CDH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte proliferation (GO:0043616)7.73878647
2hemidesmosome assembly (GO:0031581)6.94975971
3desmosome organization (GO:0002934)5.87898920
4* regulation of keratinocyte proliferation (GO:0010837)4.66633594
5intermediate filament organization (GO:0045109)4.64538451
6epidermis development (GO:0008544)4.63368946
7surfactant homeostasis (GO:0043129)4.61868323
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54530568
9paraxial mesoderm development (GO:0048339)4.53936167
10multicellular organismal water homeostasis (GO:0050891)4.52070511
11* keratinization (GO:0031424)4.39885598
12positive regulation of epidermis development (GO:0045684)4.26895178
13positive regulation of epidermal cell differentiation (GO:0045606)4.26686484
14hair cycle (GO:0042633)4.25054616
15molting cycle (GO:0042303)4.25054616
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.22509311
17regulation of posttranscriptional gene silencing (GO:0060147)4.16298322
18regulation of gene silencing by miRNA (GO:0060964)4.16298322
19regulation of gene silencing by RNA (GO:0060966)4.16298322
20chemical homeostasis within a tissue (GO:0048875)4.07587490
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.99410694
22positive regulation of hair follicle development (GO:0051798)3.98377624
23positive regulation of hair cycle (GO:0042635)3.98377624
24polarized epithelial cell differentiation (GO:0030859)3.92326184
25trophectodermal cell differentiation (GO:0001829)3.79912225
26regulation of hippo signaling (GO:0035330)3.79895192
27cell adhesion mediated by integrin (GO:0033627)3.70672753
28water homeostasis (GO:0030104)3.69656910
29epithelial cell differentiation involved in prostate gland development (GO:0060742)3.65206995
30establishment of apical/basal cell polarity (GO:0035089)3.63118062
31cell-substrate junction assembly (GO:0007044)3.57617592
32regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.56183016
33intestinal epithelial cell development (GO:0060576)3.55085067
34* regulation of hair follicle development (GO:0051797)3.52442794
35lung-associated mesenchyme development (GO:0060484)3.43975122
36hippo signaling (GO:0035329)3.43919639
37lateral sprouting from an epithelium (GO:0060601)3.38026758
38negative regulation of cell fate specification (GO:0009996)3.34399599
39nuclear pore organization (GO:0006999)3.34375079
40skin development (GO:0043588)3.32110140
41notochord development (GO:0030903)3.31309428
42epidermal cell differentiation (GO:0009913)3.23670146
43nuclear pore complex assembly (GO:0051292)3.22959831
44ventricular cardiac muscle cell action potential (GO:0086005)3.22839815
45* cell junction assembly (GO:0034329)3.22540437
46epithelial cell-cell adhesion (GO:0090136)3.19099109
47focal adhesion assembly (GO:0048041)3.17837604
48cell-substrate adherens junction assembly (GO:0007045)3.17837604
49heterochromatin organization (GO:0070828)3.11595522
50* cell junction organization (GO:0034330)3.11122032
51intermediate filament cytoskeleton organization (GO:0045104)3.10741292
52bone trabecula formation (GO:0060346)3.09943806
53histone H2A monoubiquitination (GO:0035518)3.08666812
54outer ear morphogenesis (GO:0042473)3.07524723
55positive regulation of SMAD protein import into nucleus (GO:0060391)3.06288321
56regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.05297032
57* regulation of epidermis development (GO:0045682)3.04910483
58pre-miRNA processing (GO:0031054)3.03914388
59positive regulation of keratinocyte differentiation (GO:0045618)3.03814133
60mesodermal cell differentiation (GO:0048333)3.03193575
61regulation of cardioblast differentiation (GO:0051890)3.02834978
62interferon-gamma secretion (GO:0072643)3.00071497
63establishment of monopolar cell polarity (GO:0061162)2.98641649
64establishment or maintenance of monopolar cell polarity (GO:0061339)2.98641649
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.97487970
66intermediate filament-based process (GO:0045103)2.96880221
67regulation of water loss via skin (GO:0033561)2.96180325
68adherens junction assembly (GO:0034333)2.94349086
69cell surface receptor signaling pathway involved in heart development (GO:0061311)2.93956883
70G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91971445
71tight junction assembly (GO:0070830)2.91116713
72skin morphogenesis (GO:0043589)2.90673530
73regulation of SMAD protein import into nucleus (GO:0060390)2.89751062
74negative regulation of cartilage development (GO:0061037)2.86117269
75semaphorin-plexin signaling pathway (GO:0071526)2.85144145
76regulation of keratinocyte differentiation (GO:0045616)2.83228688
77mesenchyme development (GO:0060485)2.82556068
78collecting duct development (GO:0072044)2.82087263
79eyelid development in camera-type eye (GO:0061029)2.82032009
80anterior/posterior axis specification, embryo (GO:0008595)2.81618937
81non-canonical Wnt signaling pathway (GO:0035567)2.81362689
82regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.81232652
83wound healing, spreading of epidermal cells (GO:0035313)2.80122774
84anatomical structure regression (GO:0060033)2.79254530
85regulation of epidermal cell differentiation (GO:0045604)2.77708241
