CDH26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.51865708
2xenobiotic catabolic process (GO:0042178)7.14646522
3regulation of cilium movement (GO:0003352)7.03519093
4glucuronate metabolic process (GO:0019585)6.61949138
5uronic acid metabolic process (GO:0006063)6.61949138
6extracellular regulation of signal transduction (GO:1900115)6.32580858
7extracellular negative regulation of signal transduction (GO:1900116)6.32580858
8ventricular system development (GO:0021591)6.00805165
9left/right pattern formation (GO:0060972)6.00135813
10cellular glucuronidation (GO:0052695)5.93888681
11phenylpropanoid metabolic process (GO:0009698)5.88716188
12antibacterial humoral response (GO:0019731)5.67885963
13opioid receptor signaling pathway (GO:0038003)5.64656138
14intraciliary transport (GO:0042073)5.57217819
15left/right axis specification (GO:0070986)5.50021349
16diterpenoid biosynthetic process (GO:0016102)5.38354539
17antimicrobial humoral response (GO:0019730)5.29854871
18multicellular organismal water homeostasis (GO:0050891)5.21907160
19positive regulation of macrophage activation (GO:0043032)5.20930453
20L-ascorbic acid metabolic process (GO:0019852)5.15756098
21cilium organization (GO:0044782)5.15214461
22protein localization to cilium (GO:0061512)5.12922962
23negative regulation of complement activation (GO:0045916)5.04856700
24retinoic acid metabolic process (GO:0042573)4.97437556
25regulation of germinal center formation (GO:0002634)4.97048737
26cilium assembly (GO:0042384)4.96329252
27microtubule bundle formation (GO:0001578)4.65805193
28ovulation cycle (GO:0042698)4.61977387
29response to xenobiotic stimulus (GO:0009410)4.57041305
30renal absorption (GO:0070293)4.56561219
31negative regulation of cytosolic calcium ion concentration (GO:0051481)4.40878977
32valine metabolic process (GO:0006573)4.40331071
33vitamin transmembrane transport (GO:0035461)4.27848147
34negative regulation of protein activation cascade (GO:2000258)4.26712119
35positive regulation of digestive system process (GO:0060456)4.21718218
36sensory perception of smell (GO:0007608)4.20995822
37retinol metabolic process (GO:0042572)4.18494757
38regulation of microtubule-based movement (GO:0060632)4.17765778
39regulation of cholesterol biosynthetic process (GO:0045540)4.13285282
40water homeostasis (GO:0030104)4.10166073
41atrioventricular valve morphogenesis (GO:0003181)4.09791601
42cilium morphogenesis (GO:0060271)4.08695513
43negative regulation of immunoglobulin mediated immune response (GO:0002890)3.93619799
44negative regulation of B cell mediated immunity (GO:0002713)3.93619799
45tachykinin receptor signaling pathway (GO:0007217)3.93102873
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.89266307
47one-carbon compound transport (GO:0019755)3.88175401
48negative regulation of toll-like receptor signaling pathway (GO:0034122)3.86127734
49O-glycan processing (GO:0016266)3.85313198
50cellular component assembly involved in morphogenesis (GO:0010927)3.84840675
51positive regulation of osteoblast proliferation (GO:0033690)3.81745858
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.80054799
53regulation of interleukin-5 production (GO:0032674)3.78547113
54regulation of cardioblast proliferation (GO:0003264)3.78461586
55regulation of secondary heart field cardioblast proliferation (GO:0003266)3.78461586
56pyrimidine-containing compound transmembrane transport (GO:0072531)3.77827933
57outer ear morphogenesis (GO:0042473)3.77417798
58photoreceptor cell maintenance (GO:0045494)3.71795475
59negative regulation of humoral immune response (GO:0002921)3.67337411
60centriole assembly (GO:0098534)3.66250885
61terpenoid biosynthetic process (GO:0016114)3.59812098
62sperm motility (GO:0030317)3.58002435
63tolerance induction (GO:0002507)3.57746608
64regulation of lipoprotein metabolic process (GO:0050746)3.56713932
65cell projection assembly (GO:0030031)3.54044730
66long-chain fatty acid biosynthetic process (GO:0042759)3.51392708
67sperm capacitation (GO:0048240)3.51347603
68negative regulation of inclusion body assembly (GO:0090084)3.49002194
69response to nitrosative stress (GO:0051409)3.47252592
70sulfur amino acid catabolic process (GO:0000098)3.46788061
71antigen processing and presentation via MHC class Ib (GO:0002475)3.46227229
72positive regulation of steroid biosynthetic process (GO:0010893)3.44825927
73positive regulation of cholesterol transport (GO:0032376)3.39189102
74positive regulation of sterol transport (GO:0032373)3.39189102
75lateral ventricle development (GO:0021670)3.29823232
76negative regulation of fibroblast proliferation (GO:0048147)3.29031286
77phospholipid homeostasis (GO:0055091)3.25624789
78microtubule-based movement (GO:0007018)3.23186414
79adaptation of signaling pathway (GO:0023058)3.23029686
80bundle of His cell to Purkinje myocyte communication (GO:0086069)3.19182040
81interleukin-1-mediated signaling pathway (GO:0070498)3.17524698
82behavioral response to pain (GO:0048266)3.14845727
83phosphatidylethanolamine biosynthetic process (GO:0006646)3.13577153
84phenol-containing compound catabolic process (GO:0019336)3.13458883
85cytoplasmic microtubule organization (GO:0031122)3.07725490
86exogenous drug catabolic process (GO:0042738)3.06034761
87nucleoside diphosphate phosphorylation (GO:0006165)3.04308712
88retinal rod cell development (GO:0046548)3.04096845
89negative regulation of T cell differentiation in thymus (GO:0033085)3.00452865
90negative regulation of granulocyte differentiation (GO:0030853)2.99324338
91phosphatidylethanolamine metabolic process (GO:0046337)2.98518272
92negative regulation of lipase activity (GO:0060192)2.96529652
93negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.96121510
94atrial septum morphogenesis (GO:0060413)2.92079808
95cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.91997609
96retinal cone cell development (GO:0046549)2.91589787
97import into cell (GO:0098657)2.91450070
98negative regulation of fatty acid transport (GO:2000192)2.90496733
99positive regulation of tolerance induction (GO:0002645)2.89112118
100carnitine metabolic process (GO:0009437)2.87503885
101iron ion import (GO:0097286)2.84933756
102negative regulation of telomere maintenance (GO:0032205)2.84376653
103positive regulation of actin filament depolymerization (GO:0030836)2.83346046
