CDH19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.00147523
2ensheathment of neurons (GO:0007272)6.80293224
3axon ensheathment (GO:0008366)6.80293224
4myelination (GO:0042552)6.72955299
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.47794547
6regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.98388518
7regulation of actin filament-based movement (GO:1903115)5.53725156
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.51825375
9sarcomere organization (GO:0045214)5.32687223
10long-chain fatty acid biosynthetic process (GO:0042759)5.30870258
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.21619411
12cardiac muscle hypertrophy (GO:0003300)5.06001002
13myelin maintenance (GO:0043217)5.03093949
14cardiac muscle contraction (GO:0060048)4.80945012
15striated muscle hypertrophy (GO:0014897)4.77284401
16melanocyte differentiation (GO:0030318)4.70060169
17negative regulation of protein localization to cell surface (GO:2000009)4.61833995
18regulation of cell communication by electrical coupling (GO:0010649)4.61762498
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.60173522
20L-amino acid import (GO:0043092)4.58297824
21regulation of cardiac muscle cell contraction (GO:0086004)4.53228672
22cholesterol biosynthetic process (GO:0006695)4.51196549
23pigment cell differentiation (GO:0050931)4.49139080
24negative regulation of neurotransmitter secretion (GO:0046929)4.46940885
25oligodendrocyte differentiation (GO:0048709)4.41690941
26negative regulation of neurotransmitter transport (GO:0051589)4.39494780
27establishment of mitochondrion localization (GO:0051654)4.37871503
28regulation of relaxation of muscle (GO:1901077)4.36414647
29glycerophospholipid catabolic process (GO:0046475)4.32172337
30cardiac myofibril assembly (GO:0055003)4.30404650
31myelination in peripheral nervous system (GO:0022011)4.27615692
32peripheral nervous system axon ensheathment (GO:0032292)4.27615692
33creatine metabolic process (GO:0006600)4.22340325
34muscle hypertrophy (GO:0014896)4.20481279
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.17317115
36regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.16620726
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.16148981
38detection of calcium ion (GO:0005513)4.15520307
39heart contraction (GO:0060047)4.11567840
40heart process (GO:0003015)4.11567840
41eye photoreceptor cell differentiation (GO:0001754)4.04938309
42photoreceptor cell differentiation (GO:0046530)4.04938309
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.04912040
44regulation of striated muscle contraction (GO:0006942)3.98710434
45sterol biosynthetic process (GO:0016126)3.97273718
46cell communication involved in cardiac conduction (GO:0086065)3.96306984
47astrocyte development (GO:0014002)3.96000214
48response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.95298555
49cardiac muscle tissue morphogenesis (GO:0055008)3.89013369
50long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.85885756
51presynaptic membrane organization (GO:0097090)3.85880408
52regulation of cardiac muscle contraction (GO:0055117)3.83219822
53asymmetric protein localization (GO:0008105)3.83159381
54cGMP-mediated signaling (GO:0019934)3.81151250
55presynaptic membrane assembly (GO:0097105)3.79484523
56myofibril assembly (GO:0030239)3.78668545
57ventricular cardiac muscle cell action potential (GO:0086005)3.74738579
58short-term memory (GO:0007614)3.72526031
59peptidyl-tyrosine autophosphorylation (GO:0038083)3.71678834
60muscle filament sliding (GO:0030049)3.69241585
61actin-myosin filament sliding (GO:0033275)3.69241585
62regulation of the force of heart contraction (GO:0002026)3.64066734
63regulation of collateral sprouting (GO:0048670)3.62685954
64import into cell (GO:0098657)3.62503134
65response to lipoprotein particle (GO:0055094)3.62339565
66amino acid import (GO:0043090)3.61164065
67cardiac muscle adaptation (GO:0014887)3.58378161
68cardiac muscle hypertrophy in response to stress (GO:0014898)3.58378161
69muscle hypertrophy in response to stress (GO:0003299)3.58378161
70regulation of membrane repolarization (GO:0060306)3.57057331
71cell communication by electrical coupling (GO:0010644)3.55070610
72response to epinephrine (GO:0071871)3.53790486
73regulation of heart rate (GO:0002027)3.50610064
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.50105537
75muscle tissue morphogenesis (GO:0060415)3.50072320
76cardiac muscle cell development (GO:0055013)3.47482054
77neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.45846285
78positive regulation of vascular permeability (GO:0043117)3.44811162
79neuronal action potential propagation (GO:0019227)3.44561870
80adrenergic receptor signaling pathway (GO:0071875)3.44486677
81regulation of lipoprotein metabolic process (GO:0050746)3.43806790
82calcium-mediated signaling using intracellular calcium source (GO:0035584)3.42457948
83apical protein localization (GO:0045176)3.42388757
84inositol phosphate-mediated signaling (GO:0048016)3.41916718
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.41909427
86positive regulation of heart rate (GO:0010460)3.40927403
87actomyosin structure organization (GO:0031032)3.40771549
88striated muscle contraction (GO:0006941)3.40628288
89relaxation of cardiac muscle (GO:0055119)3.38355094
90magnesium ion transport (GO:0015693)3.37091349
91cardiac muscle cell action potential (GO:0086001)3.36888372
92amyloid precursor protein metabolic process (GO:0042982)3.33840933
93isoprenoid biosynthetic process (GO:0008299)3.33685154
94positive regulation of oligodendrocyte differentiation (GO:0048714)3.32512145
95response to methylmercury (GO:0051597)3.32398686
96fatty-acyl-CoA biosynthetic process (GO:0046949)3.32374241
97neurotransmitter uptake (GO:0001504)3.26765966
98response to redox state (GO:0051775)3.25988535
99bundle of His cell to Purkinje myocyte communication (GO:0086069)3.22385056
