CDH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.59060302
2vocalization behavior (GO:0071625)5.57383167
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34495036
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30794639
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12521144
6synaptic vesicle exocytosis (GO:0016079)5.08168718
7neuronal action potential propagation (GO:0019227)5.01823723
8neuron cell-cell adhesion (GO:0007158)4.97009283
9locomotory exploration behavior (GO:0035641)4.88209563
10regulation of glutamate receptor signaling pathway (GO:1900449)4.87972128
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.79985318
12regulation of synaptic vesicle exocytosis (GO:2000300)4.71538913
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71009466
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69886213
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.51357808
16neurotransmitter-gated ion channel clustering (GO:0072578)4.48527630
17neurotransmitter secretion (GO:0007269)4.47924820
18glutamate receptor signaling pathway (GO:0007215)4.47608362
19glutamate secretion (GO:0014047)4.45992356
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.45756022
21synaptic transmission, glutamatergic (GO:0035249)4.44254645
22neuron-neuron synaptic transmission (GO:0007270)4.43443597
23synaptic vesicle maturation (GO:0016188)4.35113487
24behavioral response to ethanol (GO:0048149)4.27370050
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.26742950
26opioid receptor signaling pathway (GO:0038003)4.26649928
27protein localization to synapse (GO:0035418)4.24420312
28gamma-aminobutyric acid transport (GO:0015812)4.19417673
29positive regulation of action potential (GO:0045760)4.17707844
30presynaptic membrane assembly (GO:0097105)4.17258353
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12298012
32regulation of synaptic vesicle transport (GO:1902803)4.09363269
33neuronal action potential (GO:0019228)3.97135390
34presynaptic membrane organization (GO:0097090)3.95675712
35postsynaptic membrane organization (GO:0001941)3.94498757
36cerebellar Purkinje cell differentiation (GO:0021702)3.94092963
37pyrimidine nucleobase catabolic process (GO:0006208)3.93516463
38negative regulation of cytosolic calcium ion concentration (GO:0051481)3.90820848
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87536150
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85034613
41cerebellar granule cell differentiation (GO:0021707)3.81721439
42response to pheromone (GO:0019236)3.80830339
43long-term memory (GO:0007616)3.78150977
44regulation of action potential (GO:0098900)3.77745875
45indolalkylamine metabolic process (GO:0006586)3.70180004
46exploration behavior (GO:0035640)3.69851327
47startle response (GO:0001964)3.68687960
48transmission of nerve impulse (GO:0019226)3.68668471
49neurotransmitter transport (GO:0006836)3.66844246
50piRNA metabolic process (GO:0034587)3.63348388
51indole-containing compound catabolic process (GO:0042436)3.61976425
52indolalkylamine catabolic process (GO:0046218)3.61976425
53tryptophan catabolic process (GO:0006569)3.61976425
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61414001
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61361590
56positive regulation of synapse maturation (GO:0090129)3.58918658
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.58105712
58neuromuscular process controlling posture (GO:0050884)3.56180066
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.55850616
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54631682
61positive regulation of membrane potential (GO:0045838)3.54129825
62regulation of postsynaptic membrane potential (GO:0060078)3.51043056
63long-term synaptic potentiation (GO:0060291)3.49908711
64regulation of collateral sprouting (GO:0048670)3.49356540
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49264455
66protein polyglutamylation (GO:0018095)3.47865806
67regulation of neuronal synaptic plasticity (GO:0048168)3.47652295
68response to histamine (GO:0034776)3.47117908
69kynurenine metabolic process (GO:0070189)3.46713946
70neuron recognition (GO:0008038)3.45779082
71fucose catabolic process (GO:0019317)3.40991295
72L-fucose metabolic process (GO:0042354)3.40991295
73L-fucose catabolic process (GO:0042355)3.40991295
74auditory behavior (GO:0031223)3.40233416
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39751909
76regulation of neurotransmitter levels (GO:0001505)3.36497249
77regulation of neurotransmitter secretion (GO:0046928)3.33869913
78detection of light stimulus involved in visual perception (GO:0050908)3.33306595
79detection of light stimulus involved in sensory perception (GO:0050962)3.33306595
80nucleobase catabolic process (GO:0046113)3.32005962
81mechanosensory behavior (GO:0007638)3.31867866
82membrane depolarization during action potential (GO:0086010)3.30827766
83detection of calcium ion (GO:0005513)3.29862790
84regulation of synapse maturation (GO:0090128)3.28451294
85layer formation in cerebral cortex (GO:0021819)3.27803706
86response to auditory stimulus (GO:0010996)3.27299262
87membrane hyperpolarization (GO:0060081)3.26028076
88dendritic spine morphogenesis (GO:0060997)3.23339037
89proline transport (GO:0015824)3.22971506
90regulation of synapse structural plasticity (GO:0051823)3.22397214
91positive regulation of neurotransmitter transport (GO:0051590)3.22165948
92regulation of synaptic transmission, GABAergic (GO:0032228)3.21548211
