CDH16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.30606980
2aminoglycoside antibiotic metabolic process (GO:0030647)9.13930491
3drug transmembrane transport (GO:0006855)9.07226772
4lysine metabolic process (GO:0006553)8.24546431
5lysine catabolic process (GO:0006554)8.24546431
6drug transport (GO:0015893)7.76125908
7organic cation transport (GO:0015695)7.64627927
8response to mercury ion (GO:0046689)7.59245158
9phosphate ion transport (GO:0006817)7.55597366
10excretion (GO:0007588)7.52459425
11mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.84317693
12renal absorption (GO:0070293)6.81466787
13metanephric tubule development (GO:0072170)6.74979237
14metanephric nephron tubule development (GO:0072234)6.74979237
15regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.63864923
16cardiovascular system development (GO:0072358)6.40757168
17negative regulation of metanephros development (GO:0072217)6.37539893
18metanephric nephron epithelium development (GO:0072243)6.35890404
19phosphate ion transmembrane transport (GO:0035435)6.30738997
20quaternary ammonium group transport (GO:0015697)6.26107320
21glyoxylate metabolic process (GO:0046487)6.02372257
22cysteine metabolic process (GO:0006534)5.90186392
23metanephric epithelium development (GO:0072207)5.87672609
24polyol transport (GO:0015791)5.71350180
25negative regulation of cholesterol transport (GO:0032375)5.70313984
26negative regulation of sterol transport (GO:0032372)5.70313984
27regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.70310387
28tricarboxylic acid metabolic process (GO:0072350)5.68265497
29response to water (GO:0009415)5.56614672
30aspartate family amino acid catabolic process (GO:0009068)5.56523404
31vitamin D metabolic process (GO:0042359)5.38760240
32pattern specification involved in kidney development (GO:0061004)5.30763027
33drug catabolic process (GO:0042737)5.24910102
34nephron tubule development (GO:0072080)5.07834528
35nonribosomal peptide biosynthetic process (GO:0019184)5.06629708
36negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.06521713
37short-chain fatty acid metabolic process (GO:0046459)5.04459673
38response to thyroid hormone (GO:0097066)4.97091211
39exogenous drug catabolic process (GO:0042738)4.95607710
40positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.91753976
41branched-chain amino acid metabolic process (GO:0009081)4.89117309
42positive regulation of catenin import into nucleus (GO:0035413)4.83105099
43toxin transport (GO:1901998)4.76755882
44valine metabolic process (GO:0006573)4.71560819
45amino-acid betaine transport (GO:0015838)4.69010650
46carnitine transport (GO:0015879)4.69010650
472-oxoglutarate metabolic process (GO:0006103)4.66211357
48phosphate ion homeostasis (GO:0055062)4.62981034
49trivalent inorganic anion homeostasis (GO:0072506)4.62981034
50homocysteine metabolic process (GO:0050667)4.62353416
51glutathione biosynthetic process (GO:0006750)4.55643890
52renal tubule development (GO:0061326)4.50048308
53positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.43851100
54modified amino acid transport (GO:0072337)4.43053763
55response to parathyroid hormone (GO:0071107)4.42697847
56tryptophan catabolic process (GO:0006569)4.37707048
57indole-containing compound catabolic process (GO:0042436)4.37707048
58indolalkylamine catabolic process (GO:0046218)4.37707048
59hyperosmotic response (GO:0006972)4.36855315
60aromatic amino acid family catabolic process (GO:0009074)4.35712590
61activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.34413735
62thyroid hormone generation (GO:0006590)4.31598896
63L-phenylalanine metabolic process (GO:0006558)4.30592470
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.30592470
65nephron epithelium development (GO:0072009)4.25093534
66cellular modified amino acid catabolic process (GO:0042219)4.22837448
67collecting duct development (GO:0072044)4.21065657
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.19958823
69L-phenylalanine catabolic process (GO:0006559)4.19958823
70amino-acid betaine metabolic process (GO:0006577)4.17757745
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16024424
72glycoside metabolic process (GO:0016137)4.13413735
73fatty acid beta-oxidation (GO:0006635)4.11985033
74branched-chain amino acid catabolic process (GO:0009083)4.11622029
75tryptophan metabolic process (GO:0006568)4.11616468
76proline metabolic process (GO:0006560)4.10966432
77cell differentiation involved in metanephros development (GO:0072202)4.06290787
78response to copper ion (GO:0046688)4.03599897
79gamma-aminobutyric acid transport (GO:0015812)3.98811039
80serine family amino acid catabolic process (GO:0009071)3.96986987
81inositol metabolic process (GO:0006020)3.96519627
82response to magnesium ion (GO:0032026)3.96426630
83serine family amino acid metabolic process (GO:0009069)3.95356069
84regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.95224307
85cellular ketone body metabolic process (GO:0046950)3.93422533
