CDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.05861746
2cardiac myofibril assembly (GO:0055003)4.00070594
3retinal ganglion cell axon guidance (GO:0031290)3.80073153
4axon extension involved in axon guidance (GO:0048846)3.74858866
5neuron projection extension involved in neuron projection guidance (GO:1902284)3.74858866
6pyrimidine nucleobase catabolic process (GO:0006208)3.74715053
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.66874073
8cell communication by electrical coupling (GO:0010644)3.66592172
9layer formation in cerebral cortex (GO:0021819)3.49795642
10sarcomere organization (GO:0045214)3.46832536
11negative regulation of potassium ion transmembrane transport (GO:1901380)3.45748319
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45223300
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.43978431
14axonal fasciculation (GO:0007413)3.43571354
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.38617115
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.36900267
17neuron recognition (GO:0008038)3.36187225
18paraxial mesoderm development (GO:0048339)3.35881502
19neuron cell-cell adhesion (GO:0007158)3.31146477
20negative chemotaxis (GO:0050919)3.17722896
21olfactory bulb development (GO:0021772)3.17104181
22myofibril assembly (GO:0030239)3.16054577
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.13917245
24cell communication involved in cardiac conduction (GO:0086065)3.11816241
25regulation of membrane repolarization (GO:0060306)3.06609314
26plasma membrane repair (GO:0001778)3.00597972
27nonmotile primary cilium assembly (GO:0035058)2.99675771
28dendritic spine morphogenesis (GO:0060997)2.99536178
29somite development (GO:0061053)2.98972718
30intraciliary transport (GO:0042073)2.98911410
31dendrite morphogenesis (GO:0048813)2.95741149
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.95732763
33cardiac muscle contraction (GO:0060048)2.89387953
34spinal cord development (GO:0021510)2.88971053
35regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87859515
36appendage development (GO:0048736)2.87158957
37limb development (GO:0060173)2.87158957
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85458716
39vocalization behavior (GO:0071625)2.84884783
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.84603156
41nucleobase catabolic process (GO:0046113)2.82382334
42adult heart development (GO:0007512)2.80436505
43cell migration in hindbrain (GO:0021535)2.79917342
44establishment of nucleus localization (GO:0040023)2.77158505
45regulation of sarcomere organization (GO:0060297)2.76767381
46ventricular cardiac muscle cell action potential (GO:0086005)2.75773794
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74293291
48negative regulation of oligodendrocyte differentiation (GO:0048715)2.74042516
49notochord development (GO:0030903)2.73584380
50regulation of development, heterochronic (GO:0040034)2.71400230
51regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69725864
52* calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69241884
53atrial septum morphogenesis (GO:0060413)2.68910577
54cardiac muscle cell development (GO:0055013)2.68561456
55lens morphogenesis in camera-type eye (GO:0002089)2.67106532
56regulation of actin filament-based movement (GO:1903115)2.65310851
57central nervous system projection neuron axonogenesis (GO:0021952)2.63911923
58postsynaptic membrane organization (GO:0001941)2.63644138
59ephrin receptor signaling pathway (GO:0048013)2.63355004
60embryonic foregut morphogenesis (GO:0048617)2.63129500
61cerebral cortex cell migration (GO:0021795)2.61726989
62axon extension (GO:0048675)2.61720219
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61540101
64establishment of mitochondrion localization (GO:0051654)2.61021249
65short-term memory (GO:0007614)2.60221175
66regulation of axon extension involved in axon guidance (GO:0048841)2.59862837
67otic vesicle formation (GO:0030916)2.58187097
68detection of calcium ion (GO:0005513)2.56810109
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56358251
70presynaptic membrane assembly (GO:0097105)2.56217985
71cardiac chamber formation (GO:0003207)2.55534088
72cardiac cell development (GO:0055006)2.55265013
73cell proliferation in forebrain (GO:0021846)2.54388631
74lens fiber cell development (GO:0070307)2.54379695
75convergent extension (GO:0060026)2.54260270
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53998515
77regulation of axon guidance (GO:1902667)2.52818786
78cerebral cortex radially oriented cell migration (GO:0021799)2.50803159
79sequestering of actin monomers (GO:0042989)2.50530536
80negative regulation of protein localization to cell surface (GO:2000009)2.50168924
81negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49782029
82actomyosin structure organization (GO:0031032)2.49701861
83transmission of nerve impulse (GO:0019226)2.49305618
84neuron fate determination (GO:0048664)2.48780016
85cardiac muscle hypertrophy (GO:0003300)2.48489412
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.48008777
87regulation of glutamate receptor signaling pathway (GO:1900449)2.47536561
88establishment of tissue polarity (GO:0007164)2.47479909
89establishment of planar polarity (GO:0001736)2.47479909
90regulation of cell communication by electrical coupling (GO:0010649)2.46463529
91regulation of synapse structural plasticity (GO:0051823)2.44539845
92synapse assembly (GO:0007416)2.43936499
93positive regulation of synapse assembly (GO:0051965)2.42405346