104regulation of interleukin-13 production (GO:0032656)2.83260365
105negative regulation of adaptive immune response (GO:0002820)2.80822416
106primary alcohol metabolic process (GO:0034308)2.80618308
107regulation of sodium ion transmembrane transport (GO:1902305)2.78263086
108linoleic acid metabolic process (GO:0043651)2.77003815
109cell differentiation involved in metanephros development (GO:0072202)2.76801312
110metanephric mesenchyme development (GO:0072075)2.74273385
111skeletal muscle cell differentiation (GO:0035914)2.73718310
112regulation of skeletal muscle contraction (GO:0014819)2.73669009
113response to pheromone (GO:0019236)2.73457055
114regulation of steroid hormone biosynthetic process (GO:0090030)2.73433383
115calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.71572687
116positive regulation of hormone biosynthetic process (GO:0046886)2.70928626
117apoptotic cell clearance (GO:0043277)2.70882969
118negative regulation of cAMP-mediated signaling (GO:0043951)2.70620505
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70326744
120hydrogen peroxide biosynthetic process (GO:0050665)2.69519613
121reactive oxygen species biosynthetic process (GO:1903409)2.68434093
122lipoxygenase pathway (GO:0019372)2.68203250
123behavioral response to ethanol (GO:0048149)2.67815071
124vagina development (GO:0060068)2.67402334
125endosome to melanosome transport (GO:0035646)2.65645201
126endosome to pigment granule transport (GO:0043485)2.65645201
127piRNA metabolic process (GO:0034587)2.64079866
128transmission of nerve impulse (GO:0019226)2.63603833
129multicellular organism reproduction (GO:0032504)2.63215556
130nephron epithelium morphogenesis (GO:0072088)2.63046171
131nephron tubule morphogenesis (GO:0072078)2.63046171
132benzene-containing compound metabolic process (GO:0042537)2.62744783
133protein carboxylation (GO:0018214)2.60471342
134peptidyl-glutamic acid carboxylation (GO:0017187)2.60471342
135microtubule polymerization or depolymerization (GO:0031109)2.60238159
136pharyngeal system development (GO:0060037)2.58448939
137glutathione derivative metabolic process (GO:1901685)2.57945069
138glutathione derivative biosynthetic process (GO:1901687)2.57945069
139heart valve morphogenesis (GO:0003179)2.57564699
140regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.57271824
141polyol transport (GO:0015791)2.56580422
142regulation of chemokine secretion (GO:0090196)2.56513940
143face development (GO:0060324)2.56012858
144arginine catabolic process (GO:0006527)2.55040184
145drug catabolic process (GO:0042737)2.54938167
146carnitine transmembrane transport (GO:1902603)2.54695305
147neurotransmitter biosynthetic process (GO:0042136)2.54612108
148fatty acid oxidation (GO:0019395)2.53713470
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53030302
150centriole replication (GO:0007099)2.52552745
151regulation of cholesterol metabolic process (GO:0090181)2.52359286
152neural tube formation (GO:0001841)2.51923911
153high-density lipoprotein particle remodeling (GO:0034375)2.51758669
154phosphatidylcholine biosynthetic process (GO:0006656)2.50531927
155neurotransmitter metabolic process (GO:0042133)2.48274078
156endocardial cushion morphogenesis (GO:0003203)2.47441067
157lipid oxidation (GO:0034440)2.47370685
158regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.47264766
159nonmotile primary cilium assembly (GO:0035058)2.46886619
160regulation of phospholipase A2 activity (GO:0032429)2.46351505
161xenobiotic metabolic process (GO:0006805)2.46268830
162regulation of collateral sprouting (GO:0048670)2.43429471
163lung epithelium development (GO:0060428)2.41661402
164interkinetic nuclear migration (GO:0022027)2.41295056
165smoothened signaling pathway (GO:0007224)2.40589050
166amino-acid betaine transport (GO:0015838)2.40545971
167carnitine transport (GO:0015879)2.40545971
168microtubule depolymerization (GO:0007019)2.39618889
169regulation of interleukin-6 biosynthetic process (GO:0045408)2.38643122
170rRNA catabolic process (GO:0016075)2.37294110
171glomerular epithelial cell development (GO:0072310)2.36993710
172organic cation transport (GO:0015695)2.36518234
173retinal metabolic process (GO:0042574)2.36361249
174axonemal dynein complex assembly (GO:0070286)15.4389075
175cilium or flagellum-dependent cell motility (GO:0001539)14.5317870
176ethanol oxidation (GO:0006069)14.1435175
177cilium movement (GO:0003341)12.3398047
178primary alcohol catabolic process (GO:0034310)11.7672923
179epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.4698925
180regulation of female gonad development (GO:2000194)11.4284360
181epithelial cilium movement (GO:0003351)10.8004697
182ethanol metabolic process (GO:0006067)10.2625413
183motile cilium assembly (GO:0044458)10.0999263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.62692660
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.42906728
3VDR_22108803_ChIP-Seq_LS180_Human3.17716111
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76647715
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.59335788
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47284367
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47021079
8* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.32009059
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.27989896
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.27039958
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.22797336
12ZNF274_21170338_ChIP-Seq_K562_Hela2.17758086
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17087260
14NRF2_20460467_ChIP-Seq_MEFs_Mouse2.16237623
15NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.16237623
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14995290
17TP53_18474530_ChIP-ChIP_U2OS_Human2.14449851
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14390663
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05097928
20* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.89293073
21DROSHA_22980978_ChIP-Seq_HELA_Human1.87428245
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.83679471
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82452438
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80494472
25* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.80364327
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77065834