86mesonephros development (GO:0001823)3.93241201
87urogenital system development (GO:0001655)3.89587423
88peptide catabolic process (GO:0043171)3.88282397
89acetyl-CoA metabolic process (GO:0006084)3.87671795
90NADH metabolic process (GO:0006734)3.85654016
91regulation of mesenchymal cell apoptotic process (GO:2001053)3.83920319
92fructose metabolic process (GO:0006000)3.83628875
93fatty acid oxidation (GO:0019395)3.81467214
94carnitine metabolic process (GO:0009437)3.80232769
95response to vitamin A (GO:0033189)3.76663635
96glutamate metabolic process (GO:0006536)3.74892466
97lipid oxidation (GO:0034440)3.74679126
98renal system process (GO:0003014)3.72576894
99regulation of stem cell maintenance (GO:2000036)3.68242766
100bone remodeling (GO:0046849)3.67348328
101kynurenine metabolic process (GO:0070189)3.66952550
102peptide biosynthetic process (GO:0043043)3.62095004
103flavonoid metabolic process (GO:0009812)3.55129369
104mammary gland alveolus development (GO:0060749)3.54356626
105nephron tubule morphogenesis (GO:0072078)3.54315798
106nephron epithelium morphogenesis (GO:0072088)3.54315798
107cell volume homeostasis (GO:0006884)3.54161769
108positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.53010061
109actin filament depolymerization (GO:0030042)3.52031928
110regulation of protein localization to cell surface (GO:2000008)3.51815739
111beta-amyloid metabolic process (GO:0050435)3.50456881
112sodium-independent organic anion transport (GO:0043252)3.50419947
113cellular response to vitamin D (GO:0071305)3.49221887
114regulation of apoptotic process involved in morphogenesis (GO:1902337)3.47668400
115response to lead ion (GO:0010288)3.47466122
116response to growth hormone (GO:0060416)3.47451519
117response to phenylpropanoid (GO:0080184)3.45355947
118negative regulation of kidney development (GO:0090185)3.44475068
119tricarboxylic acid cycle (GO:0006099)3.44288936
120sulfur compound transport (GO:0072348)3.44215146
121positive regulation of cellular amine metabolic process (GO:0033240)3.44047308
122regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.43376896
123vitamin transport (GO:0051180)3.40290394
124ERK1 and ERK2 cascade (GO:0070371)3.39758705
125cellular response to ammonium ion (GO:0071242)3.39460313
126regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.38248311
127cellular amino acid catabolic process (GO:0009063)3.37743457
128ketone body metabolic process (GO:1902224)3.36959812
129thyroid hormone metabolic process (GO:0042403)3.35892553
130fatty acid catabolic process (GO:0009062)3.35429190
131positive regulation of metanephros development (GO:0072216)3.33469137
132sodium ion transport (GO:0006814)3.32006608
133surfactant homeostasis (GO:0043129)3.28842074
134positive regulation of hormone metabolic process (GO:0032352)3.28175010
135glomerular visceral epithelial cell development (GO:0072015)3.27574593
136hyperosmotic salinity response (GO:0042538)3.26526506
137alpha-amino acid catabolic process (GO:1901606)3.25750685
138mesenchymal to epithelial transition (GO:0060231)3.23509036
139biotin metabolic process (GO:0006768)3.21074654
140oxaloacetate metabolic process (GO:0006107)3.20081247
141glutathione metabolic process (GO:0006749)3.20054175
142glutathione derivative metabolic process (GO:1901685)3.18983967
143glutathione derivative biosynthetic process (GO:1901687)3.18983967
144nephron tubule formation (GO:0072079)3.18980914
145aromatic amino acid family metabolic process (GO:0009072)3.18802257
146sulfur amino acid catabolic process (GO:0000098)3.17807130
147cellular hyperosmotic response (GO:0071474)3.16043808
148specification of organ identity (GO:0010092)3.15997949
149cellular glucuronidation (GO:0052695)3.11233201
150positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.09032312
151mesenchymal cell differentiation involved in renal system development (GO:2001012)3.07921255
152mesenchymal cell differentiation involved in kidney development (GO:0072161)3.07921255
153response to salt stress (GO:0009651)3.07512074
154glycine metabolic process (GO:0006544)3.03196304
155sulfate transmembrane transport (GO:1902358)3.02938353
156positive regulation of glomerulus development (GO:0090193)2.99759220
157negative regulation of lipid transport (GO:0032369)2.99291031
158glucuronate metabolic process (GO:0019585)2.96899970
159uronic acid metabolic process (GO:0006063)2.96899970
160positive regulation of mesonephros development (GO:0061213)2.91529206
161metanephric mesenchyme development (GO:0072075)2.90993143
162L-methionine biosynthetic process (GO:0071265)2.89307071
163amino acid salvage (GO:0043102)2.89307071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.51588354
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.60642838
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30759054
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.90649248
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.87379308
