CDH22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.08527592
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20314982
3synaptic vesicle maturation (GO:0016188)6.17995380
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.13361133
5locomotory exploration behavior (GO:0035641)5.78546108
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32563478
7vocalization behavior (GO:0071625)5.24852358
8regulation of synaptic vesicle exocytosis (GO:2000300)5.15426028
9synaptic vesicle exocytosis (GO:0016079)5.13532525
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10827491
11glutamate secretion (GO:0014047)4.89110084
12layer formation in cerebral cortex (GO:0021819)4.75331347
13neurotransmitter secretion (GO:0007269)4.65948466
14neuronal action potential propagation (GO:0019227)4.63478677
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.63266598
16regulation of glutamate receptor signaling pathway (GO:1900449)4.59285296
17gamma-aminobutyric acid transport (GO:0015812)4.55785250
18dendritic spine morphogenesis (GO:0060997)4.49963836
19regulation of synaptic vesicle transport (GO:1902803)4.49028993
20protein localization to synapse (GO:0035418)4.44575212
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.43891458
22L-amino acid import (GO:0043092)4.43834688
23neuron cell-cell adhesion (GO:0007158)4.42630641
24regulation of synapse structural plasticity (GO:0051823)4.34143220
25exploration behavior (GO:0035640)4.31798038
26synaptic transmission, glutamatergic (GO:0035249)4.17335142
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17183457
28regulation of neuronal synaptic plasticity (GO:0048168)4.16090085
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12114162
30sodium ion export (GO:0071436)4.11136878
31cellular potassium ion homeostasis (GO:0030007)4.10422731
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.05284924
33regulation of synapse maturation (GO:0090128)4.02717527
34amino acid import (GO:0043090)3.98640066
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95237699
36auditory behavior (GO:0031223)3.94711251
37positive regulation of neurotransmitter secretion (GO:0001956)3.92375492
38glutamate receptor signaling pathway (GO:0007215)3.89924207
39glycine transport (GO:0015816)3.88751891
40neuromuscular process controlling posture (GO:0050884)3.87071974
41neuron-neuron synaptic transmission (GO:0007270)3.85761289
42cerebellar Purkinje cell differentiation (GO:0021702)3.84355886
43activation of protein kinase A activity (GO:0034199)3.83154234
44neurotransmitter transport (GO:0006836)3.67208252
45negative regulation of dendrite morphogenesis (GO:0050774)3.63990902
46regulation of voltage-gated calcium channel activity (GO:1901385)3.62184260
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.62078998
48long-term memory (GO:0007616)3.61322537
49neuromuscular process controlling balance (GO:0050885)3.61127685
50proline transport (GO:0015824)3.58059392
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.57741360
52response to auditory stimulus (GO:0010996)3.56721124
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56385829
54positive regulation of membrane potential (GO:0045838)3.56343053
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56152286
56neurotransmitter-gated ion channel clustering (GO:0072578)3.54305373
57cell communication by electrical coupling (GO:0010644)3.53900244
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53358415
59chemosensory behavior (GO:0007635)3.52402437
60axon ensheathment in central nervous system (GO:0032291)3.51971423
61central nervous system myelination (GO:0022010)3.51971423
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50908658
63regulation of postsynaptic membrane potential (GO:0060078)3.50512020
64synaptic vesicle endocytosis (GO:0048488)3.50372527
65cellular sodium ion homeostasis (GO:0006883)3.48968843
66regulation of neurotransmitter levels (GO:0001505)3.48406301
67membrane hyperpolarization (GO:0060081)3.41394715
68regulation of neurotransmitter secretion (GO:0046928)3.41215935
69dendrite morphogenesis (GO:0048813)3.39255631
70regulation of dendritic spine development (GO:0060998)3.37829506
71neuron recognition (GO:0008038)3.35564594
72cerebellar Purkinje cell layer development (GO:0021680)3.34020995
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32241221
74axonal fasciculation (GO:0007413)3.30654179
