CDH13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.64642112
2cell adhesion mediated by integrin (GO:0033627)4.52397363
3endodermal cell differentiation (GO:0035987)4.50802814
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.32500726
5vocalization behavior (GO:0071625)4.15144121
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.05539649
7collagen fibril organization (GO:0030199)4.04609266
8cell-substrate junction assembly (GO:0007044)4.04465211
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.02261695
10regulation of synapse structural plasticity (GO:0051823)4.00864317
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90605869
12sarcomere organization (GO:0045214)3.89179913
13plasma membrane repair (GO:0001778)3.88309580
14regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.86805032
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.85388485
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.82654369
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80819182
18lymphangiogenesis (GO:0001946)3.76312097
19neuron cell-cell adhesion (GO:0007158)3.74456329
20synaptic vesicle exocytosis (GO:0016079)3.73165221
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.72728305
22regulation of glutamate receptor signaling pathway (GO:1900449)3.71717950
23cardiac myofibril assembly (GO:0055003)3.70610208
24regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.67633222
25desmosome organization (GO:0002934)3.59825459
26locomotory exploration behavior (GO:0035641)3.55805241
27regulation of cell communication by electrical coupling (GO:0010649)3.54796830
28synaptic vesicle maturation (GO:0016188)3.54015728
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.51502271
30chondrocyte proliferation (GO:0035988)3.46040535
31activation of protein kinase A activity (GO:0034199)3.43002679
32response to gravity (GO:0009629)3.42080475
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41422049
34regulation of membrane repolarization (GO:0060306)3.39920867
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38846203
36sequestering of extracellular ligand from receptor (GO:0035581)3.35422932
37cardiac muscle contraction (GO:0060048)3.35014012
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31500017
39protein heterotrimerization (GO:0070208)3.30958961
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30327335
41actin-myosin filament sliding (GO:0033275)3.30240296
42muscle filament sliding (GO:0030049)3.30240296
43glutamate secretion (GO:0014047)3.29983717
44layer formation in cerebral cortex (GO:0021819)3.29787926
45negative regulation of nitric-oxide synthase activity (GO:0051001)3.29088026
46cell communication involved in cardiac conduction (GO:0086065)3.28830954
47negative regulation of chondrocyte differentiation (GO:0032331)3.27006912
48detection of calcium ion (GO:0005513)3.25432179
49muscle cell cellular homeostasis (GO:0046716)3.24075661
50substrate-dependent cell migration (GO:0006929)3.23963904
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23420225
52myofibril assembly (GO:0030239)3.21570364
53protein localization to synapse (GO:0035418)3.20000949
54cell migration involved in heart development (GO:0060973)3.17496833
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16978820
56negative regulation of protein localization to cell surface (GO:2000009)3.15442779
57sarcoplasmic reticulum calcium ion transport (GO:0070296)3.15139233
58negative regulation of axon extension involved in axon guidance (GO:0048843)3.14571512
59cell communication by electrical coupling (GO:0010644)3.13613965
60skin morphogenesis (GO:0043589)3.13016745
61neuron recognition (GO:0008038)3.11889235
62regulation of synaptic vesicle exocytosis (GO:2000300)3.11881372
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.11309993
64regulation of relaxation of muscle (GO:1901077)3.10927459
65exploration behavior (GO:0035640)3.09624807
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.08845873
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08756327
68regulation of actin filament-based movement (GO:1903115)3.08673257
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.08384368
70tricarboxylic acid cycle (GO:0006099)3.07780943
71postsynaptic membrane organization (GO:0001941)3.04654492
72neurotransmitter secretion (GO:0007269)3.03709912
73dendritic spine morphogenesis (GO:0060997)3.03387845
74response to muscle activity (GO:0014850)3.00940237
75regulation of integrin-mediated signaling pathway (GO:2001044)3.00552558
76kidney mesenchyme development (GO:0072074)2.99607437
77regulation of axon extension involved in axon guidance (GO:0048841)2.97953131
78wound healing, spreading of epidermal cells (GO:0035313)2.97481733
79prepulse inhibition (GO:0060134)2.96209820
80retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95832459
81neurotransmitter-gated ion channel clustering (GO:0072578)2.95709307
82actin filament depolymerization (GO:0030042)2.95489742
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.94930629
84ionotropic glutamate receptor signaling pathway (GO:0035235)2.94769418
85regulation of calcium ion transmembrane transporter activity (GO:1901019)2.94494072
86regulation of calcium ion transmembrane transport (GO:1903169)2.94494072
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92299216
88extracellular matrix assembly (GO:0085029)2.90975756
89ventricular cardiac muscle cell action potential (GO:0086005)2.90470595
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88077612
91positive regulation of potassium ion transmembrane transport (GO:1901381)2.86877481
92substrate adhesion-dependent cell spreading (GO:0034446)2.86383159
93metanephric mesenchyme development (GO:0072075)2.85292115