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.47984212
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96936632
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.91321091
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.88246207
10CLOCK_20551151_ChIP-Seq_293T_Human2.78632815
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76987900
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76249207
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70470937
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.56395240
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.48881444
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47961946
17AR_21909140_ChIP-Seq_LNCAP_Human2.21727377
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07146626
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.06101080
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91739421
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77747376
22GATA4_25053715_ChIP-Seq_YYC3_Human1.75796690
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74458354
24DROSHA_22980978_ChIP-Seq_HELA_Human1.72655316
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72605099
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72009281
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69960263
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.68737064
29VDR_22108803_ChIP-Seq_LS180_Human1.62052390
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61027259
31RACK7_27058665_Chip-Seq_MCF-7_Human1.60250824
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.52945429
33LXR_22292898_ChIP-Seq_THP-1_Human1.51290307
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47201330
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46752070
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.40481415
37GATA6_25053715_ChIP-Seq_YYC3_Human1.38083976
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37500646
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.37223364
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35012474
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.34205365
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29733526
43EGR1_19032775_ChIP-ChIP_M12_Human1.28675719
44SOX2_20726797_ChIP-Seq_SW620_Human1.28377313
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28224874
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28189905
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27412981
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26484758
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26086703
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26026768
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25018210
52* TBX20_22328084_ChIP-Seq_HEART_Mouse1.21597534
53* TBX20_22080862_ChIP-Seq_HEART_Mouse1.21597534
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20825434
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.20798801
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20763841
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20552478
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19806756
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19577690
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17074890
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16617176
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.15685051
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15563674
64RXR_22108803_ChIP-Seq_LS180_Human1.15330389
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14798083
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14798083
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13997875
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.12951510
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10298338
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08446657
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08247752
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07989994
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07699423
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07674195
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07221775
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06733381
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06700797
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.06023674
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05922670
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05505364
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.03320348
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.02596524
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02001195
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99985187
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99972316
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.99061662
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.99045138
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98686271