100cerebral cortex radially oriented cell migration (GO:0021799)3.22124666
101cardiac muscle cell action potential involved in contraction (GO:0086002)3.21082147
102negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.20737401
103response to inactivity (GO:0014854)3.20331932
104adult walking behavior (GO:0007628)3.18386963
105cardiac cell development (GO:0055006)3.16534750
106adult heart development (GO:0007512)3.16054769
107substantia nigra development (GO:0021762)3.14715872
108cellular response to epinephrine stimulus (GO:0071872)3.14621321
109negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.13057986
110actin-mediated cell contraction (GO:0070252)3.10980380
111limb bud formation (GO:0060174)3.10239380
112tyrosine metabolic process (GO:0006570)3.09782304
113protein localization to endosome (GO:0036010)3.08393116
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08199482
115neuroepithelial cell differentiation (GO:0060563)3.05946453
116axon development (GO:0061564)3.04453679
117L-serine transport (GO:0015825)3.03331889
118protein palmitoylation (GO:0018345)3.02209072
119virion attachment to host cell (GO:0019062)3.00463037
120adhesion of symbiont to host cell (GO:0044650)3.00463037
121regulation of heart contraction (GO:0008016)3.00084984
122negative regulation of smooth muscle cell differentiation (GO:0051151)2.98247062
123melanin biosynthetic process (GO:0042438)2.98217095
124positive regulation of action potential (GO:0045760)2.97442032
125peripheral nervous system development (GO:0007422)2.97329215
126regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96680343
127fatty-acyl-CoA metabolic process (GO:0035337)2.96465362
128very long-chain fatty acid metabolic process (GO:0000038)2.96302835
129membrane tubulation (GO:0097320)2.96083567
130negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95993400
131ventricular cardiac muscle cell development (GO:0055015)2.95187928
132phenol-containing compound biosynthetic process (GO:0046189)2.90634850
133cyclic nucleotide catabolic process (GO:0009214)2.89708119
134negative regulation of axonogenesis (GO:0050771)2.89685463
135sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87747788
136regulation of calcium ion transmembrane transport (GO:1903169)2.87263308
137regulation of calcium ion transmembrane transporter activity (GO:1901019)2.87263308
138glycosylceramide metabolic process (GO:0006677)2.83299806
139transmission of nerve impulse (GO:0019226)2.81359693
140fatty acid transmembrane transport (GO:1902001)2.80205576
141fusion of sperm to egg plasma membrane (GO:0007342)2.79470214
142melanosome organization (GO:0032438)2.79227736
143phasic smooth muscle contraction (GO:0014821)2.77981925
144cardiac conduction (GO:0061337)2.77361372
145regulation of sarcomere organization (GO:0060297)2.77060608
146regulation of somitogenesis (GO:0014807)2.76969354
147piRNA metabolic process (GO:0034587)2.76787048
148negative regulation of potassium ion transmembrane transport (GO:1901380)2.75920965
149thioester biosynthetic process (GO:0035384)2.75325867
150acyl-CoA biosynthetic process (GO:0071616)2.75325867
151GPI anchor metabolic process (GO:0006505)2.74007543
152negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72636199
153negative regulation of calcium ion transmembrane transport (GO:1903170)2.72636199
154carnitine shuttle (GO:0006853)2.70478435
155relaxation of muscle (GO:0090075)2.70045505
156melanin metabolic process (GO:0006582)2.68244149
157acrosome reaction (GO:0007340)2.67855946
158nerve growth factor signaling pathway (GO:0038180)2.65790029
159enteric nervous system development (GO:0048484)2.65456562
160negative regulation of JUN kinase activity (GO:0043508)2.64168160
161negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.63310919
162Golgi to endosome transport (GO:0006895)2.62286490
163neuronal ion channel clustering (GO:0045161)2.56813803
164GPI anchor biosynthetic process (GO:0006506)2.56696367
165response to dietary excess (GO:0002021)2.56638392
166membrane assembly (GO:0071709)2.54861692
167detection of temperature stimulus (GO:0016048)2.54668362
168serine transport (GO:0032329)2.53824845
169establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52988260
170mitochondrion transport along microtubule (GO:0047497)2.52988260
171potassium ion import (GO:0010107)2.52195701
172cranial nerve development (GO:0021545)2.51341952
173glial cell development (GO:0021782)2.50511339
174Leydig cell differentiation (GO:0033327)2.46707224
175positive regulation of cellular amine metabolic process (GO:0033240)2.46407302
176glial cell differentiation (GO:0010001)2.46327829
177detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.45806186
178detection of temperature stimulus involved in sensory perception (GO:0050961)2.45806186
179amyloid precursor protein catabolic process (GO:0042987)2.45155674
180preassembly of GPI anchor in ER membrane (GO:0016254)2.45065153
181leukocyte migration involved in inflammatory response (GO:0002523)2.44941255
182regulation of voltage-gated calcium channel activity (GO:1901385)2.44884519
183organ growth (GO:0035265)2.43597891
184secondary metabolite biosynthetic process (GO:0044550)2.42745434
185neuron cell-cell adhesion (GO:0007158)2.42515427
186negative regulation of axon extension (GO:0030517)2.40918570
187neuron remodeling (GO:0016322)2.40853096
188cellular response to cholesterol (GO:0071397)2.40039255
189central nervous system myelination (GO:0022010)10.5898835
190axon ensheathment in central nervous system (GO:0032291)10.5898835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53853960
2GBX2_23144817_ChIP-Seq_PC3_Human3.44506260
3* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.62842628
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36082066
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34582016