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77065834
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73680244
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.73457058
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.72842312
31AHR_22903824_ChIP-Seq_MCF-7_Human1.72238064
32TP53_16413492_ChIP-PET_HCT116_Human1.71138611
33IGF1R_20145208_ChIP-Seq_DFB_Human1.67083664
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.66619366
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65724668
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63843856
37ER_23166858_ChIP-Seq_MCF-7_Human1.63832084
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63621334
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57374327
40SMAD4_21799915_ChIP-Seq_A2780_Human1.54593828
41FOXA1_25552417_ChIP-Seq_VCAP_Human1.51190056
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50885001
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49101999
44SOX2_20726797_ChIP-Seq_SW620_Human1.48999157
45* STAT3_23295773_ChIP-Seq_U87_Human1.47954338
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.46934995
47AR_20517297_ChIP-Seq_VCAP_Human1.46706633
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45114500
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44951184
50RXR_22108803_ChIP-Seq_LS180_Human1.43592488
51GBX2_23144817_ChIP-Seq_PC3_Human1.39978113
52SMRT_27268052_Chip-Seq_Bcells_Human1.39891110
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39272633
54SCL_19346495_ChIP-Seq_HPC-7_Human1.39136624
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.38798991
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.37538274
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35500031
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34888839
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34553596
60* TCF4_23295773_ChIP-Seq_U87_Human1.34464432
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.33964847
62TCF4_22108803_ChIP-Seq_LS180_Human1.31968226
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31767370
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31645366
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31178086
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30681365
67TAF15_26573619_Chip-Seq_HEK293_Human1.30535041
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30469825
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.29986659
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29986659
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29653882
72STAT1_20625510_ChIP-Seq_HELA_Human1.28915052
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27579740
74AR_25329375_ChIP-Seq_VCAP_Human1.26972892
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.26327788
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.25148442
77GATA3_26560356_Chip-Seq_TH2_Human1.25072215
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24710286
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24161412
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24161412
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24059910
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23903716
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22732751
84CBP_20019798_ChIP-Seq_JUKART_Human1.22732751
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21923452
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.21063409
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20638620
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19908195
89EWS_26573619_Chip-Seq_HEK293_Human1.19150952
90AR_21572438_ChIP-Seq_LNCaP_Human1.18987899
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18673650
92ETV1_20927104_ChIP-Seq_GIST48_Human1.17346730
93* RUNX1_27514584_Chip-Seq_MCF-7_Human1.17278440
94FUS_26573619_Chip-Seq_HEK293_Human1.16503426
95P300_19829295_ChIP-Seq_ESCs_Human1.16393431
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16381790
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.15448943
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15218010
99EZH2_22144423_ChIP-Seq_EOC_Human1.14738107
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14610089
101RUNX2_22187159_ChIP-Seq_PCA_Human1.14253111
102CJUN_26792858_Chip-Seq_BT549_Human1.14202882
103KLF5_25053715_ChIP-Seq_YYC3_Human1.14088399
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.13623805
105CDX2_22108803_ChIP-Seq_LS180_Human1.13547715
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.13135853
107RXR_22158963_ChIP-Seq_LIVER_Mouse1.12918621
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11655099
109ERG_20517297_ChIP-Seq_VCAP_Human1.11477340
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.10662704
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10586830
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09202019
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08319116
114GATA1_19941826_ChIP-Seq_K562_Human1.08163281
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07847837
116CEBPB_22108803_ChIP-Seq_LS180_Human1.07801579
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.07645461
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.07164478
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05953493
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05953493
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05953493
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05649922
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05532876
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05247240
125ISL1_27105846_Chip-Seq_CPCs_Mouse1.05122989
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05039819
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.04910462
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04642078
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03386392
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02935960
131GATA1_26923725_Chip-Seq_HPCs_Mouse1.02880485
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02420379
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01231121
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.01213163
135RUNX_20019798_ChIP-Seq_JUKART_Human1.00184167
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00128803
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.99933213