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98581245
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98552924
91P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98506590
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98127436
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97221437
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.96260711
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95836385
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94714584
97EZH2_27304074_Chip-Seq_ESCs_Mouse0.93398530
98BP1_19119308_ChIP-ChIP_Hs578T_Human0.92172869
99ATF3_27146783_Chip-Seq_COLON_Human0.92021947
100KLF4_18555785_Chip-Seq_ESCs_Mouse0.90809440
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90742904
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90566140
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90561660
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89841826
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89263638
106CTCF_27219007_Chip-Seq_Bcells_Human0.88286417
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88034864
108CBP_21632823_ChIP-Seq_H3396_Human0.87951926
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.87795631
110VDR_24787735_ChIP-Seq_THP-1_Human0.87736405
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87696637
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87492204
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87161710
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87018887
115NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86884130
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86866442
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86295180
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85554536
119TP63_23658742_ChIP-Seq_EP156T_Human0.85544701
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85441842
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84403223
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.84328845
123CJUN_26792858_Chip-Seq_BT549_Human0.82835624
124CREB1_26743006_Chip-Seq_LNCaP_Human0.82675360
125* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82497622
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.82485308
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81355277
128KDM2B_26808549_Chip-Seq_K562_Human0.81140600
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80820033
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.80309022
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80277400
132AHR_22903824_ChIP-Seq_MCF-7_Human0.79187375
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.78843532
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77047270
135GATA2_19941826_ChIP-Seq_K562_Human0.76635129
136SMC4_20622854_ChIP-Seq_HELA_Human0.76383446
137* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.76153582
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75690816
139P68_20966046_ChIP-Seq_HELA_Human0.75551175
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74600550
141RAC3_21632823_ChIP-Seq_H3396_Human0.74319339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.87976116
2MP0005360_urolithiasis6.61650950
3MP0003195_calcinosis5.42013648
4MP0005332_abnormal_amino_acid4.55607591
5MP0004019_abnormal_vitamin_homeostasis4.40549423
6MP0009643_abnormal_urine_homeostasis4.10787459
7MP0001756_abnormal_urination4.05180434
8MP0001765_abnormal_ion_homeostasis3.92555700
9MP0002138_abnormal_hepatobiliary_system3.90520989
10MP0002139_abnormal_hepatobiliary_system3.84567039
11MP0002136_abnormal_kidney_physiology3.15852620
12MP0005636_abnormal_mineral_homeostasis3.14397708
13MP0003878_abnormal_ear_physiology2.67376471
14MP0005377_hearing/vestibular/ear_phenot2.67376471
15MP0001958_emphysema2.52325646
16MP0003252_abnormal_bile_duct2.44923642
17MP0008875_abnormal_xenobiotic_pharmacok2.31029304
18MP0008961_abnormal_basal_metabolism2.00711403
19MP0000538_abnormal_urinary_bladder1.95975785
20MP0005058_abnormal_lysosome_morphology1.90644990
21MP0005365_abnormal_bile_salt1.83013929
22MP0004885_abnormal_endolymph1.82998268
23MP0005085_abnormal_gallbladder_physiolo1.60723860
24MP0005584_abnormal_enzyme/coenzyme_acti1.53534819
25MP0003300_gastrointestinal_ulcer1.48742980
26MP0002168_other_aberrant_phenotype1.47655669
27MP0003186_abnormal_redox_activity1.43951669
28MP0002928_abnormal_bile_duct1.39646143
29MP0002135_abnormal_kidney_morphology1.29672616
30MP0005084_abnormal_gallbladder_morpholo1.28806596
31MP0002876_abnormal_thyroid_physiology1.26982418
32MP0003183_abnormal_peptide_metabolism1.25083925
33MP0005451_abnormal_body_composition1.24966491
34MP0000230_abnormal_systemic_arterial1.24179193
35MP0010234_abnormal_vibrissa_follicle1.24128371
36MP0005319_abnormal_enzyme/_coenzyme1.17883203
37MP0003283_abnormal_digestive_organ1.12807591
38MP0006036_abnormal_mitochondrial_physio1.08444512
39MP0002896_abnormal_bone_mineralization1.05364445
40MP0005083_abnormal_biliary_tract1.04459654