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84292011
95extracellular fibril organization (GO:0043206)2.83962038
96striated muscle contraction (GO:0006941)2.82669539
97cardiac conduction (GO:0061337)2.81315093
98heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.80227538
99neuron-neuron synaptic transmission (GO:0007270)2.80170804
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79908503
101regulation of synaptic vesicle transport (GO:1902803)2.79372076
102regulation of skeletal muscle contraction (GO:0014819)2.78330743
103proline transport (GO:0015824)2.77137799
104regulation of heart rate by cardiac conduction (GO:0086091)2.76965417
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76768742
106actin-mediated cell contraction (GO:0070252)2.76646860
107vascular endothelial growth factor signaling pathway (GO:0038084)2.75954766
108regulation of transforming growth factor beta2 production (GO:0032909)2.75941996
109negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75457972
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.75024786
111axonal fasciculation (GO:0007413)2.74402888
112actin filament-based movement (GO:0030048)2.71974155
113extracellular matrix disassembly (GO:0022617)2.71119857
114regulation of striated muscle contraction (GO:0006942)2.70619765
115membrane assembly (GO:0071709)2.69422916
116negative regulation of potassium ion transport (GO:0043267)2.69361143
117cell migration in hindbrain (GO:0021535)2.68182738
118glutamate receptor signaling pathway (GO:0007215)2.67317506
119cellular response to vitamin (GO:0071295)2.67274144
120positive regulation of action potential (GO:0045760)2.66018171
121cardiac muscle cell action potential (GO:0086001)2.65523197
122collagen metabolic process (GO:0032963)2.65345804
123synaptic transmission, glutamatergic (GO:0035249)2.64686186
124negative regulation of keratinocyte proliferation (GO:0010839)2.64576728
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.64381130
126cardiac muscle cell action potential involved in contraction (GO:0086002)2.63727081
127gamma-aminobutyric acid transport (GO:0015812)2.63262851
128neuronal action potential propagation (GO:0019227)2.62829956
129dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61876150
130regulation of axon guidance (GO:1902667)2.61668275
131regulation of the force of heart contraction (GO:0002026)2.60599555
132collagen catabolic process (GO:0030574)2.59851585
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.59552649
134multicellular organismal signaling (GO:0035637)2.58861294
135cardiac muscle hypertrophy (GO:0003300)2.58679628
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58549191
137extracellular matrix organization (GO:0030198)2.58111368
138type B pancreatic cell proliferation (GO:0044342)2.57675627
139positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57488881
140extracellular structure organization (GO:0043062)2.57298304
141actomyosin structure organization (GO:0031032)2.57037596
142venous blood vessel morphogenesis (GO:0048845)2.56879543
143membrane depolarization during action potential (GO:0086010)2.56771595
144regulation of cardiac muscle cell contraction (GO:0086004)2.55930829
145striatum development (GO:0021756)2.55747582
146negative regulation of axon guidance (GO:1902668)2.55473392
147blood vessel maturation (GO:0001955)2.53933597
148regulation of voltage-gated calcium channel activity (GO:1901385)2.53918428
149heparan sulfate proteoglycan metabolic process (GO:0030201)2.53854423
150striated muscle hypertrophy (GO:0014897)2.53598308
151positive regulation of synapse assembly (GO:0051965)2.52978689
152mesodermal cell differentiation (GO:0048333)2.52889682
153regulation of cardiac muscle contraction (GO:0055117)2.52531799
154myoblast fusion (GO:0007520)2.52495686
155regulation of potassium ion transmembrane transporter activity (GO:1901016)2.52036117
156mesenchymal-epithelial cell signaling (GO:0060638)2.50496785
157regulation of cardiac muscle cell differentiation (GO:2000725)2.49798827
158dermatan sulfate biosynthetic process (GO:0030208)2.48815828
159cell migration involved in sprouting angiogenesis (GO:0002042)2.47914453
160* sprouting angiogenesis (GO:0002040)2.47339154
161smooth muscle tissue development (GO:0048745)2.45973362
162muscle tissue morphogenesis (GO:0060415)2.45677675
163negative chemotaxis (GO:0050919)2.45559891
164muscle cell fate commitment (GO:0042693)2.45215342
165heart contraction (GO:0060047)2.45068910
166heart process (GO:0003015)2.45068910
167peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43313012
168multicellular organismal macromolecule metabolic process (GO:0044259)2.42416216
169regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.42027337
170skeletal muscle tissue development (GO:0007519)2.41839956
171positive regulation of fibroblast migration (GO:0010763)2.41791718
172axon extension (GO:0048675)2.41047923
173endothelium development (GO:0003158)2.40760272
174positive regulation of astrocyte differentiation (GO:0048711)2.39434818
175negative regulation of cartilage development (GO:0061037)2.38496989
176bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38346412
177skeletal muscle fiber development (GO:0048741)2.38088416
178positive regulation of axon extension (GO:0045773)2.37774275
179positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37756545
180cellular response to vitamin D (GO:0071305)2.37103633
181cell-matrix adhesion (GO:0007160)2.34093943
182neural crest cell development (GO:0014032)2.33845941
183negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.32371742
184regulation of sarcomere organization (GO:0060297)2.32111308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.56512239
