CDH23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)8.34261977
2sex determination (GO:0007530)7.86288200
3regulation of male gonad development (GO:2000018)7.27768161
4piRNA metabolic process (GO:0034587)7.25636609
5fusion of sperm to egg plasma membrane (GO:0007342)7.16849841
6regulation of meiosis I (GO:0060631)7.00111211
7synaptonemal complex assembly (GO:0007130)5.96840813
8male sex determination (GO:0030238)5.82507384
9synaptonemal complex organization (GO:0070193)5.70184719
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.44361471
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.44361471
12modulation by symbiont of host immune response (GO:0052553)5.44361471
13positive regulation by symbiont of host defense response (GO:0052509)5.44361471
14modulation by symbiont of host defense response (GO:0052031)5.44361471
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.44361471
16plasma membrane fusion (GO:0045026)5.33773949
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.32800850
18male meiosis (GO:0007140)5.25178913
19antigen processing and presentation of endogenous antigen (GO:0019883)5.17742899
20DNA methylation involved in gamete generation (GO:0043046)5.11750271
21neutrophil activation involved in immune response (GO:0002283)5.05080777
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00366782
23sex differentiation (GO:0007548)5.00354084
24macrophage activation involved in immune response (GO:0002281)4.89042984
25erythrocyte maturation (GO:0043249)4.76676009
26oocyte development (GO:0048599)4.62228688
27antigen processing and presentation via MHC class Ib (GO:0002475)4.58309821
28detection of other organism (GO:0098543)4.48545911
29regulation of gamma-delta T cell activation (GO:0046643)4.46550206
30regulation of gonadotropin secretion (GO:0032276)4.42182739
31cellular extravasation (GO:0045123)4.38963802
32response to peptidoglycan (GO:0032494)4.34391971
33glomerular basement membrane development (GO:0032836)4.30848848
34anatomical structure regression (GO:0060033)4.22889014
35detection of bacterium (GO:0016045)4.20189546
36detection of molecule of bacterial origin (GO:0032490)4.16825850
37male meiosis I (GO:0007141)4.15312618
38negative regulation of interleukin-12 production (GO:0032695)4.09805610
39regulation of B cell receptor signaling pathway (GO:0050855)4.07910336
40Leydig cell differentiation (GO:0033327)4.00677384
41detection of external biotic stimulus (GO:0098581)3.99626592
42leukocyte aggregation (GO:0070486)3.92986635
43regulation of interferon-beta biosynthetic process (GO:0045357)3.86097910
44germ cell migration (GO:0008354)3.81081701
45macroautophagy (GO:0016236)3.78734921
46positive regulation of mast cell activation (GO:0033005)3.77254392
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.75007633
48immunoglobulin mediated immune response (GO:0016064)3.74589938
49fat-soluble vitamin biosynthetic process (GO:0042362)3.72140742
50positive regulation of B cell differentiation (GO:0045579)3.68709376
51chromosome organization involved in meiosis (GO:0070192)3.66686957
52seminiferous tubule development (GO:0072520)3.63748783
53apoptotic cell clearance (GO:0043277)3.63425356
54detection of biotic stimulus (GO:0009595)3.62486805
55macrophage activation (GO:0042116)3.62245306
56neutrophil activation (GO:0042119)3.62038538
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55774831
58meiotic nuclear division (GO:0007126)3.55345630
59spermatid development (GO:0007286)3.55044162
60leukocyte migration involved in inflammatory response (GO:0002523)3.54977541
61regulation of female gonad development (GO:2000194)3.52937526
62natural killer cell differentiation (GO:0001779)3.52884979
63acrosome assembly (GO:0001675)3.51125611
64sperm motility (GO:0030317)3.51077898
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50665320
66positive thymic T cell selection (GO:0045059)3.47706914
67myeloid cell activation involved in immune response (GO:0002275)3.47471524
68myelin assembly (GO:0032288)3.46775567
69ovulation cycle (GO:0042698)3.45790663
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45396481
71response to host immune response (GO:0052572)3.44102704
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44102704
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.43295491
74regulation of mast cell degranulation (GO:0043304)3.42316637
75fibroblast migration (GO:0010761)3.40667052
76positive regulation of antigen processing and presentation (GO:0002579)3.39915104
77poly(A)+ mRNA export from nucleus (GO:0016973)3.37975168
78respiratory burst (GO:0045730)3.35699979
79negative regulation of T cell mediated immunity (GO:0002710)3.35665432
80granulocyte activation (GO:0036230)3.33878599
81positive regulation of meiosis (GO:0045836)3.32902415
82negative regulation of organelle assembly (GO:1902116)3.30806785
83negative regulation of leukocyte mediated immunity (GO:0002704)3.29364742
84negative regulation of macrophage differentiation (GO:0045650)3.29260307
85histone H3-K36 demethylation (GO:0070544)3.29200618
86regulation of tolerance induction (GO:0002643)3.28194091
87germ cell development (GO:0007281)3.27486478
88neutrophil mediated immunity (GO:0002446)3.27383702
89response to muramyl dipeptide (GO:0032495)3.26906911
90hematopoietic stem cell differentiation (GO:0060218)3.26376392
91positive regulation of mast cell degranulation (GO:0043306)3.24101143
92positive regulation of mast cell activation involved in immune response (GO:0033008)3.24101143
93activated T cell proliferation (GO:0050798)3.23819894
94regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23422004
95T cell migration (GO:0072678)3.21770339
96negative regulation of meiosis (GO:0045835)3.20563312