41MP0000534_abnormal_ureter_morphology1.01700960
42MP0003191_abnormal_cellular_cholesterol0.92806027
43MP0005535_abnormal_body_temperature0.90095086
44MP0003806_abnormal_nucleotide_metabolis0.89587780
45MP0005666_abnormal_adipose_tissue0.89315089
46MP0000678_abnormal_parathyroid_gland0.89137785
47MP0004264_abnormal_extraembryonic_tissu0.83140282
48MP0005670_abnormal_white_adipose0.82531183
49MP0004272_abnormal_basement_membrane0.81765866
50MP0003638_abnormal_response/metabolism_0.80748015
51MP0003943_abnormal_hepatobiliary_system0.80541175
52MP0009672_abnormal_birth_weight0.79051100
53MP0001666_abnormal_nutrient_absorption0.78743476
54MP0002089_abnormal_postnatal_growth/wei0.77181471
55MP0002796_impaired_skin_barrier0.77007460
56MP0001764_abnormal_homeostasis0.74936934
57MP0010368_abnormal_lymphatic_system0.74782536
58MP0005220_abnormal_exocrine_pancreas0.73885415
59MP0005395_other_phenotype0.73598811
60MP0003172_abnormal_lysosome_physiology0.73279431
61MP0003045_fibrosis0.73111560
62MP0002118_abnormal_lipid_homeostasis0.72410567
63MP0009642_abnormal_blood_homeostasis0.69123775
64MP0000747_muscle_weakness0.68024102
65MP0003959_abnormal_lean_body0.65339692
66MP0003646_muscle_fatigue0.61446027
67MP0008004_abnormal_stomach_pH0.59972023
68MP0010386_abnormal_urinary_bladder0.59352057
69MP0001270_distended_abdomen0.58295972
70MP0003938_abnormal_ear_development0.57483085
71MP0001661_extended_life_span0.57270747
72MP0000566_synostosis0.56648599
73MP0004147_increased_porphyrin_level0.56200743
74MP0005165_increased_susceptibility_to0.56126868
75MP0009764_decreased_sensitivity_to0.53863683
76MP0008872_abnormal_physiological_respon0.53622395
77MP0005501_abnormal_skin_physiology0.52413119
78MP0003795_abnormal_bone_structure0.49799559
79MP0005167_abnormal_blood-brain_barrier0.49018018
80MP0002971_abnormal_brown_adipose0.48924597
81MP0000609_abnormal_liver_physiology0.47964989
82MP0001944_abnormal_pancreas_morphology0.47467374
83MP0004742_abnormal_vestibular_system0.46777868
84MP0001963_abnormal_hearing_physiology0.46501786
85MP0002115_abnormal_skeleton_extremities0.46297511
86MP0000026_abnormal_inner_ear0.45520859
87MP0004858_abnormal_nervous_system0.43370028
88MP0003329_amyloid_beta_deposits0.43240382
89MP0001731_abnormal_postnatal_growth0.42609801
90MP0002098_abnormal_vibrissa_morphology0.42387453
91MP0003879_abnormal_hair_cell0.42147525
92MP0000681_abnormal_thyroid_gland0.42064566
93MP0000598_abnormal_liver_morphology0.41774812
94MP0010329_abnormal_lipoprotein_level0.41157817
95MP0005375_adipose_tissue_phenotype0.40911745
96MP0005408_hypopigmentation0.40781926
97MP0004233_abnormal_muscle_weight0.40578801
98MP0008469_abnormal_protein_level0.40270551
99MP0002069_abnormal_eating/drinking_beha0.40164624
100MP0003941_abnormal_skin_development0.39899366
101MP0003953_abnormal_hormone_level0.39163321
102MP0000163_abnormal_cartilage_morphology0.39022282
103MP0002998_abnormal_bone_remodeling0.38793044
104MP0001177_atelectasis0.37967608
105MP0003942_abnormal_urinary_system0.37633936
106MP0001191_abnormal_skin_condition0.37412240
107MP0000383_abnormal_hair_follicle0.37243271
108MP0000920_abnormal_myelination0.37187968
109MP0003315_abnormal_perineum_morphology0.36693006
110MP0010678_abnormal_skin_adnexa0.35918242
111MP0005409_darkened_coat_color0.35514992
112MP0002078_abnormal_glucose_homeostasis0.35431591
113MP0003566_abnormal_cell_adhesion0.35117636
114MP0000371_diluted_coat_color0.34908509
115MP0004484_altered_response_of0.34744785
116MP0000013_abnormal_adipose_tissue0.34573972
117MP0001501_abnormal_sleep_pattern0.33781028
118MP0003221_abnormal_cardiomyocyte_apopto0.33603596
119MP0001663_abnormal_digestive_system0.33492142
120MP0001485_abnormal_pinna_reflex0.33154083
121MP0001879_abnormal_lymphatic_vessel0.32384366
122MP0009703_decreased_birth_body0.31307538
123MP0008775_abnormal_heart_ventricle0.31050492
124MP0006035_abnormal_mitochondrial_morpho0.30752526
125MP0003690_abnormal_glial_cell0.27780776
126MP0000003_abnormal_adipose_tissue0.27055093
127MP0003868_abnormal_feces_composition0.23111679
128MP0008569_lethality_at_weaning0.21945371
129MP0003011_delayed_dark_adaptation0.21912605

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)8.95914529
2Hypokalemic alkalosis (HP:0001949)8.82450527
3Increased circulating renin level (HP:0000848)8.62212637
4Hyperactive renin-angiotensin system (HP:0000841)7.93621328
5Hypomagnesemia (HP:0002917)7.65486166
6Polyuria (HP:0000103)7.57321737
7Abnormality of chloride homeostasis (HP:0011422)7.51043824
8Abnormal urine output (HP:0012590)7.06301817
9Abnormality of renal excretion (HP:0011036)6.53070396
10Abnormality of magnesium homeostasis (HP:0004921)6.50401362
11Gout (HP:0001997)6.37882895
12Tetany (HP:0001281)6.16234689
13Renal salt wasting (HP:0000127)6.02240757
14Abnormal drinking behavior (HP:0030082)6.01800721
15Polydipsia (HP:0001959)6.01800721
16Hyperaldosteronism (HP:0000859)5.89397625
17Alkalosis (HP:0001948)5.43863017