2EZH2_22144423_ChIP-Seq_EOC_Human5.42285246
3* GBX2_23144817_ChIP-Seq_PC3_Human3.14975521
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93760770
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92961915
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.80637021
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72171988
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.58702734
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56556143
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56556143
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52834097
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43952944
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35112071
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33805227
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33543024
16CJUN_26792858_Chip-Seq_BT549_Human2.32492284
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24605251
18AR_21572438_ChIP-Seq_LNCaP_Human2.20388260
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.18112555
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.11781048
21DROSHA_22980978_ChIP-Seq_HELA_Human2.11736177
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07943210
23BRD4_25478319_ChIP-Seq_HGPS_Human2.04009407
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01286789
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00744797
26* EP300_21415370_ChIP-Seq_HL-1_Mouse1.90868737
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88641768
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.86732647
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84208341
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83063974
31* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82324448
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.82001550
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.80284919
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78411355
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78411355
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75853977
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.74594841
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73963828
39TAF15_26573619_Chip-Seq_HEK293_Human1.71752836
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65442614
41* REST_18959480_ChIP-ChIP_MESCs_Mouse1.59268380
42ZNF274_21170338_ChIP-Seq_K562_Hela1.58373260
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58318292
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56858525
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55319525
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54006156
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.53706152
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.52208953
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49301459
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.41645953
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40943560
52* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39970423
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37202873
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37153490
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36275070
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34940539
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.31566003
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31057004
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.30832543
60* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29040553
61* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29040553
62* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28751139
63P300_19829295_ChIP-Seq_ESCs_Human1.27826336
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27360140
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.27335748
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27106413
67* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26924962
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26179567
69AHR_22903824_ChIP-Seq_MCF-7_Human1.25123525
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25093470
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25014855
72* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24573996
73* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24549557
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.23872821
75* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23296109
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.23238941
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.23238941
78TP63_23658742_ChIP-Seq_EP156T_Human1.22453731
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21987147
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19255035
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.18697536
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18528146
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.15434747
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15188213
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14369355
86AR_25329375_ChIP-Seq_VCAP_Human1.13356639
87* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12737509
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12371863
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11994803
90* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11558027
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11409821
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10735136
93* TP53_18474530_ChIP-ChIP_U2OS_Human1.09354454
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09181106
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08667034
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06331123
97* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06006989
98* AR_19668381_ChIP-Seq_PC3_Human1.05253905
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.03023903
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02699163
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02663765
102* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01534433
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.01210615
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.00974371
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00745968
106BCAT_22108803_ChIP-Seq_LS180_Human1.00595414
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00286860
108* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99660598
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99539801
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99109128
111* STAT3_23295773_ChIP-Seq_U87_Human0.99085173
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98643855
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.98573811
114* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98232019
115* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98091391
116* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97503466
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.97146903
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97030170
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96345744
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.96211124
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.96139899
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95754299
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.95592928
124TP53_16413492_ChIP-PET_HCT116_Human0.94797008
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93974129
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93728894
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93690428
128* KDM2B_26808549_Chip-Seq_REH_Human0.93267931
129* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93090892
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92957061
131* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92738341
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.91966449
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91287968
134* TCF4_23295773_ChIP-Seq_U87_Human0.90413782
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90399750
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.89574681
137RNF2_27304074_Chip-Seq_NSC_Mouse0.89513723
138VDR_22108803_ChIP-Seq_LS180_Human0.87059155
139* ER_23166858_ChIP-Seq_MCF-7_Human0.86734004
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86573466
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86194943
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82818876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.75660712
2MP0002837_dystrophic_cardiac_calcinosis4.36890702
3MP0000751_myopathy4.05125446
4MP0005275_abnormal_skin_tensile3.90810150
5MP0004859_abnormal_synaptic_plasticity3.77656653
6MP0003705_abnormal_hypodermis_morpholog3.38939962
7MP0003646_muscle_fatigue3.23782728
8MP0003279_aneurysm3.04761222
9MP0004215_abnormal_myocardial_fiber3.03207308
10MP0004084_abnormal_cardiac_muscle2.96692000
11MP0003880_abnormal_central_pattern2.92128373
12MP0010368_abnormal_lymphatic_system2.87460696
13MP0003635_abnormal_synaptic_transmissio2.80056280
14MP0001958_emphysema2.74710131
15MP0004036_abnormal_muscle_relaxation2.49131753
16MP0000579_abnormal_nail_morphology2.47905067
17MP0003566_abnormal_cell_adhesion2.36754804
18MP0004270_analgesia2.34318659
19MP0009745_abnormal_behavioral_response2.29709745
20MP0009046_muscle_twitch2.29590318
21MP0000749_muscle_degeneration2.25456589
22MP0002063_abnormal_learning/memory/cond2.20750604
23MP0004145_abnormal_muscle_electrophysio2.15303992
24MP0006054_spinal_hemorrhage2.11696186
25MP0005330_cardiomyopathy2.08707831
26MP0002064_seizures2.07829695
27MP0009384_cardiac_valve_regurgitation1.99355491
28MP0003137_abnormal_impulse_conducting1.99187256
29MP0002572_abnormal_emotion/affect_behav1.94682640
30MP0001968_abnormal_touch/_nociception1.92343490
31MP0003941_abnormal_skin_development1.92190834
32MP0005620_abnormal_muscle_contractility1.89382710
33MP0002972_abnormal_cardiac_muscle1.86273162
34MP0004484_altered_response_of1.85456188
35MP0002734_abnormal_mechanical_nocicepti1.85421763
36MP0002822_catalepsy1.83488776
37MP0000762_abnormal_tongue_morphology1.79081250
38MP0001879_abnormal_lymphatic_vessel1.77757337
39MP0004130_abnormal_muscle_cell1.77746718
40MP0004085_abnormal_heartbeat1.76250826
41MP0009780_abnormal_chondrocyte_physiolo1.76135203
42MP0001529_abnormal_vocalization1.75871803
43MP0004087_abnormal_muscle_fiber1.75678089
44MP0006276_abnormal_autonomic_nervous1.71976297
45MP0005423_abnormal_somatic_nervous1.71940783
46MP0002060_abnormal_skin_morphology1.69579219
47MP0005257_abnormal_intraocular_pressure1.67952541
48MP0002272_abnormal_nervous_system1.67757250
49MP0001486_abnormal_startle_reflex1.67287576
50MP0000767_abnormal_smooth_muscle1.64785654
51MP0000750_abnormal_muscle_regeneration1.64360353
52MP0008775_abnormal_heart_ventricle1.63995831
53MP0001440_abnormal_grooming_behavior1.62048373
54MP0002106_abnormal_muscle_physiology1.61083116
55MP0004233_abnormal_muscle_weight1.59556120
56MP0002736_abnormal_nociception_after1.55292722
57MP0005386_behavior/neurological_phenoty1.54270578
58MP0004924_abnormal_behavior1.54270578
59MP0001501_abnormal_sleep_pattern1.53779683
60MP0002295_abnormal_pulmonary_circulatio1.50495461
61MP0001542_abnormal_bone_strength1.49409702
62MP0005023_abnormal_wound_healing1.49020167
63MP0002909_abnormal_adrenal_gland1.46248131
64MP0005623_abnormal_meninges_morphology1.45552414
65MP0000747_muscle_weakness1.45235523