86establishment of tissue polarity (GO:0007164)2.77228352
87establishment of planar polarity (GO:0001736)2.77228352
88negative regulation of chondrocyte differentiation (GO:0032331)2.76826697
89L-serine transport (GO:0015825)2.75846651
90apoptotic process involved in morphogenesis (GO:0060561)2.74812660
91establishment of skin barrier (GO:0061436)2.73766803
92embryonic camera-type eye development (GO:0031076)2.73623245
93cell-cell junction assembly (GO:0007043)2.72871357
94cell communication involved in cardiac conduction (GO:0086065)2.72834731
95mesenchymal cell proliferation (GO:0010463)2.69574122
96protein heterotrimerization (GO:0070208)2.69161322
97odontogenesis of dentin-containing tooth (GO:0042475)2.68684005
98protein complex localization (GO:0031503)2.68209599
99mesenchymal to epithelial transition (GO:0060231)2.67192131
100keratinocyte development (GO:0003334)2.67181322
101gap junction assembly (GO:0016264)2.67103717
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.65560504
103protein localization to kinetochore (GO:0034501)2.64720307
104regulation of heart rate by cardiac conduction (GO:0086091)2.63912979
105odontogenesis (GO:0042476)2.62445375
106oocyte development (GO:0048599)2.62189375
107branching involved in mammary gland duct morphogenesis (GO:0060444)2.61493562
108apical protein localization (GO:0045176)2.61313099
109establishment of epithelial cell polarity (GO:0090162)2.59755291
110mitotic nuclear envelope disassembly (GO:0007077)2.59642313
111negative regulation of keratinocyte proliferation (GO:0010839)2.59482257
112renal system development (GO:0072001)2.58749956
113mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58605622
114regulation of establishment of planar polarity (GO:0090175)2.58324338
115bone morphogenesis (GO:0060349)2.57875872
116regulation of cell fate specification (GO:0042659)2.57597783
117atrioventricular valve morphogenesis (GO:0003181)2.57580469
118trophoblast giant cell differentiation (GO:0060707)2.57577562
119regulation of G0 to G1 transition (GO:0070316)2.56853621
120negative regulation of DNA repair (GO:0045738)2.56643114
121regulation of heart morphogenesis (GO:2000826)2.55926335
122axis elongation (GO:0003401)2.55886927
123mitotic G1 DNA damage checkpoint (GO:0031571)2.55607436
124epithelium development (GO:0060429)2.54577480
125keratinocyte differentiation (GO:0030216)2.54317790
126mammary gland development (GO:0030879)2.53787501
127endodermal cell differentiation (GO:0035987)2.53175388
128cranial suture morphogenesis (GO:0060363)2.51222646
129dorsal/ventral axis specification (GO:0009950)2.51073559
130negative regulation of cell fate commitment (GO:0010454)2.50931854
131asymmetric protein localization (GO:0008105)2.50546331
132regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.48706311
133regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.47069018
134morphogenesis of an epithelial fold (GO:0060571)2.46996799
135proximal/distal pattern formation (GO:0009954)2.46718478
136cochlea morphogenesis (GO:0090103)2.45803678
137cartilage morphogenesis (GO:0060536)2.45721413
138nuclear envelope disassembly (GO:0051081)2.45541032
139membrane disassembly (GO:0030397)2.45541032
140branching involved in salivary gland morphogenesis (GO:0060445)2.45111839
141morphogenesis of embryonic epithelium (GO:0016331)2.44596667
142ectoderm development (GO:0007398)2.43689814
143positive regulation of hormone biosynthetic process (GO:0046886)2.43180921
144endocardial cushion development (GO:0003197)2.42732269
145cell differentiation involved in embryonic placenta development (GO:0060706)2.42520001
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42439577
147embryonic cranial skeleton morphogenesis (GO:0048701)2.42208840
148cardiac right ventricle morphogenesis (GO:0003215)2.41916215
149DNA replication-dependent nucleosome assembly (GO:0006335)2.41517798
150DNA replication-dependent nucleosome organization (GO:0034723)2.41517798
151regulation of stem cell maintenance (GO:2000036)2.40826173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.55437684
2E2F7_22180533_ChIP-Seq_HELA_Human4.71862332
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.24852008
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.06722255
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.06722255
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.06722255
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67427733
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.52800321
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43831418
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.40880777
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35634195
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25550339
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.24764528
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21187363
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20548608
16AR_21909140_ChIP-Seq_LNCAP_Human2.19062968
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18132640
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.17418515
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.17195315
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.15635533