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99682077
139TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98988130
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98918009
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98291015
142* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98211897
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98208178
144SOX2_19829295_ChIP-Seq_ESCs_Human0.97953165
145NANOG_19829295_ChIP-Seq_ESCs_Human0.97953165
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97868310
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97637134
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.97437921
149* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97227599
150ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97092146
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97068752
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95673545
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95489817
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95489817
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94875300
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.94503863
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94174024
158GATA4_25053715_ChIP-Seq_YYC3_Human0.92416745
159FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91786564
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91707673
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91557596
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91133192
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91073504
164CLOCK_20551151_ChIP-Seq_293T_Human0.90301492
165NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90141496
166* TP63_23658742_ChIP-Seq_EP156T_Human0.89898188
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.88931202
168BCAT_22108803_ChIP-Seq_LS180_Human0.88405897
169FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87886271
170CDX2_20551321_ChIP-Seq_CACO-2_Human0.87712509
171PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86168504
172MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85431835
173CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85346584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.48770393
2MP0001984_abnormal_olfaction4.82978363
3MP0010030_abnormal_orbit_morphology4.81170218
4MP0005409_darkened_coat_color4.30645648
5MP0005499_abnormal_olfactory_system4.22170155
6MP0005394_taste/olfaction_phenotype4.22170155
7MP0008789_abnormal_olfactory_epithelium4.17625090
8MP0004019_abnormal_vitamin_homeostasis3.91382667
9MP0001346_abnormal_lacrimal_gland3.32971678
10MP0009379_abnormal_foot_pigmentation2.71526012
11MP0004264_abnormal_extraembryonic_tissu2.67034091
12MP0002277_abnormal_respiratory_mucosa2.57353057
13MP0003941_abnormal_skin_development2.33715106
14MP0004133_heterotaxia2.32987711
15MP0005646_abnormal_pituitary_gland2.31713289
16MP0000465_gastrointestinal_hemorrhage2.27706814
17MP0003828_pulmonary_edema2.12419713
18MP0005377_hearing/vestibular/ear_phenot2.08511816
19MP0003878_abnormal_ear_physiology2.08511816
20MP0009278_abnormal_bone_marrow2.01297777
21MP0005310_abnormal_salivary_gland2.00381306
22MP0002254_reproductive_system_inflammat1.99744916
23MP0003195_calcinosis1.96284677
24MP0001765_abnormal_ion_homeostasis1.96264299
25MP0003279_aneurysm1.92165637
26MP0003656_abnormal_erythrocyte_physiolo1.88341141
27MP0003172_abnormal_lysosome_physiology1.84788063
28MP0002653_abnormal_ependyma_morphology1.74326355
29MP0003186_abnormal_redox_activity1.72644033
30MP0002168_other_aberrant_phenotype1.70705375
31MP0002132_abnormal_respiratory_system1.69433953
32MP0001188_hyperpigmentation1.67920383
33MP0002735_abnormal_chemical_nociception1.65633026
34MP0005551_abnormal_eye_electrophysiolog1.62996405
35MP0008872_abnormal_physiological_respon1.58067461
36MP0001485_abnormal_pinna_reflex1.54654572
37MP0002233_abnormal_nose_morphology1.53402966
38MP0005636_abnormal_mineral_homeostasis1.52495444
39MP0004043_abnormal_pH_regulation1.50445301
40MP0005395_other_phenotype1.49199056
41MP0003718_maternal_effect1.47111091
42MP0000762_abnormal_tongue_morphology1.46376307
43MP0009780_abnormal_chondrocyte_physiolo1.45929758
44MP0005253_abnormal_eye_physiology1.44009662
45MP0001968_abnormal_touch/_nociception1.41396376
46MP0002249_abnormal_larynx_morphology1.41051052
47MP0002822_catalepsy1.40710015
48MP0005410_abnormal_fertilization1.40505822
49MP0002009_preneoplasia1.38303649
50MP0003303_peritoneal_inflammation1.35216882
51MP0008877_abnormal_DNA_methylation1.32498636
52MP0001929_abnormal_gametogenesis1.30965348
53MP0006292_abnormal_olfactory_placode1.29210847
54MP0003698_abnormal_male_reproductive1.28553346
55MP0005464_abnormal_platelet_physiology1.27123789
56MP0001835_abnormal_antigen_presentation1.25350605
57MP0002160_abnormal_reproductive_system1.21819252
58MP0002909_abnormal_adrenal_gland1.19052674
59MP0000049_abnormal_middle_ear1.15781743
60MP0004742_abnormal_vestibular_system1.14866004
61MP0010386_abnormal_urinary_bladder1.13679594
62MP0000371_diluted_coat_color1.13451636
63MP0002166_altered_tumor_susceptibility1.13118815
64MP0010155_abnormal_intestine_physiology1.11005519
65MP0002638_abnormal_pupillary_reflex1.07413356
66MP0005167_abnormal_blood-brain_barrier1.07311444
67MP0001545_abnormal_hematopoietic_system1.06154131
68MP0005397_hematopoietic_system_phenotyp1.06154131
69MP0005248_abnormal_Harderian_gland1.04505058
70MP0000372_irregular_coat_pigmentation1.04403275
71MP0009643_abnormal_urine_homeostasis1.03416856
72MP0001915_intracranial_hemorrhage1.03210931
73MP0010329_abnormal_lipoprotein_level1.01620353
74MP0005083_abnormal_biliary_tract0.99744747
75MP0002060_abnormal_skin_morphology0.99637271
76MP0002736_abnormal_nociception_after0.99460966
77MP0005508_abnormal_skeleton_morphology0.99149970
78MP0004782_abnormal_surfactant_physiolog0.96262683
79MP0003566_abnormal_cell_adhesion0.94686839
80MP0000613_abnormal_salivary_gland0.93823905
81MP0000383_abnormal_hair_follicle0.93414193
82MP0002896_abnormal_bone_mineralization0.93071430
83MP0003075_altered_response_to0.92445388
84MP0010368_abnormal_lymphatic_system0.91994515
85MP0005023_abnormal_wound_healing0.91465812
86MP0003136_yellow_coat_color0.90132349
87MP0005365_abnormal_bile_salt0.89775271
88MP0002075_abnormal_coat/hair_pigmentati0.88172817
89MP0001764_abnormal_homeostasis0.87644321