66MP0005369_muscle_phenotype1.43966832
67MP0006138_congestive_heart_failure1.42732407
68MP0004858_abnormal_nervous_system1.42562859
69MP0003122_maternal_imprinting1.42116515
70MP0000733_abnormal_muscle_development1.40313557
71MP0000013_abnormal_adipose_tissue1.40239147
72MP0002067_abnormal_sensory_capabilities1.40036204
73MP0002735_abnormal_chemical_nociception1.39567209
74MP0000759_abnormal_skeletal_muscle1.36777277
75MP0000778_abnormal_nervous_system1.36068928
76MP0001970_abnormal_pain_threshold1.33670672
77MP0002184_abnormal_innervation1.33640701
78MP0005385_cardiovascular_system_phenoty1.32955598
79MP0001544_abnormal_cardiovascular_syste1.32955598
80MP0005595_abnormal_vascular_smooth1.30272235
81MP0002896_abnormal_bone_mineralization1.27268982
82MP0002733_abnormal_thermal_nociception1.26446385
83MP0002269_muscular_atrophy1.24025993
84MP0005171_absent_coat_pigmentation1.23778498
85MP0010030_abnormal_orbit_morphology1.23461973
86MP0000467_abnormal_esophagus_morphology1.22727633
87MP0002557_abnormal_social/conspecific_i1.22548457
88MP0009250_abnormal_appendicular_skeleto1.19750679
89MP0004134_abnormal_chest_morphology1.17343607
90MP0002332_abnormal_exercise_endurance1.16889297
91MP0003329_amyloid_beta_deposits1.13255908
92MP0003091_abnormal_cell_migration1.12696180
93MP0005508_abnormal_skeleton_morphology1.12094813
94MP0008569_lethality_at_weaning1.11401137
95MP0003045_fibrosis1.11310418
96MP0001905_abnormal_dopamine_level1.10460271
97MP0009053_abnormal_anal_canal1.07508479
98MP0005165_increased_susceptibility_to1.05490816
99MP0001849_ear_inflammation1.04868235
100MP0004142_abnormal_muscle_tone1.04456800
101MP0002108_abnormal_muscle_morphology1.04214217
102MP0005645_abnormal_hypothalamus_physiol1.03300830
103MP0004811_abnormal_neuron_physiology1.02628568
104MP0010630_abnormal_cardiac_muscle1.00323997
105MP0005409_darkened_coat_color0.99797843
106MP0005646_abnormal_pituitary_gland0.99646034
107MP0002066_abnormal_motor_capabilities/c0.97346914
108MP0000534_abnormal_ureter_morphology0.97019325
109MP0002234_abnormal_pharynx_morphology0.94181709
110MP0000955_abnormal_spinal_cord0.94130990
111MP0000538_abnormal_urinary_bladder0.93484584
112MP0002168_other_aberrant_phenotype0.93059022
113MP0004272_abnormal_basement_membrane0.90772873
114MP0002282_abnormal_trachea_morphology0.89573598
115MP0002882_abnormal_neuron_morphology0.89400460
116MP0001984_abnormal_olfaction0.87587797
117MP0003755_abnormal_palate_morphology0.86446975
118MP0001299_abnormal_eye_distance/0.86142931
119MP0004510_myositis0.81361135
120MP0010386_abnormal_urinary_bladder0.81170674
121MP0003828_pulmonary_edema0.80071962
122MP0003879_abnormal_hair_cell0.79582495
123MP0001188_hyperpigmentation0.79492525
124MP0000569_abnormal_digit_pigmentation0.79224906
125MP0002127_abnormal_cardiovascular_syste0.78727378
126MP0005388_respiratory_system_phenotype0.77575944
127MP0002133_abnormal_respiratory_system0.77575944
128MP0002128_abnormal_blood_circulation0.73463057
129MP0000003_abnormal_adipose_tissue0.70439946
130MP0005360_urolithiasis0.68297525
131MP0005535_abnormal_body_temperature0.67447035
132MP0000230_abnormal_systemic_arterial0.67261431
133MP0010771_integument_phenotype0.66781243
134MP0008874_decreased_physiological_sensi0.65865196
135MP0001502_abnormal_circadian_rhythm0.65816939
136MP0002152_abnormal_brain_morphology0.65683177
137MP0003221_abnormal_cardiomyocyte_apopto0.65078179
138MP0005503_abnormal_tendon_morphology0.64158192
139MP0003787_abnormal_imprinting0.62262657
140MP0000163_abnormal_cartilage_morphology0.62098431
141MP0001243_abnormal_dermal_layer0.61578406
142MP0002090_abnormal_vision0.60651527
143MP0003633_abnormal_nervous_system0.60496215
144MP0005197_abnormal_uvea_morphology0.60273521
145MP0003634_abnormal_glial_cell0.59532402
146MP0003385_abnormal_body_wall0.59304845
147MP0001915_intracranial_hemorrhage0.57871981
148MP0008961_abnormal_basal_metabolism0.57704662
149MP0003950_abnormal_plasma_membrane0.56775226
150MP0001943_abnormal_respiration0.56411022
151* MP0001614_abnormal_blood_vessel0.56284121
152MP0005187_abnormal_penis_morphology0.55611645
153MP0005164_abnormal_response_to0.55534634
154MP0003935_abnormal_craniofacial_develop0.54417189
155MP0002932_abnormal_joint_morphology0.54268535
156MP0002177_abnormal_outer_ear0.53980698
157MP0000462_abnormal_digestive_system0.53890952
158MP0003283_abnormal_digestive_organ0.53561215

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)5.95121519
2Premature rupture of membranes (HP:0001788)5.83932613
3Sudden death (HP:0001699)5.44261108
4Protrusio acetabuli (HP:0003179)5.33891327
5Exercise-induced myalgia (HP:0003738)4.67473689
6Popliteal pterygium (HP:0009756)4.61688247
7Aortic dissection (HP:0002647)4.60252541
8Calf muscle hypertrophy (HP:0008981)4.54921029
9Abnormality of the calf musculature (HP:0001430)4.37185282
10Muscle hypertrophy of the lower extremities (HP:0008968)4.36897760
11Arterial tortuosity (HP:0005116)4.15594104
12Vascular tortuosity (HP:0004948)4.11695999
13Focal motor seizures (HP:0011153)4.02350903
14Atrial fibrillation (HP:0005110)4.01134501
15Primary atrial arrhythmia (HP:0001692)3.87980622
16Muscle fiber splitting (HP:0003555)3.86573231
17Aortic aneurysm (HP:0004942)3.85366134
18Myokymia (HP:0002411)3.78796712
19Supraventricular tachycardia (HP:0004755)3.69510381
20Fatigable weakness (HP:0003473)3.69430349
21Abnormality of the neuromuscular junction (HP:0003398)3.69430349
22Follicular hyperkeratosis (HP:0007502)3.68653672
23Supraventricular arrhythmia (HP:0005115)3.64979487
24Fragile skin (HP:0001030)3.64831041
25Ventricular tachycardia (HP:0004756)3.64708367
26Amniotic constriction ring (HP:0009775)3.64130521
27Abnormality of placental membranes (HP:0011409)3.64130521