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08694484
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08433906
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07098516
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03362859
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95944496
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93029995
27ZNF263_19887448_ChIP-Seq_K562_Human1.85017812
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83182333
29TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74289011
30* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69762623
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68333746
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.64607397
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63577878
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63250078
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.62889558
36* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62545357
37* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56799026
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54747837
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54515985
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52905400
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52905400
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52833664
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51915737
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50793452
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46983985
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46820587
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45704150
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45457822
49* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44652049
50* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40923728
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39278619
52ATF3_27146783_Chip-Seq_COLON_Human1.38977781
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37696353
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37504332
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.37202407
56EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37078795
57* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34784468
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33335865
59* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31318990
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30663770
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.30387995
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.29961590
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29778208
64* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27432527
65CLOCK_20551151_ChIP-Seq_293T_Human1.26356366
66* TP63_23658742_ChIP-Seq_EP156T_Human1.25981591
67SOX2_20726797_ChIP-Seq_SW620_Human1.25438202
68* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24692152
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22647504
70* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21582227
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21569100
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21502710
73* TP63_22573176_ChIP-Seq_HFKS_Human1.21117420
74* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21014274
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.19743434
76* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19572439
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.19553409
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18508850
79* ESR2_21235772_ChIP-Seq_MCF-7_Human1.18353852
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17786495
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.17669322
82* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16653765
83KLF5_25053715_ChIP-Seq_YYC3_Human1.15428941
84MYC_22102868_ChIP-Seq_BL_Human1.15099940
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14523359
86* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13913768
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.13861280
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13856438
89* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12814553
90XRN2_22483619_ChIP-Seq_HELA_Human1.12392572
91* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10986441
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.10443061
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.07221730
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07151228
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06100201
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06047032
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05673649
98CHD1_26751641_Chip-Seq_LNCaP_Human1.05237132
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03241917
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02160192
101* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01210986
102GATA6_25053715_ChIP-Seq_YYC3_Human1.00990956
103* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99689010
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.99496058
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98675114
106* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98006900
107* FOXO3_23340844_ChIP-Seq_DLD1_Human0.97826475
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96558776
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.96094815
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.95703512
111TP53_22127205_ChIP-Seq_IMR90_Human0.93217520
112KAP1_27257070_Chip-Seq_ESCs_Mouse0.93165125
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93036889
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92721896
115MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92465040
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90656561
117AHR_22903824_ChIP-Seq_MCF-7_Human0.87237045
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83141940
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.82358581
120* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82344036
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.81124646
122GATA4_25053715_ChIP-Seq_YYC3_Human0.79741348
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77447313
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71604310
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65598556
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.65423109
127* CJUN_26792858_Chip-Seq_BT549_Human0.63819148
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.63706784
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62685297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.50102556
2MP0003941_abnormal_skin_development3.10777682
3MP0009053_abnormal_anal_canal2.97085151
4MP0010030_abnormal_orbit_morphology2.84189711
5MP0000537_abnormal_urethra_morphology2.69079390
6MP0000579_abnormal_nail_morphology2.66552175
7MP0003123_paternal_imprinting2.63007674
8MP0005275_abnormal_skin_tensile2.56407494
9MP0004381_abnormal_hair_follicle2.50225415
10MP0000383_abnormal_hair_follicle2.45845225
11MP0010234_abnormal_vibrissa_follicle2.45381311
12MP0002796_impaired_skin_barrier2.39258601
13MP0003566_abnormal_cell_adhesion2.36928795
14MP0002254_reproductive_system_inflammat2.31544388
15MP0004272_abnormal_basement_membrane2.28207828
16MP0005409_darkened_coat_color2.22354468
17MP0010678_abnormal_skin_adnexa2.14490499
18MP0002098_abnormal_vibrissa_morphology2.04162429
19MP0001849_ear_inflammation1.95494456
20MP0000762_abnormal_tongue_morphology1.93312332
21MP0003122_maternal_imprinting1.90466030
22MP0003453_abnormal_keratinocyte_physiol1.84064105
23MP0002060_abnormal_skin_morphology1.82679138
24MP0010352_gastrointestinal_tract_polyps1.80725908
25MP0005367_renal/urinary_system_phenotyp1.80659600
26MP0000516_abnormal_urinary_system1.80659600
27MP0004264_abnormal_extraembryonic_tissu1.79373686
28MP0003121_genomic_imprinting1.76935294
29MP0003937_abnormal_limbs/digits/tail_de1.72159108
30MP0003385_abnormal_body_wall1.71277755
31MP0000647_abnormal_sebaceous_gland1.71126023
32MP0000467_abnormal_esophagus_morphology1.68130151
33MP0008438_abnormal_cutaneous_collagen1.67968312
34MP0005501_abnormal_skin_physiology1.64220335
35MP0005623_abnormal_meninges_morphology1.64013755
36MP0000566_synostosis1.59466461
37MP0005076_abnormal_cell_differentiation1.56419079
38MP0005023_abnormal_wound_healing1.55237614
39MP0000377_abnormal_hair_follicle1.54261013
40MP0006054_spinal_hemorrhage1.53992655
41MP0000678_abnormal_parathyroid_gland1.52302165
42MP0004957_abnormal_blastocyst_morpholog1.51628860
43MP0001216_abnormal_epidermal_layer1.51204173
44MP0003567_abnormal_fetal_cardiomyocyte1.48353828
45MP0004197_abnormal_fetal_growth/weight/1.45253118
46MP0000427_abnormal_hair_cycle1.43868871
47MP0002282_abnormal_trachea_morphology1.42560993
48MP0003315_abnormal_perineum_morphology1.41923991
49MP0003755_abnormal_palate_morphology1.40042838
50MP0001346_abnormal_lacrimal_gland1.36791711
51MP0002249_abnormal_larynx_morphology1.35196837
52MP0005257_abnormal_intraocular_pressure1.33431750
53MP0002084_abnormal_developmental_patter1.33028062
54MP0003942_abnormal_urinary_system1.32715023
55MP0003119_abnormal_digestive_system1.32303369
56MP0000428_abnormal_craniofacial_morphol1.32082002
57MP0002234_abnormal_pharynx_morphology1.29883067
58MP0002932_abnormal_joint_morphology1.24659497
59MP0002085_abnormal_embryonic_tissue1.23450717
60MP0002086_abnormal_extraembryonic_tissu1.22802808
61MP0010094_abnormal_chromosome_stability1.22550153
62MP0008007_abnormal_cellular_replicative1.22449437
63MP0005503_abnormal_tendon_morphology1.20973588
64MP0005508_abnormal_skeleton_morphology1.20226415
65MP0002111_abnormal_tail_morphology1.19681158
66MP0003935_abnormal_craniofacial_develop1.19097606
67MP0003111_abnormal_nucleus_morphology1.18299654
68MP0003115_abnormal_respiratory_system1.16605749
69MP0003693_abnormal_embryo_hatching1.16043263
70MP0001293_anophthalmia1.15357751
71MP0009250_abnormal_appendicular_skeleto1.15345081
72MP0005380_embryogenesis_phenotype1.15068799
73MP0001672_abnormal_embryogenesis/_devel1.15068799
74MP0000733_abnormal_muscle_development1.15053764
75MP0002233_abnormal_nose_morphology1.14478995
76MP0000534_abnormal_ureter_morphology1.14288001
77MP0000432_abnormal_head_morphology1.12133868
78MP0001730_embryonic_growth_arrest1.11831232
79MP0004782_abnormal_surfactant_physiolog1.10691783