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31170879
7AR_21572438_ChIP-Seq_LNCaP_Human2.27846538
8EZH2_22144423_ChIP-Seq_EOC_Human2.24409069
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14412857
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11286640
11* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07806325
12TAF15_26573619_Chip-Seq_HEK293_Human2.03081965
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02862114
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01494057
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01494057
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01419633
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.96300601
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.93513001
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92794945
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88743230
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87316838
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85851952
23* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83562667
24* EZH2_27294783_Chip-Seq_NPCs_Mouse1.82148348
25* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80518587
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.80373259
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79548342
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.78614700
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.78326501
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.74555575
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72673377
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.71600913
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71430231
34* NFE2_27457419_Chip-Seq_LIVER_Mouse1.70569290
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69018377
36ER_23166858_ChIP-Seq_MCF-7_Human1.68057412
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65471787
38DROSHA_22980978_ChIP-Seq_HELA_Human1.64521059
39* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64205187
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.63004403
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61862520
42IGF1R_20145208_ChIP-Seq_DFB_Human1.53467147
43GATA1_22025678_ChIP-Seq_K562_Human1.51626386
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51220472
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.48304394
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.47212856
47* E2F1_18555785_Chip-Seq_ESCs_Mouse1.47189032
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46183118
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41908037
50BCAT_22108803_ChIP-Seq_LS180_Human1.41319892
51CJUN_26792858_Chip-Seq_BT549_Human1.41188160
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41054117
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40866570
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40170460
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39707481
56* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39438380
57* CRX_20693478_ChIP-Seq_RETINA_Mouse1.38572658
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38260941
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37283723
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.37232829
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.37232829
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36462422
63* P300_19829295_ChIP-Seq_ESCs_Human1.34958032
64* P53_22387025_ChIP-Seq_ESCs_Mouse1.34285747
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.33830637
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33504990
67* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33153318
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31204179
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30987496
70* SOX2_18555785_Chip-Seq_ESCs_Mouse1.30440115
71* STAT3_18555785_Chip-Seq_ESCs_Mouse1.28242070
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27626752
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27626752
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26544776
75STAT3_23295773_ChIP-Seq_U87_Human1.25983845
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21991024
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21480843
78SMAD4_21799915_ChIP-Seq_A2780_Human1.21259403
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21257391
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19210139
81* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19019603
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.18282707
83FUS_26573619_Chip-Seq_HEK293_Human1.18168046
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.17921961
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.16006154
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15283470
87* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15180189
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.14771243
89* ZFX_18555785_Chip-Seq_ESCs_Mouse1.14716762
90VDR_22108803_ChIP-Seq_LS180_Human1.14583217
91* CTCF_18555785_Chip-Seq_ESCs_Mouse1.12036528
92TP53_18474530_ChIP-ChIP_U2OS_Human1.11967459
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11433912
94TP53_16413492_ChIP-PET_HCT116_Human1.10780709
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.10184025
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10150642
97* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08764618
98EWS_26573619_Chip-Seq_HEK293_Human1.08717726
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08619090
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08035502
101HTT_18923047_ChIP-ChIP_STHdh_Human1.08016814
102* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07944187
103* PU1_27457419_Chip-Seq_LIVER_Mouse1.07763329
104* OCT4_18555785_Chip-Seq_ESCs_Mouse1.07712549
105* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07633246
106* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06980796