18Abnormality of renin-angiotensin system (HP:0000847)5.40784526
19Hyperuricemia (HP:0002149)4.57966461
20Increased purine levels (HP:0004368)4.57966461
21Proximal tubulopathy (HP:0000114)4.46361885
22Hypokalemia (HP:0002900)4.37420223
23Hypercalciuria (HP:0002150)3.99580406
24Hyperglycinuria (HP:0003108)3.94608901
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83999184
26Abnormality of purine metabolism (HP:0004352)3.82449577
27Abnormality of potassium homeostasis (HP:0011042)3.58698238
28Generalized aminoaciduria (HP:0002909)3.23324034
29Abnormality of glycine metabolism (HP:0010895)3.19654650
30Abnormality of serine family amino acid metabolism (HP:0010894)3.19654650
31Renal tubular acidosis (HP:0001947)3.17588478
32Abnormality of sodium homeostasis (HP:0010931)3.16867275
33Large eyes (HP:0001090)3.16204636
34Ketoacidosis (HP:0001993)3.09289644
35Abnormality of fatty-acid metabolism (HP:0004359)3.00603693
36Hyponatremia (HP:0002902)2.90661889
37Glycosuria (HP:0003076)2.89808257
38Abnormality of urine glucose concentration (HP:0011016)2.89808257
39Nephrocalcinosis (HP:0000121)2.88614819
40Adrenal overactivity (HP:0002717)2.80490111
41Abnormality of nucleobase metabolism (HP:0010932)2.73053631
42Dehydration (HP:0001944)2.68075701
43Ketosis (HP:0001946)2.62928728
44Abnormality of proline metabolism (HP:0010907)2.54694549
45Hydroxyprolinuria (HP:0003080)2.54694549
46Hyperphosphaturia (HP:0003109)2.50622166
47Delayed epiphyseal ossification (HP:0002663)2.44447978
48Abnormal urine phosphate concentration (HP:0012599)2.39412047
49Nephrolithiasis (HP:0000787)2.35628297
50Chondrocalcinosis (HP:0000934)2.32788033
51Tubulointerstitial fibrosis (HP:0005576)2.30561480
52Facial shape deformation (HP:0011334)2.29464542
53Potter facies (HP:0002009)2.29464542
54Delayed CNS myelination (HP:0002188)2.27532583
55Abnormality of Sharpey fibers (HP:0100685)2.18223316
56Decreased circulating renin level (HP:0003351)2.18035094
57Tubular atrophy (HP:0000092)2.17741506
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13231627
59Hyperglycinemia (HP:0002154)2.12884578
60Hypophosphatemia (HP:0002148)2.12406985
61Metaphyseal cupping (HP:0003021)2.10936436
62Vomiting (HP:0002013)2.10824392
63Focal segmental glomerulosclerosis (HP:0000097)2.07277151
64Thyroid-stimulating hormone excess (HP:0002925)2.04972824
65Vascular calcification (HP:0004934)2.03787148
66Rickets (HP:0002748)2.00434737
67Vacuolated lymphocytes (HP:0001922)1.99543459
68Hypotension (HP:0002615)1.96041556
69Glomerulosclerosis (HP:0000096)1.95926452
70Hyperammonemia (HP:0001987)1.95768088
71Enlarged kidneys (HP:0000105)1.93787323
72Widely patent fontanelles and sutures (HP:0004492)1.90762657
73Generalized muscle weakness (HP:0003324)1.90221360
74Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88755441
75Dicarboxylic aciduria (HP:0003215)1.88755441
76Renal tubular dysfunction (HP:0000124)1.86070571
77Abnormal platelet function (HP:0011869)1.85760318
78Impaired platelet aggregation (HP:0003540)1.85760318
79Hypothermia (HP:0002045)1.84200248
80Metabolic acidosis (HP:0001942)1.84103231
81Cardiovascular calcification (HP:0011915)1.81379536
82Bicornuate uterus (HP:0000813)1.80941278
83Bilateral sensorineural hearing impairment (HP:0008619)1.79558819
84Abnormality of renal resorption (HP:0011038)1.77339123
85Thin bony cortex (HP:0002753)1.74838434
86Lymphangioma (HP:0100764)1.74705637
87Malnutrition (HP:0004395)1.73827703
88Neonatal onset (HP:0003623)1.69184705
89Abnormal enzyme/coenzyme activity (HP:0012379)1.66976514
90Lethargy (HP:0001254)1.66460056
91Confusion (HP:0001289)1.63763174
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.62823229
93Abnormality of alkaline phosphatase activity (HP:0004379)1.61948712
94Irritability (HP:0000737)1.57239973
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57212925
96Methylmalonic aciduria (HP:0012120)1.56807895
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.56118824
98Hyperkalemia (HP:0002153)1.55079202
99Abnormal tarsal ossification (HP:0008369)1.50840418
100Goiter (HP:0000853)1.48218344
101Tachypnea (HP:0002789)1.45263957
102Tubulointerstitial abnormality (HP:0001969)1.43998151
103Abnormality of the costochondral junction (HP:0000919)1.41815671
104Abnormality of the renal cortex (HP:0011035)1.41649865
105Metaphyseal irregularity (HP:0003025)1.40459037
106Nausea (HP:0002018)1.40251829
107Premature birth (HP:0001622)1.39910005
108Osteopenia (HP:0000938)1.33400793
109Elevated alkaline phosphatase (HP:0003155)1.23042371
110Neonatal death (HP:0003811)1.19617950
111Paresthesia (HP:0003401)1.18998570
112Nephrogenic diabetes insipidus (HP:0009806)1.17138806
113Abnormality of the renal medulla (HP:0100957)1.16281638
114Hypophosphatemic rickets (HP:0004912)1.13676321
115Abnormality of calcium-phosphate metabolism (HP:0100530)1.13040090
116Metaphyseal dysplasia (HP:0100255)1.10664624
117Small for gestational age (HP:0001518)1.05082780
118Polyhydramnios (HP:0001561)1.02346448
119Osteomalacia (HP:0002749)0.97541123