80MP0010771_integument_phenotype1.10453009
81MP0001697_abnormal_embryo_size1.08905804
82MP0003890_abnormal_embryonic-extraembry1.08428329
83MP0000049_abnormal_middle_ear1.08162342
84MP0002653_abnormal_ependyma_morphology1.07545373
85MP0003077_abnormal_cell_cycle1.06826489
86MP0005187_abnormal_penis_morphology1.05962006
87* MP0000627_abnormal_mammary_gland1.05953896
88MP0000350_abnormal_cell_proliferation1.05943168
89MP0002088_abnormal_embryonic_growth/wei1.04695048
90MP0003984_embryonic_growth_retardation1.03656875
91MP0001340_abnormal_eyelid_morphology1.02414161
92MP0001243_abnormal_dermal_layer1.00109121
93MP0002697_abnormal_eye_size0.99768877
94MP0009384_cardiac_valve_regurgitation0.99158292
95MP0005248_abnormal_Harderian_gland0.97407779
96MP0002938_white_spotting0.96926270
97MP0008932_abnormal_embryonic_tissue0.94908997
98MP0003718_maternal_effect0.93028755
99MP0000367_abnormal_coat/_hair0.91753101
100MP0005377_hearing/vestibular/ear_phenot0.90713569
101MP0003878_abnormal_ear_physiology0.90713569
102MP0001286_abnormal_eye_development0.90503690
103MP0008260_abnormal_autophagy0.90110462
104MP0002116_abnormal_craniofacial_bone0.88176196
105MP0002092_abnormal_eye_morphology0.87288899
106MP0001299_abnormal_eye_distance/0.86832353
107MP0002109_abnormal_limb_morphology0.86328791
108MP0001191_abnormal_skin_condition0.84770303
109MP0005499_abnormal_olfactory_system0.84634075
110MP0005394_taste/olfaction_phenotype0.84634075
111MP0002877_abnormal_melanocyte_morpholog0.84484942
112MP0002089_abnormal_postnatal_growth/wei0.84396548
113MP0000462_abnormal_digestive_system0.83079536
114MP0009672_abnormal_birth_weight0.83022292
115MP0009931_abnormal_skin_appearance0.81922740
116MP0008789_abnormal_olfactory_epithelium0.81561753
117MP0002177_abnormal_outer_ear0.81407675
118MP0004019_abnormal_vitamin_homeostasis0.79624950
119MP0002925_abnormal_cardiovascular_devel0.78959818
120MP0002114_abnormal_axial_skeleton0.78490929
121MP0009780_abnormal_chondrocyte_physiolo0.72224549
122MP0005197_abnormal_uvea_morphology0.70288873
123MP0004885_abnormal_endolymph0.70089303
124MP0003136_yellow_coat_color0.61958554
125MP0001881_abnormal_mammary_gland0.60358531
126MP0005075_abnormal_melanosome_morpholog0.60225491
127MP0004947_skin_inflammation0.59283285
128MP0003950_abnormal_plasma_membrane0.58483657
129MP0000538_abnormal_urinary_bladder0.51862654
130MP0005193_abnormal_anterior_eye0.50501185
131MP0009379_abnormal_foot_pigmentation0.49785377
132MP0000470_abnormal_stomach_morphology0.47489513
133MP0000858_altered_metastatic_potential0.46356606
134MP0004858_abnormal_nervous_system0.45932777
135MP0006138_congestive_heart_failure0.45258993

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)5.02594446
2Fragile nails (HP:0001808)4.73780514
3Atrophic scars (HP:0001075)4.58839615
4Right ventricular cardiomyopathy (HP:0011663)3.98552066
5Woolly hair (HP:0002224)3.92907643
6Hypoplasia of dental enamel (HP:0006297)3.76101061
7Esophageal atresia (HP:0002032)3.63574837
8Shallow orbits (HP:0000586)3.55313539
9Onycholysis (HP:0001806)3.48119121
10Abnormality of the salivary glands (HP:0010286)3.42886323
11Plantar hyperkeratosis (HP:0007556)3.21528826
12Protrusio acetabuli (HP:0003179)3.20726011
13Oral leukoplakia (HP:0002745)3.05567502
14Premature rupture of membranes (HP:0001788)3.01381976
15Popliteal pterygium (HP:0009756)3.00856384
16* Hypotrichosis (HP:0001006)2.94311890
17Nail dystrophy (HP:0008404)2.91841008
18* Sparse eyelashes (HP:0000653)2.85252589
19Short 4th metacarpal (HP:0010044)2.76927510
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76927510
21* Abnormal hair laboratory examination (HP:0003328)2.76077670
22Ankyloglossia (HP:0010296)2.69241390
23Fragile skin (HP:0001030)2.66972372
24Amniotic constriction ring (HP:0009775)2.66496288
25Abnormality of placental membranes (HP:0011409)2.66496288
26Abnormality of the 4th metacarpal (HP:0010012)2.66073396
27Dry hair (HP:0011359)2.56826429
28Renal duplication (HP:0000075)2.51160382
29Ankle contracture (HP:0006466)2.50812978
30Aplasia cutis congenita (HP:0001057)2.48936090
31Abnormality of secondary sexual hair (HP:0009888)2.45760655
32Abnormality of the axillary hair (HP:0100134)2.45760655
33Oligodontia (HP:0000677)2.44125759
34* Sparse scalp hair (HP:0002209)2.38706262
35Alopecia of scalp (HP:0002293)2.38684413
36Hypodontia (HP:0000668)2.35946559
37Corneal erosion (HP:0200020)2.33997294
38Fatigable weakness (HP:0003473)2.33896964
39Abnormality of the neuromuscular junction (HP:0003398)2.33896964
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.33557391
41Labial hypoplasia (HP:0000066)2.32204315
42Abnormality of the lacrimal duct (HP:0011481)2.30991016
43Short 5th finger (HP:0009237)2.30738134
44Palmoplantar keratoderma (HP:0000982)2.30234153
45Breast hypoplasia (HP:0003187)2.29301973
46Short middle phalanx of the 5th finger (HP:0004220)2.28423265
47Absent hair (HP:0002298)2.26567038
48Hypoplastic female external genitalia (HP:0012815)2.23313123
49* Carious teeth (HP:0000670)2.22982689
50Hypoplastic labia majora (HP:0000059)2.21859021
51Natal tooth (HP:0000695)2.21377538
52Septate vagina (HP:0001153)2.19761838
53Abnormality of nail color (HP:0100643)2.17122860
54Abnormality of the dental root (HP:0006486)2.16778525