107* NMYC_18555785_Chip-Seq_ESCs_Mouse1.06642092
108TCF4_22108803_ChIP-Seq_LS180_Human1.05913131
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05829008
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05534437
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.05309181
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05303269
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04940712
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04013862
115CDX2_22108803_ChIP-Seq_LS180_Human1.03956327
116TCF4_23295773_ChIP-Seq_U87_Human1.03891063
117REST_21632747_ChIP-Seq_MESCs_Mouse1.03825431
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02632192
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02139301
120* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01766602
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.01335231
122* CMYC_18555785_Chip-Seq_ESCs_Mouse1.01226948
123AHR_22903824_ChIP-Seq_MCF-7_Human1.00421241
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00194838
125* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99777334
126* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99239750
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98180979
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98022464
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97910193
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96944994
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.96723265
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96454746
133* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94497657
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94383181
135* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94344576
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.92987718
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91944573
138TBL1_22424771_ChIP-Seq_293T_Human0.91457091
139* P300_18555785_Chip-Seq_ESCs_Mouse0.90595101
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.90349280
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88892062
142RUNX2_22187159_ChIP-Seq_PCA_Human0.88703322
143* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88400775
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88300076
145NANOG_19829295_ChIP-Seq_ESCs_Human0.86727071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.11933652
2MP0000920_abnormal_myelination4.86714820
3MP0002837_dystrophic_cardiac_calcinosis4.38121810
4MP0005171_absent_coat_pigmentation4.06706841
5MP0004270_analgesia3.95844137
6MP0003950_abnormal_plasma_membrane3.76244845
7MP0003136_yellow_coat_color3.56636374
8MP0005075_abnormal_melanosome_morpholog3.49703852
9MP0004885_abnormal_endolymph3.37275865
10MP0003690_abnormal_glial_cell3.32149450
11MP0000015_abnormal_ear_pigmentation3.25061240
12MP0004215_abnormal_myocardial_fiber3.14002309
13MP0003880_abnormal_central_pattern3.13508643
14MP0004484_altered_response_of3.11407813
15MP0000569_abnormal_digit_pigmentation2.90713516
16MP0003329_amyloid_beta_deposits2.57202016
17MP0005174_abnormal_tail_pigmentation2.54671452
18MP0003646_muscle_fatigue2.53072206
19MP0005330_cardiomyopathy2.52555948
20MP0008775_abnormal_heart_ventricle2.50173929
21MP0003634_abnormal_glial_cell2.45023964
22MP0006138_congestive_heart_failure2.42580097
23MP0000372_irregular_coat_pigmentation2.30389016
24MP0005670_abnormal_white_adipose2.26709226
25MP0002095_abnormal_skin_pigmentation2.23392899
26MP0001486_abnormal_startle_reflex2.23082485
27MP0001485_abnormal_pinna_reflex2.13724870
28MP0002272_abnormal_nervous_system2.13592925
29MP0004142_abnormal_muscle_tone2.04921067
30MP0005409_darkened_coat_color2.02974270
31MP0002972_abnormal_cardiac_muscle2.02873333
32MP0004742_abnormal_vestibular_system2.01589462
33MP0005423_abnormal_somatic_nervous2.00706694
34MP0001529_abnormal_vocalization1.96307789
35MP0002734_abnormal_mechanical_nocicepti1.94708312
36MP0003632_abnormal_nervous_system1.93274706
37MP0002064_seizures1.89451667
38MP0001905_abnormal_dopamine_level1.88549523
39MP0004859_abnormal_synaptic_plasticity1.87884278
40MP0004381_abnormal_hair_follicle1.84856944
41MP0000371_diluted_coat_color1.82853647
42MP0000778_abnormal_nervous_system1.80657207
43MP0009046_muscle_twitch1.74167204
44MP0003828_pulmonary_edema1.70893846
45MP0001324_abnormal_eye_pigmentation1.68136135
46MP0002229_neurodegeneration1.65396348
47MP0001544_abnormal_cardiovascular_syste1.60817377
48MP0005385_cardiovascular_system_phenoty1.60817377
49MP0005408_hypopigmentation1.58427626
50MP0000566_synostosis1.56279214
51MP0005165_increased_susceptibility_to1.54374424
52MP0004043_abnormal_pH_regulation1.51764054
53MP0005620_abnormal_muscle_contractility1.51109178
54MP0003631_nervous_system_phenotype1.47420446
55MP0001299_abnormal_eye_distance/1.46405683
56MP0000383_abnormal_hair_follicle1.44986925
57MP0005451_abnormal_body_composition1.43959807
58MP0003635_abnormal_synaptic_transmissio1.43616542
59MP0000462_abnormal_digestive_system1.41584116
60MP0009745_abnormal_behavioral_response1.39225286
61MP0005551_abnormal_eye_electrophysiolog1.38501433
62MP0004147_increased_porphyrin_level1.36818031
63MP0002075_abnormal_coat/hair_pigmentati1.36382875
64MP0000604_amyloidosis1.35763044
65MP0010678_abnormal_skin_adnexa1.33997790
66MP0008438_abnormal_cutaneous_collagen1.33963693
67MP0008260_abnormal_autophagy1.31543892
68MP0005503_abnormal_tendon_morphology1.29174688
69MP0003633_abnormal_nervous_system1.28801447
70MP0000955_abnormal_spinal_cord1.27301512
71MP0004134_abnormal_chest_morphology1.26323447
72MP0005410_abnormal_fertilization1.24395786
73MP0002067_abnormal_sensory_capabilities1.24084439
74MP0002882_abnormal_neuron_morphology1.20011186
75MP0001970_abnormal_pain_threshold1.19789980
76MP0004085_abnormal_heartbeat1.18839804
77MP0004510_myositis1.17600151
78MP0000747_muscle_weakness1.17253888
79MP0002733_abnormal_thermal_nociception1.16991343