75postsynaptic membrane organization (GO:0001941)3.29936028
76neuromuscular synaptic transmission (GO:0007274)3.29738140
77transmission of nerve impulse (GO:0019226)3.28792001
78prepulse inhibition (GO:0060134)3.28766956
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27535518
80signal release (GO:0023061)3.24044860
81positive regulation of synapse maturation (GO:0090129)3.23312756
82regulation of synaptic transmission (GO:0050804)3.21085258
83regulation of ARF protein signal transduction (GO:0032012)3.20572925
84regulation of synaptic plasticity (GO:0048167)3.20031437
85innervation (GO:0060384)3.18847577
86synaptic transmission (GO:0007268)3.18300298
87regulation of dendritic spine morphogenesis (GO:0061001)3.17217992
88cell migration in hindbrain (GO:0021535)3.17073946
89regulation of neurotransmitter transport (GO:0051588)3.16987941
90regulation of vesicle fusion (GO:0031338)3.16974068
91cerebellar granule cell differentiation (GO:0021707)3.16021799
92detection of calcium ion (GO:0005513)3.15105403
93neurotransmitter uptake (GO:0001504)3.14194229
94acidic amino acid transport (GO:0015800)3.12871591
95establishment of synaptic vesicle localization (GO:0097480)3.11518297
96synaptic vesicle transport (GO:0048489)3.11518297
97membrane depolarization during action potential (GO:0086010)3.10890176
98mating behavior (GO:0007617)3.10828280
99membrane depolarization (GO:0051899)3.10610458
100vesicle docking involved in exocytosis (GO:0006904)3.09859647
101regulation of exocytosis (GO:0017157)3.09783361
102long-term synaptic potentiation (GO:0060291)3.09088178
103regulation of synaptic transmission, glutamatergic (GO:0051966)3.08351069
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07669927
105dendritic spine organization (GO:0097061)3.07301544
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07115620
107gamma-aminobutyric acid signaling pathway (GO:0007214)3.06170562
108cytoskeletal anchoring at plasma membrane (GO:0007016)3.05538295
109regulation of calcium ion-dependent exocytosis (GO:0017158)3.05009912
110regulation of respiratory system process (GO:0044065)3.04858495
111mechanosensory behavior (GO:0007638)3.03919464
112neuronal ion channel clustering (GO:0045161)3.00988463
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98669539
114intraspecies interaction between organisms (GO:0051703)2.98356125
115social behavior (GO:0035176)2.98356125
116positive regulation of dendritic spine development (GO:0060999)2.97441777
117negative regulation of microtubule polymerization (GO:0031115)2.97185495
118synapse assembly (GO:0007416)2.96963179
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96802095
120neuromuscular process (GO:0050905)2.96617165
121regulation of respiratory gaseous exchange (GO:0043576)2.94637127
122potassium ion homeostasis (GO:0055075)2.94527187
123cell differentiation in hindbrain (GO:0021533)2.94299669
124potassium ion import (GO:0010107)2.90874606
125learning (GO:0007612)2.88111821
126positive regulation of neurotransmitter transport (GO:0051590)2.84807692
127synapse organization (GO:0050808)2.84396914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83582924
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22147231
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21338689
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12955893
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95961489
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95961489
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.90266860
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.90128578
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.81869572
10GBX2_23144817_ChIP-Seq_PC3_Human2.74570684
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73312707
12DROSHA_22980978_ChIP-Seq_HELA_Human2.72362227
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64741116
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63795423
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63532435
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63492318
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.61762119
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.60698170
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58990583
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57324581
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56896852
