CDH12P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kidney morphogenesis (GO:0060993)6.33445387
2pyrimidine nucleobase catabolic process (GO:0006208)5.42783664
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.07710848
4ATP synthesis coupled proton transport (GO:0015986)4.99772395
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.99772395
6nucleobase catabolic process (GO:0046113)4.41770149
7behavioral response to nicotine (GO:0035095)4.30246308
8lung-associated mesenchyme development (GO:0060484)4.27900184
9spinal cord association neuron differentiation (GO:0021527)4.19141373
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17420135
11metanephric tubule development (GO:0072170)4.04975657
12metanephric nephron tubule development (GO:0072234)4.04975657
13lung epithelium development (GO:0060428)4.03394828
14sequestering of actin monomers (GO:0042989)4.00902528
15collecting duct development (GO:0072044)3.99570991
16transmission of nerve impulse (GO:0019226)3.95731117
17lens fiber cell development (GO:0070307)3.93588352
18dendritic spine morphogenesis (GO:0060997)3.88013543
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.87735604
20respiratory tube development (GO:0030323)3.75245384
21respiratory electron transport chain (GO:0022904)3.73476114
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68731319
23adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.68626080
24electron transport chain (GO:0022900)3.67476470
25neuron recognition (GO:0008038)3.52692442
26retinal ganglion cell axon guidance (GO:0031290)3.48342528
27cartilage morphogenesis (GO:0060536)3.47924486
28auditory receptor cell differentiation (GO:0042491)3.43102575
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41417412
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.41417412
31NADH dehydrogenase complex assembly (GO:0010257)3.41417412
32metanephric nephron epithelium development (GO:0072243)3.41157972
33ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.36390352
34water-soluble vitamin biosynthetic process (GO:0042364)3.35358577
35axon extension (GO:0048675)3.30970388
36opioid receptor signaling pathway (GO:0038003)3.29061213
37viral transcription (GO:0019083)3.19737490
38protein localization to cilium (GO:0061512)3.17751297
39translational termination (GO:0006415)3.15985489
40protein complex biogenesis (GO:0070271)3.14545907
41cell proliferation in forebrain (GO:0021846)3.13421273
42metanephric epithelium development (GO:0072207)3.11706513
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.08549372
44cerebral cortex radially oriented cell migration (GO:0021799)2.98000661
45protein neddylation (GO:0045116)2.97533550
46positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.96258439
47intraciliary transport (GO:0042073)2.94802304
48presynaptic membrane assembly (GO:0097105)2.92643789
49replication fork processing (GO:0031297)2.92183838
50central nervous system projection neuron axonogenesis (GO:0021952)2.89800338
51cell differentiation in spinal cord (GO:0021515)2.89765296
52dentate gyrus development (GO:0021542)2.89331633
53postsynaptic membrane organization (GO:0001941)2.88745624
54central nervous system myelination (GO:0022010)2.87710694
55axon ensheathment in central nervous system (GO:0032291)2.87710694
56hydrogen ion transmembrane transport (GO:1902600)2.85917370
57nonmotile primary cilium assembly (GO:0035058)2.84848933
58protein polyglutamylation (GO:0018095)2.84710147
59pituitary gland development (GO:0021983)2.84057908
60positive regulation of sodium ion transmembrane transport (GO:1902307)2.84018851
61ATP biosynthetic process (GO:0006754)2.83936542
62axonal fasciculation (GO:0007413)2.77729103
63neuronal action potential (GO:0019228)2.77253518
64forebrain neuron differentiation (GO:0021879)2.73624709
65cotranslational protein targeting to membrane (GO:0006613)2.72193248
66protein targeting to ER (GO:0045047)2.71942376
67kynurenine metabolic process (GO:0070189)2.71028307
68membrane hyperpolarization (GO:0060081)2.70134951
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69494739
70anatomical structure regression (GO:0060033)2.69222351