55Taurodontia (HP:0000679)2.16778525
56Abnormality of permanent molar morphology (HP:0011071)2.16778525
57Congenital ichthyosiform erythroderma (HP:0007431)2.15509142
58Lip pit (HP:0100267)2.15076927
59Abnormality of oral frenula (HP:0000190)2.13742497
60Deviation of the hallux (HP:0010051)2.13061702
61Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.12221636
62* Selective tooth agenesis (HP:0001592)2.12072377
63Gastrointestinal atresia (HP:0002589)2.11832527
64* Pili torti (HP:0003777)2.11816643
65Ectropion (HP:0000656)2.11420897
66Nasolacrimal duct obstruction (HP:0000579)2.09762516
67Down-sloping shoulders (HP:0200021)2.06187165
68Asymmetry of the thorax (HP:0001555)2.06122131
69Ridged nail (HP:0001807)2.05669555
70Atresia of the external auditory canal (HP:0000413)2.04725901
71Palmoplantar hyperkeratosis (HP:0000972)2.04346241
72Palmar hyperkeratosis (HP:0010765)2.04192723
73Split foot (HP:0001839)2.00075093
74Pterygium (HP:0001059)1.99957381
75Ventricular tachycardia (HP:0004756)1.99841122
76Ureteral stenosis (HP:0000071)1.99397515
77Broad thumb (HP:0011304)1.98375460
78Hypoplasia of the uterus (HP:0000013)1.98010792
79Abnormality of the labia majora (HP:0012881)1.97911211
80Abnormality of the nasolacrimal system (HP:0000614)1.97695478
81Abnormality of molar (HP:0011077)1.97471229
82Abnormality of molar morphology (HP:0011070)1.97471229
83Abnormality of the distal phalanges of the toes (HP:0010182)1.97054518
84Hallux valgus (HP:0001822)1.96607879
85Deviation of the thumb (HP:0009603)1.96078403
86Absent eyelashes (HP:0000561)1.94907992
87Abnormality of the parietal bone (HP:0002696)1.92242191
88Abnormality of the fingernails (HP:0001231)1.91566020
89Bladder diverticulum (HP:0000015)1.90065318
90Missing ribs (HP:0000921)1.89113643
91Abnormality of the dental pulp (HP:0006479)1.88370463
92Short phalanx of the thumb (HP:0009660)1.83246836
93Ulnar bowing (HP:0003031)1.82406377
94Abnormal blistering of the skin (HP:0008066)1.82274071
95Morphological abnormality of the middle ear (HP:0008609)1.82184115
96Advanced eruption of teeth (HP:0006288)1.81445532
97Abnormality of the labia minora (HP:0012880)1.81407520
98Colon cancer (HP:0003003)1.81371541
99Coronal craniosynostosis (HP:0004440)1.80981957
100Ureteral obstruction (HP:0006000)1.80702034
101Amelogenesis imperfecta (HP:0000705)1.80701000
102Erythema (HP:0010783)1.80656422
103Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80501688
104Laryngomalacia (HP:0001601)1.80446039
105Increased connective tissue (HP:0009025)1.78902484
106Skin pits (HP:0100276)1.78501787
107Death in infancy (HP:0001522)1.78063479
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.76218005
109Synostosis of carpal bones (HP:0005048)1.75264076
110Carpal synostosis (HP:0009702)1.74846294
111Hyperhidrosis (HP:0000975)1.73907202
112Abnormality of the 2nd finger (HP:0004100)1.73169983
113Proximal placement of thumb (HP:0009623)1.72911396
114Duplicated collecting system (HP:0000081)1.72221627
115Cutaneous finger syndactyly (HP:0010554)1.71797644
116Bronchomalacia (HP:0002780)1.71551436
117Hypohidrosis (HP:0000966)1.71087701
118Trismus (HP:0000211)1.70416468
119Abnormality of the fetal cardiovascular system (HP:0010948)1.70153015
120Abnormal umbilical cord blood vessels (HP:0011403)1.70153015
121Single umbilical artery (HP:0001195)1.70153015
122Abnormality of the phalanges of the hallux (HP:0010057)1.69349116
123Absent radius (HP:0003974)1.68389978
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67944912
125Thick nail (HP:0001805)1.67785399
126Follicular hyperkeratosis (HP:0007502)1.67746895
127Squamous cell carcinoma (HP:0002860)1.67564625
128Mitral valve prolapse (HP:0001634)1.67276058
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67045265
130Short 1st metacarpal (HP:0010034)1.67045265
131Supernumerary ribs (HP:0005815)1.66079266
132Concave nail (HP:0001598)1.65359957
133Broad toe (HP:0001837)1.64470117
134Abnormality of the labia (HP:0000058)1.64371606
135Anonychia (HP:0001798)1.63723710
136Cerebral aneurysm (HP:0004944)1.63367993
137Multifactorial inheritance (HP:0001426)1.62801343
138Dehydration (HP:0001944)1.62533495
139Rectal prolapse (HP:0002035)1.62493607
140Curly hair (HP:0002212)1.61885345
141Broad phalanges of the hand (HP:0009768)1.61518188
142Depressed nasal tip (HP:0000437)1.60501752
143Genu recurvatum (HP:0002816)1.60359992
144Abnormality of the gastric mucosa (HP:0004295)1.60241992
145Hyperacusis (HP:0010780)1.60152170
146Blepharitis (HP:0000498)1.59983856
147Shawl scrotum (HP:0000049)1.59682874
148Skin tags (HP:0010609)1.59629523
149Neonatal short-limb short stature (HP:0008921)1.59626199
150Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59441353
151Fused cervical vertebrae (HP:0002949)1.58982596
152Erythroderma (HP:0001019)1.58936475
153Absent forearm bone (HP:0003953)1.58599101
154Aplasia involving forearm bones (HP:0009822)1.58599101
155Abnormal number of incisors (HP:0011064)1.58193081
156Poikiloderma (HP:0001029)1.57005738
157Aplasia/hypoplasia of the uterus (HP:0008684)1.55798578
158Cheilitis (HP:0100825)1.55537813
159Epidermoid cyst (HP:0200040)1.49519783
160Premature loss of primary teeth (HP:0006323)1.45771095
