ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	kidney morphogenesis (GO:0060993)	6.30321853
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.80977376
3	ATP synthesis coupled proton transport (GO:0015986)	5.63191244
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.63191244
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.69066583
6	spinal cord association neuron differentiation (GO:0021527)	4.64330037
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.57391074
8	behavioral response to nicotine (GO:0035095)	4.54689162
9	sequestering of actin monomers (GO:0042989)	4.54620916
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.40429412
11	lens fiber cell development (GO:0070307)	4.36023330
12	metanephric nephron tubule development (GO:0072234)	4.34019131
13	metanephric tubule development (GO:0072170)	4.34019131
14	collecting duct development (GO:0072044)	4.32227770
15	respiratory electron transport chain (GO:0022904)	4.20205446
16	respiratory tube development (GO:0030323)	4.17891631
17	lung-associated mesenchyme development (GO:0060484)	4.14646900
18	transmission of nerve impulse (GO:0019226)	4.13519421
19	electron transport chain (GO:0022900)	4.10990336
20	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.08255592
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.03043159
22	cartilage morphogenesis (GO:0060536)	3.85384729
23	nucleobase catabolic process (GO:0046113)	3.84860125
24	lung epithelium development (GO:0060428)	3.77871527
25	neuron recognition (GO:0008038)	3.72581965
26	metanephric nephron epithelium development (GO:0072243)	3.70396340
27	dendritic spine morphogenesis (GO:0060997)	3.58318969
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49505493
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49505493
30	NADH dehydrogenase complex assembly (GO:0010257)	3.49505493
31	auditory receptor cell differentiation (GO:0042491)	3.47181634
32	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.46862129
33	protein neddylation (GO:0045116)	3.45091191
34	viral transcription (GO:0019083)	3.43034778
35	metanephric epithelium development (GO:0072207)	3.39328395
36	translational termination (GO:0006415)	3.32636816
37	axon extension (GO:0048675)	3.29332393
38	opioid receptor signaling pathway (GO:0038003)	3.23884523
39	retinal ganglion cell axon guidance (GO:0031290)	3.22227022
40	hydrogen ion transmembrane transport (GO:1902600)	3.21908235
41	protein complex biogenesis (GO:0070271)	3.20114113
42	ATP biosynthetic process (GO:0006754)	3.19876362
43	nonmotile primary cilium assembly (GO:0035058)	3.13791093
44	pituitary gland development (GO:0021983)	3.06161794
45	protein localization to cilium (GO:0061512)	3.03761747
46	cell proliferation in forebrain (GO:0021846)	3.00128604
47	central nervous system myelination (GO:0022010)	2.98746203
48	axon ensheathment in central nervous system (GO:0032291)	2.98746203
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.96494974
50	intraciliary transport (GO:0042073)	2.96456350
51	postsynaptic membrane organization (GO:0001941)	2.94959665
52	water-soluble vitamin biosynthetic process (GO:0042364)	2.94948013
53	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.92149649
54	anatomical structure regression (GO:0060033)	2.91141758
55	protein targeting to ER (GO:0045047)	2.90570750
56	axonal fasciculation (GO:0007413)	2.88788454
57	cotranslational protein targeting to membrane (GO:0006613)	2.88286626
58	cell differentiation in spinal cord (GO:0021515)	2.85432583
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.83877554
60	membrane hyperpolarization (GO:0060081)	2.83841114
61	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.83475443
62	forebrain neuron differentiation (GO:0021879)	2.79847753
63	proton transport (GO:0015992)	2.78695133
64	dentate gyrus development (GO:0021542)	2.76923064
65	lung morphogenesis (GO:0060425)	2.76652154
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.76456217
67	hydrogen transport (GO:0006818)	2.76178301
68	limb development (GO:0060173)	2.76061884
69	appendage development (GO:0048736)	2.76061884
70	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75234742
71	nephron tubule development (GO:0072080)	2.74619545
72	chaperone-mediated protein transport (GO:0072321)	2.74009650
