ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	head development (GO:0060322)	4.40690414
2	seminiferous tubule development (GO:0072520)	4.36423730
3	positive regulation of gastrulation (GO:2000543)	4.18420732
4	response to pheromone (GO:0019236)	4.16237942
5	DNA double-strand break processing (GO:0000729)	4.15856810
6	indolalkylamine metabolic process (GO:0006586)	3.75581320
7	retinal ganglion cell axon guidance (GO:0031290)	3.72629927
8	resolution of meiotic recombination intermediates (GO:0000712)	3.67497782
9	pyrimidine nucleobase catabolic process (GO:0006208)	3.66243855
10	dendritic spine morphogenesis (GO:0060997)	3.57480129
11	protein polyglutamylation (GO:0018095)	3.50064151
12	respiratory chain complex IV assembly (GO:0008535)	3.49651863
13	replication fork processing (GO:0031297)	3.37094025
14	synaptic vesicle maturation (GO:0016188)	3.36109350
15	olfactory bulb development (GO:0021772)	3.31903613
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22351833
17	presynaptic membrane assembly (GO:0097105)	3.22221212
18	somite rostral/caudal axis specification (GO:0032525)	3.21518554
19	cytochrome complex assembly (GO:0017004)	3.20925855
20	forebrain neuron differentiation (GO:0021879)	3.16099700
21	hindbrain development (GO:0030902)	3.15558374
22	nonmotile primary cilium assembly (GO:0035058)	3.14521174
23	nucleobase catabolic process (GO:0046113)	3.14089343
24	inositol phosphate catabolic process (GO:0071545)	3.11031151
25	dentate gyrus development (GO:0021542)	3.10056558
26	glycosphingolipid biosynthetic process (GO:0006688)	3.08614536
27	behavioral response to nicotine (GO:0035095)	3.04954098
28	cilium movement (GO:0003341)	3.03045103
29	protein complex biogenesis (GO:0070271)	3.02838607
30	intraciliary transport (GO:0042073)	2.93707050
31	acrosome reaction (GO:0007340)	2.92828202
32	negative regulation of neurotransmitter transport (GO:0051589)	2.90247286
33	presynaptic membrane organization (GO:0097090)	2.87548663
34	epithelial cilium movement (GO:0003351)	2.87060971
35	NADH dehydrogenase complex assembly (GO:0010257)	2.84977883
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.84977883
37	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.84977883
38	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.84292916
39	axoneme assembly (GO:0035082)	2.83497389
40	retinal cone cell development (GO:0046549)	2.81237883
41	synapsis (GO:0007129)	2.79806671
42	regulation of hexokinase activity (GO:1903299)	2.78548063
43	regulation of glucokinase activity (GO:0033131)	2.78548063
44	neural tube formation (GO:0001841)	2.76864510
45	positive regulation of histone H3-K4 methylation (GO:0051571)	2.76783015
46	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.74933862
47	intestinal cholesterol absorption (GO:0030299)	2.73396388
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.72876735
49	histone H2A acetylation (GO:0043968)	2.70558136
50	forebrain morphogenesis (GO:0048853)	2.70246156
51	cilium organization (GO:0044782)	2.67460272
52	cilium assembly (GO:0042384)	2.67071432
53	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.66039556
54	inositol phosphate dephosphorylation (GO:0046855)	2.66039556
55	retina layer formation (GO:0010842)	2.65925584
56	male meiosis I (GO:0007141)	2.64672820
57	central nervous system projection neuron axonogenesis (GO:0021952)	2.64141140
58	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.63934968
59	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.63934968
60	negative regulation of neurotransmitter secretion (GO:0046929)	2.63479317
61	DNA integration (GO:0015074)	2.61908864
62	spinal cord association neuron differentiation (GO:0021527)	2.61732948
63	microtubule anchoring (GO:0034453)	2.55826643
64	photoreceptor cell maintenance (GO:0045494)	2.54997230
65	water-soluble vitamin biosynthetic process (GO:0042364)	2.53996003
66	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.52625088
67	axonemal dynein complex assembly (GO:0070286)	2.51234179
68	ectoderm development (GO:0007398)	2.49717064
69	indole-containing compound metabolic process (GO:0042430)	2.47117281
70	auditory receptor cell differentiation (GO:0042491)	2.46898629
71	negative regulation of dendrite development (GO:2000171)	2.46542869
72	DNA deamination (GO:0045006)	2.46387948
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.45645139