71mitochondrial respiratory chain complex assembly (GO:0033108)2.67856031
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67105182
73appendage development (GO:0048736)2.66975934
74limb development (GO:0060173)2.66975934
75glycerophospholipid catabolic process (GO:0046475)2.65460394
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65348383
77Sertoli cell development (GO:0060009)2.64718673
78negative regulation of smooth muscle cell differentiation (GO:0051151)2.63387935
79negative regulation of membrane potential (GO:0045837)2.62097729
80response to dietary excess (GO:0002021)2.60531429
81protein-cofactor linkage (GO:0018065)2.57312693
82negative regulation of astrocyte differentiation (GO:0048712)2.57270447
83respiratory chain complex IV assembly (GO:0008535)2.56717877
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56532790
85protein localization to endoplasmic reticulum (GO:0070972)2.55290775
86thalamus development (GO:0021794)2.55024409
87neuronal action potential propagation (GO:0019227)2.54673391
88tryptophan catabolic process (GO:0006569)2.54258884
89indole-containing compound catabolic process (GO:0042436)2.54258884
90indolalkylamine catabolic process (GO:0046218)2.54258884
91lung morphogenesis (GO:0060425)2.53872345
92synapse assembly (GO:0007416)2.53033968
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53019091
94proton transport (GO:0015992)2.51915640
95positive regulation of synapse assembly (GO:0051965)2.51242250
96nephron tubule development (GO:0072080)2.50839500
97translational elongation (GO:0006414)2.50018110
98hindbrain development (GO:0030902)2.49936180
99hydrogen transport (GO:0006818)2.49096361
100somite development (GO:0061053)2.48996168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26046150
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.72877053
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.70948120
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26056902
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.95269468
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.90002618
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83093325
8TAF15_26573619_Chip-Seq_HEK293_Human2.48924790
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36672727
10GBX2_23144817_ChIP-Seq_PC3_Human2.35656402
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.28341579
12REST_21632747_ChIP-Seq_MESCs_Mouse2.25375812
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24950585
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24929656
15VDR_22108803_ChIP-Seq_LS180_Human2.22847299
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22696834
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19173429
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14507236
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.11773444
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05259590
21FUS_26573619_Chip-Seq_HEK293_Human2.02942304
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96293422
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95285224
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90284527
25IGF1R_20145208_ChIP-Seq_DFB_Human1.87008487
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77506142
27RNF2_27304074_Chip-Seq_NSC_Mouse1.76414108
28EWS_26573619_Chip-Seq_HEK293_Human1.74882040
29P300_19829295_ChIP-Seq_ESCs_Human1.73177272
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.66601989
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66498727
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60133724
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60038877
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57615146
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57615146
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56867627
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.56730414
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52461005
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.50577780
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49406165
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49190674