28Hyporeflexia of lower limbs (HP:0002600)3.61197451
29Exercise-induced muscle cramps (HP:0003710)3.60021707
30Milia (HP:0001056)3.59955574
31Pterygium (HP:0001059)3.56659308
32Prolonged QT interval (HP:0001657)3.45543189
33Soft skin (HP:0000977)3.44869219
34EMG: myopathic abnormalities (HP:0003458)3.42252561
35Syncope (HP:0001279)3.34575961
36Fragile nails (HP:0001808)3.33865882
37Myotonia (HP:0002486)3.28106730
38Round ear (HP:0100830)3.19786363
39Onycholysis (HP:0001806)3.18308562
40Focal seizures (HP:0007359)3.14093287
41Visual hallucinations (HP:0002367)3.13671973
42Right ventricular cardiomyopathy (HP:0011663)3.11191668
43Difficulty running (HP:0009046)3.11164382
44Bladder diverticulum (HP:0000015)3.00145416
45Pheochromocytoma (HP:0002666)2.98238523
46Ventricular fibrillation (HP:0001663)2.95044457
47Increased variability in muscle fiber diameter (HP:0003557)2.94465918
48Type 2 muscle fiber atrophy (HP:0003554)2.86024869
49Bundle branch block (HP:0011710)2.83738846
50Limb dystonia (HP:0002451)2.80376761
51Abnormal EKG (HP:0003115)2.80050240
52Type 1 muscle fiber predominance (HP:0003803)2.79797563
53Spinal rigidity (HP:0003306)2.79162858
54Weak cry (HP:0001612)2.76945044
55Lipoatrophy (HP:0100578)2.74682088
56Muscle fiber inclusion bodies (HP:0100299)2.74582806
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73854350
58Fetal akinesia sequence (HP:0001989)2.73280198
59Cerebral aneurysm (HP:0004944)2.70096707
60Lower limb amyotrophy (HP:0007210)2.69286385
61Abnormality of skeletal muscle fiber size (HP:0012084)2.68845037
62Ventricular arrhythmia (HP:0004308)2.67763837
63Increased connective tissue (HP:0009025)2.66185058
64Abnormality of dentin (HP:0010299)2.61531803
65Atonic seizures (HP:0010819)2.59639500
66Neuroendocrine neoplasm (HP:0100634)2.58893384
67Ankle contracture (HP:0006466)2.58644743
68Wrist flexion contracture (HP:0001239)2.55748220
69Neonatal short-limb short stature (HP:0008921)2.55162981
70Genu recurvatum (HP:0002816)2.54364085
71Slender build (HP:0001533)2.51516326
72Shallow orbits (HP:0000586)2.50597963
73Spondylolisthesis (HP:0003302)2.48280029
74Delayed gross motor development (HP:0002194)2.47688431
75Impaired vibration sensation in the lower limbs (HP:0002166)2.47502038
76Progressive cerebellar ataxia (HP:0002073)2.46704003
77Aplasia of the musculature (HP:0100854)2.46304777
78Plantar hyperkeratosis (HP:0007556)2.45602892
79Wormian bones (HP:0002645)2.45097787
80Muscle fiber atrophy (HP:0100295)2.43457406
81Aortic regurgitation (HP:0001659)2.42217240
82Subaortic stenosis (HP:0001682)2.41273504
83Abnormality of the left ventricular outflow tract (HP:0011103)2.41273504
84Overgrowth (HP:0001548)2.40858843
85Palpitations (HP:0001962)2.40280447
86Acute necrotizing encephalopathy (HP:0006965)2.39578835
87Broad-based gait (HP:0002136)2.38872135
88Myoglobinuria (HP:0002913)2.38012976
89Difficulty climbing stairs (HP:0003551)2.37709840
90Abnormal mitochondria in muscle tissue (HP:0008316)2.37299849
91Epileptic encephalopathy (HP:0200134)2.35469549
92Broad metatarsal (HP:0001783)2.35329546
93Cervical subluxation (HP:0003308)2.34973213
94Malignant hyperthermia (HP:0002047)2.34434183
95Nemaline bodies (HP:0003798)2.33960148
96Generalized tonic-clonic seizures (HP:0002069)2.33635235
97Distal lower limb amyotrophy (HP:0008944)2.30471495
98Polyphagia (HP:0002591)2.25721607
99Limited hip movement (HP:0008800)2.25720917
100Absence seizures (HP:0002121)2.24057358
101Left ventricular hypertrophy (HP:0001712)2.22223548
102Mesomelia (HP:0003027)2.19421135
103Heart block (HP:0012722)2.18659944
104Limb-girdle muscle atrophy (HP:0003797)2.17615470
105Dilated cardiomyopathy (HP:0001644)2.16549193
106Abnormal atrioventricular conduction (HP:0005150)2.16240468
107Distal arthrogryposis (HP:0005684)2.15774321
108Ulnar deviation of the wrist (HP:0003049)2.13570520
109Ankle clonus (HP:0011448)2.13366000
110Anxiety (HP:0000739)2.13062797
111Progressive macrocephaly (HP:0004481)2.11647447
112Mitral valve prolapse (HP:0001634)2.10357986
113Progressive inability to walk (HP:0002505)2.09255394
114Febrile seizures (HP:0002373)2.08580684
115Blue sclerae (HP:0000592)2.04637260
116Hypoplasia of the iris (HP:0007676)2.04601702
117Atrioventricular block (HP:0001678)2.03109364
118Alopecia of scalp (HP:0002293)2.02748834
119Gowers sign (HP:0003391)2.02689770
120Oligomenorrhea (HP:0000876)2.00370099
121Neck muscle weakness (HP:0000467)2.00119484
122Dilatation of the ascending aorta (HP:0005111)1.99675113
123Thin ribs (HP:0000883)1.98387956
124Hyperextensible skin (HP:0000974)1.98033166
125Thick nail (HP:0001805)1.97976449
126Muscle stiffness (HP:0003552)1.97790623
127Dysmetric saccades (HP:0000641)1.97058733
128Failure to thrive in infancy (HP:0001531)1.95813851
129Asymmetric septal hypertrophy (HP:0001670)1.95127459
130Abnormal eating behavior (HP:0100738)1.93871768
131Hypoventilation (HP:0002791)1.93828890
132Dysdiadochokinesis (HP:0002075)1.93577216
133Depression (HP:0000716)1.93302749
134Hip contracture (HP:0003273)1.93068922
135Bradycardia (HP:0001662)1.92619348
136Hepatocellular necrosis (HP:0001404)1.91726151
137Mitochondrial inheritance (HP:0001427)1.90771190
138Dialeptic seizures (HP:0011146)1.88846812
139Rapidly progressive (HP:0003678)1.88197402
140Akinesia (HP:0002304)1.87510442
141Peritonitis (HP:0002586)1.87328738
142Broad ribs (HP:0000885)1.85073268
143Cardiovascular calcification (HP:0011915)1.83823474
144Mutism (HP:0002300)1.83587221
145Abnormality of nail color (HP:0100643)1.83465394
146Infantile muscular hypotonia (HP:0008947)1.82577929
147Absent phalangeal crease (HP:0006109)1.82070903
148Rimmed vacuoles (HP:0003805)1.81769002
149Urinary urgency (HP:0000012)1.80875233
150Muscular dystrophy (HP:0003560)1.80384628
