CDH17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.20979962
2regulation of guanylate cyclase activity (GO:0031282)7.21809127
3UDP-N-acetylglucosamine metabolic process (GO:0006047)6.96816725
4vitamin A metabolic process (GO:0006776)6.83180668
5actin filament depolymerization (GO:0030042)6.65954207
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.25423101
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.98333907
8maintenance of gastrointestinal epithelium (GO:0030277)5.86455952
9digestive system process (GO:0022600)5.84023027
10epoxygenase P450 pathway (GO:0019373)5.59048022
11flavonoid metabolic process (GO:0009812)5.55124473
123-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.47915020
13purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.47915020
14cellular glucuronidation (GO:0052695)5.40597310
15adhesion of symbiont to host cell (GO:0044650)5.39500918
16virion attachment to host cell (GO:0019062)5.39500918
17positive regulation of guanylate cyclase activity (GO:0031284)5.27837120
18uronic acid metabolic process (GO:0006063)5.27066357
19glucuronate metabolic process (GO:0019585)5.27066357
20positive regulation of respiratory burst (GO:0060267)5.19617803
21intestinal epithelial cell development (GO:0060576)5.13872625
22regulation of bile acid biosynthetic process (GO:0070857)5.02896686
23regulation of cellular extravasation (GO:0002691)5.00267625
24fat-soluble vitamin biosynthetic process (GO:0042362)4.98078069
25drug catabolic process (GO:0042737)4.96862568
26sulfate transmembrane transport (GO:1902358)4.91142049
27receptor guanylyl cyclase signaling pathway (GO:0007168)4.89482915
28renal system process involved in regulation of blood volume (GO:0001977)4.60881304
29O-glycan processing (GO:0016266)4.60530618
30regulation of systemic arterial blood pressure (GO:0003073)4.59880044
31response to hepatocyte growth factor (GO:0035728)4.45058976
32cellular response to hepatocyte growth factor stimulus (GO:0035729)4.45058976
33hepatocyte apoptotic process (GO:0097284)4.42854180
34epithelial structure maintenance (GO:0010669)4.41537415
35regulation of cGMP biosynthetic process (GO:0030826)4.40750315
36regulation of vitamin metabolic process (GO:0030656)4.38577163
37adhesion of symbiont to host (GO:0044406)4.31648161
38drug metabolic process (GO:0017144)4.28426325
39bile acid and bile salt transport (GO:0015721)4.24533241
40glucose 6-phosphate metabolic process (GO:0051156)4.15664565
41sperm capacitation (GO:0048240)4.12584462
42bicarbonate transport (GO:0015701)4.11942980
43phospholipid efflux (GO:0033700)4.11710694
44digestion (GO:0007586)4.09228369
45sulfate transport (GO:0008272)4.07654711
46plasma lipoprotein particle assembly (GO:0034377)4.07509813
47lipoprotein metabolic process (GO:0042157)4.07067328
48glomerular filtration (GO:0003094)4.05155888
49sulfation (GO:0051923)4.03841120
50modified amino acid transport (GO:0072337)4.02246245
51positive regulation of pseudopodium assembly (GO:0031274)4.01415833
52protein-lipid complex assembly (GO:0065005)3.95174179
53sulfur compound transport (GO:0072348)3.92436667
54positive regulation of triglyceride lipase activity (GO:0061365)3.88453038
55positive regulation of lipoprotein lipase activity (GO:0051006)3.88453038
56urea cycle (GO:0000050)3.86009663
57oligosaccharide biosynthetic process (GO:0009312)3.79406721
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78562741
59transepithelial transport (GO:0070633)3.78165856
60very-low-density lipoprotein particle assembly (GO:0034379)3.74691677
61thyroid hormone metabolic process (GO:0042403)3.74507690
62ethanol oxidation (GO:0006069)3.72593394
63regulation of triglyceride catabolic process (GO:0010896)3.71284198
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.70276761
65antibacterial humoral response (GO:0019731)3.68186419
66regulation of cholesterol esterification (GO:0010872)3.67009002
67hormone catabolic process (GO:0042447)3.66496656
68urea metabolic process (GO:0019627)3.66375184
69renal filtration (GO:0097205)3.66015942
70regulation of actin nucleation (GO:0051125)3.65623744
71fructose metabolic process (GO:0006000)3.64527229
72antimicrobial humoral response (GO:0019730)3.64291208
73regulation of cGMP metabolic process (GO:0030823)3.63883812
74regulation of respiratory burst (GO:0060263)3.63694564
75auditory receptor cell differentiation (GO:0042491)3.62413507
76hemidesmosome assembly (GO:0031581)3.62291894
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.59027291
78regulation of pseudopodium assembly (GO:0031272)3.57799243
79regulation of cholesterol homeostasis (GO:2000188)3.57409198
80cGMP-mediated signaling (GO:0019934)3.56791884
81nucleotide-sugar biosynthetic process (GO:0009226)3.55208371
82positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48755965
83drinking behavior (GO:0042756)3.46655719
84peptide hormone processing (GO:0016486)3.46233750
85desmosome organization (GO:0002934)3.44966780
86peptide catabolic process (GO:0043171)3.44595839
87nucleotide-sugar metabolic process (GO:0009225)3.43628790
88diacylglycerol metabolic process (GO:0046339)3.43394257
89drug transmembrane transport (GO:0006855)3.43283309