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47478270
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47478270
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.47088738
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45764614
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42070014
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42058869
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41346620
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39028391
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36228635
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34279257
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29652730
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28710920
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27937044
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27555961
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26630804
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26258839
58BCAT_22108803_ChIP-Seq_LS180_Human1.23706029
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23489639
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23336340
61CBP_20019798_ChIP-Seq_JUKART_Human1.22176650
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22176650
63ER_23166858_ChIP-Seq_MCF-7_Human1.21680754
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21066981
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.20830452
66DROSHA_22980978_ChIP-Seq_HELA_Human1.20760572
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18876459
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15450354
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15443679
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14672369
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14262569
72SMAD4_21799915_ChIP-Seq_A2780_Human1.13756992
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13334904
74AR_25329375_ChIP-Seq_VCAP_Human1.10183414
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09115156
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.07371780
77IRF1_19129219_ChIP-ChIP_H3396_Human1.05236416
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.04902725
79TCF4_23295773_ChIP-Seq_U87_Human1.04503038
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03509911
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02325008
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.01129982
83RUNX2_22187159_ChIP-Seq_PCA_Human1.00848342
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00701374
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99114888
86TP53_22573176_ChIP-Seq_HFKS_Human0.98764521
87STAT3_23295773_ChIP-Seq_U87_Human0.98337564
88NCOR_22424771_ChIP-Seq_293T_Human0.97087707
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.95970085
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95653071
91JUN_21703547_ChIP-Seq_K562_Human0.93978226
92GABP_17652178_ChIP-ChIP_JURKAT_Human0.93970362
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93083113
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92840039
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.92659961
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90670579
97TCF4_22108803_ChIP-Seq_LS180_Human0.89899650
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89089101
99MYC_18940864_ChIP-ChIP_HL60_Human0.88764101
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88363613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.80799236
2MP0003122_maternal_imprinting3.35108796
3MP0009379_abnormal_foot_pigmentation3.27237681
4MP0006292_abnormal_olfactory_placode3.22381136
5MP0003121_genomic_imprinting2.83652604
6MP0005646_abnormal_pituitary_gland2.59389550
7MP0000566_synostosis2.58967557
8MP0008877_abnormal_DNA_methylation2.42491864
9MP0000778_abnormal_nervous_system2.34349647
10MP0002837_dystrophic_cardiac_calcinosis2.31637587
11MP0003123_paternal_imprinting2.25740531
12MP0010030_abnormal_orbit_morphology2.09984368
13MP0003283_abnormal_digestive_organ1.93762381
14MP0004885_abnormal_endolymph1.92394100
15MP0006276_abnormal_autonomic_nervous1.89130115