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21434790
94indole-containing compound metabolic process (GO:0042430)3.20784155
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19193914
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19192505
97membrane depolarization (GO:0051899)3.19073912
98reflex (GO:0060004)3.18997118
99positive regulation of synapse assembly (GO:0051965)3.17262759
100regulation of neurotransmitter transport (GO:0051588)3.17187172
101regulation of acrosome reaction (GO:0060046)3.16648026
102synapse assembly (GO:0007416)3.16502375
103regulation of synaptic plasticity (GO:0048167)3.15773520
104adult walking behavior (GO:0007628)3.11760684
105synaptic transmission (GO:0007268)3.11124149
106regulation of vesicle fusion (GO:0031338)3.08714307
107striatum development (GO:0021756)3.07209779
108cellular potassium ion homeostasis (GO:0030007)3.07185783
109learning (GO:0007612)3.05612685
110synaptic vesicle endocytosis (GO:0048488)3.05544044
111positive regulation of neurotransmitter secretion (GO:0001956)3.02924981
112water-soluble vitamin biosynthetic process (GO:0042364)3.02559812
113tryptophan metabolic process (GO:0006568)3.01700359
114regulation of cilium movement (GO:0003352)3.00895018
115somite development (GO:0061053)2.99604201
116cell differentiation in hindbrain (GO:0021533)2.98925504
117hindbrain development (GO:0030902)2.98740972
118serotonin metabolic process (GO:0042428)2.97842349
119activation of protein kinase A activity (GO:0034199)2.97756219
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97592295
121sulfation (GO:0051923)2.97337640
122negative regulation of dendrite morphogenesis (GO:0050774)2.96536005
123positive regulation of synaptic transmission (GO:0050806)2.95621461
124regulation of respiratory system process (GO:0044065)2.95294653
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94160897
126axonal fasciculation (GO:0007413)2.94115368
127prepulse inhibition (GO:0060134)2.93696909
128cochlea development (GO:0090102)2.92195947
129glycine transport (GO:0015816)2.91152518
130neuronal ion channel clustering (GO:0045161)2.90223011
131central nervous system projection neuron axonogenesis (GO:0021952)2.90046008
132neural tube formation (GO:0001841)2.89402671
133regulation of synaptic transmission (GO:0050804)2.88721619
134long term synaptic depression (GO:0060292)2.87808091
135limb bud formation (GO:0060174)2.87180004
136dopamine transport (GO:0015872)2.87038889
137protein-cofactor linkage (GO:0018065)2.85354901
138kidney morphogenesis (GO:0060993)2.85015126
139regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84987670
140primary amino compound metabolic process (GO:1901160)2.81943773
141regulation of voltage-gated calcium channel activity (GO:1901385)2.81702234
142neuromuscular process (GO:0050905)2.81465697
143negative regulation of astrocyte differentiation (GO:0048712)2.78671854
144tachykinin receptor signaling pathway (GO:0007217)2.76836084
145nonmotile primary cilium assembly (GO:0035058)2.76142133
146retinal ganglion cell axon guidance (GO:0031290)2.75038919
147cAMP catabolic process (GO:0006198)2.73991822
148action potential (GO:0001508)2.73408424
149epithelial cilium movement (GO:0003351)2.72406227
150spinal cord motor neuron differentiation (GO:0021522)2.70798969
151rhodopsin mediated signaling pathway (GO:0016056)2.70217835
152retinal cone cell development (GO:0046549)2.69401953
153cell migration in hindbrain (GO:0021535)2.68988302
154negative regulation of telomere maintenance (GO:0032205)2.67131930
155central nervous system neuron axonogenesis (GO:0021955)2.66574912
156positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64700048
157cornea development in camera-type eye (GO:0061303)2.64444650
158cellular ketone body metabolic process (GO:0046950)2.62449309
159DNA deamination (GO:0045006)2.61629288
160adult feeding behavior (GO:0008343)2.61619275
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.60272340
162synaptic transmission, cholinergic (GO:0007271)2.59591480
163cilium morphogenesis (GO:0060271)2.58333477
164negative regulation of dendrite development (GO:2000171)2.57477311
165inner ear receptor stereocilium organization (GO:0060122)2.57258579
166mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56130434
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.56130434
168NADH dehydrogenase complex assembly (GO:0010257)2.56130434
169DNA methylation involved in gamete generation (GO:0043046)2.52039285
170protein localization to cilium (GO:0061512)2.51675283
171axoneme assembly (GO:0035082)2.51669901
172regulation of timing of cell differentiation (GO:0048505)2.50351674
173protein K11-linked deubiquitination (GO:0035871)2.48361086
174photoreceptor cell development (GO:0042461)2.46836296
175regulation of telomere maintenance (GO:0032204)2.46605091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74595804
2GBX2_23144817_ChIP-Seq_PC3_Human4.39003583
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03844112
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94254337
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91619891
6REST_21632747_ChIP-Seq_MESCs_Mouse2.57502584
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48879409
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48682293
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.47602325
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47229290
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47229290
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39452379
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37032525
14TAF15_26573619_Chip-Seq_HEK293_Human2.35665749
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.28495725
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26799466
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26451877
18DROSHA_22980978_ChIP-Seq_HELA_Human2.26365987
19* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14763066
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09647509
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08146639
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07564422
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06186490
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03618216
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00869680
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.00787977
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.98060927
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97237119
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94500584
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.94043724
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93893996
32EWS_26573619_Chip-Seq_HEK293_Human1.93236584
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90137836
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88341256
35SMAD4_21799915_ChIP-Seq_A2780_Human1.87889610
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87800307
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85217704
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.80237050
39AR_21572438_ChIP-Seq_LNCaP_Human1.78830384
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76649960
41P300_19829295_ChIP-Seq_ESCs_Human1.73584038
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70455969
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66560822
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63191435
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.58871727
46IGF1R_20145208_ChIP-Seq_DFB_Human1.56620398
47BCAT_22108803_ChIP-Seq_LS180_Human1.54530053
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53789810
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52883379
50CBP_20019798_ChIP-Seq_JUKART_Human1.52883379
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.51365371
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.49978985
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.48000540
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43095604
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40179529
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39526619
57STAT3_23295773_ChIP-Seq_U87_Human1.39376236
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38913739
59* AR_25329375_ChIP-Seq_VCAP_Human1.38835099
60RNF2_27304074_Chip-Seq_NSC_Mouse1.38762222
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38125335
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37783256
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36147659
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34524334
65FUS_26573619_Chip-Seq_HEK293_Human1.30123677
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28543554
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28238111
68* TCF4_23295773_ChIP-Seq_U87_Human1.28135066
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27897561
70ZNF274_21170338_ChIP-Seq_K562_Hela1.27434185
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25518377
72TP53_22573176_ChIP-Seq_HFKS_Human1.24171829
73* NANOG_18555785_Chip-Seq_ESCs_Mouse1.23693051
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23207231
75* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23042745
76* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22848971
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21526705
78TCF4_22108803_ChIP-Seq_LS180_Human1.21395839
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21123253
80NANOG_19829295_ChIP-Seq_ESCs_Human1.20510469
81SOX2_19829295_ChIP-Seq_ESCs_Human1.20510469
82ER_23166858_ChIP-Seq_MCF-7_Human1.20232605
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19704671
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19125635
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17995756
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.17615288
87* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17158074
88AR_19668381_ChIP-Seq_PC3_Human1.17103095
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.15898478
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.14361684
91* NFE2_27457419_Chip-Seq_LIVER_Mouse1.12331563
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12217497
93* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11837619
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11406213
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10865781
96* EZH2_27294783_Chip-Seq_NPCs_Mouse1.10779725
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.10596163
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10140461
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09377290
100IRF1_19129219_ChIP-ChIP_H3396_Human1.09192117
101* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08723977
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08524986
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08524986
104VDR_22108803_ChIP-Seq_LS180_Human1.07193228
105AHR_22903824_ChIP-Seq_MCF-7_Human1.06684738
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06320675
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.05461189
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05287626
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04979836
110* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04686679
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04274839
112* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04087288
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.03546369
114JUN_21703547_ChIP-Seq_K562_Human1.03521010
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03067416
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02999419
117MYC_18940864_ChIP-ChIP_HL60_Human1.02983177
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01826499
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00426147
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00259826
121* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00005227
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99814698
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99685655
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.99685655
125NCOR_22424771_ChIP-Seq_293T_Human0.99384529
126* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99040916
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98147090
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97985587
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.97469328
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95165857
131* KDM2B_26808549_Chip-Seq_REH_Human0.93947010
132* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93360674
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93252791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10370609
2MP0003880_abnormal_central_pattern4.76428321
3MP0003635_abnormal_synaptic_transmissio3.90031288
4MP0009046_muscle_twitch3.85204543
5MP0009745_abnormal_behavioral_response3.45682058
6MP0004270_analgesia3.21223992
7MP0002064_seizures3.18894613
8MP0002063_abnormal_learning/memory/cond3.09394705
9MP0001968_abnormal_touch/_nociception3.04860819
10MP0002572_abnormal_emotion/affect_behav2.87088749
11MP0002272_abnormal_nervous_system2.81492011
12MP0001486_abnormal_startle_reflex2.78660058
13MP0005423_abnormal_somatic_nervous2.65909368
14MP0002734_abnormal_mechanical_nocicepti2.62771138
15MP0002736_abnormal_nociception_after2.58364982
16MP0008877_abnormal_DNA_methylation2.49330920
17MP0002822_catalepsy2.45445123
18MP0001501_abnormal_sleep_pattern2.40212061
19MP0001440_abnormal_grooming_behavior2.26988109
20MP0002067_abnormal_sensory_capabilities2.22906843
21MP0002735_abnormal_chemical_nociception2.21180890
22MP0005646_abnormal_pituitary_gland2.11514745
23MP0006276_abnormal_autonomic_nervous2.10204598
24MP0003787_abnormal_imprinting2.02192167
25MP0008569_lethality_at_weaning2.02135660
26MP0001188_hyperpigmentation1.96585303
27MP0002184_abnormal_innervation1.94365978
28MP0001970_abnormal_pain_threshold1.92480841
29MP0002733_abnormal_thermal_nociception1.92131880
30MP0002557_abnormal_social/conspecific_i1.89894854
31MP0009780_abnormal_chondrocyte_physiolo1.87460093
32MP0003195_calcinosis1.87284746
33MP0003122_maternal_imprinting1.81740931
34MP0004924_abnormal_behavior1.81148118
35MP0005386_behavior/neurological_phenoty1.81148118
36MP0004142_abnormal_muscle_tone1.80154259
37MP0001984_abnormal_olfaction1.77372900
38MP0003283_abnormal_digestive_organ1.74977625
39MP0001529_abnormal_vocalization1.74045592
40MP0005645_abnormal_hypothalamus_physiol1.71417783
41MP0004133_heterotaxia1.68535772
42MP0000778_abnormal_nervous_system1.65596513
43MP0003879_abnormal_hair_cell1.65182914
44MP0002909_abnormal_adrenal_gland1.57437169
45MP0003136_yellow_coat_color1.42291260
46MP0004811_abnormal_neuron_physiology1.42171579
47MP0002066_abnormal_motor_capabilities/c1.40190732
48MP0000372_irregular_coat_pigmentation1.39254426
49MP0000955_abnormal_spinal_cord1.37891165
50MP0004742_abnormal_vestibular_system1.34477843
51MP0001905_abnormal_dopamine_level1.33559267
52MP0002653_abnormal_ependyma_morphology1.32885122
53MP0001502_abnormal_circadian_rhythm1.32503679
54MP0010386_abnormal_urinary_bladder1.30153702
55MP0002882_abnormal_neuron_morphology1.29574434
56MP0002234_abnormal_pharynx_morphology1.26341523
57MP0002938_white_spotting1.23256305
58MP0002751_abnormal_autonomic_nervous1.22014077
59MP0004885_abnormal_endolymph1.21114717
60MP0004145_abnormal_muscle_electrophysio1.19870583
61MP0002928_abnormal_bile_duct1.19055505
62MP0003633_abnormal_nervous_system1.17809144
63MP0000569_abnormal_digit_pigmentation1.17633088
64MP0002876_abnormal_thyroid_physiology1.16553744
65MP0005367_renal/urinary_system_phenotyp1.12487906
66MP0000516_abnormal_urinary_system1.12487906
67MP0005551_abnormal_eye_electrophysiolog1.10957970
68MP0000013_abnormal_adipose_tissue1.10922975
69MP0004147_increased_porphyrin_level1.08545009
70MP0003119_abnormal_digestive_system1.06959800
71MP0005195_abnormal_posterior_eye1.05734487
72MP0002638_abnormal_pupillary_reflex1.03607999
73MP0005084_abnormal_gallbladder_morpholo1.03447035
74MP0003631_nervous_system_phenotype1.02112862
75MP0008875_abnormal_xenobiotic_pharmacok1.01755771
76MP0001963_abnormal_hearing_physiology1.00806425
77MP0008872_abnormal_physiological_respon0.97511216
78MP0002152_abnormal_brain_morphology0.97495786
79MP0002837_dystrophic_cardiac_calcinosis0.97184573
80MP0000427_abnormal_hair_cycle0.97000959
81MP0004043_abnormal_pH_regulation0.96112497
82MP0005174_abnormal_tail_pigmentation0.96016810
83MP0002229_neurodegeneration0.95282707
84MP0003329_amyloid_beta_deposits0.94661627
85MP0005409_darkened_coat_color0.94569870
86MP0003718_maternal_effect0.93921273
87MP0003646_muscle_fatigue0.93879102
88MP0002095_abnormal_skin_pigmentation0.92913341
89MP0001986_abnormal_taste_sensitivity0.92249532
90MP0002069_abnormal_eating/drinking_beha0.91372147
91MP0000049_abnormal_middle_ear0.91332377
92MP0005187_abnormal_penis_morphology0.90263342
93MP0000631_abnormal_neuroendocrine_gland0.89910892
94MP0001177_atelectasis0.88381960
95MP0003011_delayed_dark_adaptation0.87634951
96MP0004085_abnormal_heartbeat0.87541524
97MP0004858_abnormal_nervous_system0.87343088
98MP0000538_abnormal_urinary_bladder0.85610177
99MP0002160_abnormal_reproductive_system0.82985013
100MP0002277_abnormal_respiratory_mucosa0.82769625
101MP0003121_genomic_imprinting0.82447920
102MP0004215_abnormal_myocardial_fiber0.80261043
103MP0003698_abnormal_male_reproductive0.79883115
104MP0005389_reproductive_system_phenotype0.78864671
105MP0001485_abnormal_pinna_reflex0.78711057
106MP0000230_abnormal_systemic_arterial0.77830534
107MP0003632_abnormal_nervous_system0.77517476
108MP0000751_myopathy0.77321447
109MP0001664_abnormal_digestion0.77319028
110MP0005535_abnormal_body_temperature0.76755016
111MP0002752_abnormal_somatic_nervous0.76504646
112MP0003937_abnormal_limbs/digits/tail_de0.75336599
113MP0008874_decreased_physiological_sensi0.75024294
114MP0005171_absent_coat_pigmentation0.74912326
115MP0006292_abnormal_olfactory_placode0.74340780
116MP0003938_abnormal_ear_development0.73707378
117MP0005394_taste/olfaction_phenotype0.72360722
118MP0005499_abnormal_olfactory_system0.72360722
119MP0005379_endocrine/exocrine_gland_phen0.72244964
120MP0006072_abnormal_retinal_apoptosis0.70110949
121MP0000026_abnormal_inner_ear0.68121636
122MP0004484_altered_response_of0.66664576
123MP0003634_abnormal_glial_cell0.64636256
124MP0003137_abnormal_impulse_conducting0.64427754
125MP0003690_abnormal_glial_cell0.62405439
126MP0002102_abnormal_ear_morphology0.60906993
127MP0003183_abnormal_peptide_metabolism0.60326203
128MP0001943_abnormal_respiration0.58837000
129MP0005253_abnormal_eye_physiology0.57617606
130MP0000920_abnormal_myelination0.56082938
131MP0002082_postnatal_lethality0.56057795
132MP0010770_preweaning_lethality0.56057795
133MP0002090_abnormal_vision0.54462573
134MP0010769_abnormal_survival0.53888703

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.59465117
2Atonic seizures (HP:0010819)6.07735432
3Febrile seizures (HP:0002373)6.07110219
4Focal seizures (HP:0007359)5.86127868
5Epileptic encephalopathy (HP:0200134)5.52678427
6Myokymia (HP:0002411)5.43133898
7Progressive cerebellar ataxia (HP:0002073)4.83189971
8Absence seizures (HP:0002121)4.57444198
9Visual hallucinations (HP:0002367)4.35789217
10Pancreatic cysts (HP:0001737)4.31739550
11Dialeptic seizures (HP:0011146)4.16727347
12Hyperventilation (HP:0002883)4.00358889
13Generalized tonic-clonic seizures (HP:0002069)4.00344260
14Pancreatic fibrosis (HP:0100732)3.93626199
15True hermaphroditism (HP:0010459)3.90297632
16Gaze-evoked nystagmus (HP:0000640)3.83417629
17Broad-based gait (HP:0002136)3.76169345
18Molar tooth sign on MRI (HP:0002419)3.74291349
19Abnormality of midbrain morphology (HP:0002418)3.74291349
20Action tremor (HP:0002345)3.61772883
21Nephronophthisis (HP:0000090)3.53470758
22Congenital stationary night blindness (HP:0007642)3.52851976
23Type II lissencephaly (HP:0007260)3.39441779
24Dysdiadochokinesis (HP:0002075)3.23175372
25Chronic hepatic failure (HP:0100626)3.14221222
26Truncal ataxia (HP:0002078)3.09081444
27Abnormality of binocular vision (HP:0011514)3.01118805
28Diplopia (HP:0000651)3.01118805
29Abnormal eating behavior (HP:0100738)3.00639155
30Abnormality of the renal medulla (HP:0100957)2.99630768
31Poor eye contact (HP:0000817)2.96163301
32Limb dystonia (HP:0002451)2.93462833
33Hemiparesis (HP:0001269)2.90734927
34Thyroid-stimulating hormone excess (HP:0002925)2.89929006
35Cystic liver disease (HP:0006706)2.81645625
36Anxiety (HP:0000739)2.80638194
37Scanning speech (HP:0002168)2.80159457
38Polyphagia (HP:0002591)2.76888623
39Epileptiform EEG discharges (HP:0011182)2.74035935
40Pendular nystagmus (HP:0012043)2.73970577
41Gait imbalance (HP:0002141)2.73057506
42Impaired social interactions (HP:0000735)2.69669007
43Abnormal social behavior (HP:0012433)2.69669007
44Abnormal hair whorl (HP:0010721)2.69295988
45Dysmetria (HP:0001310)2.67635178
46Impaired smooth pursuit (HP:0007772)2.66925488
47Status epilepticus (HP:0002133)2.66900341
48Pheochromocytoma (HP:0002666)2.65784184
49Abolished electroretinogram (ERG) (HP:0000550)2.63874415
50Depression (HP:0000716)2.63173309
51Abnormality of the renal cortex (HP:0011035)2.62766939
52Genetic anticipation (HP:0003743)2.59316214
53Attenuation of retinal blood vessels (HP:0007843)2.57479180
54Fetal akinesia sequence (HP:0001989)2.57101717
55Impaired vibration sensation in the lower limbs (HP:0002166)2.56979778
56Excessive salivation (HP:0003781)2.56927082
57Drooling (HP:0002307)2.56927082
58Sclerocornea (HP:0000647)2.56781591
59EEG with generalized epileptiform discharges (HP:0011198)2.56113809
60Lissencephaly (HP:0001339)2.55705779
61Amblyopia (HP:0000646)2.51262733
62Progressive inability to walk (HP:0002505)2.50546090
63Optic nerve hypoplasia (HP:0000609)2.44182010
64Agitation (HP:0000713)2.43641753
65Medial flaring of the eyebrow (HP:0010747)2.43336967
66Congenital primary aphakia (HP:0007707)2.41994561
67Hypsarrhythmia (HP:0002521)2.41291172
68Absent speech (HP:0001344)2.39878811
69Neuroendocrine neoplasm (HP:0100634)2.39405526
70Increased corneal curvature (HP:0100692)2.37856421
71Keratoconus (HP:0000563)2.37856421
72Hemiplegia (HP:0002301)2.37819381
73Abnormality of ocular smooth pursuit (HP:0000617)2.36425386
74Failure to thrive in infancy (HP:0001531)2.36367476
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34080337
76Urinary bladder sphincter dysfunction (HP:0002839)2.32687025
77Protruding tongue (HP:0010808)2.32106926
78Retinal dysplasia (HP:0007973)2.30363675
79Supranuclear gaze palsy (HP:0000605)2.30102795
80Tubular atrophy (HP:0000092)2.29690549
81Dysmetric saccades (HP:0000641)2.29066257
82Nephrogenic diabetes insipidus (HP:0009806)2.28584069
83Furrowed tongue (HP:0000221)2.28378458
84Decreased central vision (HP:0007663)2.22631137
85Anencephaly (HP:0002323)2.21380587
86Blue irides (HP:0000635)2.20732420
87Inability to walk (HP:0002540)2.18075690
88Abnormality of the labia minora (HP:0012880)2.15565992
89Stomach cancer (HP:0012126)2.15125286
90Intestinal atresia (HP:0011100)2.13548246
91Ankle clonus (HP:0011448)2.13036109
92Bradykinesia (HP:0002067)2.11879988
93Congenital sensorineural hearing impairment (HP:0008527)2.11316005
94Specific learning disability (HP:0001328)2.11294871
95Large for gestational age (HP:0001520)2.08986794
96Postural instability (HP:0002172)2.05763983
97Abnormal biliary tract physiology (HP:0012439)2.04445329
98Bile duct proliferation (HP:0001408)2.04445329
99Postural tremor (HP:0002174)2.04087727
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.04021776
101Esotropia (HP:0000565)2.03040582
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.02986412
103Bilateral microphthalmos (HP:0007633)2.02834550
104Spastic gait (HP:0002064)2.02674948
105Methylmalonic acidemia (HP:0002912)2.01133759
106Pachygyria (HP:0001302)1.99405334
107Male pseudohermaphroditism (HP:0000037)1.98229671
108Abnormal rod and cone electroretinograms (HP:0008323)1.98062267
109Abnormality of the corticospinal tract (HP:0002492)1.96763668
110Stereotypic behavior (HP:0000733)1.96651536
111Torticollis (HP:0000473)1.96508672
112Renal cortical cysts (HP:0000803)1.96209063
113Polydipsia (HP:0001959)1.95620330
114Abnormal drinking behavior (HP:0030082)1.95620330
115Cerebellar dysplasia (HP:0007033)1.95037885
116Genital tract atresia (HP:0001827)1.94835225
117Hypothermia (HP:0002045)1.93896849
118Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93049683
119Abnormality of alanine metabolism (HP:0010916)1.93049683
120Hyperalaninemia (HP:0003348)1.93049683
121Vaginal atresia (HP:0000148)1.92059824
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91981417
123Bony spicule pigmentary retinopathy (HP:0007737)1.91424106
124Concave nail (HP:0001598)1.91166807
125Acute necrotizing encephalopathy (HP:0006965)1.90876642
126Generalized myoclonic seizures (HP:0002123)1.90761885
127Postaxial foot polydactyly (HP:0001830)1.90344259
128Intention tremor (HP:0002080)1.90106110
129Gait ataxia (HP:0002066)1.90020338
130Absent/shortened dynein arms (HP:0200106)1.89988001
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.89988001
132Psychosis (HP:0000709)1.89773427
133Focal dystonia (HP:0004373)1.89234748
134Poor suck (HP:0002033)1.89176830
135Congenital, generalized hypertrichosis (HP:0004540)1.88867208
136Congenital hepatic fibrosis (HP:0002612)1.88845327
137Narrow nasal bridge (HP:0000446)1.88380285
138Impaired vibratory sensation (HP:0002495)1.85688360
139Mutism (HP:0002300)1.84920812
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84807788
141Abnormal ciliary motility (HP:0012262)1.83934552
142Sleep apnea (HP:0010535)1.83030898
143Decreased circulating renin level (HP:0003351)1.82972200
144Incomplete penetrance (HP:0003829)1.82704446
145Progressive macrocephaly (HP:0004481)1.82513184
146Hyperglycinemia (HP:0002154)1.81364676
147Methylmalonic aciduria (HP:0012120)1.80944282
148Abnormal mitochondria in muscle tissue (HP:0008316)1.80670466
149Abnormality of salivation (HP:0100755)1.78367718
150Abnormality of saccadic eye movements (HP:0000570)1.78315922
151Generalized hypopigmentation of hair (HP:0011358)1.78091419
152Urinary urgency (HP:0000012)1.76207668
153Poor coordination (HP:0002370)1.75703270
154Abnormal respiratory epithelium morphology (HP:0012253)1.75257742
155Abnormal respiratory motile cilium morphology (HP:0005938)1.75257742
156Resting tremor (HP:0002322)1.74757248
157Hyperthyroidism (HP:0000836)1.73775197
158Postaxial hand polydactyly (HP:0001162)1.72062703
159Chorioretinal atrophy (HP:0000533)1.69589717
160Neuronal loss in central nervous system (HP:0002529)1.68145590
161Anophthalmia (HP:0000528)1.67863111
162Aplasia/Hypoplasia of the patella (HP:0006498)1.67377980
163Supernumerary spleens (HP:0009799)1.67299152
164Cortical visual impairment (HP:0100704)1.67133752
165Bradycardia (HP:0001662)1.67124894
166Tented upper lip vermilion (HP:0010804)1.66984315
167Patellar aplasia (HP:0006443)1.66497428
168Mitochondrial inheritance (HP:0001427)1.65923028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.62414955
2CASK4.49521069
3NTRK34.26523253
4EPHA43.26587498
5MAP3K43.25590387
6MAP2K73.23350523
7MAP3K122.90634437
8MAP3K92.65376097
9MARK12.62289516
10TNIK2.61168096
11ZAK2.38793141
12MAP4K22.35379443
13GRK12.26438886
14NTRK22.17795316
15MINK12.09976367
16DAPK22.00446828
17TAOK32.00375566
18MAP2K41.96437944
19AKT31.80345112
20PRPF4B1.74938530
21CAMKK21.67662993
22MAPK131.66191298
23PLK21.64912144
24NUAK11.58293394
25WNK41.53599890
26DYRK21.49312985
27CDK191.45321281
28PNCK1.45217534
29DAPK11.44563314
30CDK51.44230292
31RIPK41.39694543
32SGK21.37666892
33PRKCG1.37532679
34CAMKK11.35924622
35SIK31.35675002
36FES1.29548744
37PAK61.27486436
38TLK11.27189149
39SGK2231.25864772
40SGK4941.25864772
41SIK21.25301908
42GRK51.19165386
43ACVR1B1.18730729
44FGFR21.16515063
45WNK31.15879734
46CAMK2A1.11757142
47INSRR1.11607742
48WNK11.11493708
49OXSR11.04908134
50NTRK11.03608831
51STK381.03273896
52ADRBK21.02295427
53KSR11.00479116
54STK390.98523735
55TRIM280.97321674
56CAMK2B0.96611964
57BMPR20.95676549
58STK38L0.95593965
59UHMK10.93993765
60PRKD30.93318716
61SGK30.91780232
62CSNK1G30.88043120
63PRKCE0.84961659
64PRKCH0.84746686
65CSNK1G10.84422684
66SGK10.83802266
67CCNB10.82249729
68CDK180.81173374
69TXK0.80862846
70CAMK1G0.78487161
71CDK150.76437477
72NEK60.76412742
73PHKG20.75169188
74PHKG10.75169188
75CDK140.72346150
76BCKDK0.71893170
77VRK10.70219915
78CSNK1A1L0.69159830
79MAP3K130.69150883
80CSNK1G20.68441162
81CAMK10.67951720
82STK110.67558235
83ERBB30.67181536
84TSSK60.66058856
85CAMK2D0.66027956
86PINK10.64575150
87MKNK20.64534932
88CDK11A0.64264350
89TGFBR10.64194363
90MARK20.63547577
91MKNK10.62303676
92BCR0.61740205
93CDK30.61366604
94ARAF0.59585592
95NME10.57648515
96CDC42BPA0.57477264
97DYRK1A0.56793584
98TNK20.55131312
99DYRK30.53215559
100KSR20.53051777
101CAMK2G0.53051193
102GRK70.52059727
103CSNK1D0.52003646
104TYRO30.50780656
105MAP3K20.50479424
106BRAF0.50160370
107TIE10.48432540
108RPS6KA30.47939403
109PRKACA0.46012901
110PIK3CA0.44794421
111PAK30.44624210
112RPS6KA50.44544748
113MAPK150.43077527
114PLK30.42674864
115PASK0.42668898
116PRKG10.42213770
117PRKCZ0.42124434
118PRKCB0.41659805
119BMPR1B0.39605399
120FYN0.39134720
121CAMK40.38668665
122PDK10.37881482
123PRKCQ0.37590673
124MAPKAPK50.37487531
125PRKCA0.36484261
126LMTK20.35361364
127IKBKB0.35114219
128MUSK0.34962663
129PDPK10.34682173
130PKN10.33801391
131CAMK1D0.33499068
132ADRBK10.33303656
133PRKAA10.32929564
134CSNK1A10.32025432
135PTK2B0.31870951
136EIF2AK30.31815958
137MAPK100.31587121
138ERBB20.31400818
139KIT0.31327405
140BRSK20.30669804
141TEC0.29968829
142PRKACB0.29958636

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.55463608
2Synaptic vesicle cycle_Homo sapiens_hsa047213.60237300
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.02084457
4GABAergic synapse_Homo sapiens_hsa047272.94617721
5Morphine addiction_Homo sapiens_hsa050322.76490271
6Circadian entrainment_Homo sapiens_hsa047132.67350531
7Glutamatergic synapse_Homo sapiens_hsa047242.65799962
8Long-term potentiation_Homo sapiens_hsa047202.51624040
9Olfactory transduction_Homo sapiens_hsa047402.47528270
10Amphetamine addiction_Homo sapiens_hsa050312.40232073
11Taste transduction_Homo sapiens_hsa047422.36664462
12Collecting duct acid secretion_Homo sapiens_hsa049662.34557772
13Linoleic acid metabolism_Homo sapiens_hsa005912.21909878
14Insulin secretion_Homo sapiens_hsa049112.17423415
15Dopaminergic synapse_Homo sapiens_hsa047282.14735028
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09389115
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08468695
18Salivary secretion_Homo sapiens_hsa049702.02960082
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02306517
20Selenocompound metabolism_Homo sapiens_hsa004502.00442024
21Serotonergic synapse_Homo sapiens_hsa047261.97335912
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93401198
23Long-term depression_Homo sapiens_hsa047301.91860575
24Tryptophan metabolism_Homo sapiens_hsa003801.81652704
25Cocaine addiction_Homo sapiens_hsa050301.77664175
26Cholinergic synapse_Homo sapiens_hsa047251.76154556
27Nitrogen metabolism_Homo sapiens_hsa009101.75964336
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.75685034
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67618377
30Calcium signaling pathway_Homo sapiens_hsa040201.64933255
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64850071
32Renin secretion_Homo sapiens_hsa049241.64555797
33Gastric acid secretion_Homo sapiens_hsa049711.63359586
34Ether lipid metabolism_Homo sapiens_hsa005651.58355330
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54111928
36Caffeine metabolism_Homo sapiens_hsa002321.45861207
37Oxytocin signaling pathway_Homo sapiens_hsa049211.45271397
38Vibrio cholerae infection_Homo sapiens_hsa051101.44310857
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37658699
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.34684742
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31602348
42Homologous recombination_Homo sapiens_hsa034401.29265793
43Oxidative phosphorylation_Homo sapiens_hsa001901.28476727
44Type II diabetes mellitus_Homo sapiens_hsa049301.20603695
45cAMP signaling pathway_Homo sapiens_hsa040241.18579162
46Propanoate metabolism_Homo sapiens_hsa006401.17885580
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17700768
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15953825
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15577588
50Chemical carcinogenesis_Homo sapiens_hsa052041.14343777
51Protein export_Homo sapiens_hsa030601.13659734
52Gap junction_Homo sapiens_hsa045401.13522467
53GnRH signaling pathway_Homo sapiens_hsa049121.13329436
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13062586
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12379182
56Fanconi anemia pathway_Homo sapiens_hsa034601.11646197
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11540042
58Cardiac muscle contraction_Homo sapiens_hsa042601.11268640
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.10993889
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10120243
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08134529
62Basal transcription factors_Homo sapiens_hsa030221.06442519
63Type I diabetes mellitus_Homo sapiens_hsa049401.02923489
64Phototransduction_Homo sapiens_hsa047440.99288930
65Retinol metabolism_Homo sapiens_hsa008300.98665689
66Alzheimers disease_Homo sapiens_hsa050100.98600530
67ABC transporters_Homo sapiens_hsa020100.97842217
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95734086
69Axon guidance_Homo sapiens_hsa043600.95485721
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95182661
71Estrogen signaling pathway_Homo sapiens_hsa049150.93869913
72Arachidonic acid metabolism_Homo sapiens_hsa005900.93638790
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92974544
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91513292
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.89916508
76Parkinsons disease_Homo sapiens_hsa050120.86887321
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.86423712
78RNA polymerase_Homo sapiens_hsa030200.85102859
79Pancreatic secretion_Homo sapiens_hsa049720.84612036
80Melanogenesis_Homo sapiens_hsa049160.83298638
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81870272
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78738745
83ErbB signaling pathway_Homo sapiens_hsa040120.76883485
84Asthma_Homo sapiens_hsa053100.76585809
85Peroxisome_Homo sapiens_hsa041460.76237634
86Rheumatoid arthritis_Homo sapiens_hsa053230.74285252
87RNA degradation_Homo sapiens_hsa030180.73679645
88Glycerolipid metabolism_Homo sapiens_hsa005610.68819632
89Thyroid hormone synthesis_Homo sapiens_hsa049180.66310045
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66062707
91Dilated cardiomyopathy_Homo sapiens_hsa054140.65401846
92MAPK signaling pathway_Homo sapiens_hsa040100.64657239
93Histidine metabolism_Homo sapiens_hsa003400.62910995
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62532416
95Huntingtons disease_Homo sapiens_hsa050160.61809154
96Glioma_Homo sapiens_hsa052140.58225556
97Circadian rhythm_Homo sapiens_hsa047100.57706441
98Inositol phosphate metabolism_Homo sapiens_hsa005620.56815236
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55768279
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.55702312
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54935481
102beta-Alanine metabolism_Homo sapiens_hsa004100.53693678
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53609470
104Basal cell carcinoma_Homo sapiens_hsa052170.52639097
105Oocyte meiosis_Homo sapiens_hsa041140.51787977
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51629532
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49826720
108Metabolic pathways_Homo sapiens_hsa011000.49127042
109Glucagon signaling pathway_Homo sapiens_hsa049220.48905570
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48510491
111Ovarian steroidogenesis_Homo sapiens_hsa049130.48504707
112One carbon pool by folate_Homo sapiens_hsa006700.48191971
113Ras signaling pathway_Homo sapiens_hsa040140.47732142
114Choline metabolism in cancer_Homo sapiens_hsa052310.46346696
115Purine metabolism_Homo sapiens_hsa002300.46141388
116Fatty acid biosynthesis_Homo sapiens_hsa000610.46016022
117Fat digestion and absorption_Homo sapiens_hsa049750.45467225
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44374490
119Dorso-ventral axis formation_Homo sapiens_hsa043200.43869955
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42195629
121Non-homologous end-joining_Homo sapiens_hsa034500.41770398
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41667495
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41602581
124Steroid biosynthesis_Homo sapiens_hsa001000.41328905
125Alcoholism_Homo sapiens_hsa050340.41141353
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40641251
127African trypanosomiasis_Homo sapiens_hsa051430.37979987
128Rap1 signaling pathway_Homo sapiens_hsa040150.37480575
129Wnt signaling pathway_Homo sapiens_hsa043100.37068928
130Phagosome_Homo sapiens_hsa041450.36634086
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35636115
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34373042
133Sulfur metabolism_Homo sapiens_hsa009200.33778566
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33360547
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32189064
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.31974012
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30622789
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.28760329
139Graft-versus-host disease_Homo sapiens_hsa053320.27787577
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26058265
141Starch and sucrose metabolism_Homo sapiens_hsa005000.24587461
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24586971
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23999827
144Butanoate metabolism_Homo sapiens_hsa006500.23835155
145Regulation of autophagy_Homo sapiens_hsa041400.23571833
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.23152673
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19947153
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19020023
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18368757
150Chemokine signaling pathway_Homo sapiens_hsa040620.17670868
151Hedgehog signaling pathway_Homo sapiens_hsa043400.16891565
152Melanoma_Homo sapiens_hsa052180.16331882

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