90vitamin transmembrane transport (GO:0035461)3.40952024
91arginine metabolic process (GO:0006525)3.40477857
92cholesterol homeostasis (GO:0042632)3.39898763
93sterol homeostasis (GO:0055092)3.39108346
94transcytosis (GO:0045056)3.38427492
95thrombin receptor signaling pathway (GO:0070493)3.36883565
96nitrogen cycle metabolic process (GO:0071941)3.36480973
97drug transport (GO:0015893)3.36159599
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36125826
99glycosphingolipid catabolic process (GO:0046479)3.33853937
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.33363818
101lipoprotein transport (GO:0042953)3.33234660
102negative regulation of cholesterol transport (GO:0032375)3.32658382
103negative regulation of sterol transport (GO:0032372)3.32658382
104cholesterol efflux (GO:0033344)3.32326956
105cholesterol transport (GO:0030301)3.31476291
106sterol transport (GO:0015918)3.31476291
107glycolipid catabolic process (GO:0019377)3.31375167
108activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.27869919
109purine nucleotide salvage (GO:0032261)3.26922631
110renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.26621029
111alkaloid metabolic process (GO:0009820)3.25127010
112membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.23815997
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22800738
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.17603140
115NADH metabolic process (GO:0006734)3.16033169
116positive regulation of glycoprotein metabolic process (GO:1903020)3.15362444
117nucleoside diphosphate biosynthetic process (GO:0009133)3.13734005
118fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12874823
119glycerol metabolic process (GO:0006071)3.11580541
120glycosylceramide metabolic process (GO:0006677)3.11125118
121striated muscle atrophy (GO:0014891)3.10947301
122regulation of Golgi to plasma membrane protein transport (GO:0042996)3.10831589
123glucocorticoid biosynthetic process (GO:0006704)3.10141866
124positive regulation of lipid catabolic process (GO:0050996)3.08705663
125bile acid metabolic process (GO:0008206)3.08312673
126ventricular cardiac muscle cell action potential (GO:0086005)3.06861478
127positive regulation of cGMP biosynthetic process (GO:0030828)3.06597488
128antigen processing and presentation of endogenous antigen (GO:0019883)3.03914939
129labyrinthine layer development (GO:0060711)3.03243683
130sodium ion homeostasis (GO:0055078)3.02768566
131cGMP biosynthetic process (GO:0006182)3.02296618
132positive regulation of T cell differentiation in thymus (GO:0033089)3.02071549
133fucosylation (GO:0036065)3.01796117
134negative regulation of keratinocyte proliferation (GO:0010839)2.96871792
135exogenous drug catabolic process (GO:0042738)2.93772152
136regulation of viral release from host cell (GO:1902186)2.92697101
137innate immune response in mucosa (GO:0002227)2.91317092
138oligosaccharide catabolic process (GO:0009313)2.91241201
139response to hydroperoxide (GO:0033194)2.88338107
140protein O-linked glycosylation (GO:0006493)2.86617369
141regulation of systemic arterial blood pressure by hormone (GO:0001990)2.84359132
142regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.84359132
143endocrine process (GO:0050886)2.84359132
144membrane repolarization during action potential (GO:0086011)2.82713101
145defense response to fungus (GO:0050832)2.80430192
146trophectodermal cell differentiation (GO:0001829)2.79789537
147positive regulation of actin filament depolymerization (GO:0030836)2.75486324
148sphingomyelin metabolic process (GO:0006684)2.74365553
149tight junction assembly (GO:0070830)2.72593178
150positive regulation of fatty acid biosynthetic process (GO:0045723)2.69722881
151regulation of chemokine secretion (GO:0090196)2.69108783
152cell communication involved in cardiac conduction (GO:0086065)2.68961549
153phospholipid scrambling (GO:0017121)2.68776880
154intestinal absorption (GO:0050892)12.0513907
155intestinal cholesterol absorption (GO:0030299)10.3200119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.15323892
2CDX2_20551321_ChIP-Seq_CACO-2_Human6.10399991
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.15458212
4GATA4_25053715_ChIP-Seq_YYC3_Human3.45074259
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26308438
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.20966886
7GATA6_25053715_ChIP-Seq_YYC3_Human3.20280844
8SOX2_20726797_ChIP-Seq_SW620_Human3.08150469
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.82717647
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.73023400
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.42522192
12PPAR_26484153_Chip-Seq_NCI-H1993_Human2.27372037
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16958815
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14790056
15TCF4_18268006_ChIP-ChIP_LS174T_Human2.01973767
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.01926543
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.97950352
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96597100
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.92056247
20* KLF5_25053715_ChIP-Seq_YYC3_Human1.89293881
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.83912710
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83578958
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.81265428
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.77385460
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76195709
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74324940
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74317855
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74068356
29* RUNX1_27514584_Chip-Seq_MCF-7_Human1.65557025
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65205443
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63220978
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59941533
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59234748
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.56919693
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51329528
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.51167310
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50145707
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43237519
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40392196
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39914909
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39914909
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39168116
43AR_21909140_ChIP-Seq_LNCAP_Human1.39160146
44RACK7_27058665_Chip-Seq_MCF-7_Human1.37869064
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37466526
46GATA2_19941826_ChIP-Seq_K562_Human1.37208718
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.35333337
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32785862
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30680128
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.29403594
51* ATF3_27146783_Chip-Seq_COLON_Human1.26169560
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22646973
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.22474802
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21939194
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19419628
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16227112
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14753354
58CEBPB_22108803_ChIP-Seq_LS180_Human1.12774256
59LXR_22292898_ChIP-Seq_THP-1_Human1.11151838
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09959662
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.09762236
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09426687
63* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08977335
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07782746
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.06654242
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06527594
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05172813
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03579755
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02316151
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02066041
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00425478
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99844082
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.99445568
74GATA1_22025678_ChIP-Seq_K562_Human0.98421448
75RXR_22108803_ChIP-Seq_LS180_Human0.98358887
76CLOCK_20551151_ChIP-Seq_293T_Human0.97555062
77JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96722820
78CDX2_22108803_ChIP-Seq_LS180_Human0.96429074
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.95928480
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94246537
81BCL6_27268052_Chip-Seq_Bcells_Human0.93837810
82GATA1_19941826_ChIP-Seq_K562_Human0.93311357
83ELF5_23300383_ChIP-Seq_T47D_Human0.92995486
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92757248
85GATA3_24758297_ChIP-Seq_MCF-7_Human0.90667122
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89739614
87TP53_16413492_ChIP-PET_HCT116_Human0.89417796
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89417737
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88619371
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88520565
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88360508
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87860756
93BCOR_27268052_Chip-Seq_Bcells_Human0.87502611
94STAT1_20625510_ChIP-Seq_HELA_Human0.87330534
95SA1_27219007_Chip-Seq_Bcells_Human0.87277111
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86339137
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85941496
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.85339029
99* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85160770
100TP63_23658742_ChIP-Seq_EP156T_Human0.85103933
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84439053
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83033650
103CREB1_26743006_Chip-Seq_LNCaP_Human0.82906548
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.82255714
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81975852
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.81815161
107TET1_21451524_ChIP-Seq_MESCs_Mouse0.81223807