16MP0005084_abnormal_gallbladder_morpholo1.85498342
17MP0004742_abnormal_vestibular_system1.83830932
18MP0000631_abnormal_neuroendocrine_gland1.77518354
19MP0002102_abnormal_ear_morphology1.70248964
20MP0002938_white_spotting1.68671544
21MP0005551_abnormal_eye_electrophysiolog1.67906703
22MP0001485_abnormal_pinna_reflex1.67094276
23MP0001346_abnormal_lacrimal_gland1.63316005
24MP0001529_abnormal_vocalization1.60673379
25MP0002272_abnormal_nervous_system1.59031570
26MP0001986_abnormal_taste_sensitivity1.58192947
27MP0008789_abnormal_olfactory_epithelium1.55676834
28MP0004145_abnormal_muscle_electrophysio1.54793878
29MP0009745_abnormal_behavioral_response1.54038190
30MP0002653_abnormal_ependyma_morphology1.53918287
31MP0004142_abnormal_muscle_tone1.53843098
32MP0002734_abnormal_mechanical_nocicepti1.52188781
33MP0008875_abnormal_xenobiotic_pharmacok1.51338671
34MP0003938_abnormal_ear_development1.47652082
35MP0006072_abnormal_retinal_apoptosis1.47394766
36MP0001968_abnormal_touch/_nociception1.44536921
37MP0000955_abnormal_spinal_cord1.44134152
38MP0005499_abnormal_olfactory_system1.43604292
39MP0005394_taste/olfaction_phenotype1.43604292
40MP0008872_abnormal_physiological_respon1.43199964
41MP0001293_anophthalmia1.42458277
42MP0004859_abnormal_synaptic_plasticity1.41837347
43MP0001486_abnormal_startle_reflex1.40753884
44MP0005248_abnormal_Harderian_gland1.40645791
45MP0001905_abnormal_dopamine_level1.37242898
46MP0002064_seizures1.35586238
47MP0005195_abnormal_posterior_eye1.34426531
48MP0002557_abnormal_social/conspecific_i1.32678599
49MP0003635_abnormal_synaptic_transmissio1.32316896
50MP0004133_heterotaxia1.31366291
51MP0001984_abnormal_olfaction1.30213036
52MP0002876_abnormal_thyroid_physiology1.27426912
53MP0002067_abnormal_sensory_capabilities1.25609321
54MP0002733_abnormal_thermal_nociception1.23925107
55MP0002572_abnormal_emotion/affect_behav1.23691756
56MP0002928_abnormal_bile_duct1.23612972
57MP0002063_abnormal_learning/memory/cond1.23266653
58MP0002735_abnormal_chemical_nociception1.20327386
59MP0004270_analgesia1.20157568
60MP0002736_abnormal_nociception_after1.17231917
61MP0000372_irregular_coat_pigmentation1.15883947
62MP0001970_abnormal_pain_threshold1.15231450
63MP0003880_abnormal_central_pattern1.15230915
64MP0009046_muscle_twitch1.12445242
65MP0001440_abnormal_grooming_behavior1.11640000
66MP0002752_abnormal_somatic_nervous1.10156440
67MP0003878_abnormal_ear_physiology1.07211319
68MP0005377_hearing/vestibular/ear_phenot1.07211319
69MP0002234_abnormal_pharynx_morphology1.06936701
70MP0000026_abnormal_inner_ear1.05238329
71MP0000049_abnormal_middle_ear0.99286301
72MP0001963_abnormal_hearing_physiology0.95358974
73MP0002882_abnormal_neuron_morphology0.95264699
74MP0003937_abnormal_limbs/digits/tail_de0.93807674
75MP0002152_abnormal_brain_morphology0.90190934
76MP0005386_behavior/neurological_phenoty0.88513026
77MP0004924_abnormal_behavior0.88513026
78MP0003252_abnormal_bile_duct0.88460909
79MP0001188_hyperpigmentation0.88323486
80MP0001919_abnormal_reproductive_system0.87587527
81MP0002184_abnormal_innervation0.87465105
82MP0009384_cardiac_valve_regurgitation0.85505960
83MP0001286_abnormal_eye_development0.83004116
84MP0001324_abnormal_eye_pigmentation0.82783702
85MP0004147_increased_porphyrin_level0.81567049
86MP0003646_muscle_fatigue0.80772160
87MP0000569_abnormal_digit_pigmentation0.80385033
88MP0005379_endocrine/exocrine_gland_phen0.79018074
89MP0009053_abnormal_anal_canal0.78227643
90MP0002233_abnormal_nose_morphology0.76405852
91MP0005389_reproductive_system_phenotype0.75868621
92MP0005332_abnormal_amino_acid0.75692170
93MP0003567_abnormal_fetal_cardiomyocyte0.75633102
94MP0004043_abnormal_pH_regulation0.75475441
95MP0002210_abnormal_sex_determination0.74529544
96MP0001764_abnormal_homeostasis0.74264544
97MP0002163_abnormal_gland_morphology0.73713645
98MP0003195_calcinosis0.73183147
99MP0009250_abnormal_appendicular_skeleto0.73159380
100MP0002066_abnormal_motor_capabilities/c0.70630302

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.45625164
2True hermaphroditism (HP:0010459)4.13567328