120Esophageal varix (HP:0002040)0.96250778
121Abnormality of macular pigmentation (HP:0008002)0.94785932
122Abnormality of carpal bone ossification (HP:0006257)0.94373220
123Abnormality of cochlea (HP:0000375)0.92255372
124Intellectual disability, moderate (HP:0002342)0.92245756
125Nuclear cataract (HP:0100018)0.88839822
126Chorioretinal atrophy (HP:0000533)0.88525140
127Choanal stenosis (HP:0000452)0.83913710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.66675120
2WNK48.27540915
3OXSR17.77242210
4STK393.95227425
5BCKDK2.41691772
6STK38L2.05211582
7SGK2231.93324034
8SGK4941.93324034
9WNK11.75564956
10PDK41.64883485
11PDK31.64883485
12NEK11.63615748
13MST41.38240075
14SGK21.35652768
15SGK31.24158821
16PDK21.21521614
17STK381.08060059
18MST1R1.07270853
19LRRK21.02241787
20PAK40.75586192
21EPHB10.71730398
22TIE10.70683896
23FRK0.68801114
24FGFR40.68294561
25TRIB30.66782552
26TGFBR20.61177705
27GSK3A0.60606219
28ERN10.57846867
29SGK10.56674637
30PTK20.56630398
31MAP2K60.54941102
32PTK60.53358514
33MAP3K30.52527372
34EPHA20.48185599
35STK100.47702719
36PINK10.47486965
37FER0.44763692
38MAP3K70.44294761
39GRK60.43700023
40PRKAA10.42478765
41DYRK1B0.39398925
42PAK30.38578871
43PRKCI0.38475984
44FGFR30.37837171
45MET0.36731730
46AKT30.36716087
47PDPK10.32058729
48MYLK0.31236697
49RIPK10.30361306
50ABL20.28278518
51NTRK10.26808906
52LATS10.26615793
53PRKD20.25876692
54MAP3K20.24844505
55EEF2K0.24808261
56PTK2B0.24664074
57CDK120.23487381
58PRKCZ0.23065390
59PRKAA20.22056831
60MAPK110.21337863
61RET0.20632769
62MAPK150.19135979
63EPHB20.18637906
64BMX0.17728623
65PRKCD0.17654183
66PDK10.16701373
67INSRR0.14965065
68NTRK30.14210613
69PRKACG0.13907573
70ICK0.13835382
71PDGFRA0.13149159
72PRKCH0.13137689
73AKT20.12574199
74MAPKAPK30.12088925
75PIK3CG0.11469021
76MAP2K20.10413022
77ERBB40.10087768
78NEK90.10061452
79MAP2K30.09781203
80KSR20.09198550
81PKN20.09041785
82CSNK1A10.09016758
83LMTK20.08720585
84ROCK10.08698888
85PRKACA0.08347925
86LATS20.08137935
87SCYL20.08134311
88MARK30.07694642
89CDC42BPA0.07556112
90PRKCA0.07148191
91TTN0.07078060
92PIK3CA0.06966029
93JAK20.06651640
94MAP3K140.06444158
95SRC0.06141454
96STK110.05901644
97CDK60.05586429
98MAP2K10.05320262
99INSR0.04543447
100MAP3K110.04431331
101DDR20.03928894
102MAP3K10.03655310
103DAPK20.03420948
104FGFR20.03051955
105MINK10.02732343
106PIM10.02493702
107RPS6KA30.02314591
108MTOR0.02311415
109TESK10.02100154
110SIK10.01437504
111MAP3K80.01057335
112KDR0.01034643
113PRKCB0.00934491
114TGFBR10.00857569
115CSF1R0.00795525
116IRAK20.00181306
117EPHA30.00064313
118MAPK3-0.0430676
119MAPK4-0.0396721
120PRKD1-0.0393415
121TYRO3-0.0351661
122MAPK8-0.0243570
123PRKCQ-0.0210028
124RPS6KA2-0.0205776
125NLK-0.0199145
126DMPK-0.0196566
127TRPM7-0.0163804
128IGF1R-0.0157297
129NME1-0.0146858
130SMG1-0.0106752
131ROCK2-0.0042898
132MATK-0.0036763
133FGFR1-0.0009104
134PRKCG-0.0007619

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.98437840
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41632390
3Butanoate metabolism_Homo sapiens_hsa006503.34779104
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.32014710
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.17446545
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.16781557
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.16581675
8Propanoate metabolism_Homo sapiens_hsa006403.16091620
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93851710
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.80982451
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51182878
12Collecting duct acid secretion_Homo sapiens_hsa049662.35166899
13Fatty acid degradation_Homo sapiens_hsa000712.34679022
14Pyruvate metabolism_Homo sapiens_hsa006202.28286768
15Peroxisome_Homo sapiens_hsa041462.27030798
16Tryptophan metabolism_Homo sapiens_hsa003802.07883024
17Vitamin digestion and absorption_Homo sapiens_hsa049772.00928017
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00298278
19Sulfur metabolism_Homo sapiens_hsa009201.87876455
20Bile secretion_Homo sapiens_hsa049761.85269300
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82237419
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77681325
23Carbon metabolism_Homo sapiens_hsa012001.77320909
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74255035
25Fatty acid metabolism_Homo sapiens_hsa012121.70026668
26beta-Alanine metabolism_Homo sapiens_hsa004101.67098552
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64212663
28Glutathione metabolism_Homo sapiens_hsa004801.60487307
29Mineral absorption_Homo sapiens_hsa049781.59694518
30Protein digestion and absorption_Homo sapiens_hsa049741.43373420
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40243359
32Complement and coagulation cascades_Homo sapiens_hsa046101.37364124
33Other glycan degradation_Homo sapiens_hsa005111.31758966
34Lysine degradation_Homo sapiens_hsa003101.22834320
35Arginine and proline metabolism_Homo sapiens_hsa003301.22622817
36Arginine biosynthesis_Homo sapiens_hsa002201.19750486
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19678817
38PPAR signaling pathway_Homo sapiens_hsa033201.18322003
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15498395
40Thyroid hormone synthesis_Homo sapiens_hsa049181.10772959
41Nitrogen metabolism_Homo sapiens_hsa009101.08362307
42Biosynthesis of amino acids_Homo sapiens_hsa012301.07599440
43Selenocompound metabolism_Homo sapiens_hsa004500.99361233
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96823325
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94022480
46Starch and sucrose metabolism_Homo sapiens_hsa005000.93442107
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89410531
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89168885
49Oxidative phosphorylation_Homo sapiens_hsa001900.84933254
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83500932
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80531933
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.79820846
53Phenylalanine metabolism_Homo sapiens_hsa003600.79121266
54Endometrial cancer_Homo sapiens_hsa052130.77398374
55Renin-angiotensin system_Homo sapiens_hsa046140.77199878
56Gastric acid secretion_Homo sapiens_hsa049710.77146072
57Non-small cell lung cancer_Homo sapiens_hsa052230.75874140
58Lysosome_Homo sapiens_hsa041420.75474134
59Glycerolipid metabolism_Homo sapiens_hsa005610.75362561
60Fructose and mannose metabolism_Homo sapiens_hsa000510.74570973
61Folate biosynthesis_Homo sapiens_hsa007900.73518462
62Histidine metabolism_Homo sapiens_hsa003400.72378045
63Pancreatic cancer_Homo sapiens_hsa052120.70350775
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.68131838
65Fatty acid elongation_Homo sapiens_hsa000620.67826269
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.60460387
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59389878
68Pentose phosphate pathway_Homo sapiens_hsa000300.58534237
69Chemical carcinogenesis_Homo sapiens_hsa052040.55054323
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51521719
71HIF-1 signaling pathway_Homo sapiens_hsa040660.51157810
72Parkinsons disease_Homo sapiens_hsa050120.47669811
73Thyroid cancer_Homo sapiens_hsa052160.46591107
74Metabolic pathways_Homo sapiens_hsa011000.46464664
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46076782
76Vibrio cholerae infection_Homo sapiens_hsa051100.44883177
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.44697384
78Melanoma_Homo sapiens_hsa052180.43870184
79Tyrosine metabolism_Homo sapiens_hsa003500.42932460
80Fat digestion and absorption_Homo sapiens_hsa049750.40249301
81Glioma_Homo sapiens_hsa052140.39064539
82Vitamin B6 metabolism_Homo sapiens_hsa007500.38224662
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.36405304
84FoxO signaling pathway_Homo sapiens_hsa040680.33394361
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.31145714
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29549020
87Retinol metabolism_Homo sapiens_hsa008300.28763668
88Cardiac muscle contraction_Homo sapiens_hsa042600.25657876
89ABC transporters_Homo sapiens_hsa020100.22570123
90Circadian rhythm_Homo sapiens_hsa047100.22546954
91Arachidonic acid metabolism_Homo sapiens_hsa005900.22142751
92Bladder cancer_Homo sapiens_hsa052190.21032659
93Prostate cancer_Homo sapiens_hsa052150.20714063
94Sulfur relay system_Homo sapiens_hsa041220.20540283
95ErbB signaling pathway_Homo sapiens_hsa040120.20241407
96Synaptic vesicle cycle_Homo sapiens_hsa047210.20080164
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19388127
98Alzheimers disease_Homo sapiens_hsa050100.19248691
99Choline metabolism in cancer_Homo sapiens_hsa052310.18113664
100Gap junction_Homo sapiens_hsa045400.17864866
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16129106
102ECM-receptor interaction_Homo sapiens_hsa045120.15965307
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14887052
104Sphingolipid metabolism_Homo sapiens_hsa006000.14645003
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.14330090
106Autoimmune thyroid disease_Homo sapiens_hsa053200.14174843
107Steroid biosynthesis_Homo sapiens_hsa001000.12400022
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.12080623
109Insulin resistance_Homo sapiens_hsa049310.11910567
110Fatty acid biosynthesis_Homo sapiens_hsa000610.10816911
111Tight junction_Homo sapiens_hsa045300.08893501
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07847202
113Inositol phosphate metabolism_Homo sapiens_hsa005620.06046020
114Rheumatoid arthritis_Homo sapiens_hsa053230.05693786
115Huntingtons disease_Homo sapiens_hsa050160.03887889
116AMPK signaling pathway_Homo sapiens_hsa041520.02713177
117Focal adhesion_Homo sapiens_hsa045100.01900231
118Hepatitis C_Homo sapiens_hsa051600.01225603
119Galactose metabolism_Homo sapiens_hsa00052-0.0040267
120Glucagon signaling pathway_Homo sapiens_hsa04922-0.0031557

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