CDH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.51804913
2layer formation in cerebral cortex (GO:0021819)5.25120664
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82080255
4vocalization behavior (GO:0071625)4.78460734
5protein localization to synapse (GO:0035418)4.46212421
6regulation of glutamate receptor signaling pathway (GO:1900449)4.42028667
7postsynaptic membrane organization (GO:0001941)4.35869846
8neuron recognition (GO:0008038)4.32754405
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29129628
10cell migration in hindbrain (GO:0021535)4.28789159
11synaptic vesicle exocytosis (GO:0016079)4.27463408
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18934358
13locomotory exploration behavior (GO:0035641)4.13152157
14dendritic spine morphogenesis (GO:0060997)4.12938240
15axonal fasciculation (GO:0007413)4.12838843
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10109496
17innervation (GO:0060384)4.02533447
18proline transport (GO:0015824)3.88727336
19neurotransmitter-gated ion channel clustering (GO:0072578)3.87628368
20pyrimidine nucleobase catabolic process (GO:0006208)3.79918585
21auditory behavior (GO:0031223)3.76853704
22positive regulation of synapse assembly (GO:0051965)3.73652390
23synaptic vesicle maturation (GO:0016188)3.72943651
24regulation of synapse structural plasticity (GO:0051823)3.64238356
25positive regulation of synapse maturation (GO:0090129)3.61471018
26dendrite morphogenesis (GO:0048813)3.55877949
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55848421
28establishment of mitochondrion localization (GO:0051654)3.52096918
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.51753288
30exploration behavior (GO:0035640)3.51312098
31behavioral response to nicotine (GO:0035095)3.50088601
32presynaptic membrane assembly (GO:0097105)3.50022055
33regulation of synaptic vesicle exocytosis (GO:2000300)3.48465922
34spinal cord development (GO:0021510)3.45714445
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45276037
36glutamate receptor signaling pathway (GO:0007215)3.42671720
37synapse assembly (GO:0007416)3.40130650
38central nervous system projection neuron axonogenesis (GO:0021952)3.39757129
39response to auditory stimulus (GO:0010996)3.35094067
40regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31094934
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30408117
42glutamate secretion (GO:0014047)3.29046843
43limb bud formation (GO:0060174)3.26766248
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25601645
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.24876678
46synaptic transmission, glutamatergic (GO:0035249)3.24413837
47neurotransmitter secretion (GO:0007269)3.23789472
48establishment of nucleus localization (GO:0040023)3.19365663
49cell proliferation in forebrain (GO:0021846)3.16676467
50regulation of synapse assembly (GO:0051963)3.14789501
51regulation of axon extension involved in axon guidance (GO:0048841)3.10851716
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.10182078
53dendrite development (GO:0016358)3.07780702
54regulation of synapse organization (GO:0050807)3.07296233
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07288558
56presynaptic membrane organization (GO:0097090)3.06290309
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.05693339
58synapse organization (GO:0050808)3.03026580
59transmission of nerve impulse (GO:0019226)3.03023694
60regulation of dendritic spine morphogenesis (GO:0061001)3.02887695
61neuron-neuron synaptic transmission (GO:0007270)3.02826602
62mitochondrion transport along microtubule (GO:0047497)3.02794074
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02794074
64startle response (GO:0001964)3.02344544
65regulation of axon guidance (GO:1902667)3.00550616
66mechanosensory behavior (GO:0007638)2.98343466
67regulation of respiratory system process (GO:0044065)2.98083613
68neuron projection extension (GO:1990138)2.95703756
69regulation of synaptic vesicle transport (GO:1902803)2.95506447
70synaptic vesicle endocytosis (GO:0048488)2.95108835
71prepulse inhibition (GO:0060134)2.93777016
72regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93755461
73regulation of synapse maturation (GO:0090128)2.90563973
74hippocampus development (GO:0021766)2.90235249
75cerebellar granule cell differentiation (GO:0021707)2.89937476
76gamma-aminobutyric acid transport (GO:0015812)2.89098703
77regulation of neuronal synaptic plasticity (GO:0048168)2.88605803
78axon extension (GO:0048675)2.87002326
79nucleobase catabolic process (GO:0046113)2.86166974
80lateral sprouting from an epithelium (GO:0060601)2.85261435
81calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.82910245
82retinal ganglion cell axon guidance (GO:0031290)2.81621868