3Pancreatic fibrosis (HP:0100732)4.12539984
4Acute necrotizing encephalopathy (HP:0006965)4.07639059
5Type II lissencephaly (HP:0007260)4.02141132
6Myokymia (HP:0002411)3.93364736
7Progressive macrocephaly (HP:0004481)3.65972757
8Abnormality of midbrain morphology (HP:0002418)3.56709461
9Molar tooth sign on MRI (HP:0002419)3.56709461
10Agitation (HP:0000713)3.46473618
11Acute encephalopathy (HP:0006846)3.38734149
12Abnormal mitochondria in muscle tissue (HP:0008316)3.33615653
13Pancreatic cysts (HP:0001737)3.31655668
14Lissencephaly (HP:0001339)3.31371504
15Nephronophthisis (HP:0000090)3.26512240
16Mitochondrial inheritance (HP:0001427)3.21523663
17Optic nerve hypoplasia (HP:0000609)3.19702502
18Retinal dysplasia (HP:0007973)3.16584357
19Absent septum pellucidum (HP:0001331)3.09607087
20Pendular nystagmus (HP:0012043)3.04334458
21Focal motor seizures (HP:0011153)3.03234996
22Cerebellar dysplasia (HP:0007033)2.93912368
23Decreased central vision (HP:0007663)2.93501471
24Optic disc pallor (HP:0000543)2.91893857
25Chronic hepatic failure (HP:0100626)2.91353090
26Hyperglycinemia (HP:0002154)2.90140198
27Increased CSF lactate (HP:0002490)2.89741819
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87692104
29Sclerocornea (HP:0000647)2.82972718
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.80633551
31Volvulus (HP:0002580)2.76753128
32Progressive cerebellar ataxia (HP:0002073)2.73680106
33Hepatocellular necrosis (HP:0001404)2.66573620
34Poor suck (HP:0002033)2.62428927
35Abnormality of the renal medulla (HP:0100957)2.58248626
36Abnormality of the septum pellucidum (HP:0007375)2.56198214
37Lipid accumulation in hepatocytes (HP:0006561)2.55040966
38Cerebral edema (HP:0002181)2.52513460
39Increased hepatocellular lipid droplets (HP:0006565)2.52255887
40Morphological abnormality of the inner ear (HP:0011390)2.51680719
41Pachygyria (HP:0001302)2.50041058
42Limb dystonia (HP:0002451)2.45373092
43Abnormality of cells of the erythroid lineage (HP:0012130)2.44132447
44Growth hormone deficiency (HP:0000824)2.43469618
45Anencephaly (HP:0002323)2.41999522
46Abnormal rod and cone electroretinograms (HP:0008323)2.34080840
47Abnormality of cochlea (HP:0000375)2.32424254
48Abnormal hair whorl (HP:0010721)2.29548062
49Drooling (HP:0002307)2.27396470
50Abnormality of the labia minora (HP:0012880)2.25260267
51Keratoconus (HP:0000563)2.25031432
52Increased corneal curvature (HP:0100692)2.25031432
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.24170769
54Hepatic necrosis (HP:0002605)2.22404872
55Cystic liver disease (HP:0006706)2.21921064
56Severe visual impairment (HP:0001141)2.21348774
57Restlessness (HP:0000711)2.20815763
58Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20516348
59Renal Fanconi syndrome (HP:0001994)2.19913881
60Abolished electroretinogram (ERG) (HP:0000550)2.15395296
61Maternal diabetes (HP:0009800)2.15281982
62Enlarged penis (HP:0000040)2.13593052
63Male pseudohermaphroditism (HP:0000037)2.11332982
64Postaxial foot polydactyly (HP:0001830)2.09299822
65Medial flaring of the eyebrow (HP:0010747)2.09299573
66Focal seizures (HP:0007359)2.06111509
67Congenital hepatic fibrosis (HP:0002612)2.06103629
68Excessive salivation (HP:0003781)2.05950908
69Colon cancer (HP:0003003)2.04041546
70Exertional dyspnea (HP:0002875)2.03717813
71Constricted visual fields (HP:0001133)2.03248835
72Attenuation of retinal blood vessels (HP:0007843)2.00053954
73Reticulocytopenia (HP:0001896)1.99559106
74Anophthalmia (HP:0000528)1.95634711
75Furrowed tongue (HP:0000221)1.92261900
76Irregular vertebral endplates (HP:0003301)1.91759720
77Polyphagia (HP:0002591)1.90095313
78Truncal obesity (HP:0001956)1.89002436
79Genetic anticipation (HP:0003743)1.88642964
80Leukodystrophy (HP:0002415)1.87736911
81Abnormality of renal resorption (HP:0011038)1.84467317
82Abnormal number of erythroid precursors (HP:0012131)1.83648177
83Anterior segment dysgenesis (HP:0007700)1.79365061
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78526895
85Holoprosencephaly (HP:0001360)1.76661679
86Broad-based gait (HP:0002136)1.75205371
87Fetal akinesia sequence (HP:0001989)1.75080238