74	prostate gland growth (GO:0060736)	2.45643316
75	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.44254832
76	central nervous system neuron axonogenesis (GO:0021955)	2.43032622
77	cerebellar Purkinje cell differentiation (GO:0021702)	2.42798280
78	neurotransmitter-gated ion channel clustering (GO:0072578)	2.42671860
79	behavioral response to ethanol (GO:0048149)	2.41810397
80	aggressive behavior (GO:0002118)	2.40639843
81	tryptophan metabolic process (GO:0006568)	2.39832124
82	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.39603440
83	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.39086062
84	phenol-containing compound catabolic process (GO:0019336)	2.38307952
85	heme transport (GO:0015886)	2.37977742
86	somite development (GO:0061053)	2.37172159
87	monoubiquitinated protein deubiquitination (GO:0035520)	2.36930215
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.36700973
89	indole-containing compound catabolic process (GO:0042436)	2.36586732
90	indolalkylamine catabolic process (GO:0046218)	2.36586732
91	tryptophan catabolic process (GO:0006569)	2.36586732
92	S-adenosylmethionine metabolic process (GO:0046500)	2.36336125
93	detection of light stimulus involved in sensory perception (GO:0050962)	2.36222510
94	detection of light stimulus involved in visual perception (GO:0050908)	2.36222510
95	estrogen biosynthetic process (GO:0006703)	2.36109406
96	iron coordination entity transport (GO:1901678)	2.33103784
97	regulation of Rac protein signal transduction (GO:0035020)	2.32063308
98	cilium morphogenesis (GO:0060271)	2.31269523
99	negative regulation of digestive system process (GO:0060457)	2.31246879
100	regulation of meiosis I (GO:0060631)	2.29469948

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.85775563
2	FUS_26573619_Chip-Seq_HEK293_Human	3.11819737
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.01651721
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94591231
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.87621375
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.84571659
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.78408807
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.69061225
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.64050348
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61376404
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46698053
12	VDR_22108803_ChIP-Seq_LS180_Human	2.43552026
13	EWS_26573619_Chip-Seq_HEK293_Human	2.27161218
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.10389473
15	P300_19829295_ChIP-Seq_ESCs_Human	2.05372502
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00174900
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.96095104
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92970336
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86735110
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85312217
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85312217
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.83848128
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82109806
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79663879
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.75876493
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74652983
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.73398871
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67539516
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.66157741
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.63558619
31	STAT3_23295773_ChIP-Seq_U87_Human	1.62047880
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61259568
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.61259568
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.61037118
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.60447484
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60385617
37	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.49309227
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.48956097
39	TCF4_23295773_ChIP-Seq_U87_Human	1.48241090
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48055234
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46437792
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45434386
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45025654