94dorsal/ventral axis specification (GO:0009950)2.42054438
95protein localization to synapse (GO:0035418)2.41341549
96cellular ketone body metabolic process (GO:0046950)2.40562500
97innervation (GO:0060384)2.40432994
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40185999
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.40168401
100heart trabecula formation (GO:0060347)2.38877316
101locomotory exploration behavior (GO:0035641)2.38597871
102regulation of dendritic spine morphogenesis (GO:0061001)2.36355341
103spinal cord association neuron differentiation (GO:0021527)2.36114929
104neuron migration (GO:0001764)2.35117624
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.34696046
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33244749
107striated muscle hypertrophy (GO:0014897)2.33049501
108epithelial cilium movement (GO:0003351)2.32989984
109midbrain development (GO:0030901)2.32972726
110forebrain neuron differentiation (GO:0021879)2.32434680
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.32139675
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.32071588
113smoothened signaling pathway (GO:0007224)2.31425902
114glial cell proliferation (GO:0014009)2.31324939
115limb bud formation (GO:0060174)2.30233498
116apical protein localization (GO:0045176)2.30077078
117regulation of potassium ion transmembrane transport (GO:1901379)2.29937600
118artery development (GO:0060840)2.29562228
119cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28459711
120cardiac ventricle formation (GO:0003211)2.28456035
121central nervous system neuron axonogenesis (GO:0021955)2.27572180
122positive regulation of neuroblast proliferation (GO:0002052)2.27521379
123regulation of cardiac muscle cell contraction (GO:0086004)2.27263923
124thalamus development (GO:0021794)2.27096455
125negative regulation of axon guidance (GO:1902668)2.26293989
126camera-type eye morphogenesis (GO:0048593)2.24766760
127negative regulation of glial cell differentiation (GO:0045686)2.24706242
128regulation of short-term neuronal synaptic plasticity (GO:0048172)2.24667011
129hindbrain development (GO:0030902)2.24623738
130ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.24174299
131cellular response to cholesterol (GO:0071397)2.24172502
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23814867
133regulation of cardiac muscle contraction (GO:0055117)2.23742040
134presynaptic membrane organization (GO:0097090)2.23645448
135gastrulation with mouth forming second (GO:0001702)2.22823545
136lateral sprouting from an epithelium (GO:0060601)2.22711427
137morphogenesis of an epithelial sheet (GO:0002011)2.22640925
138cerebellar granule cell differentiation (GO:0021707)2.22631541
139neurotransmitter-gated ion channel clustering (GO:0072578)2.22595803
140regulation of cardioblast differentiation (GO:0051890)2.22582849
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21894428
142hippocampus development (GO:0021766)2.21882272
143regulation of establishment of planar polarity (GO:0090175)2.21718093
144cardiac muscle tissue morphogenesis (GO:0055008)2.21709145
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.21645191
146cell migration involved in sprouting angiogenesis (GO:0002042)2.21603104
147ganglion development (GO:0061548)2.21472426
148regulation of synapse assembly (GO:0051963)2.21412838
149nucleus localization (GO:0051647)2.21378682
150cardiac muscle cell action potential (GO:0086001)2.21041313
151regulation of potassium ion transmembrane transporter activity (GO:1901016)2.20846491
152neuron projection extension (GO:1990138)2.20799360
153regulation of striated muscle contraction (GO:0006942)2.20372280
154regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.20206848
155negative regulation of axon extension (GO:0030517)2.19559135
156membrane repolarization (GO:0086009)2.19179708
157positive regulation of gastrulation (GO:2000543)2.18824965
158regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.18572248
159regulation of timing of cell differentiation (GO:0048505)2.18484584
160asymmetric protein localization (GO:0008105)2.18347727
161sarcoplasmic reticulum calcium ion transport (GO:0070296)2.18066052
162auditory behavior (GO:0031223)2.17321019
163positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.16934740
164regulation of heart rate by cardiac conduction (GO:0086091)2.15732249
165negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.15305879
166regulation of heart rate (GO:0002027)2.15144554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73503637
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71022159
3GBX2_23144817_ChIP-Seq_PC3_Human2.64393918
4* EZH2_27304074_Chip-Seq_ESCs_Mouse2.60406734
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54705598
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54446091
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46477862
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46477862
9* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38141480
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32378029
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29706703
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.28923829
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26190804
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18196246
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17859576
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06844007
17* EP300_21415370_ChIP-Seq_HL-1_Mouse2.06047469