73	protein localization to endoplasmic reticulum (GO:0070972)	2.73402285
74	C4-dicarboxylate transport (GO:0015740)	2.72699232
75	kynurenine metabolic process (GO:0070189)	2.72549576
76	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.71445959
77	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.71337085
78	positive regulation of synapse assembly (GO:0051965)	2.71287389
79	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.68297059
80	negative regulation of membrane potential (GO:0045837)	2.65942785
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65329561
82	body morphogenesis (GO:0010171)	2.64593817
83	glycerophospholipid catabolic process (GO:0046475)	2.63695027
84	neuronal action potential propagation (GO:0019227)	2.63578712
85	motor neuron axon guidance (GO:0008045)	2.62204739
86	translational elongation (GO:0006414)	2.61818052
87	ribosomal small subunit biogenesis (GO:0042274)	2.61176602
88	neuronal action potential (GO:0019228)	2.59802257
89	short-term memory (GO:0007614)	2.59535788
90	respiratory chain complex IV assembly (GO:0008535)	2.58653222
91	neuron cell-cell adhesion (GO:0007158)	2.58563121
92	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.56767801
93	Sertoli cell development (GO:0060009)	2.54753763
94	response to dietary excess (GO:0002021)	2.51735633
95	presynaptic membrane assembly (GO:0097105)	2.51431156
96	tryptophan catabolic process (GO:0006569)	2.50190318
97	indole-containing compound catabolic process (GO:0042436)	2.50190318
98	indolalkylamine catabolic process (GO:0046218)	2.50190318
99	dopamine transport (GO:0015872)	2.49211866
100	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.48960347

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.36454064
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.07903297
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.99345471
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.89524650
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.21294905
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.19159448
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.04364479
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.02991512
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.38060502
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.36861098
11	REST_21632747_ChIP-Seq_MESCs_Mouse	2.33481626
12	VDR_22108803_ChIP-Seq_LS180_Human	2.28375593
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.25583847
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25440558
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.20249741
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.15965335
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12963771
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.10950253
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04252369
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95633782
21	FUS_26573619_Chip-Seq_HEK293_Human	1.85734592
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78944140
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.78541377
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.75325500
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73951818
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.73340247
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69676105
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.69019353
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.65728152
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.62723078
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.62723078
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.62236939
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.61128736
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59908825
35	P300_19829295_ChIP-Seq_ESCs_Human	1.58860352
36	EWS_26573619_Chip-Seq_HEK293_Human	1.56713638
37	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.56190615
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.54706907
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51904804
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51904804
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50887377
42	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.50162071
43	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.49713172