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44171290
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43908239
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43199038
47	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.41961290
48	AR_25329375_ChIP-Seq_VCAP_Human	1.40811888
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.40561101
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40010315
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39284778
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37236141
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35502566
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34531171
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34448499
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33191640
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31608808
58	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30318400
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.30120006
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29079214
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28574528
62	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.28218719
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27401598
64	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.26385409
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25467998
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24294259
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.23840177
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23723119
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23097261
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23097261
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22255495
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20074413
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18201740
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17700948
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16508986
76	P300_18555785_Chip-Seq_ESCs_Mouse	1.16387101
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16087517
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.15635913
79	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13058925
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11993212
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11486553
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10796250
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10667863
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10364598
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.10215003
86	TP53_16413492_ChIP-PET_HCT116_Human	1.07580440
87	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.06287889
88	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06234720
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04380550
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04256030
91	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.02605426
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01075110
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01075110
94	TBL1_22424771_ChIP-Seq_293T_Human	1.00446503
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00429035
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00005711
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99807205
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98758194
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98531500
100	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98316905

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.10446801
2	MP0002102_abnormal_ear_morphology	3.69225379
3	MP0003121_genomic_imprinting	3.27780517
4	MP0003122_maternal_imprinting	2.87547788
5	MP0008877_abnormal_DNA_methylation	2.60729822
6	MP0003880_abnormal_central_pattern	2.41683500
7	MP0006292_abnormal_olfactory_placode	2.39740538
8	MP0005645_abnormal_hypothalamus_physiol	2.21758203
9	MP0001529_abnormal_vocalization	2.09266962
10	MP0006276_abnormal_autonomic_nervous	2.00723207
11	MP0000778_abnormal_nervous_system	1.99764153
12	MP0003890_abnormal_embryonic-extraembry	1.98193660
13	MP0005551_abnormal_eye_electrophysiolog	1.95271427
14	MP0000372_irregular_coat_pigmentation	1.90951393
15	MP0002638_abnormal_pupillary_reflex	1.90122040
16	MP0006072_abnormal_retinal_apoptosis	1.85232973
17	MP0005084_abnormal_gallbladder_morpholo	1.85101207
18	MP0004133_heterotaxia	1.76351170
19	MP0005253_abnormal_eye_physiology	1.73681601
20	MP0009046_muscle_twitch	1.73043132
21	MP0005646_abnormal_pituitary_gland	1.67880360
22	MP0004859_abnormal_synaptic_plasticity	1.60000293
23	MP0002837_dystrophic_cardiac_calcinosis	1.57730152
24	MP0002160_abnormal_reproductive_system	1.57668970
25	MP0002822_catalepsy	1.53101271
26	MP0005386_behavior/neurological_phenoty	1.52195209
27	MP0004924_abnormal_behavior	1.52195209
28	MP0000631_abnormal_neuroendocrine_gland	1.50802127
29	MP0009697_abnormal_copulation	1.49138113
30	MP0002234_abnormal_pharynx_morphology	1.47046429
31	MP0008057_abnormal_DNA_replication	1.45538203
32	MP0003252_abnormal_bile_duct	1.45099277
33	MP0002272_abnormal_nervous_system	1.40915683
34	MP0001486_abnormal_startle_reflex	1.38618165
35	MP0008872_abnormal_physiological_respon	1.37969006
36	MP0000955_abnormal_spinal_cord	1.36358942
37	MP0001968_abnormal_touch/_nociception	1.35187719
38	MP0009745_abnormal_behavioral_response	1.32938469
39	MP0003123_paternal_imprinting	1.31386673
40	MP0000516_abnormal_urinary_system	1.28581798
41	MP0005367_renal/urinary_system_phenotyp	1.28581798
42	MP0002938_white_spotting	1.28567595
43	MP0002184_abnormal_innervation	1.28494561
44	MP0000569_abnormal_digit_pigmentation	1.28012972
45	MP0002751_abnormal_autonomic_nervous	1.27720719
46	MP0000427_abnormal_hair_cycle	1.25296159
47	MP0005075_abnormal_melanosome_morpholog	1.24314161
48	MP0003656_abnormal_erythrocyte_physiolo	1.23308697
49	MP0008789_abnormal_olfactory_epithelium	1.22446773
50	MP0003635_abnormal_synaptic_transmissio	1.22104476
51	MP0008058_abnormal_DNA_repair	1.21952559
52	MP0002067_abnormal_sensory_capabilities	1.21309639
53	MP0002095_abnormal_skin_pigmentation	1.20383107
54	MP0002064_seizures	1.19602440
55	MP0004147_increased_porphyrin_level	1.18606554
56	MP0004142_abnormal_muscle_tone	1.16574426
57	MP0005389_reproductive_system_phenotype	1.16373648
58	MP0002752_abnormal_somatic_nervous	1.11088861
59	MP0002572_abnormal_emotion/affect_behav	1.10052286
60	MP0002557_abnormal_social/conspecific_i	1.09585413
61	MP0008995_early_reproductive_senescence	1.06772624
62	MP0001986_abnormal_taste_sensitivity	1.06500503
63	MP0005187_abnormal_penis_morphology	1.06201586
64	MP0001293_anophthalmia	1.05519405
65	MP0004270_analgesia	1.04691704
66	MP0004145_abnormal_muscle_electrophysio	1.04553861
67	MP0002736_abnormal_nociception_after	1.03701943
68	MP0002882_abnormal_neuron_morphology	1.02506832
69	MP0003195_calcinosis	1.01853983
70	MP0002063_abnormal_learning/memory/cond	1.01062074
71	MP0005195_abnormal_posterior_eye	1.00799102
72	MP0001984_abnormal_olfaction	0.99579613
73	MP0003567_abnormal_fetal_cardiomyocyte	0.97904824
74	MP0002229_neurodegeneration	0.97882991
75	MP0002928_abnormal_bile_duct	0.97828320
76	MP0002733_abnormal_thermal_nociception	0.97354489
77	MP0000049_abnormal_middle_ear	0.95927755
78	MP0000383_abnormal_hair_follicle	0.94022031
79	MP0005394_taste/olfaction_phenotype	0.92555495
80	MP0005499_abnormal_olfactory_system	0.92555495
81	MP0002876_abnormal_thyroid_physiology	0.88736882
82	MP0001485_abnormal_pinna_reflex	0.88317377
83	MP0005391_vision/eye_phenotype	0.86545837
84	MP0001919_abnormal_reproductive_system	0.86377454
85	MP0002653_abnormal_ependyma_morphology	0.86083733
86	MP0002127_abnormal_cardiovascular_syste	0.84453953
87	MP0001970_abnormal_pain_threshold	0.83722352
88	MP0004811_abnormal_neuron_physiology	0.83595662
89	MP0003698_abnormal_male_reproductive	0.83047725
90	MP0005423_abnormal_somatic_nervous	0.83015277
91	MP0001764_abnormal_homeostasis	0.82799291
92	MP0001188_hyperpigmentation	0.82031918
93	MP0002152_abnormal_brain_morphology	0.81811344
94	MP0001501_abnormal_sleep_pattern	0.80152994
95	MP0003633_abnormal_nervous_system	0.80090067
96	MP0003283_abnormal_digestive_organ	0.79845715
97	MP0002909_abnormal_adrenal_gland	0.78242408
98	MP0002734_abnormal_mechanical_nocicepti	0.78055217
99	MP0003943_abnormal_hepatobiliary_system	0.77107123
100	MP0000013_abnormal_adipose_tissue	0.76220712

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.83944287
2	Abnormality of alanine metabolism (HP:0010916)	3.83944287
3	Hyperalaninemia (HP:0003348)	3.83944287
4	Abnormality of midbrain morphology (HP:0002418)	3.53387895