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81167755
109CJUN_26792858_Chip-Seq_BT549_Human0.80049057
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79590921
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78840477
112BCAT_22108803_ChIP-Seq_LS180_Human0.78526908
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77677238
114DROSHA_22980978_ChIP-Seq_HELA_Human0.77180025
115ZNF263_19887448_ChIP-Seq_K562_Human0.76748016
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76703523
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76326802
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76249486
119VDR_24787735_ChIP-Seq_THP-1_Human0.74329979
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73750789
121* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73592895
122TP63_22573176_ChIP-Seq_HFKS_Human0.72370416
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72261515
124CTCF_27219007_Chip-Seq_Bcells_Human0.71863262
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71202256
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70383048
127* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.70103915
128EGR1_19032775_ChIP-ChIP_M12_Human0.69435530
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69257968
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67519562
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65895582
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.65204600
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64974717
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64457891
135NANOG_20526341_ChIP-Seq_ESCs_Human0.64201882
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.64023690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.50555527
2MP0010234_abnormal_vibrissa_follicle5.71542085
3MP0001666_abnormal_nutrient_absorption5.47042058
4MP0004264_abnormal_extraembryonic_tissu4.29658168
5MP0000462_abnormal_digestive_system3.66912403
6MP0003866_abnormal_defecation3.61920180
7MP0003183_abnormal_peptide_metabolism3.09916901
8MP0005085_abnormal_gallbladder_physiolo2.95682381
9MP0003252_abnormal_bile_duct2.78113380
10MP0002822_catalepsy2.75560267
11MP0009840_abnormal_foam_cell2.59553224
12MP0001873_stomach_inflammation2.58438833
13MP0010155_abnormal_intestine_physiology2.57448926
14MP0002139_abnormal_hepatobiliary_system2.56119675
15MP0001663_abnormal_digestive_system2.53421023
16MP0010352_gastrointestinal_tract_polyps2.44280250
17MP0005381_digestive/alimentary_phenotyp2.40265740
18MP0000537_abnormal_urethra_morphology2.39952935
19MP0003300_gastrointestinal_ulcer2.38504672
20MP0008875_abnormal_xenobiotic_pharmacok2.38237079
21MP0000490_abnormal_crypts_of2.25487064
22MP0003878_abnormal_ear_physiology2.11139780
23MP0005377_hearing/vestibular/ear_phenot2.11139780
24MP0004147_increased_porphyrin_level2.08011490
25MP0006054_spinal_hemorrhage2.05892395
26MP0001664_abnormal_digestion2.04205543
27MP0000477_abnormal_intestine_morphology2.03463423
28MP0010329_abnormal_lipoprotein_level1.96771295
29MP0005409_darkened_coat_color1.86452780
30MP0000538_abnormal_urinary_bladder1.74176265
31MP0003705_abnormal_hypodermis_morpholog1.71977740
32MP0005365_abnormal_bile_salt1.69037258
33MP0005670_abnormal_white_adipose1.53882370
34MP0004043_abnormal_pH_regulation1.50705005
35MP0004019_abnormal_vitamin_homeostasis1.50446104
36MP0005084_abnormal_gallbladder_morpholo1.48841914
37MP0010678_abnormal_skin_adnexa1.44468664
38MP0002138_abnormal_hepatobiliary_system1.41708918
39MP0005167_abnormal_blood-brain_barrier1.40280868
40MP0001764_abnormal_homeostasis1.34667470
41MP0009379_abnormal_foot_pigmentation1.33084918
42MP0000465_gastrointestinal_hemorrhage1.32670495
43MP0001849_ear_inflammation1.30704362
44MP0003879_abnormal_hair_cell1.23293009
45MP0002796_impaired_skin_barrier1.22076352
46MP0003283_abnormal_digestive_organ1.21233415
47MP0001188_hyperpigmentation1.17106553
48MP0003724_increased_susceptibility_to1.16299241
49MP0002876_abnormal_thyroid_physiology1.13709370
50MP0000230_abnormal_systemic_arterial1.12685791
51MP0001501_abnormal_sleep_pattern1.08827860
52MP0005448_abnormal_energy_balance1.08733247
53MP0003191_abnormal_cellular_cholesterol1.07770223
54MP0004947_skin_inflammation1.07358340
55MP0002089_abnormal_postnatal_growth/wei1.07234424
56MP0004858_abnormal_nervous_system1.07108500
57MP0001756_abnormal_urination1.06673081
58MP0009697_abnormal_copulation1.05575891
59MP0003453_abnormal_keratinocyte_physiol1.03444544
60MP0009384_cardiac_valve_regurgitation1.00895208
61MP0002166_altered_tumor_susceptibility0.99175713
62MP0009643_abnormal_urine_homeostasis0.99065585
63MP0000516_abnormal_urinary_system0.96594054
64MP0005367_renal/urinary_system_phenotyp0.96594054
65MP0002098_abnormal_vibrissa_morphology0.95269521
66MP0002277_abnormal_respiratory_mucosa0.95036356
67MP0000467_abnormal_esophagus_morphology0.93349389
68MP0002254_reproductive_system_inflammat0.92612964
69MP0001765_abnormal_ion_homeostasis0.91223124
70MP0008872_abnormal_physiological_respon0.90323623
71MP0003868_abnormal_feces_composition0.89154562
72MP0005501_abnormal_skin_physiology0.87287888
73MP0005166_decreased_susceptibility_to0.85860327
74MP0001485_abnormal_pinna_reflex0.84998833
75MP0002009_preneoplasia0.84897684
76MP0000470_abnormal_stomach_morphology0.82073091
77MP0005310_abnormal_salivary_gland0.81170615
78MP0009053_abnormal_anal_canal0.79975250
79MP0005584_abnormal_enzyme/coenzyme_acti0.77739583
80MP0004270_analgesia0.77113033
81MP0002971_abnormal_brown_adipose0.76064754
82MP0003693_abnormal_embryo_hatching0.75909898
83MP0002006_tumorigenesis0.75424167
84MP0000609_abnormal_liver_physiology0.73973512
85MP0001216_abnormal_epidermal_layer0.71757391
86MP0005025_abnormal_response_to0.71752567
87MP0003303_peritoneal_inflammation0.69493737
88MP0008004_abnormal_stomach_pH0.68864022
89MP0002896_abnormal_bone_mineralization0.68699525
90MP0002118_abnormal_lipid_homeostasis0.68340547
91MP0009115_abnormal_fat_cell0.67639331
92MP0009780_abnormal_chondrocyte_physiolo0.66681458
93MP0003806_abnormal_nucleotide_metabolis0.66397790
94MP0003329_amyloid_beta_deposits0.65621584
95MP0005636_abnormal_mineral_homeostasis0.65443668
96MP0006082_CNS_inflammation0.64759546
97MP0005535_abnormal_body_temperature0.64658993
98MP0001790_abnormal_immune_system0.63831763
99MP0005387_immune_system_phenotype0.63831763
100MP0009642_abnormal_blood_homeostasis0.63751046
101MP0008469_abnormal_protein_level0.63336155
102MP0002136_abnormal_kidney_physiology0.62101613
103MP0005165_increased_susceptibility_to0.59986684
104MP0005332_abnormal_amino_acid0.59608183
105MP0009333_abnormal_splenocyte_physiolog0.58986052
106MP0000678_abnormal_parathyroid_gland0.57483891
107MP0001835_abnormal_antigen_presentation0.57476501
108MP0005451_abnormal_body_composition0.56490047
109MP0003718_maternal_effect0.56444166
110MP0009785_altered_susceptibility_to0.56132350
111MP0000613_abnormal_salivary_gland0.56019204
112MP0002132_abnormal_respiratory_system0.55333176
113MP0000604_amyloidosis0.54839835
114MP0003315_abnormal_perineum_morphology0.54712968
115MP0005666_abnormal_adipose_tissue0.54346424
116MP0003436_decreased_susceptibility_to0.54226533
117MP0003953_abnormal_hormone_level0.54112948
118MP0003941_abnormal_skin_development0.53069443
119MP0001845_abnormal_inflammatory_respons0.52867001
120MP0002163_abnormal_gland_morphology0.51425082
121MP0005319_abnormal_enzyme/_coenzyme0.49659036
122MP0010307_abnormal_tumor_latency0.49615184
123MP0000383_abnormal_hair_follicle0.49268738
124MP0003045_fibrosis0.48794916
125MP0005266_abnormal_metabolism0.48724140
126MP0002060_abnormal_skin_morphology0.47870212
127MP0002148_abnormal_hypersensitivity_rea0.46924475
128MP0001191_abnormal_skin_condition0.46823146
129MP0000377_abnormal_hair_follicle0.46531131
130MP0000566_synostosis0.46363043
131MP0008873_increased_physiological_sensi0.43454587
132MP0000427_abnormal_hair_cycle0.43310018
133MP0004782_abnormal_surfactant_physiolog0.42662830
134MP0003950_abnormal_plasma_membrane0.42394825
135MP0004484_altered_response_of0.41257746
136MP0001881_abnormal_mammary_gland0.41098747
137MP0005023_abnormal_wound_healing0.40436924

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.50984589
2Right ventricular cardiomyopathy (HP:0011663)6.57470550
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.82825434
4Decreased circulating renin level (HP:0003351)5.79586035
5Acanthocytosis (HP:0001927)5.60379830
6Malnutrition (HP:0004395)5.29747487
7Abnormality of renin-angiotensin system (HP:0000847)5.21207551
8Conjugated hyperbilirubinemia (HP:0002908)5.00090941
9Hypobetalipoproteinemia (HP:0003563)4.97077079
10Autoimmune thrombocytopenia (HP:0001973)4.95036097
11Chronic diarrhea (HP:0002028)4.81835249
12Alkalosis (HP:0001948)4.52796053
13Abdominal distention (HP:0003270)4.42913611
14Abnormality of proline metabolism (HP:0010907)4.36532289
15Hydroxyprolinuria (HP:0003080)4.36532289
16Cupped ribs (HP:0000887)4.36393075
17Autoimmune hemolytic anemia (HP:0001890)3.97144611
18Flat acetabular roof (HP:0003180)3.76602629
19Fat malabsorption (HP:0002630)3.70832127
20Hyperaldosteronism (HP:0000859)3.56094081
21Gastrointestinal dysmotility (HP:0002579)3.53580410
22Rectal prolapse (HP:0002035)3.49295307
23Villous atrophy (HP:0011473)3.43819133
24Abnormality of small intestinal villus morphology (HP:0011472)3.43819133
25Confusion (HP:0001289)3.43173084
26Systemic lupus erythematosus (HP:0002725)3.39704904
27Abnormal biliary tract morphology (HP:0012440)3.38244260
28Pigmentary retinal degeneration (HP:0001146)3.32556014
29Dehydration (HP:0001944)3.23201713
30Milia (HP:0001056)3.16236152
31Poikilocytosis (HP:0004447)3.11651282
32Hyperactive renin-angiotensin system (HP:0000841)3.11630335
33Pustule (HP:0200039)3.04007430
34Micronodular cirrhosis (HP:0001413)3.02009340
35Abnormality of chloride homeostasis (HP:0011422)3.00098506
36Hemorrhage of the eye (HP:0011885)2.96833679
37Abnormality of the gastric mucosa (HP:0004295)2.95737255
38Palpitations (HP:0001962)2.90738651
39Widely patent fontanelles and sutures (HP:0004492)2.89493368
40Mildly elevated creatine phosphokinase (HP:0008180)2.88149488
41Hypokalemia (HP:0002900)2.86909868
42Woolly hair (HP:0002224)2.84673733
43Congenital sensorineural hearing impairment (HP:0008527)2.82449521