151Neoplasm of the peripheral nervous system (HP:0100007)1.79272836
152Mildly elevated creatine phosphokinase (HP:0008180)1.79199342
153Mitral stenosis (HP:0001718)1.78835799
154Natal tooth (HP:0000695)1.76801707
155Hyperventilation (HP:0002883)1.76296076
156Easy fatigability (HP:0003388)1.75600497
157Keratoconus (HP:0000563)1.75308197
158Increased corneal curvature (HP:0100692)1.75308197
159Poor eye contact (HP:0000817)1.75232102
160Scapular winging (HP:0003691)1.74886299
161Urinary bladder sphincter dysfunction (HP:0002839)1.74106378
162Acute encephalopathy (HP:0006846)1.73750028
163Bowel diverticulosis (HP:0005222)1.73060045
164Distal lower limb muscle weakness (HP:0009053)1.72450496
165Shoulder girdle muscle weakness (HP:0003547)1.71838405
166Impaired social interactions (HP:0000735)1.71383887
167Abnormal social behavior (HP:0012433)1.71383887
168Foot dorsiflexor weakness (HP:0009027)1.71290002
169Deformed tarsal bones (HP:0008119)1.70890370
170Nail dystrophy (HP:0008404)1.70548004
171Aortic valve stenosis (HP:0001650)1.70207298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.67824901
2PHKG13.20814393
3PHKG23.20814393
4NTRK32.72092847
5MAP3K42.60967799
6MAP3K92.56907742
7MAP3K122.52751881
8TTN2.49095148
9TGFBR22.37927901
10OBSCN2.28893684
11NTRK22.10246675
12DDR22.06308733
13CASK2.05377572
14PDK32.01257500
15PDK42.01257500
16MAP2K72.00654416
17MYLK1.98232014
18LMTK21.97906327
19EPHA41.94082502
20PIK3CG1.92281461
21PTK21.92168649
22MINK11.83646767
23MOS1.81342750
24MAP2K41.71497596
25PAK31.59007830
26NEK91.49448474
27MAP3K31.48552423
28DMPK1.46032801
29MUSK1.45909388
30PAK21.45527642
31PAK61.44556730
32MET1.44453317
33TRPM71.44319295
34PDK21.38479832
35LATS21.37342906
36DAPK21.31625866
37MAPK131.31134655
38LATS11.29427164
39TGFBR11.29143126
40PLK21.27131177
41CAMK2A1.25133861
42TESK11.24872336
43CDK51.17231825
44PAK41.15778638
45NEK11.14575136
46FER1.13841168
47PIK3CA1.11236164
48GRK51.09526980
49MAPKAPK31.09105679
50KSR11.03890436
51GRK71.02757379
52NTRK10.98898674
53CAMK2D0.98628452
54TIE10.97027727
55KSR20.95084850
56FLT30.94126573
57NME10.94029962
58FRK0.93815547
59ROCK10.93480982
60PRKD20.90774535
61EPHB20.89761557
62LIMK10.89237607
63STK240.89039304
64TRIM280.88476303
65TNIK0.87824865
66PKN10.87219149
67STK380.84811879
68UHMK10.84565996
69PRPF4B0.84323619
70MAPK120.83670959
71PRKCE0.82820466
72PIM20.81250368
73TYRO30.80334232
74PDGFRB0.79142205
75PRKCG0.78565255
76CDK190.77397756
77PTK2B0.76559563
78TRIB30.76285221
79CAMKK10.76201920
80ROCK20.74993521
81PRKCH0.73169509
82PRKD30.72405601
83CSNK1G20.72140037
84CAMK10.70590111
85CDC42BPA0.70459190
86MARK20.69278165
87ILK0.68435947
88ERBB30.68432890
89SIK20.67272310
90CDK140.66968604
91CAMK2B0.65945278
92PINK10.65259046
93RET0.64722719
94CDK180.64504331
95DAPK10.64498335
96STK110.64076018
97BCR0.63590503
98DAPK30.63427607
99CDK150.62581101
100CAMK2G0.59946094
101FES0.59692050
102SGK10.59007188
103PRKD10.58650450
104SGK4940.58267520
105SGK2230.58267520
106GSK3A0.57453204
107TAOK10.56465506
108MAP2K10.56305019
109ARAF0.55896770
110ABL20.55475819
111STK38L0.53422540
112RIPK10.52585868
113CDK11A0.51645177
114PKN20.50169246
115CAMK40.50160517
116RPS6KA20.50155258
117EIF2AK30.49099502
118MAPKAPK50.48837446
119PRKG20.48114462
120SGK20.47838650
121MAPK70.46560300
122DYRK20.46288184
123ADRBK10.45734772
124SIK30.45701861
125PRKACA0.44183557
126PDGFRA0.43957290
127DYRK1A0.43683691
128PNCK0.43155520
129MAP3K70.42186014
130MAPK40.38235945
131ERBB40.37811262
132AKT30.36388871
133BMPR1B0.35152394
134WNK30.33066722
135WNK10.32082389
136STK390.31735208
137ABL10.31310984
138RAF10.29778057
139CCNB10.29116699
140INSR0.29007129

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042602.67462003
2Nicotine addiction_Homo sapiens_hsa050332.60282846
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56901968
4Dilated cardiomyopathy_Homo sapiens_hsa054142.44945832
5Synaptic vesicle cycle_Homo sapiens_hsa047212.44803368
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.26491292
7Oxidative phosphorylation_Homo sapiens_hsa001902.21242079
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.11347257
9GABAergic synapse_Homo sapiens_hsa047272.08578822
10Parkinsons disease_Homo sapiens_hsa050122.05892322
11Circadian entrainment_Homo sapiens_hsa047132.02877655
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00096166
13Olfactory transduction_Homo sapiens_hsa047401.95924434
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91147222
15Morphine addiction_Homo sapiens_hsa050321.84930421
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83723506
17Amphetamine addiction_Homo sapiens_hsa050311.77232748
18Alzheimers disease_Homo sapiens_hsa050101.71207790
19Glutamatergic synapse_Homo sapiens_hsa047241.69007534
20Proteoglycans in cancer_Homo sapiens_hsa052051.66321349
21Dopaminergic synapse_Homo sapiens_hsa047281.65217961
22Long-term potentiation_Homo sapiens_hsa047201.63946654
23Cocaine addiction_Homo sapiens_hsa050301.61594105
24Protein digestion and absorption_Homo sapiens_hsa049741.58849605
25Renin secretion_Homo sapiens_hsa049241.57499723
26Oxytocin signaling pathway_Homo sapiens_hsa049211.53818401
27Collecting duct acid secretion_Homo sapiens_hsa049661.53474685
28Cholinergic synapse_Homo sapiens_hsa047251.52333448
29Salivary secretion_Homo sapiens_hsa049701.51857716
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51618206
31Calcium signaling pathway_Homo sapiens_hsa040201.50738605
32Insulin secretion_Homo sapiens_hsa049111.48882401
33Gastric acid secretion_Homo sapiens_hsa049711.47304270
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45167386
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43301831
36Taste transduction_Homo sapiens_hsa047421.42190805