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02520183
19* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97213880
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87719365
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86241397
22* CBX2_27304074_Chip-Seq_ESCs_Mouse1.84629883
23* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81176600
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81106550
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80252917
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75822825
27EWS_26573619_Chip-Seq_HEK293_Human1.73456100
28* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72373595
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71677598
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71398807
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.70224691
32DROSHA_22980978_ChIP-Seq_HELA_Human1.67013646
33AR_21572438_ChIP-Seq_LNCaP_Human1.61999135
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61855929
35ZNF274_21170338_ChIP-Seq_K562_Hela1.61669470
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60439422
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60378039
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56218662
39* REST_21632747_ChIP-Seq_MESCs_Mouse1.54296493
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53036528
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50204841
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49600684
43* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48423489
44* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48156107
45* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46403984
46SMAD4_21799915_ChIP-Seq_A2780_Human1.43303551
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43237763
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40538529
49* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39482230
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38094733
51* TAF15_26573619_Chip-Seq_HEK293_Human1.36704761
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.35912499
53TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35632471
54TBX3_20139965_ChIP-Seq_ESCs_Mouse1.35146620
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33616564
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33058107
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32959001
58P300_19829295_ChIP-Seq_ESCs_Human1.32457793
59SOX9_26525672_Chip-Seq_HEART_Mouse1.30157181
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.28430331
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28394481
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27789740
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.27586070
64* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26775867
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26507237
66* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26109088
67* SOX2_16153702_ChIP-ChIP_HESCs_Human1.25366816
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24378336
69* REST_18959480_ChIP-ChIP_MESCs_Mouse1.24152098
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23721942
71* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22884149
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.22501369
73IGF1R_20145208_ChIP-Seq_DFB_Human1.21154284
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.20810782
75* ISL1_27105846_Chip-Seq_CPCs_Mouse1.20458466
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20440366
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19438030
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18795054
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17861442
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17759180
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17575718
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17338226
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16389394
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16363654
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.14935993
86* AR_19668381_ChIP-Seq_PC3_Human1.14049044
87BCAT_22108803_ChIP-Seq_LS180_Human1.12856984
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12479291
89AHR_22903824_ChIP-Seq_MCF-7_Human1.12324250
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.11283057
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10595931
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09085492
93VDR_22108803_ChIP-Seq_LS180_Human1.09005021
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08658733
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08039642
96FUS_26573619_Chip-Seq_HEK293_Human1.07733491
97* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07401282
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07078055
99TP53_18474530_ChIP-ChIP_U2OS_Human1.06887943
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.06838871
101STAT3_23295773_ChIP-Seq_U87_Human1.05952163
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05829664
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.05305234
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05304272
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04320061
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.03290280
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00861928
108TP53_16413492_ChIP-PET_HCT116_Human1.00386973
109IRF1_19129219_ChIP-ChIP_H3396_Human1.00076070
110AR_25329375_ChIP-Seq_VCAP_Human0.99836582
111* NANOG_16153702_ChIP-ChIP_HESCs_Human0.99736443
112RNF2_27304074_Chip-Seq_NSC_Mouse0.99718592
113* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99460266
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96785309
115* RUNX2_22187159_ChIP-Seq_PCA_Human0.95843572
116* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94309414
117* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94309414
118* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94142453
119* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94142453
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94029782
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93949750
122* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91937656
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91823066
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91516021
125* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90364571
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90335838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.91573509
2MP0004215_abnormal_myocardial_fiber2.74445313
3MP0004084_abnormal_cardiac_muscle2.70986995
4MP0000751_myopathy2.70641584
5MP0006292_abnormal_olfactory_placode2.70543202
6MP0000566_synostosis2.53054525
7MP0003880_abnormal_central_pattern2.26066657
8MP0004859_abnormal_synaptic_plasticity2.24178918
9MP0000778_abnormal_nervous_system2.19795993
10* MP0003137_abnormal_impulse_conducting2.09295569
11MP0001293_anophthalmia2.08143889
12MP0009780_abnormal_chondrocyte_physiolo2.06795044
13MP0005499_abnormal_olfactory_system2.06391159
14MP0005394_taste/olfaction_phenotype2.06391159
15MP0002938_white_spotting1.99177128
16MP0004270_analgesia1.98881327
17MP0008789_abnormal_olfactory_epithelium1.93792511
18MP0003136_yellow_coat_color1.93514816
19MP0004036_abnormal_muscle_relaxation1.85707181
20MP0003635_abnormal_synaptic_transmissio1.83380531
21MP0005330_cardiomyopathy1.81359404
22MP0004133_heterotaxia1.74266673
23MP0003122_maternal_imprinting1.70663938
24MP0003890_abnormal_embryonic-extraembry1.66474354
25MP0002102_abnormal_ear_morphology1.64573549
26MP0005623_abnormal_meninges_morphology1.63216567
27* MP0002972_abnormal_cardiac_muscle1.62518246
28MP0002234_abnormal_pharynx_morphology1.62490664
29* MP0004085_abnormal_heartbeat1.62245192
30MP0004233_abnormal_muscle_weight1.59876618
31MP0002063_abnormal_learning/memory/cond1.56499457
32MP0003121_genomic_imprinting1.54352747
33MP0002653_abnormal_ependyma_morphology1.54197748
34MP0005423_abnormal_somatic_nervous1.48016666
35* MP0005620_abnormal_muscle_contractility1.44152437
36MP0001286_abnormal_eye_development1.44096217
37MP0003938_abnormal_ear_development1.44055887
38MP0006138_congestive_heart_failure1.43167853
39MP0002751_abnormal_autonomic_nervous1.39942449
40MP0000749_muscle_degeneration1.37956457
41MP0001486_abnormal_startle_reflex1.37860225
42MP0003385_abnormal_body_wall1.35218637
43* MP0004087_abnormal_muscle_fiber1.35157024
44MP0006276_abnormal_autonomic_nervous1.34622290
45MP0002184_abnormal_innervation1.32805363
46MP0009384_cardiac_valve_regurgitation1.31526915
47MP0009745_abnormal_behavioral_response1.29955315
48MP0004145_abnormal_muscle_electrophysio1.29368449
49MP0002092_abnormal_eye_morphology1.27373673
50MP0005171_absent_coat_pigmentation1.27078201
51MP0002572_abnormal_emotion/affect_behav1.26868577
52MP0005187_abnormal_penis_morphology1.24920598
53MP0002734_abnormal_mechanical_nocicepti1.23410147
54MP0008775_abnormal_heart_ventricle1.23357188
55MP0003283_abnormal_digestive_organ1.22729277
56MP0003646_muscle_fatigue1.22069574
57MP0002822_catalepsy1.21996670
58MP0001299_abnormal_eye_distance/1.21417680
59MP0004858_abnormal_nervous_system1.19077661
60MP0002064_seizures1.18431462
61MP0003567_abnormal_fetal_cardiomyocyte1.17346923
62MP0005646_abnormal_pituitary_gland1.17065802
63MP0000026_abnormal_inner_ear1.15923409
64MP0010030_abnormal_orbit_morphology1.15644805
65MP0005391_vision/eye_phenotype1.15111618
66MP0002282_abnormal_trachea_morphology1.13729969
67MP0002638_abnormal_pupillary_reflex1.11216932
68* MP0005385_cardiovascular_system_phenoty1.10981973
69* MP0001544_abnormal_cardiovascular_syste1.10981973
70* MP0010630_abnormal_cardiac_muscle1.10619883
71MP0002736_abnormal_nociception_after1.10561955
72MP0000955_abnormal_spinal_cord1.09523759
73MP0005248_abnormal_Harderian_gland1.09290263
74MP0003329_amyloid_beta_deposits1.08815274
75MP0001984_abnormal_olfaction1.08645850
76MP0001440_abnormal_grooming_behavior1.06244291
77MP0004272_abnormal_basement_membrane1.06125682
78MP0003942_abnormal_urinary_system1.05751484
79MP0002557_abnormal_social/conspecific_i1.05738894
80MP0002116_abnormal_craniofacial_bone1.05309345
81MP0005386_behavior/neurological_phenoty1.04951538
82MP0004924_abnormal_behavior1.04951538
83MP0002067_abnormal_sensory_capabilities1.04924933
84MP0004130_abnormal_muscle_cell1.04474529
85MP0002909_abnormal_adrenal_gland1.04073956
86MP0004484_altered_response_of1.03831584
87MP0009053_abnormal_anal_canal1.03112025
88MP0002882_abnormal_neuron_morphology1.02913257
89MP0000631_abnormal_neuroendocrine_gland1.02119757
90MP0002752_abnormal_somatic_nervous1.01727741
91MP0005253_abnormal_eye_physiology1.01693596
92MP0002272_abnormal_nervous_system1.00705984
93MP0005257_abnormal_intraocular_pressure1.00449675
94MP0001529_abnormal_vocalization1.00375269
95MP0000049_abnormal_middle_ear0.99843278
96MP0001968_abnormal_touch/_nociception0.99227934
97MP0000537_abnormal_urethra_morphology0.98970690
98MP0002106_abnormal_muscle_physiology0.98668224
99* MP0002152_abnormal_brain_morphology0.98472135