5	Molar tooth sign on MRI (HP:0002419)	3.53387895
6	Chronic hepatic failure (HP:0100626)	3.44922043
7	Panhypogammaglobulinemia (HP:0003139)	3.33521212
8	Volvulus (HP:0002580)	3.30949725
9	Pancreatic fibrosis (HP:0100732)	3.30886550
10	True hermaphroditism (HP:0010459)	3.07347360
11	Intestinal atresia (HP:0011100)	3.00851411
12	Nephronophthisis (HP:0000090)	2.97240453
13	Abnormality of the labia minora (HP:0012880)	2.94260009
14	Pancreatic cysts (HP:0001737)	2.88779048
15	Absent speech (HP:0001344)	2.85085926
16	Drooling (HP:0002307)	2.78554374
17	Thyroiditis (HP:0100646)	2.74770432
18	Abnormality of the renal medulla (HP:0100957)	2.66553072
19	Abnormal ciliary motility (HP:0012262)	2.66189167
20	Colon cancer (HP:0003003)	2.59735898
21	Excessive salivation (HP:0003781)	2.55431478
22	Methylmalonic acidemia (HP:0002912)	2.49655733
23	Cerebellar dysplasia (HP:0007033)	2.49143556
24	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.46394754
25	Short 1st metacarpal (HP:0010034)	2.46394754
26	Congenital stationary night blindness (HP:0007642)	2.45931421
27	Medial flaring of the eyebrow (HP:0010747)	2.43254749
28	Hypoplasia of the thymus (HP:0000778)	2.40236273
29	Hyperventilation (HP:0002883)	2.38957327
30	Type II lissencephaly (HP:0007260)	2.36564954
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.35618159
32	B lymphocytopenia (HP:0010976)	2.35523818
33	Febrile seizures (HP:0002373)	2.32395728
34	Narrow forehead (HP:0000341)	2.29607771
35	Retinal dysplasia (HP:0007973)	2.28365209
36	Abnormality of macular pigmentation (HP:0008002)	2.26845891
37	Dyskinesia (HP:0100660)	2.25004167
38	Atonic seizures (HP:0010819)	2.24375008
39	Abolished electroretinogram (ERG) (HP:0000550)	2.18762226
40	Severe combined immunodeficiency (HP:0004430)	2.16259080
41	Cystic liver disease (HP:0006706)	2.15328004
42	3-Methylglutaconic aciduria (HP:0003535)	2.12089458
43	Gait imbalance (HP:0002141)	2.11593484
44	Abnormality of the 1st metacarpal (HP:0010009)	2.11366634
45	Attenuation of retinal blood vessels (HP:0007843)	2.11348448
46	Abnormality of B cell number (HP:0010975)	2.10924590
47	Congenital primary aphakia (HP:0007707)	2.09270225
48	Occipital encephalocele (HP:0002085)	2.09091520
49	Abnormal hair whorl (HP:0010721)	2.07831494
50	Tubulointerstitial nephritis (HP:0001970)	2.04867243
51	Widely spaced teeth (HP:0000687)	2.04704574
52	Hyperglycinemia (HP:0002154)	2.03418515
53	Thyroid-stimulating hormone excess (HP:0002925)	2.02231414
54	Hemiparesis (HP:0001269)	2.01803599
55	Aqueductal stenosis (HP:0002410)	2.00840758
56	Abnormality of the renal cortex (HP:0011035)	2.00170132
57	Nephrogenic diabetes insipidus (HP:0009806)	1.97816468
58	Hypothermia (HP:0002045)	1.96525100
59	Oligodactyly (hands) (HP:0001180)	1.96063774
60	Pachygyria (HP:0001302)	1.95453884
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93986348
62	Lissencephaly (HP:0001339)	1.93492795
63	Renal cortical cysts (HP:0000803)	1.91633069
64	Genital tract atresia (HP:0001827)	1.90530688
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.88657258
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87196786
67	Bile duct proliferation (HP:0001408)	1.84860548
68	Abnormal biliary tract physiology (HP:0012439)	1.84860548
69	Oculomotor apraxia (HP:0000657)	1.83702150
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83571072
71	Progressive cerebellar ataxia (HP:0002073)	1.82992235
72	Failure to thrive in infancy (HP:0001531)	1.82445984
73	Broad-based gait (HP:0002136)	1.82312115
74	Hypsarrhythmia (HP:0002521)	1.82084344
75	Protruding tongue (HP:0010808)	1.81972832
76	Specific learning disability (HP:0001328)	1.79944107
77	Dialeptic seizures (HP:0011146)	1.79421526
78	Hypomagnesemia (HP:0002917)	1.78684791
79	Progressive macrocephaly (HP:0004481)	1.77679818
80	EEG with generalized epileptiform discharges (HP:0011198)	1.77315194
81	Anencephaly (HP:0002323)	1.74984822
82	Acute necrotizing encephalopathy (HP:0006965)	1.74523601
83	Hepatocellular necrosis (HP:0001404)	1.74104230
84	Growth hormone deficiency (HP:0000824)	1.73779889
85	Tented upper lip vermilion (HP:0010804)	1.73734944
86	Metaphyseal dysplasia (HP:0100255)	1.73179996
87	Abnormality of serum amino acid levels (HP:0003112)	1.70925306
88	Congenital hepatic fibrosis (HP:0002612)	1.70900660
89	Agitation (HP:0000713)	1.70454047
90	Hypoplastic iliac wings (HP:0002866)	1.69811880
91	Absence seizures (HP:0002121)	1.68261787
92	Decreased central vision (HP:0007663)	1.68241556
93	Epileptiform EEG discharges (HP:0011182)	1.67889248
94	Hepatic necrosis (HP:0002605)	1.67559895
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67275870
96	Dyschromatopsia (HP:0007641)	1.67263502
97	Abnormality of the corticospinal tract (HP:0002492)	1.67071359
98	Postaxial hand polydactyly (HP:0001162)	1.66746849
99	Myokymia (HP:0002411)	1.66327653
100	Short foot (HP:0001773)	1.64572904

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.21690191
2	MAP4K2	3.44694315
3	MAP3K4	2.96892524
4	NUAK1	2.84189017
5	MAPK13	2.51660262
6	BMPR1B	2.30787412
7	MINK1	2.22308727
8	CASK	1.96436731
9	TAOK3	1.88781412
10	AKT3	1.84373711
11	CSNK1G3	1.74677976
12	CSNK1G2	1.72967112
13	GRK1	1.67931709
14	WNK3	1.67371260
15	EIF2AK3	1.64874798
16	TNIK	1.61345961
17	CSNK1A1L	1.53220523
18	MKNK2	1.52474254
19	MAP2K7	1.51088732
20	PRKD3	1.51082930
21	STK16	1.50792320
22	CSNK1G1	1.50317628
23	PINK1	1.49154222
24	TRIM28	1.47936161
25	CCNB1	1.47809717
26	ERBB3	1.40215489
27	PLK2	1.36956365
28	MARK1	1.35478197
29	MKNK1	1.35302938
30	DYRK2	1.35108745
31	ADRBK2	1.34890028
32	TAF1	1.32843350
33	OXSR1	1.26680916
34	PBK	1.25055508
35	EPHB1	1.21652381
36	STK39	1.15063630
37	INSRR	1.09744952
38	PAK3	1.04929546
39	MAPKAPK3	1.04663916
40	STK38L	1.04484221
41	PNCK	1.03156380
42	VRK1	0.96869316
43	VRK2	0.95803254
44	TNK2	0.92736311
45	BRSK2	0.91577546
46	PLK3	0.88656449
47	BRAF	0.87481341
48	SGK494	0.86685904
49	SGK223	0.86685904
50	ACVR1B	0.84837432
51	FLT3	0.82092004
52	PRKCG	0.81506640
53	BCR	0.81016068
54	SGK2	0.80787349
55	MAP2K4	0.78821409
56	PLK4	0.78767755
57	PRKCE	0.78545208
58	ATR	0.78518493
59	RPS6KA4	0.78291876
60	TEC	0.76570960
61	FGFR2	0.75584619
62	NTRK2	0.70567642
63	EPHA4	0.68571618
64	CDK3	0.65184992
65	WNK4	0.63851124
66	DYRK1A	0.63258229
67	DYRK1B	0.60141495
68	ATM	0.56805349
69	MAP2K6	0.55479364
70	NTRK3	0.54453840
71	MAP3K6	0.54047314
72	BRD4	0.53392241
73	UHMK1	0.52201882
74	MST4	0.52167134
75	TGFBR1	0.51618638
76	EIF2AK2	0.50939156
77	RPS6KB1	0.50528299
78	CSNK1D	0.50010757
79	WEE1	0.49739114
80	PKN1	0.48196426
81	ZAK	0.47760235
82	DMPK	0.46958221
83	DYRK3	0.46145273
84	MAP2K2	0.44148359
85	CAMKK2	0.43424570
86	DAPK2	0.41660070
87	CSNK1E	0.39779822
88	PRKACA	0.39643980
89	IRAK2	0.38510958
90	EIF2AK1	0.37981972
91	PRKCH	0.37307092
92	CAMK2A	0.36012647
93	PRKCQ	0.35710953
94	PRKG1	0.35629613
95	CSNK1A1	0.35532546
96	CDK9	0.35307339
97	MAPKAPK5	0.33129341
98	NLK	0.33048413
99	SGK1	0.32871410
100	GRK5	0.32744443

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.14699564
2	Phototransduction_Homo sapiens_hsa04744	2.91987260
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.87433175
4	Butanoate metabolism_Homo sapiens_hsa00650	2.73700005
5	Protein export_Homo sapiens_hsa03060	2.40667214
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.39315838
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32628009
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29435775
9	Ether lipid metabolism_Homo sapiens_hsa00565	2.07879783
10	Nicotine addiction_Homo sapiens_hsa05033	2.04613549
11	RNA polymerase_Homo sapiens_hsa03020	2.03252353
12	Propanoate metabolism_Homo sapiens_hsa00640	1.95613849
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83002830
14	Long-term depression_Homo sapiens_hsa04730	1.82085218
15	Olfactory transduction_Homo sapiens_hsa04740	1.80285044
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78182793
17	Taste transduction_Homo sapiens_hsa04742	1.75690985
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75548242
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.72715704
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.65225218
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55461919
22	Basal transcription factors_Homo sapiens_hsa03022	1.49412114
23	Circadian entrainment_Homo sapiens_hsa04713	1.46823385
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.45799427
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44420951
26	ABC transporters_Homo sapiens_hsa02010	1.42742720
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39553054
28	GABAergic synapse_Homo sapiens_hsa04727	1.39162392
29	RNA degradation_Homo sapiens_hsa03018	1.38995448
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.37740659
31	Serotonergic synapse_Homo sapiens_hsa04726	1.34596105
32	Peroxisome_Homo sapiens_hsa04146	1.30467373
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.29008073
34	Circadian rhythm_Homo sapiens_hsa04710	1.24675388
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21337978
36	Morphine addiction_Homo sapiens_hsa05032	1.18504160
37	Insulin secretion_Homo sapiens_hsa04911	1.17569485
38	Homologous recombination_Homo sapiens_hsa03440	1.17528301
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.14305812
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.12089061
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.09427442
42	Regulation of autophagy_Homo sapiens_hsa04140	1.04460664
43	Salivary secretion_Homo sapiens_hsa04970	1.02732064
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.02554504
45	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01369269
46	Cocaine addiction_Homo sapiens_hsa05030	0.97875743
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.94506352
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.94182295
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92211521
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91899723
51	Purine metabolism_Homo sapiens_hsa00230	0.91051560
52	Renin secretion_Homo sapiens_hsa04924	0.88337788
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87939457
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.83497453
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77021783
56	Amphetamine addiction_Homo sapiens_hsa05031	0.76215221
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74948573
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73975990
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73178541
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72297444
61	Caffeine metabolism_Homo sapiens_hsa00232	0.70709117
62	Base excision repair_Homo sapiens_hsa03410	0.69779925
63	Retinol metabolism_Homo sapiens_hsa00830	0.66539177
64	Fatty acid elongation_Homo sapiens_hsa00062	0.66173241
65	Parkinsons disease_Homo sapiens_hsa05012	0.66166525
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.65987140
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63682905
68	Cholinergic synapse_Homo sapiens_hsa04725	0.62771715
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61422962
70	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61222553
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59450317
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59326547
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57223752
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55778710
75	Oocyte meiosis_Homo sapiens_hsa04114	0.54356433
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.53966747
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53893003
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.53342199
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53184368
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52615528
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.52186330
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51791183
83	Axon guidance_Homo sapiens_hsa04360	0.51220743
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48959657
85	Metabolic pathways_Homo sapiens_hsa01100	0.47587290
86	Lysine degradation_Homo sapiens_hsa00310	0.46890088
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45410365
88	Spliceosome_Homo sapiens_hsa03040	0.44313306
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42644603
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.42642773
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41009921
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40367054
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.40197181
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39783777
95	Long-term potentiation_Homo sapiens_hsa04720	0.39369881
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39332705
97	Gap junction_Homo sapiens_hsa04540	0.37264590
98	Huntingtons disease_Homo sapiens_hsa05016	0.37218253
99	Pancreatic secretion_Homo sapiens_hsa04972	0.37014798
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36492933

CDH12P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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