90MP0001790_abnormal_immune_system0.87138258
91MP0005387_immune_system_phenotype0.87138258
92MP0003806_abnormal_nucleotide_metabolis0.87070543
93MP0003633_abnormal_nervous_system0.86907080
94MP0000678_abnormal_parathyroid_gland0.86857445
95MP0002136_abnormal_kidney_physiology0.86154811
96MP0000566_synostosis0.85657785
97MP0009046_muscle_twitch0.85381711
98MP0002229_neurodegeneration0.84839041
99MP0001664_abnormal_digestion0.84113728
100MP0005085_abnormal_gallbladder_physiolo0.84089108
101MP0002133_abnormal_respiratory_system0.82693464
102MP0005388_respiratory_system_phenotype0.82693464
103MP0002148_abnormal_hypersensitivity_rea0.82101092
104MP0002796_impaired_skin_barrier0.81878236
105MP0000534_abnormal_ureter_morphology0.81534358
106MP0005389_reproductive_system_phenotype0.81341478
107MP0003646_muscle_fatigue0.80931556
108MP0005647_abnormal_sex_gland0.80288290
109MP0001186_pigmentation_phenotype0.79398685
110MP0001756_abnormal_urination0.79004131
111MP0005220_abnormal_exocrine_pancreas0.78983178
112MP0005164_abnormal_response_to0.77477766
113MP0001501_abnormal_sleep_pattern0.77158424
114MP0000427_abnormal_hair_cycle0.76002514
115MP0003866_abnormal_defecation0.75862970
116MP0003252_abnormal_bile_duct0.75804243
117MP0005165_increased_susceptibility_to0.75641115
118MP0000778_abnormal_nervous_system0.74589904
119MP0003959_abnormal_lean_body0.74089225
120MP0004147_increased_porphyrin_level0.73953593
121MP0005671_abnormal_response_to0.73641541
122MP0005025_abnormal_response_to0.73600710
123MP0000653_abnormal_sex_gland0.72584111
124MP0003938_abnormal_ear_development0.72354828
125MP0002098_abnormal_vibrissa_morphology0.72279499
126MP0001800_abnormal_humoral_immune0.71623317
127MP0003943_abnormal_hepatobiliary_system0.71324244
128MP0005376_homeostasis/metabolism_phenot0.71044427
129MP0001145_abnormal_male_reproductive0.70347301
130MP0000467_abnormal_esophagus_morphology0.70069183
131MP0000230_abnormal_systemic_arterial0.69517087
132MP0009765_abnormal_xenobiotic_induced0.67607713
133MP0003638_abnormal_response/metabolism_0.67186467
134MP0002733_abnormal_thermal_nociception0.66585875
135MP0001486_abnormal_startle_reflex0.66523382
136MP0002723_abnormal_immune_serum0.66202044
137MP0004885_abnormal_endolymph0.65901843
138MP0000647_abnormal_sebaceous_gland0.65741102
139MP0010678_abnormal_skin_adnexa0.65258433
140MP0009250_abnormal_appendicular_skeleto0.64908270
141MP0001270_distended_abdomen0.63551766
142MP0004484_altered_response_of0.63029444
143MP0003453_abnormal_keratinocyte_physiol0.61118301
144MP0001542_abnormal_bone_strength0.59488511
145MP0001970_abnormal_pain_threshold0.59277967
146MP0002272_abnormal_nervous_system0.58478146
147MP0001963_abnormal_hearing_physiology0.57482813
148MP0006054_spinal_hemorrhage0.56412436
149MP0002282_abnormal_trachea_morphology0.56255657
150MP0003300_gastrointestinal_ulcer0.54735173
151MP0003755_abnormal_palate_morphology0.54662465
152MP0002734_abnormal_mechanical_nocicepti0.54284223
153MP0003631_nervous_system_phenotype0.53719438
154MP0010771_integument_phenotype0.53323677
155MP0006072_abnormal_retinal_apoptosis0.52397102
156MP0001958_emphysema0.51499472
157MP0001340_abnormal_eyelid_morphology0.51001883
158MP0009745_abnormal_behavioral_response0.49986249
159MP0002116_abnormal_craniofacial_bone0.48509132
160MP0003690_abnormal_glial_cell0.48082440
161MP0003724_increased_susceptibility_to0.47675430
162MP0001216_abnormal_epidermal_layer0.47353957
163MP0001177_atelectasis0.46918710
164MP0002876_abnormal_thyroid_physiology0.45957181
165MP0000631_abnormal_neuroendocrine_gland0.45320453
166MP0009764_decreased_sensitivity_to0.44792827
167MP0005645_abnormal_hypothalamus_physiol0.44771132
168MP0001324_abnormal_eye_pigmentation0.44624370
169MP0000377_abnormal_hair_follicle0.44544735
170MP0002295_abnormal_pulmonary_circulatio0.43832295

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.90184201
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.90184201
3Abnormal respiratory motile cilium morphology (HP:0005938)9.74437245
4Abnormal respiratory epithelium morphology (HP:0012253)9.74437245
5Abnormal ciliary motility (HP:0012262)9.52291145
6Abnormal respiratory motile cilium physiology (HP:0012261)9.49769790
7Rhinitis (HP:0012384)8.53043314
8Distal lower limb muscle weakness (HP:0009053)7.47318531
9Chronic bronchitis (HP:0004469)7.02948386
10Bronchiectasis (HP:0002110)6.47992234
11Scanning speech (HP:0002168)5.83409533
12Nasal polyposis (HP:0100582)5.31446709
13Esophageal atresia (HP:0002032)4.48661056
14Recurrent sinusitis (HP:0011108)4.44352154
15Abnormality of the nasal mucosa (HP:0000433)4.29749043
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.11101981
17Bronchitis (HP:0012387)4.08866563
18Abnormality of the nasal septum (HP:0000419)3.94976286
19Pancreatic fibrosis (HP:0100732)3.90979108
20Hyperactive renin-angiotensin system (HP:0000841)3.88981443
21Lip pit (HP:0100267)3.88275227
22True hermaphroditism (HP:0010459)3.78793384
23Infertility (HP:0000789)3.68789227
24Abnormal hemoglobin (HP:0011902)3.58537876
25Chronic sinusitis (HP:0011109)3.52300393
26Upper motor neuron abnormality (HP:0002127)3.48725687
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.48376816
28Pancreatic cysts (HP:0001737)3.45997247
29Decreased subcutaneous fat (HP:0001002)3.45813065
30Increased circulating renin level (HP:0000848)3.43357398
31Nephronophthisis (HP:0000090)3.40007554
32Recurrent otitis media (HP:0000403)3.18721230
33Abnormality of midbrain morphology (HP:0002418)3.16272888
34Molar tooth sign on MRI (HP:0002419)3.16272888
35Renal cortical cysts (HP:0000803)3.10015873
36Stridor (HP:0010307)3.09967447
37Increased cerebral lipofuscin (HP:0011813)3.09591264
38Submucous cleft hard palate (HP:0000176)3.08442477
39Chronic otitis media (HP:0000389)3.07512770
40Occipital encephalocele (HP:0002085)3.05305797
41Gastrointestinal atresia (HP:0002589)3.05152163
42Abnormality of the renal medulla (HP:0100957)3.02766543
43Tubulointerstitial nephritis (HP:0001970)3.00809979
44Abnormal platelet function (HP:0011869)2.93026151
45Impaired platelet aggregation (HP:0003540)2.93026151
46Cystic liver disease (HP:0006706)2.92688987
47Chronic hepatic failure (HP:0100626)2.91401993
48Male infertility (HP:0003251)2.91134295
49Metabolic alkalosis (HP:0200114)2.81092636
50Axonal loss (HP:0003447)2.80604753
51Hyperaldosteronism (HP:0000859)2.79284186
52Right ventricular cardiomyopathy (HP:0011663)2.75778949
53Tetany (HP:0001281)2.73446367
54Hypokalemic alkalosis (HP:0001949)2.70028095
55Renal tubular acidosis (HP:0001947)2.67227200
56Median cleft lip (HP:0000161)2.66408582
57Diaphragmatic weakness (HP:0009113)2.61247357
58Urethral obstruction (HP:0000796)2.60571415
59Pustule (HP:0200039)2.59141989
60Large eyes (HP:0001090)2.58931734
61Ulnar bowing (HP:0003031)2.57435268
62Medial flaring of the eyebrow (HP:0010747)2.56901730
63Neoplasm of the adrenal cortex (HP:0100641)2.53926984
64Decreased central vision (HP:0007663)2.51068388
65Polydipsia (HP:0001959)2.50691229
66Abnormal drinking behavior (HP:0030082)2.50691229
67Decreased circulating renin level (HP:0003351)2.48001711
68Xerostomia (HP:0000217)2.42041448
69Stomach cancer (HP:0012126)2.39873765
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39343899
71Congenital hepatic fibrosis (HP:0002612)2.38367619
72Hepatoblastoma (HP:0002884)2.38200626
73Hypoplasia of the fovea (HP:0007750)2.37947960
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.37947960
75Syncope (HP:0001279)2.37083861
76Hypercalciuria (HP:0002150)2.32753812
77Poor coordination (HP:0002370)2.32701042
78Abnormal biliary tract morphology (HP:0012440)2.31619565
79Postaxial foot polydactyly (HP:0001830)2.31020701
80Long foot (HP:0001833)2.29763703
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27155745
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.27155745
83Dysphonia (HP:0001618)2.25652914
84Abnormality of chloride homeostasis (HP:0011422)2.24599150
85Hyperkalemia (HP:0002153)2.24198471
86Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.23209929
87Congenital primary aphakia (HP:0007707)2.22428068
88Bronchomalacia (HP:0002780)2.22193909
89Atelectasis (HP:0100750)2.19546541
90Hydroureter (HP:0000072)2.18804119
91Partial agenesis of the corpus callosum (HP:0001338)2.18646979
92Pulmonary artery stenosis (HP:0004415)2.18105649
93Premature rupture of membranes (HP:0001788)2.18090509
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18017354
95Progressive visual loss (HP:0000529)2.17836462
96Male pseudohermaphroditism (HP:0000037)2.16913118
97Pigmentary retinal degeneration (HP:0001146)2.14687480
98Abnormality of DNA repair (HP:0003254)2.14238289
99Gait imbalance (HP:0002141)2.11853764
100Segmental peripheral demyelination/remyelination (HP:0003481)2.10141384
101Spinal rigidity (HP:0003306)2.09797087
102Abnormality of renin-angiotensin system (HP:0000847)2.09613918
103Humeroradial synostosis (HP:0003041)2.09503247
104Synostosis involving the elbow (HP:0003938)2.09503247
105Abnormality of the preputium (HP:0100587)2.08774587
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.08148922
107Abnormality of macular pigmentation (HP:0008002)2.07300392
108Bifid scrotum (HP:0000048)2.07093243
109Recurrent bronchitis (HP:0002837)2.06685310
110Abnormality of the middle phalanges of the toes (HP:0010183)2.06092756
111Arterial tortuosity (HP:0005116)2.05710541
112High pitched voice (HP:0001620)2.05131608
113Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.03940450
114Aplasia involving bones of the upper limbs (HP:0009823)2.03630027
115Aplasia of the phalanges of the hand (HP:0009802)2.03630027
116Aplasia involving bones of the extremities (HP:0009825)2.03630027
117Tubular atrophy (HP:0000092)2.02799790
118Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02674889
119Furrowed tongue (HP:0000221)2.01695384
120Down-sloping shoulders (HP:0200021)2.00489485
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6052303
122Clumsiness (HP:0002312)1.96663175
123Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96377574
124Morphological abnormality of the middle ear (HP:0008609)1.95849449
125Short hallux (HP:0010109)1.95794096
126Asplenia (HP:0001746)1.93348550
127Vascular tortuosity (HP:0004948)1.92892919
128Nephrogenic diabetes insipidus (HP:0009806)1.92048294
129Abnormality of magnesium homeostasis (HP:0004921)1.91968162
130Fragile skin (HP:0001030)1.90904239
131Cone-rod dystrophy (HP:0000548)1.90480146
132Abnormality of the renal cortex (HP:0011035)1.89203319
133Abnormality of subcutaneous fat tissue (HP:0001001)1.89075023
134Preauricular pit (HP:0004467)1.85807944
135Periauricular skin pits (HP:0100277)1.85807944
136Spastic paraplegia (HP:0001258)1.84515609
137Diplopia (HP:0000651)1.84007169
138Abnormality of binocular vision (HP:0011514)1.84007169
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.83937825
140Anencephaly (HP:0002323)1.83086043
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.81777475
142Aplasia/Hypoplasia of the macula (HP:0008059)1.81633898
143Macular degeneration (HP:0000608)1.81135276
144Abnormality of the fovea (HP:0000493)1.80649873
145Abnormal pancreas size (HP:0012094)1.80573441
146Genital tract atresia (HP:0001827)1.79519999
147Limb hypertonia (HP:0002509)1.78352248
148Bell-shaped thorax (HP:0001591)1.75972985
149Abnormality of the corticospinal tract (HP:0002492)1.75380313
150Short chin (HP:0000331)1.75239306
151Septo-optic dysplasia (HP:0100842)1.73240354
152Follicular hyperkeratosis (HP:0007502)1.72925811
153Abnormality of fatty-acid metabolism (HP:0004359)1.72282582
154Vaginal atresia (HP:0000148)1.72033995
155Conjugated hyperbilirubinemia (HP:0002908)1.71944047
156Oculomotor apraxia (HP:0000657)1.71767590
157Renal salt wasting (HP:0000127)1.69154702
158Tubulointerstitial abnormality (HP:0001969)1.68645578
159Nephropathy (HP:0000112)1.66624762
160Abnormal rod and cone electroretinograms (HP:0008323)1.65417501
161Postaxial hand polydactyly (HP:0001162)1.61345201
162Abolished electroretinogram (ERG) (HP:0000550)1.59080765
163Azoospermia (HP:0000027)1.53306676
164Congenital stationary night blindness (HP:0007642)1.50558816
165Abnormal biliary tract physiology (HP:0012439)1.47169287
166Bile duct proliferation (HP:0001408)1.47169287
167Sclerocornea (HP:0000647)1.44332250
168Stage 5 chronic kidney disease (HP:0003774)1.41200379
169Retinitis pigmentosa (HP:0000510)1.40329390
170Amelogenesis imperfecta (HP:0000705)1.34013252
171Gaze-evoked nystagmus (HP:0000640)1.32811827
172Elevated erythrocyte sedimentation rate (HP:0003565)1.32250816
173Abnormal spermatogenesis (HP:0008669)1.32064896
174Absent speech (HP:0001344)1.31237586
175Constricted visual fields (HP:0001133)1.28287567
176Widely spaced teeth (HP:0000687)1.25607863
177Progressive inability to walk (HP:0002505)1.25237091
178Attenuation of retinal blood vessels (HP:0007843)1.24079829
179Hypoplastic labia majora (HP:0000059)1.23653644
180Recurrent pneumonia (HP:0006532)1.22186250
181Abnormality of permanent molar morphology (HP:0011071)1.20101587
182Abnormality of the dental root (HP:0006486)1.20101587
183Taurodontia (HP:0000679)1.20101587
184Preaxial hand polydactyly (HP:0001177)1.18758159
185Dyschromatopsia (HP:0007641)1.15165194
186Portal hypertension (HP:0001409)1.14862928
187Hyperventilation (HP:0002883)1.14241709
188Insulin-resistant diabetes mellitus (HP:0000831)1.14085236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK38.60109555
2SIK15.69673440
3SIK25.47181551
4MST44.37435442
5ADRBK24.04603045
6TYRO33.15957591
7MAP4K22.43727863
8PBK2.37627654
9MARK32.18879391
10SGK31.97144916
11NEK61.83054184
12PNCK1.80274359
13PTK2B1.74471463
14BRSK21.71970374
15TAOK11.67249429
16RPS6KB21.61914272
17ERBB31.60810775
18TAOK31.60286992
19PAK31.59839880
20HIPK21.53464475
21GRK11.53016326
22MAPK151.51487951
23ACVR1B1.50495433
24RIPK11.43512252
25MARK21.36396364
26MAP2K31.34136683
27MAP3K31.32641506
28TAOK21.32618667
29PDK31.24198896
30PDK41.24198896
31IRAK11.23371187
32MAP3K41.22184230
33CAMK1D1.21069372
34TRPM71.17135680
35CDK61.16703515
36KIT1.14389561
37RIPK41.13002698
38CAMK1G1.12644158
39GRK61.11801765
40NUAK11.11548081
41EPHB21.10986677
42CSK1.10898694
43ZAK1.06946657
44MAPK131.06502097
45BMPR1B1.05835461
46MATK1.05663054
47FES1.04503478
48SGK21.03787169
49PRKG21.01715211
50MAP2K21.00497021
51TEC1.00085848
52MAPKAPK31.00080035
53EPHA30.99801465
54STK100.99108850
55MAP3K70.98378903
56WNK40.98120580
57SGK2230.93916419
58SGK4940.93916419
59AKT30.90241783
60ERN10.90040610
61STK240.89524091
62MKNK20.89103573
63CAMKK20.87863663
64PRKAA20.85192836
65LATS10.81300256
66ADRBK10.80189875
67CSNK1A1L0.74370117
68BCKDK0.73649059
69PDK20.68065382
70STK38L0.67268736
71FER0.66159555
72TNIK0.65967999
73TBK10.64411822
74MAP3K110.62308951
75BTK0.61577106
76PRKD20.59517719
77WNK30.58938519
78MAP2K10.58099756
79ERBB20.55559538
80TESK10.53905523
81MAPKAPK50.52766782
82TNK20.51251943
83CAMK2D0.50787837
84BLK0.50786821
85LYN0.50725939
86PRKCQ0.50640059
87NME10.48972772
88FRK0.48249660
89TLK10.48154110
90WNK10.48018552
91PRKCE0.46946265
92INSRR0.46700362
93CAMKK10.46464908
94TGFBR10.45986668
95LRRK20.44402908
96VRK10.42750425
97MAP3K10.40553823
98HCK0.40148855
99PRKCI0.39661396
100CAMK2A0.38704810
101EIF2AK30.38607189
102IRAK30.38385930
103IGF1R0.38085887
104TYK20.37405130
105STK110.36724252
106IKBKB0.36583026
107CAMK2B0.36552287
108TTN0.36366169
109EIF2AK10.35922072
110BMPR20.35636360
111STK30.35126402
112CDC42BPA0.35110987
113PRKD10.34590570
114SYK0.34152724
115ABL10.33834798
116AKT20.32576565
117DDR20.31915948
118NLK0.31740154
119PRKCG0.31671380
120NTRK30.31643072
121TIE10.31476387
122STK380.31471859
123PINK10.31324202
124NEK90.31136080
125ALK0.30380472
126TSSK60.30369064
127MAP2K60.30330702
128OXSR10.29065001
129PRKCD0.28973753
130LMTK20.28039971
131BCR0.26677291
132MUSK0.26474302
133GRK50.26365442
134MST1R0.25619557
135JAK10.25397050
136PRKACA0.24790667
137CDK190.24360371
138BMX0.24319461
139EEF2K0.23806076
140MAP2K70.23662186
141CLK10.23610078
142LIMK10.21394216
143CAMK2G0.21290480
144MINK10.18171458
145PAK60.18109038
146SGK10.17973329
147MAPK70.17418920
148MAP3K20.17268592
149STK390.17071300
150LATS20.16961646
151MKNK10.16800747
152TTK0.16363413
153MAP2K40.15407298
154MAP3K50.14935589
155CASK0.14604880
156EPHA20.14466012
157ROCK20.13790661
158ROCK10.13240992
159RPS6KA20.12932387
160MAP3K120.11787392
161CSNK1G20.11323275
162PRKCA0.10775469
163SRC0.09255993
164MARK10.08908506
165DAPK20.08574714
166PRKG10.08210188

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.46440265
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.30650833
3Chemical carcinogenesis_Homo sapiens_hsa052044.63202983
4Sulfur metabolism_Homo sapiens_hsa009203.97818186
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.87048816
6Tyrosine metabolism_Homo sapiens_hsa003503.80153994
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08929009
8Retinol metabolism_Homo sapiens_hsa008303.07772541
9Linoleic acid metabolism_Homo sapiens_hsa005913.01858501
10Phenylalanine metabolism_Homo sapiens_hsa003602.80682376
11Histidine metabolism_Homo sapiens_hsa003402.52500098
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.46131329
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36891005
14Fatty acid degradation_Homo sapiens_hsa000712.28601868
15Sulfur relay system_Homo sapiens_hsa041222.16066496
16beta-Alanine metabolism_Homo sapiens_hsa004102.00508352
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.98962985
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92938554
19Glutathione metabolism_Homo sapiens_hsa004801.55638808
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45560190
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43611508
22Asthma_Homo sapiens_hsa053101.40671254
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38671793
24Nitrogen metabolism_Homo sapiens_hsa009101.37708436
25Nicotine addiction_Homo sapiens_hsa050331.27929878
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21683346
27Huntingtons disease_Homo sapiens_hsa050161.18909505
28Circadian rhythm_Homo sapiens_hsa047101.17264970
29Steroid biosynthesis_Homo sapiens_hsa001001.15638710
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10544636
31Taste transduction_Homo sapiens_hsa047421.10209631
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.08990669
33Starch and sucrose metabolism_Homo sapiens_hsa005001.06182900
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.05055020
35ABC transporters_Homo sapiens_hsa020101.04317591
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02666389
37Butanoate metabolism_Homo sapiens_hsa006501.01911941
38Ether lipid metabolism_Homo sapiens_hsa005651.01747263
39Olfactory transduction_Homo sapiens_hsa047401.01733688
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95191738
41Gastric acid secretion_Homo sapiens_hsa049710.93988571
42Regulation of autophagy_Homo sapiens_hsa041400.92913053
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.91907960
44Sphingolipid metabolism_Homo sapiens_hsa006000.81153639
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81117234
46Hematopoietic cell lineage_Homo sapiens_hsa046400.79550266
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78290019
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74917826
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71656687
50Calcium signaling pathway_Homo sapiens_hsa040200.66420859
51Collecting duct acid secretion_Homo sapiens_hsa049660.66326436
52Graft-versus-host disease_Homo sapiens_hsa053320.66049321
53Tight junction_Homo sapiens_hsa045300.65054876
54Platelet activation_Homo sapiens_hsa046110.64523221
55Choline metabolism in cancer_Homo sapiens_hsa052310.62650447
56Adherens junction_Homo sapiens_hsa045200.62036603
57Allograft rejection_Homo sapiens_hsa053300.61785228
58Vitamin digestion and absorption_Homo sapiens_hsa049770.60854568
59Antigen processing and presentation_Homo sapiens_hsa046120.60504676
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60306498
61Glycerolipid metabolism_Homo sapiens_hsa005610.59118476
62Type I diabetes mellitus_Homo sapiens_hsa049400.59035345
63Vibrio cholerae infection_Homo sapiens_hsa051100.58076370
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57474470
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56554975
66Arginine and proline metabolism_Homo sapiens_hsa003300.55499753
67Autoimmune thyroid disease_Homo sapiens_hsa053200.55451197
68Staphylococcus aureus infection_Homo sapiens_hsa051500.55283688
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54515102
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52941035
71TNF signaling pathway_Homo sapiens_hsa046680.52641331
72Cocaine addiction_Homo sapiens_hsa050300.52333838
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50069736
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50068307
75Dorso-ventral axis formation_Homo sapiens_hsa043200.49586154
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49584608
77Morphine addiction_Homo sapiens_hsa050320.49304616
78Cholinergic synapse_Homo sapiens_hsa047250.45758004
79Rheumatoid arthritis_Homo sapiens_hsa053230.45581305
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.45511458
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.45204047
82Legionellosis_Homo sapiens_hsa051340.44817179
83Renin secretion_Homo sapiens_hsa049240.43804010
84Estrogen signaling pathway_Homo sapiens_hsa049150.43771872
85Mineral absorption_Homo sapiens_hsa049780.43770630
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40547700
87Galactose metabolism_Homo sapiens_hsa000520.39457442
88TGF-beta signaling pathway_Homo sapiens_hsa043500.39084028
89Synaptic vesicle cycle_Homo sapiens_hsa047210.39041175
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38976817
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37370268
92Homologous recombination_Homo sapiens_hsa034400.36462446
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36370401
94Metabolic pathways_Homo sapiens_hsa011000.36297962
95Fatty acid metabolism_Homo sapiens_hsa012120.35095321
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.35025875
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34856515
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34625557
99Circadian entrainment_Homo sapiens_hsa047130.33714583
100Selenocompound metabolism_Homo sapiens_hsa004500.32861712
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32465415
102Dopaminergic synapse_Homo sapiens_hsa047280.32446188
103Peroxisome_Homo sapiens_hsa041460.32004288
104African trypanosomiasis_Homo sapiens_hsa051430.31273746
105Ovarian steroidogenesis_Homo sapiens_hsa049130.31178562
106Salmonella infection_Homo sapiens_hsa051320.30538927
107Fatty acid elongation_Homo sapiens_hsa000620.30436908
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.30169999
109Phagosome_Homo sapiens_hsa041450.29591380
110Insulin resistance_Homo sapiens_hsa049310.29458219
111Propanoate metabolism_Homo sapiens_hsa006400.29446543
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29426678
113Axon guidance_Homo sapiens_hsa043600.29115703
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28683934
115Caffeine metabolism_Homo sapiens_hsa002320.26351630
116Amoebiasis_Homo sapiens_hsa051460.26244508
117Arachidonic acid metabolism_Homo sapiens_hsa005900.26154136
118Insulin secretion_Homo sapiens_hsa049110.26032350
119Pertussis_Homo sapiens_hsa051330.25487909
120Renin-angiotensin system_Homo sapiens_hsa046140.25233000
121Protein export_Homo sapiens_hsa030600.24973607
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24769246
123Influenza A_Homo sapiens_hsa051640.24307917
124Tuberculosis_Homo sapiens_hsa051520.24104899
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.24024709
126Complement and coagulation cascades_Homo sapiens_hsa046100.24013141
127Leishmaniasis_Homo sapiens_hsa051400.23707144
128Pancreatic secretion_Homo sapiens_hsa049720.23705225
129cAMP signaling pathway_Homo sapiens_hsa040240.23649292
130Non-homologous end-joining_Homo sapiens_hsa034500.23335237
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23280576
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22806668
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22465858
134Amphetamine addiction_Homo sapiens_hsa050310.22332565
135Thyroid hormone synthesis_Homo sapiens_hsa049180.22097248
136Proteoglycans in cancer_Homo sapiens_hsa052050.21401303
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19325265
138Salivary secretion_Homo sapiens_hsa049700.19254000
139Serotonergic synapse_Homo sapiens_hsa047260.19096342
140Rap1 signaling pathway_Homo sapiens_hsa040150.18906345
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18481076
142Hippo signaling pathway_Homo sapiens_hsa043900.17305024
143Melanoma_Homo sapiens_hsa052180.16307780
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12212096
145GnRH signaling pathway_Homo sapiens_hsa049120.11302589
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11045526
147Tryptophan metabolism_Homo sapiens_hsa003800.10928570
148Lysine degradation_Homo sapiens_hsa003100.10766692
149Fatty acid biosynthesis_Homo sapiens_hsa000610.10558034
150Phototransduction_Homo sapiens_hsa047440.10195549
151ECM-receptor interaction_Homo sapiens_hsa045120.10172951
152GABAergic synapse_Homo sapiens_hsa047270.08989901

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »