.55092045
103Homologous recombination_Homo sapiens_hsa034400.54717418
104Ras signaling pathway_Homo sapiens_hsa040140.54621679
105Glucagon signaling pathway_Homo sapiens_hsa049220.53934238
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49428769
107Choline metabolism in cancer_Homo sapiens_hsa052310.49366299
108Purine metabolism_Homo sapiens_hsa002300.47093168
109Vitamin digestion and absorption_Homo sapiens_hsa049770.46941287
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46485516
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43532935
112Sulfur metabolism_Homo sapiens_hsa009200.43257288
113Glycerolipid metabolism_Homo sapiens_hsa005610.42763899
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42651822
115African trypanosomiasis_Homo sapiens_hsa051430.41820109
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40839093
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40340743
118Tyrosine metabolism_Homo sapiens_hsa003500.39754597
119Pyruvate metabolism_Homo sapiens_hsa006200.39635016
120Inositol phosphate metabolism_Homo sapiens_hsa005620.39484516
121Wnt signaling pathway_Homo sapiens_hsa043100.39185346
122Thyroid hormone synthesis_Homo sapiens_hsa049180.39146013
123Rap1 signaling pathway_Homo sapiens_hsa040150.39009764
124Dorso-ventral axis formation_Homo sapiens_hsa043200.38831639
125Type I diabetes mellitus_Homo sapiens_hsa049400.37905914
126Fat digestion and absorption_Homo sapiens_hsa049750.37614098
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37414461
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35986076
129Arginine and proline metabolism_Homo sapiens_hsa003300.35275895
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33984336
131Alcoholism_Homo sapiens_hsa050340.32483217
132Ovarian steroidogenesis_Homo sapiens_hsa049130.32467964
133One carbon pool by folate_Homo sapiens_hsa006700.31555970
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28348632
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27854628
136Melanoma_Homo sapiens_hsa052180.26875113
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26558755
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24859941
139VEGF signaling pathway_Homo sapiens_hsa043700.22951271
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20709559
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.20611058
142Renal cell carcinoma_Homo sapiens_hsa052110.19423124
143Prion diseases_Homo sapiens_hsa050200.16488111
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15481804
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15031811
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.14899374
147Insulin signaling pathway_Homo sapiens_hsa049100.14832643
148Regulation of autophagy_Homo sapiens_hsa041400.14395618

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