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52453734
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.46452048
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46310088
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.46287888
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40607273
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38385926
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.01358750
29AR_21572438_ChIP-Seq_LNCaP_Human1.75353454
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71555039
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65327402
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63859043
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62778656
34* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53808953
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.53357727
36* KDM2B_26808549_Chip-Seq_K562_Human1.52971622
37ZNF274_21170338_ChIP-Seq_K562_Hela1.51754984
38* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43210571
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39360864
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38591556
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36712042
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36443201
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35006428
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29038084
45* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24801430
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24328913
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22094033
48SMAD4_21799915_ChIP-Seq_A2780_Human1.21236773
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20853528
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19442171
51* AR_19668381_ChIP-Seq_PC3_Human1.18440683
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18144236
53* CBX2_27304074_Chip-Seq_ESCs_Mouse1.18067777
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17960432
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17816352
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16388292
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15265135
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14515486
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10509384
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08407539
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05831631
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04626636
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04507445
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04154632
65* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03835116
66CTCF_27219007_Chip-Seq_Bcells_Human1.02830743
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01323629
68RNF2_27304074_Chip-Seq_NSC_Mouse1.00948168
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00564004
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99848837
71KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99413668
72SMAD3_21741376_ChIP-Seq_ESCs_Human0.99126056
73YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98441178
74* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96710839
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96270815
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94069271
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94069271
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93395221
79SMAD3_21741376_ChIP-Seq_EPCs_Human0.93284749
80OCT4_19829295_ChIP-Seq_ESCs_Human0.93222554
81TAF15_26573619_Chip-Seq_HEK293_Human0.91387284
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91069486
83AR_25329375_ChIP-Seq_VCAP_Human0.91020710
84IGF1R_20145208_ChIP-Seq_DFB_Human0.90393993
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90373972
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89962496
87* STAT3_23295773_ChIP-Seq_U87_Human0.89596399
88LXR_22292898_ChIP-Seq_THP-1_Human0.88738419
89* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88041110
90P300_19829295_ChIP-Seq_ESCs_Human0.87831827
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86909356
92* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86738053
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85867938
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.85643941
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85600493