80MP0001440_abnormal_grooming_behavior1.15845562
81MP0004858_abnormal_nervous_system1.15483835
82MP0002269_muscular_atrophy1.14420200
83MP0008569_lethality_at_weaning1.14291349
84MP0004272_abnormal_basement_membrane1.14230578
85MP0005257_abnormal_intraocular_pressure1.12940887
86MP0005386_behavior/neurological_phenoty1.12876800
87MP0004924_abnormal_behavior1.12876800
88MP0005275_abnormal_skin_tensile1.12302683
89MP0010368_abnormal_lymphatic_system1.11707728
90MP0002572_abnormal_emotion/affect_behav1.11692659
91MP0001963_abnormal_hearing_physiology1.10197700
92MP0001968_abnormal_touch/_nociception1.10194749
93MP0004087_abnormal_muscle_fiber1.09719712
94MP0002066_abnormal_motor_capabilities/c1.09166709
95MP0002102_abnormal_ear_morphology1.08013776
96MP0002127_abnormal_cardiovascular_syste1.07550044
97MP0009384_cardiac_valve_regurgitation1.06926688
98MP0001186_pigmentation_phenotype1.06838789
99MP0003806_abnormal_nucleotide_metabolis1.04690211
100MP0002735_abnormal_chemical_nociception1.03353677
101MP0003878_abnormal_ear_physiology1.02959259
102MP0005377_hearing/vestibular/ear_phenot1.02959259
103MP0001661_extended_life_span1.02529731
104MP0002752_abnormal_somatic_nervous1.00142950
105MP0002638_abnormal_pupillary_reflex0.98503455
106MP0002063_abnormal_learning/memory/cond0.96924161
107MP0003195_calcinosis0.94001808
108MP0001984_abnormal_olfaction0.91482655
109MP0000647_abnormal_sebaceous_gland0.89073196
110MP0001346_abnormal_lacrimal_gland0.89037800
111MP0002295_abnormal_pulmonary_circulatio0.85214616
112MP0001986_abnormal_taste_sensitivity0.84614561
113MP0000762_abnormal_tongue_morphology0.83177662
114MP0010630_abnormal_cardiac_muscle0.83100023
115MP0002736_abnormal_nociception_after0.82973718
116MP0000751_myopathy0.81268463
117MP0002106_abnormal_muscle_physiology0.80860707
118MP0005623_abnormal_meninges_morphology0.80608152
119MP0001177_atelectasis0.80549096
120MP0005253_abnormal_eye_physiology0.80349964
121MP0001502_abnormal_circadian_rhythm0.80111410
122MP0000749_muscle_degeneration0.79736373
123MP0003045_fibrosis0.79666285
124MP0002938_white_spotting0.78193207
125MP0005195_abnormal_posterior_eye0.77653365
126MP0004036_abnormal_muscle_relaxation0.77377304
127MP0005058_abnormal_lysosome_morphology0.76112672
128MP0003011_delayed_dark_adaptation0.76034203
129MP0002090_abnormal_vision0.75683191
130MP0004145_abnormal_muscle_electrophysio0.74339265
131MP0005248_abnormal_Harderian_gland0.72890329
132MP0005369_muscle_phenotype0.72674131
133MP0003938_abnormal_ear_development0.71070592
134MP0000026_abnormal_inner_ear0.70253911
135MP0005197_abnormal_uvea_morphology0.70234086
136MP0003656_abnormal_erythrocyte_physiolo0.68910411
137MP0002152_abnormal_brain_morphology0.68335219
138MP0003137_abnormal_impulse_conducting0.68327402
139MP0002108_abnormal_muscle_morphology0.66202344
140MP0000579_abnormal_nail_morphology0.65881128
141MP0003075_altered_response_to0.65333993
142MP0002909_abnormal_adrenal_gland0.64998513
143MP0009250_abnormal_appendicular_skeleto0.62856960
144MP0001879_abnormal_lymphatic_vessel0.62286972
145MP0009780_abnormal_chondrocyte_physiolo0.60397207
146MP0005167_abnormal_blood-brain_barrier0.60325518
147MP0000759_abnormal_skeletal_muscle0.58727051
148MP0004130_abnormal_muscle_cell0.58053969
149MP0000343_altered_response_to0.56733622
150MP0002877_abnormal_melanocyte_morpholog0.55407323
151MP0001501_abnormal_sleep_pattern0.52063666
152MP0002332_abnormal_exercise_endurance0.51725366
153MP0003186_abnormal_redox_activity0.47642657
154MP0000750_abnormal_muscle_regeneration0.46794737
155MP0000013_abnormal_adipose_tissue0.45120970
156MP0000266_abnormal_heart_morphology0.43197876
157MP0010030_abnormal_orbit_morphology0.39986635
158MP0006036_abnormal_mitochondrial_physio0.38102844
159MP0001756_abnormal_urination0.36953257

Predicted human phenotypes

RankGene SetZ-score
1Bundle branch block (HP:0011710)6.60378817
2Sudden death (HP:0001699)6.40665543
3Neurofibrillary tangles (HP:0002185)6.11036755
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.08274230
5Degeneration of the lateral corticospinal tracts (HP:0002314)6.08274230
6Atrial fibrillation (HP:0005110)5.19159818
7Syncope (HP:0001279)5.06977823
8Hypoplasia of the fovea (HP:0007750)4.86207205
9Aplasia/Hypoplasia of the fovea (HP:0008060)4.86207205
10Peripheral hypomyelination (HP:0007182)4.74541088
11Insidious onset (HP:0003587)4.73984613
12Termporal pattern (HP:0011008)4.73984613
13Primary atrial arrhythmia (HP:0001692)4.70701905
14Parakeratosis (HP:0001036)4.69076245
15Abnormality of the corticospinal tract (HP:0002492)4.65922024
16Ocular albinism (HP:0001107)4.59648025
17Right ventricular cardiomyopathy (HP:0011663)4.56459795
18Supraventricular tachycardia (HP:0004755)4.51410062
19Ventricular tachycardia (HP:0004756)4.47087521
20Supraventricular arrhythmia (HP:0005115)4.37541748
21Abnormality of the fovea (HP:0000493)4.37444491
22Cerebral inclusion bodies (HP:0100314)4.35735562
23Aplasia/Hypoplasia of the macula (HP:0008059)4.34495892
24Iris hypopigmentation (HP:0007730)4.27672685
25Sensory axonal neuropathy (HP:0003390)4.26813836
26Onion bulb formation (HP:0003383)4.20724870
27Aplasia/Hypoplasia affecting the retina (HP:0008061)4.05259318
28Distal lower limb muscle weakness (HP:0009053)3.96065415
29Ventricular arrhythmia (HP:0004308)3.94101680
30Abnormality of the calf musculature (HP:0001430)3.81084692
31Muscle fiber splitting (HP:0003555)3.79730721
32Heart block (HP:0012722)3.77317123
33Lipoatrophy (HP:0100578)3.76871570
34Supranuclear gaze palsy (HP:0000605)3.66417127
35Abnormal atrioventricular conduction (HP:0005150)3.59598836
36Segmental peripheral demyelination/remyelination (HP:0003481)3.55663309
37Albinism (HP:0001022)3.54428058
38Dilated cardiomyopathy (HP:0001644)3.49920847
39Asymmetric septal hypertrophy (HP:0001670)3.49271783
40Abnormal auditory evoked potentials (HP:0006958)3.41195447