161Vertebral arch anomaly (HP:0008438)1.43679531
162Ureteral duplication (HP:0000073)1.42697129
163Non-midline cleft lip (HP:0100335)1.41253618
164Xerostomia (HP:0000217)1.39984209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.67142700
2LATS13.75065629
3EPHA23.40917477
4RPS6KB23.25900343
5PKN23.12869356
6CDK123.01781293
7MAP3K92.97109090
8LATS22.83200917
9ARAF2.68609367
10NTRK12.46427919
11TRIB32.44174243
12PLK42.40269453
13EPHB22.28180195
14STK38L2.26947089
15SMG12.11804899
16MAP3K102.05808930
17STK242.04224175
18EEF2K1.99157735
19PDGFRA1.94153455
20FER1.93650728
21TTK1.89516120
22MAPKAPK31.84850671
23DDR21.84168954
24CDC71.67550708
25MAP3K21.67037100
26STK101.66329497
27STK31.60724744
28CDK71.52649213
29PAK41.49187193
30MAP3K31.48501410
31PTK61.45681272
32LRRK21.43658461
33PBK1.41226561
34PIM21.37039475
35TTN1.35342218
36PASK1.33805264
37PTK21.31596873
38MET1.30954164
39FGFR11.29758156
40MTOR1.27886194
41TGFBR11.27808197
42NEK21.27750702
43ICK1.25464401
44MKNK11.25227070
45WEE11.24791379
46MAP3K81.20662031
47PAK21.20048173
48LMTK21.19024793
49CDK61.13952538
50TSSK61.11886733
51TESK11.11687439
52RIPK11.10797761
53MST41.04469721
54BMX1.01454616
55RPS6KA40.99088100
56NME20.96848489
57NME10.91499049
58AURKB0.91279710
59PRKCI0.91109325
60PLK10.91094669
61ERN10.90988343
62NEK10.88484613
63MAP3K120.87977581
64TRPM70.87012288
65SRPK10.86097998
66TYRO30.83443950
67PLK30.82712133
68BRAF0.82479411
69CDK40.80368368
70ERBB20.80216465
71FGFR20.78878203
72BRD40.78868075
73PNCK0.78268415
74RPS6KA20.77988011
75ALK0.77265425
76CHEK20.76610378
77BRSK20.74691992
78DYRK30.72464085
79ERBB40.72145900
80CHEK10.69911758
81MKNK20.69168863
82BUB10.68992930
83CDK90.68767436
84LIMK10.66671518
85AKT20.66385888
86MAP2K20.62443094
87KSR20.60825370
88VRK20.60452205
89TAF10.59292119
90ATR0.58915125
91NEK60.58078257
92ATM0.57448104
93CDC42BPA0.57371033
94ILK0.54026182
95EPHB10.53923818
96PDGFRB0.53676698
97STK380.52065079
98CDK20.51886620
99MAPKAPK20.51864066
100ROCK20.51348025
101BCR0.50037024
102DYRK1B0.49946306
103RPS6KA10.48810085
104MAP3K60.47803755
105MELK0.47676728
106AURKA0.46841968
107CSNK1E0.46602893
108PAK10.46157382
109FLT30.43012295
110EPHA30.42689861
111SIK10.42260953
112MAPK10.40847782
113ERBB30.40693791
114TRIM280.40207011
115CDK10.39053921
116PRKG20.38755231
117EIF2AK20.37932731
118ROCK10.37679453
119PRKD30.37038601
120CSNK1D0.36919716
121ZAK0.36830616
122CAMK1D0.36243983
123DMPK0.35818244
124MAPK150.35223317
125RET0.34408352
126MUSK0.33095298
127AKT10.32960929
128TAOK10.32567774
129FGFR40.32052338
130CSNK1A1L0.30619971
131KSR10.30102371
132CSNK1G10.29113621
133MAPKAPK50.27502953
134RPS6KL10.25125323
135RPS6KC10.25125323
136CSNK1G30.25024578
137RAF10.23748013
138CASK0.22159121
139CAMK1G0.21172470
140RPS6KA60.20749953
141PRKCE0.20670306
142RPS6KB10.18044650

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.48774679
2Hippo signaling pathway_Homo sapiens_hsa043903.02967997
3Hedgehog signaling pathway_Homo sapiens_hsa043402.83944172
4ECM-receptor interaction_Homo sapiens_hsa045122.64000494
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.39155732
6Adherens junction_Homo sapiens_hsa045202.35058541
7RNA transport_Homo sapiens_hsa030132.31140933
8Steroid biosynthesis_Homo sapiens_hsa001002.31097455
9Cell cycle_Homo sapiens_hsa041102.21388157
10Spliceosome_Homo sapiens_hsa030402.14851241
11TGF-beta signaling pathway_Homo sapiens_hsa043502.08801936
12Small cell lung cancer_Homo sapiens_hsa052221.99915761
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96777415
14Proteoglycans in cancer_Homo sapiens_hsa052051.95604610
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93234148
16DNA replication_Homo sapiens_hsa030301.91571228
17MicroRNAs in cancer_Homo sapiens_hsa052061.90462244
18Tight junction_Homo sapiens_hsa045301.82812822
19Notch signaling pathway_Homo sapiens_hsa043301.80375742
20Mismatch repair_Homo sapiens_hsa034301.77137602
21Focal adhesion_Homo sapiens_hsa045101.75289297
22Bladder cancer_Homo sapiens_hsa052191.69945321
23p53 signaling pathway_Homo sapiens_hsa041151.69409828
24Thyroid cancer_Homo sapiens_hsa052161.65441322
25mRNA surveillance pathway_Homo sapiens_hsa030151.60510362
26Ribosome_Homo sapiens_hsa030101.52860112
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51810347
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49689034
29Wnt signaling pathway_Homo sapiens_hsa043101.48973942
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47149010
31Nucleotide excision repair_Homo sapiens_hsa034201.41285407
32Base excision repair_Homo sapiens_hsa034101.39516513
33HTLV-I infection_Homo sapiens_hsa051661.37866652
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37643992
35Pathways in cancer_Homo sapiens_hsa052001.34783149
36One carbon pool by folate_Homo sapiens_hsa006701.34167181
37Amoebiasis_Homo sapiens_hsa051461.27070833
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25022166
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22311507
40Sphingolipid metabolism_Homo sapiens_hsa006001.18221272
41Galactose metabolism_Homo sapiens_hsa000521.15880027
42Chronic myeloid leukemia_Homo sapiens_hsa052201.15175811
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.13936882