96DPY_21335234_ChIP-Seq_ESCs_Mouse0.85478959
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85290177
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.84367855
99AHR_22903824_ChIP-Seq_MCF-7_Human0.83172727
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.82993156
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82662250
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82146853
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80782068
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80461221
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80050485
106SMAD4_21741376_ChIP-Seq_ESCs_Human0.79552954
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79108708
108KLF4_19829295_ChIP-Seq_ESCs_Human0.78096983
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77351322
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76567384
111* SMC4_20622854_ChIP-Seq_HELA_Human0.75943315
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75826268
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75813492
114RUNX2_22187159_ChIP-Seq_PCA_Human0.75495853
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75349605
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75097275
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74812722
118* TCF4_23295773_ChIP-Seq_U87_Human0.74776251
119KDM2B_26808549_Chip-Seq_DND41_Human0.74510811
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73247616
121* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71814914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.18508793
2MP0003635_abnormal_synaptic_transmissio4.11683330
3MP0003880_abnormal_central_pattern4.07487444
4MP0004270_analgesia3.34115442
5MP0009046_muscle_twitch3.29314666
6MP0002063_abnormal_learning/memory/cond3.26130835
7MP0009745_abnormal_behavioral_response3.14598008
8MP0005423_abnormal_somatic_nervous3.06345645
9MP0002064_seizures3.04058967
10MP0002572_abnormal_emotion/affect_behav2.65965744
11MP0002272_abnormal_nervous_system2.54798858
12MP0001486_abnormal_startle_reflex2.49602412
13MP0001968_abnormal_touch/_nociception2.49161950
14MP0002734_abnormal_mechanical_nocicepti2.38232571
15MP0008569_lethality_at_weaning2.25630241
16MP0002909_abnormal_adrenal_gland2.15149099
17MP0002822_catalepsy2.10684346
18MP0001440_abnormal_grooming_behavior2.09968038
19MP0002184_abnormal_innervation2.09526105
20MP0002733_abnormal_thermal_nociception2.08494813
21MP0000778_abnormal_nervous_system2.06662708
22MP0004858_abnormal_nervous_system2.06456134
23MP0001501_abnormal_sleep_pattern2.02741934
24MP0005645_abnormal_hypothalamus_physiol1.95952277
25MP0003122_maternal_imprinting1.92612935
26MP0002067_abnormal_sensory_capabilities1.92354922
27MP0002557_abnormal_social/conspecific_i1.90223428
28MP0001970_abnormal_pain_threshold1.89934662
29MP0004811_abnormal_neuron_physiology1.89210967
30MP0009780_abnormal_chondrocyte_physiolo1.85658690
31MP0003329_amyloid_beta_deposits1.81137828
32MP0006276_abnormal_autonomic_nervous1.80019429
33MP0000955_abnormal_spinal_cord1.79104050
34MP0002736_abnormal_nociception_after1.74370017
35MP0004142_abnormal_muscle_tone1.71690816
36MP0004924_abnormal_behavior1.69767576
37MP0005386_behavior/neurological_phenoty1.69767576
38MP0002735_abnormal_chemical_nociception1.69499171
39MP0003283_abnormal_digestive_organ1.62984116
40MP0001502_abnormal_circadian_rhythm1.59549582
41MP0004145_abnormal_muscle_electrophysio1.53217775
42MP0004885_abnormal_endolymph1.52459373
43MP0002882_abnormal_neuron_morphology1.46926362
44MP0002066_abnormal_motor_capabilities/c1.45723322
45MP0003879_abnormal_hair_cell1.45016338
46MP0005646_abnormal_pituitary_gland1.44633272
47MP0001984_abnormal_olfaction1.40789291
48MP0008961_abnormal_basal_metabolism1.36490679
49MP0001529_abnormal_vocalization1.33830988
50MP0004043_abnormal_pH_regulation1.33781869
51MP0000569_abnormal_digit_pigmentation1.31190635
52MP0003787_abnormal_imprinting1.28575404
53MP0008877_abnormal_DNA_methylation1.24454087
54MP0000013_abnormal_adipose_tissue1.22031141
55MP0002152_abnormal_brain_morphology1.21716169
56MP0003633_abnormal_nervous_system1.20759240
57MP0002638_abnormal_pupillary_reflex1.12991166
58MP0001986_abnormal_taste_sensitivity1.12571202
59MP0005394_taste/olfaction_phenotype1.03447759
60MP0005499_abnormal_olfactory_system1.03447759
61MP0003631_nervous_system_phenotype1.02873731