100MP0002108_abnormal_muscle_morphology0.98467177
101MP0005369_muscle_phenotype0.97736052
102MP0009250_abnormal_appendicular_skeleto0.95613349
103MP0001177_atelectasis0.94610268
104MP0000750_abnormal_muscle_regeneration0.93654547
105MP0002269_muscular_atrophy0.93053410
106MP0000534_abnormal_ureter_morphology0.92206106
107MP0000428_abnormal_craniofacial_morphol0.91903881
108MP0002111_abnormal_tail_morphology0.91785854
109MP0000516_abnormal_urinary_system0.91762914
110MP0005367_renal/urinary_system_phenotyp0.91762914
111MP0009046_muscle_twitch0.90686309
112MP0003634_abnormal_glial_cell0.90653606
113MP0002932_abnormal_joint_morphology0.90583352
114MP0005551_abnormal_eye_electrophysiolog0.90540006
115MP0006072_abnormal_retinal_apoptosis0.89665698
116MP0000759_abnormal_skeletal_muscle0.89042602
117* MP0003861_abnormal_nervous_system0.88469770
118* MP0002084_abnormal_developmental_patter0.87824008
119MP0005503_abnormal_tendon_morphology0.87576185
120MP0004885_abnormal_endolymph0.87554727
121MP0002081_perinatal_lethality0.87402302
122MP0004811_abnormal_neuron_physiology0.86189075
123MP0010368_abnormal_lymphatic_system0.85739793
124MP0002697_abnormal_eye_size0.85272314
125MP0003937_abnormal_limbs/digits/tail_de0.84792064
126MP0002139_abnormal_hepatobiliary_system0.84665879
127MP0004142_abnormal_muscle_tone0.84213113
128MP0006054_spinal_hemorrhage0.84145280
129MP0000432_abnormal_head_morphology0.83495729
130MP0002233_abnormal_nose_morphology0.82205462
131MP0005195_abnormal_posterior_eye0.82115190
132MP0003755_abnormal_palate_morphology0.81290219
133MP0000569_abnormal_digit_pigmentation0.80764935
134MP0003115_abnormal_respiratory_system0.80384660
135MP0002735_abnormal_chemical_nociception0.80254050
136MP0003119_abnormal_digestive_system0.80173699
137MP0005197_abnormal_uvea_morphology0.80067942
138MP0001502_abnormal_circadian_rhythm0.80041492
139MP0002090_abnormal_vision0.79596304
140MP0003935_abnormal_craniofacial_develop0.79342270
141MP0002733_abnormal_thermal_nociception0.79337793
142MP0003315_abnormal_perineum_morphology0.79090556
143MP0003878_abnormal_ear_physiology0.78915685
144MP0005377_hearing/vestibular/ear_phenot0.78915685
145MP0002249_abnormal_larynx_morphology0.78713970
146MP0000647_abnormal_sebaceous_gland0.77960284
147MP0000462_abnormal_digestive_system0.77900915

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.63851245
2Vitreoretinal degeneration (HP:0000655)3.81224379
3Atrial fibrillation (HP:0005110)3.62494074
4Primary atrial arrhythmia (HP:0001692)3.46477021
5Supraventricular tachycardia (HP:0004755)3.23944942
6Supraventricular arrhythmia (HP:0005115)3.20367247
7Abnormality of the calf musculature (HP:0001430)3.15615805
8Syncope (HP:0001279)3.11792298
9Prolonged QT interval (HP:0001657)3.08166168
10Neonatal short-limb short stature (HP:0008921)2.94449286
11Calf muscle hypertrophy (HP:0008981)2.81936601
12Ventricular tachycardia (HP:0004756)2.81375198
13Septo-optic dysplasia (HP:0100842)2.67195632
14Hypoplastic pelvis (HP:0008839)2.57081133
15Muscle hypertrophy of the lower extremities (HP:0008968)2.56290595
16Abnormality of the ischium (HP:0003174)2.54947445
17Exercise-induced myalgia (HP:0003738)2.53778155
18Lipoatrophy (HP:0100578)2.48159403
19Cortical dysplasia (HP:0002539)2.47279348
20Anophthalmia (HP:0000528)2.46852636
21Ventricular arrhythmia (HP:0004308)2.44409465
22High anterior hairline (HP:0009890)2.41356209
23Short 4th metacarpal (HP:0010044)2.39462918
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39462918
25Muscle fiber splitting (HP:0003555)2.33391134
26Pheochromocytoma (HP:0002666)2.33306514
27Cutaneous finger syndactyly (HP:0010554)2.31377769
28Hepatoblastoma (HP:0002884)2.30258896
29Gait imbalance (HP:0002141)2.29709682
30Lymphangioma (HP:0100764)2.29258022
31Split foot (HP:0001839)2.27088471
32Subaortic stenosis (HP:0001682)2.26101859
33Abnormality of the left ventricular outflow tract (HP:0011103)2.26101859
34Vaginal atresia (HP:0000148)2.25973790
35Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25917142
36Bifid tongue (HP:0010297)2.23874053
37Genital tract atresia (HP:0001827)2.23663404
38Right ventricular cardiomyopathy (HP:0011663)2.23007666
39Preaxial foot polydactyly (HP:0001841)2.21978676
40Megalencephaly (HP:0001355)2.21145761
41Ketoacidosis (HP:0001993)2.21019148
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20661701
43Hyperventilation (HP:0002883)2.20560289
44True hermaphroditism (HP:0010459)2.19894625
45Hyporeflexia of lower limbs (HP:0002600)2.18401634
46Hypoplastic ischia (HP:0003175)2.18135699
47Congenital primary aphakia (HP:0007707)2.16031567
48Abnormal EKG (HP:0003115)2.15403200
49Bundle branch block (HP:0011710)2.14832584
50Postaxial hand polydactyly (HP:0001162)2.12207060
51Myelomeningocele (HP:0002475)2.11069044
52Renal hypoplasia (HP:0000089)2.10918459
53Atrioventricular block (HP:0001678)2.10391946
54Medial flaring of the eyebrow (HP:0010747)2.09657562
55Trigonocephaly (HP:0000243)2.09263212
56Termporal pattern (HP:0011008)2.07210558
57Insidious onset (HP:0003587)2.07210558
58Optic nerve hypoplasia (HP:0000609)2.05337105
59Cutaneous syndactyly (HP:0012725)2.04894027
60Nuclear cataract (HP:0100018)2.04029093
61Left ventricular hypertrophy (HP:0001712)2.03170529
62Wide anterior fontanel (HP:0000260)2.02182432
63Coronal craniosynostosis (HP:0004440)2.01649665
64Intestinal atresia (HP:0011100)1.99968119
65Buphthalmos (HP:0000557)1.99104176
66Ventricular fibrillation (HP:0001663)1.98265596
67Focal seizures (HP:0007359)1.98158018