97negative regulation of cell killing (GO:0031342)3.20557488
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20557488
99regulation of mast cell activation involved in immune response (GO:0033006)3.19106380
100regulation of T cell tolerance induction (GO:0002664)3.17490470
101response to host (GO:0075136)3.13697270
102response to host defenses (GO:0052200)3.13697270
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13697270
104cellular process involved in reproduction in multicellular organism (GO:0022412)3.12117634
105gene silencing by RNA (GO:0031047)3.11642231
106negative thymic T cell selection (GO:0045060)3.08742083
107cilium or flagellum-dependent cell motility (GO:0001539)3.08136162
108regulation of leukocyte degranulation (GO:0043300)3.06668442
109negative regulation of granulocyte differentiation (GO:0030853)3.04124744
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04018432
111positive regulation of meiotic cell cycle (GO:0051446)3.04018425
112meiosis I (GO:0007127)3.03955206
113regulation of mast cell activation (GO:0033003)3.03726397
114response to interleukin-15 (GO:0070672)3.03339157
115negative T cell selection (GO:0043383)3.02657568
116hair cell differentiation (GO:0035315)3.01667842
117regulation of antigen processing and presentation (GO:0002577)3.01614673
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01375952
119positive regulation of tolerance induction (GO:0002645)2.97921414
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96162381
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.94814494
122negative regulation of interleukin-6 production (GO:0032715)2.93882599
123T cell selection (GO:0045058)2.93171070
124nuclear pore complex assembly (GO:0051292)2.89957967
125germinal center formation (GO:0002467)2.88745679
126I-kappaB phosphorylation (GO:0007252)2.87343967
127myeloid leukocyte mediated immunity (GO:0002444)2.86886846
128negative regulation of cytokine production involved in immune response (GO:0002719)2.85688022
129spinal cord development (GO:0021510)2.85116624
130B cell receptor signaling pathway (GO:0050853)2.85083051
131positive regulation of cellular amide metabolic process (GO:0034250)2.84779392
132microglial cell activation (GO:0001774)2.84079097
133positive regulation of natural killer cell differentiation (GO:0032825)2.83979940
134type I interferon signaling pathway (GO:0060337)2.82667883
135cellular response to type I interferon (GO:0071357)2.82667883
136spermatogenesis (GO:0007283)2.82550186
137regulation of T-helper 2 cell differentiation (GO:0045628)2.82531362
138response to type I interferon (GO:0034340)2.82289918
139male gamete generation (GO:0048232)2.81013161
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80794192
141cellular response to interleukin-15 (GO:0071350)2.76420626
142negative regulation of catenin import into nucleus (GO:0035414)2.75487687
143regulation of protein polyubiquitination (GO:1902914)2.74701396
144positive regulation of macrophage cytokine production (GO:0060907)2.73919521
145regulation of B cell differentiation (GO:0045577)2.73642857
146negative regulation of erythrocyte differentiation (GO:0045647)2.73406362
147positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72882467
148negative regulation of type 2 immune response (GO:0002829)2.72613518
149regulation of macrophage cytokine production (GO:0010935)2.72320450
150cardiac myofibril assembly (GO:0055003)2.71542889
151B cell mediated immunity (GO:0019724)2.69544415
152lysosome localization (GO:0032418)2.69458411
153astrocyte development (GO:0014002)2.68623964
154positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67401849
155neutrophil chemotaxis (GO:0030593)2.66556967
156negative regulation of innate immune response (GO:0045824)2.64544038
157oogenesis (GO:0048477)2.64342541
158defense response to protozoan (GO:0042832)2.63354556
159thymic T cell selection (GO:0045061)2.60243515
160regulation of regulated secretory pathway (GO:1903305)2.60203506
161vagina development (GO:0060068)2.59914290
162leukocyte degranulation (GO:0043299)2.59799638
163positive regulation of reproductive process (GO:2000243)2.59427884
164DNA methylation (GO:0006306)2.58665910
165DNA alkylation (GO:0006305)2.58665910
166gamete generation (GO:0007276)2.58494847
167regulation of gamma-delta T cell differentiation (GO:0045586)2.56563599
168negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.56444148
169female genitalia development (GO:0030540)2.55416366
170glial cell proliferation (GO:0014009)2.54109860
171regulation of skeletal muscle contraction (GO:0014819)2.54098754
172acrosome reaction (GO:0007340)2.52158885
173positive T cell selection (GO:0043368)2.51474069
174female gonad development (GO:0008585)2.48887805
175mitochondrial calcium ion transport (GO:0006851)2.47483747
176diaphragm development (GO:0060539)2.47257144
177histone H3-K9 demethylation (GO:0033169)2.46682527
178gene silencing (GO:0016458)2.44933377
179female gamete generation (GO:0007292)2.43416194
180positive regulation of gamma-delta T cell activation (GO:0046645)2.40685426
181positive regulation of myotube differentiation (GO:0010831)2.39250588
182regulation of chromatin binding (GO:0035561)2.38453845
183response to misfolded protein (GO:0051788)2.37410616
184Sertoli cell development (GO:0060009)2.37051957
185cellular response to heat (GO:0034605)2.36750006
186mannose metabolic process (GO:0006013)2.36255311
187sperm-egg recognition (GO:0035036)2.36086017
188gonadal mesoderm development (GO:0007506)11.1763367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.28566313
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.47206329
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.35178525
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89638476