62MP0002069_abnormal_eating/drinking_beha1.01879571
63MP0001348_abnormal_lacrimal_gland0.98250109
64MP0000751_myopathy0.97896953
65MP0004742_abnormal_vestibular_system0.97639602
66MP0002653_abnormal_ependyma_morphology0.96420296
67MP0003634_abnormal_glial_cell0.95510690
68MP0001485_abnormal_pinna_reflex0.91917677
69MP0010386_abnormal_urinary_bladder0.91254953
70MP0008872_abnormal_physiological_respon0.91085462
71MP0000631_abnormal_neuroendocrine_gland0.90773693
72MP0003632_abnormal_nervous_system0.85792844
73MP0002229_neurodegeneration0.85665921
74MP0001905_abnormal_dopamine_level0.84527525
75MP0005167_abnormal_blood-brain_barrier0.80642496
76MP0001177_atelectasis0.80011948
77MP0005187_abnormal_penis_morphology0.79710439
78MP0005623_abnormal_meninges_morphology0.77682771
79MP0002752_abnormal_somatic_nervous0.76489104
80MP0004085_abnormal_heartbeat0.76355704
81MP0001346_abnormal_lacrimal_gland0.76008369
82MP0003172_abnormal_lysosome_physiology0.74362734
83MP0004233_abnormal_muscle_weight0.73582071
84MP0006072_abnormal_retinal_apoptosis0.73529024
85MP0003690_abnormal_glial_cell0.73319078
86MP0004510_myositis0.72764799
87MP0003861_abnormal_nervous_system0.72188054
88MP0000604_amyloidosis0.71254992
89MP0003075_altered_response_to0.69574432
90MP0005551_abnormal_eye_electrophysiolog0.68618084
91MP0004147_increased_porphyrin_level0.68610518
92MP0002751_abnormal_autonomic_nervous0.67951041
93MP0005535_abnormal_body_temperature0.67803845
94MP0008874_decreased_physiological_sensi0.67563499
95MP0003121_genomic_imprinting0.67524241
96MP0000920_abnormal_myelination0.67266556
97MP0001943_abnormal_respiration0.66713618
98MP0001963_abnormal_hearing_physiology0.66316820
99MP0001188_hyperpigmentation0.64597453
100MP0010769_abnormal_survival0.64555207
101MP0000566_synostosis0.64419028
102MP0003137_abnormal_impulse_conducting0.64331823
103MP0001299_abnormal_eye_distance/0.63391191
104MP0002082_postnatal_lethality0.63211750
105MP0010770_preweaning_lethality0.63211750
106MP0000534_abnormal_ureter_morphology0.62010120
107MP0010768_mortality/aging0.60324473
108MP0002090_abnormal_vision0.56925177
109MP0003123_paternal_imprinting0.55891242
110MP0002089_abnormal_postnatal_growth/wei0.55314894
111MP0002837_dystrophic_cardiac_calcinosis0.55121892
112MP0001944_abnormal_pancreas_morphology0.55027731
113MP0003045_fibrosis0.53530681
114MP0000639_abnormal_adrenal_gland0.52679005
115MP0004130_abnormal_muscle_cell0.52616736
116MP0000026_abnormal_inner_ear0.50031350
117MP0003956_abnormal_body_size0.49637781
118MP0001765_abnormal_ion_homeostasis0.45114031

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.10365879
2Focal motor seizures (HP:0011153)6.08499844
3Visual hallucinations (HP:0002367)5.27418047
4Focal seizures (HP:0007359)5.10772359
5Progressive cerebellar ataxia (HP:0002073)4.21652974
6Action tremor (HP:0002345)4.09453233
7Failure to thrive in infancy (HP:0001531)3.92502791
8Atonic seizures (HP:0010819)3.88994814
9Epileptic encephalopathy (HP:0200134)3.88357989
10Supranuclear gaze palsy (HP:0000605)3.77384176
11Febrile seizures (HP:0002373)3.66371561
12Cerebral hypomyelination (HP:0006808)3.59511480
13Absence seizures (HP:0002121)3.47578269
14Depression (HP:0000716)3.47273801
15Agitation (HP:0000713)3.43363156
16Generalized tonic-clonic seizures (HP:0002069)3.35339827
17Obstructive sleep apnea (HP:0002870)3.30405146
18Dysdiadochokinesis (HP:0002075)3.29547614
19Ankle clonus (HP:0011448)3.28381343
20Poor eye contact (HP:0000817)3.21125417
21Hemiparesis (HP:0001269)3.19415416
22Abnormal eating behavior (HP:0100738)3.12322146
23Truncal ataxia (HP:0002078)3.08693865
24Dialeptic seizures (HP:0011146)3.05819107
25Broad-based gait (HP:0002136)3.04152206
26Anxiety (HP:0000739)2.97574920
27Hemiplegia (HP:0002301)2.97194570
28Mutism (HP:0002300)2.96219988
29Impaired vibration sensation in the lower limbs (HP:0002166)2.96008041
30Gaze-evoked nystagmus (HP:0000640)2.94474543
31Papilledema (HP:0001085)2.93019232
32Impaired smooth pursuit (HP:0007772)2.91662245
33Akinesia (HP:0002304)2.88417821
34Limb dystonia (HP:0002451)2.87749126
35Abnormal social behavior (HP:0012433)2.83831204
36Impaired social interactions (HP:0000735)2.83831204
37Dysmetria (HP:0001310)2.83672126
38Pheochromocytoma (HP:0002666)2.82830424
39Amblyopia (HP:0000646)2.80145657
40Hyperacusis (HP:0010780)2.79602174
41Intention tremor (HP:0002080)2.77499339
42Insomnia (HP:0100785)2.76377237