44Abnormality of the 1st metacarpal (HP:0010009)2.82433364
45Pili torti (HP:0003777)2.76929904
46Hypolipoproteinemia (HP:0010981)2.74338528
47Biliary tract neoplasm (HP:0100574)2.73799046
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.73241971
49Progressive sensorineural hearing impairment (HP:0000408)2.70803694
50Increased IgE level (HP:0003212)2.70320509
51Abnormality of potassium homeostasis (HP:0011042)2.65457650
52Hyperammonemia (HP:0001987)2.64542649
53Proximal tubulopathy (HP:0000114)2.64074822
54Hyponatremia (HP:0002902)2.64007300
55Mesangial abnormality (HP:0001966)2.62133238
56Syncope (HP:0001279)2.59389654
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.58312355
58Nausea (HP:0002018)2.57717557
59Abnormal tarsal ossification (HP:0008369)2.57558615
60Eczematoid dermatitis (HP:0000976)2.54237633
61Abnormality of urine glucose concentration (HP:0011016)2.51601791
62Glycosuria (HP:0003076)2.51601791
63Fragile nails (HP:0001808)2.50107343
64Abnormality of vitamin B metabolism (HP:0004340)2.49923602
65Onycholysis (HP:0001806)2.49036011
66Abnormality of serine family amino acid metabolism (HP:0010894)2.44944045
67Abnormality of glycine metabolism (HP:0010895)2.44944045
68Atrophic scars (HP:0001075)2.41784587
69Xanthomatosis (HP:0000991)2.40534635
70B lymphocytopenia (HP:0010976)2.39666204
71Abnormality of B cell number (HP:0010975)2.39666204
72Abnormal glucose tolerance (HP:0001952)2.32978894
73Intrahepatic cholestasis (HP:0001406)2.31295885
74Ventricular fibrillation (HP:0001663)2.30612378
75Hypotension (HP:0002615)2.29132054
76Enlarged epiphyses (HP:0010580)2.28350256
77Plantar hyperkeratosis (HP:0007556)2.27030220
78Increased mean platelet volume (HP:0011877)2.25977071
79Curly hair (HP:0002212)2.24942731
80Progressive hearing impairment (HP:0001730)2.24355151
81Posterior subcapsular cataract (HP:0007787)2.23686476
82Metabolic alkalosis (HP:0200114)2.23103292
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22187316
84Dicarboxylic aciduria (HP:0003215)2.21887260
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21887260
86Severe combined immunodeficiency (HP:0004430)2.19014553
87Increased purine levels (HP:0004368)2.18049454
88Hyperuricemia (HP:0002149)2.18049454
89Neonatal short-limb short stature (HP:0008921)2.15915309
90Abnormal foot bone ossification (HP:0010675)2.15541716
91Goiter (HP:0000853)2.15017923
92Hypophosphatemia (HP:0002148)2.14474131
93Cerebral palsy (HP:0100021)2.14042290
94Steatorrhea (HP:0002570)2.13738494
95Renal tubular acidosis (HP:0001947)2.12490368
96Abnormality of carpal bone ossification (HP:0006257)2.12439810
97Ureteral stenosis (HP:0000071)2.12288294
98Hyperphosphatemia (HP:0002905)2.11237386
99Flattened epiphyses (HP:0003071)2.10173784
100Combined immunodeficiency (HP:0005387)2.09013156
101Thyroiditis (HP:0100646)2.08652370
102Delayed epiphyseal ossification (HP:0002663)2.07818068
103Pancreatitis (HP:0001733)2.06212270
104Potter facies (HP:0002009)2.06033644
105Facial shape deformation (HP:0011334)2.06033644
106Abnormality of vitamin metabolism (HP:0100508)2.05507869
107Microretrognathia (HP:0000308)2.04530746
108Uterine neoplasm (HP:0010784)2.04522908
109Cheilitis (HP:0100825)2.03595476
110Protuberant abdomen (HP:0001538)2.03015117
111Cone-rod dystrophy (HP:0000548)2.02075232
112Metabolic acidosis (HP:0001942)2.01126069
113Thin bony cortex (HP:0002753)2.00903277
114Neoplasm of the rectum (HP:0100743)2.00699832
115Ureteral obstruction (HP:0006000)2.00531541
116Abnormal platelet volume (HP:0011876)2.00323915
117Fragile skin (HP:0001030)2.00157239
118Hyperparathyroidism (HP:0000843)1.99048779
119Hyperkalemia (HP:0002153)1.98668961
120Abnormal hair laboratory examination (HP:0003328)1.98565970
121Symptomatic seizures (HP:0011145)1.98332459
122Abnormality of magnesium homeostasis (HP:0004921)1.98219329
123Abnormal albumin level (HP:0012116)1.98180895
124Hypoalbuminemia (HP:0003073)1.98180895
125Neoplasm of the small intestine (HP:0100833)1.97929205
126Nephrolithiasis (HP:0000787)1.96340088
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95274848
128Adrenal overactivity (HP:0002717)1.94631598
129Late onset (HP:0003584)1.94286194
130Abnormality of the costochondral junction (HP:0000919)1.94147365
131Megaloblastic anemia (HP:0001889)1.94122794
132Male infertility (HP:0003251)1.93357027
133Hypercholesterolemia (HP:0003124)1.93329621
134Visceral angiomatosis (HP:0100761)1.93180130
135Abnormality of purine metabolism (HP:0004352)1.91789255
136Flat capital femoral epiphysis (HP:0003370)1.91251778
137Abnormality of sodium homeostasis (HP:0010931)1.90473547
138Glomerulosclerosis (HP:0000096)1.89411217
139Growth hormone excess (HP:0000845)1.86173521
140Hypoplasia of dental enamel (HP:0006297)1.85709707
141Glomerulonephritis (HP:0000099)1.85639107
142Abnormality of nucleobase metabolism (HP:0010932)1.84850485
143Wide cranial sutures (HP:0010537)1.84497253
144Focal segmental glomerulosclerosis (HP:0000097)1.83808462
145Hyperglycinuria (HP:0003108)1.83075612
146Symphalangism affecting the phalanges of the hand (HP:0009773)1.82961586
147Reticulocytosis (HP:0001923)1.82343132
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81437901