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.33793635
42Generalized hypopigmentation (HP:0007513)3.32187024
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.19345050
44Spastic gait (HP:0002064)3.15892207
45Alacrima (HP:0000522)3.11896107
46Pheochromocytoma (HP:0002666)3.08210242
47Upper limb muscle weakness (HP:0003484)3.05570888
48Aplasia of the phalanges of the hand (HP:0009802)3.04829835
49Aplasia involving bones of the extremities (HP:0009825)3.04829835
50Aplasia involving bones of the upper limbs (HP:0009823)3.04829835
51Heterochromia iridis (HP:0001100)3.03990314
52EMG: myopathic abnormalities (HP:0003458)3.01296727
53Hypopigmentation of the fundus (HP:0007894)2.97378848
54Ulnar claw (HP:0001178)2.89293868
55Intention tremor (HP:0002080)2.87702318
56Akinesia (HP:0002304)2.84020597
57Palpitations (HP:0001962)2.83555140
58Myokymia (HP:0002411)2.81874159
59Slow saccadic eye movements (HP:0000514)2.78989662
60Action tremor (HP:0002345)2.78525488
61Anteriorly placed anus (HP:0001545)2.76604243
62White forelock (HP:0002211)2.73672011
63Cerebral hypomyelination (HP:0006808)2.73215164
64Dysmetria (HP:0001310)2.73117689
65Ventricular fibrillation (HP:0001663)2.73024611
66Subaortic stenosis (HP:0001682)2.71933160
67Abnormality of the left ventricular outflow tract (HP:0011103)2.71933160
68Neuroendocrine neoplasm (HP:0100634)2.70462825
69Clumsiness (HP:0002312)2.70366401
70Premature skin wrinkling (HP:0100678)2.63043554
71Patchy hypopigmentation of hair (HP:0011365)2.59681406
72Atrioventricular block (HP:0001678)2.59199340
73Cerebral hemorrhage (HP:0001342)2.53767105
74Generalized hypopigmentation of hair (HP:0011358)2.51732967
75Megalencephaly (HP:0001355)2.50404528
76Absent septum pellucidum (HP:0001331)2.50274340
77Hypoplasia of the iris (HP:0007676)2.49780600
78Congenital ichthyosiform erythroderma (HP:0007431)2.48221024
79Ankle clonus (HP:0011448)2.47627848
80Retinal dysplasia (HP:0007973)2.46435967
81Tongue fasciculations (HP:0001308)2.46201188
82Foot dorsiflexor weakness (HP:0009027)2.45863057
83Steppage gait (HP:0003376)2.45019288
84Blue irides (HP:0000635)2.44515185
85Coronal craniosynostosis (HP:0004440)2.44459605
86Prolonged QT interval (HP:0001657)2.42709512
87Scanning speech (HP:0002168)2.42031200
88Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.39388505
89Premature graying of hair (HP:0002216)2.38148697
90Decreased motor nerve conduction velocity (HP:0003431)2.36000310
91Infantile muscular hypotonia (HP:0008947)2.33629945
92Left ventricular hypertrophy (HP:0001712)2.31500137
93Decreased lacrimation (HP:0000633)2.30409932
94Spastic paraparesis (HP:0002313)2.30177267
95Morphological abnormality of the inner ear (HP:0011390)2.29684117
96Leukodystrophy (HP:0002415)2.29431111
97Hammertoe (HP:0001765)2.28910128
98Abnormal pupillary function (HP:0007686)2.28543304
99Hypoplastic pelvis (HP:0008839)2.28124226
100Calf muscle hypertrophy (HP:0008981)2.25491344
101EMG: neuropathic changes (HP:0003445)2.21620539
102J-shaped sella turcica (HP:0002680)2.20649968
103Abnormality of the foot musculature (HP:0001436)2.20020076
104Autoamputation (HP:0001218)2.20017154
105Increased serum pyruvate (HP:0003542)2.19538596
106Abnormality of glycolysis (HP:0004366)2.19538596
107Abnormal EKG (HP:0003115)2.15341739
108Increased circulating renin level (HP:0000848)2.15118232
109Muscle fibrillation (HP:0010546)2.14740453
110Thickened helices (HP:0000391)2.11127692
111Methylmalonic acidemia (HP:0002912)2.10849780
112Impaired proprioception (HP:0010831)2.07788990
113Lower limb muscle weakness (HP:0007340)2.07341233
114Macular degeneration (HP:0000608)2.07107282
115Abnormality of the septum pellucidum (HP:0007375)2.05983483
116Split foot (HP:0001839)2.03590176
117Hypomagnesemia (HP:0002917)2.02390990
118Peripheral demyelination (HP:0011096)2.02188921
119Hypophosphatemic rickets (HP:0004912)2.02136434
120Synostosis involving the elbow (HP:0003938)2.01578174
121Humeroradial synostosis (HP:0003041)2.01578174
122Difficulty running (HP:0009046)2.00457974
123Paraparesis (HP:0002385)1.99818416
124CNS hypomyelination (HP:0003429)1.99524075
125Abnormality of binocular vision (HP:0011514)1.96585422
126Diplopia (HP:0000651)1.96585422
127Areflexia of lower limbs (HP:0002522)1.95578866
128Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95567285
129Spastic tetraparesis (HP:0001285)1.95541550
130Gowers sign (HP:0003391)1.93881307
131Hemiparesis (HP:0001269)1.93657615
132Difficulty walking (HP:0002355)1.91668232
133Ragged-red muscle fibers (HP:0003200)1.91617459
134Freckling (HP:0001480)1.91369071
135Palmoplantar keratoderma (HP:0000982)1.90440016
136Stridor (HP:0010307)1.90138425
137Neck muscle weakness (HP:0000467)1.89402350
138Adrenal hypoplasia (HP:0000835)1.89180723
139Focal motor seizures (HP:0011153)1.88006425
140Scapular winging (HP:0003691)1.87740843
141Muscle hypertrophy of the lower extremities (HP:0008968)1.86435896
142Distal sensory impairment (HP:0002936)1.84940176
143Sudden cardiac death (HP:0001645)1.84510376
144Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84153047
145Congenital stationary night blindness (HP:0007642)1.83785360
146Dyschromatopsia (HP:0007641)1.83179838
147Congenital sensorineural hearing impairment (HP:0008527)1.82180002
148Bradycardia (HP:0001662)1.81412816
149Metabolic alkalosis (HP:0200114)1.81376748
150Abnormality of the middle phalanges of the toes (HP:0010183)1.81328476
151Axonal loss (HP:0003447)1.76647109
152Proximal amyotrophy (HP:0007126)1.74440014
153Diminished movement (HP:0002374)1.73015494
154Hyporeflexia of lower limbs (HP:0002600)1.69512225
155Generalized myoclonic seizures (HP:0002123)1.69333030
156Myelomeningocele (HP:0002475)1.68918288
157Relative macrocephaly (HP:0004482)1.68341315
158Urinary urgency (HP:0000012)1.65531108
159Bell-shaped thorax (HP:0001591)1.65487649
160Postural tremor (HP:0002174)1.64360515