68Hypoplastic left heart (HP:0004383)1.97789887
69Shallow orbits (HP:0000586)1.97768590
70Aplasia involving bones of the upper limbs (HP:0009823)1.97252359
71Aplasia of the phalanges of the hand (HP:0009802)1.97252359
72Aplasia involving bones of the extremities (HP:0009825)1.97252359
73Agitation (HP:0000713)1.97162490
74Abnormality of the pubic bones (HP:0003172)1.96249517
75Nephrogenic diabetes insipidus (HP:0009806)1.95114651
76Oligodactyly (HP:0012165)1.94882728
77Exercise-induced muscle cramps (HP:0003710)1.94821452
78Fibular hypoplasia (HP:0003038)1.94576892
79Drooling (HP:0002307)1.94424847
80Excessive salivation (HP:0003781)1.94424847
81Oligodactyly (hands) (HP:0001180)1.93968703
82Dilated cardiomyopathy (HP:0001644)1.93720359
83EMG: myopathic abnormalities (HP:0003458)1.92615124
84Neuroendocrine neoplasm (HP:0100634)1.91892287
85Heart block (HP:0012722)1.91780656
86Cerebral inclusion bodies (HP:0100314)1.91330921
87Pancreatic fibrosis (HP:0100732)1.90755978
88Hemivertebrae (HP:0002937)1.90150443
89Broad long bones (HP:0005622)1.87803537
90Neurofibrillary tangles (HP:0002185)1.86974194
91Hypoplastic heart (HP:0001961)1.84773559
92Palpitations (HP:0001962)1.84627004
93Difficulty running (HP:0009046)1.84343458
94Short tibia (HP:0005736)1.83150826
95Abnormality of the labia minora (HP:0012880)1.82739331
96Broad metatarsal (HP:0001783)1.81566944
97Broad thumb (HP:0011304)1.81448899
98Infantile muscular hypotonia (HP:0008947)1.81008432
99Focal motor seizures (HP:0011153)1.80513832
100Occipital encephalocele (HP:0002085)1.80292335
101Skin nodule (HP:0200036)1.80183991
102Broad foot (HP:0001769)1.79907649
103Bronchomalacia (HP:0002780)1.79596918
104Postaxial foot polydactyly (HP:0001830)1.79512622
105Abnormal atrioventricular conduction (HP:0005150)1.79383586
106Epileptic encephalopathy (HP:0200134)1.78778884
107Deep venous thrombosis (HP:0002625)1.78263417
108Hyperinsulinemic hypoglycemia (HP:0000825)1.78136348
109EEG with generalized epileptiform discharges (HP:0011198)1.77935267
110Progressive cerebellar ataxia (HP:0002073)1.77147360
111Micropenis (HP:0000054)1.77060951
112Myokymia (HP:0002411)1.76446547
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76436994
114Central scotoma (HP:0000603)1.75948663
115Rib fusion (HP:0000902)1.75786068
116Hypoglycemic coma (HP:0001325)1.75546577
117Pachygyria (HP:0001302)1.75514931
118Broad phalanx (HP:0006009)1.75237373
119Irregular epiphyses (HP:0010582)1.75177611
120Epileptiform EEG discharges (HP:0011182)1.74404395
121Abnormality of the aortic arch (HP:0012303)1.73604673
122Hypsarrhythmia (HP:0002521)1.73211246
123Preaxial hand polydactyly (HP:0001177)1.73192184
124Scapular winging (HP:0003691)1.72046547
125Absent epiphyses (HP:0010577)1.71851869
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71851869
127Abnormality of the antihelix (HP:0009738)1.71638540
128Nephronophthisis (HP:0000090)1.71486745
129Abnormality of the lower motor neuron (HP:0002366)1.70819610
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.70072536
131Partial duplication of thumb phalanx (HP:0009944)1.70051804
132Myoglobinuria (HP:0002913)1.69730378
133Hypoplasia of the ulna (HP:0003022)1.69397309
134Omphalocele (HP:0001539)1.68836746
135Vertebral clefting (HP:0008428)1.68613579
136Anencephaly (HP:0002323)1.68196013
137Arthropathy (HP:0003040)1.68138081
138Hamartoma of the eye (HP:0010568)1.68092259
139Athetosis (HP:0002305)1.67870948
140Back pain (HP:0003418)1.67792809
141Absent septum pellucidum (HP:0001331)1.67403016
142Ketosis (HP:0001946)1.67398641
143Broad finger (HP:0001500)1.66141785
144Broad phalanges of the hand (HP:0009768)1.65615321
145Rimmed vacuoles (HP:0003805)1.65313880
146Pancreatic cysts (HP:0001737)1.64546188
147Meningocele (HP:0002435)1.64365731
148Hemiparesis (HP:0001269)1.64283931
149Broad palm (HP:0001169)1.64103734
150Aplasia/Hypoplasia of the fibula (HP:0006492)1.63471069
151Renal dysplasia (HP:0000110)1.63295182
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.63180728
153Limited hip movement (HP:0008800)1.63057398
154Hyperglycinemia (HP:0002154)1.61915950
155Overgrowth (HP:0001548)1.61554798
156Lissencephaly (HP:0001339)1.61479263
157Poor coordination (HP:0002370)1.60699805
158Abnormality of the corticospinal tract (HP:0002492)1.60414302
159Colon cancer (HP:0003003)1.60368073
160Abnormality of the intervertebral disk (HP:0005108)1.60316830
161Hyperglycemia (HP:0003074)1.59251295
162Soft skin (HP:0000977)1.58741096
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.58398353
164Lower limb amyotrophy (HP:0007210)1.58189185
165Asymmetric septal hypertrophy (HP:0001670)1.58083004
166Abnormality of midbrain morphology (HP:0002418)1.58038861
167Molar tooth sign on MRI (HP:0002419)1.58038861
168Dysdiadochokinesis (HP:0002075)1.57968052
169Midline defect of the nose (HP:0004122)1.57513422
170Morphological abnormality of the middle ear (HP:0008609)1.57274681
171Short foot (HP:0001773)1.56961643
172Bicornuate uterus (HP:0000813)1.56837345
173Abnormality of the 4th metacarpal (HP:0010012)1.56372138
174Aplasia/Hypoplasia of the ulna (HP:0006495)1.56309172
175Synostosis of carpal bones (HP:0005048)1.56149796
176Partial duplication of the phalanx of hand (HP:0009999)1.55957048
177Lower limb muscle weakness (HP:0007340)1.53773981
178Zonular cataract (HP:0010920)1.52858575
179Abnormality of dentin (HP:0010299)1.52847600
180Turricephaly (HP:0000262)1.52430571
181Atonic seizures (HP:0010819)1.51446214
182Aplasia/Hypoplasia of the brainstem (HP:0007362)1.51277265
183Hypoplasia of the brainstem (HP:0002365)1.51277265
184Broad-based gait (HP:0002136)1.51250838
185Maternal diabetes (HP:0009800)1.48765722
186Fetal akinesia sequence (HP:0001989)1.48719595
187Increased variability in muscle fiber diameter (HP:0003557)1.48546965
188Myotonia (HP:0002486)1.48434254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.84686389
2PHKG22.76039134
3PHKG12.76039134
4EPHA42.40827275
5MAP3K42.23718350
6PAK32.22931867
7NTRK32.11625071
8PAK62.11316361
9TRIM281.94248617
10NTRK21.93662389
11EPHB21.92045541
12CASK1.90678963
13INSRR1.90101847
14LMTK21.85615299
15TTN1.77033132
16MKNK11.73058391
17MAPK131.70690399
18KSR11.69934351
19MAP4K21.64896384
20LATS21.58981208
21UHMK11.58318471
22SRPK11.56547112
23MINK11.50469917
24PRKD31.49750375
25MKNK21.47481004
26DMPK1.45857296
27EPHA31.36535673
28PDGFRA1.29325387
29MAP2K71.28189676
30TRIB31.26160484
31DYRK31.24707969
32PINK11.24565650
33SIK11.23739013
34BCR1.23726192
35ROCK11.22362648
36FGFR21.20087455
37DYRK21.19469157
38PIK3CA1.17833057
39OBSCN1.16148800
40ERBB31.15800060
41LATS11.15672767
42MAP3K91.15574448
43MAP2K41.14742467
44CSNK1G11.14581443
45CSNK1G31.14275327
46ICK1.13717645
47PKN11.11678136
48BMPR1B1.10002576
49CAMK2A1.09473662
50CDC42BPA1.09064995
51BRD41.08920836
52NEK91.08860483
53PKN21.08665171
54NTRK11.08297283
55RPS6KA41.07208188
56TNIK1.05515977
57CAMK1G1.05014554
58PNCK1.04036676
59CAMK2D1.03691232
60TYRO31.03319757
61PDK31.02824356
62PDK41.02824356
63LIMK11.02167332
64PLK21.01421087
65MYLK0.97895289
66DDR20.97110771
67WNK40.96531322
68ROCK20.95084529
69MAP3K100.91707440
70MUSK0.90251823
71CDK50.88861407
72CDK190.86119681
73SIK20.84910985
74BCKDK0.83346962
75PRKCE0.83014068
76FER0.82995461
77WEE10.80761463
78PRPF4B0.79082356
79STK390.78410452
80DYRK1B0.76194822
81ERBB20.75200670
82PLK30.74989600
83ERBB40.73999035
84CDK140.72846313
85PRKCG0.72050070
86SGK4940.71329043
87SGK2230.71329043
88DYRK1A0.70833688
89RET0.69922215
90CSNK1G20.69636036
91CDK180.69523165
92NEK10.68672760
93PRKD10.68016309
94CDK150.67715357
95FGFR10.66030965
96STK240.64173818
97CAMK2B0.63584477
98PTK2B0.62937859
99DAPK20.62530014
100FLT30.62280394
101ILK0.61157906
102PLK40.57827593
103ADRBK10.56918313
104PRKAA10.56876077
105PRKCZ0.56509072
106CDC70.56409358
107PAK20.55790554
108WNK10.55503248
109NEK20.55279328
110CDK11A0.54951876
111STK380.54748316
112CAMK40.54579630
113NUAK10.54325336
114STK38L0.52882873
115GRK70.52785015
116MAPK150.51976549
117PTK20.50662140
118MARK20.50576701
119MAPK120.50507895
120KSR20.50298158
121STK110.50261711
122CSNK1A1L0.49657870
123CAMKK10.49561712
124PRKCH0.49227474
125AKT30.48629297
126WNK30.48020492
127SGK10.45781862
128TIE10.42240350
129BRSK20.40470727
130PLK10.37917452
131MOS0.37199452
132PRKACB0.36920098
133TGFBR10.36906034
134CSNK1D0.35802644
135SGK20.35507548
136VRK10.35122228
137PRKDC0.33425168
138CDK30.31607783
139YES10.31277059

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27461870
2Dilated cardiomyopathy_Homo sapiens_hsa054142.25351629
3Cardiac muscle contraction_Homo sapiens_hsa042602.20068823
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05952793
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03268799
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97604827
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96779972
8Butanoate metabolism_Homo sapiens_hsa006501.90726624
9Protein export_Homo sapiens_hsa030601.88706674
10Nicotine addiction_Homo sapiens_hsa050331.88614963
11Nitrogen metabolism_Homo sapiens_hsa009101.85476920
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79726746
13Fatty acid metabolism_Homo sapiens_hsa012121.78929809
14Fatty acid degradation_Homo sapiens_hsa000711.77198528
15* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71905665
16Axon guidance_Homo sapiens_hsa043601.65465665
17GABAergic synapse_Homo sapiens_hsa047271.63430829
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62922259
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62621942
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59938069
21Propanoate metabolism_Homo sapiens_hsa006401.53723268
22Circadian entrainment_Homo sapiens_hsa047131.52652598
23Glutamatergic synapse_Homo sapiens_hsa047241.45916835
24Insulin secretion_Homo sapiens_hsa049111.44027544
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43497018
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42613389
27TGF-beta signaling pathway_Homo sapiens_hsa043501.39602919
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31583145
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.28082489
30Morphine addiction_Homo sapiens_hsa050321.23255632
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22383720
32Dopaminergic synapse_Homo sapiens_hsa047281.21555012
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19844232
34Amphetamine addiction_Homo sapiens_hsa050311.14466008
35Arginine biosynthesis_Homo sapiens_hsa002201.12198457
36Cocaine addiction_Homo sapiens_hsa050301.11859568
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06459874
38Tryptophan metabolism_Homo sapiens_hsa003801.05880460
39Taste transduction_Homo sapiens_hsa047421.05741645
40Long-term potentiation_Homo sapiens_hsa047201.05529079
41Cholinergic synapse_Homo sapiens_hsa047251.05474428
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05386335
43Fatty acid elongation_Homo sapiens_hsa000621.04916181
44Protein digestion and absorption_Homo sapiens_hsa049741.03480020
45Renin secretion_Homo sapiens_hsa049241.02252070
46Gap junction_Homo sapiens_hsa045401.00223860