43Hypoglycemic seizures (HP:0002173)2.75426458
44Ventricular fibrillation (HP:0001663)2.71265551
45Delusions (HP:0000746)2.69432391
46Urinary bladder sphincter dysfunction (HP:0002839)2.68012331
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63567239
48Hyperinsulinemic hypoglycemia (HP:0000825)2.63084354
49Neoplasm of the heart (HP:0100544)2.61890873
50Abnormality of the lower motor neuron (HP:0002366)2.61738015
51Polyphagia (HP:0002591)2.59639050
52Genetic anticipation (HP:0003743)2.57165739
53Postural instability (HP:0002172)2.55532303
54Megalencephaly (HP:0001355)2.53956537
55Sleep apnea (HP:0010535)2.52588196
56Abnormality of ocular smooth pursuit (HP:0000617)2.51953790
57Scanning speech (HP:0002168)2.51668236
58Neurofibrillary tangles (HP:0002185)2.46460780
59Excessive salivation (HP:0003781)2.45808113
60Drooling (HP:0002307)2.45808113
61Spastic gait (HP:0002064)2.44451581
62EEG with generalized epileptiform discharges (HP:0011198)2.42472767
63Epileptiform EEG discharges (HP:0011182)2.40515150
64Pointed chin (HP:0000307)2.40438924
65Focal dystonia (HP:0004373)2.38507834
66Urinary urgency (HP:0000012)2.38163972
67Hypsarrhythmia (HP:0002521)2.35753254
68Dysmetric saccades (HP:0000641)2.35025862
69Stereotypic behavior (HP:0000733)2.33058247
70Rigidity (HP:0002063)2.29253267
71Neuroendocrine neoplasm (HP:0100634)2.27594543
72Torticollis (HP:0000473)2.26138594
73Cerebral inclusion bodies (HP:0100314)2.26072447
74Hypercortisolism (HP:0001578)2.25133083
75Diplopia (HP:0000651)2.25012488
76Abnormality of binocular vision (HP:0011514)2.25012488
77CNS hypomyelination (HP:0003429)2.24302425
78Increased circulating renin level (HP:0000848)2.23123763
79Status epilepticus (HP:0002133)2.22398763
80Annular pancreas (HP:0001734)2.20801393
81Tetraplegia (HP:0002445)2.18534655
82Peripheral hypomyelination (HP:0007182)2.18212850
83Lower limb asymmetry (HP:0100559)2.13741857
84Hypoventilation (HP:0002791)2.13678522
85Bradykinesia (HP:0002067)2.12588413
86Choreoathetosis (HP:0001266)2.12509537
87Abnormality of the aortic arch (HP:0012303)2.08451684
88Progressive inability to walk (HP:0002505)2.08280659
89Large eyes (HP:0001090)2.06143100
90Diminished motivation (HP:0000745)2.05920807
91Bundle branch block (HP:0011710)2.03869438
92Spastic tetraparesis (HP:0001285)2.02676818
93Incomplete penetrance (HP:0003829)2.00339986
94Neuronal loss in central nervous system (HP:0002529)1.99379937
95Abnormality of the corticospinal tract (HP:0002492)1.99133683
96Morphological abnormality of the pyramidal tract (HP:0002062)1.98388811
97Fetal akinesia sequence (HP:0001989)1.98258204
98Unsteady gait (HP:0002317)1.97223890
99Lower limb muscle weakness (HP:0007340)1.96412225
100Hypoglycemic coma (HP:0001325)1.96223605
101Absent speech (HP:0001344)1.94129850
102Clonus (HP:0002169)1.93617413
103Insulin-resistant diabetes mellitus (HP:0000831)1.93353113
104Restlessness (HP:0000711)1.91934504
105Specific learning disability (HP:0001328)1.91674552
106Gait ataxia (HP:0002066)1.91656144
107Craniofacial dystonia (HP:0012179)1.90715082
108Generalized hypotonia (HP:0001290)1.90507482
109Spinal canal stenosis (HP:0003416)1.89945639
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.88788200
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88788200
112Psychosis (HP:0000709)1.88220782
113Apathy (HP:0000741)1.88147629
114Abnormal EKG (HP:0003115)1.86964640
115Amyotrophic lateral sclerosis (HP:0007354)1.85972625
116Rapidly progressive (HP:0003678)1.85357696
117Menstrual irregularities (HP:0000858)1.85133203
118Hyperventilation (HP:0002883)1.82223507
119Neoplasm of the peripheral nervous system (HP:0100007)1.81809235
120Hyperthyroidism (HP:0000836)1.79301851
121Impaired vibratory sensation (HP:0002495)1.78877054
122Generalized myoclonic seizures (HP:0002123)1.78641375
123Elfin facies (HP:0004428)1.78340529
124Abnormality of saccadic eye movements (HP:0000570)1.76619346
125Macroorchidism (HP:0000053)1.76044421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.82863915
2NTRK33.81598216
3MARK13.47704791
4EPHA43.03973824
5MINK12.67920344
6DAPK22.58405717
7NTRK22.58341694
8PAK62.52879588
9MAP3K42.48959108
10PRKD32.43440243
11CAMKK12.31578892
12WNK32.20152966
13NTRK12.10580460
14KSR11.95022207
15KSR21.85513959
16CAMKK21.81805883
17UHMK11.81317831
18MAP2K71.75527122
19CDK51.67511540
20CDK191.64907143
21MAP2K41.54220982
22TYRO31.45792228
23PRPF4B1.41637893
24STK381.37345861
25DAPK11.31631967
26GRK51.26507944
27SIK21.25025312
28MAPK131.21235826
29RIPK41.19706282
30TNIK1.18816939
31PRKCG1.15592430
32CDK181.14141962
33RIPK11.13461111
34EPHB21.12081046
35CDK151.11928780
36PHKG21.11500557
37PHKG11.11500557
38MAP3K121.11121147
39ALK1.09036501
40PNCK1.07927227
41LMTK21.05760911
42CDK141.03321639
43ICK1.02517625
44FES1.02222060
45STK111.01021081
46CDK11A0.99798835
47RET0.98910911
48CAMK10.96688405
49PRKCH0.95955105
50FGFR20.95588887
51PAK30.92290912
52TAOK10.91913364
53PLK20.89851928
54NEK10.89539876
55LATS20.86938789
56PINK10.85315760
57MARK20.84237864
58MAP3K20.82226124
59CAMK2A0.77642057
60MAPK120.76170597
61SGK2230.75247137
62SGK4940.75247137
63CASK0.74512864
64CAMK1G0.73765185
65BRSK10.69922865
66CSNK1G20.69334918
67BCR0.69131064
68CAMK2B0.68587881
69CDC42BPA0.68177539
70PKN10.67691967
71WNK10.66871843
72TESK10.66774798
73BMPR20.66774193
74ARAF0.65478917
75DYRK1A0.65191474
76CAMK40.62750639
77OXSR10.56324779
78PRKCZ0.56096072
79FYN0.54960338
80LIMK10.54449898
81SGK10.54156850
82IRAK20.53509924
83TRIB30.52666492
84SIK30.52260261
85RPS6KA30.52034746
86BRAF0.50860027
87ERBB20.50066821
88PDPK10.49502968
89FER0.48722548
90MAP3K130.48408127
91PDGFRA0.48308291
92SCYL20.48291145
93DAPK30.47712010
94SGK30.46682848
95PDK10.46049897
96MAP3K10.46031283
97HIPK20.45851819
98ERBB30.45056948
99PTK20.44482601
100CAMK2G0.44139933
101SGK20.43308848
102CAMK2D0.43297171
103ROCK20.41894287
104MAPK100.41649035
105MAP2K60.41444891
106RPS6KA20.40154530
107NEK60.39971153
108TNK20.39116849
109PASK0.39027039
110MAP3K110.38376931
111ROCK10.37432446
112PRKCA0.35279136
113PRKCE0.31320114
114PRKG20.30563601
115RAF10.29170750
116PRKACA0.28199444
117MAPK80.27627314
118PRKAA10.26323102

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66229718
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29883968
3GABAergic synapse_Homo sapiens_hsa047272.70032255
4Circadian entrainment_Homo sapiens_hsa047132.60238247
5Glutamatergic synapse_Homo sapiens_hsa047242.54418294
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48687752
7Long-term potentiation_Homo sapiens_hsa047202.45425565
8Olfactory transduction_Homo sapiens_hsa047402.42838011
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37494474
10Morphine addiction_Homo sapiens_hsa050322.37429458
11Amphetamine addiction_Homo sapiens_hsa050312.29048329
12Insulin secretion_Homo sapiens_hsa049112.18297409
13Dopaminergic synapse_Homo sapiens_hsa047282.08002507
14Salivary secretion_Homo sapiens_hsa049702.06125878
15Cholinergic synapse_Homo sapiens_hsa047251.92992118
16Gastric acid secretion_Homo sapiens_hsa049711.85445290
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83979196
18Cocaine addiction_Homo sapiens_hsa050301.78864950
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77692263
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75092331
21Long-term depression_Homo sapiens_hsa047301.73784014
22Taste transduction_Homo sapiens_hsa047421.72145853
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64660094
24Renin secretion_Homo sapiens_hsa049241.53145195
25Type II diabetes mellitus_Homo sapiens_hsa049301.46526678
26Gap junction_Homo sapiens_hsa045401.46307675
27Serotonergic synapse_Homo sapiens_hsa047261.43988110
28GnRH signaling pathway_Homo sapiens_hsa049121.40431727
29Vitamin B6 metabolism_Homo sapiens_hsa007501.39723748
30Calcium signaling pathway_Homo sapiens_hsa040201.38059011
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35258978
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28441396
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28210725
34Axon guidance_Homo sapiens_hsa043601.27070383
35Estrogen signaling pathway_Homo sapiens_hsa049151.26521513
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19217700
37cAMP signaling pathway_Homo sapiens_hsa040241.19126141
38Nitrogen metabolism_Homo sapiens_hsa009101.14315773
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10720279
40Cardiac muscle contraction_Homo sapiens_hsa042601.09916856
41Glioma_Homo sapiens_hsa052141.07426054
42Melanogenesis_Homo sapiens_hsa049161.07412416
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.06846576
44Collecting duct acid secretion_Homo sapiens_hsa049661.02789004
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00153446
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95465750