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80378250
150Abnormal urine phosphate concentration (HP:0012599)1.78407405
151Nephritis (HP:0000123)1.78269185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.08554029
2FRK6.84585570
3LMTK26.39801177
4MST45.04868464
5MST1R4.76045334
6PRKG23.62756166
7MAP2K22.71149756
8NME12.66991562
9EPHA22.63434489
10GRK62.26235088
11RIPK12.15113477
12TESK12.14994359
13PIK3CA2.14738508
14PTK62.04322445
15EPHB21.99645688
16MAP3K101.98862691
17MAP3K21.82675786
18NUAK11.76549282
19AKT31.74814215
20MYLK1.65733935
21MET1.61886615
22FGFR41.53117549
23EPHA31.43460599
24TNIK1.21670436
25STK101.15977067
26WNK41.14511937
27ERN11.12850326
28PAK41.02129809
29CASK0.98628960
30MAP2K10.96798566
31MAP3K120.95804237
32TTK0.93687740
33PTK20.93123937
34MAP2K60.92269556
35LATS10.91367269
36FGFR30.91146686
37PRKCI0.89180892
38LIMK10.88660766
39PBK0.88646151
40DDR20.88111304
41FER0.87374944
42MAP3K80.84570996
43MATK0.84107876
44ERBB20.79050107
45RIPK40.77309973
46NLK0.77281285
47TAOK10.76991088
48TESK20.75548123
49PKN20.72887611
50BMX0.72477524
51EEF2K0.71640999
52EPHB10.71188682
53PRKAA20.70705386
54KSR20.69524618
55TAOK30.69293017
56EPHA40.64763786
57MAP3K70.62649176
58SCYL20.62309099
59STK30.60524628
60MAPK110.60414992
61MAP4K10.58785133
62MAP3K110.57522420
63CAMK2D0.55738064
64IRAK10.50315948
65MAP3K10.48205408
66ABL20.47601454
67AURKB0.47305458
68GRK10.46619655
69PRPF4B0.46309697
70DMPK0.44730245
71PRKAA10.44615782
72LRRK20.44158159
73BMPR20.43708732
74MAP3K30.42021698
75MAPKAPK30.41518880
76PRKCZ0.40705570
77MAP3K140.40577315
78TBK10.39533987
79ADRBK20.39285731
80RPS6KB20.38670508
81STK240.35718283
82CSK0.35410276
83PDPK10.34314193
84IKBKE0.32994286
85JAK10.32635754
86SRC0.32010588
87PIM20.31535647
88ZAP700.31238121
89MAPKAPK20.31054793
90CDK60.31035605
91STK390.30881054
92RET0.30714469
93CAMK2B0.29586894
94CDK190.29345343
95PAK30.28891681
96ROCK10.28755210
97PRKCA0.28684558
98CAMK2G0.27902463
99PAK10.27794212
100ICK0.26989849
101YES10.26522664
102CSNK1A10.25948236
103ERBB40.25615279
104PIM10.25295457
105JAK20.25221116
106PDK10.25181424
107DYRK1B0.25051676
108IGF1R0.24885678
109LYN0.24824183
110DAPK20.24773882
111PAK20.23862297
112MELK0.23253325
113NEK60.22977609
114CSF1R0.21839796
115AKT20.21625283
116SYK0.20323644
117CDK90.19445165
118PDK20.19124678
119FGR0.18325286
120MAP3K90.17884930
121OXSR10.17542582
122PRKCD0.17461821
123PRKCQ0.16706445
124MAP3K130.16586881
125ITK0.16459274
126TXK0.15626561
127PRKACG0.15577060
128KIT0.15545300
129RPS6KA20.15513205
130CDC42BPA0.15264145
131FYN0.14892503
132LCK0.13174496
133TYK20.12546312

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.40031574
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.73265483
3Mineral absorption_Homo sapiens_hsa049784.58171686
4Renin-angiotensin system_Homo sapiens_hsa046143.92478284
5Sulfur metabolism_Homo sapiens_hsa009203.84008110
6Vitamin digestion and absorption_Homo sapiens_hsa049773.24248818
7Galactose metabolism_Homo sapiens_hsa000522.77171500
8Caffeine metabolism_Homo sapiens_hsa002322.47256471
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.47015725
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.40848005
11Starch and sucrose metabolism_Homo sapiens_hsa005002.31872863
12Bile secretion_Homo sapiens_hsa049762.29204975
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.27893035
14Protein digestion and absorption_Homo sapiens_hsa049742.14802558
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.13886248
16Fructose and mannose metabolism_Homo sapiens_hsa000512.13006693
17Histidine metabolism_Homo sapiens_hsa003401.90564214
18Folate biosynthesis_Homo sapiens_hsa007901.87671056
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83118066
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79454448
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73110973
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44827950
23Glutathione metabolism_Homo sapiens_hsa004801.27820709
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21075221
25Glycerolipid metabolism_Homo sapiens_hsa005611.15502827
26Sphingolipid metabolism_Homo sapiens_hsa006001.12447117
27Asthma_Homo sapiens_hsa053101.11984918
28Tryptophan metabolism_Homo sapiens_hsa003801.08975846
29PPAR signaling pathway_Homo sapiens_hsa033201.07400655
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99934796
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99539341
32Tight junction_Homo sapiens_hsa045300.99507218
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98409420
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.97042841
35Fatty acid degradation_Homo sapiens_hsa000710.92738666
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92312512
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91988426
38Nitrogen metabolism_Homo sapiens_hsa009100.89744047
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88305551
40Pancreatic secretion_Homo sapiens_hsa049720.87848979
41Thyroid hormone synthesis_Homo sapiens_hsa049180.86455866
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85614275
43Allograft rejection_Homo sapiens_hsa053300.85373141
44Arginine and proline metabolism_Homo sapiens_hsa003300.80513836
45Autoimmune thyroid disease_Homo sapiens_hsa053200.79905324
46Pentose phosphate pathway_Homo sapiens_hsa000300.77471492
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.76981723
48ABC transporters_Homo sapiens_hsa020100.76523356
49Graft-versus-host disease_Homo sapiens_hsa053320.75860049
50Arginine biosynthesis_Homo sapiens_hsa002200.75062720
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74296740
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.73960392
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73687021
54Other glycan degradation_Homo sapiens_hsa005110.70352621
55Type I diabetes mellitus_Homo sapiens_hsa049400.62482385
56Phenylalanine metabolism_Homo sapiens_hsa003600.62146340
57Salmonella infection_Homo sapiens_hsa051320.60765127
58Thyroid cancer_Homo sapiens_hsa052160.60480054
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60154745
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.60137689
61Staphylococcus aureus infection_Homo sapiens_hsa051500.58527334
62Adherens junction_Homo sapiens_hsa045200.57875933
63Linoleic acid metabolism_Homo sapiens_hsa005910.55980713
64Pyruvate metabolism_Homo sapiens_hsa006200.54574694
65Peroxisome_Homo sapiens_hsa041460.54491524
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52887599
67Carbon metabolism_Homo sapiens_hsa012000.52078634
68Sulfur relay system_Homo sapiens_hsa041220.50008879
69Hepatitis C_Homo sapiens_hsa051600.49418761
70Arachidonic acid metabolism_Homo sapiens_hsa005900.49355227
71Bladder cancer_Homo sapiens_hsa052190.49330342
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48662174
73Gastric acid secretion_Homo sapiens_hsa049710.47663628
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45054961
75African trypanosomiasis_Homo sapiens_hsa051430.44451755
76Chemical carcinogenesis_Homo sapiens_hsa052040.43290390
77beta-Alanine metabolism_Homo sapiens_hsa004100.39412714
78Tyrosine metabolism_Homo sapiens_hsa003500.37210763
79Vibrio cholerae infection_Homo sapiens_hsa051100.37021575
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36665068
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.36448826
82Salivary secretion_Homo sapiens_hsa049700.35900952
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34751911
84Antigen processing and presentation_Homo sapiens_hsa046120.33635391
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32627161
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32185315
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31392282
88Type II diabetes mellitus_Homo sapiens_hsa049300.31275059
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30402811
90Ether lipid metabolism_Homo sapiens_hsa005650.28679141
91Retinol metabolism_Homo sapiens_hsa008300.28558396
92Insulin resistance_Homo sapiens_hsa049310.27703857
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27293720
94N-Glycan biosynthesis_Homo sapiens_hsa005100.26345540
95Propanoate metabolism_Homo sapiens_hsa006400.25521335
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.25330064
97Inositol phosphate metabolism_Homo sapiens_hsa005620.24248716
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22904338
99Hematopoietic cell lineage_Homo sapiens_hsa046400.22868416
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.22858772
101Leishmaniasis_Homo sapiens_hsa051400.22019480
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21797225
103Metabolic pathways_Homo sapiens_hsa011000.21490331
104Steroid biosynthesis_Homo sapiens_hsa001000.20972607
105Influenza A_Homo sapiens_hsa051640.20076579
106Legionellosis_Homo sapiens_hsa051340.18790354
107Toxoplasmosis_Homo sapiens_hsa051450.18081749
108GnRH signaling pathway_Homo sapiens_hsa049120.16964197
109Selenocompound metabolism_Homo sapiens_hsa004500.14201076
110Pertussis_Homo sapiens_hsa051330.13811449
111TNF signaling pathway_Homo sapiens_hsa046680.13117640
112Butanoate metabolism_Homo sapiens_hsa006500.13105268
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.11867454
114Fatty acid biosynthesis_Homo sapiens_hsa000610.11313483
115Amoebiasis_Homo sapiens_hsa051460.10909409
116Fatty acid metabolism_Homo sapiens_hsa012120.10636529
117Biosynthesis of amino acids_Homo sapiens_hsa012300.10366752
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.08851176
119Viral myocarditis_Homo sapiens_hsa054160.07946263
120Small cell lung cancer_Homo sapiens_hsa052220.07345237
121Endometrial cancer_Homo sapiens_hsa052130.07113854
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.06846259
123Insulin secretion_Homo sapiens_hsa049110.06075496
124Renin secretion_Homo sapiens_hsa049240.05530839
125Apoptosis_Homo sapiens_hsa042100.05463326
126Ovarian steroidogenesis_Homo sapiens_hsa049130.05160481
127HIF-1 signaling pathway_Homo sapiens_hsa040660.04876095
128Cocaine addiction_Homo sapiens_hsa050300.04314950
129Glucagon signaling pathway_Homo sapiens_hsa049220.01732302
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.00064655
131Fatty acid elongation_Homo sapiens_hsa00062-0.0012317

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