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99401155
48Basal cell carcinoma_Homo sapiens_hsa052170.98512195
49PPAR signaling pathway_Homo sapiens_hsa033200.98410737
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98121845
51Olfactory transduction_Homo sapiens_hsa047400.98090329
52Oxytocin signaling pathway_Homo sapiens_hsa049210.97739816
53Serotonergic synapse_Homo sapiens_hsa047260.97405133
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97314588
55Melanogenesis_Homo sapiens_hsa049160.97213123
56Glucagon signaling pathway_Homo sapiens_hsa049220.96226411
57Hedgehog signaling pathway_Homo sapiens_hsa043400.96069847
58Type II diabetes mellitus_Homo sapiens_hsa049300.96028372
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93491220
60Bile secretion_Homo sapiens_hsa049760.92012085
61Pyruvate metabolism_Homo sapiens_hsa006200.90988494
62Parkinsons disease_Homo sapiens_hsa050120.89791464
63Alzheimers disease_Homo sapiens_hsa050100.89007838
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86863964
65Oxidative phosphorylation_Homo sapiens_hsa001900.86755212
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85123087
67Phototransduction_Homo sapiens_hsa047440.84016261
68Synaptic vesicle cycle_Homo sapiens_hsa047210.83137786
69Gastric acid secretion_Homo sapiens_hsa049710.82799506
70Lysine degradation_Homo sapiens_hsa003100.81172109
71Calcium signaling pathway_Homo sapiens_hsa040200.79944924
72Fatty acid biosynthesis_Homo sapiens_hsa000610.79651568
73Fanconi anemia pathway_Homo sapiens_hsa034600.79150194
74cAMP signaling pathway_Homo sapiens_hsa040240.77488068
75Biosynthesis of amino acids_Homo sapiens_hsa012300.77328821
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76345683
77Wnt signaling pathway_Homo sapiens_hsa043100.76309877
78Basal transcription factors_Homo sapiens_hsa030220.75083316
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74763677
80GnRH signaling pathway_Homo sapiens_hsa049120.73906840
81Hippo signaling pathway_Homo sapiens_hsa043900.73783029
82Salivary secretion_Homo sapiens_hsa049700.73623617
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72884759
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.72154756
85Estrogen signaling pathway_Homo sapiens_hsa049150.71293213
86Carbon metabolism_Homo sapiens_hsa012000.70859926
87Long-term depression_Homo sapiens_hsa047300.70798076
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70794918
89Dorso-ventral axis formation_Homo sapiens_hsa043200.69246624
90Prion diseases_Homo sapiens_hsa050200.69017517
91Colorectal cancer_Homo sapiens_hsa052100.67685684
92Circadian rhythm_Homo sapiens_hsa047100.66296677
93Insulin signaling pathway_Homo sapiens_hsa049100.66139715
94Viral myocarditis_Homo sapiens_hsa054160.65190723
95Focal adhesion_Homo sapiens_hsa045100.64716823
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64577140
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.64360765
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64137662
99Tight junction_Homo sapiens_hsa045300.62974665
100Renal cell carcinoma_Homo sapiens_hsa052110.61911321
101Glioma_Homo sapiens_hsa052140.61240774
102Sulfur metabolism_Homo sapiens_hsa009200.61076216
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60869679
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59721728
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59311427
106mRNA surveillance pathway_Homo sapiens_hsa030150.59153836
107Non-homologous end-joining_Homo sapiens_hsa034500.59086027
108AMPK signaling pathway_Homo sapiens_hsa041520.58818998
109Pathways in cancer_Homo sapiens_hsa052000.58020891
110Huntingtons disease_Homo sapiens_hsa050160.57636160
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56845686
112ErbB signaling pathway_Homo sapiens_hsa040120.56574503
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56549875
114Insulin resistance_Homo sapiens_hsa049310.56306162
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56176451
116Spliceosome_Homo sapiens_hsa030400.55863631
117Oocyte meiosis_Homo sapiens_hsa041140.54754958
118Arginine and proline metabolism_Homo sapiens_hsa003300.54565854
119RNA degradation_Homo sapiens_hsa030180.53472050
120beta-Alanine metabolism_Homo sapiens_hsa004100.53308469
121Starch and sucrose metabolism_Homo sapiens_hsa005000.52337885
122MicroRNAs in cancer_Homo sapiens_hsa052060.52291943
123ECM-receptor interaction_Homo sapiens_hsa045120.52190146
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.51571119
125Rap1 signaling pathway_Homo sapiens_hsa040150.51486867
126Alcoholism_Homo sapiens_hsa050340.51468981
127Notch signaling pathway_Homo sapiens_hsa043300.51372372
128Adherens junction_Homo sapiens_hsa045200.50463007
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49570756
130Melanoma_Homo sapiens_hsa052180.49153540
131Complement and coagulation cascades_Homo sapiens_hsa046100.48704220
132Thyroid hormone synthesis_Homo sapiens_hsa049180.47792209
133Peroxisome_Homo sapiens_hsa041460.47141957
134Steroid biosynthesis_Homo sapiens_hsa001000.46989693
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46520071
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.45831857
137Cell cycle_Homo sapiens_hsa041100.43363531
138Proteoglycans in cancer_Homo sapiens_hsa052050.39657732
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38254009
140RNA transport_Homo sapiens_hsa030130.37649303
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37471024

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »