CDH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)5.62900108
2axonal fasciculation (GO:0007413)5.22898730
3retinal ganglion cell axon guidance (GO:0031290)5.04649729
4lung epithelium development (GO:0060428)4.99473462
5negative regulation of axon extension involved in axon guidance (GO:0048843)4.94080509
6neuron projection extension involved in neuron projection guidance (GO:1902284)4.84537410
7axon extension involved in axon guidance (GO:0048846)4.84537410
8renal filtration (GO:0097205)4.74133276
9glomerular filtration (GO:0003094)4.70721957
10positive regulation of tolerance induction (GO:0002645)4.58989619
11glomerular epithelial cell development (GO:0072310)4.39583482
12dendritic spine morphogenesis (GO:0060997)4.31651266
13negative regulation of axon guidance (GO:1902668)4.31067635
14glomerular basement membrane development (GO:0032836)4.30650502
15establishment or maintenance of monopolar cell polarity (GO:0061339)4.10747819
16establishment of monopolar cell polarity (GO:0061162)4.10747819
17neuron recognition (GO:0008038)4.07667226
18neuronal ion channel clustering (GO:0045161)4.03046943
19establishment of apical/basal cell polarity (GO:0035089)4.01785749
20chondrocyte development (GO:0002063)4.01237823
21negative chemotaxis (GO:0050919)4.00353508
22neuron cell-cell adhesion (GO:0007158)3.99286391
23somite development (GO:0061053)3.93441158
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.88298077
25negative regulation of immunoglobulin mediated immune response (GO:0002890)3.85680294
26negative regulation of B cell mediated immunity (GO:0002713)3.85680294
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.79430283
28regulation of tolerance induction (GO:0002643)3.79217101
29regulation of axon extension involved in axon guidance (GO:0048841)3.70610811
30establishment of tissue polarity (GO:0007164)3.64060078
31establishment of planar polarity (GO:0001736)3.64060078
32negative regulation of T cell differentiation in thymus (GO:0033085)3.63502137
33regulation of axon guidance (GO:1902667)3.62410734
34presynaptic membrane organization (GO:0097090)3.59492238
35postsynaptic membrane organization (GO:0001941)3.55791524
36presynaptic membrane assembly (GO:0097105)3.53633595
37innervation (GO:0060384)3.50179415
38gamma-aminobutyric acid transport (GO:0015812)3.49036681
39regulation of chemokine-mediated signaling pathway (GO:0070099)3.47428081
40positive regulation of synapse assembly (GO:0051965)3.44951772
41atrial cardiac muscle cell action potential (GO:0086014)3.42052847
42regulation of hippo signaling (GO:0035330)3.39656980
43spinal cord development (GO:0021510)3.36641975
44nucleobase catabolic process (GO:0046113)3.35466037
45axon extension (GO:0048675)3.31922787
46cell migration in hindbrain (GO:0021535)3.31528237
47negative regulation of axon extension (GO:0030517)3.24110246
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.23777208
49kidney morphogenesis (GO:0060993)3.23675697
50positive regulation of cardiac muscle cell differentiation (GO:2000727)3.22434280
51regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16683605
52protein localization to synapse (GO:0035418)3.16496167
53appendage development (GO:0048736)3.15501631
54limb development (GO:0060173)3.15501631
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15030619
56cornea development in camera-type eye (GO:0061303)3.14605932
57behavioral response to nicotine (GO:0035095)3.14430435
58cranial nerve morphogenesis (GO:0021602)3.12839245
59response to pheromone (GO:0019236)3.11411712
60glycosphingolipid biosynthetic process (GO:0006688)3.11041346
61transmission of nerve impulse (GO:0019226)3.10477401
62cell proliferation involved in metanephros development (GO:0072203)3.08889940
63negative regulation of astrocyte differentiation (GO:0048712)3.08072478
64extracellular fibril organization (GO:0043206)3.05863667
65insulin-like growth factor receptor signaling pathway (GO:0048009)3.04698295
66cerebral cortex radially oriented cell migration (GO:0021799)3.04234692
67mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.02954634
68left/right pattern formation (GO:0060972)3.00301642
69motor neuron axon guidance (GO:0008045)2.98085495
70negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.98001069
71synaptic vesicle exocytosis (GO:0016079)2.97145811
72negative regulation of vascular permeability (GO:0043116)2.97059678
73dopaminergic neuron differentiation (GO:0071542)2.96172156
74nonmotile primary cilium assembly (GO:0035058)2.95435972
75regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.94644022
76limb bud formation (GO:0060174)2.93476315
77central nervous system projection neuron axonogenesis (GO:0021952)2.92786239
78vocalization behavior (GO:0071625)2.91863699
79stress granule assembly (GO:0034063)2.90987092
80layer formation in cerebral cortex (GO:0021819)2.90779221
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90629630
82negative regulation of axonogenesis (GO:0050771)2.89715213
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88659075
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86846619
85lateral sprouting from an epithelium (GO:0060601)2.86409116
86negative regulation of humoral immune response (GO:0002921)2.86264586
87collecting duct development (GO:0072044)2.85633830
88regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85592370
89sympathetic nervous system development (GO:0048485)2.85353412
90negative regulation of embryonic development (GO:0045992)2.85298917
91establishment of nucleus localization (GO:0040023)2.84458944
92hindbrain development (GO:0030902)2.84413354
93negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.84370270
94ganglion development (GO:0061548)2.82303752
95retina layer formation (GO:0010842)2.78998629
96neuron projection extension (GO:1990138)2.76534915
97glutamate secretion (GO:0014047)2.74927706
98protein polyglutamylation (GO:0018095)2.72970810
99branching involved in salivary gland morphogenesis (GO:0060445)2.72022582
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71582561
101regulation of axon extension (GO:0030516)2.71252096
102dendrite morphogenesis (GO:0048813)2.69102270
103heparan sulfate proteoglycan metabolic process (GO:0030201)2.68697299
104negative regulation of leukocyte chemotaxis (GO:0002689)2.67726771
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67259702
106regulation of synapse assembly (GO:0051963)2.67247594
107mesenchyme morphogenesis (GO:0072132)2.66632909
108pyrimidine nucleobase catabolic process (GO:0006208)2.66430407
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66123576
110dendritic spine organization (GO:0097061)2.65354648
111paraxial mesoderm development (GO:0048339)2.65020445
112* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.64344940
113epithelial cilium movement (GO:0003351)2.63940852
114apical protein localization (GO:0045176)2.63658291
115regulation of collateral sprouting (GO:0048670)2.63495021
116olfactory bulb development (GO:0021772)2.62499999
117cell proliferation in forebrain (GO:0021846)2.62282154
118calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59418172
119startle response (GO:0001964)2.58229918
120synaptic transmission, glutamatergic (GO:0035249)2.57196093
121artery development (GO:0060840)2.54276760
122histamine secretion (GO:0001821)2.53808648
123camera-type eye morphogenesis (GO:0048593)2.53464395
124thalamus development (GO:0021794)2.53320006
125regulation of synaptic vesicle exocytosis (GO:2000300)2.52833896
126tolerance induction (GO:0002507)2.52023574
127regulation of mesenchymal cell apoptotic process (GO:2001053)2.51248489
128urogenital system development (GO:0001655)2.51070616
129regulation of dendritic spine morphogenesis (GO:0061001)2.50995289
130synapse organization (GO:0050808)2.50919521
131dendrite development (GO:0016358)2.50901459
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50398634
133cerebral cortex cell migration (GO:0021795)2.49701788
134anatomical structure arrangement (GO:0048532)2.49540190
135glomerulus development (GO:0032835)2.48998691
136regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.48890449
137synapse assembly (GO:0007416)2.48840545
138central nervous system neuron axonogenesis (GO:0021955)2.46798911
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45624571
140neuronal stem cell maintenance (GO:0097150)2.44714331
141negative regulation of dendrite development (GO:2000171)2.43605757
142regulation of mesoderm development (GO:2000380)2.42516493
143dentate gyrus development (GO:0021542)2.42207099
144intraciliary transport (GO:0042073)2.36267588
145behavioral response to ethanol (GO:0048149)2.35328398
146neural tube formation (GO:0001841)2.34461703
147positive regulation of dendritic spine morphogenesis (GO:0061003)2.34010279
148inner ear receptor cell development (GO:0060119)2.33392212
149positive regulation of male gonad development (GO:2000020)2.33308389
150chondrocyte proliferation (GO:0035988)2.31717859
151forebrain neuron differentiation (GO:0021879)2.28990888
152smoothened signaling pathway (GO:0007224)2.28434164
153dorsal/ventral pattern formation (GO:0009953)2.27469601
154pituitary gland development (GO:0021983)2.27245933
155negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26728514
156neuron fate determination (GO:0048664)2.25451871
157negative regulation of glial cell differentiation (GO:0045686)2.24797603
158arginine catabolic process (GO:0006527)2.24615989
159ephrin receptor signaling pathway (GO:0048013)2.24374707
160cilium organization (GO:0044782)2.23555226
161cilium assembly (GO:0042384)2.20748616
162neural crest cell development (GO:0014032)2.20667203
163otic vesicle formation (GO:0030916)2.19969020
164negative regulation of DNA binding (GO:0043392)2.19471862
165negative regulation of chemotaxis (GO:0050922)2.19232819
166ovulation cycle (GO:0042698)2.18477119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40407356
2GBX2_23144817_ChIP-Seq_PC3_Human3.49706338
3TAF15_26573619_Chip-Seq_HEK293_Human3.22634535
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97222026
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.94058270
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90355213
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81926033
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79616270
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77030412
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77030412
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.73818995
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69916765
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.64891105
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57569478
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49408272
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46478866
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34195446
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.30409804
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22569986
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18605817
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.17105245
22VDR_22108803_ChIP-Seq_LS180_Human2.11088382
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10269906
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01865335
25* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95692196
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94057839
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.91722318
28* P300_19829295_ChIP-Seq_ESCs_Human1.88484794
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83423572
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83156257
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82634981
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.77738559
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.74432449
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73791277
35FUS_26573619_Chip-Seq_HEK293_Human1.72502039
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72229069
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70524491
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.68791096
39ZNF274_21170338_ChIP-Seq_K562_Hela1.66995449
40* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66227304
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66037150
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63905313
43DROSHA_22980978_ChIP-Seq_HELA_Human1.63763764
44* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57673317
45* ARNT_22903824_ChIP-Seq_MCF-7_Human1.57625002
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56626601
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56202223
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55309258
49SMAD4_21799915_ChIP-Seq_A2780_Human1.55233071
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54304783
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.54081145
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.52230203
53BCAT_22108803_ChIP-Seq_LS180_Human1.50369194
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.49729130
55* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47479667
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43883356
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43849599
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43658128
59AR_21572438_ChIP-Seq_LNCaP_Human1.43179004
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42629152
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40620429
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40424688
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36964326
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.36660668
65* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35505851
66* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35265772
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.35058301
68SOX9_26525672_Chip-Seq_HEART_Mouse1.34788351
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34157125
70TP53_16413492_ChIP-PET_HCT116_Human1.33218722
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32553408
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.31896098
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31717050
74* AHR_22903824_ChIP-Seq_MCF-7_Human1.31486483
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30431081
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30338373
77* EWS_26573619_Chip-Seq_HEK293_Human1.29947468
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28783187
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.28688256
80* REST_21632747_ChIP-Seq_MESCs_Mouse1.27897796
81* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27200853
82CBP_20019798_ChIP-Seq_JUKART_Human1.26422915
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26422915
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.26362311
85* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25973806
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24624460
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24235272
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.23679113
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23400015
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23105393
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21871534
92TCF4_23295773_ChIP-Seq_U87_Human1.20447926
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17159338
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.14865900
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.14766563
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14297287
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13233695
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12486732
99RNF2_27304074_Chip-Seq_NSC_Mouse1.10171491
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09013327
101RUNX2_22187159_ChIP-Seq_PCA_Human1.09012788
102AR_19668381_ChIP-Seq_PC3_Human1.08934405
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08809167
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07598320
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07516612
106SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06217831
107IRF1_19129219_ChIP-ChIP_H3396_Human1.06038190
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.05604332
109TP53_18474530_ChIP-ChIP_U2OS_Human1.05546085
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05285600
111* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04372969
112* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03992221
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03864549
114* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03604763
115IGF1R_20145208_ChIP-Seq_DFB_Human1.03091900
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02538748
117* STAT3_23295773_ChIP-Seq_U87_Human1.02465801
118AR_25329375_ChIP-Seq_VCAP_Human1.02454549
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01340969
120* JUN_21703547_ChIP-Seq_K562_Human1.01281594
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01107044
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01060732
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00642796
124ER_23166858_ChIP-Seq_MCF-7_Human0.98588781
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98115072
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98115072
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97180075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.33480486
2MP0003880_abnormal_central_pattern2.73772085
3MP0004270_analgesia2.62581344
4MP0006292_abnormal_olfactory_placode2.61445897
5MP0000778_abnormal_nervous_system2.59727021
6MP0004859_abnormal_synaptic_plasticity2.58042493
7MP0000534_abnormal_ureter_morphology2.54098053
8MP0002751_abnormal_autonomic_nervous2.50979314
9* MP0003942_abnormal_urinary_system2.48762437
10MP0004272_abnormal_basement_membrane2.45401142
11MP0003122_maternal_imprinting2.35747508
12MP0001299_abnormal_eye_distance/2.32471277
13MP0002184_abnormal_innervation2.20601253
14MP0003635_abnormal_synaptic_transmissio2.07894915
15MP0009053_abnormal_anal_canal2.06368485
16MP0005623_abnormal_meninges_morphology2.03865836
17MP0009384_cardiac_valve_regurgitation2.01253622
18MP0008789_abnormal_olfactory_epithelium1.80052850
19MP0005171_absent_coat_pigmentation1.78880925
20MP0004133_heterotaxia1.74396892
21MP0002653_abnormal_ependyma_morphology1.70174602
22MP0001984_abnormal_olfaction1.67564711
23MP0004885_abnormal_endolymph1.67114943
24MP0005367_renal/urinary_system_phenotyp1.65415449
25MP0000516_abnormal_urinary_system1.65415449
26MP0000955_abnormal_spinal_cord1.62334452
27MP0000462_abnormal_digestive_system1.61685878
28MP0002063_abnormal_learning/memory/cond1.60071550
29MP0001529_abnormal_vocalization1.55367746
30MP0005248_abnormal_Harderian_gland1.55236614
31MP0004233_abnormal_muscle_weight1.53638585
32MP0004084_abnormal_cardiac_muscle1.53186469
33MP0002734_abnormal_mechanical_nocicepti1.53020617
34MP0000467_abnormal_esophagus_morphology1.51319582
35MP0002938_white_spotting1.48199405
36MP0005187_abnormal_penis_morphology1.47957436
37MP0002249_abnormal_larynx_morphology1.47701362
38MP0002638_abnormal_pupillary_reflex1.46252329
39MP0005551_abnormal_eye_electrophysiolog1.45695917
40MP0001968_abnormal_touch/_nociception1.44877966
41MP0002064_seizures1.42818914
42MP0009745_abnormal_behavioral_response1.40856451
43MP0003385_abnormal_body_wall1.39505150
44MP0005499_abnormal_olfactory_system1.37673458
45MP0005394_taste/olfaction_phenotype1.37673458
46MP0002282_abnormal_trachea_morphology1.37346079
47MP0004742_abnormal_vestibular_system1.36201249
48MP0003634_abnormal_glial_cell1.34122136
49MP0002572_abnormal_emotion/affect_behav1.33683718
50MP0002928_abnormal_bile_duct1.33298584
51MP0002102_abnormal_ear_morphology1.32396335
52MP0003755_abnormal_palate_morphology1.31718068
53MP0003787_abnormal_imprinting1.31059957
54MP0003861_abnormal_nervous_system1.30833868
55MP0001286_abnormal_eye_development1.30605783
56MP0003937_abnormal_limbs/digits/tail_de1.28028872
57MP0003938_abnormal_ear_development1.27623170
58MP0003283_abnormal_digestive_organ1.27527206
59MP0000569_abnormal_digit_pigmentation1.27418997
60MP0003115_abnormal_respiratory_system1.26535105
61MP0002882_abnormal_neuron_morphology1.25903792
62MP0001188_hyperpigmentation1.25440696
63MP0009046_muscle_twitch1.24817933
64MP0009250_abnormal_appendicular_skeleto1.24343229
65MP0006072_abnormal_retinal_apoptosis1.23482051
66MP0004858_abnormal_nervous_system1.21075011
67MP0002837_dystrophic_cardiac_calcinosis1.20952756
68MP0002234_abnormal_pharynx_morphology1.19980800
69MP0000049_abnormal_middle_ear1.16346387
70MP0005195_abnormal_posterior_eye1.15522832
71MP0002152_abnormal_brain_morphology1.15245714
72MP0008877_abnormal_DNA_methylation1.14181082
73MP0000428_abnormal_craniofacial_morphol1.13983693
74MP0002067_abnormal_sensory_capabilities1.12910915
75MP0004142_abnormal_muscle_tone1.12851146
76MP0004811_abnormal_neuron_physiology1.12684036
77MP0000566_synostosis1.12280313
78MP0001293_anophthalmia1.11968605
79MP0000631_abnormal_neuroendocrine_gland1.11510222
80MP0002932_abnormal_joint_morphology1.11403987
81MP0005253_abnormal_eye_physiology1.10035659
82MP0002272_abnormal_nervous_system1.09775340
83MP0002116_abnormal_craniofacial_bone1.09574412
84MP0000751_myopathy1.09420447
85MP0000749_muscle_degeneration1.09327587
86MP0004134_abnormal_chest_morphology1.07518143
87MP0002736_abnormal_nociception_after1.07116726
88MP0003632_abnormal_nervous_system1.06197242
89MP0002092_abnormal_eye_morphology1.05236043
90MP0005646_abnormal_pituitary_gland1.03729821
91MP0001177_atelectasis1.02857702
92MP0002735_abnormal_chemical_nociception1.02780711
93MP0005084_abnormal_gallbladder_morpholo1.02706377
94MP0003136_yellow_coat_color1.02344061
95MP0009780_abnormal_chondrocyte_physiolo1.02116207
96MP0001485_abnormal_pinna_reflex1.01864183
97MP0002557_abnormal_social/conspecific_i1.00882261
98MP0001486_abnormal_startle_reflex1.00805617
99MP0003137_abnormal_impulse_conducting0.99991883
100MP0002752_abnormal_somatic_nervous0.99782111
101MP0003121_genomic_imprinting0.99632875
102MP0002233_abnormal_nose_morphology0.99436711
103MP0004145_abnormal_muscle_electrophysio0.98872538
104MP0002822_catalepsy0.94471040
105MP0002697_abnormal_eye_size0.94075277
106MP0002876_abnormal_thyroid_physiology0.93691367
107MP0001963_abnormal_hearing_physiology0.93663953
108MP0001970_abnormal_pain_threshold0.92348089
109MP0010030_abnormal_orbit_morphology0.92175460
110MP0003935_abnormal_craniofacial_develop0.91192630
111MP0005423_abnormal_somatic_nervous0.90309235
112MP0000579_abnormal_nail_morphology0.90144738
113MP0003878_abnormal_ear_physiology0.89603088
114MP0005377_hearing/vestibular/ear_phenot0.89603088
115MP0002081_perinatal_lethality0.89584890
116MP0006276_abnormal_autonomic_nervous0.89213199
117MP0000026_abnormal_inner_ear0.89200231
118MP0001879_abnormal_lymphatic_vessel0.88218322
119MP0005386_behavior/neurological_phenoty0.87737863
120MP0004924_abnormal_behavior0.87737863
121MP0005391_vision/eye_phenotype0.87339379
122MP0003011_delayed_dark_adaptation0.86508760
123MP0005503_abnormal_tendon_morphology0.86232145
124MP0002160_abnormal_reproductive_system0.85596393
125MP0000920_abnormal_myelination0.85025940
126MP0002733_abnormal_thermal_nociception0.85024199
127MP0003315_abnormal_perineum_morphology0.84492814
128MP0002111_abnormal_tail_morphology0.84353704
129MP0001943_abnormal_respiration0.84113574
130MP0006138_congestive_heart_failure0.83298643
131MP0003119_abnormal_digestive_system0.81777762
132MP0001324_abnormal_eye_pigmentation0.81579006
133MP0003890_abnormal_embryonic-extraembry0.80431754
134MP0002168_other_aberrant_phenotype0.80328477

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the ischium (HP:0003174)3.52072151
2Hypoplastic ischia (HP:0003175)3.48223873
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32412619
4Short 4th metacarpal (HP:0010044)3.32412619
5Abnormality of the labia minora (HP:0012880)3.31330645
6Pancreatic fibrosis (HP:0100732)3.20188896
7Focal motor seizures (HP:0011153)3.11235011
8Pancreatic cysts (HP:0001737)3.08032974
9Nephronophthisis (HP:0000090)3.04145906
10True hermaphroditism (HP:0010459)3.01415556
11Abnormality of midbrain morphology (HP:0002418)2.81606970
12Molar tooth sign on MRI (HP:0002419)2.81606970
13Abnormality of the renal medulla (HP:0100957)2.75652731
14Wrist flexion contracture (HP:0001239)2.75570403
15Diaphragmatic weakness (HP:0009113)2.75459991
16Abnormality of the phalanges of the 2nd finger (HP:0009541)2.69045575
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.64430259
18Termporal pattern (HP:0011008)2.62649128
19Insidious onset (HP:0003587)2.62649128
20Short hallux (HP:0010109)2.60115823
21Aplasia/Hypoplasia of the hallux (HP:0008362)2.53275898
22Exotropia (HP:0000577)2.53119608
23Epileptic encephalopathy (HP:0200134)2.51606984
24Optic nerve hypoplasia (HP:0000609)2.49138353
25Stenosis of the external auditory canal (HP:0000402)2.48994987
26Mesangial abnormality (HP:0001966)2.48920051
27Focal seizures (HP:0007359)2.45488015
28Abnormal pancreas size (HP:0012094)2.44723929
29Myokymia (HP:0002411)2.43933680
30Increased corneal curvature (HP:0100692)2.41721340
31Keratoconus (HP:0000563)2.41721340
32Ankyloglossia (HP:0010296)2.41485285
33Chronic hepatic failure (HP:0100626)2.39722716
34Medial flaring of the eyebrow (HP:0010747)2.37649039
35Hemiparesis (HP:0001269)2.34193854
36Small epiphyses (HP:0010585)2.33256847
37Abnormality of the 4th metacarpal (HP:0010012)2.32010874
38Preaxial foot polydactyly (HP:0001841)2.32006854
39Spinal muscular atrophy (HP:0007269)2.27653546
40Growth hormone deficiency (HP:0000824)2.26930456
41Alacrima (HP:0000522)2.26018695
42Chorioretinal atrophy (HP:0000533)2.24563191
43Abnormality of oral frenula (HP:0000190)2.21681266
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21082416
45Stridor (HP:0010307)2.20857256
46Postaxial hand polydactyly (HP:0001162)2.19952173
47Midline defect of the nose (HP:0004122)2.19927782
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.19467757
49Septo-optic dysplasia (HP:0100842)2.16238891
50Narrow nasal bridge (HP:0000446)2.15792920
51Renal hypoplasia (HP:0000089)2.14717940
52Abnormality of the middle phalanges of the toes (HP:0010183)2.14129069
53Short tibia (HP:0005736)2.08612091
54Fair hair (HP:0002286)2.08473687
55Myelomeningocele (HP:0002475)2.08141209
56Febrile seizures (HP:0002373)2.07820261
57Neonatal short-limb short stature (HP:0008921)2.07465485
58Hyperventilation (HP:0002883)2.06947343
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.06381820
60Focal segmental glomerulosclerosis (HP:0000097)2.05540652
61Abnormality of the lower motor neuron (HP:0002366)2.05299728
62Cystic liver disease (HP:0006706)2.03750877
63Abnormality of the proximal phalanges of the hand (HP:0009834)2.02696363
64Epiphyseal dysplasia (HP:0002656)2.01067919
65Heterochromia iridis (HP:0001100)2.00292865
66Decreased lacrimation (HP:0000633)1.99868911
67Buphthalmos (HP:0000557)1.99213784
68Intestinal atresia (HP:0011100)1.98711531
69Hypoventilation (HP:0002791)1.98195263
70Degeneration of anterior horn cells (HP:0002398)1.98130258
71Abnormality of the anterior horn cell (HP:0006802)1.98130258
72Congenital primary aphakia (HP:0007707)1.97995067
73Megalencephaly (HP:0001355)1.97514178
74Congenital stationary night blindness (HP:0007642)1.97439683
75Amblyopia (HP:0000646)1.97042685
76Sclerocornea (HP:0000647)1.94555893
77Aqueductal stenosis (HP:0002410)1.93571156
78Blue irides (HP:0000635)1.92832840
79Arthropathy (HP:0003040)1.92593243
80Broad metatarsal (HP:0001783)1.92531687
81Rib fusion (HP:0000902)1.92395331
82Bilateral microphthalmos (HP:0007633)1.91343412
83Shallow orbits (HP:0000586)1.91296455
84Drooling (HP:0002307)1.91209835
85Excessive salivation (HP:0003781)1.91209835
86Anencephaly (HP:0002323)1.91182025
87Type II lissencephaly (HP:0007260)1.90593594
88Gastrointestinal atresia (HP:0002589)1.90246489
89High anterior hairline (HP:0009890)1.90222989
90Increased number of teeth (HP:0011069)1.90141744
91Maternal diabetes (HP:0009800)1.90094021
92Anophthalmia (HP:0000528)1.90088858
93Fibular hypoplasia (HP:0003038)1.89709554
94Abnormality of the renal cortex (HP:0011035)1.89154880
95Abnormality of the corticospinal tract (HP:0002492)1.88434562
96Ulnar deviation of finger (HP:0009465)1.88245239
97Synostosis of carpal bones (HP:0005048)1.88157037
98Truncus arteriosus (HP:0001660)1.88099477
99Hepatoblastoma (HP:0002884)1.86560419
100Hypoplasia of the ulna (HP:0003022)1.85498489
101Thyroid-stimulating hormone excess (HP:0002925)1.85258676
102Narrow forehead (HP:0000341)1.84537909
103Abnormality of the phalanges of the 5th finger (HP:0004213)1.83560937
104Absent speech (HP:0001344)1.83178320
105Atonic seizures (HP:0010819)1.83008681
106Abnormal number of incisors (HP:0011064)1.81998234
107Abnormality of the pubic bones (HP:0003172)1.80948611
108Cutaneous finger syndactyly (HP:0010554)1.80723478
109Postaxial foot polydactyly (HP:0001830)1.80601839
110Hypoplastic pelvis (HP:0008839)1.80097233
111Oligodactyly (hands) (HP:0001180)1.79755296
112Progressive cerebellar ataxia (HP:0002073)1.79703506
113Nephrogenic diabetes insipidus (HP:0009806)1.78667991
114Abolished electroretinogram (ERG) (HP:0000550)1.78392745
115Neoplasm of the adrenal cortex (HP:0100641)1.78339397
116Broad hallux (HP:0010055)1.77648914
117Intellectual disability, moderate (HP:0002342)1.77522561
118Cutaneous syndactyly (HP:0012725)1.77475569
119Broad-based gait (HP:0002136)1.76719896
120Shawl scrotum (HP:0000049)1.76355193
121Scanning speech (HP:0002168)1.74699635
122Abnormality of incisor morphology (HP:0011063)1.74568105
123Aplasia cutis congenita (HP:0001057)1.74235348
124Arterial tortuosity (HP:0005116)1.73943498
125Small hand (HP:0200055)1.73165472
126Preaxial hand polydactyly (HP:0001177)1.71779311
127Vitreoretinal degeneration (HP:0000655)1.71342227
128Limb dystonia (HP:0002451)1.71132365
129Delayed gross motor development (HP:0002194)1.71092233
130Broad toe (HP:0001837)1.70705903
131Humeroradial synostosis (HP:0003041)1.70317256
132Synostosis involving the elbow (HP:0003938)1.70317256
133Bifid scrotum (HP:0000048)1.69651713
134Absent septum pellucidum (HP:0001331)1.69603752
135Hammertoe (HP:0001765)1.68938646
136Aplasia/Hypoplasia of the fibula (HP:0006492)1.68808617
137Aortic aneurysm (HP:0004942)1.67784245
138Open mouth (HP:0000194)1.66765718
139Specific learning disability (HP:0001328)1.66146855
140Anterior segment dysgenesis (HP:0007700)1.65306084
141Short foot (HP:0001773)1.64710773
142Renal dysplasia (HP:0000110)1.64563004
143Ankle clonus (HP:0011448)1.64348555
144Polyphagia (HP:0002591)1.64345214
145Glomerulosclerosis (HP:0000096)1.64127497
146Ulnar claw (HP:0001178)1.63658385
147Tubular atrophy (HP:0000092)1.63467535
148Bowel incontinence (HP:0002607)1.62794207
149Genetic anticipation (HP:0003743)1.62777108
150Coronal craniosynostosis (HP:0004440)1.62618926
151Partial agenesis of the corpus callosum (HP:0001338)1.62158793
152Lissencephaly (HP:0001339)1.61272149
153Vaginal atresia (HP:0000148)1.60577074
154Action tremor (HP:0002345)1.60450956
155Genital tract atresia (HP:0001827)1.59165189
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58916100
157Vascular tortuosity (HP:0004948)1.57212114
158Absent eyebrow (HP:0002223)1.57050080
159Morphological abnormality of the middle ear (HP:0008609)1.56959573
160Patellar dislocation (HP:0002999)1.56703688
161Labial hypoplasia (HP:0000066)1.55863973
162Carpal bone hypoplasia (HP:0001498)1.55363044
163Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.53930798
164Generalized hypopigmentation of hair (HP:0011358)1.53867290
165Degeneration of the lateral corticospinal tracts (HP:0002314)1.53083605
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.53083605
167Hyperthyroidism (HP:0000836)1.52746272
168Short metatarsal (HP:0010743)1.52084954
169Shoulder girdle muscle weakness (HP:0003547)1.51556057
170Atrophy/Degeneration involving motor neurons (HP:0007373)1.49628847
171Bicornuate uterus (HP:0000813)1.49445990
172Abnormality of the incisor (HP:0000676)1.49185309
173Oligodactyly (HP:0012165)1.49001043
174Broad thumb (HP:0011304)1.48898371
175Gait imbalance (HP:0002141)1.47053836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.30015035
2NTRK15.14796398
3KSR15.05347636
4FRK4.27611341
5BCR4.11613011
6EPHB23.61048238
7NTRK23.39804732
8WNK33.26321013
9CASK3.18358577
10MARK12.81789917
11EIF2AK32.56930837
12MINK12.37924906
13MAP4K22.24977143
14PINK12.09617671
15ADRBK21.90736550
16BMPR1B1.89715097
17ERBB21.73595759
18TIE11.69548230
19MAP3K91.63422631
20EPHA41.58948076
21NTRK31.52656956
22TRIM281.52312409
23PLK21.52309641
24GRK11.48584824
25MKNK21.37110728
26MAP3K41.35247908
27CDK191.28160751
28STK38L1.24119098
29SIK11.21106022
30NUAK11.19400281
31WNK41.18600631
32CDK181.13913532
33FGFR21.12075543
34DAPK21.09776133
35CSNK1G31.03588423
36CSNK1A1L1.01479115
37LIMK10.97414719
38PAK30.96958861
39CSNK1G20.95561905
40MAP3K120.94972161
41MET0.94874201
42IRAK20.94739804
43DDR20.94080869
44UHMK10.94006457
45ZAK0.93523998
46TNIK0.90783452
47TYRO30.90259490
48OXSR10.90220139
49MAPK130.88286180
50CCNB10.84685026
51TTN0.84357862
52INSRR0.83139156
53CDK140.80967827
54DYRK1A0.79983658
55DAPK10.79304560
56CDK50.77929075
57WEE10.76801012
58CDK150.76676241
59PTK20.76566447
60ERBB30.76556440
61PNCK0.76524183
62FER0.74315735
63ICK0.74063128
64DYRK30.73647283
65ADRBK10.73434957
66CSNK1G10.71675334
67SGK4940.70794976
68SGK2230.70794976
69MATK0.70782112
70PTK2B0.69883104
71MAP2K70.67466329
72LATS20.67280388
73CAMK2A0.63858238
74FGFR10.63508548
75ROCK20.63072138
76PAK60.62760053
77STK30.62743789
78CDK11A0.62283459
79PRKCE0.62201878
80PIK3CA0.62101517
81CAMK1G0.60915574
82PAK20.59755108
83NEK90.59547114
84PDGFRA0.56852755
85PAK40.56640743
86CAMK2B0.55409563
87MAPK150.54908202
88CAMK1D0.54627889
89TLK10.54098805
90SRC0.53770435
91ROCK10.49129021
92PRKCG0.47017577
93MKNK10.46096568
94TGFBR10.45713943
95DYRK20.45225912
96DMPK0.44626843
97PRKG10.44363520
98KSR20.44198725
99FYN0.44173002
100PRKACA0.43351279
101SGK20.43003342
102MTOR0.42972539
103LATS10.42525897
104PLK30.41054259
105CDK30.39862131
106EGFR0.38714584
107GRK50.38476429
108MAP2K10.38430046
109ERBB40.37494916
110CAMK10.37370590
111CSNK1D0.36741985
112PHKG20.34822407
113PHKG10.34822407
114DAPK30.33381870
115SIK20.32375601
116STK110.32167389
117INSR0.31926984
118CAMK2D0.31014657
119PRKCZ0.30523102
120MAP2K40.30361846
121PRKD30.29987833
122TAF10.29898257
123PBK0.29671854
124EPHA20.29644275
125STK390.28911781
126PRKDC0.28310796
127CSNK1A10.27866909
128NEK10.27782319
129PLK10.27320402
130PKN10.26813389
131MYLK0.26467534
132CDC42BPA0.26283781
133AKT30.26001766
134SGK10.24995319
135RET0.24365065
136PRKCI0.24089408
137CAMKK20.22833157
138MAP3K100.22823674
139CSNK1E0.22779614

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.83663812
2Axon guidance_Homo sapiens_hsa043602.81617258
3Basal cell carcinoma_Homo sapiens_hsa052172.60449887
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.52514271
5Nicotine addiction_Homo sapiens_hsa050332.49306093
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34762161
7Hedgehog signaling pathway_Homo sapiens_hsa043402.26523820
8Protein export_Homo sapiens_hsa030602.21509888
9Synaptic vesicle cycle_Homo sapiens_hsa047212.19778722
10Nitrogen metabolism_Homo sapiens_hsa009102.11790257
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09647105
12Hippo signaling pathway_Homo sapiens_hsa043901.99966439
13ErbB signaling pathway_Homo sapiens_hsa040121.84250320
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84083801
15Glioma_Homo sapiens_hsa052141.79379040
16Melanogenesis_Homo sapiens_hsa049161.75170886
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74392160
18Circadian entrainment_Homo sapiens_hsa047131.73207261
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.66460377
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62098390
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58558123
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57556189
23Dilated cardiomyopathy_Homo sapiens_hsa054141.54325534
24Long-term potentiation_Homo sapiens_hsa047201.52445665
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52103908
26Amphetamine addiction_Homo sapiens_hsa050311.51798065
27Gap junction_Homo sapiens_hsa045401.51701603
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47032664
29Wnt signaling pathway_Homo sapiens_hsa043101.45504476
30Dopaminergic synapse_Homo sapiens_hsa047281.44456255
31GABAergic synapse_Homo sapiens_hsa047271.41985037
32ECM-receptor interaction_Homo sapiens_hsa045121.39522228
33Long-term depression_Homo sapiens_hsa047301.38277852
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38274785
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38140126
36Morphine addiction_Homo sapiens_hsa050321.37869024
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36072568
38Focal adhesion_Homo sapiens_hsa045101.31396087
39Cocaine addiction_Homo sapiens_hsa050301.31340970
40Glutamatergic synapse_Homo sapiens_hsa047241.31228440
41Adherens junction_Homo sapiens_hsa045201.30655138
42Renal cell carcinoma_Homo sapiens_hsa052111.30579004
43Cholinergic synapse_Homo sapiens_hsa047251.28736829
44Collecting duct acid secretion_Homo sapiens_hsa049661.28248745
45Proteoglycans in cancer_Homo sapiens_hsa052051.27696932
46MicroRNAs in cancer_Homo sapiens_hsa052061.23875877
47Serotonergic synapse_Homo sapiens_hsa047261.18415396
48Endometrial cancer_Homo sapiens_hsa052131.17985686
49Chronic myeloid leukemia_Homo sapiens_hsa052201.17504817
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16824632
51Bladder cancer_Homo sapiens_hsa052191.15527806
52Fanconi anemia pathway_Homo sapiens_hsa034601.15427018
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14880087
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.14018353
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13323014
56Salivary secretion_Homo sapiens_hsa049701.12800385
57Olfactory transduction_Homo sapiens_hsa047401.12748776
58Oxytocin signaling pathway_Homo sapiens_hsa049211.11635677
59Renin secretion_Homo sapiens_hsa049241.08673389
60Basal transcription factors_Homo sapiens_hsa030221.08216321
61Colorectal cancer_Homo sapiens_hsa052101.07482254
62Estrogen signaling pathway_Homo sapiens_hsa049151.06753574
63Vibrio cholerae infection_Homo sapiens_hsa051101.05206465
64Linoleic acid metabolism_Homo sapiens_hsa005911.03929289
65Oocyte meiosis_Homo sapiens_hsa041141.03378854
66Melanoma_Homo sapiens_hsa052181.02897721
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02571248
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99039123
69Dorso-ventral axis formation_Homo sapiens_hsa043200.97960781
70Propanoate metabolism_Homo sapiens_hsa006400.97310502
71Insulin secretion_Homo sapiens_hsa049110.97150375
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96755399
73Protein digestion and absorption_Homo sapiens_hsa049740.96113855
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94825737
75Butanoate metabolism_Homo sapiens_hsa006500.94511609
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93259416
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92638909
78Retinol metabolism_Homo sapiens_hsa008300.91638241
79Tight junction_Homo sapiens_hsa045300.88953614
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86400117
81Small cell lung cancer_Homo sapiens_hsa052220.86261150
82Ether lipid metabolism_Homo sapiens_hsa005650.86186081
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.84687750
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84683421
85Cardiac muscle contraction_Homo sapiens_hsa042600.84238475
86Rap1 signaling pathway_Homo sapiens_hsa040150.83689408
87Ras signaling pathway_Homo sapiens_hsa040140.83672103
88Gastric acid secretion_Homo sapiens_hsa049710.83671146
89TGF-beta signaling pathway_Homo sapiens_hsa043500.83233434
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82905623
91Viral myocarditis_Homo sapiens_hsa054160.82863348
92Pathways in cancer_Homo sapiens_hsa052000.82365513
93GnRH signaling pathway_Homo sapiens_hsa049120.82046147
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.81702224
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81307378
96Caffeine metabolism_Homo sapiens_hsa002320.80525289
97Parkinsons disease_Homo sapiens_hsa050120.78654586
98Calcium signaling pathway_Homo sapiens_hsa040200.78112358
99Non-small cell lung cancer_Homo sapiens_hsa052230.78099045
100Pancreatic cancer_Homo sapiens_hsa052120.74431982
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74406856
102Taste transduction_Homo sapiens_hsa047420.73245743
103Alcoholism_Homo sapiens_hsa050340.71988083
104cAMP signaling pathway_Homo sapiens_hsa040240.70776364
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69249651
106Selenocompound metabolism_Homo sapiens_hsa004500.68107448
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67309724
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66517460
109Thyroid hormone synthesis_Homo sapiens_hsa049180.66308388
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65872553
111MAPK signaling pathway_Homo sapiens_hsa040100.65676310
112Tryptophan metabolism_Homo sapiens_hsa003800.65476748
113Circadian rhythm_Homo sapiens_hsa047100.65068177
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.65007737
115Alzheimers disease_Homo sapiens_hsa050100.64034315
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63423800
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63255264
118Prostate cancer_Homo sapiens_hsa052150.62269325
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.62204184
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61873539
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58824275
122Notch signaling pathway_Homo sapiens_hsa043300.58801666
123Chemical carcinogenesis_Homo sapiens_hsa052040.57298775
124Amoebiasis_Homo sapiens_hsa051460.56608676
125N-Glycan biosynthesis_Homo sapiens_hsa005100.56063179
126Huntingtons disease_Homo sapiens_hsa050160.55921086
127Steroid biosynthesis_Homo sapiens_hsa001000.54456666
128Oxidative phosphorylation_Homo sapiens_hsa001900.54297394
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53926311
130Shigellosis_Homo sapiens_hsa051310.53385988
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53218501
132RNA degradation_Homo sapiens_hsa030180.52843282
133Phagosome_Homo sapiens_hsa041450.50219393
134Choline metabolism in cancer_Homo sapiens_hsa052310.49007649
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48614833
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47837558
137Glycerolipid metabolism_Homo sapiens_hsa005610.45671327
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44649969
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.42949812
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42603832
141Sulfur relay system_Homo sapiens_hsa041220.41920321
142ABC transporters_Homo sapiens_hsa020100.41036387

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