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40785303
38Serotonergic synapse_Homo sapiens_hsa047261.39516748
39Small cell lung cancer_Homo sapiens_hsa052221.38086833
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37286761
41Adherens junction_Homo sapiens_hsa045201.32662302
42Hippo signaling pathway_Homo sapiens_hsa043901.31290405
43Gap junction_Homo sapiens_hsa045401.27018907
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26166824
45Long-term depression_Homo sapiens_hsa047301.24740652
46Huntingtons disease_Homo sapiens_hsa050161.22759774
47Axon guidance_Homo sapiens_hsa043601.20348305
48TGF-beta signaling pathway_Homo sapiens_hsa043501.16499544
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14770986
50GnRH signaling pathway_Homo sapiens_hsa049121.13465070
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11625235
52Circadian rhythm_Homo sapiens_hsa047101.11299741
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09734957
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06118970
55cAMP signaling pathway_Homo sapiens_hsa040241.04877012
56Vibrio cholerae infection_Homo sapiens_hsa051101.02862068
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01973799
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.00526417
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98566082
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94958439
61Estrogen signaling pathway_Homo sapiens_hsa049150.93887570
62Hedgehog signaling pathway_Homo sapiens_hsa043400.92994913
63Melanogenesis_Homo sapiens_hsa049160.92203446
64Type II diabetes mellitus_Homo sapiens_hsa049300.89140199
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87441521
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86780216
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83446318
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82956793
69Butanoate metabolism_Homo sapiens_hsa006500.82572445
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78934636
71Pathways in cancer_Homo sapiens_hsa052000.78126719
72Glucagon signaling pathway_Homo sapiens_hsa049220.77347773
73Basal cell carcinoma_Homo sapiens_hsa052170.76797365
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.76107222
75Prion diseases_Homo sapiens_hsa050200.74155727
76MicroRNAs in cancer_Homo sapiens_hsa052060.73732851
77ErbB signaling pathway_Homo sapiens_hsa040120.72702887
78Glioma_Homo sapiens_hsa052140.72683330
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71738440
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70682955
81Viral myocarditis_Homo sapiens_hsa054160.70306196
82Phototransduction_Homo sapiens_hsa047440.68166815
83Propanoate metabolism_Homo sapiens_hsa006400.67698999
84Insulin signaling pathway_Homo sapiens_hsa049100.67595283
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67007530
86Tight junction_Homo sapiens_hsa045300.66822807
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65921613
88Bladder cancer_Homo sapiens_hsa052190.65056814
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64011134
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63372242
91Dorso-ventral axis formation_Homo sapiens_hsa043200.63217469
92Renal cell carcinoma_Homo sapiens_hsa052110.61192615
93Focal adhesion_Homo sapiens_hsa045100.60719579
94MAPK signaling pathway_Homo sapiens_hsa040100.60246891
95Pyruvate metabolism_Homo sapiens_hsa006200.59700505
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54771693
97Ras signaling pathway_Homo sapiens_hsa040140.52464950
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.51979065
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50773036
100Ovarian steroidogenesis_Homo sapiens_hsa049130.49300696
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49204519
102Rap1 signaling pathway_Homo sapiens_hsa040150.49106178
103ECM-receptor interaction_Homo sapiens_hsa045120.48994654
104Fatty acid metabolism_Homo sapiens_hsa012120.47863328
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47859759
106Platelet activation_Homo sapiens_hsa046110.47833524
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47347789
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.47182384
109Carbon metabolism_Homo sapiens_hsa012000.47003920
110p53 signaling pathway_Homo sapiens_hsa041150.45588834
111Endocytosis_Homo sapiens_hsa041440.45561282
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.45246179
113Pancreatic secretion_Homo sapiens_hsa049720.44255844
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.44198158
115Thyroid hormone synthesis_Homo sapiens_hsa049180.42591056
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42090799
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39386757
118AMPK signaling pathway_Homo sapiens_hsa041520.38933568
119Endometrial cancer_Homo sapiens_hsa052130.38119661
120Mineral absorption_Homo sapiens_hsa049780.37438183
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36317465
122VEGF signaling pathway_Homo sapiens_hsa043700.35778643
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.35408151
124Amoebiasis_Homo sapiens_hsa051460.35313784
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35213763
126Protein export_Homo sapiens_hsa030600.34788266
127Malaria_Homo sapiens_hsa051440.34458695
128Wnt signaling pathway_Homo sapiens_hsa043100.34268320
129Melanoma_Homo sapiens_hsa052180.33422686
130Oocyte meiosis_Homo sapiens_hsa041140.33110931
131Insulin resistance_Homo sapiens_hsa049310.32167760
132Rheumatoid arthritis_Homo sapiens_hsa053230.31770825
133Choline metabolism in cancer_Homo sapiens_hsa052310.31537208
134Fatty acid biosynthesis_Homo sapiens_hsa000610.30727708
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.30002464

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