161Exercise-induced muscle cramps (HP:0003710)1.62281405
162Clonus (HP:0002169)1.61097117
163Hepatosplenomegaly (HP:0001433)1.60715795
164Mixed hearing impairment (HP:0000410)1.60414104
165Polydipsia (HP:0001959)1.58638173
166Abnormal drinking behavior (HP:0030082)1.58638173
167Hand muscle atrophy (HP:0009130)1.57687048
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54836895
169Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.50920635
170Increased connective tissue (HP:0009025)1.50429649
171Horizontal nystagmus (HP:0000666)1.50337581
172Increased CSF protein (HP:0002922)1.46164701
173Decreased circulating renin level (HP:0003351)1.45895265
174Cutaneous melanoma (HP:0012056)1.45427386
175Complement deficiency (HP:0004431)1.45129749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.18461297
2OXSR14.39341514
3TRIM284.26001716
4MYLK4.24003706
5MAP3K33.83092912
6FRK3.77055111
7TNIK3.62852766
8EPHB13.55406866
9SIK33.37665826
10MET2.71027471
11FGFR22.46900343
12WNK42.46618587
13CDK192.31977140
14WNK12.28658936
15PKN12.18267781
16BCR2.09028398
17PDK22.08048933
18MAPKAPK52.07881213
19LIMK12.04399944
20TTN2.03178794
21PBK1.93904533
22NTRK11.92996722
23ACVR1B1.81613338
24NEK61.76481593
25MAP4K21.66205163
26ERBB31.65655848
27MST41.65289213
28PAK61.57832661
29CSNK1A1L1.49896707
30CASK1.49083016
31CSNK1G31.44632714
32BLK1.41999822
33MUSK1.41665537
34FER1.40405802
35UHMK11.36745329
36CAMK2B1.35958913
37PNCK1.33831059
38ROCK21.33105589
39ICK1.29106908
40CAMK2D1.26431597
41EPHA41.24641898
42SGK4941.22023497
43SGK2231.22023497
44TGFBR21.22019525
45MARK31.20491497
46CSNK1G11.18595277
47IRAK21.16106714
48NTRK31.12442227
49CSNK1G21.12353956
50EIF2AK31.11548196
51FGR1.11223924
52PHKG11.09890755
53PHKG21.09890755
54MARK21.06885705
55PLK21.03845899
56DAPK31.03244948
57PRPF4B1.02469128
58ROCK11.01510300
59PAK31.01014832
60PIK3CA1.00456442
61EPHA31.00349572
62MKNK20.96483333
63CAMK2G0.92290919
64CDK50.90765967
65MAP3K40.89814231
66MST1R0.89686622
67MAP3K60.85919898
68GRK10.85801067
69PTK2B0.85047368
70MKNK10.84828465
71CDK140.84621793
72CAMK1G0.84212128
73PIK3CG0.82245953
74TYRO30.81291494
75CLK10.80664041
76CDK150.79978788
77ERBB40.78643101
78KSR10.78223631
79MARK10.77463798
80CAMK2A0.76591100
81PRKAA20.76284010
82PRKCQ0.74299963
83TIE10.74083301
84CDK180.73900740
85STK30.73790945
86BMPR1B0.73568885
87DMPK0.72620227
88TRPM70.72463910
89PRKD10.71232710
90PRKCE0.70928042
91PDPK10.70297064
92CDK11A0.68985972
93WEE10.66933943
94STK38L0.66879357
95CDC42BPA0.66200702
96MAPK150.66087923
97NTRK20.65362502
98MAPKAPK30.63911160
99BMX0.63374024
100DDR20.61211513
101PRKCH0.59165606
102FYN0.58882417
103MAPK40.58627241
104CAMK40.58470646
105INSRR0.57914610
106PRKD30.57501237
107NLK0.56628238
108IRAK10.55681372
109CAMK10.55196926
110GSK3A0.55049339
111GRK50.53658709
112DYRK20.52439300
113MINK10.50387645
114MAP2K10.49819699
115ADRBK10.49361393
116PRKAA10.48045807
117GRK70.47988787
118PRKG10.47574709
119WNK30.44690191
120PRKACG0.44298959
121AKT20.43474059
122RPS6KA50.43227000
123PRKACB0.42858943
124CSNK1D0.42408343
125MAPK130.42373173
126MAPK70.41871726
127STK40.41375697
128CSNK1A10.40899015
129CAMK1D0.40456934
130MAP3K50.40333026
131KSR20.39603625
132RET0.39354609
133PDGFRB0.39111026
134ADRBK20.38161588
135LATS10.37577170
136DYRK1A0.36994597
137FGFR10.36901858
138NEK90.36843913
139AKT30.34979553
140MAP3K70.34841313
141PDK10.34415839
142MAPK120.34361713
143PINK10.32713386
144ABL10.31928947
145STK110.31750261
146PAK10.30993192
147MAP2K70.30920447
148ARAF0.30156118
149PRKACA0.30002601
150LMTK20.29273905
151MAP2K20.28501365
152TESK20.28164020
153MAP3K130.27805449
154OBSCN0.27602973
155SGK10.25780883

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.82512639
2Steroid biosynthesis_Homo sapiens_hsa001004.60093887
3Fatty acid elongation_Homo sapiens_hsa000624.08191355
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.79298762
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79814592
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65584375
7Ether lipid metabolism_Homo sapiens_hsa005652.60128519
8Nitrogen metabolism_Homo sapiens_hsa009102.58378776
9Sulfur metabolism_Homo sapiens_hsa009202.26508981
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85278907
11Sphingolipid metabolism_Homo sapiens_hsa006001.82446716
12Butanoate metabolism_Homo sapiens_hsa006501.64948317
13Axon guidance_Homo sapiens_hsa043601.64665915
14beta-Alanine metabolism_Homo sapiens_hsa004101.59995202
15cGMP-PKG signaling pathway_Homo sapiens_hsa040221.57236083
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.47401642
17Calcium signaling pathway_Homo sapiens_hsa040201.46894534
18Histidine metabolism_Homo sapiens_hsa003401.46713579
19Linoleic acid metabolism_Homo sapiens_hsa005911.43475843
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.41327205
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40321588
22Fatty acid biosynthesis_Homo sapiens_hsa000611.30188024
23Oxidative phosphorylation_Homo sapiens_hsa001901.28510364
24Glutamatergic synapse_Homo sapiens_hsa047241.25840234
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24601979
26Fatty acid metabolism_Homo sapiens_hsa012121.23666866
27Circadian rhythm_Homo sapiens_hsa047101.22232933
28ABC transporters_Homo sapiens_hsa020101.22186833
29GABAergic synapse_Homo sapiens_hsa047271.19278487
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18316688
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16384599
32Phototransduction_Homo sapiens_hsa047441.14208953
33PPAR signaling pathway_Homo sapiens_hsa033201.14118786
34Dorso-ventral axis formation_Homo sapiens_hsa043201.13562365
35Fatty acid degradation_Homo sapiens_hsa000711.12066471
36Serotonergic synapse_Homo sapiens_hsa047261.11252617
37Arginine and proline metabolism_Homo sapiens_hsa003301.10581146
38Complement and coagulation cascades_Homo sapiens_hsa046101.07282512