83membrane assembly (GO:0071709)2.81455447
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81216125
85positive regulation of dendritic spine development (GO:0060999)2.77872626
86* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.77131993
87negative regulation of microtubule polymerization (GO:0031115)2.76770000
88neuronal action potential propagation (GO:0019227)2.76141576
89neuronal stem cell maintenance (GO:0097150)2.75455134
90mating behavior (GO:0007617)2.75111804
91central nervous system neuron axonogenesis (GO:0021955)2.74545293
92retina layer formation (GO:0010842)2.73828699
93regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73758084
94regulation of postsynaptic membrane potential (GO:0060078)2.73470982
95cerebral cortex radially oriented cell migration (GO:0021799)2.72188274
96positive regulation of membrane potential (GO:0045838)2.72021297
97negative regulation of astrocyte differentiation (GO:0048712)2.71968778
98negative regulation of dendrite development (GO:2000171)2.71359782
99cerebellum development (GO:0021549)2.70438789
100regulation of vesicle fusion (GO:0031338)2.69833358
101long-term memory (GO:0007616)2.69122330
102neuromuscular process controlling balance (GO:0050885)2.69011846
103cerebral cortex cell migration (GO:0021795)2.67877386
104cerebellar Purkinje cell layer development (GO:0021680)2.67470709
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67035222
106dendritic spine organization (GO:0097061)2.64853531
107camera-type eye morphogenesis (GO:0048593)2.64810976
108neurotransmitter transport (GO:0006836)2.64698669
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64607346
110regulation of respiratory gaseous exchange (GO:0043576)2.64471786
111cochlea development (GO:0090102)2.64072005
112behavioral defense response (GO:0002209)2.63020802
113behavioral fear response (GO:0001662)2.63020802
114tongue development (GO:0043586)2.62402171
115clathrin coat assembly (GO:0048268)2.60672509
116activation of protein kinase A activity (GO:0034199)2.60304416
117neuronal ion channel clustering (GO:0045161)2.58913386
118cranial nerve morphogenesis (GO:0021602)2.58694422
119response to pheromone (GO:0019236)2.57441837
120neuron migration (GO:0001764)2.56355755
121adult walking behavior (GO:0007628)2.54507636
122axon ensheathment in central nervous system (GO:0032291)2.53947519
123central nervous system myelination (GO:0022010)2.53947519
124glial cell proliferation (GO:0014009)2.53938825
125nonmotile primary cilium assembly (GO:0035058)2.51516155
126establishment of tissue polarity (GO:0007164)2.48893396
127establishment of planar polarity (GO:0001736)2.48893396
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.47724698
129apical protein localization (GO:0045176)2.47191820
130ephrin receptor signaling pathway (GO:0048013)2.46192476
131substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45838834
132substrate-independent telencephalic tangential migration (GO:0021826)2.45838834
133negative regulation of axon guidance (GO:1902668)2.43282456
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.42524926
135axon extension involved in axon guidance (GO:0048846)2.42524926
136otic vesicle formation (GO:0030916)2.41130843
137olfactory bulb development (GO:0021772)2.39315153
138membrane depolarization during action potential (GO:0086010)2.36320775
139regulation of axon extension (GO:0030516)2.35365435
140lens fiber cell development (GO:0070307)2.34353525
141neuromuscular synaptic transmission (GO:0007274)2.34058437
142axonogenesis (GO:0007409)2.33699690
143negative regulation of axon extension (GO:0030517)2.33210259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human5.61982912
2GBX2_23144817_ChIP-Seq_PC3_Human3.38400115
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06998668
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92398197
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.92230477
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85515892
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74181048
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74181048
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68193552
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65133134
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.62038170
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.60844613
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59821235
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54510736
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48099433
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46177462
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.38756601
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.35045337
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23690068
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22077502
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19735174
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16229868
23* CBX2_27304074_Chip-Seq_ESCs_Mouse2.03933506
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02613641
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00491793
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98751771
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94809347
28DROSHA_22980978_ChIP-Seq_HELA_Human1.92286916
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88941162
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.87641125
31* AR_21572438_ChIP-Seq_LNCaP_Human1.87233785
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85008669
33* ZNF274_21170338_ChIP-Seq_K562_Hela1.72260873
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.67376247
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.61099163
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60546982
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60228958
38RNF2_27304074_Chip-Seq_NSC_Mouse1.59833133
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58574039
40TAF15_26573619_Chip-Seq_HEK293_Human1.57937143
41* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55154573
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.54476165
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.51561304
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50738617
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49408276
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46389019
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.42294122
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39500077
49IGF1R_20145208_ChIP-Seq_DFB_Human1.36921176
50P300_19829295_ChIP-Seq_ESCs_Human1.36736832
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.35075210
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34749929
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33486892
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32213907
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.30891950
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.30061552
57FUS_26573619_Chip-Seq_HEK293_Human1.29136356
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27983711
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27171842
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26464521
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26464521
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25658619
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25247509
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24453536
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23469338
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.20858972
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20582335
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19461031
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19207483
70* AR_19668381_ChIP-Seq_PC3_Human1.15269395
71SOX9_26525672_Chip-Seq_HEART_Mouse1.14651582
72* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14109277
73* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11873150
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11274714
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11040938
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10620365
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10403348
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10288282
79* AR_25329375_ChIP-Seq_VCAP_Human1.10036640
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09745805
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09409814
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09296817
83* SMAD3_21741376_ChIP-Seq_ESCs_Human1.08727119
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08722694
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08620330
86* STAT3_23295773_ChIP-Seq_U87_Human1.08591957
87TP53_18474530_ChIP-ChIP_U2OS_Human1.07824891
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07238556
89* AHR_22903824_ChIP-Seq_MCF-7_Human1.06752611
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05093569
91* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04794829
92* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02762832
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02678966
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02330217
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01133566
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.00946483
97VDR_22108803_ChIP-Seq_LS180_Human0.99616198
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99467766
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98948807
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98127086
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97895562
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96610157
103P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96321605
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95836231
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.95245698
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.95179007
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94432216
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94399697
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93451579
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92879740
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91751808
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91505080
113* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91463729
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90762823
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90492044
116* TCF4_23295773_ChIP-Seq_U87_Human0.90460011
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90437768
118* KDM2B_26808549_Chip-Seq_REH_Human0.90201705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.03386250
2MP0003880_abnormal_central_pattern3.55872417
3MP0003635_abnormal_synaptic_transmissio3.04126151
4MP0000778_abnormal_nervous_system2.66635832
5MP0002063_abnormal_learning/memory/cond2.63584304
6MP0005423_abnormal_somatic_nervous2.58727917
7MP0004270_analgesia2.47461558
8MP0009745_abnormal_behavioral_response2.32912621
9MP0001486_abnormal_startle_reflex2.30044269
10MP0004858_abnormal_nervous_system2.23571134
11MP0002572_abnormal_emotion/affect_behav2.22742835
12MP0003122_maternal_imprinting2.17971719
13MP0006276_abnormal_autonomic_nervous2.13339229
14MP0001968_abnormal_touch/_nociception2.11949037
15MP0002184_abnormal_innervation2.11781026
16MP0002064_seizures2.11704210
17MP0009046_muscle_twitch2.03363669
18MP0002734_abnormal_mechanical_nocicepti1.99094770
19MP0002557_abnormal_social/conspecific_i1.94048488
20MP0001984_abnormal_olfaction1.82459680
21MP0002067_abnormal_sensory_capabilities1.76474807
22MP0002736_abnormal_nociception_after1.75177753
23MP0000631_abnormal_neuroendocrine_gland1.71066091
24MP0000569_abnormal_digit_pigmentation1.69603054
25MP0001502_abnormal_circadian_rhythm1.66722850
26MP0002733_abnormal_thermal_nociception1.61451980
27MP0001440_abnormal_grooming_behavior1.60340714
28MP0002272_abnormal_nervous_system1.60070096
29MP0002653_abnormal_ependyma_morphology1.59476074
30MP0001529_abnormal_vocalization1.59195421
31MP0003787_abnormal_imprinting1.58638184
32MP0009053_abnormal_anal_canal1.57330957
33MP0000955_abnormal_spinal_cord1.56334253
34MP0006072_abnormal_retinal_apoptosis1.55861938
35MP0002882_abnormal_neuron_morphology1.55646956
36MP0008789_abnormal_olfactory_epithelium1.55503282
37MP0005394_taste/olfaction_phenotype1.54974922
38MP0005499_abnormal_olfactory_system1.54974922
39MP0004811_abnormal_neuron_physiology1.48466784
40MP0002735_abnormal_chemical_nociception1.44042753
41MP0009780_abnormal_chondrocyte_physiolo1.43389971
42MP0005645_abnormal_hypothalamus_physiol1.43373422
43MP0002152_abnormal_brain_morphology1.41375166
44MP0005386_behavior/neurological_phenoty1.40026108
45MP0004924_abnormal_behavior1.40026108
46MP0005646_abnormal_pituitary_gland1.39395713
47MP0001970_abnormal_pain_threshold1.39009830
48MP0003879_abnormal_hair_cell1.37096837
49MP0003121_genomic_imprinting1.37073828
50MP0004133_heterotaxia1.35961342
51MP0001485_abnormal_pinna_reflex1.33221263
52MP0000579_abnormal_nail_morphology1.32970832
53MP0002909_abnormal_adrenal_gland1.32796731
54MP0005551_abnormal_eye_electrophysiolog1.32354486
55MP0001293_anophthalmia1.31857528
56MP0003861_abnormal_nervous_system1.29791359
57MP0001501_abnormal_sleep_pattern1.29716837
58MP0003937_abnormal_limbs/digits/tail_de1.27562061
59MP0001188_hyperpigmentation1.24757079
60* MP0003942_abnormal_urinary_system1.23892233
61MP0000534_abnormal_ureter_morphology1.21648807
62MP0002066_abnormal_motor_capabilities/c1.21602668
63MP0002752_abnormal_somatic_nervous1.19897334
64MP0000026_abnormal_inner_ear1.19894241
65MP0000762_abnormal_tongue_morphology1.18991825
66MP0005187_abnormal_penis_morphology1.15088978
67MP0005248_abnormal_Harderian_gland1.12948368
68MP0000049_abnormal_middle_ear1.12851561
69MP0002102_abnormal_ear_morphology1.12851200
70MP0008569_lethality_at_weaning1.12036417
71MP0006292_abnormal_olfactory_placode1.11899809
72MP0003136_yellow_coat_color1.08987506
73MP0002234_abnormal_pharynx_morphology1.05887908
74MP0004142_abnormal_muscle_tone1.05281182
75MP0004885_abnormal_endolymph1.04977425
76MP0003755_abnormal_palate_morphology1.04847378
77MP0003283_abnormal_digestive_organ1.04534435
78MP0004742_abnormal_vestibular_system1.04093897
79MP0005253_abnormal_eye_physiology1.03700710
80MP0000428_abnormal_craniofacial_morphol1.03118487
81MP0000751_myopathy1.02684893
82MP0003938_abnormal_ear_development1.02070909
83MP0010030_abnormal_orbit_morphology1.01927708
84MP0003329_amyloid_beta_deposits1.01695788
85MP0003123_paternal_imprinting1.01461601
86MP0002249_abnormal_larynx_morphology1.00943667
87MP0001286_abnormal_eye_development1.00245383
88MP0001963_abnormal_hearing_physiology0.99762618
89MP0003935_abnormal_craniofacial_develop0.99030910
90MP0002233_abnormal_nose_morphology0.98752054
91MP0005257_abnormal_intraocular_pressure0.97766211
92MP0002751_abnormal_autonomic_nervous0.97674797
93MP0001299_abnormal_eye_distance/0.97456682
94MP0002081_perinatal_lethality0.96508356
95MP0001905_abnormal_dopamine_level0.95725384
96MP0010368_abnormal_lymphatic_system0.94180778
97MP0009379_abnormal_foot_pigmentation0.92702831
98MP0005623_abnormal_meninges_morphology0.91328642
99MP0003119_abnormal_digestive_system0.91033974
100MP0003890_abnormal_embryonic-extraembry0.89741048
101MP0003634_abnormal_glial_cell0.88936989
102MP0000537_abnormal_urethra_morphology0.87728994
103MP0009250_abnormal_appendicular_skeleto0.87289232
104MP0001346_abnormal_lacrimal_gland0.87201216
105MP0000566_synostosis0.86785321
106MP0002822_catalepsy0.86699074
107MP0002116_abnormal_craniofacial_bone0.86192736
108MP0002177_abnormal_outer_ear0.85419552
109MP0003385_abnormal_body_wall0.85337101
110MP0001177_atelectasis0.82711992
111MP0002069_abnormal_eating/drinking_beha0.82610748
112MP0005195_abnormal_posterior_eye0.82589752
113MP0002697_abnormal_eye_size0.82218741
114MP0002938_white_spotting0.81985433
115MP0004233_abnormal_muscle_weight0.81117218
116MP0003941_abnormal_skin_development0.81069544

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.30196344
2Myokymia (HP:0002411)3.99226436
3Focal seizures (HP:0007359)3.67801201
4Progressive cerebellar ataxia (HP:0002073)3.36504310
5Visual hallucinations (HP:0002367)3.27373111
6Epileptic encephalopathy (HP:0200134)3.09039329
7Coronal craniosynostosis (HP:0004440)3.04072191
8Drooling (HP:0002307)2.94886208
9Excessive salivation (HP:0003781)2.94886208
10Febrile seizures (HP:0002373)2.82803857
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82767536
12Short 4th metacarpal (HP:0010044)2.82767536
13Absence seizures (HP:0002121)2.78463434
14Atonic seizures (HP:0010819)2.74839348
15Limb dystonia (HP:0002451)2.66822772
16Broad-based gait (HP:0002136)2.64200587
17True hermaphroditism (HP:0010459)2.62379262
18Megalencephaly (HP:0001355)2.60948036
19Pachygyria (HP:0001302)2.59628298
20Dialeptic seizures (HP:0011146)2.48503169
21Abnormality of the labia minora (HP:0012880)2.48392139
22Ankle clonus (HP:0011448)2.44733400
23Agitation (HP:0000713)2.39312183
24Amblyopia (HP:0000646)2.37573997
25Hyperventilation (HP:0002883)2.37216817
26Morphological abnormality of the middle ear (HP:0008609)2.31781363
27Optic nerve hypoplasia (HP:0000609)2.31625629
28Hemiparesis (HP:0001269)2.29056441
29Gait imbalance (HP:0002141)2.28743180
30Generalized tonic-clonic seizures (HP:0002069)2.28714980
31Truncal ataxia (HP:0002078)2.27973031
32Abnormality of the 4th metacarpal (HP:0010012)2.27946794
33Pancreatic fibrosis (HP:0100732)2.24367731
34Shawl scrotum (HP:0000049)2.23735574
35Progressive inability to walk (HP:0002505)2.22610225
36Action tremor (HP:0002345)2.21248289
37Supranuclear gaze palsy (HP:0000605)2.20669771
38Mutism (HP:0002300)2.20618263
39Shoulder girdle muscle weakness (HP:0003547)2.19951840
40Polyphagia (HP:0002591)2.19861440
41EEG with generalized epileptiform discharges (HP:0011198)2.17021791
42Epileptiform EEG discharges (HP:0011182)2.14626253
43High anterior hairline (HP:0009890)2.13836485
44Cutaneous finger syndactyly (HP:0010554)2.11684636
45Hypsarrhythmia (HP:0002521)2.10080928
46Neurofibrillary tangles (HP:0002185)2.08330988
47Specific learning disability (HP:0001328)2.07458116
48Nephronophthisis (HP:0000090)2.07263062
49Fetal akinesia sequence (HP:0001989)2.07185255
50Aplasia involving bones of the upper limbs (HP:0009823)2.06661037
51Aplasia of the phalanges of the hand (HP:0009802)2.06661037
52Aplasia involving bones of the extremities (HP:0009825)2.06661037
53Amyotrophic lateral sclerosis (HP:0007354)2.06078115
54Genetic anticipation (HP:0003743)2.04549456
55Dysdiadochokinesis (HP:0002075)2.03778666
56Failure to thrive in infancy (HP:0001531)2.03565894
57Cerebral inclusion bodies (HP:0100314)2.01821638
58Neonatal short-limb short stature (HP:0008921)2.01821438
59Rib fusion (HP:0000902)2.00780693
60Anophthalmia (HP:0000528)1.98423237
61Depression (HP:0000716)1.98405402
62Impaired vibration sensation in the lower limbs (HP:0002166)1.97418465
63Hepatoblastoma (HP:0002884)1.96675285
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95621126
65Sclerocornea (HP:0000647)1.95397463
66Bifid tongue (HP:0010297)1.93613381
67Abnormal hair whorl (HP:0010721)1.92142464
68Abnormality of salivation (HP:0100755)1.92082587
69Septo-optic dysplasia (HP:0100842)1.90171871
70Absent septum pellucidum (HP:0001331)1.90060505
71Genital tract atresia (HP:0001827)1.89597999
72Vaginal atresia (HP:0000148)1.89304881
73Hypoplasia of the brainstem (HP:0002365)1.88673999
74Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88673999
75Exotropia (HP:0000577)1.88010373
76Cortical dysplasia (HP:0002539)1.86417179
77Pendular nystagmus (HP:0012043)1.85133760
78Nuclear cataract (HP:0100018)1.84678767
79Retinal dysplasia (HP:0007973)1.84070362
80Lissencephaly (HP:0001339)1.83565671
81Abnormality of the diencephalon (HP:0010662)1.82054878
82Cutaneous syndactyly (HP:0012725)1.82041550
83Alacrima (HP:0000522)1.80795615
84Renal hypoplasia (HP:0000089)1.80114687
85Type II lissencephaly (HP:0007260)1.79942648
86Atrophic scars (HP:0001075)1.79443052
87Pancreatic cysts (HP:0001737)1.79113198
88Sacral dimple (HP:0000960)1.78474590
89Anencephaly (HP:0002323)1.77897195
90Congenital primary aphakia (HP:0007707)1.77776364
91Narrow nasal bridge (HP:0000446)1.77532413
92Anxiety (HP:0000739)1.77411983
93Abnormal eating behavior (HP:0100738)1.75251866
94Central scotoma (HP:0000603)1.73793340
95Aqueductal stenosis (HP:0002410)1.73657328
96Esophageal atresia (HP:0002032)1.73145986
97Insomnia (HP:0100785)1.72497043
98Pheochromocytoma (HP:0002666)1.71915457
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.68966970
100Abnormality of midbrain morphology (HP:0002418)1.68881653
101Molar tooth sign on MRI (HP:0002419)1.68881653
102Sleep apnea (HP:0010535)1.68214355
103Urinary bladder sphincter dysfunction (HP:0002839)1.67562392
104Abnormality of the lower motor neuron (HP:0002366)1.65970859
105Gaze-evoked nystagmus (HP:0000640)1.65673864
106Shallow orbits (HP:0000586)1.65270644
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.65036352
108Vitreoretinal degeneration (HP:0000655)1.64908781
109Urinary urgency (HP:0000012)1.64146975
110Abnormality of the aortic arch (HP:0012303)1.64141738
111Hypoventilation (HP:0002791)1.63796731
112Abnormality of the lacrimal duct (HP:0011481)1.63087231
113Absent speech (HP:0001344)1.62792170
114Autism (HP:0000717)1.62397133
115Abnormality of the corticospinal tract (HP:0002492)1.62224796
116Decreased lacrimation (HP:0000633)1.61479880
117Midline defect of the nose (HP:0004122)1.61170424
118Protruding tongue (HP:0010808)1.60810233
119Preaxial foot polydactyly (HP:0001841)1.60807917
120Abnormality of the antihelix (HP:0009738)1.60661532
121Postaxial hand polydactyly (HP:0001162)1.60586792
122Bilateral microphthalmos (HP:0007633)1.60561257
123Poor eye contact (HP:0000817)1.60533516
124Hypogonadotrophic hypogonadism (HP:0000044)1.60387686
125Spastic gait (HP:0002064)1.60088930
126Gastroesophageal reflux (HP:0002020)1.59961083
127Keratoconus (HP:0000563)1.59954512
128Increased corneal curvature (HP:0100692)1.59954512
129Termporal pattern (HP:0011008)1.59426881
130Insidious onset (HP:0003587)1.59426881
131Medial flaring of the eyebrow (HP:0010747)1.59290603
132Spastic tetraplegia (HP:0002510)1.59014506
133Impaired social interactions (HP:0000735)1.58179847
134Abnormal social behavior (HP:0012433)1.58179847
135Nephrogenic diabetes insipidus (HP:0009806)1.57981505
136Inability to walk (HP:0002540)1.57660104
137Renal duplication (HP:0000075)1.57463095
138Gastrointestinal atresia (HP:0002589)1.56918723
139Hemivertebrae (HP:0002937)1.56254318
140Narrow forehead (HP:0000341)1.56112043
141Abnormality of the renal medulla (HP:0100957)1.55970395
142Pointed chin (HP:0000307)1.55823185
143Scrotal hypoplasia (HP:0000046)1.55748843
144Hyperthyroidism (HP:0000836)1.55271013
145Tented upper lip vermilion (HP:0010804)1.54528036
146Postaxial foot polydactyly (HP:0001830)1.54523791
147Elfin facies (HP:0004428)1.53963554
148Micropenis (HP:0000054)1.53239989
149Trigonocephaly (HP:0000243)1.52732189
150Bronchomalacia (HP:0002780)1.51016153
151Missing ribs (HP:0000921)1.50854036
152Meningocele (HP:0002435)1.50321559
153Oligodactyly (HP:0012165)1.49832791
154Preaxial hand polydactyly (HP:0001177)1.49733328
155Abdominal situs inversus (HP:0003363)1.49541287
156Abnormality of abdominal situs (HP:0011620)1.49541287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.23870723
2NTRK23.40911106
3NTRK33.23988882
4CASK2.91656645
5MAP3K42.43972030
6MAP3K92.43782653
7MAPK132.40745459
8EPHA42.32249935
9MINK12.28358766
10PHKG22.06097727
11PHKG12.06097727
12PAK62.05090859
13MAP2K72.04091996
14LATS22.03325636
15KSR12.02724706
16TNIK1.86278429
17PRKD31.69732547
18ERBB31.64131815
19PINK11.61096298
20TYRO31.59236943
21UHMK11.59217404
22DYRK21.54494151
23SIK21.48673695
24PNCK1.39385120
25DAPK21.37292164
26NTRK11.36742212
27GRK71.28880313
28MAP2K41.28554631
29CDK51.28319258
30CSNK1G21.23230257
31PLK21.21262210
32CDK181.13412014
33KSR21.13200896
34DYRK1A1.11711050
35CDC71.10654959
36CDK151.09194702
37CDK141.04793770
38PAK31.02896842
39PRKCG0.99714643
40ERBB40.99532063
41EPHB20.97113337
42CDK11A0.95570223
43LMTK20.95473361
44DYRK1B0.94461700
45CSNK1G30.94016325
46BMPR1B0.92914697
47LATS10.90617599
48MAP3K120.90344834
49MOS0.88963341
50PRPF4B0.88502860
51CAMK2A0.88152524
52MAPK150.83630563
53SGK20.82474971
54GRK50.81804289
55BCR0.81670731
56TRIM280.80290699
57SGK2230.78740340
58SGK4940.78740340
59LIMK10.75458110
60CSNK1A1L0.73303692
61FER0.72072905
62STK380.71145155
63CAMKK10.70485467
64CAMK1G0.70369994
65ADRBK10.69472004
66ERBB20.69306629
67SIK30.69294673
68RPS6KA20.68708010
69ADRBK20.66832591
70STK110.66442205
71WNK30.66188887
72CSNK1G10.64935297
73FGFR20.64227414
74ICK0.62692409
75RET0.61459244
76WEE10.60889520
77MARK20.60595026
78DAPK10.60548761
79WNK40.60260070
80MKNK20.59791205
81NEK20.59546658
82PRKCZ0.59442636
83ARAF0.57800259
84FRK0.57531058
85TAF10.57219296
86CDC42BPA0.55398683
87MAP3K20.52402690
88SGK10.51229631
89DMPK0.51142770
90GRK10.50238013
91WNK10.49994408
92MAPK90.49544609
93NEK10.48657264
94CAMK2D0.48405532
95HIPK20.47588759
96RPS6KA30.47229101
97PRKCH0.46579529
98ROCK20.45856463
99PTK20.45811344
100CDK30.45492544
101PRKCE0.45267844
102PAK20.44890032
103SGK30.44745277
104CAMK2B0.44164893
105ROCK10.43995793
106STK38L0.42464653
107CSNK1E0.42149656
108AURKA0.42109482
109PRKD20.42061951
110FGR0.41408610
111BMPR20.40636200
112MAPK100.40604378
113NUAK10.39000130
114PKN10.38678183
115PDGFRA0.38609152
116MAP4K20.38240920
117INSRR0.38209361
118CAMK10.37752186
119CAMK2G0.36749930
120PRKDC0.36166036
121PLK30.35936613
122MAPK80.35817300
123BRSK10.35449156
124MKNK10.35227228
125DDR20.34620231
126GSK3B0.33230736
127CAMK40.32017845
128TAOK10.31839178
129CDK190.31388116
130CSNK1D0.30202928

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55945712
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75013080
3GABAergic synapse_Homo sapiens_hsa047272.59501550
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36291459
5Glutamatergic synapse_Homo sapiens_hsa047242.36235073
6Circadian entrainment_Homo sapiens_hsa047132.31145547
7Olfactory transduction_Homo sapiens_hsa047402.26561706
8Morphine addiction_Homo sapiens_hsa050322.15572889
9Dopaminergic synapse_Homo sapiens_hsa047282.04280327
10Amphetamine addiction_Homo sapiens_hsa050312.01656646
11Axon guidance_Homo sapiens_hsa043601.95743294
12Long-term potentiation_Homo sapiens_hsa047201.95663051
13Insulin secretion_Homo sapiens_hsa049111.88465802
14Cocaine addiction_Homo sapiens_hsa050301.86165531
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74300397
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73813024
17Cholinergic synapse_Homo sapiens_hsa047251.73485382
18Taste transduction_Homo sapiens_hsa047421.72892801
19Serotonergic synapse_Homo sapiens_hsa047261.70963543
20Phototransduction_Homo sapiens_hsa047441.64825992
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62362930
22Long-term depression_Homo sapiens_hsa047301.59814968
23Gap junction_Homo sapiens_hsa045401.54326416
24Renin secretion_Homo sapiens_hsa049241.53542137
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50818377
26Salivary secretion_Homo sapiens_hsa049701.46924749
27Gastric acid secretion_Homo sapiens_hsa049711.45204514
28Oxytocin signaling pathway_Homo sapiens_hsa049211.42287140
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42097833
30Steroid biosynthesis_Homo sapiens_hsa001001.41584345
31Melanogenesis_Homo sapiens_hsa049161.41025354
32GnRH signaling pathway_Homo sapiens_hsa049121.40626961
33Calcium signaling pathway_Homo sapiens_hsa040201.26142302
34Basal cell carcinoma_Homo sapiens_hsa052171.22726029
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21967748
36Endometrial cancer_Homo sapiens_hsa052131.20802457
37ErbB signaling pathway_Homo sapiens_hsa040121.20354060
38Estrogen signaling pathway_Homo sapiens_hsa049151.19462473
39Oocyte meiosis_Homo sapiens_hsa041141.17505097
40Hedgehog signaling pathway_Homo sapiens_hsa043401.16183162
41Glioma_Homo sapiens_hsa052141.15775570
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15007564
43Hippo signaling pathway_Homo sapiens_hsa043901.11396023
44Collecting duct acid secretion_Homo sapiens_hsa049661.10245724
45Wnt signaling pathway_Homo sapiens_hsa043101.08659421
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08176366
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08018218
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07298280
49Dorso-ventral axis formation_Homo sapiens_hsa043201.05680034
50Cardiac muscle contraction_Homo sapiens_hsa042601.05366029
51cAMP signaling pathway_Homo sapiens_hsa040241.00729901
52Type II diabetes mellitus_Homo sapiens_hsa049301.00446756
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99868615
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97709467
55Colorectal cancer_Homo sapiens_hsa052100.94871447
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94158932
57* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91039308
58ECM-receptor interaction_Homo sapiens_hsa045120.90064240
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86862405
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84237906
61Dilated cardiomyopathy_Homo sapiens_hsa054140.83100491
62Vibrio cholerae infection_Homo sapiens_hsa051100.82344251
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80963545
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78497587
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77577791
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77315478
67Alcoholism_Homo sapiens_hsa050340.76051432
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75526912
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73714753
70Circadian rhythm_Homo sapiens_hsa047100.73417401
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72666397
72Renal cell carcinoma_Homo sapiens_hsa052110.72666064
73mTOR signaling pathway_Homo sapiens_hsa041500.71231694
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.70439723
75MAPK signaling pathway_Homo sapiens_hsa040100.69623711
76Adherens junction_Homo sapiens_hsa045200.68710246
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.68646919
78Thyroid hormone synthesis_Homo sapiens_hsa049180.65854183
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65132687
80Ras signaling pathway_Homo sapiens_hsa040140.64440401
81MicroRNAs in cancer_Homo sapiens_hsa052060.63905523
82Choline metabolism in cancer_Homo sapiens_hsa052310.62579142
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.62034607
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61718633
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61292053
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61122283
87Vitamin B6 metabolism_Homo sapiens_hsa007500.60106016
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60038160
89Insulin signaling pathway_Homo sapiens_hsa049100.59733175
90Ovarian steroidogenesis_Homo sapiens_hsa049130.59333440
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58613015
92Glucagon signaling pathway_Homo sapiens_hsa049220.55892017
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55419004
94Notch signaling pathway_Homo sapiens_hsa043300.55183193
95Rap1 signaling pathway_Homo sapiens_hsa040150.54720798
96Prion diseases_Homo sapiens_hsa050200.54631001
97Melanoma_Homo sapiens_hsa052180.54308251
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53280771
99Focal adhesion_Homo sapiens_hsa045100.50677952
100Tight junction_Homo sapiens_hsa045300.50095271
101Non-small cell lung cancer_Homo sapiens_hsa052230.49520369
102Protein digestion and absorption_Homo sapiens_hsa049740.49278260
103VEGF signaling pathway_Homo sapiens_hsa043700.49109832
104Bile secretion_Homo sapiens_hsa049760.48825079
105Fanconi anemia pathway_Homo sapiens_hsa034600.48452014
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48038828
107Pathways in cancer_Homo sapiens_hsa052000.47119712
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45881601
109Bladder cancer_Homo sapiens_hsa052190.45858283
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45307324
111Butanoate metabolism_Homo sapiens_hsa006500.45200127
112Alzheimers disease_Homo sapiens_hsa050100.44944203
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44045687
114Prolactin signaling pathway_Homo sapiens_hsa049170.43258331
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43151992
116Selenocompound metabolism_Homo sapiens_hsa004500.42985077
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.42410113
118AMPK signaling pathway_Homo sapiens_hsa041520.40730320
119Pancreatic secretion_Homo sapiens_hsa049720.40436755
120Huntingtons disease_Homo sapiens_hsa050160.40417010
121Basal transcription factors_Homo sapiens_hsa030220.40261517
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39382549
123Ether lipid metabolism_Homo sapiens_hsa005650.36999324
124TGF-beta signaling pathway_Homo sapiens_hsa043500.36995667

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