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48757441
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48599269
46	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.46284775
47	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.45713373
48	DROSHA_22980978_ChIP-Seq_HELA_Human	1.38088579
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37354764
50	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.35504800
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34459845
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30813948
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29685432
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.28430013
55	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26158309
56	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25595654
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23702215
58	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.23670995
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.21222169
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.20180837
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18101321
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17460669
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15009731
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14037110
65	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.13801089
66	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10951307
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.05920975
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05920975
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05000140
70	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04409934
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03603488
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02402045
73	AR_25329375_ChIP-Seq_VCAP_Human	1.01378219
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01344317
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.00073221
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99258321
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.98248582
78	TP53_22573176_ChIP-Seq_HFKS_Human	0.96827671
79	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.96363092
80	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.96235834
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95302290
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94744041
83	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.94674774
84	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93875166
85	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.92973524
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92542563
87	SMAD4_21799915_ChIP-Seq_A2780_Human	0.92493396
88	NCOR_22424771_ChIP-Seq_293T_Human	0.92149673
89	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.91697553
90	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91467990
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90558866
92	JUN_21703547_ChIP-Seq_K562_Human	0.89446226
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.88617790
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.87045211
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86527685
96	TCF4_23295773_ChIP-Seq_U87_Human	0.85870043
97	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.85206597
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85090502
99	SOX9_26525672_Chip-Seq_HEART_Mouse	0.85072438
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.84595345

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	5.05091381
2	MP0003122_maternal_imprinting	3.77419398
3	MP0009379_abnormal_foot_pigmentation	3.53779638
4	MP0003121_genomic_imprinting	2.92390768
5	MP0000566_synostosis	2.86987750
6	MP0003123_paternal_imprinting	2.74251537
7	MP0008877_abnormal_DNA_methylation	2.68689272
8	MP0006292_abnormal_olfactory_placode	2.61695722
9	MP0005646_abnormal_pituitary_gland	2.61662666
10	MP0002837_dystrophic_cardiac_calcinosis	2.27295115
11	MP0000778_abnormal_nervous_system	2.25207580
12	MP0010030_abnormal_orbit_morphology	2.21096162
13	MP0001346_abnormal_lacrimal_gland	1.96127656
14	MP0006276_abnormal_autonomic_nervous	1.93569829
15	MP0004885_abnormal_endolymph	1.91151423
16	MP0004742_abnormal_vestibular_system	1.87293343
17	MP0002938_white_spotting	1.86409480