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79588134
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40460788
7TCF7_22412390_ChIP-Seq_EML_Mouse2.38408045
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34337124
9KDM2B_26808549_Chip-Seq_DND41_Human2.26045772
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12777981
11* SCL_19346495_ChIP-Seq_HPC-7_Human2.02886305
12KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97891042
13EGR1_19374776_ChIP-ChIP_THP-1_Human1.83138463
14* IRF8_27001747_Chip-Seq_BMDM_Mouse1.77084136
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76433241
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76186883
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75512938
18MAF_26560356_Chip-Seq_TH1_Human1.66018483
19PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64193262
20SPI1_23547873_ChIP-Seq_NB4_Human1.63246133
21TP53_22127205_ChIP-Seq_IMR90_Human1.63165369
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62822731
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.61127230
24UTX_26944678_Chip-Seq_JUKART_Human1.59957153
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59841365
26DROSHA_22980978_ChIP-Seq_HELA_Human1.59281113
27RUNX_20019798_ChIP-Seq_JUKART_Human1.58972740
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54811685
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.53584840
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.53584840
31KDM2B_26808549_Chip-Seq_K562_Human1.49792567
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49755057
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49556865
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49417793
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46518811
36FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.45525789
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.40233567
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39640984
39SPI1_23127762_ChIP-Seq_K562_Human1.38312742
40VDR_21846776_ChIP-Seq_THP-1_Human1.36675195
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36005107
42* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35634266
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.35113503
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33659846
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32808303
46LXR_22292898_ChIP-Seq_THP-1_Human1.32658969
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.31524191
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30245326
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.28209334
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.27617684
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24683334
52CLOCK_20551151_ChIP-Seq_293T_Human1.23929935
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23239779
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.23236392
55MYC_22102868_ChIP-Seq_BL_Human1.22824810
56MYB_26560356_Chip-Seq_TH1_Human1.21850718
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21264075
58MYB_26560356_Chip-Seq_TH2_Human1.20903768
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20899137
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20702523
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19538408
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19538408
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19538408
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.17395656
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15065175
66* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14178678
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14036688
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13292603
69SPI1_20517297_ChIP-Seq_HL60_Human1.12183065
70PU_27001747_Chip-Seq_BMDM_Mouse1.09069249
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08533110
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07879425
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06957786
74GATA1_22025678_ChIP-Seq_K562_Human1.06826281
75GATA3_27048872_Chip-Seq_THYMUS_Human1.06654484
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06620635
77NCOR1_26117541_ChIP-Seq_K562_Human1.06081816
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04826562
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04747793
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.04621079
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04079767
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03814103
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03794949
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02454594
85* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99869929
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99788584
87RUNX1_22412390_ChIP-Seq_EML_Mouse0.99540371
88SMC4_20622854_ChIP-Seq_HELA_Human0.98879262
89EZH2_22144423_ChIP-Seq_EOC_Human0.98801243
90* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98154220
91ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96837772
92STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96746110
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.96393525
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96227177
95BCL6_27268052_Chip-Seq_Bcells_Human0.96165224
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96018694
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95958389
98RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95749448
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95529336
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95460509
101OCT4_19829295_ChIP-Seq_ESCs_Human0.95426416
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95028709
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93884766