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06510750
40Oxytocin signaling pathway_Homo sapiens_hsa049211.06490288
41Protein export_Homo sapiens_hsa030601.05473570
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03608479
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02656183
44Renal cell carcinoma_Homo sapiens_hsa052111.00440379
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99492188
46Amphetamine addiction_Homo sapiens_hsa050310.98684865
47Propanoate metabolism_Homo sapiens_hsa006400.94478600
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93024119
49Morphine addiction_Homo sapiens_hsa050320.92043141
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91644303
51Alzheimers disease_Homo sapiens_hsa050100.88998575
52Phenylalanine metabolism_Homo sapiens_hsa003600.88944998
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88865796
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88561509
55Long-term depression_Homo sapiens_hsa047300.87951110
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87524572
57Salivary secretion_Homo sapiens_hsa049700.86443578
58ECM-receptor interaction_Homo sapiens_hsa045120.85678717
59Tight junction_Homo sapiens_hsa045300.84657290
60Focal adhesion_Homo sapiens_hsa045100.84201766
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.82280519
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.81908828
63Tryptophan metabolism_Homo sapiens_hsa003800.81797249
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81778460
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81760241
66Olfactory transduction_Homo sapiens_hsa047400.81702102
67Gastric acid secretion_Homo sapiens_hsa049710.79658576
68Parkinsons disease_Homo sapiens_hsa050120.79134713
69Vibrio cholerae infection_Homo sapiens_hsa051100.78788255
70Cocaine addiction_Homo sapiens_hsa050300.78721161
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.78438601
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78285588
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77927236
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.76751218
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76072261
76Ras signaling pathway_Homo sapiens_hsa040140.75217661
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74523503
78Ovarian steroidogenesis_Homo sapiens_hsa049130.74480979
79Circadian entrainment_Homo sapiens_hsa047130.74200409
80Lysosome_Homo sapiens_hsa041420.73650268
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73360333
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72851369
83ErbB signaling pathway_Homo sapiens_hsa040120.72713508
84Mineral absorption_Homo sapiens_hsa049780.70113355
85Vitamin digestion and absorption_Homo sapiens_hsa049770.67259663
86Collecting duct acid secretion_Homo sapiens_hsa049660.67181687
87Cardiac muscle contraction_Homo sapiens_hsa042600.65658273
88Arachidonic acid metabolism_Homo sapiens_hsa005900.64840535
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.63315802
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62630374
91Malaria_Homo sapiens_hsa051440.60882358
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60370271
93Tyrosine metabolism_Homo sapiens_hsa003500.60105936
94Rheumatoid arthritis_Homo sapiens_hsa053230.59469703
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58979303
96Pancreatic secretion_Homo sapiens_hsa049720.57530944
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.56930915
98Retinol metabolism_Homo sapiens_hsa008300.54924121
99Lysine degradation_Homo sapiens_hsa003100.54894307
100Melanoma_Homo sapiens_hsa052180.54655516
101Autoimmune thyroid disease_Homo sapiens_hsa053200.54283319
102Endocytosis_Homo sapiens_hsa041440.53114111
103Cholinergic synapse_Homo sapiens_hsa047250.52460824
104Dilated cardiomyopathy_Homo sapiens_hsa054140.52305539
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51953014
106Glutathione metabolism_Homo sapiens_hsa004800.51777067
107Dopaminergic synapse_Homo sapiens_hsa047280.51160455
108Renin secretion_Homo sapiens_hsa049240.50405967
109Thyroid hormone synthesis_Homo sapiens_hsa049180.49435108
110Regulation of autophagy_Homo sapiens_hsa041400.49127265
111Glucagon signaling pathway_Homo sapiens_hsa049220.48710382
112Nicotine addiction_Homo sapiens_hsa050330.48286558
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48114697
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47897633
115Gap junction_Homo sapiens_hsa045400.47411514
116Hedgehog signaling pathway_Homo sapiens_hsa043400.46812642
117Peroxisome_Homo sapiens_hsa041460.45880784
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.45684256
119Chemical carcinogenesis_Homo sapiens_hsa052040.42860715
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42076329
121Synaptic vesicle cycle_Homo sapiens_hsa047210.41277073
122Phagosome_Homo sapiens_hsa041450.40666336
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40167879
124Insulin resistance_Homo sapiens_hsa049310.40084918
125Glycerolipid metabolism_Homo sapiens_hsa005610.39776864
126Melanogenesis_Homo sapiens_hsa049160.39001670
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38852308
128Choline metabolism in cancer_Homo sapiens_hsa052310.38552810
129Protein digestion and absorption_Homo sapiens_hsa049740.37926053
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37492583
131Long-term potentiation_Homo sapiens_hsa047200.37460957
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36498463
133Pyruvate metabolism_Homo sapiens_hsa006200.35286031
134Insulin secretion_Homo sapiens_hsa049110.34213508
135Bile secretion_Homo sapiens_hsa049760.33852200
136Metabolic pathways_Homo sapiens_hsa011000.32269020
137cAMP signaling pathway_Homo sapiens_hsa040240.31491603
138Taste transduction_Homo sapiens_hsa047420.31489924
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31131963

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