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12941051
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10590220
46Viral carcinogenesis_Homo sapiens_hsa052031.09412611
47Protein digestion and absorption_Homo sapiens_hsa049741.08983343
48RNA degradation_Homo sapiens_hsa030181.08736331
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.08650773
50Endometrial cancer_Homo sapiens_hsa052131.07138006
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06551303
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.05543005
53Melanogenesis_Homo sapiens_hsa049161.05172400
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05009930
55Prostate cancer_Homo sapiens_hsa052151.04592425
56Basal transcription factors_Homo sapiens_hsa030221.02629627
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00054610
58N-Glycan biosynthesis_Homo sapiens_hsa005100.99840667
59Colorectal cancer_Homo sapiens_hsa052100.98463820
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98437693
61Fanconi anemia pathway_Homo sapiens_hsa034600.98081728
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96970440
63Homologous recombination_Homo sapiens_hsa034400.96715710
64Axon guidance_Homo sapiens_hsa043600.94556445
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92669680
66Melanoma_Homo sapiens_hsa052180.92459013
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91657061
68Biosynthesis of amino acids_Homo sapiens_hsa012300.89535938
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88895634
70Antigen processing and presentation_Homo sapiens_hsa046120.85930534
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85747061
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.85437650
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84229890
74Dilated cardiomyopathy_Homo sapiens_hsa054140.83680140
75Oocyte meiosis_Homo sapiens_hsa041140.82829315
76Systemic lupus erythematosus_Homo sapiens_hsa053220.82609598
77Viral myocarditis_Homo sapiens_hsa054160.80974362
78RNA polymerase_Homo sapiens_hsa030200.80665851
79Rap1 signaling pathway_Homo sapiens_hsa040150.78807238
80Pancreatic cancer_Homo sapiens_hsa052120.76824085
81mTOR signaling pathway_Homo sapiens_hsa041500.76322186
82Toxoplasmosis_Homo sapiens_hsa051450.75032144
83Renal cell carcinoma_Homo sapiens_hsa052110.74746973
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69803527
85Acute myeloid leukemia_Homo sapiens_hsa052210.68802020
86Lysine degradation_Homo sapiens_hsa003100.66663732
87VEGF signaling pathway_Homo sapiens_hsa043700.66499217
88Insulin signaling pathway_Homo sapiens_hsa049100.66388822
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65085556
90Ovarian steroidogenesis_Homo sapiens_hsa049130.63197077
91Vitamin digestion and absorption_Homo sapiens_hsa049770.63010856
92Herpes simplex infection_Homo sapiens_hsa051680.62860166
93Epstein-Barr virus infection_Homo sapiens_hsa051690.61238192
94Phenylalanine metabolism_Homo sapiens_hsa003600.61106896
95Inositol phosphate metabolism_Homo sapiens_hsa005620.60357406
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60154489
97Proteasome_Homo sapiens_hsa030500.59671347
98HIF-1 signaling pathway_Homo sapiens_hsa040660.58457947
99Non-small cell lung cancer_Homo sapiens_hsa052230.57340873
100Selenocompound metabolism_Homo sapiens_hsa004500.56609572
101Dorso-ventral axis formation_Homo sapiens_hsa043200.53628556
102Fructose and mannose metabolism_Homo sapiens_hsa000510.50925612
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50621717
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50331716
105Shigellosis_Homo sapiens_hsa051310.49394400
106Apoptosis_Homo sapiens_hsa042100.48482490
107Phototransduction_Homo sapiens_hsa047440.47653552
108Prion diseases_Homo sapiens_hsa050200.46563677
109Estrogen signaling pathway_Homo sapiens_hsa049150.45150676
110Pentose phosphate pathway_Homo sapiens_hsa000300.44901177
111Fatty acid elongation_Homo sapiens_hsa000620.44582423
112Glioma_Homo sapiens_hsa052140.44229511
113Vitamin B6 metabolism_Homo sapiens_hsa007500.43593882
114Non-homologous end-joining_Homo sapiens_hsa034500.42756455
115Ether lipid metabolism_Homo sapiens_hsa005650.42250477
116Linoleic acid metabolism_Homo sapiens_hsa005910.41754657
117FoxO signaling pathway_Homo sapiens_hsa040680.39157549
118Hepatitis B_Homo sapiens_hsa051610.37414346
119Arginine and proline metabolism_Homo sapiens_hsa003300.36732502
120Pyrimidine metabolism_Homo sapiens_hsa002400.35498989
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35332029
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34619161
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.33772610
124ErbB signaling pathway_Homo sapiens_hsa040120.31838544
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30836853
126Ras signaling pathway_Homo sapiens_hsa040140.30730930
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30390288
128Insulin resistance_Homo sapiens_hsa049310.29805195
129TNF signaling pathway_Homo sapiens_hsa046680.29638567
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.28011278
131Endocytosis_Homo sapiens_hsa041440.27025176
132AMPK signaling pathway_Homo sapiens_hsa041520.26055275

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