104STAT1_20625510_ChIP-Seq_HELA_Human0.93797737
105FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93749427
106* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93164226
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93098394
108GATA1_19941826_ChIP-Seq_K562_Human0.92372775
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91816444
110* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91753223
111VDR_24763502_ChIP-Seq_THP-1_Human0.91700027
112RACK7_27058665_Chip-Seq_MCF-7_Human0.91392467
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91186212
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90891051
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90606856
116CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89766636
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.88989163
118GATA3_26560356_Chip-Seq_TH2_Human0.88873748
119* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88023453
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87427710
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87333519
122GATA2_19941826_ChIP-Seq_K562_Human0.86453973
123MAF_26560356_Chip-Seq_TH2_Human0.86191490
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85871806
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84785487
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84672680
127VDR_24787735_ChIP-Seq_THP-1_Human0.84415676
128BCOR_27268052_Chip-Seq_Bcells_Human0.82319475
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80188098
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80177603
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77722422
132* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77214796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.27388096
2MP0008877_abnormal_DNA_methylation4.96594983
3MP0005410_abnormal_fertilization4.31431364
4MP0009278_abnormal_bone_marrow3.15263818
5MP0003786_premature_aging3.10305535
6MP0003045_fibrosis2.83254146
7MP0000013_abnormal_adipose_tissue2.82936668
8MP0000569_abnormal_digit_pigmentation2.74987043
9MP0005025_abnormal_response_to2.68806950
10MP0001790_abnormal_immune_system2.68037206
11MP0005387_immune_system_phenotype2.68037206
12MP0003172_abnormal_lysosome_physiology2.45673749
13MP0009785_altered_susceptibility_to2.32436013
14MP0001929_abnormal_gametogenesis2.30664553
15MP0000751_myopathy2.29908629
16MP0002210_abnormal_sex_determination2.26931434
17MP0005670_abnormal_white_adipose2.24361792
18MP0003698_abnormal_male_reproductive2.14446890
19MP0010307_abnormal_tumor_latency2.06951197
20MP0001145_abnormal_male_reproductive2.05026751
21MP0004084_abnormal_cardiac_muscle2.00677385
22MP0002277_abnormal_respiratory_mucosa2.00298970
23* MP0003878_abnormal_ear_physiology2.00091677
24* MP0005377_hearing/vestibular/ear_phenot2.00091677
25MP0003191_abnormal_cellular_cholesterol1.97623170
26MP0005647_abnormal_sex_gland1.93956903
27MP0002132_abnormal_respiratory_system1.91812108
28MP0003300_gastrointestinal_ulcer1.85783590
29MP0005623_abnormal_meninges_morphology1.83633378
30MP0001661_extended_life_span1.81183244
31MP0008260_abnormal_autophagy1.79089597
32MP0003690_abnormal_glial_cell1.75510707
33MP0005167_abnormal_blood-brain_barrier1.73543307
34MP0005058_abnormal_lysosome_morphology1.68886875
35MP0006138_congestive_heart_failure1.64907513
36MP0000653_abnormal_sex_gland1.64119882
37MP0004381_abnormal_hair_follicle1.61765745
38MP0005248_abnormal_Harderian_gland1.59030038
39MP0005076_abnormal_cell_differentiation1.57861215
40MP0001958_emphysema1.57493768
41MP0004130_abnormal_muscle_cell1.53707411
42MP0002998_abnormal_bone_remodeling1.50758519
43MP0001845_abnormal_inflammatory_respons1.50265199
44MP0000003_abnormal_adipose_tissue1.46451124
45MP0003828_pulmonary_edema1.43196085
46MP0009764_decreased_sensitivity_to1.42383900
47MP0001727_abnormal_embryo_implantation1.40739457
48MP0003195_calcinosis1.38441283
49MP0004808_abnormal_hematopoietic_stem1.38409446
50MP0010155_abnormal_intestine_physiology1.38147290
51MP0004036_abnormal_muscle_relaxation1.37223345
52MP0005451_abnormal_body_composition1.36746132
53MP0001835_abnormal_antigen_presentation1.34664845
54MP0009384_cardiac_valve_regurgitation1.34520561
55MP0002168_other_aberrant_phenotype1.31358273
56MP0001851_eye_inflammation1.29054490
57MP0008004_abnormal_stomach_pH1.28097448
58MP0001853_heart_inflammation1.27222349
59* MP0003879_abnormal_hair_cell1.27177461
60MP0003303_peritoneal_inflammation1.26943441
61MP0005375_adipose_tissue_phenotype1.24582254
62MP0000604_amyloidosis1.24009635
63MP0003075_altered_response_to1.23154242
64MP0002722_abnormal_immune_system1.22769076
65MP0009333_abnormal_splenocyte_physiolog1.21610105
66MP0005397_hematopoietic_system_phenotyp1.20866891
67MP0001545_abnormal_hematopoietic_system1.20866891
68MP0004883_abnormal_blood_vessel1.19188846
69MP0008469_abnormal_protein_level1.19186686
70MP0002429_abnormal_blood_cell1.18405996
71MP0003646_muscle_fatigue1.18044617
72MP0002653_abnormal_ependyma_morphology1.17952574
73MP0003091_abnormal_cell_migration1.17800523
74MP0002166_altered_tumor_susceptibility1.17025870
75MP0002938_white_spotting1.14917382
76MP0004510_myositis1.09760458
77MP0005671_abnormal_response_to1.09199879
78MP0000685_abnormal_immune_system1.08892174
79MP0002332_abnormal_exercise_endurance1.08783733
80MP0000465_gastrointestinal_hemorrhage1.07951811
81MP0006082_CNS_inflammation1.07461601
82MP0003763_abnormal_thymus_physiology1.06563716
83* MP0002161_abnormal_fertility/fecundity1.05365871
84MP0004272_abnormal_basement_membrane1.03521200
85MP0005310_abnormal_salivary_gland1.01871066
86MP0003936_abnormal_reproductive_system1.00581807
87MP0001873_stomach_inflammation1.00264628
88MP0003183_abnormal_peptide_metabolism0.99846993
89MP0005166_decreased_susceptibility_to0.98952926
90MP0003279_aneurysm0.97612732
91MP0003115_abnormal_respiratory_system0.97212939
92MP0010630_abnormal_cardiac_muscle0.94626623
93MP0001819_abnormal_immune_cell0.94560769
94MP0002452_abnormal_antigen_presenting0.94239900
95MP0002420_abnormal_adaptive_immunity0.93167564
96MP0005666_abnormal_adipose_tissue0.92724084
97MP0001986_abnormal_taste_sensitivity0.92374156
98MP0004947_skin_inflammation0.92111284
99MP0000858_altered_metastatic_potential0.91570444
100MP0001800_abnormal_humoral_immune0.91545865
101MP0005390_skeleton_phenotype0.90373753
102MP0003656_abnormal_erythrocyte_physiolo0.89501324
103MP0003011_delayed_dark_adaptation0.89429347
104MP0002837_dystrophic_cardiac_calcinosis0.86947393
105MP0008438_abnormal_cutaneous_collagen0.86531474
106MP0003724_increased_susceptibility_to0.85084119
107MP0002396_abnormal_hematopoietic_system0.84563043
108MP0002160_abnormal_reproductive_system0.83603437
109MP0000343_altered_response_to0.82867330
110MP0005464_abnormal_platelet_physiology0.82515303
111MP0003436_decreased_susceptibility_to0.82457315
112MP0002405_respiratory_system_inflammati0.82138017
113MP0003329_amyloid_beta_deposits0.80890312
114MP0002148_abnormal_hypersensitivity_rea0.80676276
115MP0002723_abnormal_immune_serum0.79423039
116MP0009115_abnormal_fat_cell0.79207334
117MP0004087_abnormal_muscle_fiber0.79151394
118MP0003315_abnormal_perineum_morphology0.78477413
119MP0002398_abnormal_bone_marrow0.78404677
120MP0002419_abnormal_innate_immunity0.77507293
121MP0002138_abnormal_hepatobiliary_system0.76561090
122MP0000733_abnormal_muscle_development0.75533127
123MP0005164_abnormal_response_to0.74842559
124MP0002128_abnormal_blood_circulation0.74734430
125MP0008961_abnormal_basal_metabolism0.74241093
126MP0003448_altered_tumor_morphology0.73632800
127MP0002106_abnormal_muscle_physiology0.72810767
128MP0005535_abnormal_body_temperature0.71670084
129MP0000249_abnormal_blood_vessel0.71624245
130MP0001663_abnormal_digestive_system0.71537891
131MP0008874_decreased_physiological_sensi0.70408094
132MP0003705_abnormal_hypodermis_morpholog0.70229200
133MP0002133_abnormal_respiratory_system0.69941658
134MP0005388_respiratory_system_phenotype0.69941658
135MP0008058_abnormal_DNA_repair0.69863247
136MP0002006_tumorigenesis0.69733867
137MP0002971_abnormal_brown_adipose0.68542199
138MP0002933_joint_inflammation0.68075747
139MP0004145_abnormal_muscle_electrophysio0.67974284
140MP0004185_abnormal_adipocyte_glucose0.67640028
141MP0000767_abnormal_smooth_muscle0.67095515
142MP0000716_abnormal_immune_system0.66497970
143MP0004147_increased_porphyrin_level0.66189286
144MP0000689_abnormal_spleen_morphology0.65743711
145MP0005000_abnormal_immune_tolerance0.65502801
146MP0000703_abnormal_thymus_morphology0.65340654
147MP0003787_abnormal_imprinting0.65159018
148* MP0003866_abnormal_defecation0.65108080
149MP0000639_abnormal_adrenal_gland0.64135741
150MP0005334_abnormal_fat_pad0.63076929
151MP0001533_abnormal_skeleton_physiology0.62650528
152MP0003795_abnormal_bone_structure0.62398908
153MP0000920_abnormal_myelination0.61298288

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.82752175
2Gonadal dysgenesis (HP:0000133)6.75547195
3Eczematoid dermatitis (HP:0000976)5.99168791
4Recurrent bacterial skin infections (HP:0005406)5.43621686
5Recurrent abscess formation (HP:0002722)5.38930153
6Gonadotropin excess (HP:0000837)5.31680553
7Abnormality of macrophages (HP:0004311)5.23194976
8Recurrent gram-negative bacterial infections (HP:0005420)4.94342642
9Elevated erythrocyte sedimentation rate (HP:0003565)4.90514379
10Myositis (HP:0100614)4.72498096
11Male pseudohermaphroditism (HP:0000037)4.48559071
12Orchitis (HP:0100796)4.41412704
13Infertility (HP:0000789)4.39641189
14Optic neuritis (HP:0100653)4.33050928
15Retrobulbar optic neuritis (HP:0100654)4.33050928
16Facial diplegia (HP:0001349)4.29650453
17Entropion (HP:0000621)4.23185551
18Testicular neoplasm (HP:0010788)4.10000107
19Azoospermia (HP:0000027)4.02471636
20Stomatitis (HP:0010280)3.99441557
21Abnormal sex determination (HP:0012244)3.92246894
22Sex reversal (HP:0012245)3.92246894
23Poikiloderma (HP:0001029)3.80020298
24Hand muscle atrophy (HP:0009130)3.71848809
25Spontaneous hematomas (HP:0007420)3.68256888
26Mesangial abnormality (HP:0001966)3.62844106
27Chronic obstructive pulmonary disease (HP:0006510)3.54774256
28Obstructive lung disease (HP:0006536)3.54774256
29Gingivitis (HP:0000230)3.47586708
30Gastrointestinal infarctions (HP:0005244)3.45010144
31Recurrent fungal infections (HP:0002841)3.42244173
32Absent/shortened dynein arms (HP:0200106)3.39435902
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.39435902
34Abnormal spermatogenesis (HP:0008669)3.38548913
35Meningitis (HP:0001287)3.36581641
36Cerebral aneurysm (HP:0004944)3.35804654
37Recurrent skin infections (HP:0001581)3.35634014
38Abnormality of male internal genitalia (HP:0000022)3.29861998
39Keratoconjunctivitis sicca (HP:0001097)3.24213151
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22221938
41Increased cerebral lipofuscin (HP:0011813)3.19923437
42Chronic otitis media (HP:0000389)3.15895290
43Abnormality of liposaccharide metabolism (HP:0010968)3.15767557
44Abnormality of glycosphingolipid metabolism (HP:0004343)3.15767557
45Abnormality of glycolipid metabolism (HP:0010969)3.15767557
46Germ cell neoplasia (HP:0100728)3.12285174
47Prolonged bleeding time (HP:0003010)3.11834644
48Encephalitis (HP:0002383)3.11739994
4911 pairs of ribs (HP:0000878)3.11615923
50Nasal polyposis (HP:0100582)3.08400589
51Abnormality of DNA repair (HP:0003254)3.07711668
52Distal upper limb amyotrophy (HP:0007149)3.00578339
53Upper limb amyotrophy (HP:0009129)3.00578339
54Chronic mucocutaneous candidiasis (HP:0002728)2.96398501
55Recurrent cutaneous fungal infections (HP:0011370)2.96398501
56Keratoconjunctivitis (HP:0001096)2.93613261
57Subacute progressive viral hepatitis (HP:0006572)2.89594482
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.84354832
59Abnormality of the nasal mucosa (HP:0000433)2.82507999
60Vasculitis (HP:0002633)2.79017936
61Metaphyseal cupping (HP:0003021)2.75660370
62Gingival bleeding (HP:0000225)2.74286638
63Hemoptysis (HP:0002105)2.71166694
64T lymphocytopenia (HP:0005403)2.69451391
65Ankle clonus (HP:0011448)2.68943677
66Hypochromic microcytic anemia (HP:0004840)2.68081570
67Increased IgE level (HP:0003212)2.65909471
68Ankle contracture (HP:0006466)2.64027721
69Chest pain (HP:0100749)2.63028788
70Purpura (HP:0000979)2.59451268
71Inflammation of the large intestine (HP:0002037)2.58591857
72Amyloidosis (HP:0011034)2.57149416
73Epistaxis (HP:0000421)2.54984227
74Pulmonary infiltrates (HP:0002113)2.53464929
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.52748400
76Cellulitis (HP:0100658)2.51937230
77Aortic aneurysm (HP:0004942)2.50744850
78Gastrointestinal inflammation (HP:0004386)2.49421184
79Urticaria (HP:0001025)2.49040107
80Hyporeflexia of lower limbs (HP:0002600)2.48564189
81Rectal prolapse (HP:0002035)2.48271553
82Decreased subcutaneous fat (HP:0001002)2.46408316
83Abnormality of T cell number (HP:0011839)2.46285413
84Pulmonary embolism (HP:0002204)2.43197767
85Systemic lupus erythematosus (HP:0002725)2.43109633
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40177995
87Leukocytosis (HP:0001974)2.39216148
88Hyperacusis (HP:0010780)2.32403391
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30929289
90Prominent metopic ridge (HP:0005487)2.30167503
91Aortic dissection (HP:0002647)2.29429806
92Arterial thrombosis (HP:0004420)2.28038301
93Peritonitis (HP:0002586)2.27487277
94Hypoplasia of the uterus (HP:0000013)2.27294231
95Hypochromic anemia (HP:0001931)2.26965577
96Bladder diverticulum (HP:0000015)2.26107975
97Episodic fever (HP:0001954)2.24239896
98Microcytic anemia (HP:0001935)2.23713821
99Glomerulonephritis (HP:0000099)2.23684713
100Increased IgM level (HP:0003496)2.22122135
101Vacuolated lymphocytes (HP:0001922)2.21553548
102Fragile nails (HP:0001808)2.20891243
103Stridor (HP:0010307)2.18738705
104Loss of speech (HP:0002371)2.15285196
105Abnormality of the fingertips (HP:0001211)2.14603806
106Renovascular hypertension (HP:0100817)2.14494314
107Dysostosis multiplex (HP:0000943)2.13401269
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13224587
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12979110
110Stage 5 chronic kidney disease (HP:0003774)2.12673406
111Hemiplegia (HP:0002301)2.12566855
112Diaphragmatic weakness (HP:0009113)2.12534447
113Pustule (HP:0200039)2.12226694
114Abnormality of the musculature of the hand (HP:0001421)2.11890739
115Obstructive sleep apnea (HP:0002870)2.10202500
116Petechiae (HP:0000967)2.08711680
117Myopathic facies (HP:0002058)2.08229358
118Muscle fibrillation (HP:0010546)2.06488579
119Pulmonary fibrosis (HP:0002206)2.05854208
120Difficulty running (HP:0009046)2.04410529
121Elfin facies (HP:0004428)2.04369155
122Recurrent bronchitis (HP:0002837)2.03274766
123Hypergammaglobulinemia (HP:0010702)2.03167041
124Acne (HP:0001061)2.03138287
125Recurrent viral infections (HP:0004429)2.02479702
126Disinhibition (HP:0000734)2.02301629
127Anorexia (HP:0002039)2.01165124
128Exercise-induced myalgia (HP:0003738)2.00295160
129Abnormality of the lower motor neuron (HP:0002366)1.99250966
130Vertigo (HP:0002321)1.96796761
131Abnormal respiratory motile cilium physiology (HP:0012261)1.96597451
132Tongue fasciculations (HP:0001308)1.96140306
133Ectropion (HP:0000656)1.95399566
134Abnormality of the pleura (HP:0002103)1.93478321
135Gangrene (HP:0100758)1.93407087
136Osteomyelitis (HP:0002754)1.92582739
137Abnormality of the metopic suture (HP:0005556)1.91426779
138Cone-rod dystrophy (HP:0000548)1.90427980
139Hematochezia (HP:0002573)1.89611719
140Abnormality of T cells (HP:0002843)1.89184167
141Hypertriglyceridemia (HP:0002155)1.89126537
142Thin bony cortex (HP:0002753)1.87896751
143Abnormality of the peritoneum (HP:0002585)1.87737166
144Spondylolisthesis (HP:0003302)1.86822780
145Slow saccadic eye movements (HP:0000514)1.86820743
146Increased serum ferritin (HP:0003281)1.86398587
147Pulmonary artery stenosis (HP:0004415)1.85520559
148Panhypogammaglobulinemia (HP:0003139)1.84789993
149Abnormal platelet volume (HP:0011876)1.83445648
150Rhinitis (HP:0012384)1.82675263
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81961849
152Abnormality of polysaccharide metabolism (HP:0011012)1.81961849
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81961849
154Death in childhood (HP:0003819)1.80571575
155Abnormality of the endocardium (HP:0004306)1.80483723
156Narrow palate (HP:0000189)1.79998128
157Basal ganglia calcification (HP:0002135)1.79420300
158Segmental peripheral demyelination/remyelination (HP:0003481)1.79045545
159Increased CSF protein (HP:0002922)1.78215029
160Asymmetric septal hypertrophy (HP:0001670)1.77648982
161Abnormality of binocular vision (HP:0011514)1.77387880
162Arterial tortuosity (HP:0005116)1.76520751
163Protrusio acetabuli (HP:0003179)1.75841605
164Clumsiness (HP:0002312)1.75649774
165Abnormal respiratory motile cilium morphology (HP:0005938)1.75035089
166Abnormal respiratory epithelium morphology (HP:0012253)1.75035089
167Hypoplasia of the iris (HP:0007676)1.71937670
168Abnormality of the vocal cords (HP:0008777)1.71731939
169Nephritis (HP:0000123)1.70516320
170Mediastinal lymphadenopathy (HP:0100721)1.69821135
171Recurrent sinusitis (HP:0011108)1.67545205
172Viral hepatitis (HP:0006562)1.65912553
173Bicuspid aortic valve (HP:0001647)1.64415799
174Colitis (HP:0002583)1.63735081
175Bronchitis (HP:0012387)1.63149336
176Hypoventilation (HP:0002791)1.62728832
177Thin ribs (HP:0000883)1.61891046
178Primary amenorrhea (HP:0000786)1.61464159
179Recurrent otitis media (HP:0000403)1.60899362
180Polycystic ovaries (HP:0000147)1.60478059
181Nausea (HP:0002018)1.60121412
182Arachnodactyly (HP:0001166)1.58292215
183Prominent nose (HP:0000448)1.57878675
184Overriding aorta (HP:0002623)1.57592185
185Missing ribs (HP:0000921)1.56474946
186Increased variability in muscle fiber diameter (HP:0003557)1.56085799
187Increased connective tissue (HP:0009025)1.55207296
188Fibular hypoplasia (HP:0003038)1.54412037
189Autoimmune hemolytic anemia (HP:0001890)1.54176153
190Abnormality of subcutaneous fat tissue (HP:0001001)1.53144472
191Mitral valve prolapse (HP:0001634)1.53121008
192Flat cornea (HP:0007720)1.53029412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.86360104
2RIPK44.50902332
3CDK124.01710476
4ICK3.36360036
5BLK3.29819296
6TYRO33.29752808
7CAMK1D2.73091593
8EPHB12.70877623
9CAMK1G2.54125404
10TRIB32.46530994
11MAP2K32.41689070
12PRKD32.34688090
13TGFBR22.30170975
14FES2.24704414
15PDK42.15136060
16PDK32.15136060
17IRAK42.13011994
18PRPF4B2.12572045
19BRD41.99568027
20RIPK11.91114863
21CDK91.88236213
22PTK61.80047086
23DMPK1.77629925
24TTN1.74203587
25EEF2K1.57902702
26SYK1.53626482
27GRK61.51936443
28MAP3K111.51748968
29MAP3K131.48339628
30PDK21.48263025
31MAP4K11.46719905
32MAP3K31.46593962
33FGR1.45744166
34MOS1.43522473
35WNK11.38663975
36JAK21.38403425
37TAOK11.36178138
38MAP3K101.36048951
39MAP3K71.35918896
40PKN21.35351935
41PTK2B1.33680307
42MARK21.33144483
43TESK11.30825777
44ZAP701.29293738
45MAPK151.27678845
46MAP3K141.25564938
47MAP2K21.22838355
48BMX1.18938093
49LYN1.17147687
50MYLK1.15529256
51ERN11.14668590
52MTOR1.14137121
53PAK41.10870422
54TEC1.08547534
55DAPK21.07664423
56NEK21.07096710
57MAP3K11.06602798
58PAK21.05421414
59STK31.05296965
60MAP3K61.05221952
61CLK11.04659901
62SIK21.04464465
63KSR21.02158160
64WNK41.01988633
65LMTK21.01884423
66HCK1.00272959
67CDK70.99501107
68IRAK20.99475837
69MAPK70.98795013
70WNK30.97872810
71TXK0.97691678
72PDGFRA0.95819181
73TNK20.95062978
74ITK0.94030301
75KIT0.93227084
76JAK10.92076959
77CAMKK10.88223897
78TYK20.86387190
79CAMKK20.86124173
80MAP2K40.85737755
81GRK50.80751370
82CDK40.80695752
83TAOK30.79127339
84YES10.78848179
85CHUK0.78473501
86PIK3CG0.77951607
87CSK0.77426906
88NLK0.77152253
89IRAK10.76390807
90RPS6KC10.70825986
91RPS6KL10.70825986
92IKBKB0.70125545
93LATS10.69605894
94STK240.68605514
95DYRK1B0.68556331
96BTK0.68082297
97PINK10.67358244
98RPS6KA60.63998892
99MATK0.63566243
100FGFR40.62782046
101LRRK20.62682423
102RET0.62182730
103PDK10.61902852
104PRKD20.61058174
105FGFR30.60431882
106JAK30.59488043
107FYN0.59395900
108PDGFRB0.58521357
109CDC42BPA0.57664712
110CSF1R0.57453624
111PTK20.57272114
112TAOK20.57125322
113MAP3K40.57091265
114STK40.54682264
115IKBKE0.54270781
116PDPK10.53160091
117BMPR20.52390108
118MARK30.51788431
119HIPK20.51572682
120MAP3K20.50857667
121SGK4940.49956413
122SGK2230.49956413
123GRK10.49215179
124MAP3K50.49108118
125PRKCQ0.48760000
126EPHA30.48381520
127CAMK40.48082155
128PRKCH0.47374464
129RPS6KA20.45656947
130EGFR0.45647192
131STK100.45472058
132SGK30.43557435
133PHKG20.43527891
134PHKG10.43527891
135STK110.42000687
136TRPM70.41286752
137TBK10.41073615
138TGFBR10.39517025
139SIK10.38060479
140CSNK1A1L0.37635454
141GRK70.35224036
142STK380.34861599
143MAP3K90.34204982
144LCK0.32763862
145SIK30.31741337
146PRKD10.31611937
147PRKAA20.30976499
148MAPK120.29332163
149SGK20.28931458
150INSR0.28802064
151KDR0.27677644
152CAMK10.25698478
153MAPK10.25603518

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.09778208
2Tuberculosis_Homo sapiens_hsa051521.98805752
3Viral myocarditis_Homo sapiens_hsa054161.97460472
4Toxoplasmosis_Homo sapiens_hsa051451.83635098
5Fatty acid biosynthesis_Homo sapiens_hsa000611.80796684
6Graft-versus-host disease_Homo sapiens_hsa053321.79373066
7Malaria_Homo sapiens_hsa051441.79178805
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.76699706
9Allograft rejection_Homo sapiens_hsa053301.73811892
10B cell receptor signaling pathway_Homo sapiens_hsa046621.71664645
11Lysine degradation_Homo sapiens_hsa003101.71452872
12Osteoclast differentiation_Homo sapiens_hsa043801.70743413
13Antigen processing and presentation_Homo sapiens_hsa046121.68279829
14Small cell lung cancer_Homo sapiens_hsa052221.64580407
15Other glycan degradation_Homo sapiens_hsa005111.63568347
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58530667
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58417910
18Autoimmune thyroid disease_Homo sapiens_hsa053201.57351170
19T cell receptor signaling pathway_Homo sapiens_hsa046601.54889799
20Notch signaling pathway_Homo sapiens_hsa043301.51706792
21Amoebiasis_Homo sapiens_hsa051461.51440246
22ECM-receptor interaction_Homo sapiens_hsa045121.46150893
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.40755084
24Focal adhesion_Homo sapiens_hsa045101.32672488
25Phagosome_Homo sapiens_hsa041451.29761987
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28747770
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26404497
28VEGF signaling pathway_Homo sapiens_hsa043701.24070440
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21862711
30Acute myeloid leukemia_Homo sapiens_hsa052211.21689203
31Leishmaniasis_Homo sapiens_hsa051401.20717737
32Influenza A_Homo sapiens_hsa051641.20609785
33Estrogen signaling pathway_Homo sapiens_hsa049151.20326681
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19946379
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18737480
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17433685
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16641463
38Type I diabetes mellitus_Homo sapiens_hsa049401.16525639
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16012897
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15216108
41Primary immunodeficiency_Homo sapiens_hsa053401.14917594
42Chronic myeloid leukemia_Homo sapiens_hsa052201.14158121
43Inositol phosphate metabolism_Homo sapiens_hsa005621.14009205
44Measles_Homo sapiens_hsa051621.10950537
45Lysosome_Homo sapiens_hsa041421.10503319
46Legionellosis_Homo sapiens_hsa051341.09422552
47cAMP signaling pathway_Homo sapiens_hsa040241.08932107
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07680304
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07655281
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.06797519
51Ovarian steroidogenesis_Homo sapiens_hsa049131.05383581
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05096351
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04957729
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.02754890
55Dilated cardiomyopathy_Homo sapiens_hsa054141.02227937
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01619352
57Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01452282
58Axon guidance_Homo sapiens_hsa043601.01067930
59Renin secretion_Homo sapiens_hsa049241.00776169
60TGF-beta signaling pathway_Homo sapiens_hsa043500.99949436
61Insulin resistance_Homo sapiens_hsa049310.99619399
62Pertussis_Homo sapiens_hsa051330.99226365
63Basal transcription factors_Homo sapiens_hsa030220.98339785
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98118311
65HTLV-I infection_Homo sapiens_hsa051660.97776834
66Adherens junction_Homo sapiens_hsa045200.97357152
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.95691214
68Herpes simplex infection_Homo sapiens_hsa051680.94869445
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94716799
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91982086
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91139382
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.90883685
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89812291
74Rheumatoid arthritis_Homo sapiens_hsa053230.89568147
75Renal cell carcinoma_Homo sapiens_hsa052110.88907244
76Prolactin signaling pathway_Homo sapiens_hsa049170.88818290
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88731474
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.88523460
79HIF-1 signaling pathway_Homo sapiens_hsa040660.88270762
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87718578
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.87045114
82Hedgehog signaling pathway_Homo sapiens_hsa043400.86950780
83Platelet activation_Homo sapiens_hsa046110.86703935
84Choline metabolism in cancer_Homo sapiens_hsa052310.85812890
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.85660649
86African trypanosomiasis_Homo sapiens_hsa051430.85240189
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83961136
88Asthma_Homo sapiens_hsa053100.83845635
89Hematopoietic cell lineage_Homo sapiens_hsa046400.81806339
90Staphylococcus aureus infection_Homo sapiens_hsa051500.79926402
91Chemokine signaling pathway_Homo sapiens_hsa040620.79720761
92Colorectal cancer_Homo sapiens_hsa052100.79205879
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77959496
94Pancreatic cancer_Homo sapiens_hsa052120.77762843
95Rap1 signaling pathway_Homo sapiens_hsa040150.76222432
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.75764761
97PPAR signaling pathway_Homo sapiens_hsa033200.75623154
98Hepatitis C_Homo sapiens_hsa051600.74817542
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.74188510
100Hepatitis B_Homo sapiens_hsa051610.73195125
101TNF signaling pathway_Homo sapiens_hsa046680.73079067
102Proteoglycans in cancer_Homo sapiens_hsa052050.72967723
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72899917
104FoxO signaling pathway_Homo sapiens_hsa040680.72771518
105Fatty acid metabolism_Homo sapiens_hsa012120.72640520
106GnRH signaling pathway_Homo sapiens_hsa049120.70960391
107Pathways in cancer_Homo sapiens_hsa052000.70896910
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69963598
109Oxytocin signaling pathway_Homo sapiens_hsa049210.67734173
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67257595
111AMPK signaling pathway_Homo sapiens_hsa041520.66931313
112Endometrial cancer_Homo sapiens_hsa052130.66589895
113Type II diabetes mellitus_Homo sapiens_hsa049300.66525454
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65459443
115Non-small cell lung cancer_Homo sapiens_hsa052230.64660894
116Prostate cancer_Homo sapiens_hsa052150.64630767
117mTOR signaling pathway_Homo sapiens_hsa041500.64401097
118MAPK signaling pathway_Homo sapiens_hsa040100.63923384
119Insulin signaling pathway_Homo sapiens_hsa049100.63912737
120Endocytosis_Homo sapiens_hsa041440.63749554
121Salmonella infection_Homo sapiens_hsa051320.63275521
122Glioma_Homo sapiens_hsa052140.61311646
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60250108
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60124149
125ABC transporters_Homo sapiens_hsa020100.59611046
126Vitamin digestion and absorption_Homo sapiens_hsa049770.59297508
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58953127
128Apoptosis_Homo sapiens_hsa042100.58594571
129Complement and coagulation cascades_Homo sapiens_hsa046100.55591741
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.54081841
131Long-term potentiation_Homo sapiens_hsa047200.48905638
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.48767366
133Regulation of autophagy_Homo sapiens_hsa041400.41851013
134Cholinergic synapse_Homo sapiens_hsa047250.40888693

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