88Gait imbalance (HP:0002141)1.75026861
89Failure to thrive in infancy (HP:0001531)1.73754753
90Preaxial hand polydactyly (HP:0001177)1.73706886
91Dandy-Walker malformation (HP:0001305)1.72456543
92Hemiparesis (HP:0001269)1.72053457
93Abnormality of macular pigmentation (HP:0008002)1.71562270
94Hyperglycinuria (HP:0003108)1.70729209
95Confusion (HP:0001289)1.70610364
96Postaxial hand polydactyly (HP:0001162)1.70043208
97Dyschromatopsia (HP:0007641)1.67799224
98Protruding tongue (HP:0010808)1.67486631
99Abnormality of the vitreous humor (HP:0004327)1.65739596
100Hypothermia (HP:0002045)1.65565230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.13213257
2MARK14.69878543
3FRK3.68182985
4CASK2.95282364
5INSRR2.90998621
6TLK12.81173340
7NTRK22.39888558
8DYRK22.30212212
9FGFR22.25111940
10MAP3K122.23571800
11ZAK2.03891396
12BMPR1B1.91947629
13PAK31.90980836
14WNK31.87442106
15MAP2K71.71357833
16EIF2AK31.69019729
17SIK21.66096196
18ADRBK21.63243105
19TNK21.50475535
20MAPK131.46170546
21DYRK1B1.41982217
22PNCK1.40685325
23MUSK1.39530539
24GRK11.38556701
25PINK11.37405099
26MAP3K41.31869752
27MAP2K41.31623556
28NTRK31.31290781
29MAP4K21.25448348
30OXSR11.15606349
31PRKCG1.15325178
32CDK191.12073843
33CSNK1G21.10911087
34ERBB31.05184472
35PRKD31.02238892
36WNK40.99872452
37MKNK20.97533057
38CDC70.97028786
39MINK10.96417320
40MAP3K110.94194662
41STK160.93340647
42STK110.92740208
43DYRK1A0.92007837
44MKNK10.91920308
45BCR0.86026519
46PRKCE0.84989788
47PIK3CA0.84367712
48TAF10.82907257
49ADRBK10.81206544
50TIE10.79669788
51NLK0.78738702
52CSNK1G30.71045473
53TYRO30.67748146
54VRK10.67358754
55PLK20.63374706
56GRK50.60993987
57CSNK1G10.60760600
58PRKCH0.58792399
59PRKCZ0.57940976
60SGK2230.57427046
61SGK4940.57427046
62STK240.56739009
63PRKACA0.56350101
64EPHB20.55115360
65IRAK10.53963989
66CSNK1E0.52758237
67EPHA40.51673356
68VRK20.49809878
69MAP2K60.49796480
70ATM0.49026507
71CSNK1A10.47836489
72NUAK10.47727050
73SGK20.47566918
74CSNK2A20.47360847
75PRKACB0.43612613
76CSNK1A1L0.43480599
77PRKCQ0.42870803
78CDK50.42025522
79PRKDC0.41666233
80AURKB0.41353076
81PRKG10.38292964
82CAMK10.37739305
83CAMK2A0.37504298
84DYRK30.36846543
85IRAK20.36638193
86PLK40.36163593
87MAPKAPK50.36037278
88AKT30.34556741
89NTRK10.34052460
90TEC0.33798440
91TGFBR10.33672070
92SGK10.32446835
93PRKCA0.31815297
94CDK11A0.31687660
95CSNK2A10.31033187
96PLK30.30677024
97PLK10.30306805
98CDK150.30004790
99CDK140.29316103
100MAPK40.28226291

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.32223302
2Parkinsons disease_Homo sapiens_hsa050123.78383168
3Cardiac muscle contraction_Homo sapiens_hsa042603.10367392
4Ribosome_Homo sapiens_hsa030102.93516136
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.87395197
6Protein export_Homo sapiens_hsa030602.70679017
7Alzheimers disease_Homo sapiens_hsa050102.64526851
8Caffeine metabolism_Homo sapiens_hsa002322.63267378
9Nicotine addiction_Homo sapiens_hsa050332.58808355
10Huntingtons disease_Homo sapiens_hsa050162.49854438
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13292780
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07188907
13Asthma_Homo sapiens_hsa053102.00191169
14Linoleic acid metabolism_Homo sapiens_hsa005911.91474194
15Phototransduction_Homo sapiens_hsa047441.63289282
16Butanoate metabolism_Homo sapiens_hsa006501.60687713
17Basal cell carcinoma_Homo sapiens_hsa052171.60190366
18Hedgehog signaling pathway_Homo sapiens_hsa043401.56642437
19Steroid biosynthesis_Homo sapiens_hsa001001.52745612
20Cocaine addiction_Homo sapiens_hsa050301.37545869
21Morphine addiction_Homo sapiens_hsa050321.33181106
22Glutamatergic synapse_Homo sapiens_hsa047241.30508255
23RNA polymerase_Homo sapiens_hsa030201.25257551
24Tryptophan metabolism_Homo sapiens_hsa003801.25119741
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24623543
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24526835
27Insulin secretion_Homo sapiens_hsa049111.24427778
28Propanoate metabolism_Homo sapiens_hsa006401.24125982
29Homologous recombination_Homo sapiens_hsa034401.24058306
30Serotonergic synapse_Homo sapiens_hsa047261.23562128
31Folate biosynthesis_Homo sapiens_hsa007901.22911542
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21218358
33Basal transcription factors_Homo sapiens_hsa030221.20953338
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19040137
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.16992040
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15739061
37Regulation of autophagy_Homo sapiens_hsa041401.14837863
38Mismatch repair_Homo sapiens_hsa034301.13157534
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11103533
40Dopaminergic synapse_Homo sapiens_hsa047281.06121245
41GABAergic synapse_Homo sapiens_hsa047271.01875263
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00835327
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00134973
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98897667
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.93964703
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91371958
47Taste transduction_Homo sapiens_hsa047420.90967846
48Retinol metabolism_Homo sapiens_hsa008300.89998865
49Olfactory transduction_Homo sapiens_hsa047400.87453041
50Nucleotide excision repair_Homo sapiens_hsa034200.85369719
51Circadian entrainment_Homo sapiens_hsa047130.83558428
52Type I diabetes mellitus_Homo sapiens_hsa049400.81930426
53Chemical carcinogenesis_Homo sapiens_hsa052040.81725063
54Long-term depression_Homo sapiens_hsa047300.77540560
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76876347
56Selenocompound metabolism_Homo sapiens_hsa004500.75346444
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74609011
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74275125
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.73335212
60Salivary secretion_Homo sapiens_hsa049700.70260060
61Cholinergic synapse_Homo sapiens_hsa047250.69897111
62Ether lipid metabolism_Homo sapiens_hsa005650.69481547
63Peroxisome_Homo sapiens_hsa041460.69304482
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69141048
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68497671
66Fanconi anemia pathway_Homo sapiens_hsa034600.67798219
67Fat digestion and absorption_Homo sapiens_hsa049750.67029432
68Mineral absorption_Homo sapiens_hsa049780.65766435
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64171645
70Ovarian steroidogenesis_Homo sapiens_hsa049130.61039763
71Metabolic pathways_Homo sapiens_hsa011000.60261180
72Fatty acid metabolism_Homo sapiens_hsa012120.60088131
73Amphetamine addiction_Homo sapiens_hsa050310.59718020
74Graft-versus-host disease_Homo sapiens_hsa053320.59051998
75Fatty acid degradation_Homo sapiens_hsa000710.55514748
76Fatty acid elongation_Homo sapiens_hsa000620.54943114
77Proteasome_Homo sapiens_hsa030500.52470316
78Autoimmune thyroid disease_Homo sapiens_hsa053200.51311748
79Allograft rejection_Homo sapiens_hsa053300.49561596
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47870329
81Non-homologous end-joining_Homo sapiens_hsa034500.47057903
82Arachidonic acid metabolism_Homo sapiens_hsa005900.46724680
83Axon guidance_Homo sapiens_hsa043600.45810182
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44653811
85Wnt signaling pathway_Homo sapiens_hsa043100.43711938
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42899688
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39193679
88Melanogenesis_Homo sapiens_hsa049160.36695976
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36483039
90Staphylococcus aureus infection_Homo sapiens_hsa051500.36056424
91Nitrogen metabolism_Homo sapiens_hsa009100.34394896
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32203433
93Pyrimidine metabolism_Homo sapiens_hsa002400.31197462
94One carbon pool by folate_Homo sapiens_hsa006700.28994645
95Purine metabolism_Homo sapiens_hsa002300.28742379
96Synaptic vesicle cycle_Homo sapiens_hsa047210.28216567
97Oxytocin signaling pathway_Homo sapiens_hsa049210.27964746
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27183420
99Hippo signaling pathway_Homo sapiens_hsa043900.26830470
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.25872643

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