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.94822390
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94383734
49ErbB signaling pathway_Homo sapiens_hsa040120.93338448
50Pancreatic secretion_Homo sapiens_hsa049720.92249168
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92091240
52Oocyte meiosis_Homo sapiens_hsa041140.89439645
53Thyroid hormone synthesis_Homo sapiens_hsa049180.85598684
54Vibrio cholerae infection_Homo sapiens_hsa051100.85203271
55Dilated cardiomyopathy_Homo sapiens_hsa054140.83720703
56Dorso-ventral axis formation_Homo sapiens_hsa043200.83268320
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81018120
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.80711967
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.78692465
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76592521
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74697291
62mTOR signaling pathway_Homo sapiens_hsa041500.72211037
63Choline metabolism in cancer_Homo sapiens_hsa052310.69245502
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69043372
65Type I diabetes mellitus_Homo sapiens_hsa049400.67276089
66MAPK signaling pathway_Homo sapiens_hsa040100.65936363
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64429882
68Alcoholism_Homo sapiens_hsa050340.63889324
69Bile secretion_Homo sapiens_hsa049760.62448450
70VEGF signaling pathway_Homo sapiens_hsa043700.60933849
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58970607
72Endometrial cancer_Homo sapiens_hsa052130.58878963
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57888365
74Glucagon signaling pathway_Homo sapiens_hsa049220.56598165
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56518170
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56158618
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55696043
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55689654
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55113668
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54943285
81Endocytosis_Homo sapiens_hsa041440.53511811
82Insulin signaling pathway_Homo sapiens_hsa049100.50971142
83Rap1 signaling pathway_Homo sapiens_hsa040150.50813831
84Prion diseases_Homo sapiens_hsa050200.50600194
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.49600453
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49197506
87Phototransduction_Homo sapiens_hsa047440.47383456
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46777447
89Butanoate metabolism_Homo sapiens_hsa006500.46101836
90Ras signaling pathway_Homo sapiens_hsa040140.45904322
91Non-small cell lung cancer_Homo sapiens_hsa052230.45467033
92Inositol phosphate metabolism_Homo sapiens_hsa005620.45136202
93Arginine and proline metabolism_Homo sapiens_hsa003300.45092456
94Renal cell carcinoma_Homo sapiens_hsa052110.44946672
95Wnt signaling pathway_Homo sapiens_hsa043100.41265530
96Ovarian steroidogenesis_Homo sapiens_hsa049130.40395254
97Mineral absorption_Homo sapiens_hsa049780.35538084
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34228262
99Chemokine signaling pathway_Homo sapiens_hsa040620.33810878
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33246087
101Alzheimers disease_Homo sapiens_hsa050100.33136225
102Circadian rhythm_Homo sapiens_hsa047100.32462571
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32155988
104Arginine biosynthesis_Homo sapiens_hsa002200.30922809
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30831321
106Prolactin signaling pathway_Homo sapiens_hsa049170.30773945
107Hedgehog signaling pathway_Homo sapiens_hsa043400.30712529
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.30434881
109beta-Alanine metabolism_Homo sapiens_hsa004100.30182120
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29929976
111Regulation of autophagy_Homo sapiens_hsa041400.28787853
112Colorectal cancer_Homo sapiens_hsa052100.27965472
113AMPK signaling pathway_Homo sapiens_hsa041520.27013270
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26291858
115Fatty acid biosynthesis_Homo sapiens_hsa000610.23466441
116Histidine metabolism_Homo sapiens_hsa003400.21859590
117ABC transporters_Homo sapiens_hsa020100.19236402
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19045032

Most similar genes based on co-expression Upload to Enrichr

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