18	MP0002653_abnormal_ependyma_morphology	1.81581570
19	MP0000631_abnormal_neuroendocrine_gland	1.69741282
20	MP0001485_abnormal_pinna_reflex	1.69524512
21	MP0001986_abnormal_taste_sensitivity	1.67576818
22	MP0004142_abnormal_muscle_tone	1.66495693
23	MP0000372_irregular_coat_pigmentation	1.62973583
24	MP0005248_abnormal_Harderian_gland	1.61887497
25	MP0005551_abnormal_eye_electrophysiolog	1.61545813
26	MP0004145_abnormal_muscle_electrophysio	1.59990906
27	MP0001968_abnormal_touch/_nociception	1.59420820
28	MP0002272_abnormal_nervous_system	1.56697222
29	MP0001529_abnormal_vocalization	1.55979995
30	MP0008789_abnormal_olfactory_epithelium	1.55379651
31	MP0004859_abnormal_synaptic_plasticity	1.55343808
32	MP0009745_abnormal_behavioral_response	1.51786602
33	MP0008875_abnormal_xenobiotic_pharmacok	1.51581355
34	MP0002734_abnormal_mechanical_nocicepti	1.47873593
35	MP0006072_abnormal_retinal_apoptosis	1.47496340
36	MP0002736_abnormal_nociception_after	1.46751118
37	MP0005394_taste/olfaction_phenotype	1.46329963
38	MP0005499_abnormal_olfactory_system	1.46329963
39	MP0000955_abnormal_spinal_cord	1.46007785
40	MP0008872_abnormal_physiological_respon	1.43252409
41	MP0002928_abnormal_bile_duct	1.39982703
42	MP0002064_seizures	1.36582011
43	MP0003880_abnormal_central_pattern	1.34981322
44	MP0005084_abnormal_gallbladder_morpholo	1.34928683
45	MP0002557_abnormal_social/conspecific_i	1.34558295
46	MP0005195_abnormal_posterior_eye	1.33312333
47	MP0001486_abnormal_startle_reflex	1.32642436
48	MP0003635_abnormal_synaptic_transmissio	1.32298702
49	MP0003938_abnormal_ear_development	1.30480569
50	MP0004133_heterotaxia	1.28771517
51	MP0002067_abnormal_sensory_capabilities	1.28138670
52	MP0009384_cardiac_valve_regurgitation	1.26796617
53	MP0001440_abnormal_grooming_behavior	1.25775309
54	MP0002735_abnormal_chemical_nociception	1.24104230
55	MP0002063_abnormal_learning/memory/cond	1.22800125
56	MP0002572_abnormal_emotion/affect_behav	1.22400860
57	MP0003283_abnormal_digestive_organ	1.22029252
58	MP0001293_anophthalmia	1.20767138
59	MP0002163_abnormal_gland_morphology	1.19825987
60	MP0002102_abnormal_ear_morphology	1.19137626
61	MP0002733_abnormal_thermal_nociception	1.17168784
62	MP0005379_endocrine/exocrine_gland_phen	1.16322047
63	MP0009046_muscle_twitch	1.16256624
64	MP0001970_abnormal_pain_threshold	1.15852720
65	MP0001984_abnormal_olfaction	1.13901690
66	MP0001905_abnormal_dopamine_level	1.13408352
67	MP0002752_abnormal_somatic_nervous	1.09645524
68	MP0000026_abnormal_inner_ear	1.07329225
69	MP0003252_abnormal_bile_duct	1.04158196
70	MP0000049_abnormal_middle_ear	0.99917698
71	MP0002876_abnormal_thyroid_physiology	0.99366178
72	MP0001963_abnormal_hearing_physiology	0.97698643
73	MP0003011_delayed_dark_adaptation	0.95272658
74	MP0002882_abnormal_neuron_morphology	0.93303615
75	MP0004270_analgesia	0.90601119
76	MP0005377_hearing/vestibular/ear_phenot	0.89083853
77	MP0003878_abnormal_ear_physiology	0.89083853
78	MP0002152_abnormal_brain_morphology	0.87735164
79	MP0003942_abnormal_urinary_system	0.85202104
80	MP0001324_abnormal_eye_pigmentation	0.83395337
81	MP0002184_abnormal_innervation	0.82790307
82	MP0001286_abnormal_eye_development	0.82752346
83	MP0002210_abnormal_sex_determination	0.81440934
84	MP0004924_abnormal_behavior	0.80913775
85	MP0005386_behavior/neurological_phenoty	0.80913775
86	MP0001919_abnormal_reproductive_system	0.80035643
87	MP0004147_increased_porphyrin_level	0.79391558
88	MP0001188_hyperpigmentation	0.76731459
89	MP0005171_absent_coat_pigmentation	0.76326008
90	MP0001502_abnormal_circadian_rhythm	0.75477213
91	MP0000639_abnormal_adrenal_gland	0.74868863
92	MP0008058_abnormal_DNA_repair	0.74502539
93	MP0001764_abnormal_homeostasis	0.73813751
94	MP0008569_lethality_at_weaning	0.73799708
95	MP0004043_abnormal_pH_regulation	0.73779304
96	MP0005253_abnormal_eye_physiology	0.73696781
97	MP0003937_abnormal_limbs/digits/tail_de	0.73508050
98	MP0005448_abnormal_energy_balance	0.70737675
99	MP0002066_abnormal_motor_capabilities/c	0.70362082
100	MP0001663_abnormal_digestive_system	0.68047089

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	6.31507998
2	Myokymia (HP:0002411)	4.43530740
3	Acute necrotizing encephalopathy (HP:0006965)	4.41922914
4	Pancreatic fibrosis (HP:0100732)	4.07806654
5	True hermaphroditism (HP:0010459)	3.99019976
6	Progressive macrocephaly (HP:0004481)	3.83085083
7	Agitation (HP:0000713)	3.76639257
8	Acute encephalopathy (HP:0006846)	3.72517706
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.66033564
10	Absent septum pellucidum (HP:0001331)	3.64355729
11	Type II lissencephaly (HP:0007260)	3.61819854
12	Molar tooth sign on MRI (HP:0002419)	3.47703402
13	Abnormality of midbrain morphology (HP:0002418)	3.47703402
14	Mitochondrial inheritance (HP:0001427)	3.42209293
15	Optic nerve hypoplasia (HP:0000609)	3.40356973
16	Focal motor seizures (HP:0011153)	3.32039313
17	Nephronophthisis (HP:0000090)	3.29487557
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.20929583
19	Pancreatic cysts (HP:0001737)	3.20358652
20	Retinal dysplasia (HP:0007973)	3.10523269
21	Progressive cerebellar ataxia (HP:0002073)	3.09453216
22	Abnormality of the septum pellucidum (HP:0007375)	3.06964689
23	Increased CSF lactate (HP:0002490)	3.06667218
24	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.00877649
25	Lissencephaly (HP:0001339)	2.98922891
26	Abnormality of cells of the erythroid lineage (HP:0012130)	2.96481615
27	Hepatocellular necrosis (HP:0001404)	2.92946756
28	Decreased central vision (HP:0007663)	2.92714695
29	Chronic hepatic failure (HP:0100626)	2.91335336
30	Optic disc pallor (HP:0000543)	2.89358683
31	Pendular nystagmus (HP:0012043)	2.87183684
32	Morphological abnormality of the inner ear (HP:0011390)	2.82569533
33	Sclerocornea (HP:0000647)	2.78631546
34	Hyperglycinemia (HP:0002154)	2.72364443
35	Poor suck (HP:0002033)	2.68772782
36	Abnormality of cochlea (HP:0000375)	2.65784424
37	Lipid accumulation in hepatocytes (HP:0006561)	2.63516647
38	Cerebral edema (HP:0002181)	2.53828794
39	Increased hepatocellular lipid droplets (HP:0006565)	2.51060140
40	Abnormality of the renal medulla (HP:0100957)	2.49523142
41	Restlessness (HP:0000711)	2.48602069
42	Growth hormone deficiency (HP:0000824)	2.42714012
43	Anencephaly (HP:0002323)	2.42523710
44	Hepatic necrosis (HP:0002605)	2.41255222
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.40577135
46	Reticulocytopenia (HP:0001896)	2.40264811
47	Cerebellar dysplasia (HP:0007033)	2.34244897
48	Enlarged penis (HP:0000040)	2.34092602
49	Abnormal number of erythroid precursors (HP:0012131)	2.28771057
50	Keratoconus (HP:0000563)	2.28376133
51	Increased corneal curvature (HP:0100692)	2.28376133
52	Pachygyria (HP:0001302)	2.28235780
53	Renal Fanconi syndrome (HP:0001994)	2.27599388
54	Irregular vertebral endplates (HP:0003301)	2.20933771
55	Limb dystonia (HP:0002451)	2.19799873
56	Confusion (HP:0001289)	2.17157374
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15010818
58	Cystic liver disease (HP:0006706)	2.12981448
59	Drooling (HP:0002307)	2.10608376
60	Genetic anticipation (HP:0003743)	2.10267993
61	Polyphagia (HP:0002591)	2.09514910
62	Medial flaring of the eyebrow (HP:0010747)	2.08603490
63	Abnormality of the labia minora (HP:0012880)	2.08548264
64	Constricted visual fields (HP:0001133)	2.04642906
65	Abolished electroretinogram (ERG) (HP:0000550)	2.04239211
66	Postaxial foot polydactyly (HP:0001830)	2.03198874
67	Focal seizures (HP:0007359)	2.01435529
68	Volvulus (HP:0002580)	1.99754909
69	Male pseudohermaphroditism (HP:0000037)	1.99255503
70	Prolonged partial thromboplastin time (HP:0003645)	1.96920835
71	Failure to thrive in infancy (HP:0001531)	1.96031214
72	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.95048742
73	Maternal diabetes (HP:0009800)	1.94599325
74	Abnormality of renal resorption (HP:0011038)	1.93999025
75	Attenuation of retinal blood vessels (HP:0007843)	1.93378202
76	Severe visual impairment (HP:0001141)	1.90455512
77	Excessive salivation (HP:0003781)	1.90139191
78	Stenosis of the external auditory canal (HP:0000402)	1.89607927
79	Leukodystrophy (HP:0002415)	1.88630887
80	Colon cancer (HP:0003003)	1.88616336
81	Hemiparesis (HP:0001269)	1.88330580
82	Gait imbalance (HP:0002141)	1.87565455
83	Abnormality of the vertebral endplates (HP:0005106)	1.85860110
84	Fetal akinesia sequence (HP:0001989)	1.83900307
85	Congenital hepatic fibrosis (HP:0002612)	1.83111856
86	Hyperthyroidism (HP:0000836)	1.82088248
87	Broad-based gait (HP:0002136)	1.80341868
88	Furrowed tongue (HP:0000221)	1.79608162
89	Macrocytic anemia (HP:0001972)	1.77445910
90	Anterior segment dysgenesis (HP:0007700)	1.75357009
91	Visual hallucinations (HP:0002367)	1.74557794
92	Anophthalmia (HP:0000528)	1.72755361
93	Abnormal hair whorl (HP:0010721)	1.72434130
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.72074877
95	Abnormal eating behavior (HP:0100738)	1.71891174
96	Hyperphosphatemia (HP:0002905)	1.71686592
97	Dandy-Walker malformation (HP:0001305)	1.71129260
98	Anxiety (HP:0000739)	1.69059294
99	Increased serum lactate (HP:0002151)	1.67787497
100	Parakeratosis (HP:0001036)	1.67560612

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	5.84696583
2	MARK1	4.44874451
3	INSRR	3.38541351
4	TLK1	3.07298460
5	NTRK2	2.73561601
6	FRK	2.70047488
7	CASK	2.59033078
8	MAP3K12	2.31449415
9	DYRK2	2.26768140
10	ZAK	2.25723857
11	SIK2	2.23015363
12	FGFR2	2.09346749
13	PAK3	1.94806811
14	BMPR1B	1.92514939
15	WNK3	1.88596757
16	MUSK	1.69316498
17	MAP2K7	1.65785081
18	NTRK3	1.65164680
19	GRK1	1.51120134
20	ADRBK2	1.40974581
21	CDC7	1.35999174
22	PNCK	1.35891299
23	DYRK1B	1.34351979
24	TNK2	1.33530459
25	PRKCG	1.29043780
26	PINK1	1.24087716
27	CSNK1G2	1.18745872
28	BCR	1.18522060
29	PIK3CA	1.18509123
30	MKNK2	1.16396052
31	MAP3K4	1.12928670
32	NLK	1.10036972
33	MAP2K4	1.08904046
34	TYRO3	1.08569312
35	MAPK13	1.06972647
36	EIF2AK3	1.06796603
37	DYRK1A	1.03990168
38	MAP3K11	1.01313418
39	MINK1	0.99956109
40	STK11	0.99467139
41	WNK4	0.98035330
42	CDK19	0.96264592
43	STK16	0.94397655
44	PRKD3	0.93994919
45	PRKCE	0.85047779
46	OXSR1	0.84521732
47	CSNK1G3	0.81701927
48	NME1	0.74008904
49	DYRK3	0.69705046
50	ADRBK1	0.68673002
51	MKNK1	0.66904737
52	PRKCZ	0.66156382
53	CSNK1G1	0.65671131
54	ERBB3	0.65547626
55	STK24	0.65197311
56	SGK223	0.63660927
57	SGK494	0.63660927
58	VRK2	0.60684641
59	EPHB2	0.59016256
60	EPHA4	0.58427330
61	PRKACA	0.58365919
62	CSNK1E	0.57655650
63	CSNK2A2	0.56333757
64	CSNK1A1L	0.54724636
65	AURKB	0.54341007
66	PRKCH	0.53696971
67	NTRK1	0.52678711
68	PRKDC	0.52276667
69	ATM	0.51265112
70	PRKCQ	0.49869497
71	CAMK1G	0.48931777
72	SGK2	0.48836356
73	VRK1	0.46916672
74	PRKACB	0.46707821
75	CSNK1A1	0.46214358
76	CAMK2A	0.45546176
77	PHKG1	0.45438006
78	PHKG2	0.45438006
79	MAP4K2	0.45345155
80	TIE1	0.44522872
81	CAMK1	0.41689055
82	CSNK2A1	0.40787270
83	NEK2	0.39501785
84	GRK5	0.39248441
85	PLK1	0.38570622
86	PRKG1	0.37542498
87	ABL2	0.36681203
88	OBSCN	0.36676122
89	ILK	0.35529624
90	PRKCA	0.35137366
91	CDK5	0.33639945
92	BLK	0.33149841
93	PLK2	0.33097862
94	CHEK2	0.32850192
95	MAPK4	0.32349057
96	SGK1	0.31953715
97	MAPKAPK5	0.30438975
98	ERBB2	0.29633185
99	ITK	0.28376330
100	CDK14	0.28114041

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.58515423
2	Parkinsons disease_Homo sapiens_hsa05012	4.09786275
3	Cardiac muscle contraction_Homo sapiens_hsa04260	3.49917262
4	Ribosome_Homo sapiens_hsa03010	3.10752419
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.07315881
6	Alzheimers disease_Homo sapiens_hsa05010	2.90756193
7	Huntingtons disease_Homo sapiens_hsa05016	2.73380080
8	Protein export_Homo sapiens_hsa03060	2.66185139
9	Nicotine addiction_Homo sapiens_hsa05033	2.57944706
10	Caffeine metabolism_Homo sapiens_hsa00232	2.41850820
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.38642371
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94208425
13	Asthma_Homo sapiens_hsa05310	1.89111848
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.79215624
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.61494120
16	Basal cell carcinoma_Homo sapiens_hsa05217	1.50440901
17	Butanoate metabolism_Homo sapiens_hsa00650	1.49392366
18	Phototransduction_Homo sapiens_hsa04744	1.48996707
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.46922777
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46120976
21	Cocaine addiction_Homo sapiens_hsa05030	1.42896463
22	Morphine addiction_Homo sapiens_hsa05032	1.42299362
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.32306887
24	Homologous recombination_Homo sapiens_hsa03440	1.25455954
25	Mismatch repair_Homo sapiens_hsa03430	1.24501293
26	RNA polymerase_Homo sapiens_hsa03020	1.22328346
27	Serotonergic synapse_Homo sapiens_hsa04726	1.21734222
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20620002
29	Insulin secretion_Homo sapiens_hsa04911	1.14776044
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12081556
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09622948
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.08745204
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.06531139
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04681514
35	GABAergic synapse_Homo sapiens_hsa04727	1.04005929
36	Retinol metabolism_Homo sapiens_hsa00830	1.01182537
37	Dopaminergic synapse_Homo sapiens_hsa04728	1.00090572
38	Folate biosynthesis_Homo sapiens_hsa00790	0.95885622
39	Circadian entrainment_Homo sapiens_hsa04713	0.93872469
40	Basal transcription factors_Homo sapiens_hsa03022	0.90965378
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90561790
42	Regulation of autophagy_Homo sapiens_hsa04140	0.89152342
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88362574
44	Taste transduction_Homo sapiens_hsa04742	0.88240107
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87147814
46	Olfactory transduction_Homo sapiens_hsa04740	0.82109797
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81362579
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.77690729
49	Proteasome_Homo sapiens_hsa03050	0.77387029
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74099003
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73427077
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71558549
53	Cholinergic synapse_Homo sapiens_hsa04725	0.71418186
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.70387763
55	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.70288960
56	Amphetamine addiction_Homo sapiens_hsa05031	0.70241189
57	Propanoate metabolism_Homo sapiens_hsa00640	0.67786509
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67749292
59	Peroxisome_Homo sapiens_hsa04146	0.65853632
60	Mineral absorption_Homo sapiens_hsa04978	0.65248115
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65227630
62	Salivary secretion_Homo sapiens_hsa04970	0.65175839
63	Long-term depression_Homo sapiens_hsa04730	0.64892112
64	Fatty acid elongation_Homo sapiens_hsa00062	0.64365850
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63902633
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62209844
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59717009
68	Metabolic pathways_Homo sapiens_hsa01100	0.58885552
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58165412
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57427903
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.55176576
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54979950
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.54754118
74	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54002387
75	Axon guidance_Homo sapiens_hsa04360	0.53255068
76	Melanogenesis_Homo sapiens_hsa04916	0.52557236
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.52129954
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50661549
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.50214899
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.49802178
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.48874363
82	Bile secretion_Homo sapiens_hsa04976	0.48855445
83	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.47869204
84	Allograft rejection_Homo sapiens_hsa05330	0.47537249
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46874259
86	Fatty acid degradation_Homo sapiens_hsa00071	0.45651399
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.42049749
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41158941
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.38283518
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37922873
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.36236631
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35920218
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34638520
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33429525
95	Renin secretion_Homo sapiens_hsa04924	0.33422967
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31670826
97	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.31648463
98	DNA replication_Homo sapiens_hsa03030	0.30657705
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30595446
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30550741

CDH12P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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